Early morphological and neurochemical changes of the bed nucleus of stria terminalis (BNST) in gestational protein-restricted male offspring

References

• World Health Organization. Global targets 2025 to improve maternal, infant, and young child nutrition. 2015. http://www.who.int/nutrition/topics/nutrition_globaltargets2025/en/index.html.
   Google Scholar
• Ashton N. Perinatal development, and adult blood pressure. Braz J Med Biol Res. 2000;33:731–40.
   PubMed Web of Science ®Google Scholar
• Sene LB, Mesquita FF, de Moraes LN, Santos DC, Carvalho R, Gontijo JA, Boer PA. Involvement of renal corpuscle microRNA expression on epithelial-to-mesenchymal transition in maternal low protein diet in adult programmed rats. PLoS One. 2013;19(8):e71310. doi:10.1371/journal.pone.0071310
   Google Scholar
• Sene LB, Rizzi VHG, Gontijo JAR, Boer PA. Gestational low-protein intake enhances whole-kidney miR-192 and miR-200 family expression and epithelial-to-mesenchymal transition in rat adult male offspring. J Exp Biol. 2018;221:jeb171694. doi: 10.1242/jeb.171694.
   PubMed Web of Science ®Google Scholar
• Sene LB, Scarano WR, Zapparoli A, Gontijo JAR, Boer PA. Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus. PLoS One. 2021;16(2):e0246289. doi:10.1371/journal.pone.0246289.
   PubMed Web of Science ®Google Scholar
• Lamana GL, Ferrari ALL, Gontijo JAR, Boer PA. Gestational and breastfeeding low-protein intake on blood pressure, kidney structure, and renal function in male rat offspring in adulthood. Front Physiol. 2021;12:658431. doi:10.3389/fphys.2021.658431.
   PubMed Web of Science ®Google Scholar
• Mariano VS, Boer PA, Gontijo JAR. Fetal undernutrition programming, sympathetic nerve activity, and arterial hypertension development. Front Physiol. 2021. 10.3389/fphys.2021.704819
   PubMed Web of Science ®Google Scholar
• Burd L, Severud R, Kerbeshian J, Klug MG. Prenatal and perinatal risk factors for autism. J Perinat Med. 1999;27:441–50.
   PubMed Web of Science ®Google Scholar
• Grigoletti-Lima GB, Lopes MG, Barufi Franco AT, Damico AM, Boer PA, Gontijo JAR. Severe gestational low-protein intake impacts hippocampal cellularity, tau, and amyloid- levels, and memory performance in male adult offspring: an Alzheimer-simile disease model? J Alzheimer’s Dis Rep. 2022;6(1):17–30. doi: 10.3233/ADR-210297.
   PubMedGoogle Scholar
• Barker DJ. Fetal origins of coronary heart disease. Br Med J. 1995;311(6998):171–4. doi:10.1136/bmj.311.6998.171.
   PubMed Web of Science ®Google Scholar
• Barker DJ. The fetal and infant origins of disease. Eur J Clin Invest. 1995;25:457–63.
   PubMed Web of Science ®Google Scholar
• Barker DJP, Osmond C, Golding J, Kuh D, Wadsworth MEJ. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. Br Med J. 1989;298:564–7.
   PubMed Web of Science ®Google Scholar
• de Lima MC, Scabora JE, Lopes A, Mesquita FF, Torres D, Boer PA, Gontijo JAR. Early changes of hypothalamic angiotensin II receptors expression in gestational protein-restricted offspring: effect on water intake, blood pressure and renal sodium handling. J Renin-Angiotensin-Aldosterone Syst. 2013;14(3):271–82. 10.1177/1470320312456328.
   PubMed Web of Science ®Google Scholar
• Scabora JE, Lima MC, Lopes A, Lima IP, Mesquita FF, Torres DB, et al. Impact of taurine supplementation on blood pressure in gestational protein-restricted offspring: Effect on the medial solitary tract nucleus cell numbers, angiotensin receptors, and renal sodium handling. J Renin Angiotensin Aldosterone Syst. 2015;16(1):47–58. doi: 10.1177/1470320313481255.
