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Research Article

Oxidative stress and neurodegenerative diseases: a bidirectional Mendelian randomization study

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  • Li D, Liu C. Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases. Nat Rev Neurosci. 2022;23:523–34. doi:10.1038/s41583-022-00603-7
  • Hansson O. Biomarkers for neurodegenerative diseases. Nat Med. 2021;27:954–963.
  • Rabbito A, Dulewicz M, Kulczyńska-Przybik A, Mroczko B. Biochemical markers in Alzheimer's disease. Int J Mol Sci. 2020;21:1989. doi:10.3390/ijms21061989
  • Gaugler J, James B, Johnson T, Reimer J, Solis M, Weuve J, et al. 2022 Alzheimer's disease facts and figures. Alzheimers Dement. 2022;18:700–89. doi:10.1002/alz.12638
  • Bastide MF, Meissner WG, Picconi B, Fasano S, Fernagut P, Feyder M, et al. Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease. Prog Neurobiol. 2015;132:96–168. doi:10.1016/j.pneurobio.2015.07.002
  • Melo A, Monteiro L, Lima RM, Oliveira DM, Cerqueira MD, El-Bachá RS. Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives. Oxid Med Cell Longev. 2011;2011:467180. doi:10.1155/2011/467180
  • Xu L, Liu T, Liu L, Yao X, Chen L, Fan D, et al. Global variation in prevalence and incidence of amyotrophic lateral sclerosis: a systematic review and meta-analysis. J Neurol. 2020;267:944–53. doi:10.1007/s00415-019-09652-y
  • Xu L, Chen L, Wang S, Feng J, Liu L, Liu G, et al. Incidence and prevalence of amyotrophic lateral sclerosis in urban China: a national population-based study. J Neurol Neurosurg Psychiatry. 2020;91:520–5. doi:10.1136/jnnp-2019-322317
  • Yan MH, Wang X, Zhu X. Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic Biol Med. 2013;62:90–101. doi:10.1016/j.freeradbiomed.2012.11.014
  • Baltazar MT, Dinis-Oliveira RJ, de Lourdes BM, Tsatsakis AM, Duarte JA, Carvalho F. Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases – a mechanistic approach. Toxicol Lett. 2014;230:85–103. doi:10.1016/j.toxlet.2014.01.039
  • Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006;443:787–95. doi:10.1038/nature05292
  • Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R. The association between vitamin D concentration and pain: a systematic review and meta-analysis. Public Health Nutr. 2018;21:2022–37. doi:10.1017/S1368980018000551
  • Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R. Effect of vitamin D supplementation on pain: a systematic review and meta-analysis. Pain Physician. 2016;19:415–27.
  • Niedzielska E, Smaga I, Gawlik M, Moniczewski A, Stankowicz P, Pera J, et al. Oxidative stress in neurodegenerative diseases. Mol Neurobiol. 2016;53:4094–125. doi:10.1007/s12035-015-9337-5
  • Kim GH, Kim JE, Rhie SJ, Yoon S. The role of oxidative stress in neurodegenerative diseases. Exp Neurobiol. 2015;24:325–40. doi:10.5607/en.2015.24.4.325
  • Poljsak B, Šuput D, Milisav I. Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxid Med Cell Longev. 2013;2013:956792. doi:10.1155/2013/956792
  • Lu Z, Pu C, Zhang Y, Sun Y, Liao Y, Kang Z, et al. Oxidative stress and psychiatric disorders: evidence from the bidirectional Mendelian randomization study. Antioxidants (Basel). 2022;11:1386.
  • Pisoschi AM, Pop A. The role of antioxidants in the chemistry of oxidative stress: a review. Eur J Med Chem. 2015;97:55–74. doi:10.1016/j.ejmech.2015.04.040
  • Zalewska A, Klimiuk A, Zięba S, Wnorowska O, Rusak M, Waszkiewicz N, et al. Salivary gland dysfunction and salivary redox imbalance in patients with Alzheimer's disease. Sci Rep. 2021;11:23904. doi:10.1038/s41598-021-03456-9
  • Bourdel-Marchasson I, Delmas-Beauvieux MC, Peuchant E, Richard-Harston S, Decamps A, Reignier B, et al. Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients. Age Ageing. 2001;30:235–41. doi:10.1093/ageing/30.3.235
  • Padurariu M, Ciobica A, Hritcu L, Stoica B, Bild W, Stefanescu C. Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett. 2010;469:6–10. doi:10.1016/j.neulet.2009.11.033
  • Schrag M, Mueller C, Zabel M, Crofton A, Kirsch WM, Ghribi O, et al. Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: a meta-analysis. Neurobiol Dis. 2013;59:100–10. doi:10.1016/j.nbd.2013.07.005
  • Foy CJ, Passmore AP, Vahidassr MD, Young IS, Lawson JT. Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease. Qjm. 1999;92:39–45. doi:10.1093/qjmed/92.1.39
  • Koppula S, Kumar H, More SV, Kim BW, Kim IS, Choi DK. Recent advances on the neuroprotective potential of antioxidants in experimental models of Parkinson's disease. Int J Mol Sci. 2012;13:10608–29. doi:10.3390/ijms130810608
