Nutraceutical Applications of Garlic and the Intervention of Biotechnology

REFERENCES

• Abo El-Nil , N. 1977 . Organogenesis and embryogenesis in callus cultures of garlic (Allium sativum L.) . Plant Sci. Lett. , 9 : 259 – 264 . [CSA]
   Google Scholar
• Adetumbi , M. and Lau , B. H.S. 1983 . Allium sativum (garlic)—a natural antibiotic . Medical Hypotheses , 12 : 227 – 237 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Adler , A. J. and Holub , B. J. 1997 . Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men . Am. J. Clin. Nutr. , 65 : 445 – 450 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Agarwal , K. C. 1996 . Therapeutic actions of garlic constituents . Med. Res. Rev. , 16 : 111 – 124 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Al-Zahim , M. A. , Ford-Lioyd , B. V. and Newbury , H. J. 1999 . Detection of somaclonal variation in garlic (Allium sativum L.) using RAPD and cytological analysis . Plant Cell Rep. , 18 : 473 – 477 . [CSA] [CROSSREF]
   Web of Science ®Google Scholar
• Amagase , H. and Milner , J. A. 1993 . Impact of various sources of garlic and their constituents on 7, 12-dimethylbenz-[a]-anthracene binding to mammary cell DNA . Carcinogenesis , 14 : 1627 – 1631 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Amagase , H. , Schaffer , E. M. and Milner , J. A. 1996 . Dietary components modify the ability of garlic to suppress 7,12-methylbenz(a)anthracene-induced mammary DNA adducts . J. Nutr. , 126 : 817 – 824 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Amagase , H. , Petesch , B. L. and Matsuura , H. 2001 . Intake of garlic and its bioactive components . J. Nutr. , 131 : 955S – 926S . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Anesini , C. and Perez , C. 1993 . Screening of Plants used in Argentine Folk Medicine for Antimicrobial Activity . J. Ethnopharm , 39 : 119 – 128 . [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Anim-Nyame , N. , Sooranna , S. R. , Johnson , M. R. , Gamble , J. and Steer , P. J. 2004 . Garlic supplementation increases peripheral blood flow; a role for interleukin-6? . J. Nutr. Biochem. , 15 : 30 – 36 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Arora , R. C. and Arora , S. 1981 . Comparative effect of clofibrate, garlic and onion on alimentary hyperlipemia . Atherosclerosis , 39 : 447 – 452 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Arora , R. C. , Arora , S. and Gupta , R. K. 1981 . The long-term use of garlic in ischaemic heart disease-an appraisal . Atherosclerosis , 40 : 175 – 179 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Augusti , K. T. and Sheela , C. G. 1996 . Antiperoxide effect of S-allyl cysteine sulfoxide, a insulin secretagogue, in diabetic rats . Experientia , 52 : 115 – 120 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Aukris , S. 1999 . Antimicrobial properties of Allicin from garlic (Review) . Microbes infect. , 11 : 125 – 129 . [CSA]
   Google Scholar
• Ayabe , M. and Sumi , S. 1998 . Establishment of a novel tissue culture method, stem-disc culture, and its practical application to micropropagation of garlic (Allium sativum L.) . Plant Cell Rep , 17 : 773 – 779 . [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Baluchnejadmojarad , T. , Roghani , M. , Homayounfar , H. and Hosseini , M. 2003a . Beneficial effect of aqueous garlic extract on the vascular ractivity of streptozotocin-diabetic rats . J. Ethnoparm. , 85 : 139 – 144 . [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Baluchnejadmojarad , T. and Roghani , M. 2003b . Endothelium-dependent and – independent effect of aqueous extract of garlic on vascular reactivity on diabetic rats . Fitoterapia , 74 : 630 – 637 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Banerjee , S. K. and Maulik , S. K. 2002 . Effect of garlic on cardiovascular disorders: A review . Nutritional Jour. , 1 ( 4 ) : 1 – 14 . [CSA]
   Google Scholar
