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Original Articles

Micronutrient and Functional Compounds Biofortification of Maize Grains

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REFERENCES

  • Adom, K.K. and Liu, R.H. (2002). Antioxidant activity of grains. J. Agr. Food Chem. 50:6182–6187.
  • Aluru, M., Xu, Y., Guo, R., Wang, Z., Li, S., White, W., Wang, C. and Rodermel, S. (2008). Generation of transgenic maize with enhanced provitamin A content. J. Exp. Bot. 59:3551–3562.
  • Anderson, J.W., Hanna, T.J., Peng, X. and Kryscio, R.J. (2000). Whole grain foods and heart disease risk. J. Am. Coll. Nutr. 19:291S–299S.
  • Anjaneyulu, M. and Chopra, K. (2004). Nordihydroguairetic acid, a lignin, prevents oxidative stress and the development of diabetic nephropathy in rats. Pharmacology. 72:42–50.
  • Anttonen, M.J., Hoppula, K.I., Nestby, R., Verheul, M.J. and Karjalainen, R.O. (2006). Influence of fertilization, mulch color, early forcing, fruit order, planting date, shading, growing environment, and genotype on the contents of selected phenolics in strawberry (Fragaria × ananassa Duch.) Fruits. J. Agric. Food Chem. 54:2614–2620.
  • Araújo, P.M. and Nass, L.L. (2002). Characterization and evaluation of maize landraces. Scientia Agrícola. 59:589–593.
  • Bansal, A.K., Bansal, M., Soni, G. and Bhatnagar, D. (2005). Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. Chem. Biol. Interact. 156:101–111.
  • Begum, A.N., Nicolle, C., Mila, I., Lapierre, C., Nagano, K., Fukushima, K., Heinonen, S.M., Adlercreutz, H., Remesy, C. and Scalbert, A. (2004). Dietary lignins are precursors of mammalian lignans in rats. J. Nutr. 134:120–127.
  • Belal, S., Hassan, N. and Mansour, A. (2009). Histopathological and stereological studies for evaluation of Aeromonas hydrophila-induced pulmonary structural changes with emphasis on the possible protective effect of inositol hexaphosphate. Adv. Biol. Res. 3:222–230.
  • Berardo, N., Mazzinelli, G., Valoti, P., Lagana, P. and Redaellij, R. (2009). Characterization of maize germplasm for the chemical composition of the grain. Agr. Food Chem. 57:2378–2384.
  • Brakemeier, C. (1999). Adubação foliar: A complementação nutricional da macieira. Jornal da Fruta. Lajes, 7.
  • Brandt, K. and Mølgaard, J.P. (2001). Organic agriculture: Does it enhance or reduce the nutritional value of plant foods? J. Sci. Food Agr. 81:924–931.
  • Broadley, M.R., White, P.J., Bryson, R.J., Meacham, M.C., Bowen, H.C., Johnson, S.E., Hawkesford, M.J., Mcgrath, S.P., Zhao, F.J., Breward, N., Harriman, M. and Tucker, M. (2006). Biofortification of UK food crops with selenium. Proc. Nutr. Soc. 65:169–181.
  • Brown, L., Rimm, E.B., Seddon, J.M., Giovannucci, E.L., Chasan-Taber, L., Spiegelman, D., Willett, W.C. and Hankinson, S.E. (1999). A prospective study of carotenoid intake and risk of cataract extraction in US men. Am. J. Clin. Nutr. 70:431–432.
  • Bunzel, M., Ralph, J., Martia, J.M., Hatfield, R.D. and Steinhart, H. (2001). Diferulates as structural components in soluble and insoluble cereal dietary fibre. J. Sci. Food Agr. 81:653–660.
  • Cahoon, E.B., Hall, S.E., Ripp, K.G., Ganzke, T.S., Hitz, W.D. and Coughlan, S.J. (2003). Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content. Nat. Biotechnol. 21:1082–1087.
  • Cakmak, I. (2008). Enrichment of cereal grains with zinc: Agronomic or genetic biofortification? Plant Soil. 302:1–17.
  • Chandler, V.L., Radicella, J.P., Robbins, T.P., Chen, J. and Turks, D. (1989). Two regulatory genes of the maize anthocyanin pathway are homologous: Isolation of B utilizing R genomic sequences. Plant Cell. 1:1175–1183.
  • Chen, Z., Young, T.E., Ling, J., Chang, S.C. and Gallie, D.R. (2003). Increasing vitamin C content of plants through enhanced ascorbate recycling. Proc. Nat. Acad. Sci. U S A. 100:3525–30.
