Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 1, 1998 - Issue 6
6
Views
5
CrossRef citations to date
0
Altmetric
Original Articles

Chronic Diazepam Administration Failed to Induce Tolerance and Withdrawal Syndrome in Perinatally Undernourished Female Rats as Measured in the Open Field Drink Test

, , &
Pages 427-437 | Received 01 Jul 1998, Published online: 13 Jul 2016

References

  • Allan, A.M., Baier, L.D. and Zhang, X. (1992) Effects of lorazepam tolerance and withdrawal on GABAA receptoroperated chloride channels. Journal of Pharmacology and Experimental Therapeutics 261, 395–402.
  • Almeida, S.S., de Oliveira, L.M. and Graeff, F.G. (1990) Decreased reactivity to anxiolytics caused by early protein malnutrition in rats. Pharmacology Biochemistry and Behavior 36, 997–1000.
  • Almeida, S.S., de Oliveira, L.M. and Graeff, F.G. (1991) Early life protein malnutrition changes exploration of the elevated plus-maze and reactivity to anxiolytics. Psychopharmacology 103, 513–518.
  • Almeida, S.S., Soares, E.G., Bichuette, M.Z., Graeff, F.G. and de Oliveira, L.M. (1992) Effects of early postnatal malnutrition and chlordiazepoxide on experimental aversive situations. Physiology and Behavior 51, 1195–1199.
  • Almeida, S.S., Tonkiss, J. and Galler, J.R. (1996) Malnutrition and reactivity to drugs acting in the central nervous system. Neuroscience and Biobehavioral Reviews 20, 389–402.
  • Andrews, N. and File, S.E. (1993) Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioural evidence. Psychopharmacology 112, 21–25.
  • Andrews, N., File, S.E., Fernandes, C., Gonzalez, L.E. and Barnes, N.M. (1997) Evidence that the median raphé nucleus-dorsal hippocampal pathway mediates diazepam withdrawal-induced anxiety. Psychopharmacology 130, 228–234.
  • Biggio, G., Concas, A., Corda, M.G., Giorgi, O., Sanna, E. and Serra, M. (1990) GABAergic and dopaminergic transmission in the rat cerebral cortex: effect of stress, anxiolytic and anxiogenic drugs. Pharmacology and Therapeutics 48, 121–142.
  • Boix, F., Fernández-Teruel, A. and Tobeña, A. (1989) The anxiolytic action of benzodiazepines is not present in handling-habituated rats. Pharmacology Biochemistry and Behavior 31, 541–546.
  • Borghese, C.M., Córdoba, N.E., Laino, C.H., Orsingher, O.A., Rubio, M.C. and Niselman, V. (1998) Lack of tolerance to the anxiolytic effect of diazepam and pentobarbital following chronic administration in perinatally undernourished rats. Brain Research Bulletin 46, 237–244.
  • Braestrup, C., Honoré, T., Nielsen, M., Petersen, E.N. and Jensen, L.H. (1984) Ligands for benzodiazepine receptors with positive and negative efficacy. Biochemical Pharmacology 33, 859–862.
  • Brett, R.R. and Pratt, J.A. (1990) Chronic handling modifies the anxiolytic effect of diazepam in the elevated plus-maze. European Journal of Pharmacology 178, 135–138.
  • Brioni, J.D. and Orsingher, O.A. (1988) Operant behavior and reactivity to the anticonflict effect of diazepam in perinatally undernourished rats. Physiology and Behavior 44, 193–198.
  • Brioni, J.D., Córdoba, N. and Orsingher, O.A. (1989) Decreased reactivity to the anticonflict effect of diazepam in perinatally undernourished rats. Behavioral Brain Research 34, 159–162.
  • Córdoba, N.E., Pavcovich, L.A., Brioni, J.D. and Orsingher, O.A. (1990) Perinatal undernutrition alters different pharmacological effects of ethanol in adult recovered rats. Acta Physiologica et Pharmacologica Latinoamericana 40, 403–412.
  • Córdoba, N.E., Cuadra, G.R., Brioni, J.D. and Orsingher, O.A. (1992) Perinatal protein deprivation enhances the anticonflict effect measured after chronic ethanol determination in adult rats. The Journal of Nutrition 122, 1536–1541.
  • Córdoba, N.E., Borghese, C.M., Arolfo, M.P. and Orsingher, O.A. (1997) Reduced tolerance to certain pharmacological effects of ethanol after chronic administration in perinatally undernourished rats. Pharmacology Biochemistry and Behavior 57, 659–663.
