Nutrition is associated with differences in multisensory integration in healthy older adults

References

• Gehlich KH, Beller J, Lange-Asschenfeldt B, Köcher W, Meinke MC, Lademann J. Consumption of fruits and vegetables: improved physical health, mental health, physical functioning and cognitive health in older adults from 11 European countries. Aging Ment Health. 2020;24(4):634–641.
   PubMed Web of Science ®Google Scholar
• Jiang X, Huang J, Song D, Deng R, Wei J, Zhang Z. Increased consumption of fruit and vegetables is related to a reduced risk of cognitive impairment and dementia: meta-analysis. Front Aging Neurosci. 2017;9:18.
   PubMed Web of Science ®Google Scholar
• Lamport DJ, Saunders C, Butler LT, Spencer JP. Fruits, vegetables, 100% juices, and cognitive function. Nutr Rev. 2014;72(12):774–789.
   PubMed Web of Science ®Google Scholar
• Polidori MC, Praticó D, Mangialasche F, Mariani E, Aust O, Anlasik T. High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. J Alzheimer's Dis. 2009;17(4):921–927.
   PubMed Web of Science ®Google Scholar
• Martin A, Cherubini A, Andres-Lacueva C, Paniagua M, Joseph J. Effects of fruits and vegetables on levels of vitamins E and C in the brain and their association with cognitive performance. J Nutr Health Aging. 2002;6(6):392–404. https://pubmed.ncbi.nlm.nih.gov/12459890/.
   PubMedGoogle Scholar
• O’Connor DM, Scarlett S, De Looze C, ’Halloran O, Laird AM, Molloy E, M A. Low folate predicts accelerated cognitive decline: 8-year follow-up of 3140 older adults in Ireland. Eur J Clin Nutr. 2022;76:950–957.
   PubMed Web of Science ®Google Scholar
• Liu W, Xing S, Wei F, Yao Y, Zhang H, Li YC, Liu Z. Excessive dietary salt intake exacerbates cognitive impairment progression and increases dementia risk in older adults. J Am Med Dir Assoc. 2023;24(1):125–129.e4.
   PubMed Web of Science ®Google Scholar
• Beilharz JE, Maniam J, Morris MJ. Diet-induced cognitive deficits: the role of fat and sugar, potential mechanisms and nutritional interventions. Nutrients. 2015;7(8):6719–6738.
   PubMed Web of Science ®Google Scholar
• Reichelt AC, Stoeckel LE, Reagan LP, Winstanley CA, Page KA. Dietary influences on cognition. Physiol Behav. 2018;192:118–126.
   PubMed Web of Science ®Google Scholar
• Yeomans MR. Adverse effects of consuming high fat–sugar diets on cognition: implications for understanding obesity. Proc Nutr Soc. 2017;76(4):455–465.
   PubMed Web of Science ®Google Scholar
• Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK, Bruce-Keller AJ. Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol. 2010;219(1-2):25–32.
   PubMed Web of Science ®Google Scholar
• Jamar G, Ribeiro DA, Pisani LP. High-fat or high-sugar diets as trigger inflammation in the microbiota-gut-brain axis. Crit Rev Food Sci Nutr. 2021;61(5):836–854.
   PubMed Web of Science ®Google Scholar
• Hu LI, Zhu S, Peng X, Li K, Peng W, Zhong Y, et al. High salt elicits brain inflammation and cognitive dysfunction, accompanied by alternations in the gut microbiota and decreased SCFA production. J Alzheimer's Dis. 2020;77(2):629–640.
   PubMed Web of Science ®Google Scholar
• Agrón E, Mares J, Clemons TE, Swaroop A, Chew EY, Keenan TD. Dietary nutrient intake and progression to late age-related macular degeneration in the age-related eye disease studies 1 and 2. Ophthalmology. 2021;128(3):425–442.
   PubMed Web of Science ®Google Scholar
• Sardone R, Lampignano L, Guerra V, Zupo R, Donghia R, Castellana F, et al. Relationship between inflammatory food consumption and age-related hearing loss in a prospective observational cohort: results from the salus in apulia study. Nutrients. 2020;12(2):426.
   PubMed Web of Science ®Google Scholar
• Wallace MT, Woynaroski TG, Stevenson RA. Multisensory integration as a window into orderly and disrupted cognition and communication. Annu Rev Psychol. 2020;71:193–219.