• Banerjee , S. K. , Maulik , M. , Mancahanda , S. C. , Dinda , A. K. , Gupta , S. K. and Maulik , S. K. 2002 . Dose dependent induction of endogenous anti oxidants in rat heart by chronic administration of garlic . Life Scie. , 70 : 1509 – 1518 . [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Barandiaran , X. , Di Pietro , A. and Martin , J. 1998 . Biolistic transfer and expression of a uid–A reporter gene in different tissues of Allium sativum L . Plant Cell Rep. , 17 : 737 – 741 . [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Barandiaran , X. , Martin , N. , Rodriguez-Conde , M. F. and Di Pietro , A. 1999a . An efficient method for callus culture and shoot regeneration of garlic (Allium sativum L.) . Hortic. Sci , 34 : 348 – 349 . [CSA]
   Google Scholar
• Barandiaran , X. , Martin , N. and Rodriguez-Conde , M. F. 1999b . Genetic variability in callus formation and regeneration of garlic (Allium sativum L.) . Plant Cell Rep. , 18 : 434 – 437 . [CSA] [CROSSREF]
   Google Scholar
• Berthold , H. K. , Sudhop , T. and Von Bergmann , K. 1998 . Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism: A randomized controlled trail . J. Am. Med. Assoc. , 279 : 1900 – 1902 . [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bhagyalakshmi , N. 1999 . “ Flavour formation in cultured plant cells and tissues - I. The prior art ” . In Biotechnology of Medicinal and Aromatic Plants , Edited by: Khan , Irfan and Khanum , Athia . Vol. II , 309 – 345 . Hyderabad : Ukaaz Publication .
   Google Scholar
• Bhagyalakshmi , N. , Suvarnalatha , G. and Venkataraman , L. V. 2000 . “ Production and processing of flavour compounds from cultured cells and tissues ” . In Tissue Culture and Biotechnology of Horticultural Crops , Edited by: Chadha , K. L. 528 – 547 . New Delhi : Malhotra Publishing House .
   Google Scholar
• Bhojwani , S. S. 1980 . In vitro propagation of garlic by shoot proliferation . Sci. Hortic., , 13 : 47 – 52 . [CSA] [CROSSREF]
   Google Scholar
• Block , E. 1985 . The chemistry of garlic and onions . Sci. Am , 252 : 114 – 119 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Block , E. 1992 . The organosulfur chemistry of the genus Allium—Implicatons for the organic chemistry of sulfur . Angew Chem. Int. Edn. Engl. , 31 : 1135 – 1178 . [CSA] [CROSSREF]
   Web of Science ®Google Scholar
• Bordia , A. 1981 . Effect of garlic on blood lipids in patients with coronary heart disease . Am. J. Clin. Nutr. , 34 : 2100 – 2103 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Broglia , M. and Corona , C. 1995 . Treatment of maize pollen to reduce nuclease activity . Sex Plant Reprod. , 8 : 187 – 188 . [CSA] [CROSSREF]
   Google Scholar
• Cannizares , P. , Gracia , I. , Gomez , L. A. , de Argila , C. M. , de Rafael , L. and Gracia , A. 2002 . Optimization of Allium sativum solvent extraction for the inhibition of in vitro growth of Helicobacter pylori. . Biotech. Prog. , 18 : 1227 – 1232 . [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Caporaso , N. , Smith , S. M. and Eng , R. H. 1983 . Antifungal activity in human urine and serum after ingestion of garlic (Allium sativum) . Antimicrob. Agents Chemother. , 23 : 700 – 702 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Cellini , L. , Di Campli , E. , Masulli , M. , De Bartolomeo , S. and Allocati , N. 1996 . Inhibition of Helicobacter pylori by Garlic Extract (Allium sativum) . FEMS Immunology and Medical Microbiology , 13 : 273 – 277 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Challier , B. , Perarnau , J. M. and Viel , J. F. 1998 . Garlic, onion and cereal fibre as protective factors for breast cancer: A French case–control study . Eur. J. Epidemiol. , 14 : 737 – 747 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chovelon , V. , Leroux , J. P. and Dore , C. 1990 . “ Selection sanitaire de lail et de lechalote: Culture de meristemes et regeneration de varieties ” . In Clinquantenaire de la culture in vitro. colloques de l INRA , Edited by: Dore , C. Vol. 51 , 142 – 150 . Paris : INRA .
   Google Scholar
• Chovelon , V. , Leroux , J. P. , Delecolle , B. , Foret , L. , Messiaen , C. M. and Lot , H. Production and breeding of virus-free garlic clones in France (abstract) . Ist International Symposium on Edible Alliaceae . March 14 1994 , Mendoza, Argentina.
