Natural Origin Lycopene and Its “Green” Downstream Processing

REFERENCES

• Abdalla, A. E. M., Darwish, S. M., Ayad, E. H. E. and El-Hamahmy, R. M. (2007). Egyptian mango by-product 2: Antioxidant and antimicrobial activities of extract and oil from mango seed kernel. Food Chem. 103:1141–1152.
   Web of Science ®Google Scholar
• Ajila, C. M., Naidu, K. A., Bhat, S. G. and Prasada Rao, U. J. S. (2007). Bioactive compounds and antioxidant potential of mango peel extract. Food Chem. 105:982–988.
   Web of Science ®Google Scholar
• Amarowicz, R. (2011). Lycopene as a natural antioxidant. Eur. J. Lipid Sci. Technol. 113:675–677.
   Web of Science ®Google Scholar
• Anese, M., Mirolo, G., Beraldo, P. and Lippe, G. (2013). Effect of ultrasound treatments of tomato pulp on microstructure and lycopene in vitro bioaccessibility. Food Chem. 136:458–463.
   PubMed Web of Science ®Google Scholar
• Babler, J. H. and Harvey, W. (2000). Patent WO0031086, C-15 Phosphonate for the manufacture of lycopene.
   Google Scholar
• Bao, Y., Yan, H., Liu, L. and Xu, Q. (2010). Efficient extraction of lycopene from Rhodopseudomonas palustris with n-hexane and methanol after alkaline wash. Chem. Eng. Technol. 33:1665–1671.
   Web of Science ®Google Scholar
• Bart, H. J. and Pilz, S. (2011). Industrial Scale Natural Products Extraction, Wiley-VCH Verlag & Co. KGaA, Weinheim, Germany.
   Google Scholar
• Bautista-Ortín, A. B., Martínez-Cutillas, A., Ros-Garcia, J. M., López-Roca, J. M. and Gómez-Plaza, E. (2005). Improving colour extraction and stability in red wines: the use of maceration enzymes and enological tannins. Int. J. Food Sci. Technol. 40:867–878.
   Web of Science ®Google Scholar
• Bhataya, A., Schmidt-Dannert, C. and Lee, P. C. (2009). Metabolic engineering of Pichia pastoris X-33 for lycopene production. Process Biochem. 44:1095–1102.
   Web of Science ®Google Scholar
• Borguini, R. G. and Torres, E. A. F. D. (2009). Tomatoes and tomato products as dietary sources of antioxidants. Food Rev. Int. 25:313–25.
   Web of Science ®Google Scholar
• Brian, G. (1998). Doing what comes naturally in the dyehouse. J. Soc. Dyers Color. 114:4–7.
   Google Scholar
• Britton, G., Liaaen-Jensen, S. and Pfander, H. (2004). Carotenoids Handbook. Birkhäuser, Basel, Switzerland.
   Google Scholar
• Calvo, M. M., Dado, D. and Santa-Maria, G. (2006). Influence of extraction with ethanol or ethyl acetate on the yield of lycopene, b-carotene, phytoene and phytofluene from tomato peel powder. Eur. Food. Res. Technol. 224:567–571.
   Web of Science ®Google Scholar
• Champagne, C. P. and Fustier, P. (2007). Microencapsulation for the improved delivery of bioactive compounds into foods. Curr. Opin. Biotechnol. 18:184–190.
   PubMed Web of Science ®Google Scholar
• Chan, C. H., Yusoff, R., Ngoh, G. C. and Kung, F. W. L. (2011). Microwave-assisted extractions of active ingredients from plants. J. Chromatogr. A 1218:6213–6225.
   PubMed Web of Science ®Google Scholar
• Chemat, F., Zill-E-Huma,  , Khan, M. K. (2011). Applications of ultrasound in food technology: Processing, preservation and extraction. Ultrason. Sonochem. 18:813–835.
   PubMed Web of Science ®Google Scholar
• Chen, Y., Gu, X., Huang, S. Q., Li, J., Wang, X. and Tang, J. (2010). Optimization of ultrasonic/microwave assisted extraction (UMAE) of polysaccharides from Inonotus obliquus and evaluation of its anti-tumor activities. Int. J. Biol. Macromol. 46:429–435.
   PubMed Web of Science ®Google Scholar
• Choe, E. and Min, D. B. (2009). Mechanisms of antioxidants in the oxidation of foods. Compreh. Rev. Food Sci. Food Saf. 8:345–358.
   Web of Science ®Google Scholar
• Choksi, P. M. and Joshi, V. Y. (2007). A Review on lycopene - extraction, purification, stability and applications. Int. J. Food Proper. 10:289–298.
