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Review Article

Advancements in Biosensors for Point-of-Care Testing of Nucleic Acid

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References

  • Jones, I.; Roy, P. Sputnik V COVID-19 Vaccine Candidate Appears Safe and Effective. Lancet 2021, 397, 642–643. DOI: 10.1016/S0140-6736(21)00191-4.
  • Coskun, A. F.; Cetin, A. E.; Galarreta, B. C.; Alvarez, D. A.; Altug, H.; Ozcan, A. Lensfree Optofluidic Plasmonic Sensor for Real-Time and Label-Free Monitoring of Molecular Binding Events over a Wide Field-of-View. Sci. Rep. 2014, 4, 6789. DOI: 10.1038/srep06789.
  • Guo, J. Smartphone-Powered Electrochemical Dongle for Point-of-Care Monitoring of Blood β-Ketone. Anal. Chem. 2017, 89, 8609–8613. DOI: 10.1021/acs.analchem.7b02531.
  • Priye, A.; Wong, S.; Bi, Y.; Carpio, M.; Chang, J.; Coen, M.; Cope, D.; Harris, J.; Johnson, J.; Keller, A.; et al. Lab-on-a-Drone: Toward Pinpoint Deployment of Smartphone-Enabled Nucleic Acid-Based Diagnostics for Mobile Health Care. Anal. Chem. 2016, 88, 4651–4660. DOI: 10.1021/acs.analchem.5b04153.
  • Shang, Y.; Xing, G.; Liu, X.; Lin, H.; Lin, J.-M. Fully Integrated Microfluidic Biosensor with Finger Actuation for the Ultrasensitive Detection of Escherichia coli O157:H7. Anal. Chem. 2022, 94, 16787–16795. DOI: 10.1021/acs.analchem.2c03686.
  • Nguyen, H. V.; Nguyen, V. D.; Nguyen, H. Q.; Chau, T. H. T.; Lee, E. Y.; Seo, T. S. Nucleic Acid Diagnostics on the Total Integrated Lab-on-a-Disc for Point-of-Care Testing. Biosens. Bioelectron. 2019, 141, 111466. DOI: 10.1016/j.bios.2019.111466.
  • Okunade, K. S. Human Papillomavirus and Cervical Cancer. Journal of Obstetrics and Gynaecology 2020, 40, 602–608. DOI: 10.1080/01443615.2019.1634030.
  • Gnanamony, M.; Peedicayil, A.; Subhashini, J.; Ram, T. S.; Rajasekar, A.; Gravitt, P.; Abraham, P. Detection and Quantitation of HPV 16 and 18 in Plasma of Indian Women with Cervical Cancer. Gynecol. Oncol. 2010, 116, 447–451. DOI: 10.1016/j.ygyno.2009.10.081.
  • Kay, P.; Allan, B.; Denny, L.; Hoffman, M.; Williamson, A.-L. Detection of HPV 16 and HPV 18 DNA in the Blood of Patients with Cervical Cancer. J. Med. Virol. 2005, 75, 435–439. DOI: 10.1002/jmv.20294.
  • Das, J.; Ivanov, I.; Montermini, L.; Rak, J.; Sargent, E. H.; Kelley, S. O. An Electrochemical Clamp Assay for Direct, Rapid Analysis of Circulating Nucleic Acids in Serum. Nat. Chem. 2015, 7, 569–575. DOI: 10.1038/nchem.2270.
  • Guarnaccia, M.; Iemmolo, R.; Petralia, S.; Conoci, S.; Cavallaro, S. Miniaturized Real-Time PCR on a Q3 System for Rapid KRAS Genotyping. Sensors (Basel) 2017, 17, 831. DOI: 10.3390/s17040831.
  • Drain, P. K.; Hyle, E. P.; Noubary, F.; Freedberg, K. A.; Wilson, D.; Bishai, W. R.; Rodriguez, W.; Bassett, I. V. Diagnostic Point-of-Care Tests in Resource-Limited Settings. Lancet Infect. Dis. 2014, 14, 239–249. DOI: 10.1016/S1473-3099(13)70250-0.
  • Eltzov, E.; Guttel, S.; Low Yuen Kei, A.; Sinawang, P. D.; Ionescu, R. E.; Marks, R. S. Lateral Flow Immunoassays – from Paper Strip to Smartphone Technology. Electroanalysis 2015, 27, 2116–2130. DOI: 10.1002/elan.201500237.
  • Erensoy, S. [SARS-CoV-2 and Microbiological Diagnostic Dynamics in COVID-19 Pandemic]. Mikrobiyol. Bul. 2020, 54, 497–509. DOI: 10.5578/mb.69839.
  • Fang, J.; Qiu, X.; Wan, Z.; Zou, Q.; Su, K.; Hu, N.; Wang, P. A Sensing Smartphone and Its Portable Accessory for on-Site Rapid Biochemical Detection of Marine Toxins. Anal. Methods 2016, 8, 6895–6902. DOI: 10.1039/C6AY01384H.
