Isolation and Characterization of Peptides with Antihypertensive Activity in Foodstuffs

REFERENCES

• Abubakar, A., Saito, T., Kitazawa, H., Kawai, Y. and Itoh, T. (1998). Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J. Dairy Sci. 81:3131–3138.
   PubMed Web of Science ®Google Scholar
• Alves, M.F., Araujo, M.C., Juliano, M.A., Oliveira, E.M., Krieger J.E., Casarini, D.E., Juliano, L. and Carmona, A.K. (2005). A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity. Braz. J. Med. Biol. Res. 38:861–868.
   PubMed Web of Science ®Google Scholar
• Arihara, K., Nakashima, Y., Mukai, T., Ishikawa, S. and Itoh, M. (2001). Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle proteins. Meat Sci. 57:319–324.
   PubMed Web of Science ®Google Scholar
• Atkinson, A.B. and Robertson, J.I. (1979). Captopril in the treatment of clinical hypertension and cardiac failure. Lancet. 2:836–839.
   PubMed Web of Science ®Google Scholar
• Butikofer, U., Meyer, J., Sieber, R. and Wechsler, D. (2007). Quantification of the angiotensin-converting enzyme-inhibiting tripeptides Val-Pro-Pro and Ile-Pro-Pro in hard, semi-hard and soft cheeses. Int. Dairy J. 17:968–975.
   Web of Science ®Google Scholar
• Byun, H.G. and Kim, S.K. (2001). Purification and characterization of angiotensin I converting enzyme (ACE) inhibitory peptides from Alaska pollack (Theragra chalcogramma) skin. Process Biochem. 36:1155–1162.
   Web of Science ®Google Scholar
• Chen, J.R., Okada, T., Muramoto, K., Suetsuna, K. and Yang, S.C. (2002). Identification of angiotensin I-converting enzyme inhibitory peptides derived from the peptic digest of soybean protein. J. Food Biochem. 26:543–554.
   Web of Science ®Google Scholar
• Chen, Z.Y., Peng, C., Jiao, R., Wong, Y.M., Yang, N. and Huang, Y. (2009). Anti-hypertensive nutraceuticals and functional foods. J. Agric. Food Chem. 57:4485–4499.
   PubMed Web of Science ®Google Scholar
• Cheng, F.Y., Wan, T.C., Liu, Y.T., Chen, C.M., Lin, L.C. and Sakata, R. (2009). Determination of angiotensin-I converting enzyme inhibitory peptides in chicken leg bone protein hydrolysate with alcalase. Anim. Sci. J. 80:91–97.
   PubMed Web of Science ®Google Scholar
• Chiang, W.D., Tsou, M.J., Tsai, Z.Y. and Tsai, T.C. (2006). Angiotensin I-converting enzyme inhibitor derived from soy protein hydrolysate and produced by using membrane reactor. Food Chem. 98:725–732.
   Web of Science ®Google Scholar
• Chobert, J.M., El-Zahar, K., Sitohy, M., Dalgalarrondo, M., Metro, F., Choiset, Y. and Haertle, T. (2005). Angiotensin I-converting-enzyme (ACE)-inhibitory activity of tryptic peptides of ovine beta-lactoglobulin and of milk yoghurts obtained by using different starters. Lait. 85:141–152.
   Google Scholar
• Chockalingam, A. (2008). World Hypertension Day and global awareness. Can. J. Cardiol. 24:441–444.
   PubMed Web of Science ®Google Scholar
• Contreras, Mdel.M., Carron, R., Montero, M.J., Ramos, M. and Recio, I. (2009). Novel casein-derived peptides with antihypertensive activity. Int. Dairy J. 19:566–573.
   Web of Science ®Google Scholar
• Contreras, Mdel.M., López-Expósito, I., Hernández-Ledesma, B., Ramos, M. and Recio, I. (2008). Application of mass spectrometry to the characterization and quantification of food-derived bioactive peptides. J. AOAC Int. 91:981–994.
   PubMed Web of Science ®Google Scholar
• Curtis, J.M., Dennis, D., Waddell, D.S., MacGillivray, T. and Ewart, H.S. (2002). Determination of angiotensin-converting enzyme inhibitory peptide Leu-Lys-Pro-Asn-Met (LKPNM) in bonito muscle hydrolysates by LC-MS/MS. J. Agric. Food Chem. 50:3919–3925.
   PubMed Web of Science ®Google Scholar
• Cushman, D.W. and Cheung, H.S. (1971). Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20:1637–1648.
   PubMed Web of Science ®Google Scholar
• Cushman, D.W. and Ondetti, M.A. (1991). History of the design of captopril and related inhibitors of angiotensin converting enzyme. Hypertension. 17:589–592.
   PubMed Web of Science ®Google Scholar
• De Simone, C., Picariello, G., Mamone, G., Stiuso, P., Dicitore, A., Vanacore, D., Chianese, L., Addeo, F. and Ferranti, P. (2009). Characterisation and cytomodulatory properties of peptides from Mozzarella di Bufala Campana cheese whey. J. Pept. Sci. 15:251–258.
   PubMed Web of Science ®Google Scholar
• Donkor, O.N., Henriksson, A., Singh, T.K., Vasiljevic, T. and Shah, N.P. (2007). ACE-inhibitory activity of probiotic yoghurt. Int. Dairy J. 17:1321–1331.
   Web of Science ®Google Scholar
• Enari, H., Takahashi, Y., Kawarasaki, M., Tada, M. and Tatsuta, K. (2008). Identification of angiotensin I-converting enzyme inhibitory peptides derived from salmon muscle and their antihypertensive effect. Fisheries Sci. 74:911–920.
