Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 26, 2023 - Issue 8
5,858
Views
1
CrossRef citations to date
0
Altmetric
Review

The influence of the macular carotenoids on women’s eye and brain health

&

References

  • Wu J, Zhou J, Tang X, Yu X, Shentu X. Association of sex with the global burden of age-related macular degeneration. Research Square. 2020;1:1–15.
  • GBD 2019 Dementia Forecasting Collaborators. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health. 2022;7(2):e105–e125.
  • Ou Z, Pan J, Tang S, Duan D, Yu D, Nong H, Wang Z. Global trends in the incidence, prevalence, and years lived with disability of Parkinson’s disease in 204 countries/territories from 1990 to 2019. Front Public Health. 1994;2021:1–16.
  • Voskuhl RR, Patel K, Paul F, Gold SM, Scheel M, Kuchling J, … MacKenzie-Graham A. Sex differences in brain atrophy in multiple sclerosis. Biol Sex Differ. 2020;11(1):1–10.
  • Lou L, Ye X, Xu P, et al. Association of sex with the global burden of cataract. JAMA Ophthalmol. 2018;136(2):116–121.
  • Zamani M, Zamani V, Heidari B, Parsian H, Esmaeilnejad-Ganji SM. Prevalence of osteoporosis with the world health organization diagnostic criteria in the eastern mediterranean region: a systematic review and meta-analysis. Arch Osteoporos. 2018;13(1):1–10.
  • Thornton J. WHO report shows that women outlive men worldwide. BMJ: British Medical Journal (Online). 2019;365:1.
  • Bots SH, Peters SA, Woodward M. Sex differences in coronary heart disease and stroke mortality: a global assessment of the effect of ageing between 1980 and 2010. BMJ Global Health. 2017;2(2):1–8.
  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249.
  • Austad SN, Fischer KE. Sex differences in lifespan. Cell Metab. 2016;23(6):1022–1033.
  • Andreeva M, Dukhonov D. About mortality data for Iceland. Human Mortality Database. 2008: 1–10.
  • Kraemer S. The fragile male. BMJ (Clinical Research ed.). 2000;321(7276):1609–1612.
  • Zarulli V, Kashnitsky I, Vaupel JW. Death rates at specific life stages mold the sex gap in life expectancy. Proc Natl Acad Sci USA. 2021;118(20):1–4.
  • Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol. 1997;84(3):223–243.
  • Klein S, Flanagan K. Sex differences in immune responses. Nat Rev Immunol. 2016;16:626–638.
  • Chamekh M, Casimir G. Editorial: sexual dimorphism of the immune inflammatory response in infectious and non-infectious diseases. Front Immunol. 2019;10:1–2.
  • Metcalf CJ, Roth O, Graham AL. Why leveraging sex differences in immune trade-offs may illuminate the evolution of senescence. Funct Ecol. 2020;34(1):129–40.
  • Tenkorang MA, Snyder B, Cunningham RL. Sex-related differences in oxidative stress and neurodegeneration. Steroids. 2018;133:21–27.
  • German A, Hochberg ZE. Sexual dimorphism of size ontogeny and life history. Front Pediatr. 2020;8:1–8.
  • Bethlehem RA, Seidlitz J, White SR, Vogel JW, Anderson KM, Adamson C, et al. Brain charts for the human lifespan. Nature. 2022;604:525–533.
  • Wiersch L, Weis S. Sex differences in the brain: more than just male or female. Cogn Neurosci. 2021;12(3-4):187–8.
  • Eliot L, Ahmed A, Khan H, Patel J. Dump the “dimorphism”: comprehensive synthesis of human brain studies reveals few male-female differences beyond size. Neurosci Biobehav Rev. 2021;125:667–97.
  • Spets DS, Slotnick SD. Are there sex differences in brain activity during long-term memory? A systematic review and fMRI activation likelihood estimation meta-analysis. Cogn Neurosci. 2021 Oct 2;12(3-4):163–73.
  • Gillies GE, Pienaar IS, Vohra S, Qamhawi Z. Sex differences in Parkinson’s disease. Front Neuroendocrinol. 2014;35(3):370–384.
  • Nichols E, Szoeke CE, Vollset SE, Abbasi N, Abd-Allah F, Abdela J, … Murray CJ. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology. 2019;18(1):88–106.
