Tea and Its Consumption: Benefits and Risks

REFERENCES

• Abeywickramaa, K., Ratnasooriya, W. and Amarakoon, A. (2011). Oral hypoglycaemic, antihyperglycaemic and antidiabetic activities of Sri Lankan Broken Orange Pekoe Fannings (BOPF) grade black tea (Camellia sinensis L.) in rats. J. Ethnopharmacol. 135:278–286.
   PubMed Web of Science ®Google Scholar
• Adak, M. and Gabar, M. (2011). Green tea as a functional food for better health: A brief review. Res. J. Pharmaceut., Biol. Chem. Sci. 2:645–664.
   Google Scholar
• Adhikary, B., Yadav, S., Roy, K., Bandyopadhyay, S. and Chattopadhyay, S. (2011). Black tea and theaflavins assist healing of indomethacin-induced gastric ulceration in mice by antioxidative action. Evid. Based Complemen. Alternat. Med. 2011:11.
   Web of Science ®Google Scholar
• Alexis, A., Jones, V. and Stiller, M. (1999). Potential therapeutic applications of tea in dermatology. Int. J. Dermatol. 38:735–743.
   PubMed Web of Science ®Google Scholar
• Alexopoulos, N., Vlachopoulos, C., Aznaouridis, K., Baou, K., Vasiliadou, C., Pietri, P., Xaplanteris, P., Stefanadi, E. and Stefanadis, C. (2008). The acute effect of green tea consumption on endothelial function in healthy individuals. J. Cardiovascul. Risk. 15:300–305.
   Google Scholar
• Arab, L., Liu, W. and Elashoff, D. (2009). Green and black tea consumption and risk of stroke: A meta-analysis. Stroke. 40:1786–1792.
   PubMed Web of Science ®Google Scholar
• Bahoruna, T., Luximon-Ramma, A., Gunness, T., Sookar, D., Bhoyroo, S., Jugessur, R., Reebye, D., Googoolye, K., Crozier, A. and Aruoma, O. (2010). Black tea reduces uric acid and C-reactive protein levels in humans susceptible to cardiovascular diseases. Toxicology. 278:68–74.
   PubMed Web of Science ®Google Scholar
• Bandyopadhyay, D., Chatterjee, T., Dasgupta, A., Lourduraja, J. and Dastidar, S. (2005). In vitro and in vivo antimicrobial action of tea: The commonest beverage of Asia. Biol. Pharm. Bull. 28:2125–2127.
   PubMed Web of Science ®Google Scholar
• Banerjee, S., Manna, S., Saha, P., Panda, C. and Das, S. (2005). Black tea polyphenols suppress cell proliferation and induce apoptosis during benzo(a)pyrene-induced lung carcinogenesis. Eur. J. Cancer Prev. 14:215–221.
   PubMed Web of Science ®Google Scholar
• Beltz, L., Bayer, D., Moss, A. and Simet, I. (2006). Mechanisms of cancer prevention by green and black tea polyphenols. Anticancer Agents Med. Chem. 6:389–406.
   PubMedGoogle Scholar
• Bonkovsky, H. (2006). Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis). Ann. Intern. Med. 144:68–71.
   PubMed Web of Science ®Google Scholar
• Butt, S. and Sultan, M. (2009). Green tea: Nature's defense against malignancies. Cri. Rev. Food Sci. Nutr. 49:463–473.
   PubMed Web of Science ®Google Scholar
• Cabrera, C., Artacho, R. and Giménez, R. (2006). Beneficial effects of green tea - A review. J. Am. College Nutr. 25:79–99.
   PubMed Web of Science ®Google Scholar
• Cao, J., Bai, X., Zhao, Y., Liu, J., Zhou, D., Fang, S., Jia, M. and Wu, J. (1996). The relationship of fluorosis and brick tea drinking in Chinese Tibetans. Environ. Health Persp. 104:1340–1343.
   PubMed Web of Science ®Google Scholar
• Castellsague, X., Munoz, N., De Stefani, E., Victora, C., Castelletto, R. and Rolón, P. (2000). Influence of mate drinking, hot beverages and diet on esophageal cancer risk in South America. Int. J. Cancer. 88:658–664.
   PubMed Web of Science ®Google Scholar
• Chen, Z., Petinger, M., Ritenbaugh, C., LaCroix, A., Robbins, J. and Caan, B. (2003). Habitual tea consumption and risk of osteoporosis: A prospective study in the Women's Health Initiative Observational Cohort. Am. J. Epidemiol. 158:772–781.
