Review

References

• Allen, K.G. and Harris, M.A. (2001 ) “The role of n-3 fatty acids in gestation and parturition”, Experimental Biology and Medicine 226, 498–506.
   PubMed Web of Science ®Google Scholar
• Audi, L., Mantzoros, C.S., Vidal-Puig, A., Vargas, D., Gussinye, M. and Carrascosa, A. (1998 ) “Leptin in relation to resumption of menses in women with anorexia nervosa”, Molecular Psychiatry 3, 544–547.
   PubMed Web of Science ®Google Scholar
• Bakan, R., Birmingham, C.L., Aeberhardt, L. and Goldner, E.M. (1993 ) “Dietary zinc intake of vegetarian and nonvegetarian patients with anorexia nervosa”, International Journal of Eating Disorders 13, 229–233.
   PubMed Web of Science ®Google Scholar
• Barber, M.D., Ross, J.A., Preston, T., Shenkin, A. and Fearon, K.C. (1999) “Fish oil-enriched nutritional supplement attenuates progression of the acute-phase response in weight-losing patients with advanced pancreatic cancer”, Journal of Nutrition 129 , 1120–1125.
   PubMed Web of Science ®Google Scholar
• Birch, E.E., Hoffman, D.R., Castaneda, Y.S., Fawcett, S.L., Birch, D. G. and Uauy, R.D. (2002 ) “A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age”, American Journal of Clinical Nutrition 75, 570–580.
   PubMed Web of Science ®Google Scholar
• Birmingham, C.L., Goldner, E.M. and Bakan, R. (1994 ) “Controlled trial of zinc supplementation in anorexia nervosa”, International Journal of Eating Disorders 15, 251–255.
   PubMed Web of Science ®Google Scholar
• Bjerve, K.S. (1989 ) “n-3 fatty acid deficiency in man”, Journal of Internal Medicine 225 (Suppl.), 171–175.
   Google Scholar
• Bjerve, K.S., Thoresen, L., Mostad, I.L. and Alme, K. (1987 ) “Alpha- linolenic acid deficiency in man: effect of essential fatty acids on fatty acid composition”, Advances in Prostaglandin, Thromboxane, and Leukotriene Research 17B, 862–865.
   PubMedGoogle Scholar
• Bjerve, K.S., Thoresen, L. and Borsting, S. (1988 ) “Linseed and cod liver oil induce rapid growth in a 7-year-old girl with N-3- fatty acid deficiency”, Jpen: Journal of Parenteral and Enteral Nutrition 12, 521–525.
   PubMed Web of Science ®Google Scholar
• Bjerve, K.S., Fischer, S., Wammer, F. and Egeland, T. (1989 ) “alpha- Linolenic acid and long-chain omega-3 fatty acid supplementation in three patients with omega-3 fatty acid deficiency: effect on lymphocyte function, plasma and red cell lipids, and prostanoid formation”, American Journal of Clinical Nutrition 49, 290–300.
   PubMed Web of Science ®Google Scholar
• Boland, B., Beguin, C., Zech, F., Desager, J.P. and Lambert, M. (2001 ) “Serum beta-carotene in anorexia nervosa patients: a case-control study”, International Journal of Eating Disorders 30, 299–305.
   PubMed Web of Science ®Google Scholar
• Brinch, M., Isager, T. and Tolstrup, K. (1988 ) “Anorexia nervosa and motherhood: reproduction pattern and mothering behavior of 50 women”, Acta Psychiatrica Scandinavica 77, 611–617, [republished from Acta Psychiatr. Scand., 77(1), 98–104].
   PubMed Web of Science ®Google Scholar
• Bulik, C.M., Sullivan, P.F., Fear, J.L., Pickering, A., Dawn, A. and McCullin, M. (1999 ) “Fertility and reproduction in women with anorexia nervosa: a controlled study”, Journal of Clinical Psychiatry 60, 130–135.
   PubMed Web of Science ®Google Scholar
• Burdge, G.C. and Wootton, S.A. (2002 ) “Conversion of alpha- linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women”, British Journal of Nutrition 88, 411–420.
   PubMed Web of Science ®Google Scholar
• Buydens-Branch, Branchey, M., McMakin, D.L. and Hibbeln, J.R. (2003) “Polyunsaturated fatty acid status and aggression in cocaine addicts”, Drug and Alcohol Dependence, In Press, Corrected Proof.
   Web of Science ®Google Scholar
• Calder, P.C. (2001 ) “Polyunsaturated fatty acids, inflammation, and immunity”, Lipids 36, 1007–1024.
   PubMed Web of Science ®Google Scholar
• Calder, P.C. (2002 ) “Dietary modification of inflammation with lipids”, Proceedings of the Nutrition Society 61, 345–358.
   PubMed Web of Science ®Google Scholar
• Calder, P.C., Yaqoob, P., Thies, F., Wallace, F.A. and Miles, E.A. (2002 ) “Fatty acids and lymphocyte functions”, British Journal of Nutrition 87 (Suppl. 1), S31–S48.
