Synthesis and Biological Evaluation of Novel Benzylidene Thiazolo Pyrimidin-3(5H)-One Derivatives

References

• E. Akbaş, F. Aslanoğlu, M. Sönmez, and B. Anıl, “Studies on Reactions of Pyrimidine Compounds: Synthesis and Reactions of 5-Benzoyl-4, 6-Diphenyl-1, 2, 3, 4-Tetrahydro-2-Thioxopyrimidine,” Phosphorus, Sulfur, and Silicon and the Related Elements 182, no. 7 (2007): 1589–1597. doi:10.1080/10426500701263554
   Web of Science ®Google Scholar
• A. W. Powell, “Revision of the Extended Hantzsch-Widman System of Nomenclature for Heteromonocycles,” Pure and Applied Chemistry 55, no. 2 (1983): 409–416. doi:10.1351/pac198855020409
   Web of Science ®Google Scholar
• N. Kerru, L. Gummidi, S. Maddila, K. K. Gangu, and S. B. Jonnalagadda, “A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications,” Molecules 25, no. 8 (2020): 1909. doi:10.3390/molecules25081909
   PubMed Web of Science ®Google Scholar
• M. Schnürch, and M. D. Mihovilovic, “Topics in Heterocyclic Chemistry,” in Metalation of Azines and Diazines, edited by P. C. Gros , Springer-Verlag Berlin Heidelberg, New York, Dordrecht, London, 1, (2013):20.
   Google Scholar
• Mohit Agarwal, Vikram Singh, Sachin Kumar Sharma, Piush Sharma, Md Yousuf Ansari, Surender Singh Jadav, Sabina Yasmin, Reddymasu Sreenivasulu, Mohd Zaheen Hassan, Vipin Saini, et al. “Design and Synthesis of New 2,5-Disubstituted-1,3,4-Oxadiazole Analogues as Anticancer Agents,” Medicinal Chemistry Research 25, no. 10 (2016) : 2289–2303. doi:10.1007/s00044-016-1672-1
   Web of Science ®Google Scholar
• D. Rudavath, R. Sreenivasulu, S. R. Pinapati, and R. R. Raju, “Synthesis and Antitumor Evaluation of Novel 5-Bromo Indole-Aryl Keto Hydrazide-Hydrazone Analogues,” Asian Journal of Chemistry 30, no. 6 (2018): 1201–1204. doi:10.14233/ajchem.2018.21114
   Google Scholar
• I. S. Murthy, R. Sreenivasulu, G. Alluraiah, and R. R. Raju, “Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Linked 1,2-Isoxazole-Imidazo[4,5-b]Pyridine Derivatives,” Russian Journal of General Chemistry 89, no. 8 (2019): 1718–1723. doi:10.1134/S1070363219080279
   Web of Science ®Google Scholar
• R. Dudhe, P. K. Sharma, P. Verma, and A. Chaudhary, “Pyrimidine as Anticancer Agent: A Review,” Advances in Science and Research. 2 (2011) : 10.
