The Role of Factors that Regulate the Synthesis and Secretion of Very-Low-Density Lipoprotein by Hepatocytes

References

• Swift LL. Assembly of very low density lipoproteins in rat liver: a study of nascent particles recovered from the rough endoplasmic reticulum. J Lipid Res 1995; 36: 395–406.
   Google Scholar
• Gruffat D, Durand D, Graulet B, et al. Regulation of VLDL synthesis and secretion in the liver. Reprod Nutr Dev 1996; 36: 375–89.
   Google Scholar
• Dixon JL, Ginsberg HN. Regulation of hepatic secretion of apolipoprotein B-containing lipoprotein: information obtained from cultured liver cells. J Lipid Res 1993; 34: 167–79.
   PubMed Web of Science ®Google Scholar
• Krishnaiah KV, Walker LF, Borensztajn J, et al. Apolipoprotein B variant derived from rat intestine. Proc Natl Acad Sci USA 1980; 77: 3806–10.
   Google Scholar
• Chen SH, Habib G, Yang CY, et al. Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon. Science 1987; 238: 263–6.
   Google Scholar
• Yao Z, McLeod RS. Synthesis and secretion of hepatic apolipoprotein B-containing lipoproteins. Biochim Biophys Acta 1994; 1212: 152–66.
   PubMedGoogle Scholar
• Cartwright J, Higgins J. Intracellular degradation in the regulation of secretion of apolipoprotein B-100 by rabbit hepatocytes. Biochem J 1996; 314: 977–84.
   Google Scholar
• Benoist F, Grand-Perret T. Apo B-100 secretion by HepG2 cells is regulated by the rate of triglyceride biosynthesis but not by intracellular lipid pools. Arterioscler Thromb Vasc Biol 1996; 16: 1229–35.
   Google Scholar
• Gibbons GF, Wiggins D. Intracellular triacylglycerol lipase: its role in the assembly of hepatic very-low-density lipoprotein (VLDL). Adv Enzyme Regul 1995; 35: 179–98.
   PubMedGoogle Scholar
• Elovson J, Chatterton JE, Bell GT, et al. Plasma very low density lipoproteins contain a single molecule of apolipoprotein B. J Lipid Res 1988; 29: 1461–73.
   PubMed Web of Science ®Google Scholar
• Rusinol A, Verkade H Vance JE. Assembly of rat hepatic very-low-density lipoprotein in the endoplasmic reticulum. J Biol Chem 1993; 268: 3555–62.
   Google Scholar
• Sparks JD, Sparks CE. Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion. Biochim Biophys Acta 1994; 1215: 9–32.
   PubMedGoogle Scholar
• Hamilton RL, Havel RJ. Is microsomal triglyceride transfer protein the missing link in abetalipoproteinemia? Hepatology 1993; 18: 460–3.
   Google Scholar
• Kardassis D, Zannis VI Cladaras C. Organization of the regulatory elements and nuclear activities participating in the transcription of the human apolipoprotein B gene. J Biol Chem 1992; 267: 2622–32.
   PubMed Web of Science ®Google Scholar
• Dashti N, Williams DL Alaupovic P. Effects of oleate and insulin on the production rates and cellular mRNA concentrations of apolipoproteins in HepG2 cells. J Lipid Res 1989; 30: 1365–73.
   PubMed Web of Science ®Google Scholar
• Pullinger CR, North JD, Teng BB, et al. The apolipoprotein B gene is constitu-tively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life. J Lipid Res 1989; 30: 1065–77.
   PubMed Web of Science ®Google Scholar
• Dixon JL, Furukawa S Ginsberg HN. Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B. J Biol Chem 1991; 266: 5080–6.
   PubMedGoogle Scholar
• Wang C, McLeod RS, Yao Z, et al. Effects of dexamethasone on the synthesis, degradation, and secretion of apolipoprotein B in cultured rat hepatocytes. Arterioscler Thromb Vasc Biol 1995; 15: 1481–91.
   Google Scholar
• Chuck SL, Lingappa VR. Analysis of a pause transfer sequence from apolipoprotein B. J Biol Chem 1993; 268: 22794–801.