   PubMed Web of Science ®Google Scholar
• Paraskevoudi N, Balcı F, Vatakis A. “Walking” through the sensory, cognitive, and temporal degradations of healthy aging. Ann N Y Acad Sci. 2018;1426(1):72–92.
   Web of Science ®Google Scholar
• Hirst RJ, McGovern DP, Setti A, Shams L, Newell FN. What you see is what you hear: twenty years of research using the Sound-Induced Flash Illusion. Neurosci Biobehav Rev. 2020;118:759–774.
   PubMed Web of Science ®Google Scholar
• Hernández B, Setti A, Kenny RA, Newell FN. Individual differences in ageing, cognitive status, and sex on susceptibility to the sound-induced flash illusion: a large-scale study. Psychol Aging. 2019;34(7):978.
   PubMed Web of Science ®Google Scholar
• McGovern DP, Roudaia E, Stapleton J, McGinnity TM, Newell FN. The sound-induced flash illusion reveals dissociable age-related effects in multisensory integration. Front Aging Neurosci. 2014;6:250.
   PubMed Web of Science ®Google Scholar
• Setti A, Burke KE, Kenny RA, Newell FN. Is inefficient multisensory processing associated with falls in older people? Exp Brain Res. 2011;209:375–384.
   PubMed Web of Science ®Google Scholar
• Shams L, Kamitani Y, Shimojo S. What you see is what you hear. Nature. 2000;408(6814):788–788.
   PubMed Web of Science ®Google Scholar
• Chan JS, Kaiser J, Brandl M, Matura S, Prvulovic D, Hogan MJ, Naumer MJ. Expanded temporal binding windows in people with mild cognitive impairment. Curr Alzheimer Res. 2015;12(1):61–68.
   PubMed Web of Science ®Google Scholar
• Hirst RJ, Setti A, De Looze C, Kenny RA, Newell FN. Multisensory integration precision is associated with better cognitive performance over time in older adults: a large-scale exploratory study. Aging Brain. 2022;2:100038.
   PubMedGoogle Scholar
• Setti A, Hernández B, Hirst RJ, Donoghue OA, Kenny RA, Newell FN. Susceptibility to the sound-induced flash illusion is associated with gait speed in a large sample of middle-aged and older adults. Exp Gerontol. 2023;174:112113.
   PubMed Web of Science ®Google Scholar
• O'Dowd A, Hirst RJ, Setti A, Kenny RA, Newell FN. Longitudinal grip strength is associated with susceptibility to the Sound Induced Flash Illusion in older adults. Aging Brain. 2023;3:100076.
   PubMedGoogle Scholar
• McGovern DP, Burns S, Hirst RJ, Newell FN. Perceptual training narrows the temporal binding window of audiovisual integration in both younger and older adults. Neuropsychologia. 2022;173:108309.
   PubMed Web of Science ®Google Scholar
• Whelan BJ, Savva GM. Design and methodology of the Irish longitudinal study on ageing. J Am Geriatr Soc. 2013;61:S265–S268.
   PubMed Web of Science ®Google Scholar
• Health Service Executive. Healthy Eating Guidelines. 2023. https://www.hse.ie/eng/about/who/healthwellbeing/our-priority-programmes/heal/healthy-eating-guidelines/.
   Google Scholar
• O'Connor D, Leahy S, McGarrigle C. Consumption patterns and adherence to the food pyramid. In: C McGarrigle, O Donoghue, S Scarlett, RA Kenny, editors. Health and wellbeing: active ageing for older adults in Ireland. evidence from The Irish longitudinal study on ageing. Dublin: The Irish Longitudinal Study on Ageing.; 2017. p. 76–97. https://tilda.tcd.ie/publications/reports/pdf/w3-key-findings-report/Chapter%204.pdf.
   Google Scholar
• R Core Team R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2021. https://www.R-project.org/.
   Google Scholar
• RStudio: integrated development environment for R. RStudio, PBC, Boston, MA. 2021. http://www.rstudio.com
   Google Scholar
• Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. arXiv preprint arXiv:1406.5823. 2014.
   Google Scholar
• Araújo JR, Martel F, Borges N, Araújo JM, Keating E. Folates and aging: role in mild cognitive impairment, dementia and depression. Ageing Res Rev. 2015;22:9–19.
   PubMed Web of Science ®Google Scholar
• Jensen DE, Leoni V, Klein-Flügge MC, Ebmeier KP, Suri S. Associations of dietary markers with brain volume and connectivity: a systematic review of MRI studies. Ageing Res Rev. 2021;70:101360.