   PubMed Web of Science ®Google Scholar
• Torres DB, Lopes A, Rodrigues AJ, Cerqueira JJ, Sousa N, Gontijo JAR, Boer PA. Anxiety-like behavior and structural changes of the bed nucleus of the stria terminalis (BNST) in gestational protein-restricted male offspring. J DOHAD. 2018;9:536–43. 10.1017/S2040174418000399.
   Google Scholar
• Torres DB, Lopes A, Rocrigues AJ, Lopes MG, Ventura-Silva AP, Sousa N, et al. Gestational protein restriction alters early amygdala neurochemistry in male offspring. Nutritional Neurosci. 2022: 1–17. 10.1080/1028415X.2022.2131064.
   Web of Science ®Google Scholar
• Lopes A, Torres DB, Rodrigues AJ, Cerqueira JJ, Pêgo JM, Sousa N, et al. Gestational protein restriction induces CA3 dendritic atrophy in dorsal hippocampal neurons but does not alter learning and memory performance in adult offspring. Int J Dev Neurosci. 2012;31(3):151–6. doi: 10.1016/j.ijdevneu.2012.12.003.
   PubMed Web of Science ®Google Scholar
• Benediktsson R, Lindsay RS, Noble J, Seckl JR, Edwards CR. Glucocorticoid exposure in utero: new model for adult hypertension. Lancet. 1993;341:339–41.
   PubMed Web of Science ®Google Scholar
• Stewart PM, Whorwood CB, Mason JI. Type-2 11-beta-hydroxysteroid dehydrogenase in foetal and adult life. J Steroid Biochem Mol Biol. 1995;55:465–71.
   PubMed Web of Science ®Google Scholar
• Langley-evans SC, Welham SJ, Sherman RC, Jackson AA. Weanling rats exposed to maternal low-protein diets during discrete periods of gestation exhibit differing severity of hypertension. Clin Sci (Lond). 1996;91:607–15.
   PubMed Web of Science ®Google Scholar
• Langley-Evans SC, Phillips GJ, Benediktsson R, et al. Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat. Placenta. 1996;17:169–72.
   PubMed Web of Science ®Google Scholar
• Langley-Evans SC. Maternal carbenoxolone treatment lowers birthweight and induces hypertension in the offspring of rats fed a protein-replete diet. Clin Sci (Lond). 1997;93(5):423–9.
   PubMed Web of Science ®Google Scholar
• Langley-Evans SC. Intrauterine programming of hypertension by glucocorticoids. Life Sci. 1997;60(15):1213–21.
   PubMed Web of Science ®Google Scholar
• Welberg LA, Seckl JR. Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol. 2001;13(2):113–28.
   PubMed Web of Science ®Google Scholar
• Ding YX, Shi Y, Han WJ, Cui H. 2016. Regulation of glucocorticoid related genes and receptors/regulatory enzyme expression in intrauterine growth restriction filial rats. Life Sci. doi: 10.1016/j.lfs.2016.02.079.
   Web of Science ®Google Scholar
• Oliveira M, Rodrigues AJ, Leão P, Cardona D, Pêgo JM, Sousa N. The bed nucleus of stria terminalis and the amygdala as targets of antenatal glucocorticoids: implications for fear and anxiety responses. Psychopharmacology (Berl). 2012;220(3):443–53. doi: 10.1007/s00213-011-2494-y.
   PubMedGoogle Scholar
• Walker DL, Toufexis DJ, Davis M. Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. Eur J Pharmacol. 2003;463(1-3):199–216.
   PubMed Web of Science ®Google Scholar
• Pêgo JM, Morgado P, Pinto LG. Dissociation of the morphological correlates of stress-induced anxiety and fear. Eur J Neurosci. 2008;27(6):1503–16.
   PubMed Web of Science ®Google Scholar
• Kream J, Mulay S, Fukushima DK, Solomon S. Determination of plasma dexamethasone in the mother and the newborn after administration of the hormone in a clinical trial. J Clin Endocrinol Metab. 1983;56(1):127–33.