  • Nikam S, Nikam P, Ahaley SK, Sontakke AV. Oxidative stress in Parkinson's disease. Indian J Clin Biochem. 2009;24:98–101. doi:10.1007/s12291-009-0017-y
  • Cova E, Bongioanni P, Cereda C, Metelli MR, Salvaneschi L, Bernuzzi S, et al. Time course of oxidant markers and antioxidant defenses in subgroups of amyotrophic lateral sclerosis patients. Neurochem Int. 2010;56:687–93. doi:10.1016/j.neuint.2010.02.004
  • Golenia A, Leśkiewicz M, Regulska M, Budziszewska B, Szczęsny E, Jagiełła J, et al. Catalase activity in blood fractions of patients with sporadic ALS. Pharmacol Rep. 2014;66:704–7. doi:10.1016/j.pharep.2014.02.021
  • Babu GN, Kumar A, Chandra R, Puri SK, Singh RL, Kalita J, et al. Oxidant-antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease. Neurochem Int. 2008;52:1284–9. doi:10.1016/j.neuint.2008.01.009
  • Kuźma M, Jamrozik Z, Barańczyk-Kuźma A. Activity and expression of glutathione S-transferase pi in patients with amyotrophic lateral sclerosis. Clin Chim Acta. 2006;364:217–21. doi:10.1016/j.cccn.2005.07.008
  • Thonhoff JR, Berry JD, Macklin EA, Beers DR, Mendoza PA, Zhao W, et al. Combined regulatory T-lymphocyte and IL-2 treatment is safe, tolerable, and biologically active for 1 year in persons with amyotrophic lateral sclerosis. Neurol Neuroimmunol Neuroinflamm. 2022;9:e200019. doi:10.1212/NXI.0000000000200019
  • Yang A, Wu J, Chen Y, Shen R, Kou X. Study on multi-target synergistic treatment of Alzheimer's disease based on metal chelators. Curr Drug Targets. 2023;24:131–150.
  • Aaseth J, Dusek P, Roos PM. Prevention of progression in Parkinson's disease. Biometals. 2018;31:737–47. doi:10.1007/s10534-018-0131-5
  • Jiang T, Sun Q, Chen S. Oxidative stress: a major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's disease. Prog Neurobiol. 2016;147:1–19. doi:10.1016/j.pneurobio.2016.07.005
  • Chen Z, Zhong C. Oxidative stress in Alzheimer's disease. Neurosci Bull. 2014;30:271–81. doi:10.1007/s12264-013-1423-y
  • Trist BG, Hare DJ, Double KL. Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease. Aging Cell. 2019;18:e13031. doi:10.1111/acel.13031
  • Cunha-Oliveira T, Montezinho L, Mendes C, Firuzi O, Saso L, Oliveira PJ, et al. Oxidative stress in amyotrophic lateral sclerosis: pathophysiology and opportunities for pharmacological intervention. Oxid Med Cell Longev. 2020;2020:5021694. doi:10.1155/2020/5021694
  • Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey SG. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2008;27:1133–63. doi:10.1002/sim.3034
  • Skrivankova VW, Richmond RC, Woolf B, Yarmolinsky J, Davies NM, Swanson SA, et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement. Jama. 2021;326:1614–21. doi:10.1001/jama.2021.18236
  • Skrivankova VW, Richmond RC, Woolf B, Davies NM, Swanson SA, VanderWeele TJ, et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomisation (STROBE-MR): explanation and elaboration. Br Med J. 2021;375:n2233. doi:10.1136/bmj.n2233
  • Sun BB, Maranville JC, Peters JE, Stacey D, Staley JR, Blackshaw J, et al. Genomic atlas of the human plasma proteome. Nature. 2018;558:73–9. doi:10.1038/s41586-018-0175-2
  • Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, et al. The MR-base platform supports systematic causal inference across the human phenome. Elife. 2018;7:e34408. doi:10.7554/eLife.34408
  • Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, et al. An atlas of genetic influences on human blood metabolites. Nat Genet. 2014;46:543–50. doi:10.1038/ng.2982
  • Li R, Deng M, Lin Y, Gao W, Liu B, Xia H. Genetically predicted circulating levels of glycine, glutamate, and serotonin in relation to the risks of three major neurodegenerative diseases: a Mendelian randomization analysis. Front Aging Neurosci. 2022;14:938408. doi:10.3389/fnagi.2022.938408
  • Cui G, Li S, Ye H, Yang Y, Huang Q, Chu Y, et al. Are neurodegenerative diseases associated with an increased risk of inflammatory bowel disease? A two-sample Mendelian randomization study. Front Immunol. 2022;13:956005. doi:10.3389/fimmu.2022.956005
  • Cullell N, Cárcel-Márquez J, Gallego-Fábrega C, Muiño E, Llucià-Carol L, Lledós M, et al. Sleep/wake cycle alterations as a cause of neurodegenerative diseases: A Mendelian randomization study. Neurobiol Aging. 2021;106:320–1. doi:10.1016/j.neurobiolaging.2021.05.008
  • Pierce BL, Ahsan H, Vanderweele TJ. Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants. Int J Epidemiol. 2011;40:740–52. doi:10.1093/ije/dyq151
  • Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37:658–65. doi:10.1002/gepi.21758
  • Teleanu DM, Niculescu AG, Lungu II, Radu CI, Vladâcenco O, Roza E, et al. An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases. Int J Mol Sci. 2022;23:5938.