  • Ciappellano, S., Testolin, G. and Porrini, M. (1989). Effects of durum wheat dietary selenium on glutathione peroxidase activity and Se content in longterm- fed rats. Ann. Nutr. Metab. 33:22–30.
  • Cogo, S.L. P., Chaves, F.C., Schirmer, M.A., Zambiazi, R.C., Nora, L., Silva, J.A. and Rombaldi, C.V. (2011). Low soil water content during growth contributes to preservation of green colour and bioactive compounds of cold-stored broccoli (Brassica oleracea L.) florets. Postharvest Biol. Tec. 60:158–163.
  • Combs G.F. Jr. (2001). Selenium in global food systems. Brit. J. Nutr. 85:517–547.
  • Cooke, M.S., Evans, M.D., Mistry, N. and Lunec, J. (2002). Role of dietary antioxidants in the prevention of in vivo oxidative DNA damage. Nutr. Res. Rev. 15:19–41.
  • Cukelj, N., Novotni, D. and Ćurić, D. (2010). Antioxidant properties of whole grain cereals. Croat. J. Food Technol. Biotech. Nutr. 5:18–23.
  • Curie, C., Panaviene, Z., Loulergue, C., Dellaporta, S.L., Briat, J. and Walker, E.L. (2001). Maize yellow stripe1 encodes a membrane protein directly involved in Fe (III) uptake. Nature. 409:346–349.
  • Curtin, D., Hanson, R., Lindley, T.N. and Butler, R.C. (2006). Selenium concentration in wheat (Triticum aestivum) grain as influenced by method, rate, and timing of sodium selenate application. New Zealand J. Crop Hort. 34:329–339.
  • De Boland, A.R., Garner, G.B. and O′Dell, B.L. (1975). Identification and properties of phytate in cereal grains and oilseed products. J. Agr. Food Chem. 23:1186–1189.
  • Del Pozo-Insfran, D., Brenes, C.H., Saldivar, S.O. S. and Talcott, S.T. (2006). Polyphenolic and antioxidant content of white and blue corn (Zea mays L.) products. Food Res. Int. 39:696–703.
  • De Oliveira, G.P. R. and Rodriguez-Amaya, D.B. (2007). Processed and prepared corn products as sources of lutein and zeaxanthin: Compositional variation in the food chain. J. Food Sci. 72:79–85.
  • Dewanto, V., Wu, X.Z. and Liu, R.H. (2002). Processed sweet corn has higher antioxidant activity. J. Agr. Food Chem. 50:4959–4964.
  • Dias, A.P. and Grotewold, E. (2003). Manipulating the accumulation of phenolics in maize cultured cells using transcription factors. Biochem. Eng. J. 14:207–216.
  • Didonato R.J. Jr, Roberts, L.A., Sanderson, T., Eisley, R.B. and Walker, E.L. (2004). Arabidopsis Yellow Stripe-Like2 (YSL2): A metal-regulated gene encoding a plasma membrane transporter of nicotianamine–metal complexes. Plant J. 39:403–414.
  • Dixon, R.A. and Pasinetti, G.M. (2010). Flavonoids and isoflavonoids. Plant biology to agriculture and neuroscience. J. Plant Physiol. 154:453–457.
  • Doria, E., Galleschi, L., Calucci, L., Pinzino, C., Pilu, R., Cassani, E. and Nielsen, E. (2009). Phytic acid prevents oxidative stress in seeds: Evidence from a maize (Zea mays L.) low phytic acid mutant. J. Exp. Bot. 60:967–978.
  • Drakakaki, G., Marcel, S., Glahn, R.P., Lund, E.K., Pariagh, S., Fischer, R., Christou, P. and Stoger, E. (2005). Endosperm-specific co-expression of recombinant soybean ferritin and Aspergillus phytase in maize results in significant increases in the levels of bioavailable iron. Plant Mol. Biol. 59:869–880.
  • Fang, Y., Wang, L., Xin, Z., Zhao, L., Na, X. and Hu, Q. (2008). Effect of foliar application of zinc, selenium, and iron fertilizers on nutrients concentration and yield of rice grain in China. J. Agr. Food Chem. 56:2079–2084.
  • Fanning, K.J., Martin, I., Wong, L., Keating, V., Puna, S. and O′Harec, T. (2010). Screening sweetcorn for enhanced zeaxanthin concentration. J. Sci. Food Agr. 90:91–96.
  • Faostate—Food And Agriculture Organization of the United Nations. (2009). . http://www.faostat.fao.org. Accessed May 9, 2011.
  • Fardet, A., Rock, E. and Rémésy, C. (2008). Is the in vitro antioxidant potential of whole-grain cereals and cereal products well reflected in vivo? J. Cereal Sci. 48:258–276.
