Bioactive Compounds in Cranberries and their Biological Properties

REFERENCES

• Acquaviva , R. , Russo , A. , Galvano , F. , Galvano , G. , Barcellona , M. L. , Li Volti , G. and Vanella , A. 2003 . Cyanidin and cyanidin 3-O-β -D-glucoside as DNA cleavage protectors and antioxidants . Cell Biol.Toxicol. , 19 : 243 – 52 .
   PubMed Web of Science ®Google Scholar
• Bagchi , D. , Sen , C. K. , Bagchi , M. and Atalay , M. 2004 . Anti-angiogenic, antioxidant and anticarcinogenic properties of a novel anthocyanin-rich berry extract formula . Biochem. Trans. Biokhimiya , 69 : 79 – 80 .
   Web of Science ®Google Scholar
• Beighton , D. 2005 . The complex oral microflora of high-risk individuals and groups and its role in the caries process . Community Dent. Oral , 33 : 248 – 255 .
   PubMed Web of Science ®Google Scholar
• Bodet , C. , Chandad , F. and Grenier , D. 2007 . Inhibition of host extracellular matrix destructive enzyme production and activity by a high-molecular-weight cranberry fraction . J. Periodontal Res , 42 : 159 – 168 .
   PubMed Web of Science ®Google Scholar
• Bodet , C. , Chandad , F. and Grenier , D. 2006 . Anti-inflammatory activity of a high-molecular-weight cranberry fraction on macrophages stimulated by lipopolysaccharides from periodontopathogens . J. Dent. Res. , 85 : 235 – 239 .
   PubMed Web of Science ®Google Scholar
• Bodet , C. , Grenier , D. , Chandad , F. , Ofek , I. , Steinberg , D. and Weiss , E. I. 2008 . Potential oral health benefits of cranberry . Crit. Rev. Food Sci. , 48 : 672 – 680 .
   PubMed Web of Science ®Google Scholar
• Bohm , B. A. 1998 . “ Structural variation: The flavonoid literature ” . In Introduction to Flavonoids. , Edited by: Ravindranath , B. 5 – 284 . Amsterdam : Harwood Academic Publishers .
   Google Scholar
• Bravo , L. 1998 . Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance . Nutr. Rev. , 56 : 317 – 333 .
   PubMed Web of Science ®Google Scholar
• Burger , O. , Ofek , I. , Tabak , M. , Weiss , E. I. , Sharon , N. and Neeman , I. 2000 . A high molecular mass constituent of cranberry juice inhibits Helicobacter pylori adhesion to human gastric mucus . FEMS Immunol. Med. Mic. , 29 : 295 – 301 .
   PubMed Web of Science ®Google Scholar
• Burger , O. , Weiss , E. , Sharon , N. , Tabak , M. , Neeman , I. and Ofek , I. 2002 . Inhibition of Helicobacter pylori adhesion to human gastric mucus by a high-molecular-weight constituent of cranberry juice . Crit. Rev. Food Sci. , 42 : 279 – 84 .
   PubMed Web of Science ®Google Scholar
• Chen , H. Y. and Zuo , Y. 2007 . Identification of flavonol glycosides in American cranberry fruit . Food Chem. , 101 : 1357 – 1364 .
   Web of Science ®Google Scholar
• Chen , H. Y. , Zuo , Y. and Deng , Y. 2001 . Separation and determination of flavonoids and other phenolic compounds in cranberry juice by high-performance liquid chromatography . J. Chromatogr. A , 913 : 387 – 395 .
   PubMed Web of Science ®Google Scholar
• Cuyckens , F. and Claeys , M. 2004 . Mass spectrometry in the structural analysis of flavonoids . J. Mass Spectrom. , 39 : 1 – 15 .
   PubMed Web of Science ®Google Scholar
• Dixon , R. A. , Xie , D.-Y. and Sharma , S. B. 2005 . Proanthocyanidins - a final frontier in flavonoid research? . New Phytol. , 165 : 9 – 28 .
