Evaluation of the Impact of Ruminant Trans Fatty Acids on Human Health: Important Aspects to Consider

REFERENCES

• Albuquerque, T. G., Costa, H. S., Castilho, M. C. and Sanches-Silva, A. (2011). Trends in the analytical methods for the determination of trans fatty acids content in foods. Trends Food Sci. Technol. 22:543–560.
   Web of Science ®Google Scholar
• Almendingen, K., Jordal, O., Kierulf, P., Sandstad, B. and Perdersen, J. I. (1995). Effects of partially hydrogenated fish oil, partially hydrogenated soybean oil, and butter on serum lipoproteins and Lp[a] in men. J. Lipid. Res. 36:1370–1384.
   PubMed Web of Science ®Google Scholar
• Anadon, A., Martinez-Larranaga, M. R., Martinez, M. A., Ares, I., Ramos, E., Gomez-Cortes, P., Juarez, M. and De la Fuente, M. A. (2010). Acute oral safety study of dairy fat rich in trans-10 C18:1 versus vaccenic plus conjugated linoleic acid in rats. Food Chem. Toxicol. 48:591–598.
   PubMed Web of Science ®Google Scholar
• Ansorena, D., Echarte, A., Ollé, R. and Astiasarán, I. (2013). 2012: No trans fatty acids in Spanish bakery products. Food Chem. 138:422–429.
   PubMed Web of Science ®Google Scholar
• Aro, A., Jauhiainen, M., Partanen, R., Salminen, I. and Mutanen, M. (1997). Stearic acid, trans fatty acids, and dairy fat: Effects on serum and lipoprotein lipids, apolipoproteins, lipoprotein(a), and lipid transfer proteins in healthy subjects. Am. Clin. J. Nutr. 65:1419–1426.
   PubMed Web of Science ®Google Scholar
• Ascherio, A., Rimm, E. B., Giovannucci, E. L., Spiegelinan, D., Stampfer, M. J. and Willet, W. C. (1996). Dietary fat and risk of coronary heart disease in men, cohort follow up study in the United States. Br. Med. J. 313:84–90.
   PubMed Web of Science ®Google Scholar
• Baehr, M., Jahreis, G. and Kuhnt, K. (2011). Trans-Fettsären in Lebensmitteln auf dem deutschen Markt und in Humangeweben. Ernahr-Umsch. 58:478–485.
   Google Scholar
• Baer, D. J., Judd, J. T., Clevidence, B. A. and Tracy, R. P. (2004). Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: A randomized crossover study. Am. J. Clin. Nutr. 79:969–973.
   PubMed Web of Science ®Google Scholar
• Bassett, C. M., Edel, A. L., Patenaude, A. F., McCullough, R. S., Blackwood, D. P., Chouinard, P. Y., Paquin, P., Lamarche, B. and Pierce, G. N. (2010). Dietary vaccenic acid has antiatherogenic effects in LDLr-/- mice. J. Nutr. 140:18–24.
   PubMed Web of Science ®Google Scholar
• Baylin, A. (2013). Secular trends in trans fatty acids: Decreased trans fatty acids in the food supply are reflected in decreased trans fatty acids in plasma. Am. J. Clin. Nutr. 97:665–666.
   PubMed Web of Science ®Google Scholar
• Bendsen, N. T., Christensen, R., Bartels, E. M. and Astrup, A. (2011). Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: A systematic review and meta-analysis of cohort studies. Eur. J. Clin. Nutr. 65:773–783.
   PubMed Web of Science ®Google Scholar
• BMELV. (2012). Leitlinien zur Minimierung von Trans-Fettsäuren in Lebensmitteln. Available from http://www.bmelv.de/SharedDocs/Downloads/Ernaehrung/Rueckstaende/Trans-Fettsaeuren/TFA_Inhalt.pdf?__blob= publicationFile
   Google Scholar
• Bolton-Smith, C., Woodward, M., Fenton, S. and Brown, C. A. (1996). Does dietary trans fatty acid intake relate to the prevalence of coronary heart disease in Scotland? Eur. Heart J. 17:837–845.
   PubMed Web of Science ®Google Scholar
• Brouwer, I. A., Wanders, A. J. and Katan, M. B. (2010). Effect of animal and industrial trans fatty acids on HDL and LDL cholesterol levels in humans - a quantitative review. PLoS One. 5(3):e9434.