   PubMed Web of Science ®Google Scholar
• Gomez-Sanchez EP. Mineralocorticoid receptors in the brain and cardiovascular regulation: minority rule? Trends Endocrinol Metab. 2011;22(5):179–87.
   PubMed Web of Science ®Google Scholar
• Davis M. The Role of the Amygdala in Fear and Anxiety. Ann Rev Neurosci. 1992;15:353–75.
   PubMed Web of Science ®Google Scholar
• Davis M. The role of the amygdala in emotional learning. Int Rev Neurobiol. 1994;36:225–66. doi:10.1016/S0074-7742(08)60305-0.
   PubMed Web of Science ®Google Scholar
• Merali Z, Khan S, Michaud DS, Shinosito L, Phosphatepy SA, Anisman H. Does amygdaloid corticotropin-releasing hormone (CRF) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRF release. Eur J Neurosci. 2004;20(1):229–39.
   PubMed Web of Science ®Google Scholar
• Mesquita AR, Pêgo JM, Summavielle T, Maciel P, Almeida OF, Sousa N. Neurodevelopment milestone abnormalities in rats exposed to stress in early life. Neuroscience. 2007;147(4):1022–33.
   PubMed Web of Science ®Google Scholar
• Muller MB. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat. Neurosci. 2003;6(10):1100–7.
   PubMed Web of Science ®Google Scholar
• Corominas M, Roncero C, Casas M. Corticotropin-releasing factor and neuroplasticity in cocaine addiction. Life Sci. 2010;86:1–9.
   PubMed Web of Science ®Google Scholar
• Millan MJ. Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie. 2005;60(5):441–60.
   PubMed Web of Science ®Google Scholar
• Holsboer F. Corticotropin-releasing hormone modulators and depression. Curr Opin Investig Drugs. 2003;4:46–50.
   PubMedGoogle Scholar
• Nestler EJ, Barrot M, Dileone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron. 2002;34(1):13–25.
   PubMed Web of Science ®Google Scholar
• Leonard BE. The HPA and immune axes in stress: the involvement of the serotonergic system. Eur Psychiatry. 2005;20(S3):302–6.
   Google Scholar
• Holmes A, Heilig M, Rupniak NM, Steckler T, Griebel G. Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders. Trends Pharmacol Sci 2003;24:580–8.
   PubMed Web of Science ®Google Scholar
• Fontenot MB, Kaplan JR, Manuck SB, Arango V, Mann JJ. Long-term effects of chronic social stress on serotonergic indices in the prefrontal cortex of adult male cynomolgus macaques. Brain RES. 1995;705:105–8.
   PubMed Web of Science ®Google Scholar
• Hammack SE, Guo JD, Hazra R, Dabrowska J, Myers KM, Rainnie DG. The response of neurons in the bed nucleus of the stria terminalis to serotonin: implications for anxiety. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(8):1309–20.
   PubMed Web of Science ®Google Scholar
• Herculano-Houzel S, Lent R. Isotropic fractionator: a simple, rapid method for the quantification of total cell and neuron numbers in the brain. J Neurosci. 2005;25(10):2518–21.
   PubMed Web of Science ®Google Scholar
• Gibb R, Kolb B. A method for vibratome sectioning of Golgi-Cox stained whole rat brain. J Neurosci Methods. 1998;79:1–4.
   PubMed Web of Science ®Google Scholar
• Glaser EM, Van der Loos H. Analysis of thick brain sections by obverse-reverse computer microscopy: application of a new, high clarity Golgi-Nissl stain. J Neurosci Methods. 1981;4:117–25.
   PubMed Web of Science ®Google Scholar
• Mcdonald AJ. Neurons of the bed nucleus of the stria terminalis: a Golgi study in the rat. Brain Res Bull. 1983;10(1):111–20.
   PubMed Web of Science ®Google Scholar
• Sholl DA. The measurable parameters of the cerebral cortex and their significance in its organization. Prog Neurobiol. 1956;2:324–33.