   PubMed Web of Science ®Google Scholar
• Duarte , S. , Gregoire , S. , Singh , A. P. , Vorsa , N. , Schaich , K. , Bowen , W. H. and Koo , H. 2006 . Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms . FEMS Microbiol. Lett. , 257 : 50 – 56 .
   PubMed Web of Science ®Google Scholar
• Escarpa , A. and Gonzales , M. C. 2001 . An overview of analytical chemistry of phenolic compounds in foods . Crit. Rev. Anal.Chem. , 31 : 57 – 139 .
   Web of Science ®Google Scholar
• Fletcher , A. C. , Porter , L. J. , Haslam , E. and Gupta , R. K. 1977 . Plant proanthocyanidins. Part 3. Conformational and configurational studies of natural procyanidins . J. Chem. Soc., Perk. T. 1 , 14 : 1628 – 1637 .
   Google Scholar
• Foo , L. Y. , Lu , Y. , Howell , A. B. and Vorsa , N. 2000a . A-type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli . J. Nat. Prod. , 63 : 1225 – 228 .
   PubMed Web of Science ®Google Scholar
• Foo , L. Y. , Lu , Y. , Howell , A. B. and Vorsa , N. 2000b . The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichiacoli in vitro . Phytochemistry , 54 : 173 – 81 .
   PubMed Web of Science ®Google Scholar
• Frankel , E. N. and Meyer , A. S. 2000 . The problems of using one-dimensional methods to evaluate multifunctional food and biological antioxidants . J. Sci. Food Agr. , 80 : 1925 – 41 .
   Web of Science ®Google Scholar
• Gee , J. M. and Johnson , I. T. 2001 . Polyphenolic compounds: Interactions with the gut and implications for human health . Curr. Med. Chem. , 8 : 1245 – 1255 .
   PubMed Web of Science ®Google Scholar
• Girard , K. K. and Sinha , N. 2006 . “ Cranberry, blueberry, currant, and gooseberry ” . In Handbook of Fruits and Fruit Processing. , Edited by: Hui , Y. H. 369 – 390 . Ames, Iowa : Blackwell Publishing .
   Google Scholar
• Gu , L. , Kelm , M. A. , Hammerstone , J. F. , Beecher , G. , Holden , J. , Haytowitz , D. , Gebhardt , S. and Prior , R. L. 2004 . Concentrations of proanthocyanidins in common foods and estimations of normal consumption . J. Nutr. , 134 : 613 – 617 .
   PubMed Web of Science ®Google Scholar
• Häkkinen , S. , Heinonen , M. , Karenlampi , S. , Mykkanen , H. , Ruuskanen , J. and Torronen , R. 1999 . Screening of selected flavonoids and phenolic acids in 19 berries . Food Res. Int. , 32 : 345 – 353 .
   Web of Science ®Google Scholar
• Halliwell , B. 1999 . Establishing the significance and optimal intake of dietary antioxidants: The biomarker concept . Nutr. Rev. , 57 : 104 – 13 .
   PubMed Web of Science ®Google Scholar
• Hammerstone , J. F. , Lazarus , S. A. and Schmitz , H. H. 2000 . Procyanidin content and variation in some commonly consumed foods . J. Nutr. , 130 : 2086S – 2092S .
   PubMed Web of Science ®Google Scholar
• Harborne , J. B. 1964 . Biochemistry of Phenolic Compounds , New York : Academic Press .
   Google Scholar
• Harborne , J. B. 1998 . Phytochemical Method: A Guide to Modern Technique of Plant Analysis , London : Chapman and Hall .
   Google Scholar
• Haslam , E. 1998 . Practical Polyphenolics from Structure to Molecular Recognition and Physiological Action , Cambridge, , U.K. : Cambridge University Press .
