Long-chain n-3 PUFA against breast and prostate cancer: Which are the appropriate doses for intervention studies in animals and humans?

References

• Abou-el-Ela, S. H., Prasse, K. W., Carroll, R., Wade, A. E., Dharwadkar, S. and Bunce, O. R. (1988). Eicosanoid synthesis in 7,12-dimethylbenz(a)anthracene-induced mammary carcinomas in Sprague-Dawley rats fed primrose oil, menhaden oil or corn oil diet. Lipids 23:948–954.
   PubMed Web of Science ®Google Scholar
• Abou-el-Ela, S. H., Prasse, K. W., Farrell, R. L., Carroll, R. W., Wade, A. E. and Bunce, O. R. (1989). Effects of D,L-2-difluoromethylornithine and indomethacin on mammary tumor promotion in rats fed high n-3 and/or n-6 fat diets. Cancer Res. 49:1434–1440.
   PubMed Web of Science ®Google Scholar
• Akinsete, J. A., Ion, G., Witte, T. R. and Hardman, W. E. (2012). Consumption of high ω-3 fatty acid diet suppressed prostate tumorigenesis in C3(1) Tag mice. Carcinogenesis 33:140–148.
   PubMed Web of Science ®Google Scholar
• Anti, M., Armelao, F., Marra, G., Percesepe, A., Bartoli, G. M., Palozza, P., Parrella, P., Canetta, C., Gentiloni, N., De Vitis, I., et al. (1994). Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. Gastroenterology 107:1709–1718.
   PubMed Web of Science ®Google Scholar
• Aronson, W. J., Kobayashi, N., Barnard, R. J., Henning, S., Huang, M., Jardack, P. M., Liu, B., Gray, A., Wan, J., Konijeti, R., Freedland, S. J., Castor, B., Heber, D., Elashoff, D., Said, J., Cohen, P. and Galet, C. (2011). Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy. Cancer Prev. Res. (Phila). 4:2062–2071.
   PubMed Web of Science ®Google Scholar
• Arterburn, L. M., Hall, E. B. and Oken, H. (2006). Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am. J. Clin. Nutr. 83:1467S–1476S.
   PubMed Web of Science ®Google Scholar
• Berquin, I. M., Min, Y., Wu, R., Wu, J., Perry, D., Cline, J. M., Thomas, M. J., Thornburg, T., Kulik, G., Smith, A., Edwards, I. J., D'Agostino, R., Zhang, H., Wu, H., Kang, J. X. and Chen, Y. Q. (2007). Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J. Clin. Invest. 117:1866–1875.
   PubMed Web of Science ®Google Scholar
• Blank, E. W. and Cerian, R. L. (1989). Fish oil enhancement of 131I-conjugated anti-human milk fat globule monoclonal antibody experimental radioimmunotherapy of breast cancer. J. Steroid. Biochem. 34:149–153.
   PubMedGoogle Scholar
• Blasbalg, T. L., Hibbeln, J. R., Ramsden, C. E., Majchrzak, S. F. and Rawlings, R. R. (2011). Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am. J. Clin. Nutr. 93:950–962.
   PubMed Web of Science ®Google Scholar
• Blonk, M. C., Bilo, H. J., Nauta, J. J., Popp-Snijders, C., Mulder, C. and Donker, A. J. (1990). Dose–response effects of fish-oil supplementation in healthy volunteers. Am. J. Clin. Nutr. 52:120–127.
   PubMed Web of Science ®Google Scholar
• Borgeson, C. E., Pardini, L., Pardini, R. S. and Reitz, R. C. (1989). Effects of dietary fish oil on human mammary carcinoma and on lipid-metabolizing enzymes. Lipids 24:290–295.
   PubMed Web of Science ®Google Scholar
• Bougnoux, P., Hajjaji, N., Ferrasson, M. N., Giraudeau, B., Couet, C. and Le Floch, O. (2009). Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: A phase II trial. Br. J. Cancer 101:1978–1985.
   PubMed Web of Science ®Google Scholar
• Braden, L. M. and Carroll, K. K. (1986). Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats. Lipids 21:285–288.
