Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 26, 2023 - Issue 5
530
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Astaxanthin delays brain aging in senescence-accelerated mouse prone 10: inducing autophagy as a potential mechanism

, , , , , , & show all

References

  • Seidler RD, Bernard JA, Burutolu TB, Fling BW, Gordon MT, Gwin JT, et al. Motor control and aging: links to age-related brain structural, functional, and biochemical effects. Neurosci Biobehav Rev. 2010;34(5):721–33.
  • Bettio LEB, Rajendran L, Gil-Mohapel J. The effects of aging in the hippocampus and cognitive decline. Neurosci Biobehav Rev. 2017;79:66–86.
  • Wu H, Niu H, Shao A, Wu C, Dixon BJ, Zhang J, et al. Astaxanthin as a potential neuroprotective agent for neurological diseases. Mar Drugs. 2015;13(9):5750–66.
  • Ambati RR, Phang SM, Ravi S, Aswathanarayana RG. Astaxanthin: sources, extraction, stability, biological activities and its commercial applications–a review. Mar Drugs. 2014;12(1):128–52.
  • Fu M, Zhang X, Zhang X, Yang L, Luo S, Liu H. Autophagy plays a role in the prolongation of the life span of Caenorhabditis elegans by astaxanthin. Rejuv Res. 2021;24(3):198–205.
  • Kim SH, Kim H. Astaxanthin modulation of signaling pathways that regulate autophagy. Mar Drugs. 2019;17(10):546.
  • He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet. 2009;43:67–93.
  • Luo L, Qin ZH. Autophagy, aging, and longevity. Adv Exp Med Biol. 2019;1206:509–25.
  • Tóth ML, Sigmond T, Borsos E, Barna J, Erdélyi P, Takács-Vellai K, et al. Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. Autophagy. 2008;4(3):330–8.
  • Renna M, Bento CF, Fleming A, Menzies FM, Siddiqi FH, Ravikumar B, et al. IGF-1 receptor antagonism inhibits autophagy. Hum Mol Genet. 2013;22(22):4528–44.
  • Donlon TA, Morris BJ, Chen R, Masaki KH, Allsopp RC, Willcox DC, et al. FOXO3 longevity interactome on chromosome 6. Aging Cell. 2017;16(5):1016–25.
  • Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, et al. The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun. 2013;4:2267.
  • Cao DJ, Jiang N, Blagg A, Johnstone JL, Gondalia R, Oh M, et al. Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy. J Am Heart Assoc. 2013;2(2):e000016.
  • Sengupta A, Molkentin JD, Yutzey KE. Foxo transcription factors promote autophagy in cardiomyocytes. J Biol Chem. 2009;284(41):28319–31.
  • Jia G, Cheng G, Gangahar DM, Agrawal DK. Insulin-like growth factor-1 and TNF-alpha regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells. Immunol Cell Biol. 2006;84(5):448–54.
  • Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet. 2004;36(6):585–95.
  • Kim DK, Kim TH, Lee SJ. Mechanisms of aging-related proteinopathies in Caenorhabditis elegans. Exp Mol Med. 2016;48(10):e263.
  • Jia K, Thomas C, Akbar M, Sun Q, Adams-Huet B, Gilpin C, et al. Autophagy genes protect against salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci USA. 2009;106(34):14564–9.
  • Unno K, Takagi Y, Konishi T, Suzuki M, Miyake A, Kurotaki T, et al. Mutation in sodium-glucose cotransporter 2 results in down-regulation of amyloid beta (A4) precursor-like protein 1 in young age, which may lead to poor memory retention in old age. Int J Mol Sci. 2020;21(15):5579.
  • Sztretye M, Singlár Z, Szabó L, Angyal Á, Balogh N, Vakilzadeh F, et al. Improved tetanic force and mitochondrial calcium homeostasis by Astaxanthin treatment in mouse skeletal muscle. Antioxidants. 2020;9(2):98.
  • EFSA NDA Panel (EFSA Panel on Dietetic Products NaA). Scientific opinion on the safety of astaxanthin-rich ingredients (AstaREAL A1010 and AstaREAL L10) as novel food ingredients. EFSA J. 2014;12(7):3757.
  • Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, et al. Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. Nature. 2018;558(7708):136–40.
  • Rubinsztein DC, Mariño G, Kroemer G. Autophagy and aging. Cell. 2011;146(5):682–95.
  • Fakhri S, Abbaszadeh F, Dargahi L, Jorjani M. Astaxanthin: A mechanistic review on its biological activities and health benefits. Pharmacol Res. 2018;136:1–20.
  • Shen M, Chen K, Lu J, Cheng P, Xu L, Dai W, et al. Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy. Mediat Inflamm. 2014;2014:954502.
  • Unno K, Takabayashi F, Yoshida H, Choba D, Fukutomi R, Kikunaga N, et al. Daily consumption of green tea catechin delays memory regression in aged mice. Biogerontology. 2007;8(2):89–95.
  • Lye TC, Piguet O, Grayson DA, Creasey H, Ridley LJ, Bennett HP, et al. Hippocampal size and memory function in the ninth and tenth decades of life: the Sydney Older Persons Study. J Neurol Neurosurg Psychiatry. 2004;75(4):548–54.
  • Aoi W, Maoka T, Abe R, Fujishita M, Tominaga K. Comparison of the effect of non-esterified and esterified astaxanthins on endurance performance in mice. J Clin Biochem Nutr. 2018;62(2):161–6.
  • Danka Mohammed CP, Park JS, Nam HG, Kim K. MicroRNAs in brain aging. Mech Ageing Dev. 2017;168:3–9.
  • Sorrenti V, Davinelli S, Scapagnini G, Willcox BJ, Allsopp RC, Willcox DC. Astaxanthin as a putative geroprotector: molecular basis and focus on brain aging. Mar Drugs. 2020;18(7):351.
  • Kramer AF, Erickson KI. Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function. Trends Cogn Sci. 2007;11(8):342–8.
  • Reuter-Lorenz PA, Park DC. How does it STAC up? revisiting the scaffolding theory of aging and cognition. Neuropsychol Rev. 2014;24(3):355–70.
  • Harada CN, Natelson Love MC, Triebel KL. Normal cognitive aging. Clin Geriatr Med. 2013;29(4):737–52.
  • Hwang SH, Kim JM, Kim S, Yoon MJ, Park KS. Chemical transformation of Astaxanthin from Haematococcus pluvialis improves Its antioxidative and anti-inflammatory activities. ACS Omega. 2020;5(30):19120–30.
  • Fukuta T, Hirai S, Yoshida T, Maoka T, Kogure K. Enhancement of antioxidative activity of astaxanthin by combination with an antioxidant capable of forming intermolecular interactions. Free Radical Res. 2020;54(11-12):818–28.
  • Kamezaki C, Nakashima A, Yamada A, Uenishi S, Ishibashi H, Shibuya N, et al. Synergistic antioxidative effect of astaxanthin and tocotrienol by co-encapsulated in liposomes. J Clin Biochem Nutr. 2016;59(2):100–6.
  • Liu N, Zeng L, Zhang YM, Pan W, Lai H. Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins. Neural Regen Res. 2021;16(6):1062–7.
  • Yazaki K, Yoshikoshi C, Oshiro S, Yanase S. Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans. Oxid Med Cell Longevity. 2011;2011:596240.
  • Wyss-Coray T. Ageing, neurodegeneration and brain rejuvenation. Nature. 2016;539(7628):180–6.
  • Wong SQ, Kumar AV, Mills J, Lapierre LR. Autophagy in aging and longevity. Hum Genet. 2020;139(3):277–90.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.