   Web of Science ®Google Scholar
• Escudero, E., Sentandreu, M.A., Arihara, K. and Toldra, F. (2010). Angiotensin I-converting enzyme inhibitory peptides generated from in vitro gastrointestinal digestion of pork meat. J. Agric. Food Chem. 58:2895–2901.
   PubMed Web of Science ®Google Scholar
• Ezzati, M., Hoorn, S.V., Rodgers, A., Lopez, A.D., Mathers, C.D. and Murray, C.J. (2003). Comparative risk assessment collaborating group, estimates of global and regional potential health gains from reducing multiple major risk factors. The Lancet. 362:271–280.
   PubMed Web of Science ®Google Scholar
• Ferreira, S.H., Bartelt, D.C. and Greene, L.J. (1970). Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom. Biochemistry. 9:2583–2593.
   PubMed Web of Science ®Google Scholar
• FitzGerald, R.J., Murray, B.A. and Walsh, D.J. (2004). Hypotensive peptides from milk proteins. J. Nutr. 134:980S–988S.
   PubMed Web of Science ®Google Scholar
• Fujii, M., Matsumura, N., Mito, K., Shimizu, T., Kuwahara, M., Sugano, S. and Karaki, H. (1993). Antihypertensive effects of peptides in autolysate of bonito bowels on spontaneously hypertensive rats. Biosci. Biotech. Biochem. 57:2186–2188.
   PubMed Web of Science ®Google Scholar
• Fujita, H. and Yoshikawa, M. (1999). LKPNM: A prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology. 44:123–127.
   PubMed Web of Science ®Google Scholar
• Fujita, H., Yokoyama, K. and Yoshikawa, M. (2000). Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J. Food Sci. 65:564–569.
   Web of Science ®Google Scholar
• Geerlings, A., Villar, I.C., Zarco, F.H., Sanchez, M., Vera, R., Gómez, A.Z., Boza, J. and Duarte, J. (2006). Identification and characterization of novel angiotensin-converting enzyme inhibitors obtained from goat milk. J. Dairy Sci. 89:3326–3335.
   PubMed Web of Science ®Google Scholar
• Gilani, G.S., Xiao, C. and Lee, N. (2008). Need for accurate and standardized determination of amino acids and bioactive peptides for evaluating protein quality and potential health effects of foods and dietary supplements. J. AOAC Int. 91:894–900.
   PubMed Web of Science ®Google Scholar
• Gómez-Ruiz, J.A., Ramos, M. and Recio, I. (2002). Angiotensin-converting enzyme-inhibitory peptides in Manchego cheeses manufactured with different starter cultures. Int. Dairy J. 12:697–706.
   Web of Science ®Google Scholar
• Gómez-Ruiz, J.A., Ramos, M. and Recio, I. (2004). Identification and formation of angiotensin-converting enzyme-inhibitory peptides in Manchego cheese by high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A. 1054:269–277.
   PubMed Web of Science ®Google Scholar
• Gómez-Ruiz, J.A., Ramos, M. and Recio, I. (2007). Identification of novel angiotensin-converting enzyme-inhibitory peptides from ovine milk proteins by CE-MS and chromatographic techniques. Electrophoresis. 28:4202–4211.
   PubMed Web of Science ®Google Scholar
• Gómez-Ruiz, J.A., Taborda, G., Amigo, L., Recio, I. and Ramos, M. (2006). Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry. Eur. Food Res. Technol. 223:595–601.
   Web of Science ®Google Scholar
• Gouda, K.G. M., Gowda, L.R., Rao, A.G. A. and Prakash, V. (2006). Angiotensin I-converting enzyme inhibitory peptide derived from glycinin, the 11S globulin of soybean (Glycine max). J. Agric. Food Chem. 54:4568–4457.
   PubMed Web of Science ®Google Scholar
• Haileselassie, S.S., Lee, B.H. and Gibbs, B.F. (1999). Purification and identification of potentially bioactive peptides from enzyme-modified cheese. J. Dairy Sci. 82:1612–1617.
   PubMed Web of Science ®Google Scholar
• Hatanaka, A., Miyahara, H., Suzuki, K.I. and Sato, S. (2009). Isolation and identification of antihypertensive peptides from Antarctic krill tail meat hydrolysate. J. Food Sci. 74:116–120.
   PubMed Web of Science ®Google Scholar
• Hernández-Ledesma, B., Amigo, L., Ramos, M. and Recio, I. (2004). Application of high-performance liquid chromatography-tandem mass spectrometry to the identification of biologically active peptides produced by milk fermentation and simulated gastrointestinal digestion. J. Chromatogr. A. 1049:107–114.
   PubMed Web of Science ®Google Scholar
• Hernández-Ledesma, B., Recio, I. and Amigo, L. (2008). Beta-lactoglobulin as source of bioactive peptides. Amino Acids. 35:257–265.
   PubMed Web of Science ®Google Scholar
• Herraiz, T. (1997). Sample preparation and reversed phase-high performance liquid chromatography analysis of food-derived peptides. Anal. Chim. Acta. 352:119–139.
   Web of Science ®Google Scholar
• Holmquist, B., Bünning, P. and Riordan, J.F. (1979). A continuous spectrophotometric assay for angiotensin converting enzyme. Anal. Biochem. 95:540–548.
   PubMed Web of Science ®Google Scholar
• Hyoung, LeeD., Ho, KimJ., Sik, ParkJ., Jun, ChoiY. and Soo, LeeJ. (2004). Isolation and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from the edible mushroom Tricholoma giganteum. Peptides. 25:621–627.