  • File, S.E. (1990) The history of benzodiazepine dependence: a review of animal studies. Neuroscience and Biobehavioral Reviews 14, 135–146.
  • Frankova, S. and Barnes, R.H. (1968) Effect of malnutrition in early life on avoidance conditioning and behavior of adult rats. The Journal of Nutrition 96, 485–493.
  • Gutiérrez, A.C. and Keller, E.A. (1997) Analgesic response to stress is reduced in perinatally undernourished rats. The Journal of Nutrition 127, 765–769.
  • Harris, R.A. and Allan, A.M. (1985) Functional coupling of γ-aminobutyric acid receptors to chloride channels in brain membranes. Science 228, 1108–1110.
  • Keller, E.A., Cuadra, G.R., Molina, V.A. and Orsingher, O.A. (1990a) Perinatal undernutrition affects brain modulatory capacity of β-adrenergic receptors in adult rats. The Journal of Nutrition 120, 305–308.
  • Keller, E.A., Molina, V.A. and Orsingher, O.A. (1990b) Lack of neuronal adaptive changes following chronic treatments in perinatally undernourished rats. Pharmacology Biochemistry and Behavior 37, 675–678.
  • Keller, E.A., Cancela, L.M., Molina, V.A. and Orsingher, O.A. (1994) Lack of adaptive changes in 5-HT sites in perinatally undernourished rats after chronic stress: opioid influence. Pharmacology Biochemistry and Behavior 47, 789–793.
  • Laino, C.H., Córdoba, N.E. and Orsingher, O.A. (1993) Perinatally protein-deprived rats and reactivity to anxiolytic drugs in the plus-maze test: an animal model for screening antipanic agents? Pharmacology Biochemistry and Behavior 46, 89–94.
  • Levitsky, D.A. and Barnes, R.H. (1970) Effect of early malnutrition on the reaction of adult rats to aversive stimuli. Nature 225, 468–469.
  • Levitsky, D.A. and Strupp, B.J. (1995) Malnutrition and the brain: changing concepts, changing concerns. The Journal of Nutrition 125, 2212S–2220S.
  • Li, M., Rosenberg, H.C. and Chiu, T.H. (1993) Tolerance to the effects of diazepam, clonazepam and bretazenil on GABA-stimulated Cl- influx in flurazepam tolerant rats. European Journal of Pharmacology 247, 313–318.
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein mesurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265–275.
  • Marichich, E.S., Molina, V.A. and Orsingher, O.A. (1979) Persistent changes in central catecholaminergic system after recovery of perinatally undernourished rats. The Journal of Nutrition 109, 1045–1050.
  • Morgane, P.J., Austin-LaFrance, R., Bronzino, J., Tonkiss, J., Díaz-Cintra, S., Cintra, L., Kemper, T. and Galler, J.R. (1993) Prenatal malnutrition and development of the brain. Neuroscience and Biobehavioral Reviews 17, 91–128.
  • Primus, R.J. and Kellogg, C.K. (1991) Experience influences environmental modulation of function at the benzodiazepine (BZD)/GABA receptor chloride channel complex. Brain Research 545, 257–264.
  • Smart, J.L. (1971) Long-lasting effects of early malnutritional deprivation on the behavior of rodents. Psychiatria Neurologia Neurochirurgiam (Austria) 74, 443–452.
  • Sobotka, T.J., Cook M.P. and Brodie, R.E. (1974) Neonatal malnutrition: neurochemical, hormonal and behavioral manifestations. Brain Research 65, 443–457.
  • Stout, J.C. and Weiss, J.M. (1994) An animal model for measuring behavioral responses to anxiogenic and anxiolytic manipulations. Pharmacology Biochemistry and Behavior 47, 459–465.
  • Toki, S., Saito, T., Hatta, S. and Takahata, N. (1996) Diazepam physical dependence and withdrawal in rats is associated with alteration in GABAA receptor function. Life Sciences 59, 1631–1641.
  • Wiggins, R.C., Fuller, G. and Enna, S.J. (1984) Undernutrition and the development of brain neurotransmitter systems. Life Sciences 35, 2085–2094.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.