   PubMed Web of Science ®Google Scholar
• Case, T., Lemieux, S., Kennedy, S.H. and Lewis, G.F. (1999 ) “Elevated plasma lipids in patients with binge eating disorders are found only in those who are anorexic”, International Journal of Eating Disorders 25, 187–193.
   PubMed Web of Science ®Google Scholar
• Casper, R.C. (1998 ) “Depression and eating disorders”, Depression and Anxiety 8 (Suppl. 1), 96–104.
   PubMedGoogle Scholar
• Cnattingius, S., Hultman, C.M., Dahl, M. and Sparen, P. (1999 ) “Very preterm birth, birth trauma, and the risk of anorexia nervosa among girls”, Archives of General Psychiatry 56, 634–638.
   PubMed Web of Science ®Google Scholar
• Conti, J., Abraham, S. and Taylor, A. (1998 ) “Eating behavior and pregnancy outcome”, Journal of Psychosomatic Research 44, 465–477.
   PubMed Web of Science ®Google Scholar
• Crow, S., Praus, B. and Thuras, P. (1999 ) “Mortality from eating disorders—a 5- to 10-year record linkage study”, International Journal of Eating Disorders 26, 97–101.
   PubMed Web of Science ®Google Scholar
• Cunnane, S.C. and Yang, J. (1995 ) “Zinc deficiency impairs whole- body accumulation of polyunsaturates and increases the utilization of [1–14C]linoleate for de novo lipid synthesis in pregnant rats”, Canadian Journal ofPhysiology and Pharmacology 73, 1246–1252.
   PubMed Web of Science ®Google Scholar
• Donohoe, T.P. (1984 ) “Stress-induced anorexia: implications for anorexia nervosa”, Life Sciences 34, 203–218.
   PubMed Web of Science ®Google Scholar
• Drewnowski, A., Pierce, B. and Halmi, K.A. (1988 ) “Fat aversion in eating disorders”, Appetite 10, 119–131.
   PubMed Web of Science ®Google Scholar
• Dubois, A., Gross, H.A., Ebert, M.H. and Castell, D.O. (1979 ) “Altered gastric emptying and secretion in primary anorexia nervosa”, Gastroenterology 77, 319–323.
   PubMed Web of Science ®Google Scholar
• Duman, R.S. (2002 ) “Genetics of childhood disorders: XXXIX. Stem cell research, part 3, Regulation of neurogenesis by stress and antidepressant treatment”, Journal of the American Academy of Child and Adolescent Psychiatry 41, 745–748.
   PubMedGoogle Scholar
• Durrington, P.N., Bhatnagar, D., Mackness, M.I., Morgan, J., Julier, K., Khan, M.A. and France, M. (2001 ) “An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglycer- idaemia”, Heart (British Cardiac Society) 85, 544–548.
   PubMed Web of Science ®Google Scholar
• Eder, K. and Kirchgessner, M. (1996 ) “Zinc deficiency and the desaturation of linoleic acid in rats force-fed fat-free diets”, Biological Trace Element Research 54, 173–183.
   PubMed Web of Science ®Google Scholar
• Fearon, K.C., von Meyenfeldt, M., Moses, A.G., van Geenen, R., Roy, A., Gouma, D., Giacosa, A., van Gossum, A. and Tisdale, M.J. (2001 ) “An energy and protein dense, high n-3 fatty acid oral supplement promotes weight gain in cancer cachexia”, European Journal of Cancer 37, 90.
   Google Scholar
• Fenton, W.S., Hibbeln, J. and Knable, M. (2000 ) “Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia”, Biological Psychiatry 47, 8–21.
   PubMed Web of Science ®Google Scholar
• Fenton, W.S., Dickerson, F., Boronow, J., Hibbeln, J.R. and Knable, M. (2001 ) “A placebo-controlled trial of omega-3 fatty acid (ethyl eicosapentaenoic acid) supplementation for residual symptoms and cognitive impairment in schizophrenia”, American Journal of Psychiatry 158, 2071–2074.
   PubMed Web of Science ®Google Scholar
• Fichter, M.M., Elton, M., Sourdi, L., Weyerer, S. and Koptagel-Ilal, G. (1988 ) “Anorexia nervosa in Greek and Turkish adolescents”, European Archives of Psychiatry and Neurological Sciences 237, 200–208.
   PubMedGoogle Scholar
• Foley, D.L., Thacker, L.R., Aggen, S.H., Neale, M.C. and Kendler, K.S. (2001 ) “Pregnancy and perinatal complications associated with risks for common psychiatric disorders in a population-based sample of female twins”, American Journal of Medical Genetics 105, 426–431.
   PubMed Web of Science ®Google Scholar
• Franko, D.L., Blais, M.A., Becker, A.E., Delinsky, S.S., Greenwood, D. N., Flores, A.T., Ekeblad, E.R., Eddy, K.T. and Herzog, D.B. (2001) “Pregnancy complications and neonatal outcomes in women with eating disorders”, American Journal of Psychiatry 158, 1461–1466.
