Dietary vitamin B12 deficiency impairs motor function and changes neuronal survival and choline metabolism after ischemic stroke in middle-aged male and female mice

References

• Spence JD. Nutrition and risk of stroke. Nutrients. 2019;11(3). doi:10.3390/nu11030647.
   Web of Science ®Google Scholar
• Langan RC, Goodbred AJ. Vitamin B12 deficiency: recognition and management. Am Fam Physician. 2017 Sep;96(6):384–9.
   PubMed Web of Science ®Google Scholar
• Spence JD. Metabolic B12 deficiency: a missed opportunity to prevent dementia and stroke. Nutr Res. 2016;36(2):109–16. doi:10.1016/j.nutres.2015.10.003.
   PubMed Web of Science ®Google Scholar
• Andrès E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004 Aug;171(3):251–9. doi:10.1503/cmaj.1031155.
   PubMed Web of Science ®Google Scholar
• Castro R, Rivera I, Blom HJ, Jakobs C, de Almeida IT. Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview. J Inherit Metab Dis. 2006 Feb;29(1):3–20. doi:10.1007/s10545-006-0106-5.
   PubMed Web of Science ®Google Scholar
• Moridani M, Ben-Poorat S. Laboratory investigation of vitamin B12 deficiency. Lab Med. 2006 Mar;37(3):166–74. doi:10.1309/CVHKLE2R4W68K2NQ.
   Google Scholar
• Vogiatzoglou A, Refsum H, Johnston C, Smith SM, Bradley KM, de Jager C, et al., Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Neurology. 2008 Sep;71(11):826–32. doi:10.1212/01.wnl.0000325581.26991.f2.
   PubMed Web of Science ®Google Scholar
• Spence JD. Homocysteine-lowering therapy: a role in stroke prevention? Lancet Neurol. 2007 Sep;6(9):830–8. doi:10.1016/S1474-4422(07)70219-3.
   PubMed Web of Science ®Google Scholar
• Spence JD, Stampfer MJ. Understanding the complexity of homocysteine lowering with vitamins: the potential role of subgroup analyses. JAMA – J Am Med Assoc. 2011;306(23):2610–11. doi:10.1001/jama.2011.1834.
   PubMed Web of Science ®Google Scholar
• Ahmed S, Bogiatzi C, Hackman DG, Rutledge AC, Sposato LA, Khaw A, et al. Vitamin B 12 deficiency and hyperhomocysteinaemia in outpatients with stroke or transient ischaemic attack: a cohort study at an academic medical centre. BMJ Open. 2019;9(1):1–8. doi:10.1136/bmjopen-2018-026564.
   PubMed Web of Science ®Google Scholar
• Yahn G, Abato J, Jadavji N. Role of vitamin B12 deficiency in ischemic stroke risk and outcome. Neural Regen Res. 2021;16(3):558–566. doi:10.4103/1673-5374.291381.
   Web of Science ®Google Scholar
• Abato JE, Moftah M, Cron GO, Smith PD, Jadavji NM. Methylenetetrahydrofolate reductase deficiency alters cellular response after ischemic stroke in male mice. Nutr Neurosci. 2020. doi:10.1080/1028415X.2020.1769412.
   PubMed Web of Science ®Google Scholar
• Jadavji N, Emmerson JT, Shanmugalingam U, Willmore WG, Macfarlane AJ, Smith PD. A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke. Exp Neurol. 2018;309:14–22.
   PubMed Web of Science ®Google Scholar
• Jadavji NM, Emmerson J, Willmore WG, MacFarlane AJ, Smith P. B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke. Neurobiol Dis. 2017;103:89–100.
   PubMed Web of Science ®Google Scholar
• Labat-gest V, Tomasi S. Photothrombotic ischemia: a minimally invasive and reproducible photochemical cortical lesion model for mouse stroke studies. J Visualized Exp: JoVE. 2013 Jun;76:e50370. doi:10.3791/50370.
   Google Scholar
• Lee J-K, Kim J-E, Sivula M, Strittmatter SM. Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J Neurosci: Off J Soc Neurosci. 2004;24(27):6209–17. doi:10.1523/JNEUROSCI.1643-04.2004.
   PubMed Web of Science ®Google Scholar
• Flurkey K, Currer JM, Harrison DE. Mouse models in aging research. In: J Fox, S Barthold, M Davisson, C Newcommer, F Quimby, A Smith, editors. The-mouse-in-biomedical-research, normative biology, husbandry, and models. 2nd ed., vol. 3. Elsevier; 2007. p. 637–72. doi:10.1016/B978-012369454-6/50074-1.
   Google Scholar
• Reeves PG. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr. 1997 May;127(5):838S–41S. doi:10.1093/jn/127.5.838S.
   PubMedGoogle Scholar
• Bernard DJ, Pangilinan FJ, Cheng J, Molloy AM, Brody LC. Mice lacking the transcobalamin-vitamin B12 receptor, CD320, suffer from anemia and reproductive deficits when fed vitamin B12-deficient diet. Hum Mol Genet. 2018;27(20):3627–40. doi:10.1093/hmg/ddy267.