  • Focke, M.; Stumpf, F.; Roth, G.; Zengerle, R.; von Stetten, F. Centrifugal Microfluidic System for Primary Amplification and Secondary Real-Time PCR. Lab Chip. 2010, 10, 3210–3212. DOI: 10.1039/c0lc00161a.
  • Reboud, J.; Xu, G.; Garrett, A.; Adriko, M.; Yang, Z.; Tukahebwa, E. M.; Rowell, C.; Cooper, J. M. Paper-Based Microfluidics for DNA Diagnostics of Malaria in Low Resource Underserved Rural Communities. Proc. Natl. Acad. Sci. USA. 2019, 116, 4834–4842. DOI: 10.1073/pnas.1812296116.
  • Fu, Y.; Wen, S.; Ma, L. 2017 Data Adaptively Storing Approach for Hadoop Distributed File System. In 2017 2nd IEEE International Conference on Computational Intelligence and Applications (ICCIA), 20. DOI: 10.1109/CIAPP.2017.8167053.
  • Wade, J. H.; Bailey, R. C. Applications of Optical Microcavity Resonators in Analytical Chemistry. Annual Rev. Anal. Chem. 2016, 9, 1–25. DOI: 10.1146/annurev-anchem-071015-041742.
  • Wang, J.; Zhou, H. S. Aptamer-Based Au Nanoparticles-Enhanced Surface Plasmon Resonance Detection of Small Molecules. Anal. Chem. 2008, 80, 7174–7178. DOI: 10.1021/ac801281c.
  • Weber, J. A.; Baxter, D. H.; Zhang, S.; Huang, D. Y.; How Huang, K.; Jen Lee, M.; Galas, D. J.; Wang, K. The MicroRNA Spectrum in 12 Body Fluids. Clin. Chem. 2010, 56, 1733–1741. DOI: 10.1373/clinchem.2010.147405.
  • Roth Gregory, A.; Mensah George, A.; Johnson Catherine, O.; Addolorato, G.; Ammirati, E.; Baddour Larry, M.; Barengo Noël, C.; Beaton Andrea, Z.; Benjamin Emelia, J.; Benziger Catherine, P.; et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019. J. Am. Coll. Cardiol. 2020, 76, 2982–3021. DOI: 10.1016/j.jacc.2020.11.010.
  • Zhang, L.; Mei, L.; Wang, K.; Lv, Y.; Zhang, S.; Lian, Y.; Liu, X.; Ma, Z.; Xiao, G.; Liu, Q.; et al. Advances in the Application of Perovskite Materials. Nanomicro. Lett. 2023, 15, 177. DOI: 10.1007/s40820-023-01140-3.
  • Bogoch, I. I.; Koydemir, H. C.; Tseng, D.; Ephraim, R. K. D.; Duah, E.; Tee, J.; Andrews, J. R.; Ozcan, A. Evaluation of a Mobile Phone-Based Microscope for Screening of Schistosoma haematobium Infection in Rural Ghana. Am. Soc. Trop. Med. Hygiene 2017, 96, 1468–1471. DOI: 10.4269/ajtmh.16-0912.
  • Brassard, D.; Geissler, M.; Descarreaux, M.; Tremblay, D.; Daoud, J.; Clime, L.; Mounier, M.; Charlebois, D.; Veres, T. Extraction of Nucleic Acids from Blood: Unveiling the Potential of Active Pneumatic Pumping in Centrifugal Microfluidics for Integration and Automation of Sample Preparation Processes. Lab Chip. 2019, 19, 1941–1952. DOI: 10.1039/c9lc00276f.
  • Breaker, R. R.; Joyce, G. F. A DNA Enzyme That Cleaves RNA. Chem. Biol. 1994, 1, 223–229. DOI: 10.1016/1074-5521(94)90014-0.
  • Brown, R. A. M.; Epis, M. R.; Horsham, J. L.; Kabir, T. D.; Richardson, K. L.; Leedman, P. J. Total RNA Extraction from Tissues for microRNA and Target Gene Expression Analysis: Not All Kits Are Created Equal. BMC Biotechnol. 2018, 18, 16. DOI: 10.1186/s12896-018-0421-6.
  • Cate, D. M.; Dungchai, W.; Cunningham, J. C.; Volckens, J.; Henry, C. S. Simple, Distance-Based Measurement for Paper Analytical Devices. Lab Chip. 2013, 13, 2397–2404. DOI: 10.1039/c3lc50072a.
  • Chaumpluk, P.; Plubcharoensook, P.; Prasongsuk, S. Rapid Detection of Aflatoxigenic Aspergillus sp. in Herbal Specimens by a Simple, Bendable, Paper-Based Lab-on-a-Chip. Biotechnol. J. 2016, 11, 768–779. DOI: 10.1002/biot.201500435.