   Web of Science ®Google Scholar
• Choudhari, S. M. and Ananthanarayan, L., Singhal, R. S. (2008). Use of metabolic stimulators and inhibitors for enhanced production of beta-carotene and lycopene by Blakeslea trispora NRRL 2895 and 2896. Bioresour. Technol. 99:3166–3173.
   PubMed Web of Science ®Google Scholar
• Choudhari, S. M. and Singhal, R. S. (2008). Supercritical carbon dioxide extraction of lycopene from mated cultures of Blakeslea trispora NRRL 2895 and 2896. J. Food. Engineer. 89:349–354.
   Web of Science ®Google Scholar
• Choudhari, S. M. and Ananthanarayan, L. (2007). Enzyme aided extraction of lycopene from tomato tissues. Food Chem. 102:77–81.
   Web of Science ®Google Scholar
• Çinar, I. (2004). Carotenoid pigment loss of freeze-dried plant samples under different storage conditions. LWT - Food Sci. Technol. 37:363–367.
   Google Scholar
• Colle, I. J. P., Lemmens, L., Van Buggenhout, S., Met, K., Van Loey, A. M. and Hendrickx, M. E. (2013). Processing tomato pulp in the presence of lipids: The impact on lycopene bioaccessibility. Food Res. Int. 51:32–38.
   Web of Science ®Google Scholar
• Collins, J. K., Perkins-Veazie, P. and Roberts, W. (2006). Lycopene: From plants to humans. HortScience 41:1135–1144.
   Web of Science ®Google Scholar
• Craft, N. E. and Soares, J. H. (1992). Relative solubility, stability, and absorptivity of lutein and β-carotene in organic solvents. J. Agric. Food Chem. 40:431–434.
   Web of Science ®Google Scholar
• Cravotto, G., Boffa, L., Mantegna, S., Perego, P., Avogadro, M. and Cintas, P. (2008). Improved extraction of vegetable oils under high-intensity ultrasound and/or microwaves. Ultrason. Sonochem. 15:898–902.
   PubMed Web of Science ®Google Scholar
• De la Fuente, J. C., Oyarzun, B., Quezada, N. and Del Valle, J. M. (2006). Solubility of carotenoid pigments (lycopene and astaxanthin) in supercritical carbon dioxide. Fluid Phase Equilib. 247:90–95.
   Web of Science ®Google Scholar
• de Lorenzo, V. (2008). Systems biology approaches to bioremediation. Curr. Opin. Biotechnol. 19:579–589.
   PubMed Web of Science ®Google Scholar
• Dehghan-Shoar, Z., Hardacre, A. K., Meerdink, G. and Brennan, C. S. (2011). Lycopene extraction from extruded products containing tomato skin. Int. J. Food Sci. Technol. 46:365–371.
   Web of Science ®Google Scholar
• Dolatowski, Z. J., Stadnik, J. and Stasiak, D. (2007). Applications of ultrasound in food technology. Acta Sci. Pol. Technol. Aliment. 6:89–99.
   Google Scholar
• dos Anjos Ferreira, A. L., Yeum, K. J., Russell, R. M., Krinsky, N. I. and Tang, G. (2004). Enzymatic and oxidative metabolites of lycopene. J. Nutr. Biochem. 15:493–502.
   PubMed Web of Science ®Google Scholar
• Echaverri-Erasum, C., Johnson, E. A. (2002). Fungal carotenoids. In: Applied mycology and biotechnology. Khachatourians G. G., Arora D. K., eds., pp. 45–87. Elsevier, Amsterdam.
   Google Scholar
• Edge, R., McGarvey, D. J. and Truscott, T. G. (1997). The carotenoids as anti-oxidants—A review. J. Photochem. Photobiol. B 41:189–200.
   PubMed Web of Science ®Google Scholar
• Eh, A. L. S. and Teoh, S. G. (2012). Novel modified ultrasonication technique for the extraction of lycopene from tomatoes. Ultrason. Sonochem. 19:151–159.
   PubMed Web of Science ®Google Scholar
• Ernst, H. (2002). Recent advances in industrial carotenoid synthesis. Pure Appl. Chem. 74:1369–1382.
   Web of Science ®Google Scholar
• Farmer, W. R. and Liao, J. C. (2000). Improving lycopene production in Escherichia coli by engineering metabolic control. Nat. Biotechnol. 18:533–537.
   PubMed Web of Science ®Google Scholar
• Fish, W. W., Perkins-Veazie, P. and Collins, J. K. (2002). A quantitative assay for lycopene that utilizes reduced volumes of organic solvents. J. Food Comp. Anal. 15:309–317.
