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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 27, 2024 - Issue 3
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Research Article

Triheptanoin, an odd-medium-chain triglyceride, impacts brain cognitive function in young and aged mice

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References

  • Wyss-Coray T. Ageing, neurodegeneration and brain rejuvenation. Nature. 2016;539:180–6. Available from: http://www.nature.com/articles/nature20411
  • Cunnane SC, Trushina E, Morland C, Prigione A, Casadesus G, Andrews ZB, et al. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov. 2020;19:609–33.
  • Castellano CA, Nugent S, Paquet N, Tremblay S, Bocti C, Lacombe G, et al. Lower brain 18F-fluorodeoxyglucose uptake but normal 11C-acetoacetate metabolism in mild Alzheimer’s disease dementia. J Alzheimer’s Dis. 2014;43:1343–53.
  • Cunnane SC, Courchesne-Loyer A, Vandenberghe C, St-Pierre V, Fortier M, Hennebelle M, et al. Can ketones help rescue brain fuel supply in later life? implications for cognitive health during aging and the treatment of Alzheimer’s disease. Front Mol Neurosci. 2016;9:1–21.
  • Li XY, Men WW, Zhu H, Lei J-F, Zuo F-X, Wang Z-J, et al. Age- and brain region- specific changes of glucose metabolic disorder, learning, and memory dysfunction in early Alzheimer’s disease assessed in APP/PS1 transgenic mice using 18F-FDG-PET. Int J Mol Sci. 2016;17:1–15.
  • Nugent S, Tremblay S, Chen KW, et al. Brain glucose and acetoacetate metabolism: a comparison of young and older adults. Neurobiol Aging. 2014;35:1386–95. doi:10.1016/j.neurobiolaging.2013.11.027
  • Taylor MK, Sullivan DK, Mahnken JD, Burns JM, Swerdlow RH. Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer’s disease. Alzheimer’s Dement Transl Res Clin Interv. 2018;4:28–36. doi:10.1016/j.trci.2017.11.002
  • Rusek M, Pluta R, Ułamek-Kozioł M, Czuczwar S J. Ketogenic diet in Alzheimer’s disease. Int J Mol Sci. 2019;20:3892. Available from: https://www.mdpi.com/1422-0067/20/16/3892
  • Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng C-P, et al. Ketogenic diet reduces midlife mortality and improves memory in aging mice. Cell Metab. 2017;26:547–57.e8. doi:10.1016/j.cmet.2017.08.004
  • Irfannuddin I, Sarahdeaz SFP, Murti K, Santoso B, Koibuchi N. The effect of ketogenic diets on neurogenesis and apoptosis in the dentate gyrus of the male rat hippocampus. J Physiol Sci. 2021;71. doi:10.1186/s12576-020-00786-7
  • Marin-Valencia I, Good LB, Ma Q, Malloy CR, Pascual JM. Heptanoate as a neural fuel: energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain. J Cereb Blood Flow Metab. 2013;33:175–82. doi:10.1038/jcbfm.2012.151
  • Szutowicz A, Bielarczyk H, Jankowska-Kulawy A, Pawełczyk T, Ronowska A. Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases. Neurochem Res. 2013;38(8):1523–42. doi:10.1007/s11064-013-1060-x
  • Kass HR, Winesett SP, Bessone SK, Turner Z, Kossoff EH. Use of dietary therapies amongst patients with GLUT1 deficiency syndrome. Seizure. 2016;35:83–7. doi:10.1016/j.seizure.2016.01.011
  • Xiaodong Y, Wang L, Tandon N, Sun H, Tian J, Du H, et al. Triheptanoin mitigates brain ATP depletion and mitochondrial dysfunction in a mouse model of Alzheimer’s disease. J Alzheimers Dis. 2020;78(1):425–37.
  • de Almeida Rabello Oliveira M, da Rocha Ataíde T, de Oliveira SL, de Melo Lucena AL, de Lira CEPR, Soares AA, et al. Effects of short-term and long-term treatment with medium- and long-chain triglycerides ketogenic diet on cortical spreading depression in young rats. Neurosci Lett. 2008;434:66–70.