   PubMed Web of Science ®Google Scholar
• Butler, G., Nielsen, J. H., Larsen, M. K., Rehberger, B., Stergiadis, S., Canever, A. and Leifert, C. (2011). The effects of dairy management and processing on quality characteristics of milk and dairy products. NJAS-Wageningen J. Life Sci. 58:97–102.
   Web of Science ®Google Scholar
• Charbonneau, B., O'Connor, H. M., Wang, A. H., Liebow, M., Thompson, C. A., Fredericksen, Z. S., Macon, W. R., Slager, S. L., Call, T. G., Habermann, T. M. and Cerhan, J. R. (2013). Trans fatty acid intake is associated with increased risk and n3 fatty acid intake with reduced risk of non-Hodgkin lymphoma. J. Nutr. 143:672–681.
   PubMed Web of Science ®Google Scholar
• Chardigny, J. M., Clouet, P., Combe, N., Quignard-Boulangde, A., Schmitt, B., Lagarde, M. and Leger, C. L. (2007). Metabolism of trans and conjugated fatty acids. Eur. J. Lipid. Sci. Technol. 109:930–934.
   Web of Science ®Google Scholar
• Chardigny, J. M., Destaillats, F., Malpuech-Brugère, C., Moulin, J., Bauman, D. E., Lock, A. L., Barbano, D. M., Mensink, R. P., Bezelgues, J. B., Chaumont, P., Combe, N., Cristiani, I., Joffre, F., German, J. B., Dionisi, F., Boirie, Y. and Sébédio, J. L. (2008). Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular disease risk factors in healthy subjects? Results of the trans fatty ccids collaboration (TRANSFACT) study. Am. J. Clin. Nutr. 87:558–566.
   PubMed Web of Science ®Google Scholar
• Chilliard, Y., Glasser, F., Ferlay, A., Bernard, L., Rouel, J. and Doreau, M. (2007). Diet, rumen biohydrogenation and nutritional quality of cow and goat milk fat. Eur. J. Lipid Sci. Technol. 109:828–855.
   Web of Science ®Google Scholar
• Clifton, P. M., Keogh, J. B. and Noakes, M. (2004). Trans fatty acids in adipose tissue and the food supply are associated with myocardial infarction. J. Nutr. 134:874–879.
   PubMed Web of Science ®Google Scholar
• Corl, B. A., Barbano, D. M., Bauman, D. E. and Ip, C. (2003). cis-9, trans-11 CLA derived endogenously from trans-11 18:1 reduces cancer risk in rats. J. Nutr. 133:2893–2900.
   PubMed Web of Science ®Google Scholar
• Daley, C. A., Abbott, A., Doyle, P. S., Nader, G. A. and Larson, S. (2010). A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef. Nutr. J. 9:10. Published online March 10, 2010. doi: 10.1186/1475-2891-9-10.
   PubMed Web of Science ®Google Scholar
• Degen, C., Ecker, J., Piegholdt, S., Liebisch, G., Schmitz, G. and Jahreis, G. (2011a). Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA. Biochim. Biophys. Acta. 1811:1070–1080.
   PubMed Web of Science ®Google Scholar
• Degen, C., Lochner, A., Keller, S., Kuhnt, K., Dänicke, S. and Jahreis, G. (2011b). Influence of in vitro supplementation with lipids from conventional and Alpine milk on fatty acid distribution and cell growth of HT-29 cells. Lipids Health Dis. 10:131. Published online August 4, 2011. doi: 10.1186/1476-511X-10-131.
   PubMed Web of Science ®Google Scholar
• Desroches, S., Chouinard, P. Y., Galibois, I., Corneau, L., Delisle, J., Lamarche, B., Couture, P. and Bergeron, N. (2005). Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men. Am. J. Clin. Nutr. 82:309–319.
   PubMed Web of Science ®Google Scholar
• Destaillats, F., Golay, P. A., Joffre, F., de Wispelaere, M., Hug, B., Giuffrida, F., Fauconnot, L. and Dionisi, F. (2007). Comparison of available analytical methods to measure trans-octadecenoic acid isomeric profile and content by gas-liquid chromatography in milk fat. J. Chromatogr. A. 1145:222–228.
   PubMed Web of Science ®Google Scholar
• Destaillats, F., Wolff, R. L., Precht, D. and Molkentin, J. (2000). Study of individual trans- and cis-16:1 isomers in cow, goat, and ewe cheese fats by gas-liquid chromatography with emphasis on the trans-delta3 isomer. Lipids. 35:1027–1032.