   Google Scholar
• R. M. Kumbhare, T. L. Dadmal, M. J. Ramaiah, K. S. V. Kishore, S. N. C. V. L. Pushpa Valli, S. K. Tiwari, K. Appalanaidu, Y. K. Rao, and M. P. Bhadra, “Synthesis and Anticancer Evaluation of Novel Triazole Linked N-(Pyrimidin-2-yl)Benzo[d]Thiazol-2-Amine Derivatives as Inhibitors of Cell Survival Proteins and Inducers of Apoptosis in MCF-7 Breast Cancer Cells,” Bioorganic & Medicinal Chemistry Letters 25, no. 3 (2015): 654–658. doi:10.1016/j.bmcl.2014.11.083
   PubMed Web of Science ®Google Scholar
• a- S. B. Patwari, S. M. Murali, and V. B. Jadhav, “Microwave-Assisted Synthesis, Antimicrobial, and Cytotoxicity Activity of N-Tert-Butyl-3-{[2-(Arylamino)Pyrimidin-4-yl]Amino} Benzenesulfonamides,” Journal of Heterocyclic Chemistry 55, no. 12 (2018): 2911–2918. doi:10.1002/jhet.3364
   Web of Science ®Google Scholar
• S. A. Rahaman, Y. Rajendra Pasad, P. Kumar, and B. Kumar, “Synthesis and anti-Histaminic Activity of Some Novel Pyrimidines,” Saudi Pharmaceutical Journal : SPJ : The Official Publication of the Saudi Pharmaceutical Society 17, no. 3 (2009): 255–258. doi:10.1016/j.jsps.2009.08.001
   PubMedGoogle Scholar
• R. B. Tenser, A. Gaydos, and K. A. Hay, “Inhibition of Herpes Simplex Virus Reactivation by Dipyridamole,” Antimicrobial Agents and Chemotherapy 45, no. 12 (2001): 3657–3659. doi:10.1128/AAC.45.12.3657-3659.2001
   PubMed Web of Science ®Google Scholar
• A. Barakat, M. S. Islam, A. M. Al-Majid, H. A. Ghabbour, S. Yousuf, M. Ashraf, N. N. Shaikh, M. I. Choudhary, R. Khalil, and Z. Ul-Haq, “Synthesis of Pyrimidine-2,4,6-Trione Derivatives: Anti-Oxidant, anti-Cancer, α-Glucosidase, β-Glucuronidase Inhibition and Their Molecular Docking Studies,” Bioorganic Chemistry 68 (2016) : 72–79. doi:10.1016/j.bioorg.2016.07.009
   PubMed Web of Science ®Google Scholar
• C. Lefebvre, E. Forcellini, S. Boutin, M. Cote, R. C. Gaudreault, P. Mathieu, P. Lague, and J. Paquin, “Synthesis of Novel Substituted Pyrimidine Derivatives Bearing a Sulfamide Group and Their in Vitro Cancer Growth Inhibition Activity,” Bioorganic & Medicinal Chemistry Letters 27, no. 2 (2017): 299–302. doi:10.1016/j.bmcl.2016.11.052
   PubMed Web of Science ®Google Scholar
• E. Akbas, S. Ekin, E. Ergan, and Y. Karakus, “Synthesis, DFT Calculations, Spectroscopy and in Vitro Antioxidant Activity Studies on 4-Hydroxyphenyl Substituted Thiopyrimidine Derivatives,” Journal of Molecular Structure 1174 (2018) : 177–183. doi:10.1016/j.molstruc.2018.02.080
   Web of Science ®Google Scholar
• E. Akbas, A. Ruzgar, E. Sahin, and E. Ergan, “A Green Protocol for Simple One-Pot Synthesis of New Pyrimidine Derivatives Both Microwave Irradiation and Conventional Heating:Reactions, Characterization, and Theoretical Calculations,” Journal of Heterocyclic Chemistry 56, no. 3 (2019): 1003–1011. doi:10.1002/jhet.3483
   Web of Science ®Google Scholar
• E. Akbas, S. Çelik, E. Ergan, and A. Levent, “Synthesis, Characterization, Quantum Chemical Studies and Electrochemical Performance of New 4,7-Dihydrotetrazolo[1,5-a]Pyrimidine Derivatives,” Journal of Chemical Sciences 131, no. 4 (2019): 30. doi:10.1007/s12039-019-1602-0
   Web of Science ®Google Scholar
• A. Contini, E. Erba, and P. Trimarco, “Synthesis of 4-Nitromethylene-1,4-Dihydropyrimidine Derivatives as Pyrimidine Nucleoside Analogues,” Tetrahedron 64, no. 49 (2008): 11067–11073. doi:10.1016/j.tet.2008.09.079
   Web of Science ®Google Scholar
• A. D. Becke, “Density‐Functional Thermochemistry. I. The Effect of the Exchange‐Only Gradient Correction,” The Journal of Chemical Physics 96, no. 3 (1992): 2155–2160. doi:10.1063/1.462066
   Web of Science ®Google Scholar
• A. D. Becke, “Density‐Functional Thermochemistry. III. The Role of Exact Exchange,” The Journal of Chemical Physics 98, no. 2 (1993): 1372–1377. doi:10.1063/1.464304
   Web of Science ®Google Scholar
• C. Lee, W. Yang, and R. G. Parr, “Development of the Colle-Salvetti Correlation-Energy Formula into a Functional of the Electron Density,” Physical Review. B, Condensed Matter 1537, no. 2 (1988) : 785–789. doi:10.1103/physrevb.37.785
   PubMed Web of Science ®Google Scholar
• A. Frisch, Gaussian 09W Reference: Gaussian, Inc., USA, (2009).
