A Review on Aflatoxin Contamination and Its Implications in the Developing World: A Sub-Saharan African Perspective

REFERENCES

• Adebajo , L. O. 1993 . Survey of aflatoxins and ochratoxin A in stored tubers of Cyperus esculentus L . Mycopathologia , 124 : 41 – 46 .
   PubMed Web of Science ®Google Scholar
• Adhikari , M. , Ramjee , G. and Berjark , P. 1994 . Aflatoxin, kwarshiorkor and morbidity . Nat.Toxins. , 2 : 13
   Google Scholar
• Akano , D. A. and Atanda , O. O. 1990 . The present level of aflatoxins in Nigerian groundnut cake (‘kulikuli’) . Lett. Appl. Microbiol. , 10 : 187 – 189 .
   Web of Science ®Google Scholar
• Amoa-Awua , W. K. , Ngunjiri , P. , Anlobe , J. , Kpodo , K. , Halm , M. , Hayford , A. E. and Jakobsen , M. 2007 . The effect of applying GMP and HACCP to traditional food processing at a semi-commercial kenkey production plant in Ghana . Food Control , 18 ( 11 ) : 1449 – 1457 .
   Web of Science ®Google Scholar
• Amyot , J. 1983 . Social and economic aspect of dryer use for paddy and other agricultural produce in Thailand , Thailand : Chulalongkorn University Social Research Institute and International Development Research Center .
   Google Scholar
• Anonymous . 2006 . Personal communication. Food poisoning deaths still baffle Ukambani Residents
   Google Scholar
• AOAC . 1995 . Official Methods of Analysis of AOAC International Edited by: Cunniff , P. 1 – 49 . Arlington, Virginia , , United States Sixteenth edition, Vol. 2. Chapter 49
   Google Scholar
• AOAC Official method 968.22 . 2000 . Official Methods of Analysis of AOAC International, Seventeenth edition , Edited by: Horwitz , W. 9 MA , , USA : AOAC International . Chap. 49
   Google Scholar
• Arranz , I. , Baeyens , W. R. G. , Van Der Weken , G. , De Saeger , S. and Van Peteghem , C. 2004 . Review: HPLC determination of fumonisin mycotoxins . Crit. Rev. Food Sci. Nutr. , 44 : 195 – 203 .
   PubMed Web of Science ®Google Scholar
• Atehnkeng , J. , Ojiambo , P. S. , Donner , M. , Ikotun , T. , Sikora , R. A. , Cotty , P. J. and Bandyopadhyay , R. 2008a . Distribution and toxigenicity of Aspergillus species isolated from maize kernels from three agro-ecological zones in Nigeria . Int. J. Food Microbiol. , 122 : 74 – 84 .
   PubMed Web of Science ®Google Scholar
• Atehnkeng , J. , Ojiambo , P. S. , Ikotun , T. , Sikora , R. A. , Cotty , P. J. and Bandyopadhyay , R. 2008b . Evaluation of atoxigenic isolates of Aspergillus flavus as potential biocontrol agents for aflatoxin in maize . Food Addit. Contam.: Part A , 25 : 1266 – 1273 .
   Google Scholar
• Atukwase , A. , Kaaya , A. N. and Muyanja , C. 2009 . Factors associated with fumonisin contamination of maize in Uganda . J. Sci. Food Agric. , 89 : 2393 – 2398 .
   Web of Science ®Google Scholar
• Avantaggiato , G. , Solfrizzo , M. and Visconti , A. 2005 . Recent advances on the use of adsorbent materials for detoxification of Fusarium mycotoxins . Food Addit. Contam. , 22 : 379 – 388 .
   PubMed Web of Science ®Google Scholar
• Awuah , R. T. and Ellis , W. O. 2002 . Effects of some groundnut packaging methods and protection with Ocimum and Syzygium powders on kernel infection by fungi . Mycopathologia , 154 : 26 – 29 .
   Web of Science ®Google Scholar
• Azziz-Baumgartner , E. , Lindblade , K. , Gieseker , K. , Rogers , S. , Kieszak , S. , Njapau , H. , Schleicher , R. , McCoy , L. , Misore , A. , DeCock , K. , Rubin , C. and Slutsker , L. 2005 . Aflatoxin investive group. Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004 . Environ. Health Pers. , 113 : 1779 – 1783 .
   PubMed Web of Science ®Google Scholar
• Bagley , E. B. 1979 . Decontamination of corn containing aflatoxin by treatment with ammonia . J. Am. Oil Chem. Soc. , 56 : 808 – 811 .
   Web of Science ®Google Scholar
• Bankole , S. A. , Ogunsanwo , B. M. and Eseigbe , D. A. 2005 . Aflatoxins in Nigerian dry-roasted groundnuts . Food Chem. , 89 : 503 – 506 .
   Web of Science ®Google Scholar
• Bankole , S. A. and Mabekoje , O. O. 2004 . Mycoflora and occurrence of aflatoxin B1 in dried yam chips from markets in Ogun and Oyo States, Nigeria . Mycopathologia , 157 : 111 – 115 .
   PubMed Web of Science ®Google Scholar
• Bankole , S. A. and Eseigbe , D. A. 1996 . Occurrence of mycoflora and aflatoxins in marketed tiger nut . Crop Res. , 11 : 219 – 223 .
   Google Scholar
• Baributsa , D. , Lowenberg-DeBoer , J. , Murdock , L. and Moussa , D. 2010 . Profitable chemical-free cowpea storage technology for smallholder farmers in Africa: Opportunities and challenges , Proceeding of 10th International Working Conference on Stored Product Protection (IWSSP), Estoril- Portugal, 27 June–2 July 2010 .
   Google Scholar
• Barry , D. , Widstrom , M. W. , Darrah , L. L. , McMilliam , W. W. , Riley , T. J. , Scott , G. E. and Lillehoj , E. B. 1992 . Maize ear damage by insects in relation to genotype and aflatoxin contamination in preharvest maize grain . J. Econ. Entomol. , 85 : 2492 – 2495 .
   Web of Science ®Google Scholar
• Barug , D. , Van Egmond , H. , Lpez-Garcia , R. , Van Osenbruggen , T. and Visconti , A. 2003 . Meeting the Mycotoxins Menace , The Netherlands : Wageningen Academic Publishers .
   Google Scholar
• Beti , J. A. , Phillips , T. W. and Smalley , E. B. 1995 . Effect of maize weevils (Coleoptera: Curculionidae) on production of aflatoxin B1 by Aspergillus flavus in stored corn . J. Econ. Entomol. , 88 : 1776 – 1782 .
   PubMed Web of Science ®Google Scholar
• Bhat , R. V. and Vasanthi , S. 2003 . Mycotoxin food safety risks in developing countries. Food safety in food security and food trade Vision 2020 for food, agriculture and environment, Focus 10, brief 3 of 17. pp. 1–2
   Google Scholar
• Bhatnagar , D. , Cary , J. W. , Ehrlich , K. , Yu , J. and Cleveland , T. E. 2006 . Understanding the genetics of regulation of aflatoxin production and Aspergillus flavus development . Mycopathologia. , 162 : 155 – 166 .
   PubMed Web of Science ®Google Scholar
• Bock , C. H. , Mackey , B. and Cotty , P. J. 2004 . Population dynamics of Aspergillus flavus in the air of an intensively cultivated region of south-west Arizona . Plant Pathol. , 53 : 422 – 433 .
   Web of Science ®Google Scholar
• Bondy , G. S. and Pestka , J. J. 2000 . Immunomodulation by fungal toxins . J. Toxicol. Environ. Health, Part B , 3 : 109 – 143 .