   PubMed Web of Science ®Google Scholar
• Frederich, R., Hu, S., Raymond, N. and Pomeroy, C. (2002 ) “Leptin in anorexia nervosa and bulimia nervosa: importance of assay technique and method of interpretation”, Journal of Laboratory and Clinical Medicine 139, 72–79.
   PubMed Web of Science ®Google Scholar
• Geiser, F., Murtz, P., Lutterbey, G., Traber, F., Block, W., Imbierowicz, K., Schilling, G., Schild, H. and Liedtke, R. (2001 ) “Magnetic resonance spectroscopic and relaxometric determination of bone marrow changes in anorexia nervosa”, Psychosomatic Medicine 63, 631–637.
   PubMed Web of Science ®Google Scholar
• Gerster, H. (1998 ) “Can adults adequately convert alpha-linolenic acid (18:3n-3) to eicosapentaenoic acid (20:5n-3) and doc- osahexaenoic acid (22:6n–3)?”, International Journal for Vitamin and Nutrition Research 68, 159–173.
   PubMed Web of Science ®Google Scholar
• Grinspoon, S., Gulick, T., Askari, H., Landt, M., Lee, K., Anderson, E. , Ma, Z., Vignati, L., Bowsher, R., Herzog, D. and Klibanski, A. (1996) “Serum leptin levels in women with anorexia nervosa”, Journal of Clinical Endocrinology and Metabolism 81, 3861–3863.
   PubMed Web of Science ®Google Scholar
• Grinspoon, S., Thomas, E., Pitts, S., Gross, E., Mickley, D., Miller, K., Herzog, D. and Klibanski, A. (2000 ) “Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa”, Annals of Internal Medicine 133, 790–794.
   PubMed Web of Science ®Google Scholar
• Gruppo Italiano per lo Studio della Sopravvivenza nell ’Infarto miocardico(1999 ) “Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial”, Lancet 354, 447–455.
   Google Scholar
• Haluzik, M., Papezova, M., Nedvidkova, J. and Kabrt, J. (1999 ) “Serum leptin levels in patients with anorexia nervosa before and after partial refeeding, relationships to serum lipids and biochemical nutritional parameters”, Physiological Research 48, 197–202.
   PubMed Web of Science ®Google Scholar
• Hambidge, M. (2000 ) “Human zinc deficiency”, Journal of Nutrition 130, 1344S–1349S.
   PubMed Web of Science ®Google Scholar
• Harper, C.R. and Jacobson, T.A. (2001 ) “The fats of life: the role of omega-3 fatty acids in the prevention of coronary heart disease”, Archives of Internal Medicine 161, 2185–2192.
   PubMed Web of Science ®Google Scholar
• Hartman, D., Crisp, A., Rooney, B., Rackow, C., Atkinson, R. and Patel, S. (2000 ) “Bone density of women who have recovered from anorexia nervosa”, International Journal of Eating Disorders 28, 107–112.
   PubMed Web of Science ®Google Scholar
• Hergenroeder, A.C. (1995 ) “Bone mineralization, hypothalamic amenorrhea, and sex steroid therapy in female adolescents and young adults”, Journal of Pediatrics 126, 683–689.
   PubMed Web of Science ®Google Scholar
• Herzog, D.B., Nussbaum, K.M. and Marmor, A.K. (1996 ) “Comorbidity and outcome in eating disorders”, Psychiatric Clinics of North America 19, 843–859.
   PubMed Web of Science ®Google Scholar
• Herzog, D.B., Greenwood, D.N., Dorer, D.J., Flores, A.T., Ekeblad, E. R., Richards, A., Blais, M.A. and Keller, M.B. (2000 ) “Mortality in eating disorders: a descriptive study”, International Journal of Eating Disorders 28, 20–26.
   PubMed Web of Science ®Google Scholar
• Hibbeln, J.R. (2001 ) “Seafood consumption and homicide mortality. A cross-national ecological analysis”, World Review of Nutrition and Dietetics 88, 41–46.
   PubMedGoogle Scholar
• Hibbeln, J.R., Umhau, J.C., George, D.T. and Salem, N., Jr. (1997 ) “Do plasma polyunsaturates predict hostility and depression?”, World Review of Nutrition and Dietetics 82, 175–186.
   PubMed Web of Science ®Google Scholar
• Hibbeln, J.R., Umhau, J.C., Linnoila, M., George, D.T., Ragan, P.W., Shoaf, S.E., Vaughan, M.R., Rawlings, R. and Salem, N., Jr. (1998 ) “A replication study of violent and nonviolent subjects: cerebrospinal fluid metabolites of serotonin and dopamine are predicted by plasma essential fatty acids”, Biological Psychiatry 44, 243–249.