   PubMed Web of Science ®Google Scholar
• Dilzer, A. and Park, Y. (2012). Implication of conjugated linoleic acid (CLA) in human health. Crit. Rev. Food Sci. Nutr. 52:488–513.
   PubMed Web of Science ®Google Scholar
• Doell, D., Folmer, D., Lee, H., Honigfort, M. and Carberry, S. (2012). Updated estimate of trans fat intake by the US population. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 29:861–874.
   PubMed Web of Science ®Google Scholar
• Dubois, V., Breton, S., Linder, M., Fanni, J., and Parmentier, M. (2007). Fatty acid profiles of 80 vegetable oils with regard to their nutritional potential. Eur. J. Lipid Sci. Technol. 109:710–732.
   Google Scholar
• Elwood, P. C., Pickering, J. E., Givens, D. I. and Gallacher, J. E. (2010). The consumption of milk and dairy foods and the incidence of vascular disease and diabetes: An overview of the evidence. Lipids. 10:925–939.
   Web of Science ®Google Scholar
• Enke, U., Jaudszus, A., Schleussner, E., Seyfarth, L., Jahreis, G. and Kuhnt, K. (2011). Fatty acid distribution of cord and maternal blood in human pregnancy: Special focus on individual trans fatty acids and conjugated linoleic acids. Lipids Health Dis. 10:247. December 30, 2011. 10:247. doi: 10.1186/1476-511X-10-247.
   PubMed Web of Science ®Google Scholar
• EU Food Law. (2010). Iceland to introduce trans fat legislation. Available from http://www.eurofoodlaw.com/policy/iceland-to-introduce-trans-fat-legislation–1.htm
   Google Scholar
• European Food Safety Authority (EFSA) (2004). The opinion of the scientific panel on dietetic products, nutrition and allergies on a request from the commission related to the presence of trans-fatty acids in foods and the effect on human health of the consumption of trans fatty acids. EFSA J. 81:1–49.
   Google Scholar
• Federal Ministry of Health Austria (In press). Stöger unterschreibt Transfettsäuren-Verordnung. Available from http://www.ots.at/presseaussendung/OTS_20090820_OTS0082/gesundes-essen-stoeger-unterschreibt-transfettsaeuren-verordnung. Accessed August 20, 2009.
   Google Scholar
• Field, C. J., Blewett, H. H., Proctor, S. and Vine, D. (2009). Human health benefits of vaccenic acid. Appl. Physiol. Nutr. Metab. 34:979–991.
   PubMed Web of Science ®Google Scholar
• Food and Drug Administration (FDA) (2003). Food labeling: Trans fatty acids in nutrition labeling, nutrient content claims, and health claims (21 CFR Part 101). Fed. Regis. 68:41434–41506.
   Google Scholar
• Food Standards Australia New Zealand. (2007). Trans fatty acids in the New Zealand and Australia food supply: Review Report. Food Standards, Australia New Zealand, Canberra/Wellington. Available from http://www.foodstandards.gov.au/newsroom/publications.
   Google Scholar
• Fritsche, J. and Steinhart, H. (1997). Contents of trans fatty acids (TFA) in German foods and estimation of daily intake. Fett-Lipid. 99:314–318.
   Google Scholar
• Gabriel, S. (2009). Ermittlung der Aufnahme von trans-Fettsäuren Durch Lebensmittel in Deutschland. Diploma dissertation. The Federal Institute of Risk Assessment and Friedrich Schiller University Jena, Institute of Nutrition, Jena, Germany.
   Google Scholar
• German, J. B., Gibson, R. A., Krauss, R. M., Nestel, P., Lamarche, B., van Staveren, W. A., Steijns, J. M., de Groot, L., Lock, A. L. and Destaillats, F. (2009). A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk. Eur. J. Nutr. 48:191–203.
   PubMed Web of Science ®Google Scholar
• Gillman, M. W., Cupples, L. A., Gagnon, D., Millen, B. E., Ellison, R. C. and Castelli, W. P. (1997). Margarine intake and subsequent coronary heart disease in men. Epidemiology. 8:144–149.
   PubMed Web of Science ®Google Scholar
• Gómez-Cortés, P., Tyburczy, C., Brenna, J. T., Juárez, M. and de la Fuente, M. A. (2009). Characterization of cis-9 trans-11 trans-15 C18:3 in milk fat by GC and covalent adduct chemical ionization tandem MS. J. Lipid. Res. 50:2412–2420.