  • Ferreira, A.C. B., Araújo, G.A. A., Roberto, P., Pereira, G. and Cardoso, A.A. (2001). Corn crop characteristics under nitrogen, molybdenum and zinc fertilization. Scientia Agricola. 58:131–138.
  • Feucht, W., Treutter, D., Bengsch, E. and Polster, J. (1999). Effects of water soluble boron and aluminium compounds on the synthesis of flavanols in grape vine callus. Z. Naturforsch. 54:942–945.
  • Flores, P., Hellin, P. and Fenoll, J. (2009). Effect of manure and mineral fertilization on pepper nutritional quality. J. Sci. Food Agr. 89:1581–1586.
  • Fraser, P.D. and Bramley, P.M. (2004). The biosynthesis and nutritional uses of carotenoids. Prog. Lipid Res. 43:228–265.
  • Frossard, E., Bucher, M., Machler, F., Mozafar, A. and Hurrell, F. (2000). Potential for increasing the content and bioavailability of Fe, Zn and Ca in plants for human nutrition. J. Sci. Food Agr. 80:861–879.
  • Fujimori, M., Hayashi, K., Hirata, M., Ikeda, S., Takahashi, Y., Mano, Y., Sato, H., Takamizo, T., Mizuno, K., Fujiwara, T., . Sugita, S. (2004). Molecular breeding and functional genomics for tolerance to biotic stress. Molecular breeding of forage and turf. Develop. Plant Breed. 11:21–35.
  • Gallagher, C.E., Matthews, P.D., Faqiang, L. and Wurtzel, E.T. (2004). Gene duplication in the carotenoid biosynthetic pathway preceded evolution of the grasses. Plant Physiol. 135:1776–1783.
  • Gallardo, C., Jimenez, L. and Garcia-Conesa, M.T. (2006). Hydroxycinnamic acid composition and in vitro antioxidant activity of selected grain fractions. Food Chem. 99:455–463.
  • Gautama, S., Kalpana, P. and Srinivanan, K. (2010). Influence of β-carotene-rich vegetables on the bioaccessibility of zinc and iron from food grains. Food Chem. 122:668–672.
  • Glahn, R.P. and Wortley, G.M. (2002). Inhibition of iron uptake by phytic acid, tannic acid, and ZnCl2: Studies using an in vitro digestion/Caco-2 cell model. J. Agr. Food Chem. 50:390–395.
  • Golestani, A., Rastegar, R., Shariftabrizi, A., Khaghani, S., Payabvash, S.M., Salmasi, A.H., Dehpour, A.R. and Pasalar, P. (2006). Paradoxical dose- and time-dependent regulation of superoxide dismutase and antioxidant capacity by vitamin E in rat. Clinica Chimica Acta 365:153–159.
  • Gomez, C., Terrier, N., Torregrosa, L., Vialet, S., Fournier-Level, A., Verries, C., Souquet, J.M., Mazauric, J.P., Klein, M. and Cheynier, V. (2009). Grapevine MATE-type proteins act as vacuolar H+-dependent acylated anthocyanin transporters. J. Plant Physiol. 150:402–415.
  • Gomez-Galera, S., Rojas, E., Sudhakar, D., Zhu, C., Pelacho, A.M., Capell, T. and Christou, P. (2010). Critical evaluation of strategies for mineral fortification of staple food crops. Transgenic Res. 19:165–180.
  • Graf, E. and Eaton, J.W. (1990). Antioxidant functions of phytic acid. Free Radical Bio. Med. 8:61–69.
  • Gregorio, G.B. (2002). Progress in breeding for trace minerals in staple crops. Symposium: Plant breeding: A new tool for fighting micronutrient malnutrition. Am. Soc. Nutr. Sci. 132:500S–502S.
  • Grotewold, E., Chamberlin, M., Snook, M., Siame, B., Butler, L., Swenson, J., Maddock, S., Clair, G. and Bowen, B. (1998). Engineering secondary metabolism in maize cells by ectopic expression of transcription factors. Plant Cell. 10:721–740.
  • Grotewold, E., Sainz, M.B., Tagliani, L., Hernandez, M., Bowen, B. and Chandler, V.L. (2000). Identification of the residues in the Myb domain of maize C1 that specify the interaction with the bHLH cofactor R. PNAS. U S A. 97:13579–13584.
  • Haleem, M.A., Barton, K.L., Borges, G., Crozier, A. and Anderson, A.S. (2008). Increasing antioxidant intake from fruits and vegetables: Practical strategies for the Scottish population. J. Hum. Nutr. Diet. 21:539–546.
  • Hänsch, R. and Mendel, R.R. (2009). Physiological functions of mineral micronutrients (Cu, Zn, Mn, Fe, Ni, Mo, B, Cl). Curr. Opin. Plant. Biol. 12:259–266.