   PubMed Web of Science ®Google Scholar
• Holman, R.T., Adams, C.E., Nelson, R.A., Grater, S.J., Jaskiewicz, J.A., Johnson, S.B. and Erdman, J.W., Jr. (1995 ) “Patients with anorexia nervosa demonstrate deficiencies of selected essential fatty acids, compensatory changes in nonessential fatty acids and decreased fluidity of plasma lipids”, Journal of Nutrition 125, 901–907.
   PubMed Web of Science ®Google Scholar
• Hornstra, G. (2000 ) “Essential fatty acids in mothers and their neonates”, American Journal of Clinical Nutrition 71, 1262S–1269S.
   PubMed Web of Science ®Google Scholar
• Horrobin, D.F. and Cunnane, S.C. (1980 ) “Interactions between zinc, essential fatty acids and prostaglandins: relevance to acrodermatitis enteropathica, total parenteral nutrition, the glucagonoma syndrome, diabetes, anorexia nervosa and sickle cell anaemia”, Medical Hypotheses 6, 277–296.
   PubMed Web of Science ®Google Scholar
• Horrobin, D.F. and Bennett, C.N. (1999 ) “Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological abnormalities, cancer, ageing and osteoporosis. Possible candidate genes”, Prostaglandins Leukotrienes and Essential Fatty Acids 60, 217–234.
   PubMed Web of Science ®Google Scholar
• Horrobin, D.F., Glen, A.I. and Vaddadi, K. (1994 ) “The membrane hypothesis of schizophrenia”, Schizophrenia Research 13, 195–207.
   PubMed Web of Science ®Google Scholar
• Hsu, L.K. (1997 ) “Can dieting cause an eating disorder?”, Psychological Medicine 27, 509–513.
   PubMed Web of Science ®Google Scholar
• Janeckova, R. (2001 ) “The role of leptin in human physiology and pathophysiology”, Physiological Research 50, 443–459.
   PubMed Web of Science ®Google Scholar
• Joy, C.B., Mumby-Croft, R. and Joy, L.A. (2003) “Polyunsaturated fatty acid supplementation for schizophrenia”, Cochrane Database of Systematic Reviews, [update of Cochrane Database Syst Rev., (2), CD001257; PMID: 10796622], CD001257.
   Google Scholar
• Kang, J.X. and Leaf, A. (2000 ) “Prevention of fatal cardiac arrhythmias by polyunsaturated fatty acids”, American Journal of Clinical Nutrition 71, 202S–207S.
   PubMed Web of Science ®Google Scholar
• Karmali, R.A. (1996 ) “Historical perspective and potential use of n-3 fatty acids in therapy of cancer cachexia”, Nutrition 12, S2–S4.
   PubMed Web of Science ®Google Scholar
• Kato, T., Shioiri, T., Murashita, J. and Inubushi, T. (1997 ) “Phosphorus-31 magnetic resonance spectroscopic observations in 4 cases with anorexia nervosa”, Progress in NeuroPsychopharmacology and Biological Psychiatry 21, 719–724.
   PubMed Web of Science ®Google Scholar
• Kaye, W.H., Nagata, T., Weltzin, T.E., Hsu, L.K., Sokol, M.S., McConaha, C., Plotnicov, K.H., Weise, J. and Deep, D. (2001 ) “Double-blind placebo-controlled administration of fluoxetine in restricting- and restricting-purging-type anorexia nervosa”, Biological Psychiatry 49, 644–652.
   PubMed Web of Science ®Google Scholar
• Keel, P.K., Dorer, D.J., Eddy, K.T., Franko, D., Charatan, D.L. and Herzog, D.B. (2003 ) “Predictors of Mortality in Eating Disorders”, Archives of General Psychiatry 60, 179–183.
   PubMed Web of Science ®Google Scholar
• Kelley, D.S. (2001 ) “Modulation of human immune and inflammatory responses by dietary fatty acids”, Nutrition 17, 669–673.
   PubMed Web of Science ®Google Scholar
• Klump, K.L., Kaye, W.H. and Strober, M. (2001 ) “The evolving genetic foundations of eating disorders”, Psychiatric Clinics of North America 24, 215–225.
   PubMed Web of Science ®Google Scholar
• Kopp, W., Blum, W.F., von Prittwitz, S., Ziegler, A., Lubbert, H., Emons, G., Herzog, W., Herpertz, S., Deter, H.C., Remschmidt, H. and Hebebrand, J. (1997 ) “Low leptin levels predict amenorrhea in underweight and eating disordered females”, Molecular Psychiatry 2, 335–340.
   PubMed Web of Science ®Google Scholar
• Kris-Etherton, P.M., Taylor, D.S., Yu-Poth, S., Huth, P., Moriarty, K., Fishell, V., Hargrove, R.L., Zhao, G. and Etherton, T.D. (2000 ) “Polyunsaturated fatty acids in the food chain in the United States”, American Journal of Clinical Nutrition 71, 179S–188S.
   PubMed Web of Science ®Google Scholar
• Kruger, M.C. and Horrobin, D.F. (1997 ) “Calcium metabolism, osteoporosis and essential fatty acids: a review”, Progress in Lipid Research 36, 131–151.