   PubMed Web of Science ®Google Scholar
• Bowen , K. L. and Mack , T. P. 1991 . Lesser cornstalk borer and aflatoxins: Double trouble for peanut growers . Highlights Agric. Res. Alabama Agric. Exp. Station , 38 : 3
   Google Scholar
• Brera , C. , Catano , C. , De Santis , B. , Debegnach , F. , De Giacomo , M. , Pannunzil , E. and Miraglia , M. 2006 . Effect of industrial processing on the distribution of aflatoxins and zearalenone in corn-milling fractions . J. Agric. Food Chem. , 54 : 5014 – 5019 .
   PubMed Web of Science ®Google Scholar
• Broberg , M. 2009 . European food safety regulation and the developing countries: Regulatory problems and possibilities , 44 Denmark : Working paper 2009:09, Danish Institute for International Studies, DIIS .
   Google Scholar
• CAST . 1989 . Mycotoxins: Economic and health risks , IA : Council for Agricultural Science and Technology Ammes .
   Google Scholar
• CEC (Commission of the European Communities) . 1991 . EC directive 91/126. 13.02.1991 . Off. J. EC. , L 60 : 17
   Google Scholar
• CEC (Commission of the European Communities) . 1998 . EC directive 98/1525.16.07.1998 . Off. J. EC. , L 201 : 43
   Google Scholar
• CEC (Commission of the European Communities) . 2001 . EC directive 2001/466.08.03.2001 . Off. J. EC. , L 77 : 1
   Google Scholar
• Champeil , A. , Fourbet , J. F. , Dore , T. and Rossignol , L. 2004 . Influence of cropping system of Fusarium head blight and mycotoxin levels in winter wheat . Crop Protect. , 23 : 531 – 537 .
   Web of Science ®Google Scholar
• Chang , P. K. , Ehrlich , K. C. and Hua , S. S. 2006 . Cladal relatedness among Aspergillus oryzae isolates and Aspergillus flavus S and L Morphotype isolates . Int. J. Food Microbiol. , 108 : 172 – 177 .
   PubMed Web of Science ®Google Scholar
• Chao , T. C. , Maxwell , S. M. and Wong , S. Y. 1991 . An outbreak of aflatoxicosis and boric acid poisoning in Malaysia: A clinicopathological study . J. Pathol. , 164 : 225 – 333 .
   PubMed Web of Science ®Google Scholar
• Charmley , L. L. and Prelusky , D. B. 1995 . Decontamination of Fusarium mycotoxins . Appl. Environ. Microbiol. , 1 : 421 – 435 .
   Google Scholar
• Chauhan , Y. S. , Wright , G. C. and Rachaputi , N. C. 2008 . Modelling climatic risks of aflatoxin contamination in maize . Aust. J. Exp. Agric. , 48 : 358 – 366 .
   Google Scholar
• ChemIDPlus Lite . 2010 . United States National Library of Medicine Available at: http://chem.sis.nlm.nih.gov/chemidplus/ProxyServlet?objectHandle=Search&actionHandle=getAll3DMViewFiles&nextPage=jsp%2Fcommon%2FChemFull.jsp%3FcalledFrom%3Dlite&chemid=0001162658&formatType=_3D) Accessed January 10, 2010
   Google Scholar
• Christensen , C. M. 1973 . Loss of viability in storage: Mycoflora . Seed Sci. Technol. , 1 : 547 – 562 .
   Google Scholar
• Christensen , H. R. , Yu , F. Y. and Chu , F. S. 2000 . Development of a polyclonal antibody-based sensitive enzyme-linked immunosorbent assay for fumonisin B4 . J. Agric.Food Chem. , 48 : 1977 – 1984 .
   PubMed Web of Science ®Google Scholar
• Cleveland , T. E. , Dowd , P. F. , Desjardins , A. E. , Bhatnagar , D. and Cotty , P. J. 2003 . United States Department of Agriculture-agricultural research service on pre-harvest prevention of mycotoxins and mycotoxigenic fungi in US crops . Pest Manage. Sci. , 59 : 629 – 642 .
   PubMed Web of Science ®Google Scholar
• Coallier-Ascah , J. and Idziak , E. S. 1985 . Interaction between Streptococcus lactis and Aspergillus flavus on production of aflatoxin . Appl. Environ. Microbiol. , 49 : 163 – 167 .
   PubMed Web of Science ®Google Scholar
• Cotty , P. J. and Jaime-Garcia , R. 2007 . Influences of climate on aflatoxin producing fungi and aflatoxin contamination . Int. J. Food Microbiol. , 119 : 109 – 115 .
   PubMed Web of Science ®Google Scholar
• Cotty , P. J. and Mellon , J. E. 2006 . Ecology of aflatoxin-producing fungi and biocontrol of aflatoxin contamination . Mycotoxin Res. , 22 : 110 – 117 .
   Google Scholar
• Cuero , R. G. , Smith , J. E. and Lacey , J. 1987 . Stimulation by Hypopichia butonii and Bacillus amyloliquefaciens of aflatoxin production by Aspergillus flavus in irradiated maize and rice grains . Appl. Environ. Microbiol. , 53 : 1142 – 1146 .
   PubMed Web of Science ®Google Scholar
• Davidson , J. R. , Whitaker , T. B. and Dickens , J. W. 1982 . “ Grading, cleaning, storage, shelling and marketing of peanuts in the United States ” . In American Peanut Research and Education Society , Edited by: Pattee , H. E. , Young , C. T. and Yoakum , T. X. 571 – 623 . New York : John Wiley .
   Google Scholar
• De Koe , W. J. 1999 . Regulations of the European Union for mycotoxins in foods . Arh. Hig. Rada. Toksikol. , 50 : 37 – 46 .
   PubMedGoogle Scholar
• Diener , U. L. and Davis , N. D. 1967 . Limiting temperature and relative humidity for growth and production of aflatoxins and free fatty acids by Aspergillus flavus in sterile peanuts . J. Am. Oil Chem. , 44 : 259 – 263 .
   PubMed Web of Science ®Google Scholar
• Dobson , D. W. and Sweeney , M. J. 1998 . Mycotoxin production by Aspergillus, Fusarium and Penicillium species . Int. J. Food Microbiol. , 43 : 141 – 158 .
   PubMed Web of Science ®Google Scholar
• Donner , M. , Atehnkeng , J. , Sikora , R. A. , Bandyopadhyay , R. and Cotty , P. J. 2009 . Distribution of Aspergillus section Flavi in soils of maize fields in three agroecological zones of Nigeria . Soil Biol. Biochem. , 41 : 37 – 44 .
   Web of Science ®Google Scholar
• Dorner , J. W. and Cole , R. J. 2002 . Effect of application of nontoxigenic strain of Aspergillus flavus and A. parasiticus on subsequent aflatoxin contamination of peanuts in storage . J. Stored Prod. Res. , 38 : 329 – 339 .
   Web of Science ®Google Scholar
• Dorner , J. W. , Cole , R. J. and Blankenship , P. D. 1998 . Effect of inoculum rate of biological control agents on preharvest aflatoxin contamination of peanuts . Biol. Contr. , 12 : 171 – 176 .
   Web of Science ®Google Scholar
• Dowd , P. F. 2003 . Insect management to facilitate preharvest mycotoxin management . J Toxicol. Toxin Rev. , 22 : 327 – 350 .
   Web of Science ®Google Scholar
• Doyle , A. 1998 . Fusarium mycotoxins , USA : Food Research Institute Briefings. University of Wisconsin-Madison . Available at: http://mycoherbicide.net. Accessed April 22, 2010
   Google Scholar
• EC (European Commission) . 2006 . The commission decision, 2006/504/EC . Off. J. Eur. Union. , L199 : 21 – 32 .