   Google Scholar
• Davis RA, Prewett AB, Chan DCF, et al. Intrahepatic assembly of very low density lipoproteins: immunologic characterization of apolipoprotein B in lipo-proteins and hepatic membrane fractions and its intracellular distribution. J Lipid Res 1989; 30: 1985–96.
   Google Scholar
• Davis RA, Thrift RN, Wu CC, et al. Apolipoprotein B is both integrated into and translocated across the endoplasmic reticulum membrane. J Biol Chem 1990; 265: 1005–11.
   Google Scholar
• Bonnardel JA, Davis RA. In Hep G2 cells, translocation, not degradation, determines the fate of the de novo synthesized apolipoprotein B. J Biol Chem 1995; 270: 28892–6.
   Google Scholar
• Rusinol AE, Chan EYW Vance JE. Movement of apolipoprotein B into the lumen of microsomes from hepatocytes is disrupted in membranes enriched in phosphatidylmonomethylethanolamine. J Biol Chem 1993; 268: 25168–75.
   Google Scholar
• Macri J, Adeli K. Studies on intracellular translocation of apolipoprotein B in a permeabilized Hep G2 system. J Biol Chem 1997; 272: 7328–37.
   Google Scholar
• MacLeod RS, Wang Y, Wang S, et al. Apolipoprotein B sequence requirements of hepatic very low density lipoprotein assembly. J Biol Chem 1996; 271: 18445–55.
   Google Scholar
• Gordon DA, Jamil H Sharp D. Secretion of apolipoprotein B-containing lipopro-teins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability. Proc Natl Acad Sci USA 1994; 91: 7628–32.
   Google Scholar
• Benoist F, Nicodeme E Grand-Perret T. Microsomal triacylglycerol transfer protein prevents presecretory degradation of apolipoprotein B-100. Eur J Biochem 1996; 240: 713–20.
   Google Scholar
• Borchardt RA, Davis RA. Intrahepatic assembly of very low density lipopro-teins. J Biol Chem 1987; 262: 16394–402.
   PubMed Web of Science ®Google Scholar
• Adeli K. Regulated intracellular degradation of apolipoprotein B in semiperme-able Hep G2 cells. J Biol Chem 1994; 269: 9166–75.
   PubMed Web of Science ®Google Scholar
• Furukawa S, Sakata N, Ginsberg HN, et al. Studies of the sites of intracellular degradation of apolipoprotein B in Hep G2 cells. J Biol Chem 1992; 267: 22630–22638.
   PubMed Web of Science ®Google Scholar
• Wang C, Hobman TC Brindley DN. Degradation of apolipoprotein B in cultured rat hepatocytes occurs in a post-endoplasmic reticulum compartment. J Biol Chem 1995; 270: 24924–31.
   Google Scholar
• Dixon JL, Chattapadhyay R Huima T. Biosynthesis of lipoprotein: location of nascent apo AI and apo B in the rough endoplasmic reticulum of chicken hepatocytes. J Cell Biol 1992; 117: 1161–9.
   PubMed Web of Science ®Google Scholar
• Fisher EA, Zhou M, Mitchell DM, et al. The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J Biol Chem 1997; 272: 20427–34.
   PubMed Web of Science ®Google Scholar
• Adeli K, Macri J, Mohammadi A, et al. Apolipoprotein B is intracellularly associated with an ER-60 protease homologue in HepG2 cells. J Biol Chem 1997; 272: 22489–94.
   PubMed Web of Science ®Google Scholar
• Yao Z, Vance DE. The active synthesis of phosphatidylcholine is required for very-low-density lipoprotien secretion from rat hepatocytes. J Biol Chem 1988; 263: 2998–3004.
   PubMed Web of Science ®Google Scholar
• Thompson GR, Naoumova RP Watts GF. Role of cholesterol in regulating apolipoprotein B secretion by the liver. J Lipid Res 1996; 37: 439–47.
   PubMed Web of Science ®Google Scholar
• Butterwith SC, Martin A Brindley DN. Can phosphorylation of phosphatidate phosphorylase by a cyclic AMP-dependent mechanism regulate its activity and subcellular distribution and control hepatic glycerolipid synthesis? Biochem J 1984; 222: 487–93.