   PubMed Web of Science ®Google Scholar
• Kruger, M.C., Coetzer, H., de Winter, R., Gericke, G. and van Papendorp, D.H. (1998 ) “Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis”, Aging (Milano) 10, 385–394.
   PubMedGoogle Scholar
• Langan, S.M. and Farrell, P.M. (1985 ) “Vitamin E, vitamin A and essential fatty acid status of patients hospitalized for anorexia nervosa”, American Journal of Clinical Nutrition 41, 1054–1060.
   PubMed Web of Science ®Google Scholar
• Lask, B., Fosson, A., Rolfe, U. and Thomas, S. (1993 ) “Zinc deficiency and childhood-onset anorexia nervosa”, Journal of Clinical Psychiatry 54, 63–66.
   PubMed Web of Science ®Google Scholar
• Lear, S.A., Pauly, R.P. and Birmingham, C.L. (1999 ) “Body fat, caloric intake, and plasma leptin levels in women with anorexia nervosa”, International Journal of Eating Disorders 26, 283–288.
   PubMed Web of Science ®Google Scholar
• Li, D., Sinclair, A., Wilson, A., Nakkote, S., Kelly, F., Abedin, L., Mann, N. and Turner, A. (1999 ) “Effect of dietary alpha- linolenic acid on thrombotic risk factors in vegetarian men”, American Journal of Clinical Nutrition 69, 872–882.
   PubMed Web of Science ®Google Scholar
• Lucas, A.R., Beard, C.M., O’Fallon, W.M. and Kurland, L.T. (1991 ) “50-year trends in the incidence of anorexia nervosa in Rochester, Minn.: a population-based study”, American Journal of Psychiatry 148, 917–922.
   PubMed Web of Science ®Google Scholar
• Maes, M., Christophe, A., Bosmans, E., Lin, A. and Neels, H. (2000 ) “In humans, serum polyunsaturated fatty acid levels predict the response of proinflammatory cytokines to psychologic stress”, Biological Psychiatry 47, 910–920.
   PubMed Web of Science ®Google Scholar
• Mantzoros, C.S. (2000 ) “Role of leptin in reproduction”, Annals of the New York Academy of Sciences 900, 174–183.
   PubMed Web of Science ®Google Scholar
• Mehler, P.S., Lezotte, D. and Eckel, R. (1998 ) “Lipid levels in anorexia nervosa”, International Journal of Eating Disorders 24, 217–221.
   PubMed Web of Science ®Google Scholar
• Mezzano, D., Kosiel, K., Martinez, C., Cuevas, A., Panes, O., Aranda, E., Strobel, P., Perez, D.D., Pereira, J., Rozowski, J. and Leighton, F. (2000 ) “Cardiovascular risk factors in vegetarians. Normalization of hyperhomocysteinemia with vitamin B(12) and reduction of platelet aggregation with n-3 fatty acids”, Thrombosis Research 100, 153–160.
   PubMed Web of Science ®Google Scholar
• Munoz, M.T., Morande, G., Garcia-Centenera, J.A., Hervas, F., Pozo, J. and Argente, J. (2002 ) “The effects of estrogen administration on bone mineral density in adolescents with anorexia nervosa”, European Journal of Endocrinology 146, 45–50.
   PubMed Web of Science ®Google Scholar
• Nakamura, K., Yamamoto, M., Yamazaki, O., Kawashima, Y., Muto, K., Someya, T., Sakurai, K. and Nozoe, S. (2000 ) “Prevalence of anorexia nervosa and bulimia nervosa in a geographically defined area in Japan”, International Journal of Eating Disorders 28, 173–180.
   PubMed Web of Science ®Google Scholar
• Nakamura, M.T., Cho, H.P., Xu, J., Tang, Z. and Clarke, S.D. (2001 ) “Metabolism and functions of highly unsaturated fatty acids: an update”, Lipids 36, 961–964.
   PubMed Web of Science ®Google Scholar
• Nemets, B., Stahl, Z. and Belmaker, R.H. (2002 ) “Addition of Omega-3 Fatty Acid to Maintenance Medication Treatment for Recurrent Unipolar Depressive Disorder”, American Journal of Psychiatry 159, 477–479.
   PubMed Web of Science ®Google Scholar
• Neumark-Sztainer, D., Story, M., Resnick, M.D. and Blum, R.W. (1997 ) “Adolescent vegetarians. A behavioral profile of a school-based population in Minnesota”, Archives of Pediatrics and Adolescent Medicine 151, 833–838.
   PubMedGoogle Scholar
• Nielsen, S. (1990 ) “The epidemiology of anorexia nervosa in Denmark from 1973 to 1987, a nationwide register study of psychiatric admission”, Acta Psychiatrica Scandinavica 81, 507–514.
   PubMed Web of Science ®Google Scholar
• Nielsen, S., Moller-Madsen, S., Isager, T., Jorgensen, J. and Pagsberg, K. (1998 ) “Standardized mortality in eating disorders—a quantitative summary of previously published and new evidence”, Journal of Psychosomatic Research 44, 413–434.