   PubMed Web of Science ®Google Scholar
• Chow, H., Cai, Y., Hakim, I., Crowell, J., Shahi, F., Brooks, C., Dorr, R., Hara, Y. and Alberts, D. (2003). Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin. Cancer Res. 9:3312–3319.
   PubMed Web of Science ®Google Scholar
• Chow, H., Hakim, I., Vining, D., Crowell, J., Ranger-Moore, J., Chew, W., Celaya, C., Rodney, S., Hara, Y. and Alberts, D. (2005). Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of polyphenon E in healthy individuals. Clin. Cancer Res. 11:4627–4633.
   PubMed Web of Science ®Google Scholar
• Conney, A., Lu, Y., Lou, Y., Xie, J. and Huang, M. (1999). Inhibitory effect of green and black tea on tumor growth. Proc. Soc. Exp. Biol. Med. 220:229–233.
   PubMed Web of Science ®Google Scholar
• Das, D., Mukherjee, S., Das, A., Mukherjee, M. and Mitra, C. (2006). Aqueous extract of black tea (Camellia sinensis) prevents ethanol + cholecystokinin-induced pancreatitis in a rat model. Life Sci. 78:2194–2203.
   PubMed Web of Science ®Google Scholar
• Debette, S., Courbon, D., Leone, N., Gariepy, J., Tzourio, C., Dartigues, J., Barberger-Gateau, P., Ritchie, K., Alperovitch, A., Amouyel, P., Ducimetiere, P. and Zureik, M. (2008). Tea consumption is inversely associated with carotid plaques in women. Arteriosclerosis, Thromb. Vas. Biol. 28:353–359.
   PubMed Web of Science ®Google Scholar
• Erba, D., Riso, P., Bordoni, A., Foti, P., Biagi, P. and Testolin, G. (2005). Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans. J. Nutr. Biochem. 16:144–149.
   PubMed Web of Science ®Google Scholar
• Fung, K., Zhang, Z., Wong, J. and Wong, M. (1999). Fluoride contents in tea and soil from tea plantations and the release of fluoride into tea liquor during infusion. Environ. Pollut. 104:197–205.
   Web of Science ®Google Scholar
• Galati, G., Lin, A., Sultan, A. and O’Brien, P. (2006). Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins. Free Radical Biol. Med. 40:570–580.
   PubMed Web of Science ®Google Scholar
• Gao, Y., McLaughlin, J., Blot, W., Ji, B., Dai, Q. and Fraumeni, J. (1994). Reduced risk of esophageal cancer associated with green tea consumption. J. Nat. Cancer Inst. 86:855–858.
   PubMed Web of Science ®Google Scholar
• Gardner, E., Ruxton, C. and Leeds, A. (2007). Black tea - helpful or harmful? A review of the evidence. Eur. J. Clin. Nutr. 61:3–18.
   PubMed Web of Science ®Google Scholar
• Gulati, P., Singh, V., Gupta, M., Vaidya, V., Dass, S. and Prakash, S. (1993). Studies on the leaching of fluoride in tea infusions. Sci. Total Environ. 138:213–222.
   PubMed Web of Science ®Google Scholar
• Gupta, S., Saha, B. and Giri, A. (2002). Comparative antimutagenic and anticlastogenic effects of green tea and black tea: A review. Mutat. Res. 512:97–65.
   Web of Science ®Google Scholar
• Hara, N., Sakata, K., Nagai, M., Fujita, Y., Hashimoto, T. and Yanagawa, H. (1984). Statistical analyses on the pattern of food consumption and digestive-tract cancers in Japan. Nutr. Cancer. 6:220–228.
   PubMedGoogle Scholar
• Hawkey, C. (1990). Non-steroidal anti-inflammatory drugs and peptic ulcers. Facts and figures multiply, but do they add up? Brit. Med. J. 300:278–284.
   PubMed Web of Science ®Google Scholar
• Hegarty, V., May, H. and Khaw, K. (2000). Tea drinking and bone mineral density in older women. Am. J. Clin. Nutr. 71:1003–1007.
   PubMed Web of Science ®Google Scholar
• Higdon, J. and Frei, B. (2006). Coffee and health: A review of recent human research. Cri. Rev. Food Sci. Nutr. 46:101–123.
   PubMed Web of Science ®Google Scholar
• Hodgson, J. and Croft, K. (2006). Dietary flavonoids: Effects on endothelial function and blood pressure. J. Sci. Food Agr. 86:2492–2498.