   PubMed Web of Science ®Google Scholar
• Health Canada. (2007). Trans fats. Available from http://www.hc-sc.gc.ca/fn-an/nutrition/gras-trans-fats/index-eng.php. Accessed July 20, 2007; last modified December 21, 2009.
   Google Scholar
• Hennessy, A. A., Ross, R. P., Devery, R. and Stanton, C. (2011). The health promoting properties of the conjugated isomers of alpha-linolenic acid. Lipids. 46:105–119.
   PubMed Web of Science ®Google Scholar
• Hilbig, A. (2009). Wie isst Deutschland? Auswertungen der Nationalen Verzehrsstudie II zum Lebensmittelverzehr. Ernahr-Umsch. 56:16–23.
   Google Scholar
• Hodgson, J. M., Wahlqvist, M. L., Boxallc, J. A. and Balazsd, N. D. (1996). Platelet trans fatty acids in relation to angiographically assessed coronary artery disease. Atherosclerosis. 120:147–154.
   PubMed Web of Science ®Google Scholar
• Hu, F. B., Stampfer, M. J., Manson, J. E., Rimm, E., Colditz, G. A., Rosner, B. A., Hennekens, C. H. and Willett, W. C. (1997). Dietary fat intake and the risk of coronary heart disease in women. N. Engl. J. Med. 337:1491–1499.
   PubMed Web of Science ®Google Scholar
• Hulshof, K., van Erp-Baart, M. A., Anttolainen, M., Becker, W., Church, S. M., Couet, C., Hermann-Kunz, E., Kesteloot, H., Leth, T., Martins, I., Moreiras, O., Moschandreas, J., Pizzoferrato, L., Rimestad, A. H., Thorgeirsdottir, H., van Amelsvoort, J. M. M., Aro, A., Kafatos, A. G., Lanzmann-Petithory, D. and van Poppel, G. (1999). Intake of fatty acids in Western Europe with emphasis on trans fatty acids: The TRANSFAIR study. Eur. J. Clin. Nutr. 53:143–157.
   PubMed Web of Science ®Google Scholar
• Jahreis, G., Fritsche, J., Moeckel, P., Schoene, F., Moeller, U. and Steinhart, H. (1999). The potential anticarcinogenic conjugated linoleic acid, cis-9,trans-11 C18:2, in milk of different species: Cow, goat, ewe, sow, mare, woman. Nutr. Res. 19:1541–1549.
   Web of Science ®Google Scholar
• Jahreis, G., Fritsche, J. and Steinhart, H. (1997). Conjugated linoleic acid in milk fat: High variation depending on production system. Nutr. Res. 17:1479–1484.
   Web of Science ®Google Scholar
• Jakobsen, M. U., Bysted, A., Andersen, N. L., Heitmann, B. L., Hartkopp, H. B., Leth, T., Overvad, K. and Dyerberg, J. (2006). Intake of ruminant trans fatty acids in the Danish population aged 1-80 years. Eur. J. Clin. Nutr. 60:312–318.
   PubMed Web of Science ®Google Scholar
• Jakobsen, M. U., Overvad, K., Dyerberg, J. and Heitmann, B. L. (2008). Intake of ruminant trans fatty acids and risk of coronary heart disease. Int. J. Epidemiol. 37:173–182.
   PubMed Web of Science ®Google Scholar
• Jaudszus, A., Jahreis, G., Schloermann, W., Fischer, J., Kramer, R., Degen, C., Rohrer, C., Roth, A., Gabriel, H., Barz, D. and Gruen, M. (2012). Vaccenic acid-mediated reduction in cytokine production is independent of c9,t11-CLA in human peripheral blood mononuclear cells. Biochim. Biophys. Acta. 1821:1316–1322.
   PubMed Web of Science ®Google Scholar
• Judd, J. T. (1994). Dietary trans fatty acids: Effects on plasma lipids and lipoproteins of healthy men and women. Am. J. Clin. Nutr. 59:861–868.
   PubMed Web of Science ®Google Scholar
• Judd, J. T., Baer, D. J., Clevidence, B. A., Kris-Etherton, P., Muesing, R. A. and Iwane, M. (2002). Dietary cis and trans nonounsaturated and saturated FA and plasma lipids and lipoproteins in men. Lipids. 37:123–131.
   PubMed Web of Science ®Google Scholar
• Kadegowda, A. K. G., Connor, E. E., Teter, B. B., Sampugna, J., Delmonte, P., Piperova, L. S. and Erdman, R. A. (2010). Dietary trans fatty acid isomers differ in their effects on mammary lipid metabolism as well as lipogenic gene expression in lactating mice. J. Nutr. 140:919–924.