  • Hua X, Hibar DP, Lee S, et al. Sex and age differences in atrophic rates: An ADNI study with n = 1368 MRI scans. Neurobiol Aging. 2010;31:1463–1480.
  • Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. Age-related macular degeneration (AMD): Alzheimer's disease in the eye? J Alzheimer's Dis. 2011;24(4):615–631.
  • Li N, Wu X, Zhuang W, Xia L, Chen Y, Wang Y, … Zhou Y. Green leafy vegetable and lutein intake and multiple health outcomes. Food Chem. 2021;360:1–7.
  • Hajizadeh-Sharafabad F, Zahabi ES, Malekahmadi M, Zarrin R, Alizadeh M. Carotenoids supplementation and inflammation: a systematic review and meta-analysis of randomized clinical trials. Crit Rev Food Sci Nutr. 2021: 1–17.
  • Tan BL, Norhaizan ME. Carotenoids: How effective are they to prevent age-related diseases? Molecules. 2019;24(9):1–23.
  • Riggs BL, Melton III LJ, Robb RA, Camp JJ, Atkinson EJ, McDaniel L, … Khosla S. A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. J Bone Miner Res. 2008;23(2):205–214.
  • Wilson LA, De Groote I, Humphrey LT. Sex differences in the patterning of age-related bone loss in the human hallucal metatarsal in rural and urban populations. Am J Phys Anthropol. 2020;171(4):628–644.
  • Zia-Ul-Haq M, Riaz M, Modhi AO. Carotenoids and bone health. Carotenoids: Structure and Function in the Human Body. 2021;697–714.
  • Walallawita US, Wolber FM, Ziv-Gal A, Kruger MC, Heyes JA. Potential role of lycopene in the prevention of postmenopausal bone loss: evidence from molecular to clinical studies. Int J Mol Sci. 2020;21(19):1–21.
  • Charkos TG, Oumer KS. A Bayesian meta-analysis on the Association between beta-carotene and bone Mineral density. Annals of Data Science. 2022;9:315–3325.
  • Valenti MT, Perduca M, Romanelli MG, Mottes M, Dalle Carbonare L. A potential role for astaxanthin in the treatment of bone diseases. Mol Med Rep. 2020;22(3):1695–1701.
  • Bovier ER, Hammond BR. The macular carotenoids lutein and zeaxanthin are related to increased bone density in young healthy adults. Foods. 2017;6(9):78–83.
  • Sample PA, Quirante JS, Weinreb RN. Age-related changes in the human lens. Acta Ophthalmol. 1991;69:310–314.
  • Aslam TM, Haider D, Murray IJ. Principles of disability glare measurement: an ophthalmological perspective. Acta Ophthalmol Scand. 2007;85(4):354–360.
  • Hammond Jr BR, Wooten BR, Snodderly DM. Density of the human crystalline lens is related to the macular pigment carotenoids, lutein and zeaxanthin. Optometry and Vision Science: Official Publication of the American Academy of Optometry. 1997;74(7):499–504.
  • Chasan-Taber L, Willett WC, Seddon JM, Stampfer MJ, Rosner B, Colditz GA, … Hankinson SE. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr. 1999;70(4):509–516.
  • Hammond BR, Johnson BA, George ER. Oxidative photodegradation of ocular tissues: beneficial effects of filtering and exogenous antioxidants. Exp Eye Res. 2014;129:135–150.
  • Wooten BR, Hammond BR. Macular pigment: influences on visual acuity and visibility. Prog Retinal Eye Res. 2002;21(2):225–240.
  • Stringham JM, Fuld K, Wenzel AJ. Action spectrum for photophobia. JOSA A. 2003;20(10):1852–1858.
  • Flannagan MJ, Sivak M, Ensing M, Simmons CJ. Effect of wavelength on discomfort glare from monochromatic sources. University of Michigan, Ann Arbor, Transportation Research Institute, Ann Arbor, Michigan; 1989.
  • Stringham JM, Bovier ER, Wong JC, Hammond Jr BR. The influence of dietary lutein and zeaxanthin on visual performance. J Food Sci. 2010 Jan;75(1):R24–9.
