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Original Articles

Black Pepper and Health Claims: A Comprehensive Treatise

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Pages 875-886 | Published online: 14 Jun 2013

REFERENCES

  • Agbor , G. A. , Vinson , J. A. , Oben , J. E. and Ngogang , J. Y. 2006 . Comparative analysis of the in vitro antioxidant activity of white and black pepper . Nutr. Res. , 26 : 659 – 663 .
  • Agbor , A. G. , Vinson , A. J. , Oben , E. J. and Ngogang , Y. J. 2010 . Antioxidant effect of herbs and spices on copper mediated oxidation of lower and very low density lipoprotein . China J. Nat. Med. , 8 : 114 – 120 .
  • Aggarwal , B. B. 2010 . Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals . Annu. Rev. Nutr. , 30 : 173 – 199 .
  • Amakura , Y. , Tsutsumi , T. , Sasaki , K. , Yoshida , T. and Maitani , T. 2003 . Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8 tetrachlorodibenzo-p-dioxin . Biol. Pharm. Bull. , 26 : 1754 – 1760 .
  • Anto , R. J. , Mukhopadyah , A. , Denning , K. and Aggarwal , B. B. 2002 . Curcumin induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release; its suppression by ectopic expression of Bcl-2 and Bcl-xl . Carcinogenesis. , 23 : 143 – 150 .
  • Ao , P. , Hu , S. and Zhao , A. 1998 . Essential oil analysis and trace element study of the roots of Piper Nigrum L . Zhongguo. Zhong. Yao. Za. Zhi. , 23 : 42 – 63 .
  • Arora , D. S. and Kaur , J. 1999 . Antimicrobial activity of spices . Int. J. Antimicrob. Agents. , 12 : 257 – 262 .
  • Badmaev , V. , Majeed , M. and Norkus , E. 1999 . Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation . Nutr. Res. , 193 : 381 – 388 .
  • Badmaev , V. , Majeed , M. and Prakash , L. 2000 . Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation . J. Nutr. Biochem. , 11 : 109 – 113 .
  • Bandhopadhyay , C. , Narayan , V. S. and Variyar , P. S. 1990 . Phenolics of green pepper berries Piper Nigrum L . J. Agric. Food. Chem. , 38 : 1696 – 1699 .
  • Bang , J. S. , Oh da , H. , Choi , H. M. , Sur , B. J. , Lim , S. J. , Kim , J. Y. , Yang , H. I , Yoo , M. C. , Hahm , D. H. and Kim , K. S. 2009 . Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models . Arthritis. Res. Ther. , 11 : R49
  • Bhardwaj , R. K. , Glaeser , H. , Becquemont , L. , Klotz , U. , Gupta , S. K. and Fromm , M. F. 2002 . Piperine, a major constituent of black pepper, inhibits human p-glycoprotein and CYP3A4 . J. Pharmacol. Exp. Ther. , 302 : 645 – 650 .
  • Bhutani , M. K. , Bishnoi , M. and Kulkarni , S. K. 2009 . Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes . Pharmacol. Biochem. Behav. , 92 : 39 – 43 .
  • Bogomolny , E. , Argov , S. , Mordechai , S. and Huleihel , M. 2008 . Monitoring of viral cancer progression using FTIR microscopy: A comparative study of intact cells and tissues . Biochim. Biophys. Acta. , 1780 : 1038 – 1046 .
  • Bonjar , G. H. S. 2004 . Screening for antibacterial properties of some Iranian plants against two strains of Escherichia Coli . Asian J. Plant Sci. , 3 : 310 – 314 .
  • Butt , M. S. and Sultan , M. T. 2010 . Nigella sativa: Reduces the risk of various maladies . Crit. Rev. Food Sci. Nutr. , 50 : 654 – 665 .
  • Butt , M. S. , Sultan , M. T. , Butt , M. S. and Iqbal , J. 2009 . Garlic; nature's protection against physiological threats . Crit. Rev. Food Sci. Nutr. , 49 : 538 – 551 .
  • Capasso , R. , Izzo , A. A. , Borrelli , F. , Russo , A. , Sautebin , L. , Pinto , A. , Capasso , F. and Mascolo , N. 2002 . Effect of Piperine, the active ingredient of black pepper, on intestinal secretion of mice . Life Sci. , 71 : 2311 – 2317 .
  • Chaudhry , N. M. A. and Tariq , P. 2006 . Bactericidal activity of black pepper, bay leaf, aniseed and coriander against oral isolates . Pak. J. Pharm. Sci. , 19 : 214 – 218 .
  • Chonpathompikunlert , P. , Wattanathorn , J. and Muchimapura , S. 2010 . Piperine: The main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease . Food Chem. Toxicol. , 48 : 798 – 802 .
  • Christine , M. and Kaefer , J. A. M. 2008 . The role of herbs and spices in cancer prevention . J. Nutr. Biochem. , 19 : 347 – 361 .