   Google Scholar
• Brindley DN, McCann BS, Niaura R, et al. Stress and lipoprotein metabolism: modulators and mechanisms. Metabolism1993; 42: 3–15.
   Google Scholar
• George TP, Morash SC, Cook HW, et al. Phosphatidylcholine biosynthesis in cultured glioma cells: evidence for channeling of intermediates. Biochim Biophys Acta 1989; 1004: 283–91.
   PubMedGoogle Scholar
• Pelech SL, Pritchard PH, Brindley DN, et al. Fatty acids reverse the cyclic AMP inhibition of triacylglycerol and phosphatidylcholine synthesis in rat hepato-cytes Biochem J 1983; 216: 129–36.
   Google Scholar
• Hatch GM, Jamil H, Utal AK, et al. On the mechanism of the okadaic acid-induced inhibition of phosphatidylcholine biosynthesis in isolated rat hepato-cytes. J Biol Chem 1992. 267: 15751–58.
   Google Scholar
• Yao Z, Vance DE. Head group specificity in the requirement of phosphatidyl-choline biosynthesis for very-low-density lipoprotein secretion from cultured hepatocytes. J Biol Chem 1989; 264: 11373–80.
   PubMed Web of Science ®Google Scholar
• Rusinol AE, Vance JE. Inhibition of secretion of truncated apolipoproteins B by monomethylethanolamine is independent of the length of the apolipoprotein. J Biol Chem 1995; 270: 13318–28.
   Google Scholar
• Verkade HJ, Fast DG, Rusinol AE, et al. Impaired synthesis of phosphatidylcho-line causes a decrease in the number of very-low-density lipoprotein particles in the Golgi but not in the endoplasmic reticulum of rat liver. J Biol Chem 1993; 268: 24990–6.
   Google Scholar
• Tarugi P, Nicolini S, Ballarini G, et al. Synthesis and secretion of B-100 and A-I apolipoproteins in response to the changes of intracellular cholesteryl ester content in chick liver. J Lipid Res 1996; 37: 493–507.
   Google Scholar
• Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeo-stasis. Science 1986; 232: 34–47.
   PubMed Web of Science ®Google Scholar
• Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990; 343: 425–30.
   PubMed Web of Science ®Google Scholar
• Goldstein JL, Hobbs HH Brown MS. Familial hypercholesterolemia. In: Scriver CR, Beaudet AL, Sly WS Valle D, eds. The metabolic and molecular bases of inherited disease, Vol. 2, 7th ed., Pp. 1981-2030. New York: McGraw-Hill, 1995.
   Google Scholar
• Graham A, Wood JL, Russel LJ. Cholesterol esterification is not essential for secretion of lipoprotein components by HepG2 cells. Biochim Biophys Acta 1996; 1302: 46–54.
   Google Scholar
• Carr TP, Hamilton RL Rudel LL. ACAT inhibitors decrease secretion of cholesteryl esters and apolipoprotein B by perfused livers of African green monkeys. J Lipid Res 1995; 36: 25–36.
   Google Scholar
• Tanaka MH, Jingami H, Otani H, et al. Regulation of apolipoprotein B production and secretion in response to the change of intracellular cholesteryl ester contents in rabbit hepatocytes. J Biol Chem 1993; 268: 12713–8.
   Google Scholar
• Gibbons GF, Bartlett SM, Sparks CE, et al. Extracellular fatty acids are not utilized directly for the synthesis of very-low-density lipoprotein in primary cultures of rat hepatocytes. Biochem J 1992; 287: 749–53.
   Google Scholar
• Yang L, Kuksis A Myher JJ. Contribution of de novo fatty acid synthesis to very low density lipoprotein triacylglycerols: evidence from mass isotopomer distribution analysis of fatty acids synthesized from [2H6]ethanol. J Lipid Res 1996; 37: 262–74.
   Google Scholar
• Wu X, Shang A, Jiang H, et al. Low rates of apoB secretion from Hep G2 cells result from reduced delivery of newly synthesized triglyceride to a “secretion-coupled” pool. J Lipid Res 1996; 37: 1198–206.
