170
Views
10
CrossRef citations to date
0
Altmetric
Articles

Can numerical modeling help understand the fate of tau protein in the axon terminal?

&
Pages 115-125 | Received 20 Oct 2014, Accepted 29 Nov 2014, Published online: 07 Jan 2015

References

  • Beharry C, Cohen LS, Di J, Ibrahim K, Briffa-Mirabella S, Alonso Adel C. 2014. Tau-induced neurodegeneration: mechanisms and targets. Neurosci Bull. 30:346–358.
  • Black MM, Slaughter T, Moshiach S, Obrocka M, Fischer I. 1996. Tau is enriched on dynamic microtubules in the distal region of growing axons. J Neurosci. 16:3601–3619.
  • Conde C, Caceres A. 2009. Microtubule assembly, organization and dynamics in axons and dendrites. Nat Rev Neurosci. 10:319–332.
  • Cuchillo-Ibanez I, Seereeram A, Byers HL, Leung K, Ward MA, Anderton BH, Hanger DP. 2008. Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin. FASEB J. 22:3186–3195.
  • Gauthier-Kemper A, Weissmann C, Golovyashkina N, Seboe-Lemke Z, Drewes G, Gerke V, Heinisch JJ, Brandt R. 2011. The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner. J Cell Biol. 192:647–661.
  • Gendron TF, Petrucelli L. 2009. The role of tau in neurodegeneration. Mol Neurodegener. 4:13.
  • Hinrichs MH, Jalal A, Brenner B, Mandelkow E, Kumar S, Scholz T. 2012. Tau protein diffuses along the microtubule lattice. J Biol Chem. 287:38559–38568.
  • Ittner A, Ke YD, van Eersel J, Gladbach A, Goetz J, Ittner LM. 2011. Brief update on different roles of tau in neurodegeneration. IUBMB Life. 63:495–502.
  • Jung P, Brown A. 2009. Modeling the slowing of neurofilament transport along the mouse sciatic nerve. Phys Biol. 6:046002.
  • Kempf M, Clement A, Faissner A, Lee G, Brandt R. 1996. Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner. J Neurosci. 16:5583–5592.
  • Kierszenbaum A. 2000. The 26S proteasome: ubiquitin-mediated proteolysis in the tunnel. Mol Reprod Dev. 57:109–110.
  • Konzack S, Thies E, Marx A, Mandelkow E-M, Mandelkow E. 2007. Swimming against the tide: mobility of the microtubule-associated protein tau in neurons. J Neurosci. 27:9916–9927.
  • Kuznetsov IA, Kuznetsov AV. Forthcoming 2014a. A comparison between the diffusion-reaction and slow axonal transport models for predicting tau distribution along an axon. Math Med Biol. doi:10.1093/imammb/dqu003.
  • Kuznetsov IA, Kuznetsov AV. Forthcoming 2014b. A coupled model of fast axonal transport of organelles and slow axonal transport of tau protein. Comput Methods Biomech Biomed Eng. doi:10.1080/10255842.2014.920830.
  • Li X, Kumar Y, Zempel H, Mandelkow E-M, Biernat J, Mandelkow E. 2011. Novel diffusion barrier for axonal retention of tau in neurons and its failure in neurodegeneration. EMBO J. 30:4825–4837.
  • Li Y, Jung P, Brown A. 2012. Axonal transport of neurofilaments: A single population of intermittently moving polymers. J Neurosci. 32:746–758.
  • Luan K, Rosales JL, Lee K. 2013. Viewpoint: crosstalks between neurofibrillary tangles and amyloid plaque formation. Ageing Res Rev. 12:174–181.
  • Mandelkow E-M, Mandelkow E. 2012. Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med. 2:a006247.
  • Mandell J, Banker G. 1996. A spatial gradient of tau protein phosphorylation in nascent axons. J Neurosci. 16:5727–5740.
  • Mercken M, Fischer I, Kosik K, Nixon R. 1995. Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evidence for dynamic interactions of tau with microtubules in vivo. J Neurosci. 15:8259–8267.
  • Peter SJ, Mofrad MRK. 2012. Computational modeling of axonal microtubule bundles under tension. Biophys J. 102:749–757.
  • Pooler AM, Noble W, Hanger DP. 2014. A role for tau at the synapse in Alzheimer's disease pathogenesis. Neuropharmacology. 76:1–8.
  • Poppek D, Keck S, Ermak G, Jung T, Stolzing A, Ullrich O, Davies KJA, Grune T. 2006. Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. Biochem J. 400:511–520.
  • Rodriguez-Martin T, Cuchillo-Ibanez I, Noble W, Nyenya F, Anderton BH, Hanger DP. 2013. Tau phosphorylation affects its axonal transport and degradation. Neurobiol Aging. 34:2146–2157.
  • Samsonov A, Yu JZ, Rasenick M, Popov SV. 2004. Tau interaction with microtubuies in vivo. J Cell Sci. 117:6129–6141.
  • Satkauskas S, Bagnard D. 2007. Local protein synthesis in axonal growth cones what is next? Cell Adhes Migration. 1:179–184.
  • Scholz T, Mandelkow E. 2014. Transport and diffusion of tau protein in neurons. Cell Mol Life Sci. 71:3139–3150.
  • Sotelo-Silveira J, Calliari A, Kun A, Koenig E, Sotelo J. 2006. RNA trafficking in axons. Traffic. 7:508–515.
  • Tien N, Wu G, Hsu C, Chang C, Wagner OI. 2011. Tau/PTL-1 associates with kinesin-3 KIF1A/UNC-104 and affects the motor's motility characteristics in C. elegans neurons. Neurobiol Dis. 43:495–506.
  • Utton M, Connell J, Asuni A, van Slegtenhorst M, Hutton M, de Silva R, Lees A, Miller C, Anderton B. 2002. The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons. J Neurosci. 22:6394–6400.
  • Utton M, Noble W, Hill J, Anderton B, Hanger D. 2005. Molecular motors implicated in the axonal transport of tau and alpha-synuclein. J Cell Sci. 118:4645–4654.
  • Vila-Ortiz G, Santa-Coloma T, Carminatti H, Radrizzani M. 2001. The rate of tau synthesis is differentially regulated during postnatal development in mouse cerebellum. Cell Mol Neurobiol. 21:535–543.
  • Weissmann C, Reyher H, Gauthier A, Steinhoff H, Junge W, Brandt R. 2009. Microtubule binding and trapping at the tip of neurites regulate tau motion in living neurons. Traffic. 10:1655–1668.
  • White FM. 2011. Fluid mechanics. 7th ed. New York: McGraw-Hill.
  • Ye C, Li B, Sun W. 2010. Quasi-steady-state and steady-state models for heat and moisture transport in textile assemblies. Proc R Soc A Math Phys Eng Sci. 466:2875–2896.
  • Zheng J, Kelly T, Chang B, Ryazantsev S, Rajasekaran A, Martin K, Twiss J. 2001. A functional role for intra-axonal protein synthesis during axonal regeneration from adult sensory neurons. J Neurosci. 21:9291–9303.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.