  • Dearlove , R. P. , Greenspan , P. , Hartle , D. K. , Swanson , R. B. and Hargrove , J. L. 2008 . Inhibition of protein glycation by extracts of culinary herbs and spices . J. Med. Food. , 11 : 275 – 281 .
  • De-Souza , E. L. , Stamford , T. L. M. , Lima , E. O. , Trajano , V. N. and Filho , J. M. B. 2005 . Antimicrobial effectiveness of spices: An approach for use in food conservation systems . Braz. Arch. Biol. Technol. , 48 : 549 – 558 .
  • Dorman , H. J. D. and Deans , S. G. 2000 . Antimicrobial agents from plants: Antibacterial activity of plant volatile oils . J. Appl. Microbiol. , 88 : 308 – 316 .
  • Duessel , S. , Heuertz , R. M. and Ezekiel , U. R. 2008 . Growth inhibition of human colon cancer cells by plant compounds . Clin. Lab. Sci. , 21 : 151 – 157 .
  • Ebihara , T. , Ebihara , S. , Maruyama , M. , Kobayashi , M. , Itou , A. , Arai , H. and Sasaki , H. 2006 . A randomized trial of olfactory stimulation using black pepper oil in older people with swallowing dysfunction . JAGS. , 54 : 1401 – 1406 .
  • Edmondson , D. E. , Binda , C. and Mattevi , A. 2007 . Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B . Arch. Biochem. Biophys. , 464 : 269 – 276 .
  • Ee , G. C. , Lim , C. M. , Rahmani , M. , Shaari , K. and Bong , C. F. 2010 . Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum . Molecules. , 15 : 2398 – 2404 .
  • Eldershaw , T. P. , Colquhoun , E. Q. , Bennett , K. L. , Dora , K. A. and Clark , M. G. 1994 . Resiniferatoxin and piperine: Capsaicin-like stimulators of oxygen uptake in the perfused rat hind limb . Life Sci. , 55 : 389 – 397 .
  • Ferreira , S. R. S. and Meireles , M. A. A. 2002 . Modeling the supercritical fluid extraction of black pepper Piper Nigrum L. essential oil . J. Food Engg. , 54 : 263 – 269 .
  • Filley , C. M. 1995 . Alzheimer's disease: It's irreversible but not untreatable . Geriatrics. , 50 : 18 – 23 .
  • Fleischauer , A. T. , Poole , C. and Arab , L. 2000 . Garlic consumption and cancer prevention: Metaanalyses of colorectal and stomach cancers . Am. J. Clin. Nutr. , 72 : 1047 – 1052 .
  • Fu , M. , Sun , Z. H. and Zuo , H. C. 2010 . Neuroprotective effect of piperine on primarily cultured hippocampal neurons . Biol. Pharm. Bull. , 33 : 598 – 603 .
  • Galli , R. L. , Shukitt-Hale , B. , Youdim , K. A. and Joseph , J. A. 2002 . Fruit polyphenolics and brain aging: Nutritional interventions targeting age-related neuronal and behavioral deficits . Ann. N. Y. Acad. Sci. , 959 : 128 – 132 .
  • Gbewonyo , W. S. K. , Candy , D. J. and Anderson , M. 1993 . Structure activity relationships of insecticidal amides from Piper Guineese root . J. Pestic. Sci. , 37 : 57 – 66 .
  • George , K. M. , Joy , M. T. , Chandran , C. V. and Verghese , J. 1988 . The angular rotation of black pepper oil . Indian Perfum. , 32 : 51 – 54 .
  • Gulçin , I. 2005 . The antioxidant and radical scavenging activities of black pepper (Piper Nigrum) seeds . Int. J. Food Sci. Nutr. , 56 : 491 – 499 .
  • Gupta , S. K. , Bansal , P. , Bhardwaj , R. K. and Velpandian , T. 2000 . Comparative antinociceptive, anti-inflammatory and toxicity profile of nimesulide vs nimesulide and piperine combination . Pharmacol. Res. , 41 : 657 – 662 .
  • Han , Y. , Chin , T. T. M. and Lim , L. Y. 2008 . In vitro and in vivo evaluation if the effects of piperine on P-GP function and expression . Toxicol. Appl. Pharmacol. , 230 : 283 – 289 .
  • Hanumanthachar , J. and Miland , P. 2005 . Effects of piperine on memory and behavior mediated via monoamine neurotransmitters . J. Trad. Med. , 22 : 39 – 43 .
  • Hlavackova , L. , Urbanova , A. , Ulicna , O. , Janega , P. , Cerna , A. and Babal , P. 2010 . Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition . Bratisl. Lek. Listy. , 111 : 426 – 431 .