   Web of Science ®Google Scholar
• Fish, W. W. (2006). Interaction of sodium dodecyl sulfate with watermelon chromoplasts and examination of the organization of lycopene within the chromoplasts. J. Agric. Food Chem. 54:8294–8300.
   PubMed Web of Science ®Google Scholar
• Garrido, M., Gonzalez-Flores, D., Marchena, A. M., Prior, E., Garcıa-Parra, J., Barriga, C. and Rodrıguez Moratinos, A. B. (2013). A lycopene-enriched virgin olive oil enhances antioxidant status in humans. J. Sci. Food Agric.. 93:1820–1826.
   PubMed Web of Science ®Google Scholar
• Garrido, M., González-Flores, D., Marchena, A. M., Prior, E., García-Parra, J., Barriga, C. and Rodríguez Moratinos, A. B. (2012). A lycopene-enriched virgin olive oil enhances antioxidant status in humans. J. Sci. Food Agric. Article in Press
   Web of Science ®Google Scholar
• Gomez-Prieto, M. S., Caja, M. M., Herraiz, M. and Santa-Maria, G. (2003). Supercritical fluid extraction of all-trans-lycopene from tomato. J. Agric. Food Chem. 51:3–7.
   PubMed Web of Science ®Google Scholar
• Gomez-Prieto, M. S., Caja, M. M. and Santa-Maria, G. (2002). Solubility in supercritical carbon dioxide of the predominant carotenes of tomato skin. J. Am. Oil Chem. Soc. 79:897–902.
   Web of Science ®Google Scholar
• Haber, D. and Lu, Q. Y. (2002). Overview of mechanism of action of lycopene. Exp. Biol. Med. 227:920–923.
   Web of Science ®Google Scholar
• Hathcock, J. and Kriengsinyos, W. (2011). Highest Observed Intake: Definition, regulatory uses and provisional values. Regulat. Toxicol. Pharmacol. 61:115–118.
   PubMed Web of Science ®Google Scholar
• Huang, W., Li, Z., Niu, H., Li, D. and Zhang, J. (2008). Optimization of operating parameters for supercritical carbon dioxide extraction of lycopene by response surface methodology. J. Food Eng. 89:298–302.
   Web of Science ®Google Scholar
• Ishida, B. K. and Bartley, G. E. (2005). Carotenoids: chemistry, sources, and physiology. In: Encyclopedia of Human Nutrition, pp 330–338. Caballero, B., Allen, L., Prentice, A., 2nd ed., Eds., Elsevier, Oxford, U.K.
   Google Scholar
• Ishida, B. K. and Chapman, M. H. (2009). Carotenoid extraction from plants using a novel, environmentally friendly solvent. J. Agric. Food Chem. 57:1051–1059.
   PubMed Web of Science ®Google Scholar
• Ishida, B. K. and Chapman, M. H. (2012). Effects of a hydrodynamic process on extraction of carotenoids from tomato. Food Chem. 132:1156–1160.
   Web of Science ®Google Scholar
• Isler, O. (1971). Carotenoids. Birkhauserverlag, Basel, Switzerland.
   Google Scholar
• Jaswir, I., Noviendri, D., Hasrini, R. F. and Octavianti, F. (2011). Carotenoids: Sources, medicinal properties and their application in food and nutraceutical industry. J. Med. Plants Res. 5:7119–7131.
   Web of Science ®Google Scholar
• Jin, Y. S. and Stephanopoulos, G. (2007). Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli. Metab. Eng. 9:337–347.
   PubMed Web of Science ®Google Scholar
• Jonker, D., Kuper, C., Fraile, N., Estrella, A. and Rodriguez, O. (2003). Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats. Regul. Toxicol. Pharmacol. 37:396–406.
   PubMed Web of Science ®Google Scholar
• Kanjilal, P. B. and Singh, R. S. (1995). Agronomic evaluation of annatto (Bixa orellana L.). J. Herbs Spices Medic. Plants 3:13–17.
   Google Scholar
• Kaur, A., Dhari, J., Sharma, O. P., Gupta, G. D. and Kharb, V. (2011). Lycopene. Inter. J. Pharm. Technol. 3:1605–1622.
   Google Scholar
• Kaur, D., Wani, A. A., Oberoi, D. P. S. and Sogi, D. S. (2008). Effect of extraction conditions on lycopene extractions from tomato processing waste skin using response surface methodology. Food Chem. 108:711–718.
   PubMed Web of Science ®Google Scholar
• Kelkel, M., Schumacher, M., Dicato, M. and Diederich, M. (2011). Antioxidant and anti-proliferative properties of lycopene. Free Rad. Res. 45:925–940.