   PubMed Web of Science ®Google Scholar
• Inoue, K., Gotou, T., Kitajima, H., Mizuno, S., Nakazawa, T. and Yamamoto, N. (2009). Release of antihypertensive peptides in miso paste during its fermentation, by the addition of casein. J. Biosci. Bioeng. 108:111–115.
   PubMed Web of Science ®Google Scholar
• Iwaniak, A. and Minkiewicz, P. (2008). Biologically active peptides derived from proteins—A review. Pol. J. Food Nutr. Sci. 58:289–294.
   Google Scholar
• Jang, A. and Lee, M. (2005). Purification and identification of angiotensin converting enzyme inhibitory peptides from beef hydrolysates. Meat Sci. 69:653–661.
   PubMed Web of Science ®Google Scholar
• Je, J.Y., Park, P.J., Byun, H.G., Jung, W.K. and Kim, S.K. (2005b). Angiotensin I converting enzyme (ACE) inhibitory peptide derived from the sauce of fermented blue mussel, Mytilus edulis. Bioresour. Technol. 96:1624–1629.
   PubMed Web of Science ®Google Scholar
• Je, J.Y., Park, J.Y., Jung, W.K., Park, P.J. and Kim, S.K. (2005a). Isolation of angiotensin I converting enzyme (ACE) inhibitor from fermented oyster sauce, Crassostrea gigas. Food Chem. 90:809–814.
   Web of Science ®Google Scholar
• Jia, J.Q., Ma, H.L., Zhao, W.R., Wang, Z.B., Tian, W.M., Luo, L. and He, R.H. (2010). The use of ultrasound for enzymatic preparation of ACE-inhibitory peptides from wheat germ protein. Food Chem. 119:336–342.
   Web of Science ®Google Scholar
• Jiang, J.L., Chen, S.W., Ren, F.Z., Luo, Z. and Zeng, S.S. (2007). Yak milk casein as a functional ingredient: Preparation and identification of angiotensin-I-converting enzyme inhibitory peptides. J. Dairy Res. 74:18–25.
   PubMed Web of Science ®Google Scholar
• Jung, W.K., Mendis, E., Je, J.Y., Park, P.J., Son, B.W., Kim, H.C., Choi, Y.K. and Kim, S.K. (2006). Angiotensin I-converting enzyme inhibitory peptide from yellowfin sole (Limanda aspera) frame protein and its antihypertensive effect in spontaneously hypertensive rats. Food Chem. 94:26–32.
   Web of Science ®Google Scholar
• Kapel, R., Rahhou, E., Lecouturier, D., Guillochon, D. and Dhulster, P. (2006). Characterization of an antihypertensive peptide from an Alfalfa white protein hydrolysate produced by a continuous enzymatic membrane reactor. Process Biochem. 41:1961–1966.
   Web of Science ®Google Scholar
• Katayama, K., Anggraeni, H.E., Mori, T., Ahhmed, A.A., Kawahara, S., Sugiyama, M., Nakayama, T., Maruyama, M. and Mugurumat, M. (2008). Porcine skeletal muscle troponin is a good source of peptides with angiotensin-I converting enzyme inhibitory activity and anti hypertensive effects in spontaneously hypertensive rats. J. Agric. Food Chem. 56:355–360.
   PubMed Web of Science ®Google Scholar
• Katayama, K., Jamhari, MoriT., Kawahara, S., Miake, K., Kodama, Y., Sugiyama, M., Kawamura, Y., Nakayama, T., Muruyama, M. and Muguruma, M. (2007). Angiotensin-I converting enzyme inhibitory peptide derived from porcine skeletal muscle myosin and its antihypertensive activity in spontaneously hypertensive rats. J. Food Sci. 72:702–706.
   PubMed Web of Science ®Google Scholar
• Kitts, D.D. and Weiler, K. (2003). Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Curr. Pharm. Des. 9:1309–1323.
   PubMed Web of Science ®Google Scholar
• Kodera, T. and Nio, N. (2006). Identification of an angiotensin I-converting enzyme inhibitory peptides from protein hydrolysates by a soybean protease and the antihypertensive effects of hydrolysates in spontaneously hypertensive model rats. J. Food Sci. 71:C164–173.
   Web of Science ®Google Scholar
• Koo, K.C., Lee, D.H., Kim, J.H., Yu, H.E., Park, J.S. and Lee, J.S. (2006). Production and characterization of antihypertensive angiotensin I-converting enzyme inhibitor from Pholiota adiposa. J. Microbiol. Biotechnol. 16:757–763.
   Google Scholar
• Korhonen, H. and Pihlanto, A. (2003). Food-derived bioactive peptides—Opportunities for designing future foods. Curr. Pharm. Des. 9:1297–1308.
   PubMed Web of Science ®Google Scholar
• Kuba, M., Tanaka, K., Sesoko, M., Inoue, F. and Yasuda, M. (2009). Angiotensin I-converting enzyme inhibitory peptides in red-mold rice made by Monascus purpureus. Process Biochem. 44:1139–1143.
   Web of Science ®Google Scholar
• Lawes, C.M., Vander Hoorn, S. and Rodgers, A. (2008). Global burden of blood-pressure-related disease, 2001. Lancet. 371:1513–1518.
   PubMed Web of Science ®Google Scholar
• Lee, N.Y., Cheng, J.T., Enomoto, T. and Nakamura, I. (2006a). The antihypertensive activity of angiotensin-converting enzyme inhibitory peptide containing in bovine lactoferrin. Chin. J. Physiol. 49:67–73.