  • Liu R, Wang T, Zhang B, Qin L, Wu C, Li Q, Ma L. Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. Invest Ophthalmol Visual Sci. 2015;56(1):252–258.
  • Akuffo KO, Nolan JM, Peto T, Stack J, Leung I, Corcoran L, Beatty S. Relationship between macular pigment and visual function in subjects with early age-related macular degeneration. Br J Ophthalmol. 2017;101(2):190–197.
  • Chang CY, Ke DS, Chen JY. Essential fatty acids and human brain. Acta Neurol Taiwan. 2009;18(4):231–41.
  • Joseph JA, Shukitt-Hale B, Casadesus GEMMA, Fisher D. Oxidative stress and inflammation in brain aging: nutritional considerations. Neurochem Res. 2005;30(6):927–935.
  • Erdman JW, Smith JW, Kuchan MJ, Mohn ES, Johnson EJ, Rubakhin SS, … Neuringer M. Lutein and brain function. Foods. 2015;4(4):547–564.
  • Lieblein-Boff JC, Johnson EJ, Kennedy AD, Lai CS, Kuchan MJ. Exploratory metabolomic analyses reveal compounds correlated with lutein concentration in frontal cortex, hippocampus, and occipital cortex of human infant brain. PloS one. 2015;10(8):1–19.
  • Wang W, Shinto L, Connor WE, Quinn JF. Nutritional biomarkers in Alzheimer's disease: the association between carotenoids, n-3 fatty acids, and dementia severity. J Alzheimer's Dis. 2008;13(1):31–38.
  • Min JY, Min KB. Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer's disease mortality in older adults. Dement Geriatr Cogn Disord. 2014;37(3-4):246–256.
  • Feart C, Letenneur L, Helmer C, Samieri C, Schalch W, Etheve S, … Barberger-Gateau P. Plasma carotenoids are inversely associated with dementia risk in an elderly French cohort. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2016;71(5):683–688.
  • Patel C, Patel P, Sarkar D, Bulsara J, Soni A, Isapure K, Acharya S. Neuroprotective effect of lutein in scopolamine-induced Alzheimer’s disease in mice and zebrafish. Revista Brasileira de Farmacognosia. 2021;31(6):762–771.
  • Yuan C, Chen H, Wang Y, Schneider JA, Willett WC, Morris MC. Dietary carotenoids related to risk of incident Alzheimer dementia (AD) and brain AD neuropathology: a community-based cohort of older adults. Am J Clin Nutr. 2021;113(1):200–208.
  • Bovier ER, Renzi LM, Hammond BR. A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency. PloS one. 2014;9(9):1–6.
  • Christensen K, Gleason CE, Mares JA. Dietary carotenoids and cognitive function among US adults, NHANES 2011–2014. Nutr Neurosci. 2020;23(7):554–562.
  • Nouchi R, Suiko T, Kimura E, Takenaka H, Murakoshi M, Uchiyama A, … Kawashima R. Effects of lutein and astaxanthin intake on the improvement of cognitive functions among healthy adults: a systematic review of randomized controlled trials. Nutrients. 2020;12(3):1–24.
  • Yagi A, Nouchi R, Butler L, Kawashima R. Lutein Has a positive impact on brain health in healthy older adults: A systematic review of randomized controlled trials and cohort studies. Nutrients. 2021;13(6):1–11.
  • Sheng LT, Jiang YW, Feng L, Pan A, Koh WP. Dietary total antioxidant capacity and late-life cognitive impairment: the Singapore Chinese health study. The Journals of Gerontology: Series A. 2021;77:561–569.
  • Gauci S, Young LM, Macpherson H, White DJ, Benson S, Pipingas A, Scholey A. Mediterranean diet and its components: potential to optimize cognition across the lifespan. Nutraceuticals in Brain Health and Beyond. Academic Press, London UK; 2021. 293-306.
  • Barnett SM, Khan NA, Walk AM, Raine LB, Moulton C, Cohen NJ, … Hillman CH. Macular pigment optical density is positively associated with academic performance among preadolescent children. Nutr Neurosci. 2018;21(9):632–640.