  • Chiu, R. Y. T.; Thach, A. V.; Wu, C. M.; Wu, B. M.; Kamei, D. T. An Aqueous Two-Phase System for the Concentration and Extraction of Proteins from the Interface for Detection Using the Lateral-Flow Immunoassay. PLoS One. 2015, 10, e0142654. DOI: 10.1371/journal.pone.0142654.
  • Choi, G.; Jung, J. H.; Park, B. H.; Oh, S. J.; Seo, J. H.; Choi, J. S.; Kim, D. H.; Seo, T. S. A Centrifugal Direct Recombinase Polymerase Amplification (direct-RPA) Microdevice for Multiplex and Real-Time Identification of Food Poisoning Bacteria. Lab Chip. 2016, 16, 2309–2316. DOI: 10.1039/c6lc00329j.
  • Conzuelo, F.; Gamella, M.; Campuzano, S.; Pinacho, D. G.; Reviejo, A. J.; Marco, M. P.; Pingarrón, J. M. Disposable and Integrated Amperometric Immunosensor for Direct Determination of Sulfonamide Antibiotics in Milk. Biosens. Bioelectron. 2012, 36, 81–88. DOI: 10.1016/j.bios.2012.03.044.
  • Craw, P.; Balachandran, W. Isothermal Nucleic Acid Amplification Technologies for Point-of-Care Diagnostics: A Critical Review. Lab Chip. 2012, 12, 2469–2486. DOI: 10.1039/c2lc40100b.
  • Dou, J.; Shen, Q.; Yang, Y.; Song, H.; Shen, D. A Smartphone-Based Device for Simultaneous Measurement of Ratiometric Fluorescence and Absorbance Demonstrated by the Determination of Hypochlorous Acid. New J. Chem. 2022, 46, 17487–17495. DOI: 10.1039/D2NJ03106J.
  • Rashidnia, A.; Pakarzadeh, H.; Hatami, M.; Ayyanar, N. Photonic Crystal-Based Biosensor for Detection of Human Red Blood Cells Parasitized by Plasmodium falciparum. Opt. Quant. Electron. 2021, 54, 38. DOI: 10.1007/s11082-021-03421-w.
  • Hao, K.; He, Y.; Lu, H.; Pu, S.; Zhang, Y.; Dong, H.; Zhang, X. High-Sensitive Surface Plasmon Resonance microRNA Biosensor Based on Streptavidin Functionalized Gold Nanorods-Assisted Signal Amplification. Anal. Chim. Acta. 2017, 954, 114–120. DOI: 10.1016/j.aca.2016.12.006.
  • Zheng, X.; Wang, Y.; Bu, S.; Chen, Z.; Wan, J. Point-of-Care Detection of 16S rRNA of Staphylococcus aureus Based on Multiple Biotin-Labeled DNA Probes. Mol. Cell. Probes. 2019, 47, 101427. DOI: 10.1016/j.mcp.2019.101427.
  • Bahl, S.; Bagha, A. K.; Rab, S.; Javaid, M.; Haleem, A.; Singh, R. P. Advancements in Biosensor Technologies for Medical Field and COVID-19 Pandemic. J. Ind. Intg. Mgmt. 2021, 06, 175–191. DOI: 10.1142/S2424862221500081.
  • Guo, L.; Sun, X.; Wang, X.; Liang, C.; Jiang, H.; Gao, Q.; Dai, M.; Qu, B.; Fang, S.; Mao, Y.; et al. SARS-CoV-2 Detection with CRISPR Diagnostics. Cell Discov. 2020, 6, 34. DOI: 10.1038/s41421-020-0174-y.
  • Kovács, A.; Palásti, P.; Veréb, D.; Bozsik, B.; Palkó, A.; Kincses, Z. T. The Sensitivity and Specificity of Chest CT in the Diagnosis of COVID-19. Eur. Radiol. 2021, 31, 2819–2824. DOI: 10.1007/s00330-020-07347-x.
  • Knowlton, S.; Joshi, A.; Syrrist, P.; Coskun, A. F.; Tasoglu, S. 3D-Printed Smartphone-Based Point of Care Tool for Fluorescence- and Magnetophoresis-Based Cytometry. Lab Chip. 2017, 17, 2839–2851. DOI: 10.1039/c7lc00706j.
  • Abdukayum, A.; Yang, C.-X.; Zhao, Q.; Chen, J.-T.; Dong, L.-X.; Yan, X.-P. Gadolinium Complexes Functionalized Persistent Luminescent Nanoparticles as a Multimodal Probe for near-Infrared Luminescence and Magnetic Resonance Imaging in Vivo. Anal. Chem. 2014, 86, 4096–4101. DOI: 10.1021/ac500644x.