   PubMed Web of Science ®Google Scholar
• Lee, N.Y., Cheng, J.T., Enomoto, T. and Nakamura, I. (2006b). Antihypertensive effect of angiotensin-converting enzyme inhibitory peptide obtained from hen ovotransferrin. J. Chinese Chem. Society. 53:495–501.
   Web of Science ®Google Scholar
• Lee, N.Y., Cheng, J.T., Enomoto, T. and Nakano, Y. (2006c). One peptide derived from hen ovotransferrin as pro-drug to inhibit angiotensin converting enzyme. J. Food Drug Analysis. 14:31–35.
   Web of Science ®Google Scholar
• Lee, S.H., Qian, Z.J. and Kim, S.K. (2010). A novel angiotensin I converting enzyme inhibitory peptide from tuna frame protein hydrolysate and its antihypertensive effect in spontaneously hypertensive rats. Food Chem. 118:96–102.
   Web of Science ®Google Scholar
• Li, G.H., Le, G.W., Shi, Y.H. and Shrestha, S. (2004). Angiotensin I-converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects. Nutr. Res. 24:469–486.
   Web of Science ®Google Scholar
• Li, C.H., Matsui, T., Matsumoto, K., Yamasaki, R. and Kawasaki, T. (2002). Latent production of angiotensin I-converting enzyme inhibitors from buckwheat protein. J. Pept. Sci. 8:267–274.
   PubMed Web of Science ®Google Scholar
• Li, G.H., Qu, M.R., Wan, J.Z. and You, J.M. (2007). Antihypertensive effect of rice protein hydrolysate with in vitro angiotensin I-converting enzyme inhibitory activity in spontaneously hypertensive rats. Asia Pac. J. Clin. Nutr. 16:275–280.
   PubMed Web of Science ®Google Scholar
• Li, G.H., Wan, J.Z., Le, G.W. and Shi, Y.H. (2006). Novel angiotensin I-converting enzyme inhibitory peptides isolated from Alcalase hydrolysate of mung bean protein. J. Pept. Sci. 12:509–514.
   PubMed Web of Science ®Google Scholar
• Lopez-Fandiño, R., Otte, J. and van Camp, J. (2006). Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity. Int. Dairy J. 16:1277–1293.
   Web of Science ®Google Scholar
• Madureira, A.R., Tavares, T., Gomes, A.M. P., Pintado, M.E. and Malcata, F.X. (2010). Invited review: Physiological properties of bioactive peptides obtained from whey proteins. J. Dairy Sci. 93:437–455.
   PubMed Web of Science ®Google Scholar
• Maeno, M., Yamamoto, N. and Takano, T. (1996). Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J. Dairy Sci. 79:1316–1321.
   PubMed Web of Science ®Google Scholar
• Majumder, K. and Wu, J. (2009). Angiotensin I converting enzyme inhibitory peptides from simulated in vitro gastrointestinal digestion of cooked eggs. J. Agric. Food Chem. 57:471–477.
   PubMed Web of Science ®Google Scholar
• Mao, X.Y., Ni, J.R., Sun, W.L., Hao, P.P. and Fan, L. (2007). Value-added utilization of yak milk casein for the production of angiotensin-I-converting enzyme inhibitory peptides. Food Chem. 103:1282–1287.
   Web of Science ®Google Scholar
• Maruyama, S. and Suzuki, H. (1982). A peptide inhibitor of angiotensin-I converting enzyme in tryptic hydrolysate of casein. Agric. Biol. Chem. 46:1393–1394.
   Web of Science ®Google Scholar
• Matsui, T., Yukiyoshi, A., Doi, S., Sugimoto, H., Yamada, H. and Matsumoto, K. (2002). Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR. J. Nutr. Biochem. 13:80–86.
   PubMed Web of Science ®Google Scholar
• Matsumura, N., Fujii, M., Takeda, Y., Sugita, K. and Shimizu, T. (1993). Angiotensin I-converting enzyme inhibitory peptides derived from bonito bowels autolysate. Biosci. Biotech. Biochem. 57:695–697.
   PubMed Web of Science ®Google Scholar
• Meisel, H. (1997). Biochemical properties of regulatory peptides derived from milk proteins. Biopolymers. 43:119–128.
   PubMed Web of Science ®Google Scholar
• Meng, Q. C. and Oparil, S. (1996). Purification and assay methods for angiotensin-converting enzyme. J. Chromatogr. A. 743:105–122.
   PubMed Web of Science ®Google Scholar
• Meyer, J., Butikofer, U., Walther, B., Wechsler, D. and Sieber, R. (2009). Changes in angiotensin-converting enzyme inhibition and concentrations of the tripeptides Val-Pro-Pro and Ile-Pro-Pro during ripening of different Swiss cheese varieties. J. Dairy Sci. 92:826–836.
   PubMed Web of Science ®Google Scholar
• Miguel, M., Contreras, M.M., Recio, I. and Aleixandre, A. (2009). ACE-inhibitory and antihypertensive properties of a bovine casein hydrolysate. Food Chem. 112:211–214
   Web of Science ®Google Scholar
• Minkiewicz, P., Dziuba, J., Iwaniak, A., Dziuba, M. and Darewicz, M. (2008). BIOPEP and other programs processing bioactive peptide sequences. J. AOAC Int. 91:965–980.
   PubMed Web of Science ®Google Scholar
• Miyoshi, S., Ishikawa, H., Kaneko, T., Fukui, F., Tanaka, H. and Maruyama, S. (1991). Structures and activity of angiotensin-converting enzyme inhibitors in an alpha-zein hydrolysate. J. Agric. Biol. Chem. 55:1313–1318.