   Web of Science ®Google Scholar
• Huang, Y., Liu, Y., Dushenkov, S., Ho, C. and Huang, M. (2009). Anti-obesity effects of epigallocatechin-3-gallate, orange peel extract, black tea extract, caffeine and their combinations in a mouse model. J. Funct. Foods. 1:304–310.
   Web of Science ®Google Scholar
• Ide, R., Fujino, Y., Hoshiyama, Y., Mizoue, T., Kubo, T., Pham, T., Shirane, K., Tokui, N., Sakata, K., Tamakoshi, A. and Yoshimura, T. (2007). A prospective study of green tea consumption and oral cancer incidence in Japan. Ann. Epidemiol. 17:821–826.
   PubMed Web of Science ®Google Scholar
• Il’yasova, D., Arab, L., Martinchik, A., Sdvizhkov, A., Banovich, L. and Weisgerber, U. (2003). Black tea consumption and risk of rectal cancer in Moscow population. Ann. Epidemiol. 13:405–411.
   PubMed Web of Science ®Google Scholar
• Isbrucker, R., Edwards, J., Wolz, E., Davidovich, A. and Bausch, J. (2006). Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: Dermal, acute and short-term toxicity studies. Food Chem. Toxicol. 44:636–650.
   PubMed Web of Science ®Google Scholar
• Ishikawa, A., Kuriyama, S., Tsubono, Y., Fukao, A., Takahashi, H., Tachiya, H. and Tsuji, I. (2006). Smoking, alcohol drinking, green tea consumption and the risk of esophageal cancer in Japanese men. J. Epidemiol. 16:185–192.
   PubMed Web of Science ®Google Scholar
• Islami, F., Boffetta, P., Ren, J., Pedoeim, L., Khatib, D. and Kamangar, F. (2009a). High-temperature beverages and foods and esophageal cancer risk- A systematic review. Int. J. Cancer. 125:491–524.
   PubMed Web of Science ®Google Scholar
• Islami, F., Pourshams, A., Nasrollahzadeh, D., Kamangar, F., Fahimi, S., Shakeri, R., Abedi-Ardekani, B., Merat, S., Vahedi, H., Semnani, S., Abnet, C., Brennan, P., Møller, H., Saidi, F., Dawsey, S., Malekzadeh, R. and Boffetta, P. (2009b). Tea drinking habits and oesophageal cancer in a high risk area in northern Iran: Population based case-control study. Brit. Med. J. 338:929.
   PubMed Web of Science ®Google Scholar
• Jochmann, N., Lorenz, M., Krosigk, A., Martus, P., Böhm, V., Baumann, G., Stangl, K. and Stangl, V. (2008). The efficacy of black tea in ameliorating endothelial function is equivalent to that of green tea. Brit. J. Nutr. 99:863–868.
   PubMed Web of Science ®Google Scholar
• Johnell, O., Gullberg, B., Kanis, J., Allander, E., Elffors, L., Dequeker, J., Dilsen, G., Gennari, C., Vaz, L., Lyritis, G., Mazzuoli, G., Miravet, L., Passeri, M., Cano, P., Rapado, A. and Ribot, C. (1995). Risk factors for hip fracture in European women: The MEDOS study. J. Bone Mineral Res. 10:1802–1815.
   PubMed Web of Science ®Google Scholar
• Juneja, L., Chu, D., Okubo, T., Nagato, Y. and Yokogoshi, H. (1999). L-theanine—A unique amino acid of green tea and its relaxation effect in humans. Trend. Food Sci. Technol. 10:199–204.
   Web of Science ®Google Scholar
• Kanis, J., Johnell, O., Gullberg, B., Allander, E., Elffors, L., Ranstam, J., Dequeker, J., Dilsen, G., Gennari, C., Vaz, A., Lyritis, G., Mazzuoli, G., Miravet, L., Passeri, M., Cano, R., Rapado, A. and Ribot, C. (1999). Risk factors for hip fracture in men from Southern Europe: The MEDOS study. Mediterranean Osteoporosis Study. Osteoporosis Int. 9:45–54.
   PubMed Web of Science ®Google Scholar
• Kapetanovic, I., Crowell, J., Krishnaraj, R., Zakharov, A., Lindeblad, M. and Lyubimov, A. (2009). Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs. Toxicology. 260:28–36.
   PubMed Web of Science ®Google Scholar
• Katiyar, S., Elmets, C. and Katiyar, S. (2007). Green tea and skin cancer: Photoimmunology, angiogenesis and DNA repair. J. Nutr. Biochem. 18:287–296.