   PubMed Web of Science ®Google Scholar
• Khachik, F., Carvallo, L., Bernstein, P. S., Muir, G. J., Zhao, D. Y. and Katz, N. B. (2002). Chemistry, distribution and metabolism of tomato carotenoids and their impact on human health. Exp. Biol. Med. (Maywood) 227:845–851.
   PubMed Web of Science ®Google Scholar
• Khatoon, S. and Shome, U. (1993). Analysis of commercial ‘Ratanj’ of by TLC fluorescence fingerprinting. Int. J. Pharmacogn. 31:269–277.
   Google Scholar
• Kim, S. W., Kim, J. B., Ryu, J. M., Jung, J. K. and Kim, J. H. (2009). High-level production of lycopene in metabolically engineered E. coli. Process Biochem. 44:899–905.
   Web of Science ®Google Scholar
• Kim, Y. S., Lee, J. H., Kim, N. H., Yeom, S. J., Kim, S. W. and Oh, D. K. (2011). Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli. Appl. Microbiol. Biotechnol. 90:489–497.
   PubMed Web of Science ®Google Scholar
• Klein-Marcuschamer, D., Ajikumar, P. K. and Stephanopoulos, G. (2007). Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene. Trend Biotechnol. 25:417–424.
   PubMed Web of Science ®Google Scholar
• Kong, K. W., Khoo, H. E., Prasad, K. N., Ismail, A., Tan, C. P. and Rajab, N. F. (2010). Revealing the power of the natural red pigment lycopene. Molecules 15:959–987.
   PubMed Web of Science ®Google Scholar
• Konwarh, R., Pramanik, S., Kalita, D., Mahanta, C. L. and Karak, N. (2012). Ultrasonication—A complementary ‘green chemistry’ tool to biocatalysis: A laboratory-scale study of lycopene extraction. Ultrason. Sonochem. 19:292–299.
   PubMed Web of Science ®Google Scholar
• Kubola, J. and Siriamornpun, S. (2011). Phytochemicals and antioxidant activity of different fruit fractions (peel, pulp, aril and seed) of Thai gac (Momordica cochinchinensis Spreng). Food Chem. 127:1138–1145
   PubMed Web of Science ®Google Scholar
• Kumcuoglu, S., Yilmaz, T. and Tavman, S. (2014). Ultrasound assisted extraction of lycopene from tomato processing wastes, J. Food Sci. Technol. 51:4102–4107.
   PubMed Web of Science ®Google Scholar
• Kumar, J. K. and Sinha, A. K. (2004). Resurgence of natural colourants: a holistic view. Nat. Prod. Res. 18:59–84.
   PubMed Web of Science ®Google Scholar
• Kumcuoglu, S., Yilmaz, T. and Tavman, S. (2013). Ultrasound assisted extraction of lycopene from tomato processing wastes, J. Food Sci. Technol. Article in Press, 1–6. DOI: 10.1007/s13197-013-0926-x.
   PubMed Web of Science ®Google Scholar
• Landbo, A. K. and Meyer, A. S. (2001). Enzyme-assisted extraction of antioxidative phenols from black currant juice press residues (Ribes nigrum). J. Agric. Food Chem. 49:3169–3177.
   PubMed Web of Science ®Google Scholar
• Laufenberg, G., Kunz, B. and Nystroem, M. (2003). Transformation of vegetable waste into value added products: (A) the upgrading concept; (B) practical implementations. Biores. Technol. 87:167–198.
   PubMed Web of Science ®Google Scholar
• Lee, J. W., Kim, T. Y., Jang, Y. S., Choi, S. and Lee, S. Y. (2011). Systems metabolic engineering for chemicals and materials. Trend Biotechnol. 29:370–378.
   PubMed Web of Science ®Google Scholar
• Lenucci, M. S., Caccioppola, A., Durante, M., Serrone, L., Leonardo, R., Piro, G. and Dalessandro, G. (2010). Optimisation of biological and physical parameters for lycopene supercritical CO2 extraction from ordinary and high-pigment tomato cultivars. J. Sci. Food Agric. 90:1709–1718.
   PubMed Web of Science ®Google Scholar
• Lianfu, Z. and Zelong, L. (2008). Optimization and comparison of ultrasound/microwave assisted extraction (UMAE) and ultrasonic assisted extraction (UAE) of lycopene from tomatoes. Ultrason. Sonochem. 15:731–737.
   PubMed Web of Science ®Google Scholar
• Lin, C. H. and Chen, B. H. (2003). Determination of carotenoids in tomato juice by liquid chromatography. J. Chromatogr. A 1012:103–109.