  • Renzi-Hammond LM, Bovier ER, Fletcher LM, Miller LS, Mewborn CM, Lindbergh CA, … Hammond BR. Effects of a lutein and zeaxanthin intervention on cognitive function: a randomized, double-masked, placebo-controlled trial of younger healthy adults. Nutrients. 2017;9(11):1–13.
  • Hammond Jr BR, Miller LS, Bello MO, Lindbergh CA, Mewborn C, Renzi-Hammond LM. Effects of lutein/zeaxanthin supplementation on the cognitive function of community dwelling older adults: a randomized, double-masked, placebo-controlled trial. Front Aging Neurosci. 2017;9:1–9.
  • Renzi LM, Dengler MJ, Puente A, Miller LS, Hammond Jr BR. Relationships between macular pigment optical density and cognitive function in unimpaired and mildly cognitively impaired older adults. Neurobiol Aging. 2014;35(7):1695–1699.
  • Hammond Jr BR, Curran-Celentano J, Judd S, Fuld K, Krinsky NI, Wooten BR, Snodderly DM. Sex differences in macular pigment optical density:: relation to plasma carotenoid concentrations and dietary patterns. Vision Res. 1996;36(13):2001–2012.
  • Delori FC, Goger DG, Keilhauer C, Salvetti P, Staurenghi G. Bimodal spatial distribution of macular pigment: evidence of a gender relationship. JOSA A. 2006;23(3):521–538.
  • Yu J, Johnson EJ, Shang F, Lim A, Zhou H, Cui L, … Liu N. Measurement of macular pigment optical density in a healthy Chinese population sample. Invest Ophthalmol Visual Sci. 2012;53(4):2106–2111.
  • Olmedilla-Alonso B, Beltrán-de-Miguel B, Estévez-Santiago R, Cuadrado-Vives C. Markers of lutein and zeaxanthin status in two age groups of men and women: dietary intake, serum concentrations, lipid profile and macular pigment optical density. Nutr J. 2014;13(1):1–11.
  • Johnson EJ, Maras JE, Rasmussen HM, Tucker KL. Intake of lutein and zeaxanthin differ with age, sex, and ethnicity. J Am Diet Assoc. 2010;110(9):1357–1362.
  • Allore T, Lemieux S, Vohl MC, Couture P, Lamarche B, Couillard C. Correlates of the difference in plasma carotenoid concentrations between men and women. Br J Nutr. 2019;121(2):172–181.
  • Deurenberg P, Yap M, Van Staveren WA. Body mass index and percent body fat: a meta analysis among different ethnic groups. Int J Obes. 1998;22(12):1164–1171.
  • Johnson EJ, Hammond BR, Yeum KJ, Qin J, Wang XD, Castaneda C, … Russell RM. Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. Am J Clin Nutr. 2000;71(6):1555–1562.
  • Olson VA, Owens IP. Costly sexual signals: are carotenoids rare, risky or required? Trends Ecol Evol. 1998;13(12):510–514.
  • Forman MR, Beecher GR, Muesing R, Lanza E, Olson B, Campbell WS, … Graubard BI. The fluctuation of plasma carotenoid concentrations by phase of the menstrual cycle: a controlled diet study. Am J Clin Nutr. 1996;64(4):559–565.
  • Colucci M, Cammarata S, Assini A, Croce R, Clerici F, Novello C, … Tanganelli P. The number of pregnancies is a risk factor for Alzheimer's disease. Eur J Neurol. 2006;13(12):1374–1377.
  • Hammond BR. The dietary carotenoids lutein and zeaxanthin in pre-and- postnatal development. Functional Food Reviews. 2012;4(3):130–137.
  • Sasano H, Obana A, Sharifzadeh M, Bernstein PS, Okazaki S, Gohto Y, et al. Optical detection of macular pigment formation in premature infants. Transl Vis Sci Technol. 2018;7(4):1–10.
  • Vishwanathan, R., Kuchan, M.J., Sens, S., Johnson, E.J. Lutein and preterm infants with decreased concentrations of brain carotenoids. J Pediatr Gastroenterol Nutr. 2014;59:659–65.
  • Lai JS, Veetil VO, Lanca C, Lee BL, Godfrey KM, Gluckman PD, … Chong MF. Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age: the GUSTO study. Nutrients. 2020;12(2):1–11.