   PubMed Web of Science ®Google Scholar
• Kavcar, P., Odabasi, M., Kitis, M., Inal, F. and Sofuoglu, S. (2006). Occurrence, oral exposure and risk assessment of volatile organic compounds in drinking water for Izmir. Water Res. 40:3219–3230.
   PubMed Web of Science ®Google Scholar
• Ke, L., Yu, P., Zhang, Z., Huang, S., Huang, G. and Ma, X. (2002). Congou tea drinking and oesophageal cancer in South China. Brit. J. Cancer. 86:346–347.
   PubMed Web of Science ®Google Scholar
• Khan, N. and Mukhtar, H. (2007). Tea polyphenols for health promotion. Life Sci. 81:519–533.
   PubMed Web of Science ®Google Scholar
• Kim, H., Rajaiah, R., Wu, Q., Satpute, S., Tan, M., Simon, J., Berman, B. and Moudgil, K. (2008). Green tea protects rats against autoimmune arthritis by modulating disease-related immune events. J. Nutr. 138:2111–2116.
   PubMed Web of Science ®Google Scholar
• Kondo, K., Kurihara, M., Miyata, N., Suzuki, T. and Toyoda, M. (1999). Scavenging mechanisms of (−)-epigallocatechin gallate and (−)-epicatechin gallate on peroxyl radicals and formation of superoxide during the inhibitory action. Free Radical Biol. Med. 27:855–863.
   PubMed Web of Science ®Google Scholar
• Kuo, K., Weng, M., Chiang, C., Tsai, Y., Lin-Shiau, S. and Lin, J. (2005). Comparative studies on the hypolipidemic and growth suppressive effects of oolong, black, pu-erh, and green Tea leaves in rats. J. Agr. Food Chem. 53:480–489.
   PubMed Web of Science ®Google Scholar
• Lambert, J., Kennett, M., Sang, S., Reuhl, K., Ju, J. and Yang, C. (2010). Hepatotoxicity of high oral dose (–)-epigallocatechin-3-gallate in mice. Food Chem. Toxicol. 48:409–416.
   PubMed Web of Science ®Google Scholar
• Lambert, J., Sang, S. and Yang, C. (2007). Possible controversy over dietary polyphenols: Benefits vs risks. Chem. Res. Toxicol. 20:583–585.
   PubMed Web of Science ®Google Scholar
• Landau, J., Wang, Z., Yang, G., Ding, W. and Yang, C. (1998). Inhibition of spontaneous formation of lung tumors and rhabdomyosarcomas in A/J mice by black and green tea. Carcinogenesis. 19:501–507.
   PubMed Web of Science ®Google Scholar
• La Vecchia, C., Negri, E., Franceschi, S., D’Avanzo, B. and Boyle, P. (1992). Tea consumption and cancer risk. Nutr. Cancer. 17:27–31.
   PubMed Web of Science ®Google Scholar
• Leong, H., Mathur, P. and Greene, G. (2008). Inhibition of mammary tumorigenesis in the C3 (1)/SV40 mouse model by green tea. Breast Cancer Res. Treatment. 107:359–369.
   PubMed Web of Science ®Google Scholar
• Leung, L., Su, Y., Chen, R., Zhang, Z., Huang, Y. and Chen, Z.-Y. (2001). Theaflavins in black tea and catechins in green tea are equally effective antioxidants. J. Nutr., 131:2248–2251.
   PubMed Web of Science ®Google Scholar
• Lin, J. and Lin-Shiau, S. (2006). Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols. Mol. Nutr. Food Res. 50:211–217.
   PubMed Web of Science ®Google Scholar
• Lin, D., Tu, Y. and Zhu, L. (2005). Concentrations and health risk of polycyclic aromatic hydrocarbons in tea. Food Chem. Toxicol. 43:41–48.
   PubMed Web of Science ®Google Scholar
• Lin, D. and Zhu, L. (2004). Polycyclic aromatic hydrocarbons: Pollution and source analysis of a black tea. J. Agr. Food Chem. 52:8268–8271.
   PubMed Web of Science ®Google Scholar
• Loke, W., Hodgson, J., Proudfoot, J., McKinley, A., Puddey, I. and Croft, K. (2008). Pure dietary flavonoids quercetin and (–)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. Am. J. Clin. Nutr. 88:1018–1025.
   PubMed Web of Science ®Google Scholar
• Loke, W., Proudfoot, J., Hodgson, J., McKinley, A., Hime, N., Magat, M., Stocker, R. and Croft, K. (2010). Specific dietary polyphones attenuate atherosclerosis in Apolipoprotein E knockout mice by alleviating inflammation and endothelial dysfunction. Arteriosclerosis, Thromb. Vasc. Biol. 30:749–757.