   PubMed Web of Science ®Google Scholar
• Liu, Y., Liu, J., Chen, X., Liu, Y. and Di, D. (2010). Preparative separation and purification of lycopene from tomato skins extracts by macroporous adsorption resins. Food Chem. 123:1027–1034.
   Web of Science ®Google Scholar
• Lopez-Nieto, M., Costa, J., Peiro, E., Méndez, E., Rodriguez-Sálz, M., de la Fuente, J. L., Cabri, W. and Barredo, J. L. (2004). Biotechnological lycopene production by mated fermentation of Blakeslea trispora. Appl. Microbiol. Biotechnol. 66:153–159.
   PubMed Web of Science ®Google Scholar
• Machmudah, S., Zakaria  , Winardi, S., Sasaki, M., Goto, M., Kusumoto, N. and Hayakawa, K. (2012). Lycopene extraction from tomato peel by-product containing tomato seed using supercritical carbon dioxide. J. Food Eng. 108:290–296.
   Web of Science ®Google Scholar
• Maiani, G., Castón, M. J. P., Catasta, G., Toti, E., Cambrodón, I. G., Bysted, A., Granado-Lorencio, F., Olmedilla-Alonso, B., Knuthsen, P., Valoti, M., Böhm, V., Mayer-Miebach, E., Behsnilian, D. and Schlemmer, U. (2009). Carotenoids: Actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans. Mol. Nutr. Food Res. 53:S194–S218.
   PubMed Web of Science ®Google Scholar
• Matulka, R., Hood, A. and Griffths, J. (2004). Safety evaluation of a natural tomato oleoresin extract derived from food-processing tomatoes. Regul. Toxicol. Pharmacol. 39:390–402.
   PubMed Web of Science ®Google Scholar
• McClain, R. and Bausch, J. (2003). Summary of safety studies conducted with synthetic lycopene. Regul. Pharmacol. Toxicol. 37:274–285.
   PubMed Web of Science ®Google Scholar
• Mein, J. R., Lian, F. and Wang, X. D. (2008). Biological activity of lycopene metabolites: Implications for cancer prevention. Nutr. Rev. 66:667–683.
   PubMed Web of Science ®Google Scholar
• Mellert, W., Deckardt, K., Gembardt, C., Schulte, S. and Van Ravenzwaay, B. (2002). Thirteen-week oral toxicity study of synthetic lycopene products in rats. Food Chem. Toxicol. 40:1581–1588.
   PubMed Web of Science ®Google Scholar
• Montesano, D., Fallarino, F., Cossignani, L., Bosi, A., Simonetti, M. S., Puccetti, P. and Damiani, P. (2008). Innovative extraction procedure for obtaining high pure lycopene from tomato. Europ. Food Res. Technol. 226:327–335.
   Web of Science ®Google Scholar
• Nagao, A. (2004). Oxidative conversion of carotenoids to retinoids and other products. J. Nutr. 134:S237–S240.
   PubMed Web of Science ®Google Scholar
• Namitha, K. K. and Negi, P. S. (2010). Chemistry and Biotechnology of Carotenoids. Crit. Rev. Food. Sci. Nutr. 50:728–760.
   PubMed Web of Science ®Google Scholar
• Naviglio, D., Pizzolongo, F., Ferrara, L., Aragòn, A. and Santini, A. (2008). Extraction of pure lycopene from industrial tomato by-products in water using a new high-pressure process. J. Sci. Food Agricult. 88:2414–2420.
   Web of Science ®Google Scholar
• Nhung, D. T. T., Bung, P. N., Ha, N. T. and Phong, T. K. (2010). Changes in lycopene and beta carotene contents in aril and oil of gac fruit during storage. Food Chem 121:326–331.
   Web of Science ®Google Scholar
• Nobre, B. P., Gouveia, L., Matos, P. G. S., Cristino, A. F., Palavra, A. F. and Mendes, R. L. (2012). Supercritical extraction of lycopene from tomato industrial wastes with ethane. Molecules 17: 8397–8407.
   PubMed Web of Science ®Google Scholar
• Olives Barba, A. I., Cámara Hurtado, M., Sánchez Mata, M. C., Fernández Ruiz, V. and López Sáenz de Tejada, M. (2006). Application of a UV-Vis detection-HPLC method for a rapid determination of lycopene and β-carotene in vegetables. Food Chem. 95:328–336.
   Web of Science ®Google Scholar
• Olson, J. A. (1994). Absorption, transport, and metabolism of carotenoids in humans. Pure Appl. Chem. 66:1011–1016.