  • Harjes, C., Rocheford, T.R., Bai, L., Brutnell, T.P., Kandianis, C.B., Sowinski, S.G., Stapleton, A.E., Vallabhaneni, R., Williams, M., Wurtzel, E.T., Yan, J. and Buckler, E.S. (2008). Natural genetic variation in lycopene epsilon cyclase tapped for maize biofortification. Science. 319:330–333.
  • Hawrylak-Nowak, B. (2008). Enhanced selenium content in sweet basil (Ocimum Basilicum L.) by foliar fertilization. Veg. Crops. Res. Bull. 69:63–72.
  • Hichri, I., Barrieu, F., Bogs, J., Kappel, C., Delrot, S. and Lauvergeat, V. (2011). Recent advances in the transcriptional regulation of the flavonoid biosynthetic pathway. J. Exp. Bot. . 62:2465–2483.
  • Hotz, C. and Mcclafferty, B. (2007). From harvest to health: Challenges for developing biofortified staple foods and determining their impact on micronutrient status. Food Nutr. Bull. 28:S271–S279.
  • Huang, S., Adams, W.R., Zhou, Q., Malloy, K.P., Voyles, D.A. and Jan, J. (2004). Improving nutritional quality of maize proteins by expressing sense and antisense zein genes. Agr. Food Chem. 52:1958–1964.
  • Ishikawa, T., Dowdle J. and Smirnoff, N. (2006). Progress in manipulating ascorbic acid biosynthesis and accumulation in plants. Physiol. Plantarum. 126:343–355.
  • Kim, H.J., Fonseca, J.M., Choi, J.H., Kubota, C. and Kwon, D.Y. (2008). Salt in irrigation water affects the nutritional and visual properties of romaine lettuce (Lactuca sativa L.). J. Agr. Food Chem. 56:3772–3776.
  • Kim, M.K., Ahn, S.H. and Lee-Kim, Y.C. (2001). Relationship of serum a-tocopherol, carotenoids and retinol with the risk of breast cancer. Nutr. Res. 21:797–809.
  • Kitts, D.D., Yuan, Y.V., Wijewickreme, A.N. and Thompson, L.U. (1999). Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Mol Cell Biochem. 202:91–100.
  • Kljak, K., Kiš, G. and Grbeša, D. (2009). In vitro digestibility of phenolics in grain of maize hybrids. Ital. J. Anim. Sci. 8:166–168.
  • Koeppe, D.E., Southwick, L.M. and Bitell, J.E. (1976). The relationship of tissue chlorogenic acid concentrations and leaching of phenolics from sunflowers grown under varying phosphate nutrient conditions. Can. J. Bot. 54:593–599.
  • Kopsell, D.A., Kopsell, D.E. and Celentano, J. (2007). Carotenoid pigments in kale are influenced by nitrogen concentration and form. J. Sci. Food Agr. 87:900–907.
  • Kurilich, A.C. and Juvik, J.A. (1999). Quantification of carotenoid and tocopherol antioxidants in Zea mays. J. Agr. Food Chem. 47:1948–1955.
  • Laight, D.W., Desai, K.M., Gopaul, N.K., Anggard, E.E. and Carrier, M.J. (1999). F-2-isoprostane evidence of oxidant stress in the insulin resistant, obese Zucker rat: Effects of vitamin E. Eur. J. Pharmacol. 377:89–92.
  • Lal, R. (2009). Soil degradation as a reason for inadequate human nutrition. Food Sec. 1:45–57.
  • Leenhardt, F., Levrat-Verny, M.A., Chanliaud, E. and Remesy, C. (2005). Moderate decrease of pH by sourdough fermentation is sufficient to reduce phytate content of whole wheat flour through endogenous phytase activity. J. Agr. Food Chem. 53:98–102.
  • Lesser, C. and Treutter, D. (2005). Effects of nitrogen supply on growth, contents of phenolic compounds and pathogen (scab) resistance of apple trees. Physiol. Plantarum. 123:49–56.
  • Li, F., Vallabhaneni, R., Yu, J., Rocheford, T. and Wurtzel, E.T. (2008). The maize phytoene synthase gene family: Overlapping roles for carotenogenesis in endosperm, photomorphogenesis, and thermal stress tolerance. Plant Physiol. 147:1334–1346.
  • Li, H.F., Lombi, E., Stroud, J.L., Mcgrath, S.P. and Zhao, F.J. (2010). Selenium speciation in soil and rice: Influence of water management and Se fertilization. J. Agr. Food Chem. 58:11837–11843.
  • Liu, R.H. (2007). Whole grain phytochemicals and health. J. Cereal Sci. 46:207–219.