  • Antillon, M.; Saad, N. J.; Baker, S.; Pollard, A. J.; Pitzer, V. E. The Relationship between Blood Sample Volume and Diagnostic Sensitivity of Blood Culture for Typhoid and Paratyphoid Fever: A Systematic Review and Meta-Analysis. J. Infect. Dis. 2018, 218, S255–S267. DOI: 10.1093/infdis/jiy471.
  • Arts, R.; den Hartog, I.; Zijlema, S. E.; Thijssen, V.; van der Beelen, S. H. E.; Merkx, M. Detection of Antibodies in Blood Plasma Using Bioluminescent Sensor Proteins and a Smartphone. Anal. Chem. 2016, 88, 4525–4532. DOI: 10.1021/acs.analchem.6b00534.
  • Aviñó, A.; Huertas, C. S.; Lechuga, L. M.; Eritja, R. Sensitive and Label-Free Detection of miRNA-145 by Triplex Formation. Anal. Bioanal. Chem. 2016, 408, 885–893. DOI: 10.1007/s00216-015-9180-6.
  • Bagherbaigi, S.; Córcoles, E. P.; Wicaksono, D. H. B. Cotton Fabric as an Immobilization Matrix for Low-Cost and Quick Colorimetric Enzyme-Linked Immunosorbent Assay (ELISA). Anal. Methods 2014, 6, 7175.
  • Saki, E. F.; Setiawan, S. A.; Wicaksono, D. H. B. Portable Tools for COVID-19 Point-of-Care Detection: A Review. IEEE Sens. J. 2021, 21, 23737–23750. DOI: 10.1109/JSEN.2021.3110857.
  • Yoo, E.-H.; Lee, S.-Y. Glucose Biosensors: An Overview of Use in Clinical Practice. in. Sensors 2010, 10, 4558–4576. DOI: 10.3390/s100504558.
  • Ngo, H. T.; Freedman, E.; Odion, R. A.; Strobbia, P.; De Silva Indrasekara, A. S.; Vohra, P.; Taylor, S. M.; Vo-Dinh, T. Direct Detection of Unamplified Pathogen RNA in Blood Lysate Using an Integrated Lab-in-a-Stick Device and Ultrabright SERS Nanorattles. Sci. Rep. 2018, 8, 4075. DOI: 10.1038/s41598-018-21615-3.
  • Li, F.; Dong, Y.; Zhang, Z.; Lv, M.; Wang, Z.; Ruan, X.; Yang, D. A Recyclable Biointerface Based on Cross-Linked Branched DNA Nanostructures for Ultrasensitive Nucleic Acid Detection. Biosens. Bioelectron. 2018, 117, 562–566. DOI: 10.1016/j.bios.2018.06.053.
  • Kurita, R.; Yanagisawa, H.; Yoshioka, K.; Niwa, O. On-Chip Sequence-Specific Immunochemical Epigenomic Analysis Utilizing Outward-Turned Cytosine in a DNA Bulge with Handheld Surface Plasmon Resonance Equipment. Anal. Chem. 2015, 87, 11581–11586. DOI: 10.1021/acs.analchem.5b03520.
  • Ming, T.; Cheng, Y.; Xing, Y.; Luo, J.; Mao, G.; Liu, J.; Sun, S.; Kong, F.; Jin, H.; Cai, X. Electrochemical Microfluidic Paper-Based Aptasensor Platform Based on a Biotin–Streptavidin System for Label-Free Detection of Biomarkers. ACS Appl. Mater. Interfaces. 2021, 13, 46317–46324. DOI: 10.1021/acsami.1c12716.
  • Ming, T.; Lan, T.; Yu, M.; Wang, H.; Deng, J.; Kong, D.; Yang, S.; Shen, Z. Platinum Black/Gold Nanoparticles/Polyaniline Modified Electrochemical Microneedle Sensors for Continuous in Vivo Monitoring of pH Value. Polymers (Basel) 2023, 15, 2796. DOI: 10.3390/polym15132796.
  • Ming, T.; Luo, J.; Xing, Y.; Cheng, Y.; Liu, J.; Sun, S.; Kong, F.; Xu, S.; Dai, Y.; Xie, J.; et al. Recent Progress and Perspectives of Continuous in Vivo Testing Device. Mater. Today Bio 2022, 16, 100341. DOI: 10.1016/j.mtbio.2022.100341.
  • Mei, L.; Zhang, K.; Cui, N.; Yu, W.; Li, Y.; Gong, K.; Li, H.; Fu, N.; Yuan, J.; Mu, H.; et al. Ultraviolet-Visible-Short-Wavelength Infrared Broadband and Fast-Response Photodetectors Enabled by Individual Monocrystalline Perovskite Nanoplate. Small 2023, 19, e2301386. DOI: 10.1002/smll.202301386.
  • Lan, H.; Zou, Y.; Huang, Z.; Wang, J.; Gou, L.; Liao, X.; Pu, X.; Fang, Y.; Li, D.; Wu, J.; Yin, G. Rapid Detection of Two Markers of Acute Aortic Dissection Based on a Lateral Flow Assay of Hollow CdTe/CdS Nanospheres. Colloids Surf, A 2023, 667, 131353. DOI: 10.1016/j.colsurfa.2023.131353.