   Google Scholar
• Chowdhury , A. K.Z. , Ahsan , M. , Islam , S. N. and Ahmed , Z. U. 1991 . Efficacy of aqueous extract of garlic and allicin in experimental shigellosis in rabbits . Indian J. Medic. Res. , 93 : 33 – 36 . [CSA]
   PubMedGoogle Scholar
• Dausch , J. G. and Nixon , D. W. 1990 . Garlic: A review of its relationship to malignant disease . Prev. Med. , 19 : 346 – 361 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Davis , L. E. , Shen , J. K. and Cai , Y. 1990 . Antifungal activity in human cerebrospinal fluid and plasma after intravenous administration of Allium sativum . Antimicrobial Agents and Chemotherapy , 30 : 651 – 653 . [CSA]
   Google Scholar
• Davis , L. E. , Shen , J. and Royer , R. E. 1994 . In vitro synergism of concentrated Allium sativum extract and amphotericin B against Cryptococcus neoformans . Planta Medica , 60 : 546 – 549 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Dewick , P. M. 2002 . “ Peptides, proteins and other amino acid derivatives ” . In Medicinal Natural Products—A Biosynthetic Approach. , Edited by: Dewick , P. M. 405 – 461 . New York, , USA : John Wiley & Sons .
   Google Scholar
• Dolezel , J. and Novak , F. J. 1985 . Caryological and cytophotometric study of callus induction in Allium sativum L . Plant Physiol. , 118 : 421 – 429 . [CSA]
   Google Scholar
• Dong , N. , Hubstenberger , J. and Phillips , G. 1997 . Apparent transformation of Allium fistulosum suspension cultures by A grobacterium tumefaciens . Allium Improvement Newsletter , 7 : 12 – 14 . [CSA]
   Google Scholar
• Dorant , E. , van den Brandt , P. A. , Goldbohm , R. A. , Hermus , R. J.J. and Sturmans , F. 1993 . Garlic and its significance for the prevention of cancer in humans: A critical view . Br. J. Cancer , 67 : 424 – 429 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Dunstan , D. I. and Short , K. C. 1978 . Shoot production from onion callus tissue culture . Sci Hortic. , 9 : 99 – 110 . [CSA] [CROSSREF]
   Web of Science ®Google Scholar
• Eady , C. 1995 . Towards the transformation of onion (Allium cepa) . NZ J. Crop Hort. Sci. , 23 : 239 – 250 . [CSA]
   Web of Science ®Google Scholar
• Ernst , E. 1987 . Cardiovascular effects of garlic (Allium sativum): A review . Pharmatherapeutica , 5 : 83 – 89 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Farva , D. , Goji , L. A. , Joseph , P. K. and Augusti , K. T. 1986 . Effects of garlic oil on streptozotocin-diabetic rats maintained on normal and high fat diets . Indian J. Biochem. Biophys. , 23 : 24 – 27 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Feldberg , R. S. , Chang , S. C. , Kotik , A. N. , Nadler , M. , Neuwirth , Z. , Sundstrom , D. C. and Thompson , N. H. 1988 . In vitro mechanism of inhibition of bacterial cell growth by Allicin . Antimicrobial Agents and Chemotherapy , 32 : 1763 – 1768 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Fereol , L. , Chovelon , V. , Causse , S. , Michaux-Ferere , N. and Khane , R. 2002 . Evidence of somatic embryogenesis process for plant regeneration in garlic . Plant Cell Rep. , 21 : 197 – 203 . [CSA] [CROSSREF]
   Web of Science ®Google Scholar
• Fleischauer , A. T. and Arab , L. 2001 . Garlic and cancer: A critical review of the epidemiologic literature . J. Nutrition , 131 : 1032S – 1040S . [CSA]
   PubMed Web of Science ®Google Scholar
• Fukushima , S. , Takada , N. , Hori , T. and Wanibuchi , H. 1997 . Cancer prevention by organosulfur compounds from garlic and onion . J. Cell Biochem. , 27 ( suppl. ) : 100 – 105 . [CSA] [CROSSREF]
   Google Scholar