   PubMed Web of Science ®Google Scholar
• Lau FC, Shukitt-Hale B, Joseph JA. Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress. Inflammation in the Pathogenesis of Chronic Diseases: the COX-2 Controversy. 2007; 299-318. https://pubmed.ncbi.nlm.nih.gov/17612057/.
   Google Scholar
• Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018: 757–772.
   PubMed Web of Science ®Google Scholar
• Scarpina F, Marzullo P, Mai S, Mauro A, Scacchi M, Costantini M. Altered temporal sensitivity in obesity is linked to pro-inflammatory state. Sci Rep. 2019;9(1):15508.
   PubMedGoogle Scholar
• Esmaillzadeh A, Kimiagar M, Mehrabi Y, Azadbakht L, Hu FB, Willett WC. Fruit and vegetable intakes, C-reactive protein, and the metabolic syndrome. Am J Clin Nutr. 2006;84(6):1489–1497.
   PubMed Web of Science ®Google Scholar
• Dhailappan A, Samiappan S. Impact of diet on neurotransmitters. In: S Rajagopal, S Ramachandran, G Sundararaman, S Gadde Venkata, editor. Role of nutrients in neurological disorders. Singapore: Springer Singapore; 2022. p. 363–383. https://link.springer.com/chapter/10.1007978-981-16-8158-5_20.
   Google Scholar
• Gao F, Edden RA, Li M, Puts NA, Wang G, Liu C. Edited magnetic resonance spectroscopy detects an age-related decline in brain GABA levels. Neuroimage. 2013;78:75–82.
   PubMed Web of Science ®Google Scholar
• Balz J, Keil J, Romero YR, Mekle R, Schubert F, Aydin S, et al. GABA concentration in superior temporal sulcus predicts gamma power and perception in the sound-induced flash illusion. Neuroimage. 2016;125:724–730.
   PubMed Web of Science ®Google Scholar
• David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559–563.
   PubMed Web of Science ®Google Scholar
• Othaim AA, Voreades N, Goodwin N, Curley J, Marasini D, Weir T, Carbonero F. Amounts and botanical diversity of dietary fruits and vegetables affect distinctly the human gut microbiome. Curr Dev Nutr. 2020;4(Supplement_2):1545–1545.
   Google Scholar
• Canipe III LG, Sioda M, Cheatham CL. Diversity of the gut-microbiome related to cognitive behavioral outcomes in healthy older adults. Arch Gerontol Geriatr. 2021;96:104464.
   PubMed Web of Science ®Google Scholar
• Komanduri M, Savage K, Lea A, McPhee G, Nolidin K, Deleuil S, et al. The relationship between gut microbiome and cognition in older Australians. Nutrients. 2022;14(1):64.
   Web of Science ®Google Scholar
• de JR De-Paula V, Forlenza AS, Forlenza OV. Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease. Pharmacol Res. 2018;136:29–34.
   PubMed Web of Science ®Google Scholar
• Setti A, Stapleton J, Leahy D, Walsh C, Kenny RA, Newell FN. Improving the efficiency of multisensory integration in older adults: audio-visual temporal discrimination training reduces susceptibility to the sound-induced flash illusion. Neuropsychologia. 2014;61:259–268.
   PubMed Web of Science ®Google Scholar
• Merriman NA, Whyatt C, Setti A, Craig C, Newell FN. Successful balance training is associated with improved multisensory function in fall-prone older adults. Comput Human Behav. 2015;45:192–203.
   Web of Science ®Google Scholar
• Maharjan R, Bustamante LD, Ghattas KN, Ilyas S, Al-Refai R, Khan S. Role of lifestyle in neuroplasticity and neurogenesis in an aging brain. Cureus. 2020;12(9):10639.
   Web of Science ®Google Scholar
• Shams L, Seitz AR. Benefits of multisensory learning. Trends Cogn Sci. 2008;12(11):411–417.
   PubMed Web of Science ®Google Scholar
• Ye X, Bhupathiraju SN, Tucker KL. Variety in fruit and vegetable intake and cognitive function in middle-aged and older Puerto Rican adults. Br J Nutr. 2013;109(3):503–510.
   PubMed Web of Science ®Google Scholar
• Shiraseb F, Siassi F, Qorbani M, Sotoudeh G, Rostami R, Narmaki E, et al. Higher dietary diversity is related to better visual and auditory sustained attention. Br J Nutr. 2016;115(8):1470–1480.
   PubMed Web of Science ®Google Scholar