  • Ming, T.; Wang, Y.; Luo, J.; Liu, J.; Sun, S.; Xing, Y.; Xiao, G.; Jin, H.; Cai, X. Folding Paper-Based Aptasensor Platform Coated with Novel Nanoassemblies for Instant and Highly Sensitive Detection of 17β-Estradiol. ACS Sens. 2019, 4, 3186–3194. DOI: 10.1021/acssensors.9b01633.
  • Mao, X.; Ma, Y.; Zhang, A.; Zhang, L.; Zeng, L.; Liu, G. Disposable Nucleic Acid Biosensors Based on Gold Nanoparticle Probes and Lateral Flow Strip. Anal. Chem. 2009, 81, 1660–1668. DOI: 10.1021/ac8024653.
  • Mitchell, P. S.; Parkin, R. K.; Kroh, E. M.; Fritz, B. R.; Wyman, S. K.; Pogosova-Agadjanyan, E. L.; Peterson, A.; Noteboom, J.; O'Briant, K. C.; Allen, A.; et al. Circulating microRNAs as Stable Blood-Based Markers for Cancer Detection. Proc. Natl. Acad. Sci. USA. 2008, 105, 10513–10518. DOI: 10.1073/pnas.0804549105.
  • Nayak, S.; Blumenfeld, N. R.; Laksanasopin, T.; Sia, S. K. Point-of-Care Diagnostics: Recent Developments in a Connected Age. Anal. Chem. 2017, 89, 102–123. DOI: 10.1021/acs.analchem.6b04630.
  • Peiris, J. S. M.; Guan, Y.; Yuen, K. Y. Severe Acute Respiratory Syndrome. Nat. Med. 2004, 10, S88–S97. DOI: 10.1038/nm1143.
  • Melzak, K. A.; Sherwood, C. S.; Turner, R. F. B.; Haynes, C. A. Driving Forces for DNA Adsorption to Silica in Perchlorate Solutions. J. Colloid Interface Sci. 1996, 181, 635–644. DOI: 10.1006/jcis.1996.0421.
  • Park, J.; Shin, J. H.; Park, J.-K. Pressed Paper-Based Dipstick for Detection of Foodborne Pathogens with Multistep Reactions. Anal. Chem. 2016, 88, 3781–3788. DOI: 10.1021/acs.analchem.5b04743.
  • Rapisarda, A.; Giamblanco, N.; Marletta, G. Kinetic Discrimination of DNA Single-Base Mutations by Localized Surface Plasmon Resonance. J. Colloid Interface Sci. 2017, 487, 141–148. DOI: 10.1016/j.jcis.2016.10.026.
  • Ratajczak, K.; Stobiecka, M. High-Performance Modified Cellulose Paper-Based Biosensors for Medical Diagnostics and Early Cancer Screening: A Concise Review. Carbohydr. Polym. 2020, 229, 115463. DOI: 10.1016/j.carbpol.2019.115463.
  • Martinez, A. W.; Phillips, S. T.; Carrilho, E.; Thomas, S. W., III, Sindi, H.; Whitesides, G. M. Simple Telemedicine for Developing Regions: Camera Phones and Paper-Based Microfluidic Devices for Real-Time, off-Site Diagnosis. Anal. Chem. 2008, 80, 3699–3707. DOI: 10.1021/ac800112r.
  • Shekhar, S.; Kumar, R.; Rai, N.; Kumar, V.; Singh, K.; Upadhyay, A. D.; Tripathi, M.; Dwivedi, S.; Dey, A. B.; Dey, S. Estimation of Tau and Phosphorylated Tau181 in Serum of Alzheimer’s Disease and Mild Cognitive Impairment Patients. PLoS One. 2016, 11, e0159099. DOI: 10.1371/journal.pone.0159099.
  • Shen, M.; Zhou, Y.; Ye, J.; Abdullah Al-Maskri, A. A.; Kang, Y.; Zeng, S.; Cai, S. Recent Advances and Perspectives of Nucleic Acid Detection for Coronavirus. J. Pharm. Anal. 2020, 10, 97–101. DOI: 10.1016/j.jpha.2020.02.010.
  • Siravegna, G.; Marsoni, S.; Siena, S.; Bardelli, A. Integrating Liquid Biopsies into the Management of Cancer. Nat. Rev. Clin. Oncol. 2017, 14, 531–548. DOI: 10.1038/nrclinonc.2017.14.
  • Soh, J. H.; Chan, H.-M.; Ying, J. Y. Strategies for Developing Sensitive and Specific Nanoparticle-Based Lateral Flow Assays as Point-of-Care Diagnostic Device. Nano Today 2020, 30, 100831. DOI: 10.1016/j.nantod.2019.100831.