   Google Scholar
• Mesquita FF, Gontijo JA, Boer PA. Expression of renin-angiotensin system signalling compounds in maternal protein-restricted rats: effect on renal sodium excretion and blood pressure. Nephrol Dial Transplant. 2010;25:380–8. doi: 10.1093/ndt/gfp505.
   PubMed Web of Science ®Google Scholar
• Mesquita FF, Gontijo JAR, Boer PA. Maternal undernutrition and the offspring kidney: from fetal to adult life. Braz J Med Biol Res. 2010;43(11):1010–8. doi:10.1590/S0100-879X2010007500113.
   PubMed Web of Science ®Google Scholar
• Zambrano E, Bautista CJ, Deás M, Martínez-Samayoa PM, González Zamorano M, Ledesma H, et al. 2006. A low maternal protein diet during pregnancy and lactation has sex- and window of exposure-specific effects on offspring growth and food intake, glucose metabolism, and serum leptin in the rat. J Physiol 571(1):221–30.
   PubMed Web of Science ®Google Scholar
• Kwong WY, Wild AE, Roberts P, Willis AC, Fleming TP. Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. Development. 2000;127:4195–202.
   PubMed Web of Science ®Google Scholar
• Gillette R, Reilly MP, Topper VY, et al. Anxiety-like behaviors in adulthood are altered in male but not female rats exposed to low dosages of polychlorinated biphenyls in utero. Hormone Behav. 2017;87:8–15.
   PubMed Web of Science ®Google Scholar
• Woodall S, Johnston BM, Breier BH, Gluckman P. Chronic Maternal Undernutrition in the Rat Leads to Delayed Postnatal Growth and Elevated Blood Pressure of Offspring. Pediatr Res. 1996;40(3):438–43. doi:10.1203/00006450-199609000-00012.
   PubMed Web of Science ®Google Scholar
• Lumbers ER, Yu ZY, Gibson KJ. The selfish brain and the Barker hypothesis. Clin Exp Pharmacol Physiol. 2001;28(11):942–7.
   PubMed Web of Science ®Google Scholar
• Li M, Guo K, Adachi Y, Ikehara S. Immune Dysfunction Associated with Abnormal Bone Marrow-Derived Mesenchymal Stroma Cells in Senescence Accelerated Mice. Int J Mol Sci. 2016;29(2):183. doi: 10.3390/ijms17020183.
   Google Scholar
• Ventura-Silva AP, Pêgo JM, Sousa JC, Marques AR, Rodrigues AJ, Marques F, et al. Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode. Eur J Neurosci. 2012;36(10):3396–406. doi: 10.1111/j.1460-9568.2012.08262.x.
   PubMed Web of Science ®Google Scholar
• Drake AJ, Tang JI, Nyirenda MJ. Mechanisms underlying the role of glucocorticoids in the early life programming of adult disease. Clin Sci (Lond). 2007;113(5):219–32.
   PubMed Web of Science ®Google Scholar
• Weinstock M, Matlina E, Maor GI, Rosen H, Mcewen BS. . Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary-adrenal system in the female rat. Brain Res 1992;595(2):195-200
   PubMed Web of Science ®Google Scholar
• Fameli M, Kitraki E, Stylianopoulou F. Effects of hyperactivity of the maternal hypothalamic-pituitary-adrenal (HPA) axis during pregnancy on the development of the HPA axis and brain monoamines of the offspring. Int J Dev Neurosci. 1994;12(7):651–9.
   PubMed Web of Science ®Google Scholar
• Kim SY, Adhikari A, Lee SY, Marshel JH, Kim CK, Mallory CS, Lo M, Pak S, Mattis J, Lim BK, Malenka RC, Warden MR, Neve R, Tye KM, Deisseroth K. Diverging neural pathways assemble a behavioural state from separable features in anxiety. Nature. 2013;496(7444):219–23. doi: 10.1038/nature12018
   PubMed Web of Science ®Google Scholar
• Lima AD, Voigt T. Astroglia inhibit the proliferation of neocortical cells and prevent the generation of small GABAergic neurons in vitro. Eur J Neurosci. 1999;11(11):3845–56.