  • Hu , Y. , Liao , H. B. , Liu , P. , Guo , D. H. and Wang , Y. Y. 2009 . Antidepressant effects of piperine and its neuroprotective mechanism in rats . Zhong. Xi. Yi. Jie. He. Xue. Bao. , 7 : 667 – 670 .
  • Irani , F. 2005 . An encounter with ayurveda aromatherapy . J. Aromather. , 3 : 29 – 35 .
  • Irkin , R. and Korukluoglu , M. 2009 . Growth inhibition of pathogenic bacteria and some yeasts by selected essential oils and survival of L. monocytogenes and C. albicans in apple-carrot juice . Foodborne Pathog. Dis. , 6 : 387 – 394 .
  • Ishida , T. , Ishizaki , M. , Tsutsumi , S. , Ishii , Y. and Yamada , H. 2008 . Piperine, a pepper ingredient, improves the hepatic increase in free fatty acids caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin . J. Health Sci. , 545 : 551 – 558 .
  • Jabeen , B. , Badaruddin , M. , Ali , R. and Haleem , D. J. 2007 . Attenuation of restraintinduced behavioral deficits and serotonergic responses by stabilized rice bran in rats . Nutr. Neurosci. , 10 : 11 – 16 .
  • Janakiraman , K. and Manavalan , R. 2008 . Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin . Afr. J. Tradit. Complement. Altern. Med. , 5 : 257 – 262 .
  • Jin , M. J. and Han , H. K. 2010 . Effect of piperine, a major component of black pepper, on the intestinal absorption of fexofenadine and its implication on food-drug interaction . J. Food Sci. , 75 : H93 – H96 .
  • Jin , Z. , Borjihan , G. , Zhao , R. , Sun , Z. , Hammond , G. B. and Uryu , T. 2009 . Antihyperlipidemic compounds from the fruit of Piper Longum L . Phytother. Res. , 23 : 1194 – 1196 .
  • Jirovetz , L. , Buchbauer , G. , Ngassoum , M. B. and Geissler , M. 2002 . Aroma compound analysis of Piper Nigrum and Piper guineense essential oils from Cameroon using solid-phase microextraction-gas chromatography, solid-phase microextraction-gas chromatography-mass spectrometry and olfactometry . J. Chromatogr. A. , 976 : 265 – 275 .
  • Johri , R. K. , Thusu , N. , Khajuria , A. and Zutshi , U. 1992 . Piperine-mediated changes in the permeability of rat intestinal epithelial cells. The status of gamma-glutamyl transpeptidase activity, uptake of amino acids and lipid peroxidation . Biochem. Pharmacol. , 43 : 1401 – 1407 .
  • Kaefera , C. M. and Milne , J. A. 2008 . The role of herbs and spices in cancer prevention . J. Nutr. Biochem. , 19 : 347 – 361 .
  • Kapoor , I. P. S. , Singh , B. , Singh , G. , De-Heluani , C. S. , De-Lampasona , M. P. and Catalan , C. A. N. 2009 . Chemistry and in vitro antioxidant activity of volatile oil and oleoresins of black pepper (Piper Nigrum) . J. Agric. Food Chem. , 57 : 5358 – 5364 .
  • Karsha , P. V. and Lakshmi , O. B. 2010 . Antibacterial activity of black pepper Piper Nigrum Linn. with special reference to its mode of action on bacteria . Indian J. Nat. Prod. Resour , 1 : 213 – 215 .
  • Kessler , R. C. , McGonagle , K. A. , Zhao , S. , Nelson , C. B. , Hughes , M. and Eshleman , S. 1994 . Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey . Arch. Gen. Psych. , 51 : 8 – 19 .
  • Kobayashi , A. , Watanabe , J. , Fukushi , E. , Kawabata , J. , Nakajima , M. and Watanabe , M. 2003 . Polyphenols from some foodstuffs as inhibitors of ovalbumin permeation through caco-2 cell monolayers . Biosci. Biotechnol. Biochem. , 67 : 1250 – 1257 .
  • Kong , L. D. , Cheng , C. H. and Tan , R. X. J. 2004 . Inhibition of MAO A and B by some plant- derived alkaloids, phenols and anthraquinones . J. Ethnopharmacol , 91 : 351 – 355 .
  • Koul , I. B. and Kapil , A. 1993 . Evaluation of the liver protective potential of piperine, an active principle of black and long peppers . Planta Med , 59 : 413 – 417 .
  • Krishnakumar , N. , Manoharan , S. , Palaniappan , P. R. , Venkatachalam , P. and Manohar , M. G. 2009 . Chemopreventive efficacy of piperine in 7,12-dimethyl benzz [a] anthracene (DMBA)-induced hamster buccal pouch carcinogenesis: An FT-IR study . Food Chem. Toxicol. , 47 : 2813 – 2820 .
  • Kumoro , A. C. , Singh , H. and Hasan , M. 2009 . Solubility of piperine in supercritical and near critical carbon dioxide . J. Chem. Engg. , 17 : 1014 – 1020 .