   Google Scholar
• Hawker , J. S. , Buttrose , M. S. , Soeffky , A. and Possigham , J. V. 1972 . A simple method for demonstrating macroscopically the location of polyphenolic compounds in grape berries . Vitis , 11 : 189 – 192 .
   Google Scholar
• He , X. and Lui , R. H. 2006 . Cranberry phytochemicals: Isolation, structure elucidation, and their antiproliferative and antioxidant activities . J. Agr. Food Chem. , 54 : 7069 – 74 .
   PubMed Web of Science ®Google Scholar
• Heinonen , M. 2007 . Antioxidant activity and antimicrobial effect of berry phenolics - a Finnish perspective . Mol. Nutr. Food Res. , 51 : 684 – 91 .
   PubMed Web of Science ®Google Scholar
• Higdon , J. 2007 . An Evidence-Based Approach to Dietary Phytochemicals , New York : Thieme Medical Publishers .
   Google Scholar
• Hollman , P. C.H. and Katan , M. B. 1997 . Absorption, metabolism and health effects of dietary flavonoids in man . Biomed. Pharmacother. , 51 : 305 – 310 .
   PubMed Web of Science ®Google Scholar
• House , W. A. 1999 . Trace element bioavailability as exemplified by iron and zinc . Field Crop. Res. , 60 : 115 – 141 .
   Web of Science ®Google Scholar
• Howell , A. B. , Reed , J. D. , Krueger , C. G. , Winterbottom , R. , Cunningham , D. G. and Leahy , M. 2005 . A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity . Phytochemistry , 66 : 2281 – 91 .
   PubMed Web of Science ®Google Scholar
• Huang , D. , Ou , B. and Prior , R. L. 2005 . The chemistry behind antioxidant capacity assays . J. Agr. Food Chem. , 53 : 1841 – 56 .
   PubMed Web of Science ®Google Scholar
• Iwashina , T. 2000 . The structure and distribution of the flavonoids in plants . J. Plant Res. , 113 : 287 – 299 .
   Web of Science ®Google Scholar
• Jepson , R. G. and Graig , J. 2008 . Cranberries for preventing urinary tract infections . Cochrane Db. Syst. Rev. (Online) , 1 : CD001321
   Google Scholar
• Kähkönen , M. P. , Hopia , A. I. and Heinonen , M. 2001 . Berry phenolics and their antioxidant activity . J. Agr. Food Chem. , 49 : 4076 – 4082 .
   PubMed Web of Science ®Google Scholar
• Kaponen , J. M. , Happonen , A. M. , Mattila , P. H. and Törrönen , A. 2007 . Contents of anthocyanins and ellagitannins in selected foods consumed in Finland . J. Agr. Food Chem , 55 : 1612 – 1619 .
   PubMed Web of Science ®Google Scholar
• King , A. and Young , G. 1999 . Characteristics and occurrence of phenolic phytochemicals . J. Am. Diet. Assoc. , 99 : 213 – 218 .
   PubMedGoogle Scholar
• Kolodziej , H. , Haberland , C. , Woerdenbag , H. J. and Konings , A. W.T. 1995 . Moderate cytotoxicity of proanthocyanidins to human tumour cell lines . Phytother. Res. , 9 : 410 – 15 .
   Web of Science ®Google Scholar
• Kondo , M. 2006 . Phytochemical studies of extracts from cranberry (Vaccinium macrocarpon) with anticancer, antifungal and cardioprotective properties , North Dartmouth, MA : University of Massachusetts Dartmouth .
   Google Scholar
• Kren , V. and Martinkové , L. 2001 . Glycosides in medicine: The role of glycosidic residue in biological activity . Curr. Med. Chem. , 8 : 1303 – 1328 .
