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1. Fundamentals on Isotope Effects

Mechanism from Isotope Effects

Pages 3-17 | Received 07 Nov 1997, Accepted 03 Feb 1998, Published online: 24 Sep 2006

References

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  • Cleland , W. W. 1991 . “ Multiple isotope effects in enzyme‐catalyzed reactions ” . In Enzyme Mechanism from Isotope Effects , Edited by: Cook , P. F. 248 – 265 . Boca Raton : CRC Press .
  • Hermes , J. D. , Morrical , S. W. , O'Leary , M. H. and Cleland , W. W. 1984 . Variation of transition‐state structure as a function of the nucleotide in reactions catalyzed by dehydrogenases. 2. formate dehydrogenase . Biochemistry , 23 : 5479 – 5488 .
  • Hermes , J. D. , Roeske , C. A. , O'Leary , M. H. and Cleland , W. W. 1982 . Use of multiple isotope effects to determine enzyme mechanisms and intrinsic isotope effects. Malic enzyme and glucose 6‐phosphate dehydrogenase . Biochemistry , 21 : 5106 – 5114 .
  • Karsten , W. E. and Cook , P. F. 1994 . Stepwise versus concerted oxidative decarboxylation catalyzed by malic enzyme: A reinvestigation . Biochemistry , 33 : 2096 – 2103 .
  • Weiss , P. M. , Gavva , S. R. , Harris , B. G. , Urbauer , J. , Cleland , W. W. and Cook , P. F. 1991 . Multiple isotope effects with alternative dinucleotide substrates as a probe of the malic enzyme reaction . Biochemistry , 30 : 5755 – 5763 .
  • Edens , W. A. , Urbauer , J. and Cleland , W. W. 1997 . Determination of the chemical mechanism of malic enzyme by isotope effects . Biochemistry , 36 : 1141 – 1147 .
  • Cook , P. F. , ed. 1991 . Enzyme Mechanism from Isotope Effects , Boca Raton : CRC Press Inc. .

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