   PubMed Web of Science ®Google Scholar
• Forray MI, Gysling K. Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic-pituitary-adrenal axis. Brain Res Brain Res Rev. 2004;47(1-3):145–60.
   PubMedGoogle Scholar
• Hammack SE, Roman CW, Lezak KR, Kocho-Shellenberg M, Grimmig B, Falls WA, Braas K MAYV. Roles for pituitary adenylate cyclase-activating peptide (PACAP) expression, and signaling in the bed nucleus of the stria terminalis (BNST) in mediating the behavioral consequences of chronic stress. J Mol Neurosci. 2010;42(3):327–40.
   PubMed Web of Science ®Google Scholar
• Vyas A, Mitra R, Shankaranarayana RBS, Chattarji S. Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. Neurosci. 2002;22(15):6810–8.
   Web of Science ®Google Scholar
• Wood CE, Keller-Wood M. 2016. The critical importance of the fetal hypothalamus-pituitary-adrenal axis. F1000Res 28;5. doi: 10.12688/f1000research.7224.1. e Collection 2016.
   Google Scholar
• Sousa N, Cerqueira JJ, Almeida OF. Corticosteroid receptors and neuroplasticity. Brain Res Rev. 2008;57(2):561–70.
   PubMedGoogle Scholar
• de Kloet ER, Vreugdenhil E, Oitzl MS, Joëls M. Brain corticosteroid receptor balance in health and disease. Endocr Rev. 1998;19(3):269–301.
   PubMed Web of Science ®Google Scholar
• Leão P, Sousa JC, Oliveira M, Silva R, Almeida OF, Sousa N. Programming effects of antenatal dexamethasone in the developing mesolimbic pathways. Synapse. 2007;61(1):40–9.
   PubMed Web of Science ®Google Scholar
• Vyas A, Bernal S, Chattarji S. Effects of chronic stress on dendritic arborization in the central and extended amygdala. Brain Res. 2003;965(12):290–4.
   PubMedGoogle Scholar
• Charil A, Laplante D, Vaillancourt C, King S. Prenatal stress and brain development. Brain Res. 2010;65(1):56–79. doi: 10.1016/j.brainresrev.2010.06.002.
   Web of Science ®Google Scholar
• van donkelaar EL, van den Hove DL, Blokland A, Steinbusch HW, Prickaerts J. Stress-mediated decreases in brain-derived neurotrophic factor as a potential confounding factor for acute tryptophan depletion-induced neurochemical effects. Eur Neuropsychopharmacol. 2009;19(11):812–21. doi: 10.1016/j.euroneuro.2009.06.012.
   PubMed Web of Science ®Google Scholar
• Mattson MP, Maudsley S, Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2004;27(10):589–94.
   PubMed Web of Science ®Google Scholar
• Rial D, Lemos C, Pinheiro H, Duarte JM, Gonçalves FQ, Real JI, et al. Depression as a Glial-Based Synaptic Dysfunction. Front Cell Neurosci. 2016;9:521. doi: 10.3389/fncel.2015.00521.
   PubMed Web of Science ®Google Scholar
• Duman RS. Role of neurotrophic factors in the etiology and treatment of mood disorders. Neuromolecular Med. 2004;5(1):11–25.
   PubMed Web of Science ®Google Scholar
• Barrientos RM, Sprunger DB, Campeau S, Higgins EA, Watkins LR, Rudy JW, Maier SF. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonists. Neuroscience. 2003;121(4):847–53.
   PubMed Web of Science ®Google Scholar
• Ressler KJ, Nemeroff CB. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety Suppl. 2000;12(S1):2–19.
   PubMedGoogle Scholar
• Grahn RE, Maswood S, Mcqueen MB, Watkins LR, Maier SF. Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus. Behav Brain Res. 1999;99(2):153–67.
   PubMed Web of Science ®Google Scholar
• Lowry CA, Rodda JE, Lightman SL, Ingram CD. Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical serotonergic system. J Neurosci. 2000;20(20):7728–36.