   PubMed Web of Science ®Google Scholar
• Brasky, T. M., Darke, A. K., Song, X., Tangen, C. M., Goodman, P. J., Thompson, I. M., Meyskens, F. L. Jr, Goodman, G. E., Minasian, L. M., Parnes, H. L., Klein, E. A. and Kristal, A. R. (2013). Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial. J. Natl. Cancer Inst. 105:1132–1141.
   PubMed Web of Science ®Google Scholar
• Calviello, G., Di Nicuolo, F., Gragnoli, S., Piccioni, E., Serini, S., Maggiano, N., Tringali, G., Navarra, P., Ranelletti, F. O. and Palozza, P. (2004). n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. Carcinogenesis 25:2303–2310.
   PubMed Web of Science ®Google Scholar
• Calviello, G., Di Nicuolo, F., Serini, S., Piccioni, E., Boninsegna, A., Maggiano, N., Ranelletti, F. O. and Palozza, P. (2005). Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil. Cancer Chemother. Pharmacol. 55:12–20.
   PubMed Web of Science ®Google Scholar
• Calviello, G., Palozza, P., Franceschelli, P. and Bartoli, G. M. (1997). Low-dose eicosapentaenoic or docosahexaenoic acid administration modifies fatty acid composition and does not affect susceptibility to oxidative stress in rat erythrocytes and tissues. Lipids 32:1075–1083.
   PubMed Web of Science ®Google Scholar
• Calviello, G., Palozza, P., Piccioni, E., Maggiano, N., Frattucci, A., Franceschelli, P. and Bartoli, G. M. (1998). Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: Effects on proliferation and apoptosis. Int. J. Cancer 75:699–705.
   PubMed Web of Science ®Google Scholar
• Calviello, G., Resci, F., Serini, S., Piccioni, E., Toesca, A., Boninsegna, A., Monego, G., Ranelletti, F. O. and Palozza, P. (2007). Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. Carcinogenesis 28:1202–1209.
   PubMed Web of Science ®Google Scholar
• Calviello, G. and Serini, S. (2010). ω-3 PUFAs, why are we speaking of them? In: Dietary omega-3 Polyunsaturated Fatty Acids and Cancer (Series: Diet and Cancer), pp. ix–xxi. Calviello, G. and Serini, S., Eds., Springer, Dordrecht.
   Google Scholar
• Calviello, G., Serini, S. and Palozza, P. (2006). n-3 polyunsaturated fatty acids as signal transduction modulators and therapeutical agents in cancer. Curr Signal Transd T 1:255–271.
   Web of Science ®Google Scholar
• Chan, J. M., Weinberg, V., Magbanua, M. J., Sosa, E., Simko, J., Shinohara, K., Federman, S., Mattie, M., Hughes-Fulford, M., Haqq, C. and Carroll, P. R. (2011). Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer. Cancer Causes Control 22:141–150.
   PubMed Web of Science ®Google Scholar
• Chatterjee, M., Janarthan, M., Manivannan, R., Rana, A. and Chatterjee, M. (2010). Combinatorial effect of fish oil (Maxepa) and 1alpha,25-dihydroxyvitamin D(3) in the chemoprevention of DMBA-induced mammary carcinogenesis in rats. Chem. Biol. Interact. 188:102–110.
   PubMed Web of Science ®Google Scholar
• Colas, S., Mahéo, K., Denis, F., Goupille, C., Hoinard, C., Champeroux, P., Tranquart, F. and Bougnoux, P. (2006). Sensitization by dietary docosahexaenoic acid of rat mammary carcinoma to anthracycline: A role for tumor vascularization. Clin. Cancer Res. 12:5879–5886.
   PubMed Web of Science ®Google Scholar
• Connolly, J. M., Coleman, M. and Rose, D. P. (1997a). Effects of dietary fatty acids on DU145 human prostate cancer cell growth in athymic nude mice. Nutr. Cancer 29:114–119.
   PubMed Web of Science ®Google Scholar
• Connolly, J. M., Gilhooly, E. M. and Rose, D. P. (1999). Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude mice. Nutr. Cancer 35:44–49.