  • Lambert , J. D. , Hong , J. , Kim , D. H. , Mishin , V. M. and Yang , C. S. 2004 . Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice . J. Nutr. , 134 : 1948 – 1952 .
  • Lee , C. S. , Han , E. S. and Kim , Y. K. 2006 . Piperine inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells . Eur. J. Pharmacol. , 537 : 37 – 44 .
  • Lee , S. A. , Hong , S. S. , Han , X. H. , Hwang , J. S. , Oh , G. J. , Lee , K. S. , Lee , M. K. , Hwang , B. Y. and Ro , J. S. 2005 . Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity . Chem. Pharm. Bull. , 53 : 832 – 835 .
  • Lee , S. A. , Hwang , J. S. , Han , X. H. , Lee , C. , Lee , M. H. , Choe , S. G. , Hong , S. S. , Lee , D. , Lee , M. K. and Hwang , B. Y. 2008 . Methylpiperate derivatives from Piper longum and their inhibition of monoamine oxidase . Arch. Pharm. Res. , 31 : 679 – 683 .
  • Lee , S. J. , Umano , K. , Shibamoto , T. and Lee , K. G. 2004 . Identification of volatile components in basil Ocimum basilicum L. and thyme leaves Thymus Vulgaris L. and their antioxidant properties . Food Chem. , 91 : 131 – 137 .
  • Li , S. , Wang , C. , Wang , M. W. , Li , W. , Matsumoto , K. and Tang , Y. Y. 2007 . Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms . Life Sci , 80 : 1373 – 1381 .
  • Liao , H. , Liu , P. , Hu , Y. , Wang , D. and Lin , H. 2009 . Antidepressant-like effects of piperine and its neuroprotective mechanism . Zhongguo Zhong Yao Za Zhi. , 34 : 1562 – 1565 .
  • Lin , Z. , Liao , Y. , Venkatasamy , R. , Hider , R. C. and Soumyanath , A. 2007 . Amides from Piper Nigrum L. with dissimilar effects on melanocyte proliferation in-vitro . J. Pharm. Pharmacol. , 59 : 529 – 536 .
  • Liston , D. R. , Nielsen , J. A. , Villalobos , A. , Chapin , D. , Jones , S. B. , Hubbard , S. T. , Shalaby , I. A. , Ramirez , A. , Nason , D. and White , W. F. 2004 . Pharmacology of selective acetylcholinesterase inhibitors: Implications for use in Alzheimer's disease . Eur. J. Pharmacol. , 486 : 9 – 17 .
  • Liu , F. and Ng , T. B. 2000 . Antioxidative and free radical scavenging activities of selected medicinal herbs . Life Sci. , 66 : 725 – 735 .
  • Liu , Y. , Yadev , V. R. , Aggarwal , B. B. and Nair , M. G. 2010 . Inhibitory effects of black pepper (Piper Nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B . Nat. Prod. Commun. , 5 : 1253 – 1257 .
  • MacKinno , S. , Chauret , D. , Wang , M. , Mata , R. , Pereda-Miranda , R. , Jiminez , A. , Bernard , C. B. , Krishnamurty , H. G. , Poveda , L. J. , Sanchez-Vindaz , P. E. , Arnason , J. T. and Durst , T. 1997 . Botanicals from the piperaceae and meliaceae of the american neotrpoics: Phytochemistry: Phytochemicals for pest control . ACS Symposium Series , 658 : 49 – 57 .
  • Majdalawieh , A. F. and Carr , R. I. 2010 . In vitro investigation of the potential immunomodulatory and anti-cancer activities of black pepper (Piper Nigrum) and cardamom (Elettaria cardamomum) . J. Med. Food. , 13 : 371 – 381 .
  • Manoharan , S. , Balakrishnan , S. , Menon , V. P. , Alias , L. M. and Reena , A. R. 2009 . Chemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenzz[a]anthracene-induced hamster buccal pouch carcinogenesis . Singapore Med. J. , 50 : 139 – 146 .
  • McDonnell , M. G. and Archbold , G. P. R. 1996 . Plasma ubiquinol/cholesterol ratios in patients with hyperlipidemia, those with diabetes mellitus and in patients requiring dialysis . Clin. Chim. Acta. , 253 : 117 – 126 .
  • Mc-Mahon , J. B. , Currens , M. J. , Gulakowski , R. J. , Buckheit , R. W. J. , Lackman-Smith , C. , Hallock , Y. F. and Boyd , M. R . 1995 . Michellamine B, novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by at least two distinct mechanisms . Antimicrob. Agents Chemother. , 39 : 484 – 488 .
  • McNamara , F. N. , Randall , A. and Gunthorpe , M. J. 2005 . Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1) . Br. J. Pharmacol. , 144 : 781 – 790 .