• Gamborg , O. , Miller , R. and Ojima , K. 1968 . Nutrient requirements of suspension cultures of soybean root cells . Exp. Cell Res. , 50 : 151 – 158 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Gebhardt , R. 1993 . Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes . Lipids , 28 : 613 – 619 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Gebhardt , R. and Beck , H. 1996 . Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures . Lipids , 31 : 1269 – 1276 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Ghazanfari , T. , Hassan , Z. M. , Ebtekar , M. , Ahmadiani , A. , Naderi , G. and Azar , A. 2000 . Garlic induces a shift in cytokine pattern in Leishmania major infected BALB/c mice . Scand. J. Immunol , 52 : 491 – 495 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Hans-Peter , K. , Verena , M. D. , Thomas , H. , Thomas , H. , Laurnce , T. , Jaques , A. , Remi , K. and Angelika , M. V. 2003 . Garlic (Allium ativum L.) Modulates Cytokine expression in lipopolysaccharide activated human blood thereby inhibiting NF-k B activity . The J. Nutr. , 133 : 2171 – 2175 . [CSA]
   PubMedGoogle Scholar
• Haque , M. S. , Wada , T. and Hattori , K. 1997 . High frequency shoot regeneration and plantlet formation from root tip of female garlic . Plant Cell, Tiss. and Org. Cult. , 50 : 83 – 89 . [CSA] [CROSSREF]
   Google Scholar
• Haque , M. S. , Wada , T. and Hattori , K. 1998 . Efficient plant regeneration in garlic through somatic embryogenesis from root tip explants . Plant Prod. Sci. , 1 : 216 – 222 . [CSA]
   Google Scholar
• Havranek , P. and Novak , E. 1973 . The bud formation in the callus cultures of Allium sativum L . Z. Pflanzenphysiol , 68 : 308 – 318 . [CSA]
   Google Scholar
• Hirsch , K. , Danilenko , M. , Giat , J. , Miron , T. , Rabinkov , A. , Wilchek , M. , Mirelman , D. , Levy , J. and Sharoni , Y. 2000 . Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation . Nutr Cancer , 38 : 245 – 254 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ho , S. E. , Ide , N. and Lau , B. H. 2001 . S-allyl cysteine reduces oxidant load in cells involved in the atherogenic process . Phytomedicine , 8 : 39 – 46 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hodge , G. , Hodge , S. and Han , P. 2002 . Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: Potential therapeutic use in the treatment of inflammatory bowel disease . Cytometry , 48 : 209 – 215 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Ide , N. and Lau , B. H. 2001 . Garlic compounds minimise intracellular oxidative stress and inhibit nuclear factor-kB activation . J. Nutr. , 131 : 1020S – 1026S . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Ikeda , H. , Iizuka , M. , Hayashi , K. and Kurihara , N. 1997 . Agrobacterium tumefaciens-mediated transformation of Allium fistulosum L . Breed Sci. , 47 : 171 [CSA]
   Google Scholar
• Ip , C. , Lisk , D. J. and Stoewsand , G. S. 1992 . Mammary cancer prevention by regular garlic and selenium-enriched garlic . Nutr. Cancer , 17 : 279 – 286 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Isaacsohn , J. L. , Moser , M. , Stein , E. A. , Dudley , K. , Davey , J. A. , Liskov , E. and Black , H. R. 1998 . Garlic powder and plasma lipids and lipoproteins . Arch. Intern. Med. , 158 : 1189 – 1194 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jain , A. K. , Vargas , R. , Gotzkowsky , S. and McMahon , F. G. 1993 . Can garlic reduce levels of serum lipids? A controlled clinical study . Am. J. Med. , 94 : 632 – 635 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Jain , R. C. and Vyas , C. R. 1975 . Garlic in alloxan—induced diabetic rabbits . Am. J. Clin. Nutr. , 28 : 684 – 685 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Jardinaud , M. , Souvre , A. and Alibert , G. 1993 . Transient GUS gene expression in Brassica napus electroporated microspores . Plant Sci. , 93 : 177 – 184 . [CSA] [CROSSREF]