   PubMed Web of Science ®Google Scholar
• Moller, N.P., Scholz-Ahrens, K.E., Roos, N. and Schrezenmeir, J. (2008). Bioactive peptides and proteins from foods: indication for health effects. Eur. J. Nutr. 47:171–182.
   PubMed Web of Science ®Google Scholar
• Motoi, H. and Kodama, T. (2003). Isolation and characterization of angiotensin I-converting enzyme inhibitory peptides from wheat gliadin hydrolysate. Nahrung-Food. 47:354–358.
   PubMedGoogle Scholar
• Muguruma, M., Ahhmed, A.M., Katayama, K., Kawahara, S., Maruyama, M. and Nakamura, T. (2009). Identification of pro-drug type ACE inhibitory peptide sourced from porcine myosin B: Evaluation of its antihypertensive effects in vivo. Food Chem. 114:516–522.
   Web of Science ®Google Scholar
• Murakami, M., Tonouchi, H., Takahashi, R., Kitazawa, H., Kawai, Y., Negishi, H. and Saito, T. (2004). Structural analysis of a new anti-hypertensive peptide (beta-lactosin B) isolated from a commercial whey product. J. Dairy Sci. 87:1967–1974.
   PubMed Web of Science ®Google Scholar
• Murray, B.A. and FitzGerald, R.J. (2007). Angiotensin converting enzyme inhibitory peptides derived from food proteins: Biochemistry, bioactivity and production. Curr. Pharm. Des. 13:773–791.
   PubMed Web of Science ®Google Scholar
• Nakade, K., Kamishima, R., Inoue, Y., Ahhmed, A., Kawahara, S., Nakayama, T., Maruyama, M., Numata, M., Ohta, K., Aoki, T. and Muguruma, M. (2008). Identification of an antihypertensive peptide derived from chicken bone extract. Anim. Sci. J. 79:710–715.
   Web of Science ®Google Scholar
• Nakahara, T., Sano, A., Yamaguchi, H., Sugimoto, K.R. I., Chikata, H., Kinoshita, E. and Uchida, R. (2010). Antihypertensive effect of peptide-enriched soy sauce-like seasoning and identification of its angiotensin I-converting enzyme inhibitory substances. J. Agric. Food Chem. 58:821–827.
   PubMed Web of Science ®Google Scholar
• Nakamura, Y., Yamamoto, N., Sakai, K., Okubo, A., Yamazaki, S. and Takano, T. (1995). Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J. Dairy Sci. 78:777–783.
   PubMed Web of Science ®Google Scholar
• Nakano, D., Ogura, K., Miyakoshi, M., Ishii, F., Kawanishi, H., Kurumazuka, D., Kwak, C.J., Ikemura, K., Takaoka, M., Moriguchi, S., Jino, T., Kusumoto, A., Asami, S., Shibata, H., Kiso, Y. and Matsumura, Y. (2006). Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides from a sesame protein hydrolysate in spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 70:1118–1126.
   PubMed Web of Science ®Google Scholar
• Nakashima, E.M., Kudo, A., Iwaihara, Y., Tanaka, M., Matsumoto, K., Matsui, T. (2011). Application of 13C stable isotope labeling liquid chromatography-multiple reaction monitoring-tandem mass spectrometry method for determining intact absorption of bioactive dipeptides in rats. Anal. Biochem. 414:109–116.
   PubMed Web of Science ®Google Scholar
• Neville, W.A. (2004). Reversed-phase chromatography of proteins. In: Protein Purification Protocols. Methods in Molecular Biology, Vol. , 2nd ed., pp. 259–281. Cutler, P., Ed., Humana Press, Totowa, NJ.
   Google Scholar
• Nielsen, M.S., Martinussen, T., Flambard, B., Sorensen, K.I. and Otte, J. (2009). Peptide profiles and angiotensin-I-converting enzyme inhibitory activity of fermented milk products: Effect of bacterial strain, fermentation pH, and storage time. Int. Dairy J. 19:155–165.
   Web of Science ®Google Scholar
• Nogata, Y., Nagamine, T., Yanaka, M. and Ohta, H. (2009). Angiotensin I converting enzyme inhibitory peptides produced by autolysis reactions from wheat bran. J. Agric. Food Chem. 57:6618–6622.
   PubMed Web of Science ®Google Scholar
• Ono, S., Hosokawa, M., Miyashita, K. and Takahashi, K. (2003). Isolation of peptides with angiotensin I-converting enzyme inhibitory effect derived from hydrolysate of upstream chum salmon muscle. J. Food Sci. 68:1611–1614.
   Web of Science ®Google Scholar
• Otte, J., Shalaby, S.M. A., Zakora, M. and Nielsen, M.S. (2007b). Fractionation and identification of ACE-inhibitory peptides from alpha-lactalbumin and beta-casein produced by thermolysin-catalysed hydrolysis. Int. Dairy J. 17:1460–1472.
   Web of Science ®Google Scholar
• Otte, J., Shalaby, S.M., Zakora, M., Pripp, A.H. and EI-Shabrawy, S.A. (2007a). Angiotensin-converting enzyme inhibitory activity of milk protein hydrolysates: Effect of substrate, enzyme and time of hydrolysis. Int. Dairy J. 17:488–503.
   Web of Science ®Google Scholar
• Pan, D., Luo, Y.K. and Tanokura, M. (2005). Antihypertensive peptides from skimmed milk hydrolysate digested by cell-free extract of Lactobacillus helveticus JCM1004. Food Chem. 91:123–129.
