Publication Cover
Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Latest Articles
61
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Synergistic effect of chrysin and kaempferol in ameliorating Cerebral Ischemic Reperfusion injury in rat by controlling expression of proinflammatory mediators NF-κB and STAT3

, & ORCID Icon

References

  • Bathla G, Ajmera P, Mehta PM, Benson JC, Derdeyn CP, Lanzino G, et al. Advances in acute ischemic stroke treatment: current status and future directions. Am J Neuroradiol. 2023 May 18;44(7):750–758.
  • Ahad MA, Kumaran KR, Ning T, Mansor NI, Effendy MA, Damodaran T, et al. Insights into the neuropathology of cerebral ischemia and its mechanisms. Rev Neurosci. 2020;31(5):521–38. doi:10.1515/revneuro-2019-0099
  • Yi JH, Park SW, Kapadia R, Vemuganti R. Role of transcription factors in mediating post-ischemic cerebral inflammation and brain damage. Neurochem Int. 2007;50(1014-1027):1014–27.
  • Kuriakose D, Xiao Z. Pathophysiology and treatment of stroke: present status and future perspectives. Int J Mol Sci. 2020 Oct 15;21(20):7609. doi:10.3390/ijms21207609
  • Li TF, Ma J, Han XW, Jia YX, Yuan HF, Shui SF, et al. Chrysin ameliorates cerebral ischemia/reperfusion (I/R) injury in rats by regulating the PI3 K/Akt/mTOR pathway. Neurochem Int. 2019a;129:104496. doi:10.1016/j.neuint.2019.104496
  • Wang J, Mao J, Wang R, Li S, Wu B, Yuan Y. Kaempferol protects against cerebral ischemia reperfusion injury through intervening oxidative and inflammatory stress induced apoptosis. Front Pharmacol. 2020;11:424. doi:10.3389/fphar.2020.00424
  • Windle V, Szymanska A, Granter-Button S, White C, Buist R, Peeling J, et al. An analysis of four different methods of producing focal cerebral ischemia with endothelin-1 in the rat. Exp Neurol. 2006 Oct 1;201(2):324–34. doi:10.1016/j.expneurol.2006.04.012
  • Hung VK, Yeung PK, Lai AK, Ho MC, Lo AC, Chan KC, et al. Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion. J Cereb Blood Flow Metab. 2015 Oct;35(10):1687–96. doi:10.1038/jcbfm.2015.109
  • Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 4th ed. San Diego (CA): Academic Press; 1998.
  • Macrae IM, Robinson MJ, Graham DI, JL R, McCulloch J. Endothelin-1-induced reductions in cerebral blood flow: dose dependency, time course, and neuropathological consequences. J Cereb Blood Flow Metab. 1993 Mar;13(2):276–84. doi:10.1038/jcbfm.1993.34
  • Hughes PM, Anthony DC, Ruddin M, Botham MS, Rankine EL, Sablone M, et al. Focal lesions in the rat central nervous system induced by endothelin-1. J Neuropathol Exp Neurol. 2003 Dec 1;62(12):1276–86. doi:10.1093/jnen/62.12.1276
  • Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20(1):84–91. doi:10.1161/01.STR.20.1.84
  • Joshi CN, Jain SK, Murthy PSR. An optimized triphenyltetrazolium chloride method for identification of cerebral infarcts. Brain Res Protoc. 2004;13(1):11–7. doi:10.1016/j.brainresprot.2003.12.001
  • Liu D, Ji Q, Cheng Y, Liu M, Zhang B, Mei Q, et al. Cyclosporine A loaded brain targeting nanoparticle to treat cerebral ischemia/reperfusion injury in mice. J Nanobiotechnol. 2022 Dec;20(1):1–7. doi:10.1186/s12951-021-01184-w
  • Zhang C, Bruins ME, Yang ZQ, Liu ST, Rao PF. A new formula to calculate activity of superoxide dismutase in indirect assays. Anal Biochem. 2016 Jun 15;503:65–7. doi:10.1016/j.ab.2016.03.014
  • Kalinovic S, Stamm P, Oelze M, Daub S, Kröller-Schön S, Kvandova M, et al. Comparison of three methods for in vivo quantification of glutathione in tissues of hypertensive rats. Free Radical. 2021 Dec 2;55(11-12):1048–61. doi:10.1080/10715762.2021.2016735