   PubMed Web of Science ®Google Scholar
• Krneger , C. G. , Vestling , M. M. and Reed , J. D. 2004 . “ Matrix–assisted laser desorption/ionization time–of–flight mass spectrometry of anthocyania–polyflovan–3–01 oligomers in cranberry fruit (Vaccinium macrocarpon, Ait) and spedy dried cranberry juice ” . In Red wine colour: Revealing the Mysteries. , Edited by: Waterhouse , A. L. and Kenedy , J. A. 232 – 246 . Washington, D.C. : American Chemical Society . ACS Symposium Series, vol. 886.
   Google Scholar
• Lazarus , S. A. , Hammerstone , J. F. , Adamson , G. E. and Schmitz , H. H. 2001 . “ HPLC/MS analysis of proanthocyanidins in food and beverages ” . In Methods in Enzymology , Edited by: Parker , L. Vol. 335 , 46 – 55 . San Diego, CA : Academic Press .
   Google Scholar
• Lazze , M. C. , Pizzala , R. , Savio , M. , Stivala , L. A. , Prosperi , E. and Bianchi , L. 2003 . Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells . Mutat. Res.-Gen. Tox. En. , 535 : 103 – 15 .
   PubMed Web of Science ®Google Scholar
• Lee , H. S. 2000 . “ HPLC analysis of phenolic compounds ” . In Food Analysis by HPLC. , Edited by: Nollet , L. M.L. 775 – 824 . New York : Marcel Dekker .
   Google Scholar
• Lei , Z. , Jervis , J. and Helm , R. F. 2001 . Use of methanolysis for the determination of total ellagic and gallic acid contents of wood and food products . J. Agr. Food Chem. , 49 : 1165 – 1168 .
   PubMed Web of Science ®Google Scholar
• Leitao , D. P.S. , Polozello , A. C.M. , Ito , I. Y. and Spadaro , A. C. 2005 . Antibacterial screening of anthocyanic and proanthocyanic fractions from cranberry juice . J. Med. Food , 8 : 36 – 40 .
   PubMed Web of Science ®Google Scholar
• Leung , J. , Fenton , T. W. , Mueller , M. M. and Clandinin , D. R. 1979 . Condensed tannins of rapeseed meal . J. Food Sci. , 44 : 1313 – 1316 .
   Web of Science ®Google Scholar
• Lin , L.-Z. and Harnly , J. M. 2007 . A screening method for the identification of glycosylated flavonoids and other phenolic compounds using a standard analytical approach for all materials . J. Agr. Food Chem. , 55 : 1084 – 1096 .
   PubMed Web of Science ®Google Scholar
• Lugasi , A. and Hovari , J. 2000 . Flavonoid aglycons in foods of plant origin I. Vegetables . Acta Aliment. Hung. , 29 : 345 – 352 .
   Web of Science ®Google Scholar
• Määttä-Riihinen , K. R. , Kähkönen , M. P. , Törrönen , A. R. and Heinonen , I. M. 2005 . Catechins and procyanidins in berries of Vaccinium species and their antioxidant activity . J. Agr. Food Chem. , 53 : 8485 – 8491 .
   PubMed Web of Science ®Google Scholar
• Macheix , J. J. and Fleuriet , A. 1998 . “ Phenolic acids in fruits ” . In Flavonoids in Health and Disease , Edited by: Rice-Evans , C. A. and Packer , L. 35 – 60 . New York : Marcel Dekker .
   Google Scholar
• Macheix , J. J. , Fleuriet , A. and Billot , J. 1990 . Fruit Phenolics , Boca Raton, FL : CRC Press .
   Google Scholar
• Marles , M. A.S. , Gruber , M. Y. , Scoles , G. J. and Muir , A. D. 2003 . Pigmentation in the developing seed coat and seedling leaves of Brassica carinata is controlled at the dihydroflavonol reductase locus . Phytochemistry , 62 : 663 – 672 .
   PubMed Web of Science ®Google Scholar
• Marwan , A. G. and Nagel , C. W. 1986 . Characterization of cranberry benzoates and their antimicrobial properties . J. Food Sci. , 51 : 1069 – 1070 .
