Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 26, 2023 - Issue 7
268
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Dietary flavonoids-rich Citrus reticulata peel extract interacts with CREB signaling to suppress seizures and linked neurobehavioral impairments in a kindling mouse model

, & ORCID Icon

References

  • Trinka E, Kwan P, Lee B, Dash A. Epilepsy in Asia: disease burden, management barriers, and challenges. Epilepsia. 2019;60:7–21.
  • Thijs RD, Surges R, O'Brien TJ, Sander JW. Epilepsy in adults. The Lancet. 2019;393:689–701.
  • Keezer MR, Sisodiya SM, Sander JW. Comorbidities of epilepsy: current concepts and future perspectives. The Lancet Neurol. 2016;15:106–15.
  • Ijff DM, Aldenkamp AP. Cognitive side-effects of antiepileptic drugs in children. Handb Clin Neurol. 2013;111:707–18.
  • Chen B, Choi H, Hirsch LJ, Katz A, Legge A, Buchsbaum R, Detyniecki K. Psychiatric and behavioral side effects of antiepileptic drugs in adults with epilepsy. Epilepsy Behav. 2017;76:24–31.
  • Babayigit A, Dirik E, Bober E, Cakmakcı H. Adverse effects of antiepileptic drugs on bone mineral density. Pediatr Neurol 2006;35:177–81.
  • Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016;5:1–15.
  • Mahmoud AM, Hernandez Bautista RJ, Sandhu MA, Hussein OE. Beneficial effects of citrus flavonoids on cardiovascular and metabolic health. Oxid Med Cell Longev. 2019;10:5484138.
  • Ortuno A, Benavente-Garcia O, Castillo J, Alcaraz M, Vicente V, Del Rio JA. Beneficial action of Citrus flavonoids on multiple cancer-related biological pathways. Curr Cancer Drug Targets. 2007;7:795–809.
  • Aneja S, Sharma S. Newer anti-epileptic drugs. Indian Pediatr. 2013;50:1033–40.
  • Diniz TC, Silva JC, Lima-Saraiva SR, Ribeiro FP, Pacheco AG, de Freitas RM, et al. The role of flavonoids on oxidative stress in epilepsy. Oxid Med Cell Longev. 2015;11:2015.
  • Costa MTH, Santos De Melo CH, Fonseca De Carvalho RB, Costa LM, De Souza AA, David JM, et al. Phytochemical profile and qualification of biological activity of an isolated fraction of bellis perennis. Biol Res. 2013;46:231–8.
  • Ferreira A, Rodrigues M, Fortuna A, Falcão A, Alves G. Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: an in vitro evaluation with focus on antiepileptic drugs. Food Res Int. 2018;103:110–20.
  • Andriani F, Salsabila T, Nabilah B, Kumaidah E, Hardian GA. The effect of citrus peel extract (Citrus reticulata) on hippocampal histopathological appearance in wistar rats induced by trimethyltin chloride. Malays J Med Health Sci. 2020;16:39–43.
  • Mazumder AG, Sharma P, Patial V, Singh D. Crocin attenuates kindling development and associated cognitive impairments in mice via inhibiting reactive oxygen species-mediated NF-κB activation. Basic Clin Pharmacol Toxicol. 2017;120:426–33.
  • Chatzikonstantinou A. Epilepsy and the hippocampus. Front Neurol Neurosci Basel, Karger. 2014;34:121–42.
  • Safdar MN, Kausar T, Jabbar S, Mumtaz A, Ahad K, Saddozai AA. Extraction and quantification of polyphenols from kinnow (Citrus reticulate L.) peel using ultrasound and maceration techniques. J Food Drug Anal. 2017;25:488–500.
  • Singh D, Mishra A, Goel RK. Effect of saponin fraction from Ficus religiosa on memory deficit, and behavioral and biochemical impairments in pentylenetetrazol kindled mice. Epilepsy Behav. 2013;27:206–11.
  • Sharma P, Sharma S, Singh D. Apigenin reverses behavioural impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus. Nutr Neurosci. 2020;23:118–27.
  • Kumari S, Sharma P, Mazumder AG, Rana AK, Sharma S, Singh D. Development and validation of chemical kindling in adult zebrafish: a simple and improved chronic model for screening of antiepileptic agents. J Neurosci Methods. 2020;346(108916). https://pubmed.ncbi.nlm.nih.gov/32818549/
  • Sharma P, Kumari S, Sharma J, Purohit R, Singh D. Hesperidin interacts with CREB-BDNF signaling pathway to suppress pentylenetetrazole-induced convulsions in zebrafish. Front Pharmacol. 2021;11:2178.