  • Hadwan MH. Simple spectrophotometric assay for measuring catalase activity in biological tissues. BMC Biochem. 2018 Dec;19(1):1–8. doi:10.1186/s12858-018-0097-5
  • Pomierny-Chamioło L, Moniczewski A, Wydra K, Suder A, Filip M. Oxidative stress biomarkers in some rat brain structures and peripheral organs underwent cocaine. Neurotoxicity. 2013 Jan;23:92–102. doi:10.1007/s12640-012-9335-6
  • Lorentz K. Improved determination of serum calcium with 2-cresolphthalein complexone. Clin Chim Acta. 1982;126(3):327–34. doi:10.1016/0009-8981(82)90308-4
  • Kuang X, Du JR, Chen YS, Wang J, Wang YN. Protective effect of Z-ligustilide against amyloid beta-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains. Pharmacol Biochem Behav. 2009;92(4):635–41. doi:10.1016/j.pbb.2009.03.007. (n.d.).
  • Hao MQ, Xie LJ, Leng W, Xue RW. Trim47 is a critical regulator of cerebral ischemia-reperfusion injury through regulating apoptosis and inflammation. Biochem Biophys Res Commun. 2019;515(4):651–7. doi:10.1016/j.bbrc.2019.05.065
  • Pei H, Song X, Peng C, Tan Y, Li Y, Li X, et al. TNF-α inhibitor protects against myocardial ischemia/reperfusion injury via Notch1-mediated suppression of oxidative/nitrative stress. Free Radical Biol Med. 2015;82:114–21. doi:10.1016/j.freeradbiomed.2015.02.002
  • Zheng T, Jiang H, Jin R, Zhao Y, Bai Y, Xu H, et al. Ginsenoside Rg1 attenuates protein aggregation and inflammatory response following cerebral ischemia and reperfusion injury. Eur J Pharmacol. 2019;853:65–73. doi:10.1016/j.ejphar.2019.02.018.
  • Lambertsen KL, Biber K, Finsen B. Inflammatory cytokines in experimental and human stroke. J Cereb Blood Flow Metab. 2012;32(9):1677–98. doi:10.1038/jcbfm.2012.
  • Li WH, Cheng X, Yang YL, Liu M, Zhang SS, Wang YH, et al. Kaempferol attenuates neuroinflammation and blood brain barrier dysfunction to improve neurological deficits in cerebral ischemia/reperfusion rats. Brain Res. 2019b;1722:146361. doi:10.1016/j.brainres.2019.146361
  • Santhrani T, Ch M. Neuroprotective effect of alcoholic extract of Terminalia arjuna bark in experimental stroke induced rats. Recent Res Mod Med. 2012: 281–301.
  • Shah ZA, Gilani RA, Sharma P, Vohora SB. Cerebroprotective effect of Korean ginseng tea against global and focal models of ischemia in rats. J Ethnopharmacol. 2005;101(1-3):299–307. doi:10.1016/j.jep.2005.05.002
  • Beckman JS, Beckman TW, Chen J, Marshall PA, BA F. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 1990;87(4):1620–4. doi:10.1073/pnas.87.4.1620
  • Shivakumar BR, Kolluri SV, Ravindranath V. Glutathione and protein thiol homeostasis in brain during reperfusion after cerebral ischemia. J Pharmacol Exp Ther. 1995;274(3):1167–73.
  • Halliwell B. Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med. 1991;91(3):S14–S22. doi:10.1016/0002-9343(91)90279-7
  • Kawakami M, Okabe E. Superoxide anion radical-triggered Ca2 + release from cardiac sarcoplasmic reticulum through ryanodine receptor Ca2 + channel. Mol Pharmacol. 1998;53(3):497–503. doi:10.1124/mol.53.3.497
  • Delanty N, Dichter MA. Oxidative injury in the nervous system. Acta Neurol Scand. 1998;98(3):145–53. doi:10.1111/j.1600-0404.1998.tb07285.x
  • Jenner P. Oxidative damage in neurodegenerative disease. Lancet. 1994;344(8925):796–8. n.d. doi:10.1016/S0140-6736(94)92347-7

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.