   PubMed Web of Science ®Google Scholar
• Katan, M. B. (2006). Regulation of trans fats: The gap, the polder, and McDonald's French fries. Atheroscler. Suppl. 7:63–66.
   PubMed Web of Science ®Google Scholar
• Knoll, N., Kuhnt, K., Kyallo, F. M., Kiage-Mokua, B. N. and Jahreis, G. (2011). High content of long-chain n-3 polyunsaturated fatty acids in red blood cells of Kenyan Maasai despite low dietary intake. Lipids Health Dis. August 19, 2011;10:141. doi: 10.1186/1476-511X-10-141.
   PubMed Web of Science ®Google Scholar
• Kraft, J., Collomb, M., Moeckel, P., Sieber, R. and Jahreis, G. (2003). Differences in CLA isomer distribution of cow's milk lipids. Lipids. 38:657–664.
   PubMed Web of Science ®Google Scholar
• Kramer, J. K., Hernandez, M., Cruz-Hernandez, C., Kraft, J. and Dugan, M. E. (2008). Combining results of two GC separations partly achieves determination of all cis and trans 16:1, 18:1, 18:2 and 18:3 except CLA isomers of milk fat as demonstrated using Ag-ion SPE fractionation. Lipids. 43:259–273.
   PubMed Web of Science ®Google Scholar
• Kris-Etherton, P. M., Lefevre, M., Mensink, R. P., Petersen, B., Fleming, J. and Flickinger, B. D. (2012). Trans fatty acid intakes and food sources in the US population: NHANES 1999-2002. Lipids. 47:931–940.
   PubMed Web of Science ®Google Scholar
• Kuhnt, K., Baehr, M., Rohrer, C. and Jahreis, G. (2011). Trans fatty acid isomers and the trans-9/trans-11 index in fat containing foods. Eur. J. Lipid Sci. Technol. 113:1281–1292.
   PubMed Web of Science ®Google Scholar
• Kuhnt, K., Kraft, J., Moeckel, P. and Jahreis, G. (2006). Trans-11-18:1 is effectively Δ9-desaturated compared with trans-12-18:1 in humans. Br. J. Nutr. 95:752–761.
   PubMed Web of Science ®Google Scholar
• Kuhnt, K., Kraft, J., Vogelsang, H., Eder, K., Kratzsch, J. and Jahreis, G. (2007). Dietary supplementation with trans-11- and trans-12-18:1 increases cis-9,trans-11-conjugated linoleic acid in human immune cells, but without effects on biomarkers of immune function and inflammation. Brit. J. Nutr. 95:1196–1205.
   Web of Science ®Google Scholar
• L'Abbé, M. R., Stender, S., Skeaff, M., Ghafoorunissa,   and Tavella, M. (2009). Approaches to removing trans fats from the food supply in industrialized and developing countries. Eur. J. Clin. Nutr. 63:50–67.
   PubMed Web of Science ®Google Scholar
• Lacroix, E., Charest, A., Cyr, A., Baril-Gravel, L., Lebeuf, Y., Paquin, P., Chouinard, P. Y., Couture, P. and Lamarche, B. (2012). Randomized controlled study of the effect of a butter naturally enriched in trans fatty acids on blood lipids in healthy women. Am. J. Clin. Nutr. 95:318–325.
   PubMed Web of Science ®Google Scholar
• Lemaitre, R. N., King, I. B., Mozaffarian, D., Sotoodehnia, N., Rea, T. D., Kuller, L. H., Tracy, R. P. and Siscovick, D. S. (2006). Plasma phospholipid trans fatty acids, fatal ischemic heart disease, and sudden cardiac death in older adults: The cardiovascular health study. Circulation. 114:209–215.
   PubMed Web of Science ®Google Scholar
• Lemaitre, R. N., King, I. B., Raghunathan, T. E., Pearce, R. M., Weinmann, S., Knopp, R. H., Copass, M. K., Cobb, L. A. and Siscovick, D. S. (2002). Cell membrane trans-fatty acids and the risk of primary cardiac arrest. Circulation. 105:697–701.
   PubMed Web of Science ®Google Scholar
• Leth, T., Jensen, H. G., Mikkelsen, A. E. and Bysted, A. (2006). The effect of the regulation on trans fatty acid content in Danish food. Atheroscler. Suppl. 7:53–56.