   PubMed Web of Science ®Google Scholar
• Jamil H, Dickson JK, Chu CH, et al. Microsomal triglyceride transfer protein. J Biol Chem 1995; 270: 6549–54.
   PubMed Web of Science ®Google Scholar
• Wiggins D, Gibbons GF; The lipolysis/esterification cycle of hepatic triacyglycerol. Biochem J 1992; 284: 457–462.
   Google Scholar
• Stacpoole PW, Harwood HJ Jr Varnado CE. Dietary carbohydrate decreases 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and cholesterol synthesis in rat liver. Biochem Biophys Res Commun 1983; 113: 888–94.
   Google Scholar
• Sniderman AD, Cianflone K. Substrate delivery as a determinant of hepatic apo B secretion. Arterioscler Thromb 1993; 13: 629–36.
   PubMedGoogle Scholar
• Gibbons GF. Assembly and secretion of hepatic very-low-density lipoprotein. Biochem J 1990; 268: 1–13.
   PubMed Web of Science ®Google Scholar
• Van Greevenbroek MMJ, Van Meer G, Erkelens DW, et al. Effects of saturated, mono, and polyunsaturated fatty acids on the secretion of apoB containing lipoproteins by Caco-2 cells. Atherosclerosis 1996; 121: 139–150.
   Google Scholar
• Abdel-Fattah G, Fernandez ML McNamara DJ. Regulation of guinea pig very low density secretion rates by dietary fat saturation. J Lipid Res 1995; 36: 1188–98.
   Google Scholar
• Kalogeris TJ, Story JA. Lymph chylomicron size is modified by fat saturation in rats. J Nutr 1992; 122: 1634–42.
   Google Scholar
• Sharp D, Blinderman L, Combs KA, et al. Cloning and gene defects in microso-mal triglyceride transfer protein associated with abetalipoproteinaemia. Nature 1993; 365: 65–9.
   PubMed Web of Science ®Google Scholar
• Gordon DA, Jamil H, Gregg RE, et al. Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step. J Biol Chem 1996; 271: 33047–53.
   PubMed Web of Science ®Google Scholar
• Wang Y, McLeod RS Yao Z. Normal activity of microsomal triglyceride transfer protein is required for the oleate-induced secretion of very low density lipoproteins containing apolipoprotein B from McA-RH7777 cells. J Biol Chem 1997; 272: 12272–8.
   Google Scholar
• Innerarity TL, Boren J, Yamanaka S, et al. Biosynthesis of apolipoprotein B48-containing lipoproteins. J Biol Chem 1996; 271: 2353–6.
   PubMed Web of Science ®Google Scholar
• Sparks JD, Phung TL, Bolognino M, et al. Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and phosphatidylinositol 3-kinase activation: studies with brefeldin A and wortmannin in primary cultures of rat hepatocytes. Biochem J 1996; 313: 567–574.
   Google Scholar
• Wetterau JR, Lin MCM, Jamil H. Microsomal triglyceride transfer protein. Biochim Biophys Acta 1997; 1345: 136–50.
   PubMed Web of Science ®Google Scholar
• Lewis GF, Uffelman KD, Szeto LW, et al. Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J Clin Invest 1995; 95: 158–66.
   PubMed Web of Science ®Google Scholar
• Duerden JM, Gibbons GF. Storage, mobilization and secretion of cytosolic triacylglycerol in hepatocyte cultures. The role of insulin. Biochem J 1990; 272: 583–7.
   Google Scholar
• Backer JM, Schroeder GG, Kahn CR, et al. Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substitute phosphorylation. J Biol Chem 1992; 267: 1367–74.
   PubMed Web of Science ®Google Scholar
• Lin Y, Havinga R, Schippers IJ, et al. Characterization of the inhibitory effects of bile acids on very-low-density lipoprotein secretion by rat hepatocytes in primary culture. Biochem J 1996; 316: 531–38.
   Google Scholar
• Lin Y, Havinga R, Verkade HJ, et al. Bile acids suppress the secretion of very-low-density lipoprotein by human hepatocytes in primary culture. Hepatology 1996; 23: 218–28.
   Google Scholar
• Duane WC. Abnormal bile acid absorption in familial hypertriglyceridemia. J Lipid Res 1995; 36: 96–107.
   Google Scholar