   PubMed Web of Science ®Google Scholar
• Connolly, J. M., Liu, X. H. and Rose, D. P. (1997b). Effects of dietary menhaden oil, soy, and a cyclooxygenase inhibitor on human breast cancer cell growth and metastasis in nude mice. Nutr. Cancer 29:48–54.
   PubMed Web of Science ®Google Scholar
• EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). (2012). EFSA Journal 10:2815.
   Google Scholar
• Fasano, E., Serini, S., Piccioni, E., Toesca, A., Monego, G., Cittadini, A. R., Ranelletti, F. O. and Calviello, G. (2012). DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochim. Biophys. Acta 1822:1762–1772.
   PubMed Web of Science ®Google Scholar
• Fernandes, G., Chandrasekar, B., Troyer, D. A., Venkatraman, J. T. and Good, R. A. (1995). Dietary lipids and calorie restriction affect mammary tumor incidence and gene expression in mouse mammary tumor virus/v-Ha-ras transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 92:6494–6498.
   PubMed Web of Science ®Google Scholar
• Gabor, H. and Abraham, S. (1986). Effect of dietary menhaden oil on tumor cell loss and the accumulation of mass of a transplantable mammary adenocarcinoma in BALB/c mice. J. Natl. Cancer Inst. 76:1223–1229.
   PubMed Web of Science ®Google Scholar
• Gabor, H., Blank, E. W. and Ceriani, R. L. (1990). Effect of dietary fat and monoclonal antibody therapy on the growth of human mammary adenocarcinoma MX-1 grafted in athymic mice. Cancer Lett. 52:173–178.
   PubMed Web of Science ®Google Scholar
• Ghosh-Choudhury, T., Mandal, C. C., Woodruff, K., St Clair, P., Fernandes, G., Choudhury, G. G. and Ghosh-Choudhury, N. (2009). Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast tumor growth. Breast Cancer Res. Treat. 118:213–228.
   PubMed Web of Science ®Google Scholar
• Gonzalez, M. J., Schemmel, R. A., Dugan, L. Jr, Gray, J. I. and Welsch, C. W. (1993). Dietary fish oil inhibits human breast carcinoma growth: A function of increased lipid peroxidation. Lipids 28:827–832.
   PubMed Web of Science ®Google Scholar
• Gonzalez, M. J., Schemmel, R. A., Gray, J. I., Dugan, L. Jr, Sheffield, L. G. and Welsch, C. W. (1991). Effect of dietary fat on growth of MCF-7 and MDA-MB231 human breast carcinomas in athymic nude mice: Relationship between carcinoma growth and lipid peroxidation product levels. Carcinogenesis 12:1231–1235.
   PubMed Web of Science ®Google Scholar
• Hamid, R., Singh, J., Reddy, B. S. and Cohen, L. A. (1999). Inhibition by dietary menhaden oil of cyclooxygenase-1 and -2 in N-nitrosomethylurea-induced rat mammary tumors. Int. J. Oncol. 14:523–528.
   PubMed Web of Science ®Google Scholar
• Hardman, W. E., Avula, C. P., Fernandes, G. and Cameron, I. L. (2001). Three percent dietary fish oil concentrate increased efficacy of doxorubicin against MDA-MB 231 breast cancer xenografts. Clin. Cancer Res. 7:2041–2049.
   PubMed Web of Science ®Google Scholar
• Hardman, W. E., Sun, L., Short, N. and Cameron, I. L. (2005). Dietary omega-3 fatty acids and ionizing irradiation on human breast cancer xenograft growth and angiogenesis. Cancer Cell Int. 5:12.
   PubMed Web of Science ®Google Scholar
• Harris, W. S., Sands, S. A., Windsor, S. L., Ali, H. A., Stevens, T. L., Magalski, A., Porter, C. B. and Borkon, A. M. (2004). Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: Correlation with erythrocytes and response to supplementation. Circulation 110:1645–1649.
   PubMed Web of Science ®Google Scholar
• Hu, Y., Sun, H., Owens, R. T., Gu, Z., Wu, J., Chen, Y. Q., O'Flaherty, J. T. and Edwards, I. J. (2010). Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer. Neoplasia 12:826–836.
