Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 25, 2022 - Issue 9
1,131
Views
7
CrossRef citations to date
0
Altmetric
Articles

Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis

, ORCID Icon, , , , , & show all

References

  • Headache Classification Committee of The International Headache Society (IHS). The international classification of headache disorders, (beta version). Cephalalgia. 2013;33(9):629–808.
  • Sujan MU, Rao MR, Kisan R, Abhishekh HA. Influence of hydrotherapy on clinical and cardiac autonomic function in migraine patients. J Neurosci Rural Pract. 2016;7(1):109–13.
  • Menken M, Munsat TL, Toole JF. The global Burden of disease study. Arch Neurol. 2000;57(3):418–20.
  • Woldeamanuel YW, Cowan RP. Migraine affects 1 in 10 people worldwide featuring recent rise: a systematic review and meta-analysis of community-based studies involving 6 million participants. J Neurol Sci. 2017;372:307–15.
  • Woldeamanuel Y, Cowan R. (2016). Worldwide migraine epidemiology: systematic review and meta-analysis of 302 community-based studies involving 6,216,995 participants (P6. 100).
  • Leonardi M, Raggi A. Burden of migraine: international perspectives. Neurol Sci 2013;34(Suppl 1):S117–8.
  • Silberstein SD, Winner PK, Chmiel JJ. Migraine preventive medication reduces resource utilization. Headache: J Head Face Pain. 2003;43(3):171–8.
  • Silberstein SD, Feliu AL, Rupnow MF, Blount AC, Boccuzzi SJ. Topiramate in migraine prophylaxis: long-term impact on resource utilization and cost. Headache: J Head Face Pain. 2007;47(4):500–10.
  • Silberstein SD. Preventive migraine treatment. Continuum Lifelong Learn Neurol. 2015;21(4 Headache):973–89.
  • Mitsikostas DD, Rapoport AM. New players in the preventive treatment of migraine. BMC Med. 2015;13(1):279.
  • Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007;68(5):343–9.
  • Friedman MH, Peterson SJ, Behar CF, Zaidi Z. Intraoral chilling versus oral sumatriptan for acutemigraine. Heart Dis. 2001;3(6):357–61.
  • Wallace DC. Mitochondrial defects in neurodegenerative disease. Ment Retard Dev Disabil Res Rev. 2001;7(3):158–66.
  • Stuart S, Griffiths LR. A possible role for mitochondrial dysfunction in migraine. Mol Genet Genomics. 2012;287(11-12):837–44.
  • Colombo B, Saraceno L, Comi G. Riboflavin and migraine: the bridge over troubled mitochondria. Neurol Sci. 2014;35(1):141–4.
  • Moher D, Liberati A, Tetzlaff J, Altman DG, Prisma Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.
  • Namazi N, Heshmati J, Tarighat-Esfanjani A. Supplementation with Riboflavin (Vitamin B2) for migraine prophylaxis in adults and children: a review. Int J Vitam Nutr Res. 2015;85(1-2):79–87.
  • Rehman T, Ahmad S, Fatima Q. Effects of dietary supplementations and herbs on migraine - a systematic review. J Complement Integr Med. 2019;16(3):1–11.
  • Thompson D, Saluja H. Prophylaxis of migraine headaches with riboflavin: a systematic review. J Clin Pharm Ther. 2017;42(4):394–403.
  • Breen C, Crowe A, Roelfsema HJ, Saluja IS. High-dose riboflavin for prophylaxis of migraine. Can Fam Physician. 2003;49:1291–3.
  • Gaul C, Diener H-C, Danesch U. Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. J Headache Pain. 2015;16:516.
  • Maizels M, Blumenfeld A, Burchette R. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache. 2004;44(9):885–90.
  • Nambiar NJ, Aiyappa C, Srinivasa R. Oral riboflavin versus oral propranolol in migraine prophylaxis: an open label randomized controlled trial. Neurol Asia. 2011;16(3):223–229.
  • Rahimdel A, et al. Effectiveness of Vitamin B2 versus sodium valproate in migraine prophylaxis: a randomized clinical trial. Electron Physician. 2015;7(6):1344–8.
  • Sándor PS, Afra J, Ambrosini A, Schoenen J. Prophylactic treatment of migraine with β-blockers and riboflavin: differential effects on the intensity dependence of auditory evoked cortical potentials. Headache: J Head Face Pain. 2000;40(1):30–35.
  • Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology. 1998;50(2):466–70.
  • Schoenen J, Lenaerts M, Bastings E. High-dose riboflavin as a prophylactic treatment of migraine: results of an open pilot study. Cephalalgia. 1994;14(5):328–9.
  • Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhaupl KM, Arnold G. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol. 2004;11(7):475–7.
  • Blumenfeld H. Neuroanatomy through clinical cases. 2nd ed. pp. 139–41. Sunderland: Sinauer Associates; 2010.
  • Kristoffersen ES, Lundqvist C. Medication-overuse headache: epidemiology, diagnosis and treatment. Ther Adv Drug Saf. 2014;5(2):87–99.
  • Gorman GS, Chinnery PF, DiMauro S, Hirano M, Koga Y, McFarland R, et al. Mitochondrial diseases. Nat Rev Dis Primers. 2016;2(1):1–22.
  • Daniel O, Mauskop A. Nutraceuticals in acute and prophylactic treatment of migraine. Curr Treat Options Neurol. 2016;18(4):14.
  • Henriques B, Lucas GT, Gomes MC. Therapeutic approaches using riboflavin in mitochondrial energy metabolism disorders. Curr Drug Targets. 2016;17(13):1527–34.
  • The Cochrane Taiwan. Is Vitamin B2 effective in preventing migraine in adults? Evidence-based clinical practice guidelines for pain management. 2020: 30–31. Available from: https://taiwan.cochrane.org/news/%E5%AF%A6%E8%AD%89%E7%96%BC%E7%97%9B%E8%87%A8%E5%BA%8A%E7%85%A7%E8%AD%B7%E6%8C%87%E5%BC%95.
  • Bolay H, Ozge A, Saginc P, Orekici G, Uludüz D, Yalın O, et al. Gender influences headache characteristics with increasing age in migraine patients. Cephalalgia. 2015;35(9):792–800.
  • Victor TW, Hu X, Campbsell JC, Buse DC, Lipton RB. Migraine prevalence by age and sex in the United States: a life-span study. Cephalalgia. 2010;30(9):1065–72.
  • Dogan VB, Dagdeviren H, Dirican A, Dirican AC, Tutar NK, Yayla VA, Cengiz H. Hormonal effect on the relationship between migraine and female sexual dysfunction. Neurol Sci. 2017;38(9):1651–5.
  • Avona A, Burgos-Vega C, Burton MD, Akopian AN, Price TJ, Dussor G. Dural calcitonin gene-related peptide produces female-specific responses in rodent migraine models. J Neurosci. 2019;39(22):4323–31.
  • Vetvik KG, MacGregor EA. Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. Lancet Neurol. 2017;16(1):76–87.
  • Chong CD, Dumkrieger GM, Schwedt TJ. Structural co-variance patterns in migraine: A cross-sectional study exploring the role of the hippocampus. Headache: J Head Face Pain. 2017;57(10):1522–31.
  • Liu HY, Chou KH, Chen WT. Migraine and the hippocampus. Curr Pain Headache Rep. 2018;22(2):13.
  • Maleki N, Becerra L, Brawn J, McEwen B, Burstein R, Borsook D. Common hippocampal structural and functional changes in migraine. Brain Struct Funct. 2013;218(4):903–12.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.