   PubMed Web of Science ®Google Scholar
• O’Connor, M.A., Touyz, S.W., Dunn, S.M. and Beumont, PJ. (1987 ) “Vegetarianism in anorexia nervosa? A review of 116 consecutive cases”, Medical Journal of Australia 147, 540–542.
   PubMed Web of Science ®Google Scholar
• Olsen, S.F., Secher, N.J., Tabor, A., Weber, T., Walker, J.J. and Gluud, C. (2000 ) “Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials In Pregnancy (FOTIP) Team”, British Journal of Obstetrics and Gynaecology 107, 382–395.
   Google Scholar
• Peet, M. and Horrobin, D.F. (2002 ) “A dose-ranging study of the effects of Ethyl-Eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs”, Archives of General Psychiatry 59, 913–919.
   PubMed Web of Science ®Google Scholar
• Peet, M., Horrobin, D.F. and Study Group E.-E.M. (2002) “A dose- ranging exploratory study of the effects of ethyl-eicosapen- taenoate in patients with persistent schizophrenic symptoms”, Journal of Psychiatric Research 36, 7–18.
   PubMed Web of Science ®Google Scholar
• Peet, M., Glen, I. and Horrobin, D.F. (1999) Phospholipid spectrum disorder in psychiatry (Marius Press).
   Google Scholar
• Perry, C.L., McGuire, M.T., Neumark-Sztainer, D. and Story, M. (2001 ) “Characteristics of vegetarian adolescents in a multiethnic urban population”, Journal of Adolescent Health 29, 406–416.
   PubMed Web of Science ®Google Scholar
• Puri, B.K. and Richardson, A.J. (1998 ) “Sustained remission of positive and negative symptoms of schizophrenia following treatment with eicosapentaenoic acid”, Archives of General Psychiatry 55, 188–189.
   PubMed Web of Science ®Google Scholar
• Puri, B.K., Richardson, A.J., Horrobin, D.F., Easton, T., Saeed, N., Oatridge, A., Hajnal, J.V. and Bydder, G.M. (2000 ) “Eico- sapentaenoic acid treatment in schizophrenia associated with symptom remission, normalisation of blood fatty acids, reduced neuronal membrane phospholipid turnover and structural brain changes”, International Journal of Clinical Practice 54, 57–63.
   PubMed Web of Science ®Google Scholar
• Puri, B.K., Counsell, S.J., Hamilton, G., Richardson, A.J. and Horrobin, D.F. (2001 ) “Eicosapentaenoic acid in treatment- resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover”, International Journal of Clinical Practice 55, 560–563.
   PubMed Web of Science ®Google Scholar
• Puri, B.K., Counsell, S.J., Richardson, A.J. and Horrobin, D.F. (2002 ) “Eicosapentaenoic acid in treatment-resistant depression”, Archives of General Psychiatry 59, 91–99 a.
   PubMedGoogle Scholar
• Rapoport, S.I. (2001) “In vivo fatty acid incorporation into brain phosholipids in relation to plasma availability, signal transduction and membrane remodeling”, Journal of Molecular Neuroscience 16, 243–261.
   PubMed Web of Science ®Google Scholar
• Requirand, P., Gibert, P., Tramini, P., Cristol, J.P. and Descomps, B. (2000 ) “Serum fatty acid imbalance in bone loss: example with periodontal disease”, Clinical Nutrition 19, 271–276.
   PubMed Web of Science ®Google Scholar
• Reseland, J.E., Haugen, F., Hollung, K., Solvoll, K., Halvorsen, B., Brude, I.R., Nenseter, M.S., Christiansen, E.N. and Drevon, C.A. (2001 ) “Reduction of leptin gene expression by dietary polyunsaturated fatty acids”, Journal of Lipid Research 42, 743–750.
   PubMed Web of Science ®Google Scholar
• Rink, L. and Gabriel, P. (2000 ) “Zinc and the immune system”, Proceedings of the Nutrition Society 59, 541–552.
   PubMed Web of Science ®Google Scholar
• Robertson, M.D., Jackson, K.G., Fielding, B.A., Morgan, L.M., Williams, C.M. and Frayn, K.N. (2002 ) “Acute ingestion of a meal rich in n-3 polyunsaturated fatty acids results in rapid gastric emptying in humans”, American Journal of Clinical Nutrition 76, 232–238.
   PubMed Web of Science ®Google Scholar
• Robinson, E., Bachrach, L.K. and Katzman, D.K. (2000 ) “Use of hormone replacement therapy to reduce the risk of osteopenia in adolescent girls with anorexia nervosa”, Journal of Adolescent Health 26, 343–348.
   PubMed Web of Science ®Google Scholar
• Rooney, B., McClelland, L., Crisp, A.H. and Sedgwick, P.M. (1995 ) “The incidence and prevalence of anorexia nervosa in three suburban health districts in south west London, U.K.”, International Journal of Eating Disorders 18, 299–307.