   PubMed Web of Science ®Google Scholar
• Hubbard, N. E., Lim, D. and Erickson, K. L. (1998). Alteration of murine mammary tumorigenesis by dietary enrichment with n-3 fatty acids in fish oil. Cancer Lett. 124:1–7.
   PubMed Web of Science ®Google Scholar
• Hudson, E. A., Beck, S. A. and Tisdale, M. J. (1993). Kinetics of the inhibition of tumour growth in mice by eicosapentaenoic acid-reversal by linoleic acid. Biochem. Pharmacol. 45:2189–2194.
   PubMed Web of Science ®Google Scholar
• Jourdan, M. L., Mahéo, K., Barascu, A., Goupille, C., De Latour, M. P., Bougnoux, P. and Rio, P. G. (2007). Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids. Oncol. Rep. 17:713–719.
   PubMed Web of Science ®Google Scholar
• Jurkowski, J. J. and Cave, W. T. Jr. (1985). Dietary effects of menhaden oil on the growth and membrane lipid composition of rat mammary tumors. J. Natl. Cancer Inst. 74:1145–1150.
   PubMed Web of Science ®Google Scholar
• Kang, J. X. (2007). Fat-1 transgenic mice: A new model for omega-3 research. Prostaglandins Leukot. Essent. Fatty Acids 77:263–267.
   PubMed Web of Science ®Google Scholar
• Karmali, R. A., Donner, A., Gobel, S. and Shimamura, T. (1989). Effect of n-3 and n-6 fatty acids on 7,12 dimethylbenz (a) anthracene-induced mammary tumorigenesis. Anticancer Res. 9:1161–1167.
   PubMed Web of Science ®Google Scholar
• Karmali, R. A., Marsh, J. and Fuchs, C. (1984). Effect of omega-3 fatty acids on growth of a rat mammary tumor. J. Natl. Cancer Inst. 73:457–461.
   PubMed Web of Science ®Google Scholar
• Karmali, R. A., Reichel, P., Cohen, L. A., Terano, T., Hirai, A., Tamura, Y. and Yoshida, S. (1987). The effects of dietary omega-3 fatty acids on the DU-145 transplantable human prostatic tumor. Anticancer Res. 7:1173–1179.
   PubMed Web of Science ®Google Scholar
• Katan, M. B., Deslypere, J. P., van Birgelen, A. P., Penders, M. and Zegwaard, M. (1997). Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: An 18-month controlled study. J. Lipid Res. 38:2012–2022.
   PubMed Web of Science ®Google Scholar
• Kelavkar, U. P., Hutzley, J., Dhir, R., Kim, P., Allen, K. G. and McHugh, K. (2006). Prostate tumor growth and recurrence can be modulated by the omega-6:omega-3 ratio in diet: Athymic mouse xenograft model simulating radical prostatectomy. Neoplasia 8:112–124.
   PubMed Web of Science ®Google Scholar
• Kelavkar, U. P., Hutzley, J., McHugh, K., Allen, K. G. and Parwani, A. (2009). Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes. Neoplasia 11:692–699.
   PubMed Web of Science ®Google Scholar
• Kim, W., McMurray, D. N. and Chapkin, R. S. (2010). n-3 polyunsaturated fatty acids-physiological relevance of dose. Prostaglandins. Leukot. Essent. Fatty Acids 82:155–158.
   PubMed Web of Science ®Google Scholar
• Kobayashi, N., Barnard, R. J., Henning, S. M., Elashoff, D., Reddy, S. T., Cohen, P., Leung, P., Hong-Gonzalez, J., Freedland, S. J., Said, J., Gui, D., Seeram, N. P., Popoviciu, L. M., Bagga, D., Heber, D., Glaspy, J. A. and Aronson, W. J. (2006). Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. Clin. Cancer Res. 12:4662–4670.
   PubMed Web of Science ®Google Scholar
• Lin, P. Y., Romsos, D. R. and Leveille, G. A. (1977). Food intake, body weight gain, and body composition of the young obese (ob/ob) mouse. J. Nutr. 107:1715–1723.