   PubMed Web of Science ®Google Scholar
• Lichtenstein, A. H. (1998). Trans fatty acids and blood lipid levels, Lp(a), parameters of cholesterol metabolism, and hemostatic factors. J. Nutr. Biochem. 9:244–248.
   Web of Science ®Google Scholar
• Lock, A. L., Corl, B. A., Barbano, D. M., Bauman, D. E. and Ip, C. (2004). The anticarcinogenic effect of trans-11 18:1 is dependent on its conversion to cis-9,trans-11 CLA by Δ9-desaturase in rats. J. Nutr. 134:2698–2704.
   PubMed Web of Science ®Google Scholar
• Lopez-Garcia, E., Schulze, M. B., Meigs, J. B., Manson, J. A. E., Rifai, N., Stampfer, M. J., Willett, W. C. and Hu, F. B. (2005). Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J. Nutr. 135:562–566.
   PubMed Web of Science ®Google Scholar
• Luna, P., Rodriguez-Pino, V. and de la Fuente, M. A. (2009). Occurrence of C16:1 isomers in milk fats from ewes fed with different dietary lipid supplements. Food Chem. 117:248–253.
   Web of Science ®Google Scholar
• Menaa, F., Menaa, A., Tréon, J. and Menaa, B. (2013). Technological approaches to minimize industrial trans fatty acids in foods. J. Food Sci. 78:R377–R386.
   Google Scholar
• Mensink, R. P. and Katan, M. B. (1990). Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. New Engl. J. Med. 323:439–445.
   PubMed Web of Science ®Google Scholar
• Mente, A., de Koning, L., Shannon, H. S. and Anand, S. S. (2009). A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch. Intern. Med. 169:659–669.
   PubMed Web of Science ®Google Scholar
• Molkentin, J. (2009). Authentication of organic milk using delta13C and the alpha-linolenic acid content of milk fat. J. Agric. Food Chem. 57:785–790.
   PubMed Web of Science ®Google Scholar
• Motard-Bélanger, A., Charest, A., Grenier, G., Paquin, P., Chouinard, Y., Lemieux, S., Couture, P. and Lamarche, B. (2008). Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease. Am. J. Clin. Nutr. 87:593–599.
   PubMed Web of Science ®Google Scholar
• Mozaffarian, D., Aro, A. and Willett, W. C. (2009). Health effects of trans-fatty acids: Experimental and observational evidence. Eur. J. Clin. Nutr. 63:5–21.
   PubMed Web of Science ®Google Scholar
• Mozaffarian, D., Cao, H., King, I. B., Lemaitre, R. N., Song, X., Siscovick, D. S. and Hotamisligil, G. S. (2010). Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: A cohort study. Ann. Intern. Med. 153:790–799.
   PubMed Web of Science ®Google Scholar
• Mozaffarian, D., Katan, M. B., Ascherio, A., Stampfer, M. J. and Willett, W. C. (2006). Medical progress - Trans fatty acids and cardiovascular disease. N. Engl. J. Med. 354:1601–1613.
   PubMed Web of Science ®Google Scholar
• Mueller, A., Thijs, C., Rist, L., Simões-Wüst, A. P., Huber, M. and Steinhart, H. (2010). Trans fatty acids in human milk are an indicator of different maternal dietary sources containing trans fatty acids. Lipids. 45:245–251.
   PubMed Web of Science ®Google Scholar
• New York City Department of Health and Mental Hygiene. (2007). The regulation to phase out artificial trans fat In New York City food service establishments. Available from http://www.nyc.gov/html/doh/downloads/pdf/cardio/cardio-transfat-bro.pdf. Accessed November 24, 2015.
   Google Scholar
• Nishida, C. and Uauy, R. (2009). WHO Scientific Update on health consequences of trans fatty acids: Introduction. Eur. J. Clin. Nutr. 63:1–4.
   PubMed Web of Science ®Google Scholar
• Oomen, C. M., Ocké, M. C., Feskens, E. J. M., van Erp-Baart, M. J., Kok, F. J. and Kromhout, D. (2001). Association between trans fatty acid intake and 10-year risk of coronary heart disease in the Zutphen Elderly Study: A prospective population-based study. Lancet. 357:746–751.
   PubMed Web of Science ®Google Scholar
• Özgul-Yücel, S. (2005). Determination of conjugated linolenic acid content of selected oil seeds grown in Turkey. J. AOAC. 82:893–897.