  • Park H, Poo MM. Neurotrophin regulation of neural circuit development and function. Nat Rev Neurosci. 2013;14:7–23.
  • Gómez-Palacio-Schjetnan A, Escobar ML. Neurotrophins and synaptic plasticity. Curr Top Behav Neurosci. 2013;15:117–36.
  • Mortazavi F, Ericson M, Story D, Hulce VD, Dunbar GL. Spatial learning deficits and emotional impairments in pentylenetetrazole-kindled rats. Epilepsy Behav. 2005;7:629–38.
  • Kawahata I, Yoshida M, Sun W, Nakajima A, Lai Y, Osaka N, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signalling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm. 2013;120:1397–409.
  • Rendeiro C, Spencer JP, Vauzour D, Butler LT, Ellis JA, Williams CM. The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms. Genes Nutr. 2009;4:251–70.
  • Ko YH, Kim SK, Lee SY, Jang CG. Flavonoids as therapeutic candidates for emotional disorders such as anxiety and depression. Arch Pharm Res. 2020;43:1128–43.
  • Germán-Ponciano LJ, Puga-Olguín A, De Jesús Rovirosa-Hernández M, Caba M, Meza E, Rodríguez-Landa JF. Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats. Acta Pharmaceutica. 2020;70:387–97.
  • Angelucci F, Brene S, Mathe AA. BDNF in schizophrenia, depression and corresponding animal models. Mol Psychiatry. 2005;10:345–52.
  • Zapata-Sudo G, Mendes TC, Kartnaller MA, Fortes TO, Freitas NF, Kaplan MA, et al. Sedative and anticonvulsant activities of methanol extract of Dorste niaarifolia in mice. J Ethnopharmacol. 2010;130:9–12.
  • Maciejak P, Lehner M, Turzyńska D, Szyndler J, Bidziński A, Taracha E, et al. The opposite role of hippocampal mGluR1 in fear conditioning in kindled and non-kindled rats. Brain Res. 2008;1187:184–93.
  • Miranda M, Morici JF, Zanoni MB, Bekinschtein P. Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain. Front Cell Neurosci. 2019;363(13).
  • Nagahara AH, Tuszynski MH. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov. 2011;10:209–19.
  • Ahmed MA, Kamel EO. Involvement of H2S, NO and BDNF-TrkB signalling pathway in the protective effects of simvastatin against pentylenetetrazole-induced kindling and cognitive impairments in mice. Basic Clin. Pharmacol Toxicol. 2020;127:461–76.
  • Demir M, Akarsu EO, Dede HO, Bebek N, Yıldız SO, Baykan B, Akkan AG. Investigation of the roles of new antiepileptic drugs and serum BDNF levels in efficacy and safety monitoring and quality of life: a clinical research. Curr Clin Pharmacol. 2020;15:49–63.
  • Vogel C, Marcotte EM. Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat Rev Genet. 2012;13:227–32.
  • Maier T, Guell M, Serrano L. Correlation of mRNA and protein in complex biological samples. FEBS Lett. 2009;583:3966–73.
  • Schwanhäusser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J, et al. Global quantification of mammalian gene expression control. Nature. 2011;473:337–42.
  • Sharova LV, Sharov AA, Nedorezov T, Piao Y, Shaik N, Ko MS. Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells. DNA Res. 2009;16:45–58.
  • Yen HC, Xu Q, Chou DM, Zhao Z, Elledge SJ. Global protein stability profiling in mammalian cells. Science. 2008;322:918–23.
  • Brigadski T, Leßmann V. The physiology of regulated BDNF release. Cell Tissue Res. 2020;18:1–31.
  • Humpel C, Wetmore C, Olson L. Regulation of brain-derived neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol-induced epileptic seizures. Neuroscience. 1993;53:909–18.
  • Çelik H, Kandemir FM, Caglayan C, Özdemir S, Çomaklı S, Kucukler S, et al. Neuroprotective effect of rutin against colistin-induced oxidative stress, inflammation and apoptosis in rat brain associated with the CREB/BDNF expressions. Mol Bio Reports. 2020;47:2023–34.
  • Sharma P, Kumar A, Singh D. Dietary flavonoids interaction with CREB-BDNF pathway: an unconventional approach for comprehensive management of epilepsy. Curr Neuropharmacol. 2019;17:1158–75.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.