   Web of Science ®Google Scholar
• Page, D., Van Stratum, E., Degrou, A. and Renard, C. M. G. C. (2012). Kinetics of temperature increase during tomato processing modulate the bioaccessibility of lycopene. Food Chem. 135:2462–2469.
   PubMed Web of Science ®Google Scholar
• Papaioannou, E. H. and Liakopoulou-Kyriakides, M. (2012). Agro-food wastes utilization by Blakeslea trispora for carotenoids production. Acta Bioch. Polon. 59:151–153.
   PubMed Web of Science ®Google Scholar
• Papaioannou, E., Roukas, T. and Liakopoulou-Kyriakides, M. (2008). Effect of biomass pre-treatment and solvent extraction on β-carotene and lycopene recovery from Blakeslea trispora cells. Prepar. Biochem. Biotechn. 38:246–256.
   PubMed Web of Science ®Google Scholar
• Papaioannou, E. H. and Karabelas, A. J. (2012). Tomato peel lycopene recovery under mild conditions assisted by enzymatic pre-treatment and non-ionic surfactants. Acta Biochim. Polon. 59:71–74.
   PubMed Web of Science ®Google Scholar
• Papaioannou, E. H. and Liakopoulou- Kyriakides, M. (2010). Substrate contribution on carotenoids production in Blakeslea trispora cultivations. Food Bioprod. Proces. 88:305–311.
   Web of Science ®Google Scholar
• Papaioannou, E. H., Stoforos, N. and Liakopoulou-Kyriakides, M. (2011). Substrate contribution on free radical scavenging capacity of carotenoid extracts produced from Blakeslea trispora cultures. World J. Microbiol. Biotechnol. 27:851–858.
   Web of Science ®Google Scholar
• Periago, M. J., Rincón, F., Agüera, M. D. and Ros, G. (2004). Mixture approach for optimizing lycopene extraction from tomato and tomato products. J. Agricult. Food Chem. 52:5796–5802.
   PubMed Web of Science ®Google Scholar
• Perkins-Veazie, P., Collins, J. K., Davis, A. R. and Roberts, W. (2006). Carotenoid content of 50 watermelon cultivars. Agric. Food Chem. 54:2593–2597.
   PubMed Web of Science ®Google Scholar
• Perkins-Veazie, P., Collins, J. K., Pair, S. D. and Roberts, W. (2001). Lycopene content differs among red-fleshed watermelon cultivars. J. Sci. Food. Agric. 81:983–987.
   Web of Science ®Google Scholar
• Preedy, V. R. and Watson, R. R. (2008). Lycopene Nutritional, Medicinal and Therapeutic Properties. Science Publishers, Enfield, NH, USA.
   Google Scholar
• Puri, M., Sharma, D. and Barrow, C. J. (2012). Enzyme-assisted extraction of bioactives from plants. Trend Biotechnol. 30:37–44.
   PubMed Web of Science ®Google Scholar
• Qui, W., Jiang, H., Wang, H. and Gao, Y. (2006). Effect of high hydrostatic pressure on lycopene stability. Food Chem. 97:516–523.
   Web of Science ®Google Scholar
• Ranveer, R. C., Patil, S. N., Sahoo, A. K. (2013). Effect of different parameters on enzyme-assisted extraction of lycopene from tomato processing waste. Food Bioprod. Process. 91:370–375.
   Web of Science ®Google Scholar
• Ranveer, R. C., Patil, S. N. and Sahoo, A. K. (2013). Effect of different parameters on enzyme-assisted extraction of lycopene from tomato processing waste. Food Bioprod. Process. Article in Press, 1–6. DOI: 10.1016/j.fbp.2013.01.006
   Web of Science ®Google Scholar
• Rao, A. V., Raym, M. R. and Rao, L. G. (2006). Lycopene. Adv. Food Nutr. Res. 51:99–164.
   PubMedGoogle Scholar
• Rastogi, N. K. (2011). Opportunities and challenges in application of ultrasound in food processing. Crit. Rev. Food Sci. Nutr. 51:705–722.
   PubMed Web of Science ®Google Scholar
• Rozzi, N. L., Singh, R. K., Vierling, R. A. and Watkins, B. A. (2002). Supercritical fluid extraction of lycopene from tomato processing byproducts. J. Agric. Food Chem. 50:2638–2643.
   PubMed Web of Science ®Google Scholar
• Saldaña, M. D. A., Temelli, F., Guigard, S. E., Tomberli, B. and Gray, C. G. (2010). Apparent solubility of lycopene and b-carotene in supercritical CO2, CO2 + ethanol and CO2 + canola oil using dynamic extraction of tomatoes. J. Food Eng. 99:1–8.