   Google Scholar
• EC (European Commision) . 2002b . Commission directive 2002/27/EC of 13 March 2002 amending directive 98/53/EC laying down the sampling methods and the methods of analysis for the official control of the levels for certain contaminants in foodstuffs . Off. J. Eur. Comm. , L 75 : 44 – 45 .
   Google Scholar
• EFSA (European Food Safety Authority) . 2004 . Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to aflatoxin B1 as undesirable substance in animal feed (question No. EFSA-Q-2003-035). Adopted on 3 February 2004 . EFSA J. , 39 : 1 – 27 .
   Google Scholar
• EFSA (European Food Safety Authority) . 2006 . Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to ochratoxin A in food (Question No EFSA-Q-2005-154) adopted on 04 April 2006 . EFSA J. , 365 : 1 – 56 .
   Google Scholar
• EFSA (European Food Safety Authority) . 2007 . Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to the potential increase of consumer health risk by a possible increase of the existing maximum levels for aflatoxins in almonds, hazelsnuts and pistachios and derived products . The EFSA J. , 446 : 1 – 127 .
   Google Scholar
• Ehrlich , K. C. , Chang , P. K. , Yu , J. and Cotty , P. J. 2004 . Aflatoxins biosynthesis cluster gene cypA is requiered for G aflatoxin formation . Appl. Environ. Microbiol. , 70 : 6518 – 6524 .
   PubMed Web of Science ®Google Scholar
• Ehrlich , K. C. , Yu , J. and Cotty , P. J. 2005 . Aflatoxin biosynthesis gene cluster and flanking regions . J. Appl. Microbiol. , 99 : 518 – 527 .
   PubMed Web of Science ®Google Scholar
• El-Nezami , H. S. , Nicoletti , G. , Neal , G. E. , Donohue , D. C. and Ahokas , J. T. 1995 . Aflatoxin M1 in human breast milk samples from Victoria, Australia and Thailand . Food Chem. Toxicol. , 33 : 173 – 179 .
   PubMed Web of Science ®Google Scholar
• Etzel , R. 2002 . Mycotoxins . J. Am. Med. Ass. , 287 : 425 – 427 .
   Web of Science ®Google Scholar
• Fandohan , P. , Gnonlonfin , B. , Hell , K. , Marasas , W. F. O. and Wingfield , M. J. 2005a . Natural occurrence of Fusarium and subsequent fumonisin contamination in preharvest and stored maize in Benin, West Africa . Int. J. Food Microbiol. , 99 : 173 – 183 .
   PubMed Web of Science ®Google Scholar
• Fandohan , P. , Hell , K. , Marasas , W. F. O. and Windfield , M. J. 2003 . Infection of maize by Fusarium species and contamination with fumonisin in Africa . Afr. J. Biotechnol. , 2 : 570 – 579 .
   Google Scholar
• Fandohan , P. , Zoumenou , D. , Hounhouigan , D. J. , Marasas , W. F. O. , Wingfield , M. J. and Hell , K. 2005b . Fate of aflatoxins and fumonisin during the processing of maize into food products in Benin . Int. J. Food Microbiol. , 98 : 249 – 259 .
   PubMed Web of Science ®Google Scholar
• FAO . 1996 . Food and Agricultural Organization. Worldwide regulations for mycotoxins, 1995 , Rome : FAO Food Nutr. Paper. 55. FAO, UN .
   Google Scholar
• FAO . 1997 . Joint FAO/WHO Expert Committee on Food Additives, June 17–26 Rome
   Google Scholar
• FAO . 2000 . Drought in Kenya: Food situation in deteriorating rapidly-first starvation-related deaths Press release 00/40. Available at: http://www.fao.org/WAICENT/IS/PRESS_NE/PRESSENG/2000/pren0040.htm. Accessed April 22, 2010
   Google Scholar
• FAO . 2001/2003 . Manual on the application of the HACCP system in mycotoxin prevention and control FAO . Food Nutr. Paper , 73 : 1 – 124 . Available at: http://www.fao.org/docrep/005/y1390e/y1390e00.HTM. Accessed April 22, 2010.
   Google Scholar
• FAO . 2004 . Worldwide regulations for mycotoxins in food and feed in 2003 FAO . Food Nutr. Paper , : 81 Available at: http://www.fao.org/docrep/007/y5499e/y5499e00.htm. Accessed April 22, 2010
   Google Scholar
• FDA . 2002 . Investigative Operations Manual , Washington, DC , , USA : Food and Drug Administration . Available at: www.fda.gov/ora/inspect_ref/iom/Contents/ch4_TOC.html. Accessed April 24, 2010
   Google Scholar
• FDA . 2004 . Compliance guidance manual Available at: http://www.cfsan.fda.gov. Accessed April 24, 2010
   Google Scholar
• Fellinger , A. 2006 . Worldwide mycotoxin regulations and analytical challenges , 17 – 20 . San Francisco, CA , , USA : World Grain Summit: Foods and Beverages .
   Google Scholar
• Galvanao , F. , Piva , A. , Ritieni , A. and Galvano , G. 2001 . Dietary strategies to counteract the effects of mycotoxins: A review . J. Food Protect. , 64 : 120 – 131 .
   PubMed Web of Science ®Google Scholar
• Gilbert , J. 1988 . Application of mycotoxins RM's in methods development and quality assurance . Fresenius Zeitschrift fur Analy. Chem. , 332 : 602 – 605 .
   Web of Science ®Google Scholar
• Gnonlonfin , G. J. B. , Hell , K. , Fandohan , P. and Siame , A. B. 2008a . Mycoflora and occurrence of aflatoxins and fumonisin B1 in cassava and yam chips from Benin, West Africa . Int. J. Food Microbiol. , 122 : 140 – 147 .
   PubMed Web of Science ®Google Scholar
• Gnonlonfin , G. J. B. , Hell , K. , Siame , A. B. and Fandohan , P. 2008b . Infestation and population dynamics of insects on stored cassava and yam chips in Benin, West Africa . J. Econ. Entomol. , 101 : 1967 – 1973 .
   PubMed Web of Science ®Google Scholar
• Gnonlonfin , G. J. B. , Katerere , D. R. , Adjovi , Y. , Brimer , L. , Shephard , G. S. and Sanni , A. 2010 . Determination of aflatoxin in processed dried cassava root: validation of new analytical method for cassava flour . J. AOAC Int. , 93 ( 6 ) : 1882 – 1887 .
   PubMed Web of Science ®Google Scholar
• Goda , Y. , Akiyama , H. , Otsuki , T. , Fujil , A. and Toyoda , M. 2001 . Application and improvement of aflatoxin analysis in foods using a multifunctional column and HPLC . J. Food Hyg. Soc. Jpn. , 42 : 56 – 62 .
   PubMed Web of Science ®Google Scholar
• Gökmen , V. , Acar , J. and Sarioðlu , K. 2005 . Liquid chromatographic method for the determination of patulin in apple juice using solid-phase extraction . Anal. Chim. Acta , 543 : 64 – 69 .
   Web of Science ®Google Scholar
• Gong , Y. Y. , Hounsa , A. , Egal , S. , Suteliffe , A. E. , Hall , A. J. , Cardwell , K. F. and Wild , C. P. 2004 . Postweaning exposure to aflatoxin results in impaired child growth: A longitudinal study in Benin, West Africa . Environ. Health Pers. , 112 : 1334 – 1338 .
   PubMed Web of Science ®Google Scholar
• Gong , Y. Y. , Egal , S. , Hounsa , S. , Hall , A. J. , Cardwell , K. F. and Wild , C. P. 2003 . Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: The critical role of weaning . Int. J. Epidemiol. , 32 : 556 – 662 .
