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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 22, 2019 - Issue 5
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Benefits and drawbacks of guanidinoacetic acid as a possible treatment to replenish cerebral creatine in AGAT deficiency

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References

  • Nasrallah F, Feki M, Kaabachi N. Creatine and creatine deficiency syndromes: biochemical and clinical aspects. Pediatr Neurol 2010;42:163–71. doi: 10.1016/j.pediatrneurol.2009.07.015
  • Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 2000;80:1107–213. doi: 10.1152/physrev.2000.80.3.1107
  • Item CB, Stöckler-Ipsiroglu S, Stromberger C, Mühl A, Alessandrì MG, Bianchi MC, et al. Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans. Am J Hum Genet 2001;69:1127–33. doi: 10.1086/323765
  • Stockler-Ipsiroglu S, Apatean D, Battini R, DeBrosse S, Dessoffy K, Edvardson S, et al. Arginine:glycine amidinotransferase (AGAT) deficiency: clinical features and long term outcomes in 16 patients diagnosed worldwide. Mol Genet Metab 2015;116:252–9. doi: 10.1016/j.ymgme.2015.10.003
  • McBreairty LE, Robinson JL, Furlong KR, Brunton JA, Bertolo RF. Guanidinoacetate is more effective than creatine at enhancing tissue creatine stores while consequently limiting methionine availability in Yucatan miniature pigs. PLoS One 2015;10:e0131563. doi: 10.1371/journal.pone.0131563
  • Ostojic SM, Ostojic J, Drid P, Vranes M. Guanidinoacetic acid versus creatine for improved brain and muscle creatine levels: a superiority pilot trial in healthy men. Appl Physiol Nutr Metab 2016;41;1005–7.
  • Braissant O, Bachmann C, Henry H. Expression and function of AGAT, GAMT and CT1 in the mammalian brain. Subcell Biochem 2007;46:67–81. doi: 10.1007/978-1-4020-6486-9_4
  • Tachikawa M, Ikeda S, Fujinawa J, Hirose S, Akanuma S, Hosoya K. γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats. PLoS One 2012;7:e32557. doi: 10.1371/journal.pone.0032557
  • Borsook H, Borsook Me. The biochemical basis of betaine-glycocyamine therapy. Ann West Med Surg 1951;5:825–9.
  • Borsook ME, Billig HK, Golseth JG. Betaine and glycocyamine in the treatment of disability resulting from acute anterior poliomyelitis. Ann West Med Surg 1952;6:423–7.
  • Higgins AR, Harper HA, Kline EF, Merrill RS, Jones RE, Smith TW, et al. Effects of creatine precursors in arthritis; clinical and metabolic study of glycocyamine and betaine. Calif Med 1952;77:14.
  • Watkins AL. Betaine and glycocyamine in treatment of poliomyelitis. N Engl J Med 1953;248:621–3. doi: 10.1056/NEJM195304092481501
  • Liversedge LA. Glycocyamine and betaine in motor-neurone disease. Lancet 1956;268:1136–8. doi: 10.1016/S0140-6736(56)90154-4
  • Tsubakihara Y, Suzuki A, Hayashi T, Shoji T, Togawa M, Okada N. The effect of guanidinoacetic acid supplementation in patients with chronic renal failure. In: Mori A, Ishida M, Clark JF, (eds.). Guanidino compounds in biology and medicine. Tokyo: Blackwell; 1999:5. p. 139–44.
  • Ostojic SM, Stojanovic M, Drid P, Hoffman JR, Sekulic D, Zenic N. Supplementation with guanidinoacetic acid in women with chronic fatigue syndrome. Nutrients 2016;8:72. doi: 10.3390/nu8020072
  • Ostojic SM. A new perspective to improve brain bioenergetics in disorders with functional GAMT and CT1. Biomed Pharmacother 2016;84:1833. doi: 10.1016/j.biopha.2016.10.088
  • Stöckler S, Hanefeld F, Frahm J. Creatine replacement therapy in guanidineoacetate methyltransferase deficiency, a novel inborn error of metabolism. Lancet 1996;348:789–90. doi: 10.1016/S0140-6736(96)04116-5
  • Ostojic SM. Guanidinoacetic acid as a performance-enhancing agent. Amino Acids 2016;48:1867–75. doi: 10.1007/s00726-015-2106-y
  • Stead LM, Au KP, Jacobs RL, Brosnan ME, Brosnan JT. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am J Physiol Endocrinol Metab 2001;281:E1095–100. doi: 10.1152/ajpendo.2001.281.5.E1095
  • Obeid R. The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients 2013;5:3481–95. doi: 10.3390/nu5093481
  • Zugno AI, Pereira LO, Mattos C, Scherer EB, Netto CA, Wyse AT. Guanidinoacetate administration increases acetylcholinesterase activity in striatum of rats and impairs retention of an inhibitory avoidance task. Metab Brain Dis 2008;23:189–98. doi: 10.1007/s11011-008-9085-6
  • Tachikawa M, Fujinawa J, Takahashi M, Kasai Y, Fukaya M, Sakai K, et al. Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant. J Neurochem 2008;107:768–78. doi: 10.1111/j.1471-4159.2008.05652.x
  • Hanna-El-Daher L, Béard E, Henry H, Tenenbaum L, Braissant O. Mild guanidinoacetate increase under partial guanidinoacetate methyltransferase deficiency strongly affects brain cell development. Neurobiol Dis 2015;79:14–27. doi: 10.1016/j.nbd.2015.03.029
  • Hanna-El-Daher L, Braissant O. Creatine synthesis and exchanges between brain cells: what can be learned from human creatine deficiencies and various experimental models? Amino Acids 2016;48:1877–95. doi: 10.1007/s00726-016-2189-0
  • Ostojic SM, Niess B, Stojanovic M, Obrenovic M. Creatine metabolism and safety profiles after six-week oral guanidinoacetic acid administration in healthy humans. Int J Med Sci 2013;10:141–7. doi: 10.7150/ijms.5125
  • Ostojic SM, Stojanovic M, Drid P, Hoffman JR. Dose-response effects of oral guanidinoacetic acid on serum creatine, homocysteine and B vitamins levels. Eur J Nutr 2014;53:1637–43. doi: 10.1007/s00394-014-0669-0
  • Smith AD, Refsum H. Homocysteine, B vitamins, and cognitive impairment. Annu Rev Nutr 2016;36:211–39. doi: 10.1146/annurev-nutr-071715-050947
  • Braissant O, Henry H. AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: a review. J Inherit Metab Dis 2008;31:230–9. doi: 10.1007/s10545-008-0826-9

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