  • Mehmood , M. H. and Gilani , A. H. 2010 . Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders . J. Med. Food. , 13 : 1086 – 1096 .
  • Mittal , R. and Gupta , R. L. 2000 . In vitro antioxidant activity of piperine . Methods Find Exp. Clin. Pharmacol , 22 : 271 – 274 .
  • Mohandes , K. M. and Desai , D. C. 1999 . Epidemiology of digestive tract cancer in India v. large and small bowel . Indian J. Gastroenterol. , 18 : 118 – 121 .
  • Mohit , K. B. , Mahendra , B. and Shrinivas , K. K. 2009 . Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes . Pharm. Biochem. Behav. , 92 : 39 – 43 .
  • Monika , M. , Stefanie , H. and Alois , J. 2010 . Anti-inflammatory activity of extracts from fruits, herbs and spices . Food Chem , 122 : 987 – 996 .
  • Mueller , M. , Beck , V. and Jungbauer , A. 2011 . PPARα activation by culinary herbs and spices . Planta Med , [In press]
  • Mujumdar , A. M. , Dhuley , J. N. , Deshmukh , V. K. , Raman , P. H. and Naik , S. R. 1990 . Anti-inflammatory activity of piperine . Jpn. J. Med. Biol. , 43 : 95 – 100 .
  • Murthy , C. T. and Bhattacharya , S. 2008 . Cryogenic grinding of black pepper . J. Food Eng. , 85 : 18 – 28 .
  • Musenga , A. , Mandrioli , R. , Ferranti , A. , D’Orazio , G. , Fanali , S. and Raggi , M. A. 2007 . Analysis of aromatic and terpenic constituents of pepper extracts by capillary electrochromatography . J. Sep. Sci. , 30 : 612 – 619 .
  • Nakatani , N. , Inatani , R. , Ohta , H. and Nishioka , A. 1986 . Chemical constituents of peppers piper spp. and application to food preservation: Naturally occurring antioxidative compounds . Environ. Health Perspect. , 67 : 135 – 142 .
  • Nalini , N. , Sabitha , K. , Viswanathan , P. and Menon , V. P. 1998 . Influence of spices on the bacterial (enzyme) activity in experimental colon cancer . J. Ethnopharmacol. , 62 : 15 – 24 .
  • Naseri , M. K. and Yahyavi , H. 2008 . Antispasmodic effect of Piper Nigrum fruit hot water extract on rat ileum . Pak. J. Biol. Sci. , 11 : 1492 – 1496 .
  • Nisha , P. , Singhal , R. S. and Pandit , A. B. 2009 . The degradation kinetics of flavor in black pepper (Piper Nigrum L) . J. Food Eng. , 92 : 44 – 49 .
  • Okumura , Y. , Narukawa , M. , Iwasaki , Y. , Ishikawa , A. , Matsuda , H. , Yoshikawa , M. and Watanabe , T. 2010 . Graduate school of nutritional and environmental sciences, University of Shizuoka, Shizouka, Japan. Activation of TRPV1 and TRPA1 by black pepper components . Biosci. Biotechnol. Biochem. , 74 : 68 – 72 .
  • Ononiwu , I. M. , Ibeneme , C. E. and Ebong , O. O. 2002 . Effects of piperine on gastric acid secretion in albino rats . Afr. J. Med. Med. Sci. , 31 : 293 – 295 .
  • Orav , A. , Stulova , I. , Kailas , T. and Muurisepp , M. 2004 . Effect of storage on the essential oil composition of Piper Nigrum L. fruits of different ripening states . J. Agric. Food Chem. , 52 : 2582 – 2586 .
  • Parmar , V. S. , Jain , S. C. , Bisht , K. S. , Jain , R. , Taneja , P. , Jha , A. , Tyagi , O. D. , Prasad , A. K. , Wengel , J. , Olsen , C. E. and Boll , P. M. 1997 . Phytochemistry of the genus piper . Photochemistry. , 46 : 597 – 673 .
  • Pattanaik , S. , Hota , D. , Prabhakar , S. , Kharbanda , P. and Pandhi , P. 2006 . Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy . Phytother. Res. , 20 : 683 – 686 .
  • Pattanaik , S. , Hota , D. , Prabhakar , S. , Kharbanda , P. and Pandhi , P. 2009 . Pharmacokinetic interaction of single dose of piperine with steady-state carbamazepine in epilepsy patients . Phytother. Res. , 23 : 1281 – 1286 .
  • Platel , K. , Rao , A. , Saraswathi , G. and Srinivasan , K. 2003 . Digestive stimulant action of three indian spices mixes in experimental rats . Nahrung. , 46 : 394 – 398 .
  • Politeo , O. , Jukic , M. and Milos , M. 2006 . Chemical composition and antioxidant activity of essential oils of twelve spice plants . Croat. Chem. Acta. , 79 : 545 – 552 .
