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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 23, 2020 - Issue 8
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Articles

Several targets involved in Alzheimer’s disease amyloidogenesis are affected by morin and isoquercitrin

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References

  • Zheng H, Koo EH. Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener. 2011;6(1):27.
  • Epis R, Marcello E, Gardoni F, Di Luca M. Alpha, beta-and gamma-secretases in Alzheimer’s disease. Front Biosci (Schol Ed). 2012;4:1126–50.
  • Bolognesi ML, Bartolini M, Tarozzi A, Morroni F, Lizzi F, Milelli A, et al. Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity. Bioorg Med Chem Lett. 2011;21(9):2655–8.
  • Albarracin SL, Stab B, Casas Z, Sutachan JJ, Samudio I, Gonzalez J, et al. Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci. 2012;15(1):1–9.
  • Oddo S. The ubiquitin-proteasome system in Alzheimer’s disease. J Cell Mol Med. 2008;12(2):363–73.
  • Beking K, Vieira A. Flavonoid intake and disability-adjusted life years due to Alzheimer’s and related dementias: a population-based study involving twenty-three developed countries. Public Health Nutr. 2010;13(9):1403–9.
  • Jimenez-Aliaga K, Bermejo-Bescos P, Benedi J, Martin-Aragon S. Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells. Life Sci. 2011;89(25–26):939–45.
  • Hwang SL, Shih PH, Yen GC. Neuroprotective effects of citrus flavonoids. J Agric Food Chem. 2012;60(4):877–85.
  • Campos-Esparza MR, Sanchez-Gomez MV, Matute C. Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols. Cell Calcium 2009;45(4):358–68.
  • Valentova K, Vrba J, Bancirova M, Ulrichova J, Kren V. Isoquercitrin: pharmacology, toxicology, and metabolism. Food Chem Toxicol. 2014;68:267–82.
  • Prior M, Chiruta C, Currais A, Goldberg J, Ramsey J, Dargusch R, et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014;5(7):503–13.
  • Hong HS, Maezawa I, Yao N, Xu B, Diaz-Avalos R, Rana S, et al. Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity. Brain Res. 2007;1130(1):223–34.
  • Millucci L, Ghezzi L, Bernardini G, Santucci A. Conformations and biological activities of amyloid beta peptide 25–35. Curr Protein Pept Sci. 2010;11:54–67.
  • Naldi M, Fiori J, Pistolozzi M, Drake AF, Bertucci C, Wu R, et al. Amyloid β-peptide 25-35 self-assembly and its inhibition: a model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatment. ACS Chem Neurosci. 2012;3(11):952–62.
  • Marques CA, Keil U, Bonert A, Steiner B, Haass C, Muller WE, et al. Neurotoxic mechanisms caused by the Alzheimer’s disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway. J Biol Chem. 2003;278(30): 28294–302.
  • Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H. Flavonols and flavones as BACE-1 inhibitors: Structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. Biochim Biophys Acta 2008;1780(5):819–25.
  • Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L. Gamma-secretase inhibitors and modulators. Biochim Biophys Acta 2013;1828(12):2898–907.
  • Okumura N, Yoshida H, Nishimura Y, Murakami M, Kitagishi Y, Matsuda S. Genistein downregulates presenilin 1 and ubiquilin 1 expression. Mol Med Rep. 2012;5(2):559–61.
  • Rezai-Zadeh K, Douglas Shytle R, Bai Y, Tian J, Hou H, Mori T, et al. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. J Cell Mol Med. 2009;13(3):574–88.
  • Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M. Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem. 2003;87(1):172–81.
  • Uriarte-Pueyo I, Calvo MI. Flavonoids as Acetylcholinesterase Inhibitors. Curr Medicin Chem 2011;18(34):5289–302.