  • Domanskyi A, Parlato R. Oxidative stress in neurodegenerative diseases. Antioxidants (Basel). 2022;11:504.
  • Wang H, Wu S, Wang L, Gou X, Guo X, Liu Z, et al. Association between serum total bilirubin and Alzheimer's disease: a bidirectional Mendelian randomization study. Arch Gerontol Geriatr. 2022;103:104786. doi:10.1016/j.archger.2022.104786
  • Cheng WW, Zhu Q, Zhang HY. Mineral nutrition and the risk of chronic diseases: a Mendelian randomization study. Nutrients. 2019;11:378.
  • Ashok A, Andrabi SS, Mansoor S, Kuang Y, Kwon BK, Labhasetwar V. Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: role of nanoparticle-based drug delivery systems in clinical translation. Antioxidants (Basel). 2022;11:408.
  • Kumar A, Singh A. A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditions. Front Pharmacol. 2015;6:206. doi:10.3389/fphar.2015.00206
  • Tzounakas VL, Anastasiadi AT, Arvaniti VZ, Lelli V, Fanelli G, Paronis EC, et al. Supplementation with uric and ascorbic acid protects stored red blood cells through enhancement of non-enzymatic antioxidant activity and metabolic rewiring. Redox Biol. 2022;57:102477. doi:10.1016/j.redox.2022.102477
  • Elango N, Samuel S, Chinnakkannu P. Enzymatic and non-enzymatic antioxidant status in stage (III) human oral squamous cell carcinoma and treated with radical radio therapy: influence of selenium supplementation. Clin Chim Acta. 2006;373:92–8. doi:10.1016/j.cca.2006.05.021
  • Gopi N, Vijayakumar S, Thaya R, Govindarajan M, Alharbi NS, Kadaikunnan S, et al. Chronic exposure of Oreochromis niloticus to sub-lethal copper concentrations: effects on growth, antioxidant, non-enzymatic antioxidant, oxidative stress and non-specific immune responses. J Trace Elem Med Biol. 2019;55:170–9. doi:10.1016/j.jtemb.2019.06.011
  • Sikora J, Ouagazzal AM. Synaptic zinc: an emerging player in Parkinson's disease. Int J Mol Sci. 2021;22:4724.
  • Anirudhan A, Angulo-Bejarano PI, Paramasivam P, Manokaran K, Kamath SM, Murugesan R, et al. RPL6: a key molecule regulating zinc- and magnesium-bound metalloproteins of Parkinson's disease. Front Neurosci. 2021;15:631892. doi:10.3389/fnins.2021.631892
  • Costa I, Barbosa DJ, Benfeito S, Silva V, Chavarria D, Borges F, et al. Molecular mechanisms of ferroptosis and their involvement in brain diseases. Pharmacol Ther. 2023;244:108373. doi:10.1016/j.pharmthera.2023.108373
  • Fryer MJ. Vitamin E status and neurodegenerative disease. Nutr Neurosci. 1998;1:327–51. doi:10.1080/1028415X.1998.11747243
  • Cacabelos D, Ayala V, Granado-Serrano AB, Jové M, Torres P, Boada J, et al. Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis. Neurobiol Dis. 2016;88:148–60. doi:10.1016/j.nbd.2016.01.007
  • Michal FD, Kuncl RW, Weinstein SJ, Malila N, Virtamo J, Albanes D. Vitamin E serum levels and controlled supplementation and risk of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2013;14:246–51. doi:10.3109/21678421.2012.745570
  • Boccardi V, Carino S, Marinelli E, Lapenna M, Caironi G, Bianco AR, et al. Uric acid and late-onset Alzheimer's disease: results from the ReGAl 2.0 project. Aging Clin Exp Res. 2021;33:361–6. doi:10.1007/s40520-020-01541-z
  • Du N, Xu D, Hou X, Song X, Liu C, Chen Y, et al. Inverse association between serum uric acid levels and Alzheimer's disease risk. Mol Neurobiol. 2016;53:2594–9. doi:10.1007/s12035-015-9271-6
  • Qiao M, Chen C, Liang Y, Luo Y, Wu W. The influence of serum uric acid level on Alzheimer's disease: a narrative review. Biomed Res Int. 2021;2021:5525710.
  • Ye BS, Lee WW, Ham JH, Lee JJ, Lee PH, Sohn YH. Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline? Eur J Neurol. 2016;23:948–57. doi:10.1111/ene.12969
  • Kim JW, Byun MS, Yi D, Lee JH, Jeon SY, Ko K, et al. Serum uric acid, Alzheimer-related brain changes, and cognitive impairment. Front Aging Neurosci. 2020;12:160. doi:10.3389/fnagi.2020.00160

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