   PubMed Web of Science ®Google Scholar
• Gong , Y. Y. , Cardwell , K. F. , Hounsa , A. , Eggal , S. , Turner , P. C. , Hall , A. J. and Wild , C. P. 2002 . Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: A cross-sectional study . Brit. Med. J. , 325 20.21
   PubMed Web of Science ®Google Scholar
• Gqaleni , N. , Smith , J. E. , Lacey , J. and Gettinby , G. 1997 . Effects of temperature, water activity and incubation time on production of aflatoxins and cyclopiazonic acid by an isolate of Aspergillus flavus in surface agar culture . Appl. Environ. Microbiol. , 63 : 1048 – 1053 .
   PubMed Web of Science ®Google Scholar
• Groopman , D. J. and Kensler , T. W. 1999 . The light at the end of the tunnel for chemical-specific biomarkers: Daylight or headlight? . Carcinogenesis , 20 : 1 – 11 .
   PubMed Web of Science ®Google Scholar
• Hamiton , D. 2000 . Toxic fungus threatens health of consumers Available at: www.agnic.org/pmp/2000/ama0826.htm. Accessed April 22, 2010
   Google Scholar
• Harvey , R. B. , Huff , W. E. , Kubena , L. F. , Corrier , D. E. and Phillips , T. D. 1988 . Progression of aflatoxicosis in growing barrows . Am. J. Vet. Res. , 49 : 482 – 487 .
   PubMed Web of Science ®Google Scholar
• Hayes , J. D. , Pulford , D. J. , Ellis , E. M. , McLeod , R. , James , R. F. L. , Seidegard , J. , Masialou , E. , Jernstrom , B. and Neal , G. E. 1998 . Regulation of rat glutathione-S-transferase A5 by cancer chemopreventive agents: Mechanisms of inducible resistance to aflatoxin B1 . Chemo-Biol. Inter. , 111/112 : 51 – 67 .
   Web of Science ®Google Scholar
• Heathcote , J. G. and Hibbert , J. R. 1978 . Aflatoxins: Chemical and Biological Aspects , 168 – 173 . New York , , USA : Elsevier .
   Google Scholar
• Hell , K. , Cardwell , F. K. and Poehling , H. M. 2003 . Relationship between management practices, fungal infection and aflatoxin for stored maize in Benin . J. Phytopathol. , 151 : 690 – 698 .
   Web of Science ®Google Scholar
• Hell , K. , Cardwell , K. F. , Setamou , M. and Poehling , H. M. 2000a . The influence of storage practices on aflatoxin contamination in maize in four agroecological zones of Benin, West Africa . J. Stored Prod. Res. , 36 : 365 – 382 .
   PubMed Web of Science ®Google Scholar
• Hell , K. , Cardwell , K. F. , Setamou , M. and Schulthess , F. 2000b . Influence of insect infestation on aflatoxin contamination of stored maize in four agroecological regions in Benin . Afr. Entomol. , 8 : 169 – 177 .
   Web of Science ®Google Scholar
• Hell , K. , Gnonlonfin , G. J. B. , Kodjogbe , G. , Lamboni , Y. and Abdourhamane , I. K. 2009 . Mycoflora and occurrence of aflatoxin in dried vegetables in Benin, Mali and Togo, West Africa . Int. J. Food Microbiol. , 135 : 99 – 104 .
   PubMed Web of Science ®Google Scholar
• Hendrickse , R. G. 1984 . The influence of aflatoxins on child health in the tropics with particular reference to kwashiorkor . Trans. R. Soc. Trop. Med. Hyg. , 78 : 435
   Web of Science ®Google Scholar
• Hennigen , M. R. , ValenteSoares , L. M. , Sanchez , S. , Di Benedetto , N. M. , Longhi , A. , Eyhérabide , G. , Torroba , J. and Zanelli , M. 2000 . “ Fumonisin in corn hybrids grown in Argentina for two consecutive seasons ” . In Proceeding of the Xth International IUPAC Symposium on Mycotoxins and Phycotoxins. 21–25, May 2000 , Edited by: De Koe , W. J. , Samson , R. A. , van Egmond , H. P. , Gilbert , J. and Sabino , M. 331 – 339 . Brazil : Guaruja .
   Google Scholar
• Henry , S. , Bosch , F. X. , Troxell , T. C. and Bolber , P. M. 1999 . Reducing liver cancer-global control of aflatoxin . Sci. , 286 : 2453 – 2454 .
   PubMed Web of Science ®Google Scholar
• Hill , R. A. , Blankenship , P. D. , Cole , R. J. and Sanders , T. H. 1983 . Effects of soil moisture and temperature on preharvest invasion of peanuts by the Aspergillus flavus group and subsequent aflatoxin development . Appl. Environ. Microbiol. , 45 : 628 – 633 .
   PubMed Web of Science ®Google Scholar
• Holmes , R. A. , Boston , R. S. and Payne , G. A. 2008 . Diverse inhibitors of aflatoxin biosynthesis . Appl. Microbiol. Biotechnol. , 78 : 559 – 572 .
   PubMed Web of Science ®Google Scholar
• Houssou , P. , Ahohuendo , B. C. , Fandohan , P. , Kpodo , K. , Hounhouigan , D. J. and Jakobsen , M. 2009 . Natural infection of cowpea (Vigna unguiculata (L.) Walp.) by toxigenic fungi and mycotoxin contamination in Benin, West Africa . J. Stored Prod. Res. , 45 : 40 – 45 .
   Web of Science ®Google Scholar
• IARC . 1993 . “ Some naturally occurring substances: Food items and constituents, heterocyclic amines and mycotoxins. IARC monographs on evaluation of carciogenic risk to humans ” . Lyon , , France : International Agency for Research on Cancer 56 .
   Google Scholar
• Ito , Y. , Peterson , S. W. , Wicklow , D. T. and Goto , T. 2001 . Aspergillus pseudotamarii a new aflatoxin producing species in Aspergillus section Flavi . Mycol. Res. , 105 : 233 – 239 .
   Web of Science ®Google Scholar
• James , B. , Adda , C. , Cardwell , K. , Annang , D. , Hell , K. , Korie , S. , Edorh , M. , Gbeassor , F. , Nagatey , K. and Houenou , G. 2007 . Public information campaign on aflatoxin contamination of maize grains in market stores in Benin, Ghana and Togo . Food Addit. Contam. , 24 : 1283 – 1291 .
   PubMed Web of Science ®Google Scholar
• Jaimes , J. , Fente , C. A. , Vasquez , B. I. , Franco , C. M. , Cepeda , C. , Mahuzier , G. and Prognon , P. 2000 . Application of the assay of aflatoxins by liquid chromatography with fluorescence detection in food analysis . J. Chromatogr. A , 882 : 1 – 10 .
   PubMed Web of Science ®Google Scholar
• Jaime-Garcia , R. and Cotty , P. J. 2004 . Spacial relationships of soil texture and crop rotation to Aspergillus flavus community structure in South Texas . Phytopathology. , 96 : 599 – 607 .
   Web of Science ®Google Scholar
• JECFA . 2000 . “ Joint FAO/WHO Expert Committee on Food Additives, 53rd Report ” . Safety .
   Google Scholar
• Jiang , Y. , Jolly , P. E. , Ellis , W. O. , Wang , J. S. , Phillips , T. D. and Williams , J. H. 2005 . Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians . Int. Immunol. , 17 : 807 – 814 .
   PubMed Web of Science ®Google Scholar
• Jolly , P. , Jiang , Y. , Ellis , W. , Awuah , R. , Nnedu , O. , Phillips , T. , Wang , J. S. , Afriye-Gyawu , E. , Tang , L. , Person , S. , Williams , J. and Jolly , C. 2006 . Determinants of aflatoxin levels in Ghanaians: Sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices . Int. J. Hyg. Environ. Health , 209 : 345 – 358 .