  • Liu, S., Manson, J.E., Stampfer, M.J., Hu, F.B., Giovannucci, E., Colditz, G.A., Hennekens, C.H. and Willett, W.C. (2000). A prospective study of whole grain intake and risk of type 2 diabetes mellitus in US women. Am. J. Public Health. 90:1409–1415.
  • Liu, S., Stampfer, M.J., Hu, F.B., Giovanucci, E., Rimm, E., Manson, J.E., Hennekens, C.H. and Willett, W.C. (1999). Whole grain consumption and risk of coronary heart disease: Results from the Nurses’ Health study. Am. J. Clin. Nutr. 70:412–419.
  • Liyana-Pathirana, C.M. and Shahidi, F. (2005). Antioxidant activity of commercial soft and hard wheat (Triticum aestivum L.) as affected by gastric pH conditions. J. Agr. Food Chem. 53:2433–2440.
  • Lonnerdal, B., Bryant, A., Liu, X. and Theil, E.C. (2006). Iron absorption from soybean ferritin in nonanemic women. Am. J. Clin. Nutr. 83:103–107.
  • Lopez, H.W., Duclos, V., Coudray, C., Krespine, V., Feillet-Coudray, C., Messager, A., Demigne, C. and Remesy, C. (2003). Making bread with sourdough improves mineral bioavailability from reconstituted whole wheat flour in rats. Nutrition. 19:524–530.
  • Lopez-Martinez, L.X., Oliart-Ros, R.M., Valerio-Alfaro, G., Lee, C., Parkin, K.L. and Garcia, H.S. (2008). Antioxidant activity, phenolic compounds and anthocyanins content of eighteen strains of Mexican maize. LWT. Food Sci. Technol. 42:1187–1192.
  • Mafra, A.G. F. D. (2005). Zinc and cancer: A review. Revista saúde 1:144–156.
  • Marks, M.D., Lindell, J.S. and Larkins, B.A. (1985). Quantitative analysis of the accumulation of zein mRNA during maize endosperm development. J. Biol. Chem. 260:16445–16450.
  • Martin, A., Wu, D.Y., Baur, W., Meydani, S.N., Blumberg, J.B. and Meydani, M. (1996). Effect of vitamin E on human aortic endothelial cell responses to oxidative injury. Free Radical Bio. Med. 21:505–511.
  • Martin-Ortiz, D., Hernndez-Apaolaza, L. and Grate, A. (2009). Efficiency of a NPK fertilizer with adhered zinc lignosulfonate as a zinc source for maize (Zea mays L.). J. Agr. Food Chem. 57:9071–9078.
  • Marzabal, P., Busk, P.K., Ludevid, M.D. and Torrent, M. (1998). The bifactorial endosperm box of g-zein gene: Characterisation and function of the Pb3 and GZM cis-acting elements. Plant J. 16:41–52.
  • Menkir, A., Liu, W., White, W.S., Maziya-Dixon, B. and Rocheford, T. (2008). Carotenoid diversity in tropical-adapted yellow maize inbred lines. Food Chem. 109:521–529.
  • Messias, R.S., Galli, V., Silva, S.D. A., Schirmer, M.A. and Pillon, C.N. (2010). Metodologias de extração e avaliação semiquantitativa da expressão de genes de metabolismo secundário do milho (Zea mays L.). Boletim de Pesquisa e Desenvolvimento. . 117:1–26.
  • Misra, A., Rastogi, K., Shashank, R. and Joshi, J. (2009). Whole grains and health: Perspective for Asian Indians. JAPI. 57:155–162.
  • Mitchell, G.V., Grundel, E. and Jenkins, M.Y. (1996). Bioavailability for rats of vitamin E from fortified breakfast cereals. J. Food Sci. 61:1257–1260.
  • Moreno, F.S., Toledo, L.P., De Conti, A., Heidor, R., Jordão, J.R., Vannucchi, H., Cardozo, M.T. and Ong, T.P. (2007). Lutein presents suppressing but not blocking chemopreventive activity during diethylnitrosamine-induced hepatocarcinogenesis and this involves inhibition of DNA damage. Chem. Biol. Interact. 168:221–228.
  • Mrcophth, E.L., Nolan, J.M., O’donovan, O., Bhosale, P., Bernstein, P.S. and Beatty, S. (2008). Transport and retinal capture of lutein and zeaxanthin with reference to age-related macular degeneration. Surv. Ophthalmol. 53:68–81.
  • Myhrstad, M.C. W., Carlsen, H., Nordstrom, O., Blomhoff, R. and Moskaug, J.O. (2002). Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radical Biol. Med. 32:386–393.