   PubMed Web of Science ®Google Scholar
• Mandal, C. C., Ghosh-Choudhury, T., Yoneda, T., Choudhury, G. G. and Ghosh-Choudhury, N. (2010). Fish oil prevents breast cancer cell metastasis to bone. Biochem. Biophys. Res. Commun. 402:602–607.
   PubMed Web of Science ®Google Scholar
• Manna, S., Chakraborty, T., Damodaran, S., Samanta, K., Rana, B. and Chatterjee, M. (2007). Protective role of fish oil (Maxepa) on early events of rat mammary carcinogenesis by modulation of DNA-protein crosslinks, cell proliferation and p53 expression. Cancer Cell Int. 7:6.
   PubMed Web of Science ®Google Scholar
• Manna, S., Chakraborty, T., Ghosh, B., Chatterjee, M., Panda, A., Srivastava, S., Rana, A. and Chatterjee, M. (2008). Dietary fish oil associated with increased apoptosis and modulated expression of Bax and Bcl-2 during 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats. Prostaglandins Leukot. Essent. Fatty Acids 79:5–14.
   PubMed Web of Science ®Google Scholar
• Manni, A., Richie, J. P. Jr, Xu, H., Washington, S., Aliaga, C., Cooper, T. K., Bruggeman, R., Das, A., Prokopczyk, B., Calcagnotto, A., Trushin, N., Dickinson, R., Liao, J., Verderame, M. F. and El-Bayoumy, K. (2011). Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Int. J. Oncol. 39:115311–115364.
   Web of Science ®Google Scholar
• Manni, A., Xu, H., Washington, S., Aliaga, C., Cooper, T., Richie, J. P. Jr, Bruggeman, R., Prokopczyk, B., Calcagnotto, A., Trushin, N., Mauger, D., Verderame, M. F. and El-Bayoumy, K. (2010). The impact of fish oil on the chemopreventive efficacy of tamoxifen against development of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Cancer Prev. Res. (Phila) 3:322–330.
   PubMed Web of Science ®Google Scholar
• McEntee, M. F., Ziegler, C., Reel, D., Tomer, K., Shoieb, A., Ray, M., Li, X., Neilsen, N., Lih, F. B., O'Rourke, D. and Whelan, J. (2008). Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. Am. J. Pathol. 173:229–241.
   PubMed Web of Science ®Google Scholar
• Minami, M. and Noguchi, M. (1996). Effects of low-dose eicosapentaenoic acid, docosahexaenoic acid and dietary fat on the incidence, growth and cell kinetics of mammary carcinomas in rats. Oncology 53:398–405.
   PubMed Web of Science ®Google Scholar
• Mukutmoni-Norris, M., Hubbard, N. E. and Erickson, K. L. (2000). Modulation of murine mammary tumor vasculature by dietary n-3 fatty acids in fish oil. Cancer Lett. 150:101–109.
   PubMed Web of Science ®Google Scholar
• Mund, R. C., Pizato, N., Bonatto, S., Nunes, E. A., Vicenzi, T., Tanhoffer, R., de Oliveira, H. H., Curi, R., Calder, P. C. and Fernandes, L. C. (2007). Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation. Prostaglandins Leukot. Essent. Fatty Acids 76:113–120. 17.
   PubMed Web of Science ®Google Scholar
• NCT00253643. OHSU Knight Cancer Institute. Fish Oil and Green Tea Extract in Preventing Prostate Cancer in Patients Who Are at Risk for Developing Prostate Cancer. ClinicalTrial.gov.
   Google Scholar
• NCT00996749. Comprehensive Cancer Center of Wake Forest University. Omega-3 Fatty Acids in Treating Patients With Advanced Prostate Cancer. ClinicalTrial.gov.
   Google Scholar
• Noguchi, M., Minami, M., Yagasaki, R., Kinoshita, K., Earashi, M., Kitagawa, H., Taniya, T. and Miyazaki, I. (1997). Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. Br. J. Cancer 75:348–353.