   PubMed Web of Science ®Google Scholar
• Singewald N, Kouvelas D, Kaehler ST, Sinner C, Philippu A. Peripheral chemoreceptor activation enhances 5-hydroxytryptamine release in the locus coeruleus of conscious rats. Neurosci Lett. 2000;289(1):17–20.
   PubMed Web of Science ®Google Scholar
• Ciranna L. Serotonin as a modulator of glutamate- and GABA-mediated neurotransmission: implications in physiological functions and in pathology. Curr Neuropharmacol. 2006;4(2):101–14.
   PubMed Web of Science ®Google Scholar
• Dilts RP, Boadle-Biber MC. Differential activation of the 5-hydroxytryptamine-containing neurons of the midbrain raphe of the rat in response to randomly presented inescapable sound. Neurosci Lett. 1995;199(1):78–80.
   PubMed Web of Science ®Google Scholar
• Grahn RE, Will MJ, Hammack SE, Maswood S, Mcqueen MB, Watkins LR, Maier SF. Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor. Brain Res. 1999;826(1):35–43.
   PubMed Web of Science ®Google Scholar
• Takase LF, Nogueira MI, Baratta M, Bland ST, Watkins LR, Maier SF, et al. Inescapable shock activates serotonergic neurons in all raphe nuclei of the rat. Behav Brain Res. 2004;153(1):233–9.
   PubMed Web of Science ®Google Scholar
• Graeff FG, Guimarães FS, de Andrade TG, Deakin JF. Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav. 1996;54(1):129–41.
   PubMed Web of Science ®Google Scholar
• Handley SL, Mcblane JW, Critchley MA, Njung'e K. Multiple serotonin mechanisms in animal models of anxiety: environmental, emotional and cognitive factors. Behav Brain Res. 1993;58(1-2):203–10.
   PubMed Web of Science ®Google Scholar
• Handley SL. 5-Hydroxytryptamine pathways in anxiety and its treatment. Pharmacol Ther. 1995;66(1):103–48.
   PubMed Web of Science ®Google Scholar
• Lowry CA, Johnson PL, Hay-Schmidt A, Mikkelsen J, Shekhar A. Modulation of anxiety circuits by serotonergic systems. Stress. 2005;8:233–46.
   PubMed Web of Science ®Google Scholar
• Andreis DT, Singer M. Catecholamines for inflammatory shock: a Jekyll-and-Hyde conundrum. Intensive Care Med. 2016;42(9):1387–97.
   PubMed Web of Science ®Google Scholar
• Riedemann T, Patchev AV, Cho K, Almeida OF. Corticosteroids: way upstream. Mol Brain. 2010;3:2. doi: 10.1186/1756-6606-3-2.
   PubMed Web of Science ®Google Scholar
• Lymperopoulos A, Brill A, Mccrink KA. GPCRs of adrenal chromaffin cells & catecholamines: The plot thickens. Int J Biochem Cell Biol. 2016. doi: 10.1016/j.biocel.2016.02.003
   PubMed Web of Science ®Google Scholar
• Onaka T, Yagi K. Role of noradrenergic projections to the bed nucleus of the stria terminalis in neuroendocrine and behavioral responses to fear-related stimuli in rats. Brain Res. 1998;788:287–93.
   PubMed Web of Science ®Google Scholar
• Pacak K, Mccarty R, Palkovits M, Kopin IJ, Goldstein DS. Effects of immobilization on in vivo release of norepinephrine in the bed nucleus of the stria terminalis in conscious rats. Brain Res. 1995;688(1-2):242–6.
   PubMed Web of Science ®Google Scholar
• Oliveira M, Bessa JM, Mesquita A, Tavares H, Carvalho A, Silva R, et al. Induction of a hyperanxious state by antenatal dexamethasone: a case for less detrimental natural corticosteroids. Biol Psychiatry. 2006;59(9):844–52.
   PubMed Web of Science ®Google Scholar
• Piazza PV, le Moal ML. Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons. Annu Rev Pharmacol Toxicol. 1996;36:359–78.
   PubMed Web of Science ®Google Scholar
• Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med. 2016;22:238–49.
   PubMed Web of Science ®Google Scholar