   Web of Science ®Google Scholar
• Papadimitriou, C.G., Vafopoulou-Mastrojiannaki, A., Silva, S.V., Gomes, A.M., Malcata, F.X. and Alichanidis, E. (2007). Identification of peptides in traditional and probiotic sheep milk yoghurt with angiotensin I-converting enzyme (ACE)-inhibitory activity. Food Chem. 105:647–656.
   Web of Science ®Google Scholar
• Perez, M.I. and Musini, V.M. (2008). Pharmacological interventions for hypertensive emergencies: A Cochrane systematic review. J. Hum. Hypertens. 22:596–607.
   PubMed Web of Science ®Google Scholar
• Pihlanto-Leppala, A. (2000). Bioactive peptides derived from bovine whey proteins: Opioid and ACE-inhibitory peptides. Trends Food Sci. Technol. 11:347–356.
   Web of Science ®Google Scholar
• Pina, A.S. and Roque, A.C. A. (2009). Studies on the molecular recognition between bioactive peptides and angiotensin-converting enzyme. J. Mol. Recognit. 22:162–168.
   PubMed Web of Science ®Google Scholar
• Qian, Z.J., Je, J.Y. and Kim, S.K. (2007a). Antihypertensive effect of angiotensin I converting enzyme-inhibitory peptide from hydrolysates of bigeye tuna dark muscle, Thunnus obesus. J. Agric. Food Chem. 55:8398–8403.
   PubMed Web of Science ®Google Scholar
• Qian, Z.J., Jung, W.K., Lee, S.H., Byun, H.G. and Kim, S.K. (2007b). Antihypertensive effect of an angiotensin I-converting enzyme inhibitory peptide from bullfrog (Rana catesbeiana Shaw) muscle protein in spontaneously hypertensive rats. Process Biochem. 42:1443–1448.
   Web of Science ®Google Scholar
• Quiros, A., Chichon, R., Recio, I. and Lopez-Fandiño, R. (2007a). The use of high hydrostatic pressure to promote the proteolysis and release of bioactive peptides from ovalbumin. Food Chem. 104:1734–1739.
   Web of Science ®Google Scholar
• Quiros, A., Davalos, A., Lasuncion, M.A., Ramos, M. and Recio, I. (2008). Bioavailability of the antihypertensive peptide LHLPLP: Transepithelial flux of HLPLP. Int. Dairy J. 18:279–286.
   Web of Science ®Google Scholar
• Quiros, A., Hernández-Ledesma, B., Ramos, M., Amigo, L. and Recio, I. (2005). Angiotensin-converting enzyme inhibitory activity of peptides derived from caprine kefir. J. Dairy Sci. 88:3480–3487.
   PubMed Web of Science ®Google Scholar
• Quiros, A., Ramos, M., Muguerza, B., Delgado, M.A., Martin-Alvarez, P.J., Aleixandre, A. and Recio, I. (2006). Determination of the antihypertensive peptide LHLPLP in fermented milk by high-performance liquid chromatography-mass spectrometry. J. Dairy Sci. 89:4527–4535.
   PubMed Web of Science ®Google Scholar
• Quiros, A., Ramos, M., Muguerza, B., Delgado, MA., Miguel, M., Aleixandre, A. and Recio, I. (2007b). Identification of novel antihypertensive peptides in milk fermented with Enterococcus faecalis. Int. Dairy J. 17:33–41.
   Web of Science ®Google Scholar
• Rho, S.J., Lee, J.S., Chung, Y.I., Kim, Y.W. and Lee, H.G. (2009). Purification and identification of an angiotensin I-converting enzyme inhibitory peptide from fermented soybean extract. Process Biochem. 44:490–493.
   Web of Science ®Google Scholar
• Ricci, I., Artacho, R. and Olalla, M. (2010). Milk protein peptides with angiotensin I-converting enzyme inhibitory (ACEI) activity. Crit. Rev. Food Sci. Nutr. 50:390–402.
   PubMed Web of Science ®Google Scholar
• Rizzello, C.G., Cassone, A., Di Cagno, R. and Gobbetti, M. (2008). Synthesis of angiotensin I-converting enzyme (ACE)-inhibitory peptides and gamma-aminobutyric acid (GABA) during sourdough fermentation by selected lactic acid bacteria. J. Agric. Food Chem. 56:6936–6943.
   PubMed Web of Science ®Google Scholar
• Robert, M.C., Razaname, A., Mutter, M. and Juillerat, M.A. (2004). Peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765. J. Agric. Food Chem. 52:6923–6931.
   PubMed Web of Science ®Google Scholar
• Rohzabach, M.S. (1978). [Glycine-1’4C]hippurylhistidylleucine: A substrate for the radiochemical assay of angiotensin-converting enzyme. Anal. Biochem. 84:272–276.
   PubMed Web of Science ®Google Scholar
• Saiga, A., Iwai, K., Hayakawa, T., Takahata, Y., Kitamura, S., Nishimura, T. and Morimatsu, F. (2008). Angiotensin I-converting enzyme-inhibitory peptides obtained from chicken collagen hydrolysate. J. Agric. Food Chem. 56:9586–9591.
   PubMed Web of Science ®Google Scholar
• Saito, T., Nakamura, T., Kitazawa, H., Kawai, Y. and Itoh, T. (2000). Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese. J. Dairy Sci. 83:1434–1440.
   PubMed Web of Science ®Google Scholar
• Samaranayaka, A.G. P., Kitts, D.D. and Li-Chan, E.C. Y. (2010). Antioxidative and angiotensin-1-converting enzyme inhibitory potential of a pacific hake (Merluccius productus) fish protein hydrolysate subjected to simulated gastrointestinal digestion and Caco-2 cell permeation. J. Agric. Food Chem. 58:1535–1542.