  • Polovka , M. and Suhaj , M. 2010 . The effect of irradiation and heat treatment on composition and antioxidant properties of culinary herbs and spices. A Review . Food Rev. Int. , 26 : 138 – 161 .
  • Prakash , U. N. and Srinivasan , K. 2010 . Gastrointestinal protective effect of dietary spices during ethanol-induced oxidant stress in experimental rats . Appl. Physiol. Nutr. Metab. , 35 : 134 – 141 .
  • Ramasamy , S. V. and Namasivayam , N. 2006 . Efficacy of piperine, an alkaloidal constituent from Piper Nigrum on erythrocyte antioxidant status in high fat diet and antithyroid drug induced hyperlipidemic rats . Cell Biochem. Func. , 24 : 491 – 498 .
  • Ravindran , P. N. and Johnny , A. K. 2000 . High yielding varieties in spices . Indian Spices , 37 : 17 – 19 .
  • Rauscher , F. M. , Sanders , R. A. and Watkins , J. B. 2007 . Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats . J. Biochem. Mol. Toxicol. , 14 : 329 – 334 .
  • Reen , R. K. , Wiebel , F. J. and Singh , J. 1997 . Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1 . J. Ethnopharmacol. , 58 : 165 – 173 .
  • Renjie , L. , Shidi , S. and Yongjun , M. 2010 . Analysis of volatile oil composition of the peppers from different production areas . Med. Chem. Res. , 19 : 157 – 165 .
  • Sabina , E. P. , Nagar , S. and Rasool , M. 2011 . A role of piperine on monosodium urate crystal-induced inflammation-an experimental model of gouty arthritis . Inflammation. , 34 : 184 – 192 .
  • Sangwan , P. L. , Koul , J. L. , Koul , S. , Reddy , M. V. , Thota , N. , Khan , I. A. , Kumar , A. , Kalia , N. P. and Qazi , G. N. 2008 . Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors . Bioorg. Med. Chem. , 16 : 9847 – 9857 .
  • Saraswat , M. , Muthenna , P. , Suryanarayana , P. , Petrash , J. M. and Reddy , G. B. 2008 . Dietary sources of aldose reductase inhibitors: Prospects for alleviating diabetic complications . Asia. Pac. J. Clin. Nutr. , 17 : 558 – 565 .
  • Saraswat , M. , Reddy , P. Y. , Muthenna , P. and Reddy , G. B. 2009 . Prevention of non-enzymic glycation of proteins by dietary agents: Prospects for alleviating diabetic complications . Br. J. Nutr. , 101 : 1714 – 1721 .
  • Saxena , R. , Venkaiah , K. , Anitha , P. , Venu , L. and Raghunath , M. 2007 . Antioxidant activity of commonly consumed plant foods of India: Contribution of their phenolic content . Int. J. Food Sci. Nutr. , 58 : 250 – 260 .
  • Schecter , A. , Birnbaum , L. , Ryan , J. J. and Constable , J. D. 2006 . Dioxins: An overview . Environ. Res. , 101 : 419 – 428 .
  • Scott , I. M. , Puniani , E. , Durst , T. , Phelps , D. , Merali , S. , Assabgui , R. A. , Sanchez-Vindas , P. , Poveda , l. , Philgene , B. J. R. and Arnason , J. T. 2002 . Insecticidal activity of piper tuberculatum. extract: Synergistic interaction of piperamides . Agric. Forest Entamol. , 4 : 137 – 144 .
  • Seifried , H. E. , Anderson , D. E. , Fisher , E. I. and Milner , J. A. 2007 . A review of the interaction among dietary antioxidants and reactive oxygen species . J. Nut. Biochem. , 18 : 567 – 579 .
  • Selvendiran , K. , Mumtaz Banu , S. and Sakthisekaran , D. 2004 . Protective effect of piperine on benzoo [a] pyrene-induced lung carcinogenesis in Swiss albino mice . Clin. Chim. Acta. , 350 : 73 – 78 .
  • Selvendiran , K. and Sakthisekaran , D. 2004 . Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a)pyrene induced lung carcinogenesis . Biomed. Pharmacother. , 58 : 264 – 267 .
  • Selvendiran , K. , Singh , J. P. , Krishnan , K. B. and Sakthisekaran , D. 2003 . Cytoprotective effect of piperine against benzoo[a]pyrene induced lung cancer with reference to lipid peroxidation and antioxidant system in swiss albino mice . Fitoterapia. , 74 : 109 – 115 .
  • Selvendiran , K. , Singh , J. P. and Sakthisekaran , D. 2006 . In vivo effect of piperine on serum and tissue glycoprotein levels in benzoo [a] pyrene induced lung carcinogenesis in Swiss albino mice . Pulm. Pharmacol. Ther. , 19 : 107 – 111 .