   PubMed Web of Science ®Google Scholar
• Roser, W., Bubl, R., Buergin, D., Seelig, J., Radue, E.W. and Rost, B. (1999 ) “Metabolic changes in the brain of patients with anorexia and bulimia nervosa as detected by proton magnetic resonance spectroscopy”, International Journal of Eating Disorders 26, 119–136.
   PubMed Web of Science ®Google Scholar
• Russell, G.F., Treasure, J. and Eisler, I. (1998 ) “Mothers with anorexia nervosa who underfeed their children: their recognition and management”, Psychological Medicine 28, 93–108.
   PubMed Web of Science ®Google Scholar
• Safai-Kutti, S. (1990 ) “Oral zinc supplementation in anorexia nervosa”, Acta Psychiatrica Scandinavica, Supplementum 361, 14–17.
   PubMedGoogle Scholar
• Sakaguchi, K., Morita, I. and Murota, S. (1994 ) “Eicosapentaenoic acid inhibits bone loss due to ovariectomy in rats”, Prostaglandins Leukotrienes and Essential Fatty Acids 50, 81–84.
   PubMed Web of Science ®Google Scholar
• Sanchez-Muniz, F.J., Marcos, A. and Varela, P. (1991 ) “Serum lipids and apolipoprotein B values, blood pressure and pulse rate in anorexia nervosa”, European Journal of Clinical Nutrition 45, 33–36.
   PubMed Web of Science ®Google Scholar
• Sanders, T.A. (1999 ) “Essential fatty acid requirements of vegetarians in pregnancy, lactation, and infancy”, American Journal of Clinical Nutrition 70, 555S–559S.
   PubMed Web of Science ®Google Scholar
• Schloss, I., Kidd, M.S., Tichelaar, H.Y., Young, G.O. and O’Keefe, S.J. (1997 ) “Dietary factors associated with a low risk of colon cancer in coloured west coast fishermen”, South African Medical Journal 87, 152–158.
   PubMed Web of Science ®Google Scholar
• Schmidt, U., Tiller, J., Blanchard, M., Andrews, B. and Treasure, J. (1997 ) “Is there a specific trauma precipitating anorexia nervosa?”, Psychological Medicine 27, 523–530.
   PubMed Web of Science ®Google Scholar
• Shay, N.F. and Mangian, H.F. (2000 ) “Neurobiology of zinc- influenced eating behavior”, Journal of Nutrition 130, 1493S–1499S.
   PubMed Web of Science ®Google Scholar
• Simopoulos, A.P. (1989 ) “Summary of the NATO advanced research workshop on dietary omega 3 and omega 6 fatty acids: biological effects and nutritional essentiality”, Journal of Nutrition 119, 521–528.
   PubMed Web of Science ®Google Scholar
• Simopoulos, A.P. (2002a ) “Omega-3 fatty acids in inflammation and autoimmune diseases”, Journal of the American College of Nutrition 21, 495–505.
   PubMed Web of Science ®Google Scholar
• Simopoulos, A.P. (2002b ) “The importance of the ratio of omega-6/omega-3 essential fatty acids”, Biomedicine and Pharmacotherapy 56, 365–379.
   PubMed Web of Science ®Google Scholar
• Sokol, M.S. (2000 ) “Infection-triggered anorexia nervosa in children: clinical description of four cases”, Journal of Child and Adolescent Psychopharmacology 10, 133–145.
   PubMed Web of Science ®Google Scholar
• Steinhausen, H.C. (2002 ) “The outcome of anorexia nervosa in the 20th century”, American Journal of Psychiatry 159, 1284–1293.
   PubMed Web of Science ®Google Scholar
• Stoll, A.L., Severus, W.E., Freeman, M.P., Rueter, S., Zboyan, H.A., Diamond, E., Cress, K.K. and Marangell, L.B. (1999 ) “Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial”, Archives of General Psychiatry 56, 407–412.
   PubMed Web of Science ®Google Scholar
• Strober, M., Pataki, C., Freeman, R. and DeAntonio, M. (1999 ) “No effect of adjunctive fluoxetine on eating behavior or weight phobia during the inpatient treatment of anorexia nervosa: an historical case-control study”, Journal of Child and Adolescent Psychopharmacology 9, 195–201.
   PubMed Web of Science ®Google Scholar
• Strumia, R., Varotti, E., Manzato, E. and Gualandi, M. (2001 ) “Skin signs in anorexia nervosa”, Dermatology 203, 314–317.
   PubMed Web of Science ®Google Scholar
• Sugano, M. and Ikeda, I. (1996 ) “Metabolic interactions between essential and trans-fatty acids”, Current Opinion in Lipidology 7, 38–42.
   PubMed Web of Science ®Google Scholar
• Takeda, A. (2001 ) “Zinc homeostasis and functions of zinc in the brain”, Biometals 14, 343–351.