  • Stumpf, F.; Schwemmer, F.; Hutzenlaub, T.; Baumann, D.; Strohmeier, O.; Dingemanns, G.; Simons, G.; Sager, C.; Plobner, L.; von Stetten, F.; et al. LabDisk with Complete Reagent Prestorage for Sample-to-Answer Nucleic Acid Based Detection of Respiratory Pathogens Verified with Influenza a H3N2 Virus. Lab Chip. 2016, 16, 199–207. DOI: 10.1039/c5lc00871a.
  • Udugama, B.; Kadhiresan, P.; Kozlowski, H. N.; Malekjahani, A.; Osborne, M.; Li, V. Y. C.; Chen, H.; Mubareka, S.; Gubbay, J. B.; Chan, W. C. W. Diagnosing COVID-19: The Disease and Tools for Detection. ACS Nano. 2020, 14, 3822–3835. DOI: 10.1021/acsnano.0c02624.
  • Villarroya-Beltri, C.; Gutiérrez-Vázquez, C.; Sánchez-Cabo, F.; Pérez-Hernández, D.; Vázquez, J.; Martin-Cofreces, N.; Martinez-Herrera, D. J.; Pascual-Montano, A.; Mittelbrunn, M.; Sánchez-Madrid, F. Sumoylated hnRNPA2B1 Controls the Sorting of miRNAs into Exosomes through Binding to Specific Motifs. Nat. Commun. 2013, 4, 2980. DOI: 10.1038/ncomms3980.
  • You, M.; Li, Z.; Feng, S.; Gao, B.; Yao, C.; Hu, J.; Xu, F. Ultrafast Photonic PCR Based on Photothermal Nanomaterials. Trends Biotechnol. 2020, 38, 637–649. DOI: 10.1016/j.tibtech.2019.12.006.
  • Welch, N. G.; Scoble, J. A.; Muir, B. W.; Pigram, P. J. Orientation and Characterization of Immobilized Antibodies for Improved Immunoassays (Review). Biointerphases 2017, 12, 02D301. DOI: 10.1116/1.4978435.
  • Weston, M.; Geng, S.; Chandrawati, R. Food Sensors: Challenges and Opportunities. Adv. Mater. Technol. 2021, 6, 2001242. DOI: 10.1002/admt.202001242.
  • Zhang, Y.; Nguyen, N.-T. Magnetic Digital Microfluidics – A Review. Lab Chip. 2017, 17, 994–1008. DOI: 10.1039/c7lc00025a.
  • Eksin, E.; Erdem, A. Recent Progress on Optical Biosensors Developed for Nucleic Acid Detection Related to Infectious Viral Diseases. Micromachines. (Basel) 2023, 14, 295. DOI: 10.3390/mi14020295.
  • Yang, T.; Luo, Z.; Tian, Y.; Qian, C.; Duan, Y. Design Strategies of AuNPs-Based Nucleic Acid Colorimetric Biosensors. TrAC, Trends Anal. Chem. 2020, 124, 115795. DOI: 10.1016/j.trac.2019.115795.
  • Zhou, W.; Gao, X.; Liu, D.; Chen, X. Gold Nanoparticles for in Vitro Diagnostics. Chem. Rev. 2015, 115, 10575–10636. DOI: 10.1021/acs.chemrev.5b00100.
  • Ma, X.-M.; Sun, M.; Lin, Y.; Liu, Y.-J.; Luo, F.; Guo, L.-H.; Qiu, B.; Lin, Z.-Y.; Chen, G.-N. Progress of Visual Biosensor Based on Gold Nanoparticles. Chin. J. Anal. Chem. 2018, 46, 1–10. DOI: 10.1016/S1872-2040(17)61061-2.
  • Chauhan, V. M.; Elsutohy, M. M.; McClure, C. P.; Irving, W. L.; Roddis, N.; Aylott, J. W. Gold–Oligonucleotide Nanoconstructs Engineered to Detect Conserved Enteroviral Nucleic Acid Sequences. in. Biosensors (Basel) 2021, 11, 238. DOI: 10.3390/bios11070238.
  • Li, K.; Luo, Y.; Huang, K.; Yang, Z.; Wan, Y.; Xu, W. Single Universal Primer Recombinase Polymerase Amplification-Based Lateral Flow Biosensor (SUP-RPA-LFB) for Multiplex Detection of Genetically Modified Maize. Anal. Chim. Acta. 2020, 1127, 217–224. DOI: 10.1016/j.aca.2020.06.001.
  • Rivas, L.; Reuterswärd, P.; Rasti, R.; Herrmann, B.; Mårtensson, A.; Alfvén, T.; Gantelius, J.; Andersson-Svahn, H. A Vertical Flow Paper-Microarray Assay with Isothermal DNA Amplification for Detection of Neisseria meningitidis. Talanta 2018, 183, 192–200. DOI: 10.1016/j.talanta.2018.02.070.