   Web of Science ®Google Scholar
• Schmidt-Dannert, C. (2000). Engineering novel carotenoids in microorganisms. Curr. Opin. Biotechnol. 11:255–261.
   PubMed Web of Science ®Google Scholar
• Schweiggert, R. M., Mezger, D., Schimpf, F., Steingass, C. B. and Carle, R. (2012). Influence of chromoplast morphology on carotenoid bioaccessibility of carrot, mango, papaya, and tomato. Food Chem. 135:2736–2742.
   PubMed Web of Science ®Google Scholar
• Shah, N. C. (1997). Traditional uses of Turmeric (Curcuma longa) in India. J. Med. Arom. Plant Sci. 19:948–954.
   Google Scholar
• Shen, R., Jiang, X., Ye, W., Song, X., Liu, L., Lao, X. and Wu, C. (2011). A novel and practical synthetic route for the total synthesis of lycopene. Tetrahedron 67:5610–5614.
   Web of Science ®Google Scholar
• Shi, J., Khatri, M., Xue, S. J., Mittal, G. S., Ma, Y. and Li, D. (2009a). Solubility of lycopene in supercritical CO2 fluid as affected by temperature and pressure. Sep. Purif. Technol. 66:322–328.
   Web of Science ®Google Scholar
• Shi, J. and Le Maguer, M. (2000). Lycopene in tomatoes: Chemical and physical properties affected by food processing. Crit. Rev. Food Sci. Nutr. 40:1–42.
   PubMed Web of Science ®Google Scholar
• Shi, J., Yi, C., Xue, S. J., Jiang, Y., Ma, Y. and Li, D. (2009b). Effects of modifiers on the profile of lycopene extracted from tomato skins by supercritical CO2. J. Food Eng. 93:431–436.
   Web of Science ®Google Scholar
• Shi, X., Xu, Y., Li, Y., Zeng, H. and Sun, Y. (2012a). Optimization of extraction process of lycopene from Watermelon (Citrullus lanatus) by response surface methodology. Appl. Mechan. Mater. 140:385–393.
   Google Scholar
• Shi, Y. Q., Xin, X. L. and Yuan, Q. P. (2012b). Improved lycopene production by Blakeslea trispora with isopentenyl compounds and metabolic precursors. Biotechnol. Let. 34:849–852.
   PubMed Web of Science ®Google Scholar
• Spernath, A., Yaghmur, A., Aserin, A., Hoffman, R. E. and Garti, N. (2002). Food-grade microemulsions based on nonionic emulsifiers: Media to enhance lycopene solubilization. J. Agric. Food Chem. 50:6917–6922.
   PubMed Web of Science ®Google Scholar
• Strati, I. F. and Oreopoulou, V. (2011a). Effect of extraction parameters on the carotenoid recovery from tomato waste. Inter. J. Food Sci. Technol. 46:23–29.
   Web of Science ®Google Scholar
• Strati, I. F. and Oreopoulou, V. (2011b). Process optimisation for recovery of carotenoids from tomato waste. Food Chem. 129:747–752.
   PubMed Web of Science ®Google Scholar
• Tarazona-Díaz, M. P., Viegas, J., Moldao-Martinsc, M. and Aguayo, E. (2011). Bioactive compounds from flesh and by-product of fresh-cut watermelon cultivars. J. Sci. Food Agric. 91:805–812.
   PubMed Web of Science ®Google Scholar
• Tello, J., Viguera, M. and Calvo, L. (2011). Extraction of caffeine from Robusta coffee (Coffea canephora var. Robusta) husks using supercritical carbon dioxide. J. Supercr. Fluids 59:53–60.
   Web of Science ®Google Scholar
• Tereshina, V. M., Memorskaya, A. S. and Feofilova, E. P. (2010). Lipid composition of the mucoraceous fungus Blakeslea trispora under lycopene formation-stimulating conditions. Microbiology 79:34–39
   Web of Science ®Google Scholar
• Topal, U., Sasaki, M., Goto, M. and Hayakawa, K. (2006). Extraction of lycopene from tomato skin with supercritical carbon dioxide: effect of operating conditions and solubility analysis. J. Agric. Food Chem. 54:5604–5610.
   PubMed Web of Science ®Google Scholar
• Toprak Aktas, E. and Yildiz, H. (2011). Effects of electroplasmolysıs treatment on chlorophyll and carotenoıd extractıon yıeld from spinach and tomato. J. Food Eng. 106:339–346.
   Web of Science ®Google Scholar
• Tucker, G. (2003). Nutritional enhancement of plants. Curr. Opin. Biotechnol. 14:221–225
   PubMed Web of Science ®Google Scholar
• Vagi, E., Simandi, B., Vasarhelyine, K. P., Daood, H., Kery, A., Doleschall, F. and Nagy, B. (2007). Supercritical carbon dioxide extraction of carotenoids, tocopherols and sitosterols from industrial tomato by-products. J. Supercrit. Fluids. 40:218–226.