   Google Scholar
• E. Akbas, A. Erdogan, E. Ergan, and A. Ruzgar, “Synthesis, DFT Study and the Eschenmoser Sulfide Contraction of 1,2,3,4-Tetrahydropyrimidine Derivatives,” Journal of the Chemical Society of Pakistan. 39 (2017): 269.
   Web of Science ®Google Scholar
• H. Wang, X. Wang, H. Wang, L. Wang, and A. Liu, “DFT Study of New Bipyrazole Derivatives and Their Potential Activity as Corrosion Inhibitors,” Journal of Molecular Modeling 13, no. 1 (2007): 147–153. doi:10.1007/s00894-006-0135-x
   PubMed Web of Science ®Google Scholar
• H. J. Evans, and M. L. O'Riordan, “Human Peripheral Blood Lymphocytes for the Analysis of Chromosome Aberrations in Mutagen Tests,” Mutation Research 31, no. 3 (1975): 135–148. doi:10.1016/0165-1161(75)90082-5
   PubMedGoogle Scholar
• H. Turkez, M. I. Yousef, E. Sönmez, B. Togar, F. Bakan, P. Sozio, and A. D. Stefano, “Evaluation of Cytotoxic, Oxidative Stress and Genotoxic Responses of Hydroxyapatite Nanoparticles on Human Blood Cells,” Journal of Applied Toxicology : JAT 34, no. 4 (2014): 373–379. doi:10.1002/jat.2958
   PubMed Web of Science ®Google Scholar
• B. Emsen, A. Aslan, B. Togar, and H. Turkez, “In Vitro Antitumor Activities of the Lichen Compounds Olivetoric, Physodic and Psoromic Acid in Rat Neuron and Glioblastoma Cells,” Pharmaceutical Biology 54, no. 9 (2016): 1748–1762. doi:10.3109/13880209.2015.1126620
   PubMed Web of Science ®Google Scholar
• M. Fenech, “The Cytokinesis-Block Micronucleus Technique: A Detailed Description of the Method and Its Application to Genotoxicity Studies in Human Populations,” Mutation Research 285, no. 1 (1993): 35–44. doi:10.1016/0027-5107(93)90049-l
   PubMed Web of Science ®Google Scholar
• T. Arabaci, H. Türkez, C. F. Çanakçi, and M. Özgöz, “Assessment of Cytogenetic and Cytotoxic Effects of Chlorhexidine Digluconate on Cultured Human Lymphocytes,” Acta Odontologica Scandinavica 71, no. 5 (2013): 1255–1260. doi:10.3109/00016357.2012.757646
   PubMed Web of Science ®Google Scholar
• H. Turkez, I. Cacciatore, M. E. Arslan, E. Fornasari, L. Marinelli, A. Di Stefano, and A. Mardinoglu, “Histidyl-Proline Diketopiperazine Isomers as Multipotent anti-Alzheimer Drug Candidates,” Biomolecules 10, no. 5 (2020): 737. doi:10.3390/biom10050737
   PubMed Web of Science ®Google Scholar