  • Alafeef, M.; Moitra, P.; Dighe, K.; Pan, D. RNA-Extraction-Free Nano-Amplified Colorimetric Test for Point-of-Care Clinical Diagnosis of COVID-19. Nat. Protoc. 2021, 16, 3141–3162. DOI: 10.1038/s41596-021-00546-w.
  • Aydın, H. B.; Cheema, J. A.; Ammanath, G.; Toklucu, C.; Yucel, M.; Özenler, S.; Palaniappan, A.; Liedberg, B.; Yildiz, U. H. Pixelated Colorimetric Nucleic Acid Assay. Talanta 2020, 209, 120581. DOI: 10.1016/j.talanta.2019.120581.
  • Xu, X.; Wang, X.; Hu, J.; Gong, Y.; Wang, L.; Zhou, W.; Li, X.; Xu, F. A Smartphone-Based on-Site Nucleic Acid Testing Platform at Point-of-Care Settings. Electrophoresis 2019, 40, 914–921. DOI: 10.1002/elps.201800449.
  • Luo, Z.; Li, Y.; Zhang, P.; He, L.; Feng, Y.; Feng, Y.; Qian, C.; Tian, Y.; Duan, Y. Catalytic Hairpin Assembly as Cascade Nucleic Acid Circuits for Fluorescent Biosensor: Design, Evolution and Application. TrAC, Trends Anal. Chem. 2022, 151, 116582. DOI: 10.1016/j.trac.2022.116582.
  • Luo, J.; Xu, Y.; Huang, J.; Zhang, S.; Xu, Q.; He, J. Enzyme-Free Amplified Detection of Circulating microRNA by Making Use of DNA Circuits, a DNAzyme, and a Catalytic Hairpin Assembly. Microchim. Acta 2017, 185, 38. DOI: 10.1007/s00604-017-2565-9.
  • Wang, G.; Fu, Y.; Ren, Z.; Huang, J.; Best, S.; Li, X.; Han, G. Upconversion Nanocrystal ‘Armoured’ Silica Fibres with Superior Photoluminescence for miRNA Detection. Chem. Commun. 2018, 54, 6324–6327. DOI: 10.1039/C8CC03480J.
  • López-Valls, M.; Escalona-Noguero, C.; Rodríguez-Díaz, C.; Pardo, D.; Castellanos, M.; Milán-Rois, P.; Martínez-Garay, C.; Coloma, R.; Abreu, M.; Cantón, R.; et al. Cascade: Naked Eye-Detection of SARS-CoV-2 Using Cas13a and Gold Nanoparticles. Anal. Chim. Acta. 2022, 1205, 339749. DOI: 10.1016/j.aca.2022.339749.
  • Keyvani, F.; Debnath, N.; Ayman Saleh, M.; Poudineh, M. An Integrated Microfluidic Electrochemical Assay for Cervical Cancer Detection at Point-of-Care Testing. Nanoscale 2022, 14, 6761–6770. DOI: 10.1039/d1nr08252c.
  • Koo, K. M.; Dey, S.; Trau, M. A Sample-to-Targeted Gene Analysis Biochip for Nanofluidic Manipulation of Solid-Phase Circulating Tumor Nucleic Acid Amplification in Liquid Biopsies. ACS Sens. 2018, 3, 2597–2603. DOI: 10.1021/acssensors.8b01011.
  • Yazdi, M. K.; Ghazizadeh, E.; Noroozi, M.; Neshastehriz, A. Design of a DOPC-MoS2/AuNP Hybrid as an Organic Bed with Higher Amplification for miR Detection in Electrochemical Biosensors. Anal. Bioanal. Chem. 2020, 412, 3209–3219. DOI: 10.1007/s00216-020-02579-8.
  • Khaliliazar, S.; Ouyang, L.; Piper, A.; Chondrogiannis, G.; Hanze, M.; Herland, A.; Hamedi, M. M. Electrochemical Detection of Genomic DNA Utilizing Recombinase Polymerase Amplification and Stem-Loop Probe. ACS Omega. 2020, 5, 12103–12109. DOI: 10.1021/acsomega.0c00341.
  • Sheta, S. M.; El-Sheikh, S. M.; Osman, D. I.; Salem, A. M.; Ali, O. I.; Harraz, F. A.; Shousha, W. G.; Shoeib, M. A.; Shawky, S. M.; Dionysiou, D. D. A Novel HCV Electrochemical Biosensor Based on a Polyaniline@Ni-MOF Nanocomposite. Dalton Trans. 2020, 49, 8918–8926. DOI: 10.1039/d0dt01408g.
  • Wang, X.; Li, Y.; Zhao, M.; Wang, H.; Wan, Q.; Shi, C.; Ma, C. An Ultrafast Ratiometric Electrochemical Biosensor Based on Potential-Assisted Hybridization for Nucleic Acids Detection. Anal. Chim. Acta. 2022, 1211, 339915. DOI: 10.1016/j.aca.2022.339915.