   PubMed Web of Science ®Google Scholar
• Sato, M., Hosokawa, T., Yamaguchi, T., Nakano, T., Muramoto, K., Kahara, T., Funayama, K., Kobayashi, A. and Nakano, T. (2002). Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats. J. Agric. Food Chem. 50:6245–6252.
   PubMed Web of Science ®Google Scholar
• Schmieder, R.E., Hilgers, K.F., Schlaich, M.P. and Schmidt, B.M. W. (2007). Renin-angiotensin system and cardiovascular risk. Lancet. 369:1208–1219.
   PubMed Web of Science ®Google Scholar
• Schratter, P. (2004). Purification and concentration by ultrafiltration. In: Protein Purification Protocols. Methods in Molecular Biology. Vol. , 2nd ed., pp. 101–116. Cutler, P., Ed., Humana Press, Totowa, NJ.
   Google Scholar
• Schrezenmeir, J., Korhonen, H., Williams, Ch., Gill, H.S. and Shah, N. (2000). Foreword. Br. J. Nutr. 84:S1–1.
   PubMed Web of Science ®Google Scholar
• Selkirk, C. (2004). Ion-exchange chromatography. In: Protein Purification Protocols. Methods in Molecular Biology. Vol. , 2nd ed., pp. 125–131. Cutler, P., Ed., Humana Press, Totowa, NJ.
   Google Scholar
• Sewald, N. and Jakubke, H.D. (2009). Fundamental chemical and structural principles. In: Peptides: The Chemistry and Biology, pp. 13–17. Wiley-VCH Verlag GmbH & Co. KGGaA, Weinheim.
   Google Scholar
• Shin, Z.I., Yu, R., Park, S.A., Chung, D.K., Ahn, C.W., Nam, H.S.S. Kim, K.S. and Lee, H.J. (2001). His-His-Leu, an angiotensin I converting enzyme inhibitory peptide derived from Korean soybean paste, exerts antihypertensive activity in vivo. J. Agric. Food Chem. 49:3004–3009.
   PubMed Web of Science ®Google Scholar
• Sirtori, C.R., Galli, C., Anderson, J.W. and Arnoldi, A. (2009). Nutritional and nutraceutical approaches to dyslipidemia and atherosclerosis prevention: Focus on dietary proteins. Atherosclerosis. 203:8–17.
   PubMed Web of Science ®Google Scholar
• Souza, L.M., Riera, R., Saconato, H., Demathé, A. and Atallah, A.N. (2009). Oral drugs for hypertensive urgencies: Systematic review and meta-analysis. Sao Paulo Med. J. 127:366–372.
   PubMed Web of Science ®Google Scholar
• Suetsuna, K. (1998). Isolation and characterization of angiotensin I-converting enzyme inhibitor dipeptides derived from Allium sativum L (garlic). J. Nutr. Biochem. 9:415–419.
   Web of Science ®Google Scholar
• Suetsuna, K., Maekawa, K. and Chen, J.R. (2004). Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats. J. Nutr. Biochem. 15:267–272.
   PubMed Web of Science ®Google Scholar
• Suetsuna, K. and Nakano, T. (2000). Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida). J. Nutr. Biochem. 11:450–454.
   PubMed Web of Science ®Google Scholar
• Tauzin, J., Miclo, L. and Gaillard, J.L. (2002). Angiotensin-I-converting enzyme inhibitory peptides from tryptic hydrolysate of bovine alpha(S2)-casein. FEBS Lett. 531:369–374.
   PubMed Web of Science ®Google Scholar
• Tokunaga, K.H., Yoshida, C., Suzuki, K.M., Maruyama, H., Futamura, Y., Araki, Y. and Mishima, S. (2004). Antihypertensive effect of peptides from Royal Jelly in spontaneously hypertensive rats. Biol. Pharm. Bull. 27:189–192.
   PubMed Web of Science ®Google Scholar
• Tonouchi, H., Suzuki, M., Uchida, M. and Oda, M. (2008). Antihypertensive effect of an angiotensin converting enzyme inhibitory peptide from enzyme modified cheese. J. Dairy Res. 75:284–290.
   PubMed Web of Science ®Google Scholar
• Tovar-Perez, E.G., Guerrero-Legarreta, I., Farres-Gonzalez, A. and Soriano-Santos, J. (2009). Angiotensin I-converting enzyme-inhibitory peptide fractions from albumin 1 and globulin as obtained of amaranth grain. Food Chem. 116:437–444.
   Web of Science ®Google Scholar
• Van Dyck, S., Vissers, S., Van Schepdael, A. and Hoogmartens, J. (2003). Kinetic study of angiotensin converting enzyme activity by capillary electrophoresis after in-line reaction at the capillary inlet. J. Chromatogr. A. 986:303–311.
   PubMed Web of Science ®Google Scholar
• Vercruysse, L., Smagghe, G., Herregods, G. and Van Camp, J. (2005). ACE inhibitory activity in enzymatic hydrolysates of insect protein. J. Agric. Food Chem. 53:5207–5211.
   PubMed Web of Science ®Google Scholar
• Vermeirssen, V., Augustijns, P., Morel, N., Van Camp, J., Opsomer, A. and Verstraete, W. (2005). In vitro intestinal transport and antihypertensive activity of ACE inhibitory pea and whey digests. Int. J. Food Sci. Nutr. 56:415–430.
   PubMed Web of Science ®Google Scholar
• Wang, W. and de Mejia, E.G. (2005). A new frontier in soy bioactive peptides that may prevent age-related diseases. Comp. Rev. Food Sci. Food Safety. 4:63–78.