  • Xie Y, Yang W, Chen X, Xiao J. Inhibition of flavonoids on acetylcholine esterase: binding and structure-activity relationship. Food Funct. 2014;5(10):2582–9.
  • Sheng R, Lin X, Zhang J, Chol KS, Huang W, Yang B, et al. Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors. Bioorg Med Chem. 2009;17(18):6692–8.
  • Clark TA, Lee HP, Rolston RK, Zhu X, Marlatt MW, Castellani RJ, et al. Oxidative stress and its implications for future treatments and management of Alzheimer disease. Int J Biomed Sci. 2010;6(3):225–7.
  • Leuner K, Schutt Y, Kurz C, Eckert SH, Schiller C, Occhipinti A, et al. Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal 2012;16(12):1421–33.
  • Sekher Pannala A, Chan TS, O'Brien PJ, Rice-Evans CA. Flavonoid B-ring chemistry and antioxidant activity: fast reaction kinetics. Biochem Biophys Res Commun. 2001;282(5):1161–68.
  • Ben Sghaier M, Skandrani I, Nasr N, Franca MG, Chekir-Ghedira L, Ghedira K. Flavonoids and sesquiterpenes from Tecurium ramosissimum promote antiproliferation of human cancer cells and enhance antioxidant activity: a structure-activity relationship study. Environ Toxicol Pharmacol. 2011;32(3):336–48.
  • Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med. 1996;20(7):933–56.
  • Jazvinscak Jembrek M, Vukovic L, Puhovic J, Erhardt J, Orsolic N. Neuroprotective effect of quercetin against hydrogen peroxide-induced oxidative injury in P19 neurons. J Mol Neurosci. 2012;47(2):286–99.
  • Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. The role of caspase cleavage of tau in Alzheimer disease neuropathology. J Neuropathol Exp Neurol. 2005;64(2):104–12.
  • Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, et al. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004;114(1):121–30.
  • Dennissen FJ, Kholod N, van Leeuwen FW. The ubiquitin proteasome system in neurodegenerative diseases: culprit, accomplice or victim? Prog Neurobiol. 2012;96(2):190–207.
  • Reinheckel T, Sitte N, Ullrich O, Kuckelkorn U, Davies KJ, Grune T. Comparative resistance of the 20S and 26S proteasome to oxidative stress. Biochem J. 1998;335(Pt 3):637–42.
  • Wang X, Yen J, Kaiser P, Huang L. Regulation of the 26S proteasome complex during oxidative stress. Sci Signal 2010;3(151): ra88. doi: 10.1126/scisignal.2001232
  • Reinheckel T, Grune T, Davies KJ. The measurement of protein degradation in response to oxidative stress. Methods Mol Biol. 2000;99:49–60.
  • Kwak MK, Cho JM, Huang B, Shin S, Kensler TW. Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. Free Radic Biol Med. 2007;43(5):809–17.
  • Malhotra S, Suri S, Tuli R. Antioxidant activity of citrus cultivars and chemical composition of Citrus karna essential oil. Planta Med. 2009;75(1):62–4.
  • Fahey JW, Talalay P. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. Food Chem Toxicol. 1999;37(9–10):973–9.
  • Evans P, Halliwell B. Micronutrients: oxidant/antioxidant status. Br J Nutr. 2011;85(Suppl 2):S67–74.
  • Kwak MK, Huang B, Chang H, Kim JA, Kensler TW. Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein. Life Sci. 2007;80(26):2411–20.
  • Yuan Q, Wang CW, Shi J, Lin ZX. Effects of Ginkgo biloba on dementia: An overview of systematic reviews. J Ethnopharmacol. 2017;195:1–9.
  • Zhu J, Cui W, Xiao W, Ding Y, Huang W, Tu P, Wang Y. Isolation and enrichment of Ginkgo biloba extract by a continuous chromatography system. J Sep Sci. 2018;41(11):2432–40.
  • USDA Database for the Flavonoid Content of Selected Foods, Release 3.1, 2014.
  • Swaminathan A, Jicha GA. Nutrition and prevention of Alzheimer's dementia. Front Aging Neurosci. 2014;6:282.

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