  • Landreneau JR, Hesemann NP, Cardonell MA. Review on the Myopia pandemic: epidemiology, risk factors, and prevention. Mo Med. 2021;118(2):156–163.
  • Hammond Jr BR. Possible role for dietary lutein and zeaxanthin in visual development. Nutr Rev. 2008;66(12):695–702.
  • Leung IYF, Sandstrom MM, Zucker CL, Neuringer M, Snodderly DM. Nutritional manipulation of primate retinas, II: effects of age, n–3 fatty acids, lutein, and zeaxanthin on retinal pigment epithelium. Invest Ophthalmol Visual Sci. 2004;45(9):3244–3256.
  • Rubin LP, Chan GM, Barrett-Reis BM, Fulton AB, Hansen RM, Ashmeade TL, … Adamkin DH. Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants. J Perinatol. 2012;32(6):418–424.
  • Costa S, Giannantonio C, Romagnoli C, Vento G, Gervasoni J, Persichilli S, … Cota F. Effects of lutein supplementation on biological antioxidant status in preterm infants: a randomized clinical trial. J Matern Fetal Neonatal Med. 2013;26(13):1311–1315.
  • Picone S, Ritieni A, Fabiano A, Graziani G, Paolillo P, Livolti G, … Gazzolo D. Lutein levels in arterial cord blood correlate with neuroprotein activin A in healthy preterm and term newborns: A trophic role for lutein? Clin Biochem. 2018;52:80–84.
  • Cota F, Costa S, Giannantonio C, Purcaro V, Catenazzi P, Vento G. Lutein supplementation and retinopathy of prematurity: a meta-analysis. J Matern Fetal Neonatal Med. 2022;35(1):175–80.
  • Gazzolo D, Picone S, Gaiero A, Bellettato M, Montrone G, Riccobene F, … Pellegrini G. Early pediatric benefit of lutein for maturing eyes and brain—an overview. Nutrients. 2021;13(9):1–26.
  • Bernstein PS, Ranganathan A. The emerging roles of the macular pigment carotenoids throughout the lifespan and in prenatal supplementation. J Lipid Res. 2021;62:1–10.
  • Bettler J, Zimmer JP, Neuringer M, DeRusso PA. Serum lutein concentrations in healthy term infants fed human milk or infant formula with lutein. Eur J Nutr. 2010;49(1):45–51.
  • Terlikowska KM, Dobrzycka B, Kinalski M, Terlikowski SJ. Serum concentrations of carotenoids and fat-soluble vitamins in relation to nutritional status of patients with ovarian cancer. Nutr Cancer. 2021;73(8):1480–1488.
  • Peng C, Gao C, Lu D, Rosner BA, Zeleznik O, Hankinson SE, … Tamimi RM. Circulating carotenoids and breast cancer among high-risk individuals. Am J Clin Nutr. 2021;113(3):525–533.
  • Sahni S, Dufour AB, Fielding RA, Newman AB, Kiel DP, Hannan MT, Jacques PF. Total carotenoid intake is associated with reduced loss of grip strength and gait speed over time in adults: The framingham offspring study. Am J Clin Nutr. 2021;113(2):437–445.
  • Palombo P, Fabrizi G, Ruocco V, Ruocco E, Flühr J, Roberts R, Morganti P. Beneficial long-term effects of combined oral/topical antioxidant treatment with carotenoids lutein and zeaxanthin on human skin: A double-blinded, placebo-controlled study in humans. J Skin Pharmacol and Physiol. 2007;20:199–210.
  • Głąbska D, Guzek D, Zakrzewska P, Lech G. Intake of lutein and zeaxanthin as a Possible factor influencing gastrointestinal symptoms in Caucasian individuals with ulcerative colitis in remission phase. J Clin Med. 2019;8(1):1–16.
  • Cerna J, Anaraki NSA, Robbs CM, Adamson BC, Flemming IR, Erdman JW, … Khan NA. Macular xanthophylls and markers of the anterior visual pathway among persons with multiple sclerosis. J Nutr. 2021;26:80–88.
  • Vishwanathan R, Kuchan MJ, Sen S, Johnson EJ. Lutein and preterm infants with decreased concentrations of brain carotenoids. J Pediatr Gastroenterol Nutr. 2014;59(5):659–665.