  • Nagah, A.M. and Seal, C.J. (2005). In vitro procedure to predict apparent antioxidant release from wholegrain foods measured using three different analytical methods. J. Sci. Food Agr. 85:1177–1185.
  • Naqvi, S., Zhu, C., Farre, G., Ramessar, K., Bassie, L., Breitenbach, J., Conesa, D.P., Ros, G., Sandmann, G., Capell, T. and Christou, P. (2009). Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways. PNAS. 106:7762–7767.
  • Newell-Mcgloughlin, M. (2008). Nutritionally improved agricultural crops. Plant Physiol. 147:939–953.
  • Niemeyer, H.B. and Metzler, M. (2001). Differences in the antioxidant activity of plant and mammalian lignans. J. Food Eng. 56:255–356.
  • Nørbæk, R., Aaboer, D.B. F., Bleeg, I.S., Christensen, B.T., Kondo, T. and Brandt, K. (2003). Flavone C glycoside, phenolic acid, and nitrogen contents in leaves of barley subject to organic fertilization treatments. J. Agr. Food Chem. 51:809–813.
  • Ortiz-Monasterio, J.I., Palacios-Rojas, N., Meng, E., Pixley, K., Trethowan, R. and Peña, R.J. (2007). Enhancing the mineral and vitamin content of wheat and maize through plant breeding. J. Cereal Sci. 46:293–307.
  • Palaisa, K.A., Morgante, M., Williams, M. and Rafalski, A. (2003). Contrasting effects of selection on sequence diversity and linkage disequilibrium at two phytoene synthase loci. The Plant Cell. 15:1795–1806.
  • Palmgren, M.G., Clemens, S., Williams, L.E., Kramer, U., Borg, S., Schjorriong, J.K. and Sanders, D. (2008). Zinc biofortification of cereals: Problems and solutions. Trends Plant Sci. 13:464–473.
  • Panfili, G., Fratianni, A. and Irano, M. (2004). Improved normal-phase high-performance liquid chromatography procedure for the determination of carotenoids in cereals. Public Health Nutr. 52:6373–6377.
  • Park, S., Elless, M.P., Park, J., Jenkins, A., Lim, W, Chambers, E. and Hirschi, K.D. (2009). Sensory analysis of calcium-biofortified lettuce. Plant Biotechnol. J. 7:106–117.
  • Park, S., Tae, S., Kang, C,.H. Kim, J.H., Kim, S., Smith, R., Pike, L.M. and Hirschi, K.D. (2005). Genetic manipulation for enhancing calcium content in potato tuber. J. Agr. Food Chem. 53:5598–5603.
  • Pedreschi, R. and Cisneros-Zevallos, L. (2007). Phenolic profiles of Andean purple corn (Zea mays L.). Food Chem. 100:956–963.
  • Peel, G.J., Modolo, L.V., Pang, Y. and Dixon, R.A. (2009). The LAP1MYB transcription factor orchestrates anthocyanidin biosynthesis and glycosylation in Medicago. Plant J. 59:136–149.
  • Pellegrini, N., Serafini, M., Salvatore, S., Del Rio, D., Bianchi, M. and Brighenti, F. (2006). Total antioxidant capacity of spices, dried fruits, nuts, pulses, cereals and sweets consumed in Italy assessed by three different in vitro assays. Mol. Nutr. Food Res. 50:1030–1038.
  • Perez-Jimenez, J. and Saura-Calixto, F. (2005). Literature data may underestimate the actual antioxidant capacity of cereals. J. Agr. Food Chem. 53:5036–5040.
  • Pool-Zobel, B.L., Adlercreutz, H., Glei, M., Liegibe, U.M., Sittlingon, J., Rowland, I., Wähälä, K. and Rechkemmer, G. (2000). Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells. Carcinogenesis. 21:1247–1252.
  • Radi, M., Mahrouz, M., Jaouad, A. and Amiot, M.J. (2003). Influence of mineral fertilization (NPK) on the quality of apricot fruit (cv. Canino). The effect of the mode of nitrogen supply. Agronomie. 23:737–745.
  • Ramesh, S.A., Choimes, S. and Schachtman, D.P. (2004). Over-expression of an Arabidopsis zinc transporter in Hordeum vulgare increases short-term zinc uptake after zinc deprivation and seed zinc content. Plant Mol. Biol. 54:373–385.
  • Randhir, R., Kwon, Y. and Shetty, K. (2007). Effect of thermal processing on phenolics, antioxidant activity and health-relevant functionality of select grain sprouts and seedlings. Innov. Food Sci. Emerg. 9:355–364.
  • Raut, N., Sitaula, B.K. and Bajracharya, R.M. (2010). Agricultural intensification: Linking with livelihood improvement and environmental degradation in mid-hills of Nepal. J. Agr. Envir. 11:83–94.