   PubMed Web of Science ®Google Scholar
• Jones , F T. , Genter , M. B. , Hagler , W. M. , Hansen , J. A. , Mowrey , B. A. , Poore , M. H. and Whitlow , L. W. 1994 . Understanding and coping with effects of mycotoxins in livestock feed and forage , 1 – 14 . North Carolina Cooperative Extension Sercive .
   Google Scholar
• Kaaya , A. N. , Kyamuhangire , W. and Kyamanywa , S. 2006 . Factors affecting aflatoxin contamination of harvested maize in the three agroecological zones of Uganda . J. Appl. Sci. , 6 : 2401 – 2407 .
   Google Scholar
• Kabak , B. , Dobson , A. D. W. and Var , I. 2006 . Strategies to prevent mycotoxin contamination of food and animal feed: A review . Crit. Rev. Food Sci. Nutr. , 46 : 593 – 619 .
   PubMed Web of Science ®Google Scholar
• Kankolongo , M. , Hell , K. and Nawa , I. N. 2009 . Assessment for fungal, mycotoxin and insects spoilage in maize stored for human consumption in Zambia . J. Sci. Food Agric. , 89 : 1366 – 1375 .
   Web of Science ®Google Scholar
• Kensler , T. W. , Egner , P. A. , Wang , J. B. , Zhu , Y. R. , Zhang , B. C. , Lu , P. X. , Chen , J. G. , Qian , G. S. , Kuang , S. Y. , Jackson , P. E. , Gange , S. J. , Jacobson , L. P. , Munoz , A. and Groopman , J. D. 2004 . Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas . Gastroenterol. , 127 : 310 – 318 .
   PubMed Web of Science ®Google Scholar
• Kim , E. K. , Shon , D. H. , Ryu , D. , Park , J. W. , Hwang , H. J. and Kim , Y. B. 2000 . Occurrence of aflatoxin M1 in Korean dairy products determined by ELISA and HPLC . Food Addit. Contam. , 17 : 59 – 64 .
   PubMed Web of Science ®Google Scholar
• Kirk , G. D. , Bah , E. and Montesano , R. 2006 . Molecular epidemiology of human liver cancer: Insights into etiology, pathogenesis and prevention from The Gambia, West Africa . Carcinogenesis , 27 : 2070 – 2082 .
   PubMed Web of Science ®Google Scholar
• Kirk , G. D. , Lesi , O. A. , Mendy , M. , Akano , A. O. , Sam , O. , Goedert , J. J. , Hainaut , P. , Hall , A. J. , Whittle , H. and Montesano , R. 2004 . The Gambia Liver Cancer Study: Infection with hepatitis B and C and the risk of hepatocellular carcinoma in West Africa . Hepatol. , 39 : 211 – 219 .
   PubMed Web of Science ®Google Scholar
• Kpodo , K. , Sorensen , A. K. and Jakobsen , M. 1996 . The occurrence of mycotoxins in fermented maize products . Food Chem. , 56 : 147 – 153 .
   Web of Science ®Google Scholar
• Kpodo , K. , Thrane , U. and Hald , B. 2000 . Fusaria and fumonisins in maize from Ghana and their co-occurrence with aflatoxins . Int. J. Food Microbiol. , 61 : 147 – 157 .
   PubMed Web of Science ®Google Scholar
• Kubena , L. F. , Harvey , R. B. , Huff , W. E. , Corrier , D. E. , Phillips , T. D. and Rottinghaus , G. E. 1990 . Efficacy of a hydrated sodium calcium aluminosilicate to reduce the toxicity of aflatoxin and T-2 toxin . Poultry Sci. , 69 : 1078 – 1086 .
   PubMed Web of Science ®Google Scholar
• Kurtzman , C. P. , Horn , B. W. and Hesseltine , C. W. 1987 . Aspergillus nomius, a new aflatoxin producing species related to Aspergillus flavus and Aspergillus tamarii . Antoine van Leeuwenhoek , 53 : 147 – 158 .
   PubMed Web of Science ®Google Scholar
• Lacey , J. and Magan , N. 1991 . “ Fungi colonising cereal grain: Their occurrence and water and temperature relationships ” . In Cereal Grain-Mycotoxins, Fungi and Quality in Storage. Chapter 5, , Edited by: Chelkowski , J. 77 – 118 . Amterdam : Elsevier .
   Google Scholar
• Lanyasunya , T. P. , Wamae , L. W. , Musa , H. H. , Olowofeso , O. and Lokwaleput , I. K. 2005 . The risk of mycotoxins contamination of dairy feed and milk on smallholder dairy farms in Kenya . Pakistan J. Nutr. , 4 : 162 – 169 .
   Google Scholar
• Lawrence , J. F. , Menard , C. , Yeung , J. and Benrejeb , S. 2000 . Evaluation of silica-and sepharose based immunoaffinity sorbents for sample cleanup in determination of fumonisin B1 and B2 in corn products . J. AOAC Int. , 83 : 597 – 603 .
   PubMed Web of Science ®Google Scholar
• Lewis , L. , Onsongo , M. , Njapau , H. , Schurz-Rogers , H. , Luber , G. , Kieszak , S. , Nyamongo , J. , Backer , L. , Dahiye , A. M. , Misore , A. , Decoct , K. and Rubin , C. 2005 . Aflatoxin contamination of commercial maize products during an outbreak of acute aflatoxicosis in Eastern and Central Kenya . Environ. Health Pers. , 113 : 1763 – 1767 .
   PubMed Web of Science ®Google Scholar
• Lussenhop , J. L. and Wicklow , D. T. 1991 . Nitidulid beetles as a source of Aspergillus flavus infective inoculum . Trans. Jap. Mycol. Soc. , 31 : 63 – 74 .
   Google Scholar
• Lynch , R. E. , Dicko , I. O. , Some , S. A. and Quadraogo , A. P. 1991 . Effect of harvest date on termite damage, yield and aflatoxin contamination in groundnut in Burkina Faso. Int. Arac . Newsletter , 10 : 24 – 25 .
   Google Scholar
• Lynch , R. E. and Wilson , D. M. 1991 . Enhanced infection of peanut, Arachis hypogaea L., seeds with Aspergillus flavus group fungi due to external scarification of peanut pods by the lesser cornstalk borer, Elasmopalpus lignosselus (Zeller) . Peanut Sci. , 18 : 110 – 116 .
   Google Scholar
• Magan , N. , Hope , R. , Cairns , V. and Aldred , D. 2003 . Post-harvest fungal ecology: Impact of fungal growth and mycotoxin accumulation in stored grain . Eur. J. Plant Pathol. , 109 : 723 – 730 .
   Web of Science ®Google Scholar
• Magan , N. and Aldred , D. 2007 . Post-harvest control strategies: Minimizing mycotoxins in the food chain . Int. J. Food Microbiol. , 119 : 131 – 139 .
   PubMed Web of Science ®Google Scholar
• Manjula , K. , Hell , K. , Fandohan , P. , Abass , A. and Bandyopadhyay , R. 2009 . Aflatoxin and fumonisin contamination of cassava products and maize grain from markets in Tanzania and republic of the Congo . Toxin Rev. , 28 : 63 – 69 .
   Web of Science ®Google Scholar
• Marasas , W. F. O. 1996 . “ Fumonisins: History, worldwide occurrence and impact ” . In Fumonisins in Food , Edited by: Jackson , L. S. , Devries , J. W. and Bullerman , L. B. 1 – 17 . New York : Plenum Press .
