References
- Koponen JM, Happonen AM, Mattila PH, Torronen AR. Contents of anthocyanins and ellagitannins in selected foods consumed in Finland. J Agric Food Chem. 2007;55:1612–9.
- Farbood Y, Sarkaki A, Dianat M, Khodadadi A, Haddad MK, Mashhadizadeh S. Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury. Life Sci. 2015;124:120–7. doi:10.1016/j.lfs.2015.01.013.
- Joseph SV, Edirisinghe I, Burton-Freeman BM. Berries: anti-inflammatory effects in humans. J Agric Food Chem. 2014;62(18):3886–903. doi:10.1021/jf4044056.
- Xu HL, Wang XT, Cheng Y, Zhao JG, Zhou YJ, Yang JJ, et al. Ursolic acid improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-induced rats. Biomed Pharmacother. 2018;105:915–21. doi:10.1016/j.biopha.2018.06.055.
- Skrovankova S, Sumczynski D, Mlcek J, Jurikova T, Sochor J. Bioactive compounds and antioxidant activity in different types of berries. Int J Molecular Sci. 2015;16(10):24673–706. doi:10.3390/ijms161024673.
- Gildawie KR, Galli RL, Shukitt-Hale B, Carey AN. Protective effects of foods containing flavonoids on age-related cognitive decline. Curr Nutr Rep. 2018;7(2):39–48. doi:10.1007/s13668-018-0227-0.
- Cordner ZA, Tamashiro KL. Effects of high-fat diet exposure on learning & memory. Physiol Behav. 2015;152:363–71.
- Freeman LR, Haley-Zitlin V, Rosenberger DS, Granholm AC. Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms. Nutr Neurosci. 2014;17:241–51.
- Beilharz JE, Maniam J, Morris MJ. Diet-induced cognitive deficits: the role of fat and sugar, potential mechanisms and nutritional interventions. Nutrients. 2015;7(8):6719–38. doi:10.3390/nu7085307.
- Carey AN, Galli RL. Mitigating the effects of high fat diet on the brain and behavior with berry supplementation. Food Funct. 2017;11:3869–78. doi:10.1039/c7fo00888k.
- Carey AN, Gomes SM, Shukitt-Hale B. Blueberry supplementation improves memory in middle-aged mice fed a high-fat diet. J Agric Food Chem. 2014;62:3972–8. doi: 10.1021/jf404565s
- Carey AN, Gildawie KR, Rovnak A, Thangthaeng N, Fisher DR, Shukitt-Hale B. Blueberry supplementation attenuates microglia activation and increases neuroplasticity in mice consuming a high fat diet. Nutr Neurosci. 2017 Sep:1–11. doi:10.1080/1028415X.2017.1376472.
- Meireles M, Marques C, Norberto S, Fernandes I, Mateus N, Rendeiro C, et al. The impact of chronic blackberry intake on the neuroinflammatory status of rats fed a standard or high-fat diet. J Nutr Biochem., 2015;26:1166–73.
- Batista Â, Soares E, Mendonça M, da Silva J, Dionísio A, Sartori C, et al. Jaboticaba berry peel intake prevents insulin resistance-induced tau phosphorylation in mice. Mol Nutr Food Res. 2017 Oct;61(10). doi:10.1002/mnfr.201600952.
- Park KS. Raspberry ketone, a naturally occurring phenolic compound, inhibits adipogenic and lipogenic gene expression in 3T3-L1 adipocytes. Pharm Biol. 2015 Jun;53(6):870–5. doi:10.3109/13880209.2014.946059.
- Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H. Anti-obese action of raspberry ketone. Life Sci. 2005 May;77(2):194–204.
- Wang L, Meng X, Zhang F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food. 2012 May;15(5):495–503. doi:10.1089/jmf.2011.1717.
- Jean-Gilles D, Li L, Ma H, Yuan T, Chichester CO, Seeram NP. Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen induced arthritis rat model. J Agric Food Chem. 2012;60(23):5755–62. doi:10.1021/jf203456w.
- Zhao L, Zou T, Gomez NA, Wang B, Zhu MJ, Du M. Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1. Nutr Diabetes. 2018 Jul;8(1):39. doi:10.1038/s41387-018-0049-6.