  • Selvendiran , K. , Thirunavukkarasu , C. , Singh , J. P. , Padmavathi , R. and Sakthisekaran , D. 2005 . Chemopreventive effect of piperine on mitochondrial TCA cycle and phase-i and glutathione-metabolizing enzymes in benzoapyrene induced lung carcinogenesis in swiss albino mice . Mol. Cell Biochem. , 271 : 101 – 116 .
  • Shaikh , J. , Bhosale , R. and Singhal , R. 2006 . Microencapsulation of black pepper oleoresin . Food Chem , 94 : 105 – 110 .
  • Shankaracharya , N. B. , Rao , L. J. , Naik , J. P. and Nagalakshmi , S. 1997 . Characterisation of chemical constituents of indian long pepper Piper Longum L . J. Food Sci. Technol. Mysore. , 34 : 73 – 75 .
  • Singh , G. , Marimuthu , P. , Murali , H. S. and Bawa , A. S. 2005 . Antioxidative and antibacterial potentials of essential oils and extracts isolated from various spice materials . J. Food Safety. , 25 : 130 – 145 .
  • Singletary , K. 2010 . Black pepper: Overview of health benefits . Food Sci , 45 : 43 – 47 .
  • Sloan , A. E. 2005 . Top 10 global food trends . Food Technol , 59 : 20 – 32 .
  • Snyman , T. , Stewart , M. J. and Steenkamp , V. 2001 . A fatal case of pepper poisoning . Forensic. Sci. Int. , 124 : 43 – 46 .
  • Soumyanath , A. , Venkatasamy , R. , Joshi , M. , Faas , L. , Adejuyigbe , B. , Drake , A. , Hider , R. C. and Young , A. R. 2006 . UV Irradiation affects melanocyte stimulatory activity and protein binding of piperine . Photochem. Photobiol. , 82 : 1541 – 1548 .
  • Sowbhagya , H. B. , Sampathu , S. R. , Krishnamurthy , N. and Shankaranarayana , M. L. 1990 . Stability of piperine in different solvents and its spectrophotometric estimation . Ind. Spices. , 27 : 21 – 23 .
  • Srinivasan , K. 2005a . Role of Spices beyond food flavouring: nutraceuticals with multiple health effects . Food Rev. Int. , 21 : 167 – 188 .
  • Srinivasan , K. 2005b . Spices as influencers of body metabolism: An overview of three decades of research . Food Res. Int. , 38 : 77 – 86 .
  • Srinivasan , K. 2007 . Black pepper and its pungent principle-piperine: A review of diverse physiological effects . Crit. Rev. Food Sci. Nutr. , 47 : 735 – 748 .
  • Srinivasan , K. 2008 . Reason to Season: Spices as functional food adjuncts with multiple health effects . Ind. Food Indus. , 27 : 36 – 47 .
  • Srinivasan , K. , Sambaiah , K. and Chandrasekhara , N. 2004 . Spices as beneficial hypolipidemic food adjuncts: A Review . Food Rev. Int. , 20 : 187 – 220 .
  • Stohr , J. R. , Xiao , P. G. and Bauer , R. 2001 . Constituents of Chinese Piper species and their inhibitory activity on prostaglandin and leukotriene biosynthesis in vitro . J. Ethnopharmacol. , 75 : 133 – 139 .
  • Su , L. , Yin , J. J. , Charles , D. , Zhou , K. , Moore , J. and Yu , L. 2007 . Total phenolic contents, chelating capacities, and radical-scavenging properties of black peppercorn, nutmeg, rosehip, cinnamon and oregano leaf . Food Chem. , 100 : 990 – 997 .
  • Suresh , D. and Srinivasan , K. 2006 . Influence of curcumin, capsaicin, and piperine on the rat liver drug-metabolizing enzyme system in vivo and in vitro . Can. J. Physiol. Pharmacol. , 84 : 1259 – 1265 .
  • Suresh , D. and Srinivasan , K. 2007 . Studies on the in vitro absorption of spice principles–curcumin, capsaicin and piperine in rat intestines . Food Chem. Toxicol. , 45 : 1437 – 1442 .
  • Suresh , D. and Srinivasan , K. 2010 . Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats . Ind. J. Med. Res. , 131 : 682 – 691 .
  • Szallasi , A. 2005 . Piperine: Researchers discover new flavor in an ancient spice . Trends Pharmacol. Sci. , 26 : 437 – 439 .
  • Tachakittirungrod , S. , Okonogi , S. and Chowwanapoonpoh , S. 2007 . Study on antioxidant activity of certain plants in thailand. Mechanism of antioxidant action of guava leaf extract . Food Chem. , 103 : 381 – 388 .
  • Taqvi , S. I. , Shah , A. J. and Gilani , A. H. 2008 . Blood pressure lowering and vasomodulator effects of piperine . J. Cardiovasc. Pharmacol. , 52 : 452 – 458 .