   Google Scholar
• Marasas , W. F. O. 2001 . Discovery and occurrence of the fumonisins: A historical perspective . Environ. Health Pers. , 109 : 239 – 243 .
   PubMed Web of Science ®Google Scholar
• Marin , S. , Sanchis , V. , Rull , F. , Ramos , A. J. and Magan , N. 1998 . Colonisation of maize by Fusarium moniliforme and Fusarium proliferatum in the presence of competing fungi and their impact on fumonisin production . J. Food Protec. , 61 : 1489 – 1496 .
   PubMed Web of Science ®Google Scholar
• Meky , F. A. , Hardie , L. J. , Evans , S. W. and Wild , C. P. 2001 . Deoxynivalenol-induced immunomodulation of human lymphocyte proliferation and cytokine production . Food Chem. Toxicol. , 39 : 827 – 836 .
   PubMed Web of Science ®Google Scholar
• McLean , M. 1995 . The phytotoxicity of selected mycotoxins on mature, germinating Zea mays embryos . Mycopathologia , 132 : 173 – 183 .
   PubMed Web of Science ®Google Scholar
• McMillian , W. W. , Widstrom , N. M. , Wilson , D. M. and Evans , B. D. 1990 . Annual contamination of Heliothis zea (Lepidoptera: Noctuidae) moths with Aspergillus flavus and incidence of aflatoxin contamination in preharvest corn in the Georgia coastal plain . J. Entomol. Sci. , 25 : 123 – 124 .
   Web of Science ®Google Scholar
• Mestres , C. , Bassa , S. , Fagbohoun , E. , Nogo , M. , Hell , K. , Vernier , P. , Champiat , D. , Hounhouigan , J. and Cardwell , K. F. 2004 . Yam chip food sub-sector: Hazardous practices and presence of aflatoxins in Benin . J. Stored Prod. Res. , 40 : 575 – 585 .
   Web of Science ®Google Scholar
• Miller , J. D. 1995 . Fungi and mycotoxins in grain: Implications for stored product research . J. Stored Prod. Res. , 31 : 1 – 16 .
   Web of Science ®Google Scholar
• Mills , J. T. 1983 . Insect-fungus associations influencing seed deterioration . Phytopathol. , 73 : 330 – 335 .
   Web of Science ®Google Scholar
• Miraglia , M. , De Santis , B. , Minardi , V. , Debegnach , F. and Brera , C. 2005 . The role of sampling in mycotoxin contamination: An holistic view . Food Addit. Contam.: Part A , 22 : 31 – 36 .
   PubMed Web of Science ®Google Scholar
• Molina , M. and Giannuzzi , L. 2002 . Modelling of aflatoxin production by Aspergillus parasiticus in a solid medium at different temperatures, pH and propionic acid concentrations . Food Res. Int. , 35 : 585 – 594 .
   Web of Science ®Google Scholar
• Montesano , R. , Hainaut , P. and Wild , C. P. 1997 . Hepatocellular carcinoma: From gene to public health . J. Natl. Cancer Inst. , 89 : 1844 – 1851 .
   PubMed Web of Science ®Google Scholar
• Mora , M. and Lacey , J. 1997 . Handling and aflatoxin contamination of white maize in Costa Rica . Mycopathologia , 138 : 77 – 89 .
   PubMed Web of Science ®Google Scholar
• Mphande , F. A. , Siame , A. B. and Taylor , J. E. 2004 . Fungi, aflatoxins and cyclopiazonic acid associated with peanut retailing in Botswana . J. Food Prot. , 67 : 96 – 102 .
   PubMed Web of Science ®Google Scholar
• Mulé , G. , Gonzalez-jaén , M. T. , Hornok , L. , Nicholson , P. and Waalwijk , C. 2005 . Advances in molecular diagnosis of toxigenic Fusarium species . Food Add. Cont. , 22 : 16 – 323 .
   Google Scholar
• Munkvold , G. P. 2003 . Cultural and genetic approaches to managing mycotoxins in maize . Ann. Rev. Phytopathol. , 41 : 99 – 116 .
   PubMed Web of Science ®Google Scholar
• Munkvold , G. P. and Desjardins , A. E. 1997 . Fumonisins in maize. Can we reduce their occurrence? . Plant Dis. , 81 : 556 – 564 .
   PubMed Web of Science ®Google Scholar
• Munkvold , G. P. and Hellminch , R. L. 2000 . Genetically modified, insect resistant maize, implications for management of ear and stalk disease , Plant Health Program . Available at: http://www.planthealthprogress.org/current/reviews/maize/article.html. Accessed April 24, 2010
   Google Scholar
• Mutegi , C. K. , Ngugi , H. K. , Hendriks , S. L. and Jones , R. B. 2009 . Prevalence and factors associated with aflatoxin contamination of peanuts from Western Kenya . Int. J. Food Microbiol. , 13 : 27 – 34 .
   Google Scholar
• Mutungi , C. , Lamuka , P. , Arimi , S. , Gathumbi , J. and Onyango , C. 2008 . The fate of aflatoxins during processing of maize into muthokoi–A traditional Kenyan food . Food Contr. , 19 : 714 – 721 .
   Web of Science ®Google Scholar
• Muzanila , Y. C. , Brennan , J. G. and King , R. D. 2000 . Residual cyanogens, chemical composition and aflatoxins in cassava flour from Tanzanian villages . Food Chem. , 70 : 45 – 49 .
   Web of Science ®Google Scholar
• Mwihia , J. T. , Straetmans , M. , Ibrahim , A. , Njau , J. , Muhenje , O. , Guracha , A. , Gikundi , S. , Mutonga , D. , Tetteh , C. , Likimani , S. , Breiman , R. F. , Njenga , K. and Lewis , L. 2008 . Aflatoxin Levels in Locally Grown Maize from Makueni District, Kenya . East Afr. Med. J. , 85 ( 7 ) : 311 – 317 .
   PubMedGoogle Scholar
• Ni , X. and Streett , D. A. 2005 . Modulation of water activity on fungicide effect on Aspergillus niger growth in Sabouraud dextrose agar medium . Lett. Appl. Microbiol. , 41 : 428 – 433 .
   PubMed Web of Science ®Google Scholar
• Northolt , M. D. , van Egmond , H. P. and Paulsch , W. E. 1977 . Differences in Aspergillus flavus strains in growth and aflatoxin B1 production in relation to water activity and temperature . J. Food Prot. , 40 : 778 – 781 .
   PubMed Web of Science ®Google Scholar
• Odindo , M. O. , Otieno , W. A. , Oloo , G. W. , Kilori , J. and Odhiambo , R. C. 1989 . Prevalence of microorganisms in field-sampled borers in sorghum, maize and cowpea in western Kenya . Insect Sci. Appl. , 10 : 225 – 228 .
   Google Scholar
• Ominski , K. H. , Marquardt , R. R. , Sinha , R. N. and Abramson , D. 1994 . “ Ecological aspects of growth and mycotoxin production by storage fungi ” . In Mycotoxins in Grains. Compounds Other than Aflatoxin , Edited by: Miller , J. D. and Trenholm , H. L. 287 – 305 . USA : Eagen Press .
   Google Scholar
• Patten , R. C. 1981 . Aflatoxins and disease . Am. J. Trop. Med. Hyg. , 30 : 422 – 425 .
   PubMed Web of Science ®Google Scholar
• Pestka , J. J. , Zhou , Hui-Ren , Moon , Y. and Chung , Y. J. 2004 . Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: Unraveling a paradox . Toxicol. Lett. , 153 : 61 – 73 .