   PubMed Web of Science ®Google Scholar
• Vermeirssen, V., Van Camp, J. and Verstraete, W. (2002). Optimisation and validation of an angiotensin-converting enzyme inhibition assay for the screening of bioactive peptides. J. Biochem. Biophys. Methods. 51:75–87.
   PubMedGoogle Scholar
• Vermeirssen, V., Van Camp, J. and Verstraete, W. (2004). Bioavailability of angiotensin I converting enzyme inhibitory peptides. Br. J. Nutr. 92:357–366.
   PubMed Web of Science ®Google Scholar
• Wang, Y.K., He, H.L., Chen, X.L., Sun, C.Y., Zhang, Y.Z. and Zhou, B.C. (2008b). Production of novel angiotensin I-converting enzyme inhibitory peptides by fermentation of marine shrimp Acetes chinensis with Lactobacillus fermentum SM 605. Appl. Microbiol. Biotechnol. 79:785–791.
   PubMed Web of Science ®Google Scholar
• Wang, J.P., Hu, J.E., Cui, J.Z., Bai, X.F., Du, Y.G., Miyaguchi, Y. and Lin, B.C. (2008a). Purification and identification of an ACE inhibitory peptide from oyster proteins hydrolysate and the anti-hypertensive effect of hydrolysate in spontaneously hypertensive rats. Food Chem. 111:302–308.
   PubMed Web of Science ®Google Scholar
• Wu, J., Aluko, R.E. and Muir, A.D. (2002). Improved method for direct high-performance liquid chromatography assay of angiotensin-converting enzyme-catalyzed reactions. J. Chromatogr. A. 950:125–130.
   PubMed Web of Science ®Google Scholar
• Yamamoto, N., Ejiri, M. and Mizuno, S. (2003). Biogenic peptides and their potential use. Curr. Pharm. Des. 9:1345–1355.
   PubMed Web of Science ®Google Scholar
• Yamamoto, N., Maeno, M. and Takano, T. (1999). Purification and characterization of an antihypertensive peptide from a yogurt-like product fermented by Lactobacillus helveticus CPN4. J. Dairy Sci. 82:1388–1393.
   PubMed Web of Science ®Google Scholar
• Yamamoto, N. and Takano, T. (1999). Antihypertensive peptides derived from milk proteins. Nahrung. 43:159–164.
   PubMedGoogle Scholar
• Yang, Y.J., Marczak, E.D., Yokoo, M., Usui, H. and Yoshikawa, M. (2003). Isolation and antihypertensive effect of angiotensin I-converting enzyme (ACE) inhibitory peptides from spinach Rubisco. J. Agric. Food Chem. 51:4897–4902.
   PubMed Web of Science ®Google Scholar
• Yang, Y., Tao, G., Liu, P. and Liu, J. (2007). Peptide with angiotensin I-converting enzyme inhibitory activity from hydrolyzed corn gluten meal. J. Agric. Food Chem. 55:7891–7895.
   PubMed Web of Science ®Google Scholar
• Yano, S., Suzukim, K. and Funatsum, G. (1996). Isolation from α-zein of thermolysin peptides with angiotensin I-converting enzyme inhibitory activity. Biosci. Biotech. Biochem. 60:661–663.
   PubMed Web of Science ®Google Scholar
• Yokoyama, K., Chiba, H. and Yoshikawa, M. (1991). Peptide inhibitors for angiotensin-I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem. 56:1541–1545.
   Web of Science ®Google Scholar
• Yu, Y., Hu, J.N., Miyaguchi, Y.J., Bai, X.F., Du, Y.G. and Lin, B.C. (2006). Isolation and characterization of angiotensin I-converting enzyme inhibitory peptides derived from porcine hemoglobin. Peptides. 27:2950–2956.
   PubMed Web of Science ®Google Scholar
• Zhang, C.H., Cao, W.H., Hong, P.Z., Ji, H.W., Qin, X.M. and He, J. (2009). Angiotensin I-converting enzyme inhibitory activity of Acetes chinensis peptic hydrolysate and its antihypertensive effect in spontaneously hypertensive rats. Int. J. Food Sci. Technol. 44:2042–2048.
   Web of Science ®Google Scholar
• Zhang, J.H., Tatsumi, E., Ding, C.H. and Li, L.T. (2006). Angiotensin I-converting enzyme inhibitory peptides in douchi, a Chinese traditional fermented soybean product. Food Chem. 98:551–557.
   Web of Science ®Google Scholar
• Zhao, Y.H., Li, B.F., Dong, S.Y., Liu, Z.Y., Zhao, X., Wang, J.F. and Zeng, M.Y. (2009). A novel ACE inhibitory peptide isolated from Acaudina molpadioidea hydrolysate. Peptides. 30:1028–1033.
   PubMed Web of Science ®Google Scholar
• Zhao, Y.H., Li, B.F., Liu, Z.Y., Dong, S.Y., Zhao, X. and Zeng, M.Y. (2007). Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate. Process Biochem. 42:1586–1591.
   Web of Science ®Google Scholar
• Zhu, X.L., Watanabe, K., Shiraishi, K., Ueki, T., Noda, Y., Matsui, T. and Matsumoto, K. (2008). Identification of ACE-inhibitory peptides in salt-free soy sauce that are transportable across caco-2 cell monolayers. Peptides. 29:338–344.
   PubMed Web of Science ®Google Scholar
• Zimecki, M. and Kruzel, M.L. (2007). Milk-derived proteins and peptides of potential therapeutic and nutritive value. J. Exp. Ther. Oncol. 6:89–106.
   PubMedGoogle Scholar