   Web of Science ®Google Scholar
• Varona, S., Braeuer, A., Leipertz, A., Martín, Á. and Cocero, M. J. (2013). Lycopene solubility in mixtures of carbon dioxide and ethyl acetate. J. Supercrit. Fluids 75:6–10.
   Web of Science ®Google Scholar
• Vasapollo, G., Longo, L., Rescio, L. and Ciurlia, L. (2004). Innovative supercritical CO2 extraction of lycopene from tomato in the presence of vegetable oil as co-solvent. J. Supercr. Fluids 29:87–96.
   Web of Science ®Google Scholar
• Vaughn Katherine, L. S., Clausen Edgar, C., King Jerry, W., Howard Luke, R. and Julie, C. D. (2008). Extraction conditions affecting supercritical fluid extraction (SFE) of lycopene from watermelon. Bioresour. Technol. 99:7835–7841.
   PubMed Web of Science ®Google Scholar
• Vogele, A. C. (1937). Effect of environmental factors upon the color of the tomato and the watermelon. Plant Physiol. 12:929–955.
   PubMedGoogle Scholar
• Vuong, L. T., Franke, A. A., Custer, L. J. and Murphy, S. P. (2006). Momordica cochinchinensis Spreng. (gac) fruit carotenoids reevaluated. J. Food Comp. Anal. 19:664–668.
   Web of Science ®Google Scholar
• Wang, J. F., Liu, X. J., Liu, R. S., Li, H. M. and Tang, Y. J. (2011). Optimization of the mated fermentation process for the production of lycopene by Blakeslea trispora NRRL 2895 (+) and NRRL 2896 (−). Bioproc. Biosyst. Engin. 35:553–564.
   PubMed Web of Science ®Google Scholar
• Wang, Y., Zhang, M. and Hu, Y. (2010). Foam fractionation of lycopene: An undergraduate chemistry experiment. J. Chem. Educ. 87:510–511
   Web of Science ®Google Scholar
• Xi, J. (2006). Effect of high pressure processing on the extraction of lycopene in tomato paste waste. Chem. Eng. Technol. 29:736–739.
   Web of Science ®Google Scholar
• Xianquan, S., Shi, J., Kakuda, Y. and Yueming, J. (2005). Stability of lycopene during food processing and storage. J. Med. Food 8:413–422.
   PubMed Web of Science ®Google Scholar
• Yonekura, L. and Nagao, A. (2007). Intestinal absorption of dietary carotenoids. Mol. Nutr. Food Res. 51:107–115.
   PubMed Web of Science ®Google Scholar
• Zhang, L. and Liu, Z. (2008). Optimization and comparison of ultrasound/ microwave assisted extraction (UMAE) and ultrasonic assisted extraction (UAE) of lycopene from tomatoes. Ultrason. Sonochem. 15:731–737.
   PubMed Web of Science ®Google Scholar
• Zhu, J., Zhang, M. and Liu, Q. (2010). Interdisciplinary chemistry experiment: An environmentally friendly extraction of lycopene. J. Chem. Educ. 85:256–257.
   Web of Science ®Google Scholar
• Zollinger, H. (1991). Color Chemistry: Synthetic, Properties and Applications of Organic Dyes and Pigments. 2nd Edn., VCH, Weinheim, Germany, p. 52.
   Google Scholar
• Zuorro, A., Lavecchia, R., Medici, F. and Piga, L. (2013). Enzyme-Assisted production of tomato seed oil enriched with lycopene from tomato pomace. Food Bioprocess Technol. 6:3499–3509.
   Web of Science ®Google Scholar
• Zuorro, A. and Lavecchia, R. (2010). Mild enzymatic method for the extraction of lycopene from tomato paste. Biotechnol. Biotechnolog. Equipment. 24:1854–1857.
   Web of Science ®Google Scholar
• Zuorro, A., Fidaleo, M. and Lavecchia, R. (2011). Enzyme-assisted extraction of lycopene from tomato processing waste. Enzyme Microb. Technol. 49:567–573.
   PubMed Web of Science ®Google Scholar
• Zuorro, A., Lavecchia, R., Medici, F. and Piga, L. (2012). Enzyme-Assisted production of tomato seed oil enriched with lycopene from tomato pomace. Food Bioprocess Technol. Article in Press, 1–11. DOI: 10.1007/s11947-012-1003-6
   Web of Science ®Google Scholar