   Google Scholar
• Kahane , R. , Rancillac , M. and Schweisguth , B. 1992 . Bulbing in vitro in Allium species . Allium Improve. Newsl. , 2 : 18 – 20 . [CSA]
   Google Scholar
• Kasuga , S. , Ushijima , M. , Morihara , N. , Itakura , Y. and Nakata , Y. 1999 . Effect of aged garlic extract (AGE) on hyper glycemia induced immobilization stress in mice . Nippon yakurigaku Zassh , 114 : 192 – 197 . [CSA]
   Google Scholar
• Kehr , A. and Schaeffer , G. 1976 . Tissue culture and differentiation of garlic . Hortic. Sci. , 11 : 422 – 423 . [CSA]
   Google Scholar
• Kiesewetter , H. , Jung , F. , Jung , E. M. , Mroweitz , C. , Koscielny , J. and Wenzel , E. 1993 . Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack . Eur. J. Clin. Pharm. , 45 : 333 – 336 . [CSA]
   PubMedGoogle Scholar
• Keiss , H. P. , Dirsch , V. M. , Hartung , T. , Haffner , T. , Trueman , L. , Auger , J. , Kahane , R. and Vollmar , A. M. 2003 . Garlic (Allium sativum L.) modulates cytokine expression in lipopolysaccharide-activated human blood thereby inhibiting NF-kappaB activity . J. Nutr. , 133 : 2171 – 2175 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Koch , H. P. and Lawson , L. D. 1996 . Garlic—The Science and Therapeutic Application of Allium sativum L. and Related species , Maryland, , USA : Williams and Wilkins .
   Google Scholar
• Koch , M. , Tanami , Z. and Salomon , R. 1995 . Improved regeneration of shoots from garlic callus . Hort. Scie. , 30 : 378 [CSA]
   Google Scholar
• Kondo , T. , Hasegawa , H. and Suzuki , M. 2000 . Transformation and regeneration of garlic (Allium sativum L.) by Agrobacterium-mediated gene transfer . Plant Cell Rep. , 19 : 989 – 993 . [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Koul , S. , Sambyal , M. and Grewal , S. 1994 . Embryogenesis and plant formation in garlic Allium sativum L . J. Spices Aromatic Crops , 3 : 43 – 47 . [CSA]
   Google Scholar
• Kroemer , G. 1997 . The proto-oncogene Bcl-2 and its role in regulating apoptosis . Nature Med. , 3 : 614 – 620 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Kumar , G. R. and Reddy , K. B. 1999 . Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum L.) treatment . Indian J. Exp. Biol. , 37 : 662 – 666 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Kyo , E. , Uda , N. , Kasuba , S. and Itakura , Y. 2001 . Immunomodulatory effects of aged garlic extract . J. Nutr. , 135 : 1075S – 1079S . [CSA]
   Google Scholar
• Lancaster , J. E. , Dommisse , E. M. and Shaw , M. L. 1988 . Production of flavour precursors (S-alkenyl-L cysteine sulphoxides) in photomicrotropic callus of garlic . Phytochemistry , 27 : 2123 – 2124 . [CSA] [CROSSREF]
   Web of Science ®Google Scholar
• Larkin , P. J. and Scowcroft , W. R. 1981 . Somaclonal variation: A novel source of variability from cell cultures for plant improvement . Theor. Appl. Genet. , 60 : 197 – 214 . [CSA]
   PubMed Web of Science ®Google Scholar
• Lawson , L. D. , Wang , Z. J. and Hughes , B. G. 1991 . Identification and HPLC quantitation of the sulfides and dialk(en)yl thiosulfinates in commercial garlic products . Planta Med. , 57 : 363 – 326 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Lea , M. A. and Ayyala , U. S. 1997 . Differentiating and growth inhibitory effects of diallyl disulfide on cancer cells . Int. J. Oncol. , 11 : 181 – 185 . [CSA]
   PubMedGoogle Scholar