   PubMed Web of Science ®Google Scholar
• Lu, Y., Lou, Y., Xie, J., Yen, P., Huang, M. and Conney, A. (1997). Inhibitory effect of black tea on the growth of established skin tumors in mice: Effects on tumor size, apoptosis, mitosis and bromodeoxyuridine incorporation into DNA. Carcinogenesis. 18:2163–2169.
   PubMed Web of Science ®Google Scholar
• Lung, S., Hsiao, P. and Chiang, K. (2003). Fluoride concentrations in three types of commercially packed tea drinks in Taiwan. J. Exposure Anal. Environ. Epidemiol. 13:66–73.
   PubMedGoogle Scholar
• Lyn-cook, B., Rogers, T., Yan, Y., Blann, E., Kadlubar, F. and Hammons, G. (1999). Chemopreventive effects of tea extracts and various components on human pancreatic and prostate tumor cells in vitro. Nutr. Cancer. 35:80–86.
   PubMed Web of Science ®Google Scholar
• Martins, M., Martins, H. and Bernardo, F. (2001). Fumonisins B1 and B2 in black tea and medicinal plants. J. Food Prot. 64:1268–1270.
   PubMed Web of Science ®Google Scholar
• Mashberg, A., Boffetta, P., Winkelman, R. and Garfinkel, L. (1993). Tobacco smoking, alcohol drinking, and cancer of the oral cavity and oropharynx among US veterans. Cancer. 72:1369–1375.
   PubMed Web of Science ®Google Scholar
• Mazzanti, G., Menniti-Ippolito, F., Moro, P., Cassetti, F., Raschetti, R., Santuccio, C. and Mastrangelo, S. (2009). Hepatotoxicity from green tea: A review of the literature and two unpublished cases. Eur. J. Clin. Pharmacol. 65:331–341.
   PubMed Web of Science ®Google Scholar
• Molinari, M., Watt, K., Kruszyna, T., Nelson, R., Walsh, M., Huang, W., Nashan, B. and Peltekian, K. (2006). Acute liver failure induced by green tea extracts: Case report and review of the literature. Liver Transplant. 12:1892–1895.
   PubMed Web of Science ®Google Scholar
• Moore, R., Jackson, K. and Minihane, A. (2009). Green tea (Camellia sinensis) catechins and vascular function. Brit. J. Nutr. 102:1790–1802.
   PubMed Web of Science ®Google Scholar
• Mukhtar, H. and Ahmad, N. (2000). Tea polyphenols: Prevention of cancer and optimizing health. Am. J. Clin. Nutr. 71:1698S–1702S.
   PubMed Web of Science ®Google Scholar
• Murase, T., Nagasawa, A., Suzuki, J., Hase, T. and Tokimitsu, I. (2002). Beneficial effects of tea catechins on diet-induced obesity: Stimulation of lipid catabolism in the liver. Int. J. Obes. Relat. Metab. Disord. 26:1459–1464.
   PubMed Web of Science ®Google Scholar
• Mursu, J., Nurmi, T., Tuomainen, T., Ruusunen, A., Salonen, J. and Voutilainen, S. (2007). The intake of flavonoids and carotid atherosclerosis: The Kuopio ischaemic heart disease risk factor study. Brit. J. Nutr. 98:814–818.
   PubMed Web of Science ®Google Scholar
• Mu, L., Zhou, X., Ding, B., Wang, R., Zhang, Z., Chen, C., Wei, G., Zhou, X., Jiang, Q. and Yu, S. (2003). A case-control study on drinking green tea and decreasing risk of cancers in the alimentary canal among cigarette smokers and alcohol drinkers. Zhonghua Liu Xing Bing Xue Za Zhi. 24:192–195.
   PubMedGoogle Scholar
• Myung, S., Bae, W., Oh, S., Kim, Y., Ju, W., Sung, J., Lee, Y., Ko, J., Song, J. and Choi, H. (2009). Green tea consumption and risk of stomach cancer: A meta-analysis of epidemiologic studies. Int. J. Cancer. 124:670–677.
   PubMed Web of Science ®Google Scholar
• Naldi, L., Gallus, S., Tavani, A., Imberti, G. and La Vecchia, C. (2004). Risk of melanoma and vitamin A, coffee and alcohol: A case-control study from Italy. Eur. J. Cancer Prev. 13:503–508.