   Web of Science ®Google Scholar
• Mayorga , H. , Knapp , H. , Winterhalter , P. and Duque , C. 2001 . Glycosidically bound flavor compounds of cape gooseberry (Physalis peruviana L.) . J. Agr. Food Chem. , 49 : 1904 – 1908 .
   PubMed Web of Science ®Google Scholar
• Merken , H. M. and Beecher , G. R. 2000a . Measurement of food flavonoids by high-performance liquid chromatography: A review . J. Agr. Food Chem. , 48 : 577 – 599 .
   PubMed Web of Science ®Google Scholar
• Merken , H. M. and Beecher , G. R. 2000b . Liquid chromatographic method for the separation and quantification of prominent flavonoid aglycons . J. Chromatogr. , 897 : 177 – 184 .
   PubMed Web of Science ®Google Scholar
• Mitscher , L. A. , Telikepalli , H. , McGhee , E. and Shankel , D. M. 1996 . Natural antimutagenic agents . Mutat. Res. – Fund. Mol. M. , 350 : 143 – 52 .
   PubMed Web of Science ®Google Scholar
• Neto , C. C. , Amoroso , J. W. and Liberty , A. M. 2008 . Anticancer activities of cranberry phytochemicals: An update . Mol. Nutr. Food Res. , 52 : S18 – S27 .
   PubMed Web of Science ®Google Scholar
• Neto , C. C. 2007 . Cranberry and its phytochemicals: A review of in vitro anticancer studies . J. Nutr. , 137 : 186S – 193S .
   PubMed Web of Science ®Google Scholar
• Neto , C. C. , Krueger , C. G. , Lamoureaux , T. L. , Kondo , M. , Vaisberg , A. J. , Hurta , R. A.R. , Curtis , S. , Matchett , M. D. and Yeung , H. 2006 . MALDI-TOF MS characterization of proanthocyanidins from cranberry fruit (Vaccinium macrocarpon) that inhibit tumor cell growth and matrix metalloproteinase expression in vitro . J. Sci. Food Agr. , 86 : 18 – 25 .
   Web of Science ®Google Scholar
• Nijveldt , R. J. , Van Nood , E. , Van Hoorn , D. E.C. , Boelens , P. G. , Van Norren , K. and Van Leeuwen , P. A.M. 2001 . Flavonoids: A review of probable mechanisms of action and potential applications . Am. J. Clin. Nutr. , 7 : 418 – 425 .
   Google Scholar
• Nozzolillo , C. and Ricciardi , L. 1992 . “ Proanthocyanidin content of broad bean seeds: relationship of seed coat color ” . In Plant Polyphenols: Synthesis, Properties, Significance , Edited by: Hemingway , R. W. and Laks , P. E. Vol. 59 , 911 – 914 . New York : Plenum Press .
   Google Scholar
• Palcanis , K. G. , Larjava , I. K. , Wells , B. R. , Suggs , K. A. , Landis , J. R. , Chadwick , D. E. and Jeffcoat , M. K. 1992 . Elastase as an indicator of periodontal disease progression . J. Periodontol. , 63 : 237 – 242 .
   PubMed Web of Science ®Google Scholar
• Plumb , G. W. , De Pascual-Teresa , S. , Santos-Buelga , C. , Cheynier , V. and Williamson , G. 1998 . Antioxidant properties of catechins and proanthocyanidins: Effect of polymerisation, galloylation and glycosylation . Free Radical Res. , 29 : 351 – 358 .
   PubMed Web of Science ®Google Scholar
• Porter , M. L. , Krueger , C. G. , Wiebe , D. A. , Cunningham , D. G. and Reed , J. D. 2001 . Cranberry proanthocyanidins associate with low-density lipoprotein and inhibit in vitro Cu2 +-induced oxidation . J. Sci. Food Agr. , 81 : 1306 – 13 .