   PubMed Web of Science ®Google Scholar
• Tanskanen, A., Hibbeln, J.R., Tuomilehto, J., Uutela, A., Haukkala, A., Spacing, D., Lehtonen, J. and Vartiainen, E. (2001 ) “Fish consumption and depressive symptoms in the general population in Finland”, Psychiatric Services 52, 529–531.
   PubMed Web of Science ®Google Scholar
• Terano, T. (2001 ) “Effect of omega 3 polyunsaturated fatty acid ingestion on bone metabolism and osteoporosis”, World Review of Nutrition and Dietetics 88, 141–147.
   PubMedGoogle Scholar
• Tisdale, M.J. (1996 ) “Inhibition of lipolysis and muscle protein degradation by EPA in cancer cachexia”, Nutrition 12, S31–S33.
   PubMed Web of Science ®Google Scholar
• Treasure, J. and Serpell, L. (1999 ) “Osteoporosis in anorexia nervosa”, Hospital Medicine (London) 60, 477–480.
   Web of Science ®Google Scholar
• Treasure, J. and Serpell, L. (2001 ) “Osteoporosis in young people. Research and treatment in eating disorders”, Psychiatric Clinics of North America 24, 359–370.
   PubMed Web of Science ®Google Scholar
• Tsai, G. (2000 ) “Eating disorders in the Far East. [Review] [136 refs]”, Eating & Weight Disorders: EWD 5, 183–197.
   PubMedGoogle Scholar
• Tsuge, H., Hotta, N. and Hayakawa, T. (2000 ) “Effects of vitamin B-6 on (n-3) polyunsaturated fatty acid metabolism”, Journal of Nutrition 130, 333S–334S.
   PubMed Web of Science ®Google Scholar
• Wade, T.D., Bulik, C.M., Neale, M. and Kendler, K.S. (2000 ) “Anorexia nervosa and major depression: shared genetic and environmental risk factors”, American Journal of Psychiatry 157, 469–471.
   PubMed Web of Science ®Google Scholar
• Ward, G., Woods, J., Reyzer, M. and Salem, Jr., N. (1996 ) “Artificial rearing of infant rats on milk formula deficient in n-3 essential fatty acids: a rapid method for the production of experimental n-3 deficiency”, Lipids 31, 71–77.
   PubMed Web of Science ®Google Scholar
• Watkins, B.A., Li, Y., Allen, K.G., Hoffmann, W.E. and Seifert, M.F. (2000 ) “Dietary ratio of (n-6)/(n-3) polyunsaturated fatty acids alters the fatty acid composition of bone compartments and biomarkers of bone formation in rats”, Journal of Nutrition 130, 2274–2284.
   PubMed Web of Science ®Google Scholar
• Watkins, B.A., Li, Y., Lippman, H.E. and Seifert, M.F. (2001 ) “Omega-3 polyunsaturated fatty acids and skeletal health”, Experimental Biology and Medicine 226, 485–497.
   PubMed Web of Science ®Google Scholar
• Wauben, I.P., Xing, H.C. and Wainwright, P.E. (1999 ) “Neonatal dietary zinc deficiency in artificially reared rat pups retards behavioral development and interacts with essential fatty acid deficiency to alter liver and brain fatty acid composition”, Journal of Nutrition 129, 1773–1781.
   PubMed Web of Science ®Google Scholar
• Waugh, E. and Bulik, C.M. (1999 ) “Offspring of women with eating disorders”, International Journal of Eating Disorders 25, 123–133.
   PubMed Web of Science ®Google Scholar
• Whitehouse, A.S. and Tisdale, M.J. (2001 ) “Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation”, Biochemical and Biophysical Research Communications 285, 598–602.
   PubMed Web of Science ®Google Scholar
• Wigmore, S.J., Barber, M.D., Ross, J.A., Tisdale, M.J. and Fearon, K.C. (2000 ) “Effect of oral eicosapentaenoic acid on weight loss in patients with pancreatic cancer”, Nutrition and Cancer 36, 177–184.
   PubMed Web of Science ®Google Scholar
• Winnicki, M., Somers, V.K., Accurso, V., Phillips, B.G., Puato, M., Palatini, P. and Pauletto, P. (2002 ) “Fish-rich diet, leptin, and body mass”, Circulation 106, 289–291.
   PubMed Web of Science ®Google Scholar
• Zanarini, M.C. and Frankenburg, F.R. (2003 ) “Omega-3 fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study”, American Journal of Psychiatry 160, 167–169.
   PubMed Web of Science ®Google Scholar
• Ziboh, V.A., Miller, C.C. and Cho, Y. (2000 ) “Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites”, American Journal of Clinical Nutrition 71, 361S–366S.
   PubMed Web of Science ®Google Scholar
• Zipfel, S., Seibel, M.J., Lowe, B., Beumont, P.J., Kasperk, C. and Herzog, W. (2001 ) “Osteoporosis in eating disorders: a follow-up study of patients with anorexia and bulimia nervosa”, Journal of Clinical Endocrinology and Metabolism 86, 5227–5233.
   PubMed Web of Science ®Google Scholar