   PubMed Web of Science ®Google Scholar
• Nance, C. and Shearer, W. (2003). Is green tea good for HIV-1 infection? J. Allergy Clin. Immunol. 112:851–853.
   PubMed Web of Science ®Google Scholar
• Negishi, H., Xu, J., Ikeda, K., Njelekela, M., Nara, Y. and Yamory, Y. (2004). Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. J. Nutr. 134:38–42.
   PubMed Web of Science ®Google Scholar
• Nelson, M. and Poulter, J. (2004). Impact of tea drinking on iron status in the UK: A review. J. Human Nutr. Diet. 17:43–54.
   PubMed Web of Science ®Google Scholar
• Niu, K., Hozawa, A., Kuriyama, S., Ebihara, S., Guo, H., Nakaya, N., Ohmori-Matsuda, K., Takahashi, H., Masamune, Y., Asada, M., Sasaki, S., Arai, H., Awata, S., Nagatomi, R. and Tsuji, I. (2009). Green tea consumption is associated with depressive symptoms in the elderly. Am. J. Clin. Nutr. 90:1615–1622.
   PubMed Web of Science ®Google Scholar
• Nookabkaew, S., Rangkadilok, N. and Satayavidad, J. (2006). Determination of trace elements in herbal tea products and their infusions consumed in Thailand. J. Agr. Food Chem. 54:6939–6944.
   PubMed Web of Science ®Google Scholar
• Notani, P. and Jayant, K. (1987). Role of diet in upper aerodigestive tract cancers. Nutr. Cancer. 10:103–113.
   PubMedGoogle Scholar
• Panagiotakos, D., Lionis, C., Zeimbekis, A., Gelastopoulou, K., Papairakleous, N., Das, U. and Polychronopoulos, E. (2009). Long-term tea intake is associated with reduced prevalence of (type 2) diabetes mellitus among elderly people from Mediterranean islands: MEDIS epidemiological study. Yonsei Med. J. 50:31–38.
   PubMed Web of Science ®Google Scholar
• Parkin, D., Bray, F., Ferlay, J. and Pisani, P. (2005). Global cancer statistics, 2002. CA-A Cancer J. Clin. 55:74–108.
   PubMed Web of Science ®Google Scholar
• Pearson, R. and McCloy, R. (1989). Preference for hot drinks is associated with peptic disease. Gut. 30:1201–1205.
   PubMed Web of Science ®Google Scholar
• Pintos, J., Franco, E., Oliveira, B., Kowalski, L., Curado, M. and Dewar, R. (1994). Mate, coffee, and tea consumption and risk of cancers of the upper aerodigestive tract in southern Brazil. Epidemiology. 5:583–590.
   PubMed Web of Science ®Google Scholar
• Prystai, E., Kies, C. and Driskell, J. (1999). Calcium, copper, iron, magnesium and zinc utilization of humans as affected by consumption of black, decaffeinated black and green teas. Nutr. Res. 19:167–177.
   Web of Science ®Google Scholar
• Ramaa, C., Shirode, A., Mundada, A. and Kadam, V. (2006). Nutraceuticals an emerging era in the treatment and prevention of cardiovascular diseases. Curr. Pharm. Biotechnol. 7:15–23.
   PubMed Web of Science ®Google Scholar
• Ravindranath, M., Saravanan, T., Monteclaro, C., Presser, N., Ye, X., Selvan, S. and Brosman, S. (2006). Epicatechins purified from green tea (Camellia sinensis) differentially suppress growth of gender-dependent human cancer cell lines. Evid. Based Complement. Altern. Med. 3:237–247.
   PubMed Web of Science ®Google Scholar
• Ren, J., Freedman, N., Kamangar, F., Dawsey, S., Hollenbeck, A., Schatzkin, A. and Abnet, C. (2010). Tea, coffee, carbonated soft drinks and upper gastrointestinal tract cancer risk in a large United States prospective cohort study. Eur. J. Cancer. 46:1873–1881.
   PubMed Web of Science ®Google Scholar
• Ripple, M., Henry, W., Rago, R. and Wilding, G. (1997) Prooxidant–antioxidant shift induced by androgen treatment of human prostate carcinoma cells. J. Natl. Cancer Inst. 89:40–48.
   PubMed Web of Science ®Google Scholar
• Roberts, B. and Shorter, J. (2008). Escaping amyloid fate. Nat. Struct. Molecular Biol. 15:544–546.
   PubMed Web of Science ®Google Scholar
• Ross, J., Potter, J. and Robison, L. (1994). Infant leukemia, topoisomerase II inhibitors, and the MLL gene. J. Natl Cancer Inst. 86:1678–1680.