   Web of Science ®Google Scholar
• Porter , L. J. 1994 . “ Flavans and proanthocyanidins ” . In The Flavonoids: Advances in research since 1986 , Edited by: Harborne , J. B. 23 – 53 . London : Chapman and Hall .
   Google Scholar
• Price , K. R. , Prosser , T. , Richetin , A. M.F. and Rhodes , M. J.C. 1999 . A comparison of the flavonol content and composition in dessert, cooking and cider-making apples; distribution within the fruit and effect of juicing . Food Chem. , 66 : 489 – 494 .
   Web of Science ®Google Scholar
• Puupponen-Pimia , R. , Nohynek , L. , Hartmann-Schmidlin , S. , Kähkönen , M. , Heinonen , M. , Määttä-Riihinen , K. and Oksman-Caldentey , K.-M. 2005 . Berry phenolics selectively inhibit the growth of intestinal pathogens . J. Appl. Microbiol. , 98 : 991 – 1000 .
   PubMed Web of Science ®Google Scholar
• Ramirez-Tortosa , C. , Andersen , O. M. , Gardner , P. T. , Morrice , P. C. , Wood , S. G. , Duthie , S. J. , Collins , A. R. and Duthie , G. G. 2001 . Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats . Free Radical. Bio. Med. , 31 : 1033 – 37 .
   PubMed Web of Science ®Google Scholar
• Ramos , S. , Alia , M. , Bravo , L. and Goya , L. 2005 . Comparative effects of food-derived polyphenols on the viability and apoptosis of a human Hepatoma Cell Line (HepG2) . J. Agr. Food Chem. , 53 : 1271 – 80 .
   PubMed Web of Science ®Google Scholar
• Rice-Evans , C. 2001 . Flavonoid antioxydants . Curr. Med. Chem. , 8 : 797 – 807 .
   PubMed Web of Science ®Google Scholar
• Rijke , E. , Out , P. , Niessen , W. M.A. , Ariese , F. , Gooijer , C. and Brinkman , U. A.T. 2006 . Analytical separation and detection methods for flavonoids . J. Chromatogr. A , 1112 : 31 – 63 .
   PubMed Web of Science ®Google Scholar
• Robards , K. and Antolovich , M. 1997 . Analytical chemistry of fruit bioflavonoids: A review . Analyst , 2 : 11R – 34R .
   Web of Science ®Google Scholar
• Roy , S. , Khanna , S. , Alessio , H. M. and Vider , J. 2002 . Antiangiogenic property of edible berries . Free Radic. Res. , 36 : 1023 – 1031 .
   PubMed Web of Science ®Google Scholar
• Ruel , G. and Couillard , C. 2007 . Evidences of the cardioprotective potential of fruits: The case of cranberries . Mol. Nutr. Food Res. , 51 : 692 – 701 .
   PubMed Web of Science ®Google Scholar
• Sakakibara , H. , Honda , Y. , Nakagawa , S. , Ashida , H. and Kanazawa , K. 2003 . Simultaneous determination of all polyphenols in vegetables, fruits, and teas . J. Agr. Food Chem. , 51 : 571 – 581 .
   PubMed Web of Science ®Google Scholar
• Seeram , N. P. and Heber , D. 2007 . Impact of berry phytochemicals on human health: Effects beyond antioxidant . ACS Sym. Ser. , 956 : 326 – 336 .
   Google Scholar
• Seeram , N. P. , Adams , L. S. , Hardy , M. L. and Heber , D. 2004 . Total cranberry extract versus its phytochemical constituents: Antiproliferative and synergistic effects against human tumor cell lines . J. Agr. Food Chem. , 52 : 2512 – 17 .
   PubMed Web of Science ®Google Scholar
• Shahidi , F. and Naczk , M. 1995 . Food Phenolics: Sources, Chemistry, Effects, Applications , Lancaster, PA : Technomic Publishing Company .