  • Reeves, P.G., Gregoire, B.R., Garvin, D.F., Hareland, G.A., Lindlauf, J.E., Johnson, L.K. and Finley, J.W. (2007). Determination of selenium bioavailability from wheat mill fractions in rats by using the slope-ratio assay and a modified Torula yeast-based diet. J. Agr. Food Chem. 55:516–522.
  • Relea, P., Revilla, M., Ripoll, E., Arribas, I., Villa, L.F. and Rico, H. (1995). Zinc, biochemical markers of nutrition, and type I osteoporosis. Age Ageing. 24:303–307.
  • Rhee, Y., Sekhon, R.S., Chopra, S. and Kaeppler, S. (2010). Tissue culture-induced novel epialleles of a Myb transcription factor encoded by pericarp color1 in maize. Genetics. 186:843–855.
  • Rice-Evans, C.A., Miller, N.J. and Paganga, G. (1997). Antioxidant properties of phenolic compounds. Trends Plant Sci. 2:152–159.
  • Rimbach, G. and Pallauf, J. (1998). Phytic acid inhibits free radical formation in vitro but does not affect liver oxidant or antioxidant status in growing rats. J. Nutr. 128:1950–1955.
  • Santocono, M., Zurria, M., Berrettini, M., Fedeli, D. and Falcioni, G. (2006). Influence of astaxanthin, zeaxanthin and lutein on DNA damage and repair in UVA-irradiated cells. J. Photoch. Photobio. B. 85:205–215.
  • Sasaki, T. and Burr, B. (2000). International rice genome sequencing project: The effort to completely sequence the rice genome. Cur. Opin. Plant Biol. 3:138–142.
  • Saxon, M.E., Davis, M.A., Pritchard, S.G., Runion, G.B., Prior, S.A., Stelzer, H.E., Rogers, H.H. and Dute, R.R. (2004). Influence of elevated CO2, nitrogen, and Pinus elliottii genotypes on performance of the redheaded pine sawfly Neodiprion lecontei. Can. J. Forest Res. 34:1007–1017.
  • Scalbert, A., Johnson, I.T. and Saltmarsh, M. (2005). Polyphenols: Antioxidants and beyond. Am. J. Clin. Nutr. 81:215S–217S.
  • Scalbert, A. and Williamson, G. (2000). Dietary intake and bioavailability of polyphenols. J. Nutr. 130:2073–2085.
  • Schnable, P.S., Ware, D., Fulton, R.S., Stein, J.C., Wei, F.S. et al. (2009). The B73 maize genome: Complexity, diversity, and dynamics. Science. 326:1112–1115.
  • Serpen, A., Capuano, E., Fogliano, V. and Gokmen, V. (2007). A new procedure to measure the antioxidant activity of insoluble food components. J. Agr. Food Chem. 55:7676–7681.
  • Sharma, A. and Chauhan, R.S. (2008). Identification of candidate gene-based markers (SNPs and SSRs) in the zinc and iron transporter sequences of maize (Zea mays L.). Curr. Sci. 95:1051–1059.
  • Shkolnik, M.Y. (1984). Trace Elements in Plants. Elsevier, New York.
  • Simic, D., Sudara, R., Ledencana, T., Jambrovica, A., Zdunica, Z., Brkica, I. and Kovacevicb, V. (2009). Genetic variation of bioavailable iron and zinc in grain of a maize population. J. Cereal Sci. 50:392–397.
  • Slavin, J. (2003). Why whole grains are protective: Biological mechanisms. Proc. Nutr. Soc. 62:129–134.
  • Sommerburg, O., Keunenc, J.E. E., Birdd, A.C. and Kuijka, F.J. G. M. (1998). Fruits and vegetables that are sources for lutein and zeaxanthin: The macular pigment in human eyes. Brit. J. Ophthalmol. 82:907–910.
  • Sors, T.G., Ellis, D.R. and Salt, D.E. (2005). Selenium uptake, translocation, assimilation and metabolic fate in plants. Photosynth. Res. 86:373–389.
  • Sosulski, F., Krygier, K. and Hogge, L. (1982). Free, esterified, and insoluble bound phenolic acids. 3. Composition of phenolic acids in cereal and potato flours. J. Agr. Food Chem. 30:337–340.
  • Stangoulis, J.C. R., Huynh, B.L., Welch, R.M., Choi, E.Y. and Graham, R.D. (2007). Quantitative trait loci for phytate in rice grain and their relationship with grain micronutrient content. Euphytica. 154:289–294.