- Noratto GD, Chew BP, Atienza LM. Red raspberry (Rubus idaeus L.) intake decreases oxidative stress in obese diabetic (db/db) mice. Food Chem. 2017 Jul 15;227:305–14. doi:10.1016/j.foodchem.2017.01.097.
- Schell J, Betts NM, Lyons TJ, Basu A. Raspberries improve postprandial glucose and acute and chronic inflammation in adults with type 2 diabetes. Ann Nutr Metab. 2019;74(2):165–74. doi:10.1159/000497226.
- Amin MM, Arbid MS. Estimation of ellagic acid and/or repaglinide effects on insulin signaling, oxidative stress, and inflammatory mediators of liver, pancreas, adipose tissue, and brain in insulin resistant/type 2 diabetic rats. Appl Physiol Nutr Metab. 2017 Feb;42(2):181–92. doi:10.1139/apnm-2016-0429.
- Allam G, Mahdi EA, Alzahrani AM, Abuelsaad AS. Ellagic acid alleviates adjuvant induced arthritis by modulation of pro- and anti-inflammatory cytokines. Cent Eur J Immunol. 2016;4(4):339–49. doi:10.5114/ceji.2016.65132.
- Galli RL, Carey AN, Luskin KA, Bielinski DF, Shukitt-Hale B. Red raspberries can improve motor function in aged rats. J Berry Res 2016;6:97–103.
- Fortalezas S, Tavares L, Pimpão R, Tyagi M, Pontes V, Alves PM, et al., Antioxidant properties and neuroprotective capacity of strawberry tree fruit (Arbutus unedo). Nutrients. 2010;2(2):214–29. doi:10.3390/nu2020214.
- Meireles M, Rodríguez-Alcalá LM, Marques C, Norberto S, Freitas J, Fernandes I, et al. Effect of chronic consumption of blackberry extract on high-fat induced obesity in rats and its correlation with metabolic and brain outcomes. Food Funct. 2016 Jan;7(1):127–39. doi:10.1039/c5fo00925a.
- Bedel HA, Kencebay Manas C, Özbey G, Usta C. The antidepressant-like activity of ellagic acid and its effect on hippocampal brain derived neurotrophic factor levels in mouse depression models. Nat Prod Res. 2018 Dec;32(24):2932–5. doi:10.1080/14786419.2017.1385021.
- Leger M, Quiedeville A, Bouet V, Haelewyn B, Boulouard M, Schumann-Bard P, et al. Object recognition test in mice. Nat Protoc. 2013;8(12):2531–7. doi:10.1038/nprot.2013.155.
- Harrison FE, Reiserer RS, Tomarken AJ, McDonald MP. Spatial and nonspatial escape strategies in the Barnes maze. Learn Mem. 2006;13(6):809–19.
- Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, et al. A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease. PLoS One. 2013 Nov;8(11):e80355. doi:10.1371/journal.pone.0080355. eCollection 2013.
- Engin A. Eat and death: chronic over-eating. Adv Exp Med Biol. 2017;960:53–80. doi:10.1007/978-3-319-48382-5_3.
- Fu Z, Wu J, Nesil T, Li MD, Aylor KW, Liu Z. Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction. Am J Physiol Endocrinol Metab. 2017 Feb 1;312(2):E89–E97. doi:10.1152/ajpendo.00297.2016.
- Heyward FD, Walton RG, Carle MS, Coleman MA, Garvey WT, Sweatt JD. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression. Neurobiol Learn Mem. 2012 Jul;98(1):25–32. doi:10.1016/j.nlm.2012.04.005.
- McLean FH, Grant C, Morris AC, Horgan GW, Polanski AJ, Allan K, et al. Rapid and reversible impairment of episodic memory by a high-fat diet in mice. Sci Rep. 2018;8(1):11976. doi:10.1038/s41598-018-30265-4.
- Shah D, Verhoye M, Van der Linden A, D'Hooge R. Acquisition of spatial search strategies and reversal learning in the morris water maze depend on disparate brain functional connectivity in mice. Cereb Cortex. 2018. doi:10.1093/cercor/bhy329. [Epub ahead of print].