   Google Scholar
• Sharon , N. and Ofek , I. 2002 . Fighting infectious diseases with inhibitors of microbial adhesion to host tissues . Crit. Rev. Food Sci. , 42 : 267 – 72 .
   PubMed Web of Science ®Google Scholar
• Shirley , B. , Kubasek , W. L. , Storz , G. , Bruggemann , E. , Koorneef , M. , Ausubel , F. M. and Goodman , H. M. 1995 . Analysis of Arabidopsis mutants deficient in flavonoid biosynthesis . Plant J. , 8 : 659 – 671 .
   PubMed Web of Science ®Google Scholar
• Shirley , B. W. , Hanley , S. and Goodman , H. M. 1992 . Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent test mutations . Plant Cell , 4 : 333 – 347 .
   PubMed Web of Science ®Google Scholar
• Sorsa , T. , Suomalainen , K. and Uitto , V.-J. 1990 . The role of gingival crevicular fluid and salivary interstitial collagenases in human periodontal diseases . Arch. Oral. Biol. , 35 ( Suppl. 1 ) : S193 – S196 .
   Google Scholar
• Sorsa , T. , Tjäderhane , L. and Salo , T. 2004 . Matrix metalloproteinases (MMPs) in oral diseases . Oral Dis. , 10 : 311318
   Web of Science ®Google Scholar
• Stafford , H. A. 1990 . Flavonoid Metabolism , Boca Raton, FL : CRC Press .
   Google Scholar
• Strack , D. and Wray , V. 1994 . “ The anthocyanins ” . In The Flavonoids: Advances in research since 1986. , Edited by: Harborne , J. B. 324 – 351 . London, U.K. : Chapman and Hall .
   Google Scholar
• Szajdek , A. and Borowska , E. J. 2008 . Bioactive compounds and health-promoting properties of berry fruits: A review . Plant Foods Hum. Nutr. , 63 : 147 – 156 .
   PubMed Web of Science ®Google Scholar
• Teel , R. W. , Babcock , M. S. , Dixit , R. and Stoner , G. D. 1986 . Ellagic acid toxicity and interactions with benzo[A]pyrene and benzo[A]pyrene 7,8-dihydrodiol in human bronchial epithelial cells . Cell Biol. Toxicol. , 2 : 53 – 62 .
   PubMed Web of Science ®Google Scholar
• Tomas-Barberan , F. A. and Clifford , M. N. 2000 . Review: Dietary hydroxybenzoic acid derivatives – nature, occurrence and dietary burden . J. Sci. Food Agr. , 80 : 1024 – 1032 .
   Web of Science ®Google Scholar
• U.S. Department of Agriculture, National Nutrient Database . 2004 . USDA Database for the proanthocyanidin content of selected foods www.nal.usda.gov/fnic/foodcomp/Data/PA/PA
   Google Scholar
• U.S. Department of Agriculture, National Nutrient Database, Release #2 . 2007 . Database for the flavonoid content of selected foods www.nal.usda.gov/fnic/foodcomp
   Google Scholar
• Ursini , F. , Rapuzzi , I. , Toniolo , R. , Tubaro , F. and Bontempelli , G. 2001 . Characterization of antioxidant effect of procyanidins . Method. Enzymol. , 335 : 338 – 350 .
   PubMed Web of Science ®Google Scholar
• Vattem , D. A. and Shetty , K. 2003 . Ellagic acid production and phenolic antioxidant activity in cranberry pomace (Vaccinium macrocarpon) mediated by Lentinus edodes using a solid-state system . Proc. Biochem. , 39 : 367 – 379 .
   Web of Science ®Google Scholar
• Vattem , D. A. and Shetty , K. 2005 . “ Functional phytochemicals from cranberries: Their mechanism of action and strategies to improve functionality ” . In Food Biotechnology, , 2nd Ed. , Edited by: Shetty , K. , Pometto , T. , Paliyath , A. and Levin , R. E. 789 – 823 . New York : Marcel Dekker Inc .