   PubMed Web of Science ®Google Scholar
• Sartippour, M., Pietras, R., Marquez-Garban, D., Chen, H., Heber, D., Henning, S., Sartippour, G., Zhang, L., Lu, M., Weinberg, O., Rao, J. and Brooks, M.N. (2006). The combination of green tea and tamoxifen is effective against breast cancer. Carcinogenesis. 27:2424–2433.
   PubMed Web of Science ®Google Scholar
• Schönthal, A. (2011). Adverse effects of concentrated green tea extracts. Mol. Nutr. Food Res. 55:874–885.
   PubMed Web of Science ®Google Scholar
• Shankar, S., Ganapathy, S. and Srivastava, R. (2007). Green tea polyphenols, biology and therapeutic implications in cancer. Front Bioscience. 1:4881–4899.
   Web of Science ®Google Scholar
• Sharangi, A. (2009). Medicinal and therapeutic potentialities of tea (Camellia sinensis L.). Food Res. Int. 42:529–535.
   Web of Science ®Google Scholar
• Shim, J., Kang, M., Kim, Y., Roberts, C. and Lee, I. (1995). Chemopreventive effect of green tea (Camellia sinensis) among cigarette smoke. Epidemiol. Biomarkers Prev. 4:387–391.
   PubMed Web of Science ®Google Scholar
• Shirai, T., Sato, A. and Hara, Y. (1994). Epigallocatechin gallate. The major causative agent of green tea-induced asthma. Chest. 106:1801–1805.
   PubMed Web of Science ®Google Scholar
• Siddiqui, I., Raisuddin, S. and Shukla, Y. (2005). Protective effects of black tea extract on testosterone induced oxidative damage in prostate. Cancer Lett. 227:125–132.
   PubMed Web of Science ®Google Scholar
• Smart, D., Ortiz, K., Mattson, D., Bradbury, C., Bisht, K., Sieck, L., Brechbiel, M. and Gius, D. (2004). Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress. Cancer Res. 64:6716–6724.
   PubMed Web of Science ®Google Scholar
• Sofuoglu, S. and Kavcar, P. (2008). An exposure and risk assessment for fluoride and trace metals in black tea. J. Hazard. Mater. 158:392–400.
   PubMed Web of Science ®Google Scholar
• Steptoe, A., Gibson, E., Vuononvirta, R., Hamer, M., Wardle, J., Rycroft, J., Martin, J. and Erusalimsky, J. (2007). The effects of chronic tea intake on platelet activation and inflammation: A double-blind placebo controlled trial. Atherosclerosis. 193:277–282.
   PubMed Web of Science ®Google Scholar
• Sun, Y. (1990). Free radicals, antioxidant enzymes and carcinogenesis. Free Radical Biol. Med. 8:583–599.
   PubMed Web of Science ®Google Scholar
• Sun, C., Yuan, J., Koh, W. and Yu, M. (2006). Green tea, black tea and colorectal cancer risk: A meta-analysis of epidemiologic studies. Carcinogenesis. 27:1301–1309.
   PubMed Web of Science ®Google Scholar
• Tanaka, K., Miyake, Y., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M. and Group, F.K. P. s. D. S. (2011). Intake of Japanese and Chinese teas reduces risk of Parkinson's disease. Parkinsonism Related Disorders. 17:446–450.
   PubMed Web of Science ®Google Scholar
• Tatti, S., Swinehart, J., Thielert, C., Tawfik, H., Mescheder, A. and Beutner, K. (2008). Sinecatechins, a defined green tea extract, in the treatment of external anogenital warts: A randomized controlled trial. Obstet. Gynecol. 111:1371–1379.
   PubMed Web of Science ®Google Scholar
• Tavani, A., Bertuzzi, M., Talamini, R., Gallus, S., Parpinel, M., Franceschi, S., Levi, F. and La Vecchia, C. (2003). Coffee and tea intake and risk of oral, pharyngeal and esophageal cancer. Oral Oncol. 39:695–700.
   PubMed Web of Science ®Google Scholar
• Taylor, J. and Wilt, V. (1999). Probable antagonism of warfarin by green tea. Ann. Pharm. 33:426–428.
   PubMed Web of Science ®Google Scholar
• Toyoda, M., Tanaka, K., Hoshino, K., Akiyama, H., Tanimura, A. and Saito, Y. (1997). Profiles of potentially antiallergic flavonoids in 27 kinds of health tea and green tea infusions. J. Agr. Food Chem. 45:2561–2564.