   PubMed Web of Science ®Google Scholar
• Olivo, S. E. and Hilakivi-Clarke, L. (2005). Opposing effects of prepubertal low- and high-fat n-3 polyunsaturated fatty acid diets on rat mammary tumorigenesis. Carcinogenesis 26:1563–1572.
   PubMed Web of Science ®Google Scholar
• Pizato, N., Bonatto, S., Yamazaki, R. K., Aikawa, J., Nogata, C., Mund, R. C., Nunes, E. A., Piconcelli, M., Naliwaiko, K., Curi, R., Calder, P. C. and Fernandes, L. C. (2005). Ratio of n6 to n-3 fatty acids in the diet affects tumor growth and cachexia in Walker 256 tumor-bearing rats. Nutr. Cancer 53:194–201.
   PubMed Web of Science ®Google Scholar
• Pritchard, G. A., Jones, D. L. and Mansel, R. E. (1989). Lipids in breast carcinogenesis. Br. J. Surg. 76:1069–1073.
   PubMed Web of Science ®Google Scholar
• Robinson, L. E., Clandinin, M. T. and Field, C. J. (2001). R3230AC rat mammary tumor and dietary long-chain (n-3) fatty acids change immune cell composition and function during mitogen activation. J. Nutr. 131:2021–2027.
   PubMed Web of Science ®Google Scholar
• Rose, D. P. and Cohen, L. A. (1988). Effects of dietary menhaden oil and retinyl acetate on the growth of DU 145 human prostatic adenocarcinoma cells transplanted into athymic nude mice. Carcinogenesis 9:603–605.
   PubMed Web of Science ®Google Scholar
• Rose, D. P. and Connolly, J. M. (1993). Effects of dietary omega-3 fatty acids on human breast cancer growth and metastases in nude mice. J. Natl. Cancer Inst. 85:1743–1747.
   PubMed Web of Science ®Google Scholar
• Rose, D. P., Connolly, J. M. and Coleman, M. (1996). Effect of omega-3 fatty acids on the progression of metastases after the surgical excision of human breast cancer cell solid tumors growing in nude mice. Clin. Cancer Res. 2:1751–1756.
   PubMed Web of Science ®Google Scholar
• Rose, D. P., Connolly, J. M., Rayburn, J. and Coleman, M. (1995). Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice. J. Natl. Cancer Inst. 87:587–592.
   PubMed Web of Science ®Google Scholar
• Senzaki, H., Iwamoto, S., Ogura, E., Kiyozuka, Y., Arita, S., Kurebayashi, J., Takada, H., Hioki, K. and Tsubura, A. (1998). Dietary effects of fatty acids on growth and metastasis of KPL-1 human breast cancer cells in vivo and in vitro. Anticancer Res. 18:1621–1627.
   PubMed Web of Science ®Google Scholar
• Serini, S., Fasano, E., Piccioni, E., Cittadini, A. R. and Calviello, G. (2011). Dietary n-3 polyunsaturated fatty acids and the paradox of their health benefits and potential harmful effects. Chem. Res. Toxicol. 24:2093–2105.
   PubMed Web of Science ®Google Scholar
• Serini, S., Fasano, E., Piccioni, E., Monego, G., Cittadini, A. R., Celleno, L., Ranelletti, F. O. and Calviello, G. (2012). DHA induces apoptosis and differentiation in human melanoma cells in vitro: Involvement of HuR-mediated COX-2 mRNA stabilization and β-catenin nuclear translocation. Carcinogenesis 33:164–173.
   PubMed Web of Science ®Google Scholar
• Serini, S., Innocenti, I., Piccioni, E. and Calviello, G. The effects of omega-3 polyunsaturated fatty acids against cancer. In: “Vitamins in the prevention of human diseases pp 679–696 Hermann/Obeid Ed, De Gruyter, Berlin 2010.
   Google Scholar
• Serini, S., Piccioni, E., Merendino, N. and Calviello, G. (2009). Dietary polyunsaturated fatty acids as inducers of apoptosis: Implications for cancer. Apoptosis 14:135–152.