   Google Scholar
• Vattem , D. A. , Ghaedian , R. and Shetty , K. 2005a . Enhancing health benefits of berries through phenolic antioxidant enrichment: Focus on cranberry . Asia Pac. J. Clin. Nutr. , 14 : 120 – 30 .
   PubMed Web of Science ®Google Scholar
• Vattem , D. A. , Lin , Y.-T. , Ghaedian , R. and Shetty , K. 2005b . Cranberry synergies for dietary management of Helicobacter pylori infections . Process Biochem. , 40 : 1583 – 1592 .
   Web of Science ®Google Scholar
• Vinson , J. A. , Bose , P. , Proch , J. , Al Kharrat , H. and Samman , N. 2008 . Cranberries and cranberry products: powerful in vitro, ex vivo, and in vivo sources of antioxydants . J. Agr. Food Chem. , 56 : 5884 – 5891 .
   PubMed Web of Science ®Google Scholar
• Wang , S. Y. and Jiao , H. 2000 . Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen . J. Agr. Food Chem. , 48 : 5677 – 84 .
   PubMed Web of Science ®Google Scholar
• Weiss , E. I. , Lev-Dor , R. , Kashamn , Y. , Goldhar , J. , Sharon , N. and Ofek , I. 1998 . Inhibiting interspecies coaggregation of plaque bacteria with a cranberry juice constituent . J. Am. Dent. Assoc. , 129 : 1719 – 23 .
   PubMed Web of Science ®Google Scholar
• Weiss , E. L. , Lev-Dor , R. , Sharon , N. and Ofek , I. 2002 . Inhibitory effect of a high-molecular-weight constituent of cranberry on adhesion of oral bacteria . Crit. Rev. Food Sci. , 42 : 285 – 92 .
   PubMed Web of Science ®Google Scholar
• Wildanger , W. and Herrmann , K. 1973 . The phenolics of fruits. II. The flavonols of fruits . Z. Lebensm. Unters. For. , 151 : 103 – 108 .
   Google Scholar
• Willet , W. C. 2001 . Eat, drink, and be healthy: The Harvard Medical School guide to healthy eating , New York : Simon and Schuster .
   Google Scholar
• Wu , X. and Prior , R. L. 2005 . Systematic identification and characterization of anthocyanins by HPLC-ESI-MS-MS in common foods in the US - Fruits and berries . J. Agr. Food Chem. , 53 : 2589 – 2599 .
   PubMed Web of Science ®Google Scholar
• Wu , X. , Gu , L. , Prior , R. L. and McKay , S. 2004 . Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity . J. Agr. Food Chem. , 52 : 7846 – 56 .
   PubMed Web of Science ®Google Scholar
• Yan , X. , Murphy , B. T. , Hammond , G. B. , Vinson , J. A. and Neto , C. C. 2002 . Antioxidant activities and antitumor screening of extracts from cranberry fruit (Vaccinium macrocarpon) . J. Agr. Food Chem. , 50 : 5844 – 9 .
   PubMed Web of Science ®Google Scholar
• Zafriri , D. , Ofek , I. , Adar , R. , Pocino , M. and Sharon , N. 1989 . Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated Escherichia coli to eucaryotic cells . Antimicrob. Agents Ch. , 33 : 92 – 98 .
   PubMed Web of Science ®Google Scholar
• Zhang , Z. , Hamilton , S. M. , Stewart , C. , Strother , A. and Teel , R. W. 1993 . Inhibition of liver microsomal cytochrome p450 activity and metabolism of the tobacco-specific nitrosamine NNK by capsaicin and ellagic acid . Anticancer Res. , 13 : 2341 – 46 .
   PubMed Web of Science ®Google Scholar
• Zheng , W. and Wang , S. Y. 2003 . Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries . J. Agr. Food Chem. , 51 : 502 – 509 .
   PubMed Web of Science ®Google Scholar