  • Thanuja , T. V. , Hedge , R. V. and Sreenivasa , M. N. 2002 . Induction of rooting and root growth in black pepper cuttings (Piper Nigrum L) with inoculation of arbuscular mycorrhizae . Sci. Hort. , 92 : 339 – 346 .
  • Thirunavukkarasu , C. , Singh , J. P. V. , Selvendiran , K. and Sakthisekaran , D. 2001 . Chemopreventive efficacy of selenium against N-nitrosodiethylamine-induced hepatoma in albino rats . Cell Biochem. Funct. , 19 : 265 – 271 .
  • Tipsrisukond , N. , Fernando , L. N. and Clarke , A. D. 1998 . Antioxidant effects of essential oil and oleoresin of black pepper from supercritical carbon dioxide extractions in ground pork . J. Agric. Food Chem. , 46 : 4329 – 4333 .
  • Utpala , P. , Asish , G. R. , Zachariah , T. J. , Saji , K. V. , Johnson , K. G. and Mathew , P. A. 2008 . Spatial influence on the important biochemical properties of Piper Nigrum linn leaves . Nat. Prod. Radiance. , 7 : 444 – 447 .
  • Vellaichamy , L. , Balakrishnan , S. , Panjamurthy , K. , Manoharan , S. and Alias , L. M. 2009 . Chemopreventive potential of piperine in 7,12-dimethylbenzz[a]anthracene induced skin carcinogenesis in Swiss albino mice . Environ. Toxicol. Pharmacol. , 28 : 11 – 18 .
  • Venkatasamy , R. , Faas , L. , Young , A. R. , Raman , A. and Hider , R. C. 2004 . Effects of piperine analogues on stimulation of melanocytes proliferation and melanocyte differentiation . Bioorganic Med. Chem. , 12 : 1905 – 1920 .
  • Vijayakumar , R. S. and Nalini , N. 2006 . Efficacy of piperine, an alkaloidal constituent from Piper Nigrum on erythrocyte antioxidant status in high fat diet and antithyroid drug induced hyperlipidemic rats . Cell Biochem. Function. , 24 : 491 – 498 .
  • Vijayakumar , R. S. , Surya , D. and Nalini , N. 2004 . Antioxidant efficacy of black pepper (Piper Nigrum L.) and piperine in rats with high fat diet induced oxidative stress . Redox. Rep. , 9 : 105 – 110 .
  • Volak , L. P. , Ghirmai , S. , Cashman , J. R. and Court , M. H. 2008 . Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor . Drug Metab. Dispos. , 36 : 1594 – 1605 .
  • Wattanathorn , J. , Chonpathompikunlert , P. , Muchimapura , S. , Priprem , A. and Tankamnerdthai , O. 2008 . Piperine, the potential functional food for mood and cognitive disorders . Food Chem. Toxicol. , 46 : 3106 – 3110 .
  • Weerakkody , N. S. , Caffin , N. , Turner , M. S. and Dykes , G. A. 2010 . In vitro antimicrobial activity of less-utilized spice and herb extracts against selected food-borne bacteria . Food Control. , 21 : 1408 – 1414 .
  • Wood , A. B. , Barrow , M. L. and James , D. J. 1988 . Piperine determination in pepper Piper Nigrum L. and its oleoresins: A reversed phase high performance liquid chromatographic method . J. Flavour Frag. , 3 : 55 – 64 .
  • Yadav , A. S. and Bhatnagar , D. 2007 . Modulatory effect of spice extracts on iron-induced lipid peroxidation in rat liver . Biofactors. , 29 : 147 – 157 .
  • Youdim , K. A. , Spencer , J. P. , Schroeter , H. and Rice-Evans , C. 2002 . Dietary flavonoids as potential neuroprotectants . Biol. Chem. , 383 : 503 – 519 .
  • Zachariah , T. J. and Parthasarathy , V. A. 2008 . “ Black pepper ” . In Chemistry of Spices , Edited by: Parthasarathy , V. A. , Chempakam , B. and Zachariah , T. J. 21 – 40 . UK : CABI .
  • Zachariah , T. J. , Safeer , A. L. , Jayarajan , K. , Leela , N. K. , Vipin , T. M. , Saji , K. V. , Shiva , K. N. , Parthasarathy , V. A. and Mammootty , K. P. 2010 . Correlation of metabolites in the leaf and berries of selected black pepper varieties . Sci. Horti. , 123 : 418 – 422 .
  • Zarotsky , V. , Sramek , J. J. and Cutler , N. R. 2003 . Galantamine hydrobromide: An agent for Alzheimer's disease . Am. J. Health Syst. Pharm. , 60 : 446 – 452 .
  • Zhou , S. , Gao , Y. , Jiang , W. , Huang , M. , Xu , A. and Paxton , J. W. 2003 . Interactions of herbs with cytochrome . Drug Metab. Rev. , 35 : 35 – 98 .

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