   Web of Science ®Google Scholar
• Vasisht, K., Sharma, P., Karan, M., Rakesh, D., Vyas, S., Sethi, S. and Manktala, R. (2003). Study to Promote the Industrial Exploitation of Green Tea Polyphenols in India. International Centre for Science and High Technology—United Nations Industrial Development Organization, Italy.
   Google Scholar
• Wang, J., Xu, B., Rao, J., Shen, H., Xue, H. and Jiang, Q. (2007). Diet habits, alcohol drinking, tobacco smoking, green tea drinking, and the risk of esophageal squamous cell carcinoma in the Chinese population. Eur. J. Gastroen. Hepatol. 19:171–176.
   PubMed Web of Science ®Google Scholar
• Wang, D., Xu, K., Zhong, Y., Luo, X., Xiao, R., Hou, Y., Bao, W., Yang, W., Yan, H., Yao, P. and Liu, L. (2011). Acute and subchronic oral toxicities of Pu-erh black tea extract in Sprague-Dawley rats. J. Ethnopharmacol. 134:156–164.
   PubMed Web of Science ®Google Scholar
• Weisburger, J. (1999). Tea and health: The underlying mechanisms. Proc. Soc. Exp. Biol. Med. 220:271–275.
   PubMed Web of Science ®Google Scholar
• Wei, S., Xu, H., Xiong, X., Luo, Z., Audibert, F. and Fraser, W. (2009). Tea consumption during pregnancy and the risk of pre-eclampsia. Int. J. Gynecol.Obst. 105:123–126.
   PubMed Web of Science ®Google Scholar
• Whyte, M., Essmyer, K., Gannon, F. and Reinus, W. (2005). Skeletal fluorosis and instant tea. Am. J. Med. 118:78–82.
   PubMed Web of Science ®Google Scholar
• Widlansky, M., Hamburg, N., Anter, E., Holbrook, M., Kahn, D., Elliott, J., Keaney, J. and Vita, J. (2007). Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J. Am. College Nutr. 26:95–102.
   PubMed Web of Science ®Google Scholar
• Williamson, M., McCormick, T., Nance, C. and Shearer, W. (2006). Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4: Potential for HIV-1 therapy. J. Allergy Clin. Immunol. 118:1369–1374.
   PubMed Web of Science ®Google Scholar
• Wong, M., Zhang, Z., Wong, J. and Lan, C. (1998). Trace metal contents (Al, Cu and Zn) of tea: Tea and soil from two plantations, and tea products from different provinces of China. Environm. Geochem. Health. 20:87–94.
   Web of Science ®Google Scholar
• Yamamoto, T., Juneja, L., Chu, D. and Kim, M. (1997). Chemistry and Applications of Green Tea. CRC Press, LLC, Boca Raton, USA.
   Google Scholar
• Yang, C., Chung, J., Yang, G., Chhabra, S. and Lee, M. (2000). Tea and tea polyphenols in cancer prevention. J. Nutr. 130:472S–478S.
   PubMed Web of Science ®Google Scholar
• Yang, C., Ju, J., Lu, G., Xiao, H., Hao, X., Sang, S. and Lambert, J. (2008). Cancer prevention by tea and tea polyphenols. Asia Pac. J. Clin. Nutr. 17:245–248.
   PubMed Web of Science ®Google Scholar
• Yang, Y., Lu, F., Wu, J., Wu, C. and Chang, C. (2004). The protective effect of habitual tea consumption on hypertension. Arch. Internal Med. 164:1534–1540.
   PubMed Web of Science ®Google Scholar
• Yang, G., Wang, Z., Kim, S., Liao, J., Seril, D., Chen, X., Smith, T. and Yang, C. (1997). Characterization of early pulmonary hyperproliferation, tumor progression and their inhibition by black tea in a 4-(methylnitrosamino)-1-(3-pyridyl)-1 butanone (NNK)-induced lung tumorigenesis model with A/J mice. Cancer Res. 57:1889–1894.
   PubMed Web of Science ®Google Scholar
• Zheng, G., Sayama, K., Okubo, T., Juneja, L. and Oguni, I. (2004). Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine in mice. In Vivo. 18:55–62.
   PubMed Web of Science ®Google Scholar
• Zhong, L., Goldberg, M., Gao, Y., Hanley, J., Parent, M. and Jin, F. (2001). A population-based case-control study of lung cancer and green tea consumption among women living in Shanghai, China. Epidemeology. 12:695–700.
   PubMed Web of Science ®Google Scholar