  • Ghafouri S, Fathollahi Y, Javan M, Shojaei A, Asgari A, Mirnajafi-Zadeh J. Effect of low frequency stimulation on impaired spontaneous alternation behavior of kindled rats in Y-maze test. Epilepsy Res. 2016;126:37–44. doi:10.1016/j.eplepsyres.2016.06.010
  • Ellman GL, Courtney KD, Andres V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7:88–95. Available from: https://linkinghub.elsevier.com/retrieve/pii/0006295261901459
  • Namimatsu S, Ghazizadeh M, Sugisaki Y. Reversing the effects of formalin fixation with Citraconic Anhydride and heat: a universal antigen retrieval method. J Histochem Cytochem. 2005;53:3–11.
  • Hernandez AR, Hernandez CM, Campos KT, Truckenbrod LM, Sakarya Y, McQuail JA, et al. The antiepileptic ketogenic diet alters hippocampal transporter levels and reduces adiposity in aged rats. J Gerontol - Ser A Biol Sci Med Sci. 2018;73:450–8.
  • Roe CR, Sweetman L, Roe DS, David F, Brunengraber H. Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest. 2002;110:259–69.
  • Tefera TW, Tan KN, McDonald TS, Borges K. Alternative fuels in epilepsy and amyotrophic lateral sclerosis. Neurochem Res. 2017;42:1610–20.
  • Kraeuter AK, Guest PC, Sarnyai Z. The Y-maze for assessment of spatial working and reference memory in mice. Methods Mol Biol. 2019;1916:105–11.
  • Huang, J. et al. The effect of ketogenic diet on behaviors and synaptic functions of naive mice. Brain Behav. 2019;9(4):1–12.
  • McDonald T, Hodson MP, Bederman I, Puchowicz M, Borges K. Triheptanoin alters [U-13C6]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model. J Cereb Blood Flow Metab. 2020;40:678–91. doi:10.1177/0271678X19837380
  • Ullrich C, Pirchl M, Humpel C. Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits. Mol Cell Neurosci. 2010;45:408–17. doi:10.1016/j.mcn.2010.08.001
  • Paul R, Borah A. Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice. Sci Rep. 2017;7:1–13. doi:10.1038/s41598-017-17911-z
  • Mufson EJ, Counts SE, Perez SE, Ginsberg SD. Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications. Expert Rev Neurother. 2008;8:1703–18. Available from: http://www.tandfonline.com/doi/full/10.158614737175.8.11.1703
  • Iancu CV, Bocci G, Ishtikhar M, Khamrai M, Oreb M, Oprea TI, et al. GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic expression systems. Sci Rep. 2022;12:1–13. doi:10.1038/s41598-022-05383-9
  • Shah K, DeSilva S, Abbruscato T. The role of glucose transporters in brain disease: diabetes and Alzheimer’s disease. Int J Mol Sci. 2012;13:12629–55.
  • Hernandez AR, Hernandez CM, Campos K, Truckenbrod L, Federico Q, Moon B, et al. A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus. Front Aging Neurosci. 2018;10:1–16.
  • Pinto A, Bonucci A, Maggi E, Corsi M, Businaro R. Anti-oxidant and anti-inflammatory activity of ketogenic diet: new perspectives for neuroprotection in Alzheimer’s disease. Antioxidants. 2018;7:1–16.
  • Valsamakis G, Arapaki A, Balafoutas D, Charmandari E, Vlahos NF. Diet-induced hypothalamic inflammation, phoenixin, and subsequent precocious puberty. Nutrients. 2021;13:1–9.
  • Gonzalez-Lima F, Barksdale BR, Rojas JC. Mitochondrial respiration as a target for neuroprotection and cognitive enhancement. Biochem Pharmacol. 2014;88:584–93. doi:10.1016/j.bcp.2013.11.010
  • Suissa L, Kotchetkov P, Guigonis JM, Doche E, Osman O, Pourcher T, et al. Ingested ketone ester leads to a rapid rise of acetyl-coa and competes with glucose metabolism in the brain of non-fasted mice. Int J Mol Sci. 2021;22:1–17.