   Google Scholar
• Pariza, M. W., Park, Y. and Cook, M. E. (2001). The biologically active isomers of conjugated linoleic acid. Prog. Lipid. Res. 40:283–298.
   PubMed Web of Science ®Google Scholar
• Parodi, P. W. (2003). Anti-cancer agents in milk fat. Austr. J. Dairy Techn. 58:114–118.
   Web of Science ®Google Scholar
• Pfeuffer, M. and Schrezenmeir, J. (2000). Bioactive substances in milk with properties decreasing risk of cardiovascular diseases. Brit. J. Nutr. 84:155–159.
   PubMed Web of Science ®Google Scholar
• Pfeuffer, M. and Schrezenmeir, J. (2006). Impact of trans fatty acids of ruminant origin compared with those from partially hydrogenated vegetable oils on CHD risk. Int. Dairy J. 16:1383–1388.
   Web of Science ®Google Scholar
• Pietinen, P., Ascherio, A., Korhonen, P., Hartman, A. M., Willett, W. C., Albanes, D., and Virtamo, J. (1997) Intake of fatty acids and risk of coronary heart disease in a cohort of finnish men. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am. J. Epidemiol. 145:876–887.
   PubMed Web of Science ®Google Scholar
• Pintus, S., Murru, E., Carta, G., Cordeddu, L., Batetta, B., Accossu, S., Pistis, D., Uda, S., Ghiani, E. M., Mele, M., Secchiari, P., Almerighi, G., Pintus, P. and Banni, S. (2013). Sheep cheese naturally enriched in α-linolenic, conjugated linoleic and vaccenic acids improves the lipid profile and reduces anandamide in the plasma of hypercholesterolaemic subjects. Br. J. Nutr. 109:1453–1462.
   PubMed Web of Science ®Google Scholar
• Precht, D., Molkentin, J., Destaillats, F. and Wolff, R. L. (2001). Comparative studies on individual isomeric 18:1 acids in cow, goat, and ewe milk fats by low-temperature high-resolution capillary gas–liquid chromatograph. Lipids. 36:827–832.
   PubMed Web of Science ®Google Scholar
• Richter, E. K., Shawish, K. A., Scheeder, M. R. L. and Colombani, P. C. (2009). Trans fatty acid content of selected Swiss foods: The TransSwissPilot Study. J. Food Comp. Anal. 22:479–484.
   Google Scholar
• Roy, A., Chardigny, J. M., Bauchart, D., Ferlay, A., Lorenz, S., Durand, D., Gruffat, D., Faulconnier, Y., Sébédio, J. L. and Chilliard, Y. (2007). Butters rich either in trans-10-C18:1 or in trans-11-C18:1 plus cis-9, trans-11 CLA differentially affect plasma lipids and aortic fatty streak in experimental atherosclerosis in rabbits. Animal. 1:467–476.
   PubMed Web of Science ®Google Scholar
• Schwenke, D. C., Foreyt, J. P., Miller, E. R. 3rd, Reeves, R. S. and Vitolins, M. Z. (2013). Oxidative Stress Subgroup of the Look AHEAD Research Group: Plasma concentrations of trans fatty acids in persons with type 2 diabetes between September 2002 and April 2004. Am. J. Clin. Nutr. 97:862–871.
   PubMed Web of Science ®Google Scholar
• Scrimgeour, C. M. and Harwood, J. L. (2007). Fatty acid and lipid structure. In: The Lipid Handbook. 3rd ed., pp. 6–7. Gunstone, F. D., Harwood, J. L. and Dijkstra, A. J., Eds., CRC Press, Boca Raton, FL.
   Google Scholar
• Shingfield, K. J., Bernard, L., Leroux, C. and Chilliard, Y. (2010). Role of trans fatty acids in the nutritional regulation of mammary lipogenesis in ruminants. Animal. 4:1140–1166.
   PubMed Web of Science ®Google Scholar
• Sklar, L. A., Hudson, B. S. and Simoni, R. D. (1981). Parinaric acid from Parinarium glaberrimum. Methods Enzymol. 72:479–482.
   PubMedGoogle Scholar
• Sofi, F., Buccioni, A., Cesari, F., Gori, A. M., Minieri, S., Mannini, L., Casini, A., Gensini, G. F., Abbate, R. and Antongiovanni, M. (2010). Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inflammatory and haemorheological variables: A dietary intervention study. Nutr. Metab. Cardiovasc. Dis. 20:117–124.