  • Thompson, L.U., Robb, P., Serraino, M. and Cheung, F. (1991). Mammalian lignan production from various foods. Nutr. Cancer. 16:43–52.
  • Traber, M.G. (2007). Vitamin E regulatory mechanisms. Annu. Rev. Nutr. 27:347–362.
  • Treutter, D. (2010). Managing phenol contents in crop plants by phytochemical farming and breeding—visions and constraints. Int. J. Mol. Sci. 11:807–857.
  • Uauy, C., Distelfeld, A., Fahima, T., Blechl, A. and Dubcovsky, J. (2006). A NAC gene regulating senescence improves grain protein, zinc, and iron content in wheat. Science. 314:1298–1301.
  • Urbano, G., López-Jurado, M., Aranda, P., Vidal-Valverde, C., Tenorio, E. and Porres, J. (2000). The role of phytic acid in legumes: Antinutrient or beneficial function? J. Physiol. Biochem. 56:283–294.
  • Vallabhaneni, R., Gallagher, C.E., Licciardello, N., Cuttriss, A.J., Quinlan, R.F. and Wurtzel, E.T. (2009). Metabolite sorting of a germplasm collection reveals the Hydroxylase3 locus as a new target for maize provitamin A biofortification. Plant Physiol. 51:1635–1645.
  • Vallabhaneni, R. and Wurtzel, E.T. (2009). Timing and biosynthetic potential for carotenoid accumulation in genetically diverse germplasm of maize. Plant Physiol. 150:562–572.
  • Vallejo, F., Viguera, C.G. and Tomás-Barberán, F.A. (2003). Changes in broccoli (Brassica oleracea L. Var. italica) health-promoting compounds with inflorescence development. J. Agr. Food Chem. 51:3776–3782.
  • Yan, J., Yang, X., Bai, L., Kandianis, C.B., Brutnell, T., Buckler, E.S., Harjes, C.E., Fu, Z., Li, J., Mitchell, S., Fernandez, M.G. S., Zaharieva, M., Palacios, N., Warburton, M. and Rocheford, T. (2008). HYDB1 and its interaction with LCYE influence β-carotene synthesis and improve provitamin A content in maize. Maize Genet. Conf. Abstr. 50:T9.
  • Yu, O., Shi, J., Hession, A.O., Maxwell, C.A., McGonigle, B. and Odell, J.T. (2003). Metabolic engineering to increase isoflavone biosynthesis in soybean seed. Phytochemistry. 63:753–763.
  • Yuri, A., Schmitt, E., Feucht, W. and Treutter, D. (1990). Metabolism of Prunus tissues affected by Ca2+-deficiency and addition of prunin. J. Plant Physiol. 135:692–697
  • Waters, B.M. and Sankaran, R.P. (2010). Moving micronutrients from the soil to the seeds: Genes and physiological processes from a biofortification perspective. Plant Sci. 180:562–574.
  • Welch, R.M. and Graham, R.D. (2004). Breeding for micronutrients in staple food crops from a human nutrition perspective. J. Exp. Bot. 55:353–364.
  • WHO—World Health Organization. (2000). Nutrition for health and development. In: Turning the Tide of Malnutrition: Responding to the Challenge of the 21st Century. World Health Organization, Geneva, Switzerland.
  • Witzell, J. and Shevtsova, A. (2004). Nitrogen-induced changes in phenolics of Vaccinium myrtillus–Implications for interaction with a parasitic fungus. J. Chem. Ecol. 30:1937–1956.
  • Wu, Y., Holding, D.R. and Messing, J. (2010). γ-Zeins are essential for endosperm modification in quality protein maize. PNAS. 107:12810–12815.
  • Zhang, J., Wu, L. and Wang, M. (2008). Can iron and zinc in rice grains (Oryza sativa L.) be biofortified with nitrogen fertilisation under pot conditions? J. Sci. Food Agr. 88:1172–1177.
  • Zhao, J., Pang, Y. and Dixon, R.A. (2010). The mysteries of proanthocyanidin transport and polymerization. J. Plant Physiol. 153:437–443.
  • Zhao, Z.Q., Zhu, Y.G., Li, H.Y., Smith, S.E. and Smith, F.A. (2004). Effects of forms and rates of potassium fertilizers on cadmium uptake by two cultivars of spring wheat (Triticum aestivum, L.). Environ. Int. 29:973–978.
  • Zhu, C., Naqvi, S., Gomez-Galera, S., Pelacho, A.M., Capell, T. and Christou, P. (2007). Transgenic strategies for the nutritional enhancement of plants. Trends Plant Sci. 12:548–555.
  • Zornoza, P. and Esteban, R.M. (1984). Flavonoids content of tomato plants for the study of the nutritional status. Plant Soil. 82:269–271.

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