   PubMed Web of Science ®Google Scholar
• Peterson , S. W. , Ito , Y. , Horn , B. W. and Goto , T. 2001 . Aspergillus bombycis, a new aflatoxigenic species, A. Nomius . Mycologia , 93 : 689 – 703 .
   Web of Science ®Google Scholar
• Pietri , A. , Bertuzzi , T. , Moschini , M. and Piva , G. 2003 . Aflatoxin M1 occurrence in milk samples destined for parmigiano reggiano cheese production . Ital. J. Food Sci. , 15 : 1 – 6 .
   Google Scholar
• Pitt , J. I. 2000 . Toxigenic fungi: Which are important? . Med. Mycol. , 38 : 17 – 22 .
   PubMed Web of Science ®Google Scholar
• Pitt , J. I. and Hocking , A. D. 1999 . Fungi and Food Spoilage , 593 Gaithersburg , , Maryland : Chapman and Hall . Second edition
   Google Scholar
• Pitt , R. E. 1993 . A descriptive model of mold growth and aflatoxin formation as affected by environmental conditions . J. Food Protec. , 56 : 139 – 146 .
   PubMed Web of Science ®Google Scholar
• Pittet , A. 1998 . Natural occurrence of mycotoxins in foods and feeds-an updated review . Rev. Med. Vet. , 149 : 479 – 492 .
   Google Scholar
• Phillips , T. D. , Afriyie-Gyawu , E. , Williams , J. , Huebner , H. , Ankrah , N. -A. , Ofori-Adjei , D. , Jolly , P. , Johnson , N. , Taylor , J. , Marroquin-Cardona , A. , Xu , L. , Tang , L. and Wang , J. S. 2007 . Reducing human exposure to aflatoxin through the use of clay: A review . Food Add. Cont. , 25 : 134 – 145 .
   Google Scholar
• Probst , C. , Shulthess , F. and Cotty , P. J. 2010 . Impact of Aspergillus section Flavi community structure on the development of lethal levels of aflatoxins in Kenyan maize (Zea mays) . J. Appl. Microbiol. , 108 : 600 – 610 .
   PubMed Web of Science ®Google Scholar
• Probst , C. , Njapau , H. and Cotty , P. J. 2007 . Outbreak of an acute aflatoxicosis in Kenya in 2004: Identification of the causal agent . Appl. Environ. Microbiol. , 73 : 2762 – 2764 .
   PubMed Web of Science ®Google Scholar
• Rachaputi , N. R. , Wright , G. C. and Kroschi , S. 2002 . Management practices to minimize pre-harvest aflatoxin contamination in Australian groundnuts . Aus. J. Exp. Agric. , 42 : 595 – 605 .
   Google Scholar
• Rahimi , E. , Bonyadian , M. , Rafei , M. and Kazemeini , H. R. 2010 . Occurrence of aflatoxin M1 in raw milk of five dairy species in Ahvaz, Iran . Food Chem. Toxicol. , 48 : 129 – 131 .
   PubMed Web of Science ®Google Scholar
• Ramjee , G. 1996 . “ Aflatoxin, kwashiorkor and morbidity ” . In Proceedings of the Workshop on Mycotoxins in Food in Africa. November 6–10, 1995 at Cotonou, Benin , Edited by: Cardwell , K. F. 25 Benin : International Institute of Tropical Agricultuure .
   Google Scholar
• Saito , M. and Tsuruta , O. 1993 . A new variety of Aspergillus flavus from tropical soil in Thailand and its aflatoxin productivity . Proc. Japanese Associ. Mycotoxicol. , 37 : 31 – 36 .
   Google Scholar
• Salifu , A. 1981 . Mycotoxins in short season sorghum in northern Nigeria . Samaru J. Agric. Res. , 1 : 83 – 88 .
   Google Scholar
• Samapundo , S. , Devlieghere , F. , Geeraerd , A. H. , De Meulenaer , B. , Van Impe , J. F. and Debevere , J. 2007 . Modelling of the individual and combined effects of water activity and temperature on the radial growth of Aspergillus flavus and A. parasiticus on corn . Food Microbiol. , 24 : 517 – 529 .
   PubMed Web of Science ®Google Scholar
• Saquib , M. 2000 . “ A study of the impact of environmental requirements in India's export performance and the scoping study for environmentally friendly products, FAO, Mycotoxin prevention and control in foodgrains-aflatoxin research on grain in Asia, UNCTAD ” . Available at: http://www.fao.org/docrep/x0036e/x0036e1e.htm. Accessed April 24, 2010
   Google Scholar
• Seenappa , M. , Keswani , C. L. and Kundya , T. M. 1983 . Aspergillus infection and aflatoxin production in some cowpea (Vigna unguiculata (L.) Walp) lines in Tanzania . Mycopathologia , 83 : 103 – 106 .
   PubMed Web of Science ®Google Scholar
• Setamou , M. , Cardwell , K. F. , Schulthess , F. and Hell , K. 1997 . Aspergillus flavus infection and aflatoxin contamination of preharvest maize in Benin . Plant Dis. , 81 : 1323 – 1327 .
   PubMed Web of Science ®Google Scholar
• Setamou , M. , Cardwell , K. F. , Schulthess , F. and Hell , K. 1998 . Effect of insect damage to maize ears, with special reference to Mussidia nigrivenella (Lepidoptera: Pyralidae), on Aspergillus flavus (Deutoremycetes: Monoliales). Infection and aflatoxin production in maize before harvest in the Republic of Benin . J. Econ. Entomol. , 91 : 433 – 438 .
   Web of Science ®Google Scholar
• Shephard , G. S. 2008 . Determination of mycotoxins in human foods . Chem. Soc. Rev. , 37 : 2468 – 2477 .
   PubMed Web of Science ®Google Scholar
• Shephard , G. S. , Thiel , P. G. , Stockenstrom , S. and Sydenham , E. W. 1996 . Worldwide survey of fumonisin contamination of corn and corn-based products . J. AOAC Int. , 79 : 671 – 687 .
   PubMed Web of Science ®Google Scholar
• Shetty , P. H. and Bhat , R. V. 1999 . A physical method for segregation of fumonisin-contaminated maize . Food Chem. , 66 : 371 – 374 .
   Web of Science ®Google Scholar
• Sinha , K. K. and Sinha , A. K. 1992 . Impact of stored grain pests on seed deterioration and aflatoxin contamination in maize . J. Stored Prod. Res. , 28 : 211 – 219 .
   Web of Science ®Google Scholar
• Leger , R. J. St. , Screen , S. E. and Shams-Pirzadeh , B. 2000 . Lack of host specialiazation in Aspergillus flavus . Appl. Environ. Microbiol. , 66 : 320 – 324 .
   PubMed Web of Science ®Google Scholar
• Sydenham , E. W. and Shephard , G. S. 1996 . Progress in Food Contaminant Analysis , Edited by: Gilbert , J. 65 – 146 . UK : Blackie Academic & Professional .
   Google Scholar
• Song , D. K. and Karr , A. L. 1993 . Soybean phytoalexin, glyceollin, prevents accumulation of aflatoxin B1 in cultures of Aspergillus flavus . J. Chem. Ecol. , 19 : 1183 – 1194 .
   Web of Science ®Google Scholar
• Trucksess , M. W. 2000 . In Official Methods of Analysis of AOAC International, Seventeeth edition. Chap. 49 , Edited by: Horwitz , W. MA , , USA : AOAC International .
   Google Scholar
• Trucksess , M. W. and Pohland , A. E. 2002 . Methods and method evaluation for mycotoxins . Mol. Biotechnol. , 22 : 287 – 292 .