• Li , Q. and Verma , I. M. 2002 . NF-kB regulation in the immune system . Nat. Rev. Immunol. , 2 : 725 – 734 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Liu , L. and Yeh , Y. Y. 2000 . Inhibition of cholesterol biosynthesis by organosulfur compounds derived from garlic . Lipids , 35 : 197 – 203 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Lun , Z. R. , Burri , C. , Menzinger , M. and Kaminsky , R. 1994 . Antiparasitic Activity of Diallyl Trisulfide (Dasuansu) on Human and Animal Pathogenic Protozoa (Trypanosoma sp. Entamoeba histolytica and Giardia lamblia) in vitro . Ann. Soc. belge Méd. trop. , 74 : 51 – 59 . [CSA]
   PubMedGoogle Scholar
• Madhavi , D. L. , Prabha , T. N. , Singh , N. S. and Patwardhan , M. V. 1991 . Biochemical studies with Garlic (Allium sativum) cell cultures showing different flavour levels . J. Sci. Food Agric. , 56 : 15 – 24 . [CSA]
   Web of Science ®Google Scholar
• Malpathak , N. P. and David , S. B. 1986 . Flavour formation in tissue cultures of garlic (Allium sativum L.) . Plant Cell Reports , 5 : 446 – 447 . [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Mathew , B. T. and Augusti , K. T. 1973 . Studies on the effect of allicin (Diallyl di sulphide-oxide) on alloxan diabetes 1. hypoglycaemic action and enhancement of serum insulin effect and glycogen synthesis . Indian J. Biochem. Biophys. , 10 : 209 – 212 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Meyers , J. and Simon , P. 1998 . Continuous callus production and regeneration of garlic (Allium sativum L.) using root segments from shoot tip-derived plantlets . Plant Cell Rep. , 17 : 726 – 730 . [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Milner , J. A. 1996 . Garlic: Its anticarcinogenic and antitumorigenic properties . Nutr. Rev. , 54 : S82 – S86 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Milner , J. A. 2001a . A historical perspective on garlic and cancer . J. Nutrition , 31 : 1027s – 1040s . [CSA]
   Google Scholar
• Milner , J. A. 2001b . Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis . Adv. Exp. Med. Biol. , 492 : 69 – 81 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Mohanty , B. D. , Singh , N. S. and Patwardhan , M. V. 1989 . Cytological changes associated with allicin production in garlic (Allium sativum L.) . Arch. Biochem. Biophys. , 249 : 27 – 33 . [CSA]
   Google Scholar
• Mori , H. and Nishikawa , A. 1998 . “ Naturally occurring organosulfur compounds as potential anticarcinogens ” . In Nutrition and Chemical Toxicity , Edited by: Ioannides . 285 – 299 . New York : Wiley .
   Google Scholar
• Murashige , T. and Skoog , F. 1962 . A revised medium for rapid growth and bioassays with tobacco tissue culture . Physiol Plant. , 15 : 473 – 497 . [CSA]
   Web of Science ®Google Scholar
• Nagakubo , T. , Nagasawa , A. and Ohkawa , H. 1993 . Micropropagation of garlic through in vitro bulblet formation . Plant Cell, Tissue & Org. Cult. , 32 : 175 – 183 . [CSA] [CROSSREF]
   Web of Science ®Google Scholar
• Newall , C. A. , Anderson , L. A. and Phillipson , J. D. 1996 . “ Garlic ” . In Herbal Medicines: A Guide for Health-Care Professionals , 129 – 133 . London : Pharmaceutical Press .
   Google Scholar
• Nok , A. J. , Williams , S. and Onyenekwe , P. C. 1996 . Allium sativum-induced death of African trypanosomes . Parasitology Research , 82 : 634 – 637 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Novak , F. J. 1980 . Phenotype and cytological status of plants regenerated from callus cultures of Allium sativum L . Pflanzenzucht. , 84 : 250 – 260 . [CSA]
   Google Scholar
• Novak , F. J. 1981 . Chromosomal characteristics of long-term callus cultures of Allium sativum L . Cytologia. , 46 : 371 – 379 . [CSA]
   Web of Science ®Google Scholar
• Novak , F. J. 1990 . “ Allium tissue culture ” . In Onions and allied crops , Edited by: Rabinowitch , H. D. and Brewster , J. L. Vol. 2 , 233 – 250 . Boca Raton : CRC Press .
