Pomegranate supplementation improves cognitive and functional recovery following ischemic stroke: A randomized trial

References

• Cumming TB, Marshall RS, Lazar RM. Stroke, cognitive deficits, and rehabilitation: still an incomplete picture. Int J Stroke 2013;8(1):38–45. doi: 10.1111/j.1747-4949.2012.00972.x
   PubMed Web of Science ®Google Scholar
• Aviram M, Dornfeld L, Rosenblat M, Volkova N, Kaplan M, Coleman R, et al. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr 2000;71(5):1062–76. doi: 10.1093/ajcn/71.5.1062
   PubMed Web of Science ®Google Scholar
• Esmaillzadeh A, Tahbaz F, Gaieni I, Alavi-Majd H, Azadbakht L. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7(3):305–308. doi: 10.1089/jmf.2004.7.305
   PubMed Web of Science ®Google Scholar
• Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57(6):858–64. doi: 10.1203/01.PDR.0000157722.07810.15
   PubMed Web of Science ®Google Scholar
• West T, Atzeva M, Holtzman DM. Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury. Dev Neurosci 2007;29(4–5):363–72. doi: 10.1159/000105477
   PubMed Web of Science ®Google Scholar
• Ahmed MA, El Morsy EM, Ahmed AA. Pomegranate extract protects against cerebral ischemia/reperfusion injury and preserves brain DNA integrity in rats. Life Sci 2014;110(2):61–69. doi: 10.1016/j.lfs.2014.06.023
   PubMed Web of Science ®Google Scholar
• Sarkaki A, Rezaiei M. Improving active and passive avoidance memories deficits due to permanent cerebral ischemia by pomegranate seed extract in female rats. Malaysian J Med Sci: MJMS 2013;20(2):25.
   PubMedGoogle Scholar
• Gillman MW, Cupples LA, Gagnon D, Posner BM, Ellison RC, Castelli WP, et al. Protective effect of fruits and vegetables on development of stroke in men. JAMA 1995;273(14):1113–17. doi: 10.1001/jama.1995.03520380049034
   PubMed Web of Science ®Google Scholar
• Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, et al. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 1999;282(13):1233–39. doi: 10.1001/jama.282.13.1233
   PubMed Web of Science ®Google Scholar
• Bookheimer SY, Renner BA, Ekstrom A, Li Z, Henning SM, Brown JA, et al. Pomegranate juice augments memory and FMRI activity in middle-aged and older adults with mild memory complaints. Evid-Based Compl Alt 2013;2013:1–14. doi: 10.1155/2013/946298
   Web of Science ®Google Scholar
• Ropacki SA, Patel SM, Hartman RE. Pomegranate supplementation protects against memory dysfunction after heart surgery: a pilot study. Evid-Based Compl Alt 2013;2013:1–8. doi: 10.1155/2013/932401
   Web of Science ®Google Scholar
• Panickar KS, Anderson RA. Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia. Int J Mol Sci 2011;12(11):8181–207. doi: 10.3390/ijms12118181
   PubMed Web of Science ®Google Scholar
• Castillo J, Dávalos A, Noya M. Progression of ischaemic stroke and excitotoxic aminoacids. Lancet 1997;349(9045):79–82. doi: 10.1016/S0140-6736(96)04453-4
   PubMed Web of Science ®Google Scholar
• Seeram NP, Zhang Y, McKeever R, Henning SM, Lee R-P, Suchard MA, et al. Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. J Med Food 2008;11(2):390–94. doi: 10.1089/jmf.2007.650
   PubMed Web of Science ®Google Scholar
• Wilde MC. The validity of the repeatable battery of neuropsychological status in acute stroke. Clin Neuropsychol. 2006;20(4):702–15. doi: 10.1080/13854040500246901
   PubMed Web of Science ®Google Scholar
• Larson EB, Kirschner K, Bode R, Heinemann A, Goodman R. Construct and predictive validity of the repeatable battery for the assessment of neuropsychological status in the evaluation of stroke patients. J Clin Exp Neuropsyc. 2005;27(1):16–32. doi: 10.1080/138033990513564
   PubMed Web of Science ®Google Scholar
• Cramer SC. Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery. Ann Neurol 2008;63(3):272–87. doi: 10.1002/ana.21393
   PubMed Web of Science ®Google Scholar
• Zhang RL, Zhang ZG, Chopp M. Ischemic stroke and neurogenesis in the subventricular zone. Neuropharmacology 2008;55(3):345–52. doi: 10.1016/j.neuropharm.2008.05.027
   PubMed Web of Science ®Google Scholar
• Dulcich MS, Hartman RE. Pomegranate supplementation improves affective and motor behavior in mice after radiation exposure. Evid-Based Compl Alt 2013;2013:1–8. doi: 10.1155/2013/940830
   Google Scholar
• Hartman RE, Shah A, Fagan AM, Schwetye KE, Parsadanian M, Schulman RN, et al. Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer’s disease. Neurobiol Dis 2006;24(3):506–15. doi: 10.1016/j.nbd.2006.08.006
   PubMed Web of Science ®Google Scholar
• Rodriguez J, Caille O, Ferreira D, Francaux M. Pomegranate extract prevents skeletal muscle of mice against wasting induced by acute TNF-α injection. Mol Nutr Food Res 2017;61(4). DOI:10.1002/mnfr.201600169.
   Web of Science ®Google Scholar
• Ammar A, Turki M, Chtourou H, Hammouda O, Trabelsi K, Kallel C, et al. Pomegranate supplementation accelerates recovery of muscle damage and soreness and inflammatory markers after a weightlifting training session. PloS one 2016;11(10):e0160305. doi: 10.1371/journal.pone.0160305
   PubMed Web of Science ®Google Scholar
• Trombold JR, Reinfeld AS, Casler JR, Coyle EF. The effect of pomegranate juice supplementation on strength and soreness after eccentric exercise. J Strength Cond Res 2011;25(7):1782–88. doi: 10.1519/JSC.0b013e318220d992
   PubMed Web of Science ®Google Scholar
• Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003;78(3):517S–520S. doi: 10.1093/ajcn/78.3.517S
   PubMed Web of Science ®Google Scholar
• Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem 2005;16(6):360–67. doi: 10.1016/j.jnutbio.2005.01.006
   PubMed Web of Science ®Google Scholar