- Pooters T, Laeremans A, Gantois I, Vermaercke B, Arckens L, D'Hooge R. Comparison of the spatial-cognitive functions of dorsomedial striatum and anterior cingulate cortex in mice. PLoS One. 2017;12(5):e0176295. doi:10.1371/journal.pone.0176295. eCollection 2017.
- Wu H, Liu Q, Kalavagunta PK, Huang Q, Lv W, An X, et al. Normal diet vs high fat diet – a comparative study: behavioral and neuroimmunological changes in adolescent male mice. Metab Brain Dis. 2018;33(1):177–90. doi:10.1007/s11011-017-0140-z.
- Williams CM, El Mohsen MA, Vauzour D, Rendeiro C, Butler LT, Ellis JA, et al. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic Biol Med. 2008;45(3):295–305. doi:10.1016/j.freeradbiomed.2008.04.008.
- Liao H, Chou LM, Chien YW, Wu CH, Chang JS, Lin CI, et al. Grape powder consumption affects the expression of neurodegeneration-related brain proteins in rats chronically fed a high-fructose-high-fat diet. J Nutr Biochem. 2017 May;43:132–40. doi:10.1016/j.jnutbio.2017.02.013.
- Neshatdoust S, Saunders C, Castle SM, Vauzour D, Williams C, Butler L, et al. High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials. Nutr Healthy Aging. 2016;4(1):81–93. doi:10.3233/NHA-1615.
- Ávlos Y, Kerr B, Maliqueo M, Dorfman M. Cell and molecular mechanisms behind diet-induced hypothalamic inflammation and obesity. J Neuroendocrinol. 2018 Oct;30(10):e12598. doi:10.1111/jne.12598.
- Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9:46–56.
- Morita S, Miyata S. Different vascular permeability between the sensory and secretory circumventricular organs of adult mouse brain. Cell Tissue Res. 2012:349:589–603.
- Herrera AJ, Espinosa-Oliva AM, Oliva-Martin MJ, Carrillo-Jimenez A, Venero JL, de Pablos RM. Collateral damage: contribution of peripheral inflammation to neurodegenerative diseases. Curr Top Med Chem. 2015;15:2193–210.
- DeFuria J, Bennett G, Strissel KJ, Perfield JW, Milbury PE, Greenberg AS,, et al. Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. J Nutri. 2009;139:1510–6.
- Liu Y, Wang L, Luo M, Chen N, Deng X, He J, et al. Inhibition of PAI-1 attenuates perirenal fat inflammation and the associated nephropathy in high-fat diet-induced obese mice. Am J Physiol Endocrinol Metab. 2019;316(2):E260–E267. doi:10.1152/ajpendo.00387.2018.
- Azam S, Jakaria M, Kim IS, Kim J, Haque ME, Choi DK. Regulation of toll-like receptor (TLR) signaling pathway by polyphenols in the treatment of age-linked neurodegenerative diseases: focus on TLR4 signaling. Front Immunol. 2019;10:1000. doi:10.3389/fimmu.2019.01000. eCollection 2019.
- Spagnuolo C, Moccia S, Russo GL. Anti-inflammatory effects of flavonoids in neurodegenerative disorders. Eur J Med Chem. 2018;153:105–15.
- Park HK, Ahima RS. Leptin signaling. F1000Prime Rep. 2014 Sep;6:73. doi:10.12703/P6-73. eCollection 2014.
- Scarpace PJ, Zhang Y. Leptin resistance: a prediposing factor for diet-induced obesity. Am J Physiol Regul Integr Comp Physiol. 2009;296(3):R493–500. doi:10.1152/ajpregu.90669.2008.
- Barrientos C, Racotta R, Quevedo L. Glucosamine attenuates increases of intraabdominal fat, serum leptin levels, and insulin resistance induced by a high-fat diet in rats. Nutr Res. 2010;30(11):791–800.
- Meydani M, Hasan ST. Dietary polyphenols and obesity. Nutrients. 2010;2(7):737–51. doi:http://dx.doi.org.tcsedsystem.idm.oclc.org/10.3390/nu2070737.