   Google Scholar
• O'Gara , E. A. , Hill , D. J. and Maslin , D. J. 2000 . Activities of garlic oil, garlic powder and their Diallyl constituents against Helicobacter pylori . Appl. Environ. Microbiol. , 66 : 2269 – 2273 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ohaeri , O. C. 2001 . Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats . Biosci. Rep. , 21 : 19 – 24 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Patumraj , S. , Tewit , S. , Amatyakul , S. , Jariyapongskul , A. , Maneesri , S. , Kesantikul , V. and Shepro , D. 2000 . Comparative effects of garlic and Aspirin on diabetic cardiovascular complication . Drug Deliv. , 7 : 91 – 96 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Peffley , E. , Hart , M. , Wheeler , T. , Xiang , Z. , El-Sharif , A. , Dong , N. and Phillips , G. 1995 . Progress towards transformation of onion, Allium cepa and A. fistulosum via particle bombardment . Allium Improvement Newsletter , 5 : 14 – 16 . [CSA]
   Google Scholar
• Qureshi , A. A. , Abuirmeileh , N. , Din , Z. Z. , Elson , C. E. and Burger , W. C. 1983a . Inhibition of cholesterol and fatty acid biosynthesis in liver enzymes and chicken hepatocytes by polar fractions of garlic . Lipids , 18 : 343 – 348 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Qureshi , A. A. , Din , Z. Z. , Abuirmeileh , N. , Burger , W. C. , Ahmad , Y. and Elson , C. E. 1983b . Suppression of avian hepatic lipid metabolism by solvent extracts of garlic: Impact on serum lipids . J. Nutr. , 113 : 1746 – 1755 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Rahman , K. 2001 . Historical perspective on garlic and cardiovascular disease . J. Nutr. , 131 : 977 – 979 . [CSA]
   PubMed Web of Science ®Google Scholar
• Robledo-Pez , A. , Villalabos-Arambula , V. M. and Jofre-Garfias , A. E. 2000 . Efficient plant regeneration of garlic (Allium sativum L.) by root tip culture . In vitro Cell Dev. Biol. Plant , 36 : 416 – 419 . [CSA]
   Google Scholar
• Sakamoto , K. , Lawson , L. D. and Milner , J. A. 1997 . Allyl sulfides from garlic suppress the in vitro proliferation of human A549 lung tumor cells . Nutr. Cancer , 29 : 152 – 156 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Saker , M. and Sawahel , W. 1998a . Cultivar identification and detection of somaclonal variations using RAPD fingerprinting in garlic . Arab. J. Biotechnol. , 1 : 69 – 75 . [CSA]
   Google Scholar
• Saker , M. and Sawahel , W. 1998b . Origin of garlic explants govern their competence for plant regeneration . Bull. N.R.C., Egypt , 23 : 203 – 211 . [CSA]
   Google Scholar
• Salman , H. , Bergman , M. , Bessler , H. , Punsky , I. and Djaldetti , M. 1999 . Effect of garlic derivative (alliin) on peripheral blood cell immune responses . Int. J. Immunopharmacol. , 21 : 589 – 597 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Sata , S. J. , Bagatharia , B. and Thaker , V. S. 2001 . Induction of direct embryogenesis in garlic (Allium sativum.) . Methods Cell Sci. , 22 : 299 – 304 . [CSA] [CROSSREF]
   Google Scholar
• Sawahel , W. and Cove , D. 1992 . Gene transfer strategies in plants . Biotechnol. Adv. , 10 : 393 – 412 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sawahel , W. 2002 . Stable genetic transformation of garlic plants using particle bombardment . Cellular and Mol. Biol. Lett. , 7 : 49 – 59 . [CSA]
   PubMed Web of Science ®Google Scholar
• Selby , V. , Galpin , I. and Collin , H. A. 1979 . Comparison of onion plant (Allium cepa) and onion tissue culture. I. Allinase activity and flavour precursor compounds . New Phytol. , 83 : 351 – 359 . [CSA]
   Web of Science ®Google Scholar
• Sendl , A. , Schliack , M. , Loser , R. , Stanislaus , F. and Wagner , H. 1992 . Inhibition of cholesterol synthesis in vitro by extracts and isolated compounds prepared from garlic and wild garlic . Atherosclerosis , 94 : 79 – 85 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMedGoogle Scholar