   PubMed Web of Science ®Google Scholar
• Turner , P. , Sylla , A. , Gong , Y. , Diallo , M. , Sutcliffe , A. , Hall , A. and Wild , C. 2005 . Reduction of exposure to carcinogenic aflatoxins by post harvest intervention measures in West Africa: A community-based intervention study . Lancet , 365 : 1950 – 1959 .
   PubMed Web of Science ®Google Scholar
• Turner , P. C. , Mendy , M. , White , H. , Fortuin , M. , Hall , A. J. and Wild , C. P. 2000 . Hepatitis B infection and aflatoxin biomarker levels in Gambian children . Trop. Med. Int. Health. , 5 : 837 – 841 .
   PubMed Web of Science ®Google Scholar
• Turner , P. C. , Sylla , A. , Diallo , M. S. , Castegnaro , J. J. , Hall , A. J. and Wild , C. P. 2002 . The role of aflatoxins and hepatitis viruses in the etiopathogenesis of hepatocellular carcinoma: A basis for primary prevention in Guinea–Conakry, West Africa . J. Gastroent. Hep. , 17 : 441 – 448 .
   PubMed Web of Science ®Google Scholar
• Turner , P. C. , Moore , S. E. , Hall , A. J. , Prentice , A. M. and Wild , C. P. 2003 . Modification of immune function through exposure to dietary aflatoxin in Gambian children . Environ. Health Pers. , 111 : 217 – 220 .
   PubMed Web of Science ®Google Scholar
• Udoh , J. M. , Cardwell , K. F. and Ikotun , T. 2000 . Storage structures and aflatoxin content of maize in five agro-ecological zones of Nigeria . J. Stored Prod. Res. , 36 : 187 – 201 .
   Web of Science ®Google Scholar
• Uriah , N. , Ibeh , I. N. and Oluwafemi , F. 2001 . A study of the impact of aflatoxin on the human reproduction . Afr. J. Reprod. Health , 5 : 106 – 110 .
   Google Scholar
• Van Egmond , H. P. 2002 . Worlwide regulations for mycooxins . Adv. Exp.Med. Biol. , 504 : 257 – 269 .
   PubMed Web of Science ®Google Scholar
• Van Rensburg , J. C. , van Rensburg , C. E. J. , van Ryssen , J. B. J. , Casey , N. H. and Rottinghaus , G. E. 2006 . In vitro and in vivo assessment of humic acid as an aflatoxin binder in broiler chickens . Poultry Sci. , 85 : 1576 – 1583 .
   PubMed Web of Science ®Google Scholar
• Veldman , A. , Meijs , J. A. C. , Borggreve , G. J. and Heeres-van-der-Tol , J. J. 1992 . Carry-over of aflatoxin from cows’ food to milk . Ann. Prod. , 55 : 163 – 168 .
   Google Scholar
• Velluti , A. , Marin , S. , Bettucci , L. , Ramos , A. J. and Sanchis , V. 2000 . The effect of fungal competition of maize grain by Fusarium moniliforme, F. proliferatum and F. graminearum and on fumonisin B1 and zearalenone formation . Int. J. Food Microbiol. , 59 : 59 – 66 .
   PubMed Web of Science ®Google Scholar
• Viquez , O. M. , Castell-Perez , M. E. , Shelby , R. A. and Brown , G. 1994 . Aflatoxin contamination in corn samples due to environmental conditions, aflatoxin-producing strains, and nutrients in grain grown in Costa Rica . J. Agric. Food Chem. , 42 : 2551 – 2555 .
   Web of Science ®Google Scholar
• Wagacha , J. M. and Muthomi , J. W. 2008 . Mycotoxin problem in Africa: Current status, implications to food safety and health and possible management strategies . Int. J. Food Microbiol. , 124 : 1 – 12 .
   PubMed Web of Science ®Google Scholar
• Wang , J. S. , Luo , H. , Billam , M. , Wang , Z. , Guan , H. , Tang , L. , Golgston , T. , Afriyie-Gyawu , E. , Lovett , C. , Griswold , J. , Brattin , B. , Taylor , R. J. , Huebner , H. J. and Phillips , T. D. 2005 . Short-term safety evaluation of processed calcium montmorillonite clay (Novasil) in human . Food Add. Cont. , 22 : 270 – 279 .
   PubMed Web of Science ®Google Scholar
• Wareing , P. W. , Westby , A. , Gibbs , J. A. , Allotey , L. T. and Halm , M. 2001 . Consumer preferences and fungal and mycotoxin contamination of dried cassava products from Ghana . Int. J. Food Sci. Technol. , 36 : 1 – 10 .
   Web of Science ®Google Scholar
• Whitaker , T. B. 2003 . Standardisation of mycotoxin sampling procedures: An urgent necessity . Food Contr. , 14 : 233 – 237 .
   Web of Science ®Google Scholar
• Wicklow , D. T. 1988 . “ Epidemiology of Aspergillus flavus in corn ” . In Aflatoxin in Corn: New Perspectives , Edited by: Shotwell , O. L. 315 – 323 . Ames, Iowa : North Central Regional Research Publication 329. Iowa State University .
   Google Scholar
• Wild , C. P. 1996 . “ Summury of data on aflatoxin exposure in West Africa ” . In Proceedings of the Workshop on Mycotoxins in Food in Africa. Novemver 6–10 at Cotonou, Benin , Edited by: Cardwell , K. F. 26 Benin : International Institute of Tropical Agriculture .
   Google Scholar
• Williams , J. H. , Grubb , J. A. , Davis , J. W. , Wang , J. , Jolly , P. E. , Ankrah , N. , Ellis , W. O. , Afriyie-Gyawu , E. , Johnson , N. M. , Robinson , A. G. and Phillips , T. D. 2010 . HIV and hepatocellular and esophageal carcinomas related to consumption of mycotoxin-prone foods in sub-Saharan Africa . Am. J. Clin. Nutr. , 92 : 1 – 7 .
   PubMed Web of Science ®Google Scholar
• Williams , J. H. , Phillips , T. D. , Jolly , P. E. , Stiles , J. K. , Jolly , C. M. and Aggarwal , D. 2004 . Human aflatoxicosis in developing countries: A reviews of toxicology, exposure, potential health consequences, and interventions . Am. J. Clin. Nutr. , 80 : 1106 – 1122 .
   PubMed Web of Science ®Google Scholar
• Wilson , D. M. , Mubatanhema , W. and Jurjevic , Z. 2002 . Biology and ecology of mycotoxigenic Aspergillus species as related to economic and health concerns . Adv. Exp. Med. Biol. , 504 : 3 – 17 .
   PubMed Web of Science ®Google Scholar
• Wu , F. 2006 . Mycotoxin reduction in Bt corn: Potential economic, health, and regulatory impact , ISB News Report, September 2006 .
   Google Scholar
• Yu , F. Y. and Chu , F. S. 1999 . Production and characterization of a monoclonal anti-anti-idiotype antibody against fumonisin B1 . J. Agric. Food Chem. , 47 : 4815 – 4820 .
   PubMed Web of Science ®Google Scholar
• Yu , J. , Bhatnager , D. and Ehrlich , K. 2002 . Aflatoxin biosynthesis. Review . Rev. Iberoam Micol. , 19 : 191 – 200 .
   PubMedGoogle Scholar
• Yu , Jae-Hyuk and Keller , N . 2005 . Regulation of secondary metabolism in filamentous fungi . Ann. Rev. Phytopathol. , 43 : 437 – 458 .
   PubMed Web of Science ®Google Scholar
• Zummo , N. and Scott , G. E. 1992 . Interaction of Fusarium moniliforme and Aspergillus flavus on kernel infection and aflatoxin contamination in maize ears . Plant Dis. , 76 : 771 – 773 .
   Web of Science ®Google Scholar