  • Bu, S.; Liu, X.; Wang, Z.; Wei, H.; Yu, S.; Li, Z.; Hao, Z.; Liu, W.; Wan, J. Ultrasensitive Detection of Pathogenic Bacteria by CRISPR/Cas12a Coupling with a Primer Exchange Reaction. Sens. Actuators, B 2021, 347, 130630. DOI: 10.1016/j.snb.2021.130630.
  • Fang, B.; Jia, Z.; Liu, C.; Tu, K.; Zhang, M.; Zhang, L. A Versatile CRISPR Cas12a-Based Point-of-Care Biosensor Enabling Convenient Glucometer Readout for Ultrasensitive Detection of Pathogen Nucleic Acids. Talanta 2022, 249, 123657. DOI: 10.1016/j.talanta.2022.123657.
  • Shan, Y.; Zhang, Y.; Kang, W.; Wang, B.; Li, J.; Wu, X.; Wang, S.; Liu, F. Quantitative and Selective DNA Detection with Portable Personal Glucose Meter Using Loop-Based DNA Competitive Hybridization Strategy. Sens. Actuators, B 2019, 282, 197–203. DOI: 10.1016/j.snb.2018.11.062.
  • Papadakis, G.; Pantazis, A. K.; Ntogka, M.; Parasyris, K.; Theodosi, G.-I.; Kaprou, G.; Gizeli, E. 3D-Printed Point-of-Care Platform for Genetic Testing of Infectious Diseases Directly in Human Samples Using Acoustic Sensors and a Smartphone. ACS Sens. 2019, 4, 1329–1336. DOI: 10.1021/acssensors.9b00264.
  • Bai, H.; Wang, Y.; Li, X.; Guo, J. Electrochemical Nucleic Acid Sensors: Competent Pathways for Mobile Molecular Diagnostics. Biosens. Bioelectron. 2023, 237, 115407. DOI: 10.1016/j.bios.2023.115407.
  • Kampeera, J.; Pasakon, P.; Karuwan, C.; Arunrut, N.; Sappat, A.; Sirithammajak, S.; Dechokiattawan, N.; Sumranwanich, T.; Chaivisuthangkura, P.; Ounjai, P.; et al. Point-of-Care Rapid Detection of Vibrio parahaemolyticus in Seafood Using Loop-Mediated Isothermal Amplification and Graphene-Based Screen-Printed Electrochemical Sensor. Biosens. Bioelectron. 2019, 132, 271–278. DOI: 10.1016/j.bios.2019.02.060.
  • Velmanickam, L.; Jayasooriya, V.; Nawarathna, D. Integrated Dielectrophoretic and Impedimetric Biosensor Provides a Template for Universal Biomarker Sensing in Clinical Samples. Electrophoresis 2021, 42, 1060–1069. DOI: 10.1002/elps.202000347.
  • Ganbaatar, U.; Liu, C. NEXT CRISPR: An Enhanced CRISPR-Based Nucleic Acid Biosensing Platform Using Extended crRNA. Sens. Actuators, B 2022, 369, 132296. DOI: 10.1016/j.snb.2022.132296.
  • Qiao, J.; Lin, S.; Sun, W.; Ma, L.; Liu, Y. A Method for the Quantitative Detection of Cas12a Ribonucleoproteins. Chem. Commun. 2020, 56, 12616–12619. DOI: 10.1039/D0CC04019C.
  • Broughton, J. P.; Deng, X.; Yu, G.; Fasching, C. L.; Servellita, V.; Singh, J.; Miao, X.; Streithorst, J. A.; Granados, A.; Sotomayor-Gonzalez, A.; et al. CRISPR–Cas12-Based Detection of SARS-CoV-2. Nat. Biotechnol. 2020, 38, 870–874. DOI: 10.1038/s41587-020-0513-4.
  • Ding, X.; Bin, P.; Wu, W.; Chang, Y.; Zhu, G. Tryptophan Metabolism, Regulatory T Cells, and Inflammatory Bowel Disease: A Mini Review. Mediators Inflamm. 2020, 2020, 9706140. DOI: 10.1155/2020/9706140.
  • Gootenberg, J. S.; Abudayyeh, O. O.; Lee, J. W.; Essletzbichler, P.; Dy, A. J.; Joung, J.; Verdine, V.; Donghia, N.; Daringer, N. M.; Freije, C. A.; et al. Nucleic Acid Detection with CRISPR-Cas13a/C2c2. Science 2017, 356, 438–442. DOI: 10.1126/science.aam9321.
  • Wu, C.; Chen, Z.; Li, C.; Hao, Y.; Tang, Y.; Yuan, Y.; Chai, L.; Fan, T.; Yu, J.; Ma, X.; et al. CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant. Nanomicro. Lett. 2022, 14, 159. DOI: 10.1007/s40820-022-00888-4.

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