• Sheela , C. G. and Augusti , K. T. 1992 . Antidiabetic effects of S-Allyl cysteine sulphoxide isolated from garlic Allium sativum. L . Indian J. Exp. Biol. , 30 : 523 – 526 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Sheela , C. G. , Kumud , K. and Augusti , K. T. 1995 . Anti-diabetic effect of onion and garlic sulfoxide amino acids in rats . Planta Medica , 61 : 356 – 357 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Sigounas , G. , Hooker , J. , Anagnostou , A. and Steiner , M. 1997 . S-Allylmercaptocysteine inhibits cell proliferation and reduces the viability of erythroleukemia, breast, and prostate cancer cell lines . Nutr. Cancer , 27 : 186 – 191 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Singh , D. V. and Shukla , N. P. 1984 . Activity on multiple resistant bacteria of garlic (Allium sativum) extract . Fitoterapia , 5 : 313 – 315 . [CSA]
   Google Scholar
• Sivam , G. B. 2001 . Protection against Helicobacter pylori and other bacterial infection by garlic . J. Nutr. , 131 : 1106s – 1108s . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Soffar , S. A. and Mokhtar , G. M. 1991 . Evaluation of the antiparasitic effect of aqueous garlic (Allium sativum) extract in hymenolepiasis nana and giardiasis . Journal of the Egyptian Society of Parasitology , 21 : 497 – 502 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Srivastava , K. C. and Tyagi , O. D. 1993 . Effects of a garlic-derived principle (ajoene) on aggregation and arachidonic acid metabolism in human blood platelets . Prostaglandins Leukot. Essent. Fatty Acids , 49 : 587 – 595 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sundaram , S. G. and Milner , J. A. 1993 . Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture . Cancer Lett. , 74 : 85 – 90 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sundaram , S. G. and Milner , J. A. 1996a . Diallyl disulfide induces apoptosis of human colon tumor cells . Carcinogenesis , 17 : 669 – 673 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Sundaram , S. G. and Milner , J. A. 1996b . Diallyl disulfide inhibits the proliferation of human tumor cells in culture . Biochem. Biophys. Acta , 1315 : 15 – 20 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Sundaram , S. G. and Milner , J. A. 1996c . Diallyl disulfide suppresses the growth of human colon tumor cell xenografts in athymic nude mice . J. Nutr. , 126 : 1355 – 1361 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Suzui , N. , Sugie , S. , Rahman , K. M. , Ohnishi , M. , Yoshimi , N. , Wakabayashi , K. and Mori , H. 1997 . Inhibitory effects of diallyl disulfide or aspirin on 2-amino-1-methyl-6- phenylimidazo [4,5-b] pyridine-induced mammary carcinogenesis in rats . Jpn. J. Cancer Res. , 88 : 705 – 711 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Swanston-Flatt , S. K. , Day , C. , Bailey , C. J. and Flatt , P. R. 1990 . Traditional plant treatment for diabetes. Studies in normal and streptozotocin diabetic mice . Diabetologia , 33 : 462 – 464 . [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Turnbull , A. , Gaplin , I. J. , Smith , J. L. and Collin , H. A. 1981 . Comparison of onion plant (Allium cepa) and onion tissue culture. IV. Effect of shoot and root morphogenesis on flavour precursor synthesis in onion tissue culture . New Phytol. , 87 : 257 – 268 . [CSA]
   Web of Science ®Google Scholar
• Venugopal , P. V. and Venugopal , T. V. 1995 . Antidermatophytic activity of garlic (Allium sativum) in vitro . International Journal of Dermatology , 34 : 278 – 279 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Walkey , D. , Webb , M. , Bolland , G. and Miller , A. 1990 . Production of virus-free garlic (Allium sativum L.) and shallot (A. ascalonicum L.) by meristem-tip culture . Hort. Sci. , 62 : 211 – 220 . [CSA]
   Google Scholar
• Weber , N. D. , Andersen , D. O. , North , J. A. , Murray , B. K. , Lawson , L. D. and Hughes , B. G. 1992 . In Vitro Virucidal Effects of Allium sativum (Garlic) Extract and Compounds . Planta Medica , 58 : 417 – 423 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Xue , H. , Araki , H. , Shi , L. and Yakuwa , T. 1991 . Somatic embryogenesis and plant regeneration in basal plate and receptacle derived callus cultures of Allium sativum L.) (In Japanese) . J. Jpn Soc. Hortic. Sci. , 60 : 627 – 634 . [CSA]
   Google Scholar
• Yeh , Y. -Y. and Liu , L. 2001 . Cholesterol-lowering effect of garlic extracts and organosulfur compounds: Human and animal studies . Journal of Nutrition , 131 : 989 – 993 . [CSA]
   PubMed Web of Science ®Google Scholar