   PubMed Web of Science ®Google Scholar
• Balkaya M, Kröber J, Gertz K, Peruzzaro S, Endres M. Characterization of long-term functional outcome in a murine model of mild brain ischemia. J Neurosci Methods. 2013 Mar;213(2):179–87. doi:10.1016/j.jneumeth.2012.12.021.
   PubMed Web of Science ®Google Scholar
• Jadavji NM, Farr TD, Lips J, Khalil AA, Boehm-Sturm P, Foddis M, et al. Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment. Behav Brain Res. 2015;283:215–26. doi:10.1016/j.bbr.2015.01.040.
   PubMed Web of Science ®Google Scholar
• Theoret JK, Jadavji NM, Zhang M, Smith PD. Granulocyte macrophage colony-stimulating factor treatment results in recovery of motor function after white matter damage in mice. Eur J Neurosci. 2016;43(1). doi:10.1111/ejn.13105.
   PubMed Web of Science ®Google Scholar
• Ducros V, Belva-Besnet H, Casetta B, Favier A. A robust liquid chromatography tandem mass spectrometry method for total plasma homocysteine determination in clinical practice. Clinical Chem Lab Med (CCLM). 2006 Jan;44(8):987–90. doi:10.1515/CCLM.2006.178.
   Google Scholar
• Jensen EC. Quantitative analysis of histological staining and fluorescence using Imagej. Anat Rec. 2013 Mar;296(3):378–81. doi:10.1002/ar.22641.
   Google Scholar
• Koc H, Mar MH, Ranasinghe A, Swenberg JA, Zeisel SH. Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry. Anal Chem. 2002;74(18):4734–40.
   PubMed Web of Science ®Google Scholar
• Spence JD. Stroke nutrition in stroke prevention. Skull Base. 2017;37:45–51. doi:10.1055/s-0037-1603470.
   Google Scholar
• Huijts M, Duits A, Staals J, van Oostenbrugge RJ. Association of vitamin B12 deficiency with fatigue and depression after lacunar stroke. PLoS One. 2012;7(1):e30519. doi:10.1371/journal.pone.0030519.
   PubMed Web of Science ®Google Scholar
• Cirillo C, et al. Post-stroke remodeling processes in animal models and humans. J Cereb Blood Flow Metab. 2020 Jan;40(1):3–22. doi:10.1177/0271678X19882788.
   PubMed Web of Science ®Google Scholar
• Sairanen T, Karjalainen-Lindsberg M-L, Paetau A, Ijäs P, Lindsberg PJ. Apoptosis dominant in the periinfarct area of human ischaemic stroke – a possible target of antiapoptotic treatments. Brain. 2006 Jan;129(Pt 1):189–99. doi:10.1093/brain/awh645.
   PubMed Web of Science ®Google Scholar
• Uzdensky AB. Photothrombotic stroke as a model of ischemic stroke. Transl Stroke Res. 2018 Oct;9(5):437–51. doi:10.1007/s12975-017-0593-8.
   PubMed Web of Science ®Google Scholar
• Kim T-H, Vemuganti R. Effect of sex and age interactions on functional outcome after stroke. CNS Neurosci Ther. 2015 Apr;21(4):327–36. doi:10.1111/cns.12346.
   PubMed Web of Science ®Google Scholar
• Compher C, Kinosian B, Stoner N, Lentine D, Buzby G. Choline and vitamin B12 deficiencies are interrelated in folate-replete long-term total parenteral nutrition patients. JPEN J Parenter Enteral Nutr. 2002 Jan;26(1):57–62. doi:10.1177/014860710202600157.
   PubMed Web of Science ®Google Scholar
• Hegsted DM, Roach AM, McCombs HL. Effect of vitamin B12 in choline deficiency in the rat. J Nutr. 1967 Jul;92(3):403–11. doi:10.1093/jn/92.3.403.
   PubMed Web of Science ®Google Scholar
• Selhub J, Bagley LC, Miller J, Rosenberg IH. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr. 2000 Feb;71(2):614S–20S.
   PubMed Web of Science ®Google Scholar
• Persky RW, Turtzo LC, McCullough LD. Stroke in women: disparities and outcomes. Curr Cardiol Rep. 2010;12(1):6–13. doi:10.1007/s11886-009-0080-2.
   PubMedGoogle Scholar
• Singh D, Wasan H, Reeta KH. Preclinical stroke research and translational failure: a bird’s eye view on preventable variables. Cell Mol Neurobiol. 2021 Mar. doi:10.1007/s10571-021-01083-6.
   Web of Science ®Google Scholar
• Margalit I, Cohen E, Goldberg E, Krause I. Vitamin B12 deficiency and the role of gender: a cross-sectional study of a large cohort. Ann Nutr Metab. 2018;72(4):265–71. doi:10.1159/000488326.
   PubMed Web of Science ®Google Scholar
• Bushnell CD, et al. Sex differences in stroke: challenges and opportunities. J Cereb Blood Flow Metab. 2018 Dec;38(12):2179–91. doi:10.1177/0271678X18793324.
   PubMed Web of Science ®Google Scholar