   PubMed Web of Science ®Google Scholar
• Stender, S., Astrup, A. and Dyerberg, J. (2008). Ruminant and industrially produced trans fatty acids: Health aspects. Food Nutr. Res. 52. doi:10.3402/fnr.v52i0.1651. Epub March 12, 2008.
   PubMedGoogle Scholar
• Stender, S., Dyerberg, J., Bysted, A., Leth, T. and Astrup, A. (2006). A trans world journey. Atheroscler. Suppl. 7:47–52.
   PubMed Web of Science ®Google Scholar
• Sun, Q. M. D., Campos, H., Hankinson, S. E., Manson, J. E., Stampfer, M. J., Rexrode, K. M., Willett, W. C. and Hu, F. B. (2007). A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. Circulation. 115:1858–1865.
   PubMed Web of Science ®Google Scholar
• Sundram, K., Ismail, A., Hayes, K. C., Jeyamalar, R. and Pathmanathan, R. (1997). Trans (elaidic) fatty acids adversely affect the lipoprotein profile relative to specific saturated fatty acids in humans. J. Nutr. 127:514–520.
   PubMed Web of Science ®Google Scholar
• Sundram, K., Karupaiah, T. and Hayes, K. C. (2007). Stearic acid-rich interesterified fat and trans-rich fat raise the LDL/HDL ratio and plasma glucose relative to palm olein in humans. Nutr. Metab. (Lond). January 15, 2007; 4:3.
   Google Scholar
• Terpstra, A. H. (2004). Effect of conjugated linoleic acid on body composition and plasma lipids in humans: An overview of the literature. Am. J. Clin. Nutr. 79:352–361.
   PubMed Web of Science ®Google Scholar
• Thijs, C., Müller, A., Rist, L., Kummeling, I., Snijders, B. E., Huber, M., van Ree, R., Simões-Wüst, A. P., Dagnelie, P. C. and van den Brandt, P. A. (2011). Fatty acids in breast milk and development of atopic eczema and allergic sensitisation in infancy. Allergy. 66:58–67.
   PubMed Web of Science ®Google Scholar
• Tholstrup, T., Raff, M., Basu, S., Nonboe, P., Sejrsen, K. and Straarup, E. (2006). Effects of butter high in ruminant trans on lipoproteins, fatty acid incorporation in lipid classes, C-reactive protein, oxidative stress, hemostatic variables and insulin in healthy, young men. Am. J. Clin. Nutr. 83:237–243.
   PubMed Web of Science ®Google Scholar
• Tokede, O. A., Petrone, A. B., Hanson, N. Q., Tsai, M. Y., Weir, N. A., Glynn, R. J., Gaziano, J. M. and Djoussé, L. (2013). Plasma phospholipid trans fatty acids and risk of heart failure. Am. J. Clin. Nutr. 97:698–705.
   PubMed Web of Science ®Google Scholar
• Tricon, S., Burdge, G. C., Jones, E. L., Russell, J. J., El-Khazen, S., Moretti, E., Hall, W. L., Gerry, A. B., Leake, D. S., Grimble, R. F., Williams, C. M., Calder, P. C. and Yaqoob, P. (2006). Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men. Am. J. Clin. Nutr. 83:744–753.
   PubMed Web of Science ®Google Scholar
• Turpeinen, A. M., Mutanen, M. A. A., Salminen, I., Basu, S., Palmquist, D. L. and Griinari, J. M. (2002). Bioconversion of vaccenic acid to conjugated linoleic acid in humans. Am. J. Clin. Nutr. 76:504–510.
   PubMed Web of Science ®Google Scholar
• Valenzuela, A., Nieto, S., Peterson, G. and Tavella, M. (2004). Comparative study in fried food about the stability of different vegetable oils. Fat. Oils Mag. 2:22–28.
   Google Scholar
• Wahle, K. W. J., Heys, S. D. and Rotondo, D. (2004). Conjugated linoleic acids: Are they beneficial or detrimental to health? Prog. Lipid. Res. 43:553–587.
   PubMed Web of Science ®Google Scholar
• Willett, W. C., Stampfer, M. J., Manson, J. E., Colditz, G. A., Speizer, F. E., Rosner, B. A., Sampson, L. A. and Hennekens, C. H. (1993). Intake of trans fatty acids and risk of coronary heart diseases among women. Lancet. 34:1581–1585.
   Google Scholar
• Zock, P. L. and Katan, M. B. (1992). Hydrogenation alternatives: Effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans. J. Lipid. Res. 33:399–410.
   PubMed Web of Science ®Google Scholar