   PubMed Web of Science ®Google Scholar
• Serini, S., Trombino, S., Oliva, F., Piccioni, E., Monego, G., Resci, F., Boninsegna, A., Picci, N., Ranelletti, F. O. and Calviello, G. (2008). Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression. Apoptosis 13:1172–1183.
   PubMed Web of Science ®Google Scholar
• Shao, Y., Pardini, L. and Pardini, R. S. (1995). Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1. Lipids 30:1035–1045.
   PubMed Web of Science ®Google Scholar
• Shao, Y., Pardini, L. and Pardini, R. S. (1997). Intervention of transplantable human mammary carcinoma MX-1 chemotherapy with dietary menhaden oil in athymic mice: Increased therapeutic effects and decreased toxicity of cyclophosphamide. Nutr. Cancer 28:63–73.
   PubMed Web of Science ®Google Scholar
• Simopoulos, A. P., Leaf, A. and Salem, N. Jr. (1999). Essentiality of and recommended dietary intakes for omega-6 and omega-3 fatty acids. Ann. Nutr. Metab. 43:127–130.
   PubMedGoogle Scholar
• Suzuki, H., Freije, D., Nusskern, D. R., Okami, K., Cairns, P., Sidransky, D., Isaacs, W. B. and Bova, G. S. (1998). Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res. 58:204–209.
   PubMed Web of Science ®Google Scholar
• Togni, V., Ota, C. C., Folador, A., Júnior, O. T., Aikawa, J., Yamazaki, R. K., Freitas, F. A., Longo, R., Martins, E. F., Calder, P. C., Curi, R. and Fernandes, L. C. (2003). Cancer cachexia and tumor growth reduction in Walker 256 tumor-bearing rats supplemented with N-3 polyunsaturated fatty acids for one generation. Nutr. Cancer 46:52–58.
   PubMed Web of Science ®Google Scholar
• Tynan, M. B., Nicholls, D. P., Maguire, S. M., Steele, I. C., McMaster, C., Moore, R., Trimble, E. R. and Pearce, J. (1995). Erythrocyte membrane fatty acid composition as a marker of dietary compliance in hyperlipidaemic subjects. Atherosclerosis 117:245–252.
   PubMed Web of Science ®Google Scholar
• Vissapragada, S., Ghosh, A., Ringer, L., Salinas, P., Brophy, A., Peaceman, D., Kallakury, B., Banerjee, P. P., Fricke, S. T., Helfrich, W., Lee, Y. C., Pestell, R., Scherer, P., Tanowitz, H. B., Avantaggiati, M. L., Hilakivi-Clarke, L., Lisanti, M. P., Rodriguez, O. C. and Albanese, C. (2010). Dietary n-3 polyunsaturated fatty acids fail to reduce prostate tumorigenesis in the PB-ErbB-2 x Pten(+/−) preclinical mouse model. Cell Cycle 9:1824–1829.
   PubMed Web of Science ®Google Scholar
• Vlietstra, R. J., van Alewijk, D. C., Hermans, K. G., van Steenbrugge, G. J. and Trapman, J. (1998). Frequent inactivation of PTEN in prostate cancer cell lines and xenografts. Cancer Res. 58:2720–2723.
   PubMed Web of Science ®Google Scholar
• Wang, S., Wu, J., Suburu, J., Gu, Z., Cai, J., Axanova, L. S., Cramer, S. D., Thomas, M. J., Perry, D. L., Edwards, I. J., Mucci, L. A., Sinnott, J. A., Loda, M. F., Sui, G., Berquin, I. M. and Chen, Y. Q. (2012). Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer. Carcinogenesis 33:404–412.
   PubMed Web of Science ®Google Scholar
• Welsch, C., Welsch, M., Huelskamp, L., Gonzalez, M. and Vanderploeg, L. (1995). Influence of dietary-fat on growth of mda-mb231 human breast carcinomas maintained in female athymic nude-mice. Int. J. Oncol. 6:55–64.
   PubMed Web of Science ®Google Scholar
• West, N. J., Clark, S. K., Phillips, R. K. S., Hutchinson, J. M., Leicester, R. J., Belluzzi, A. and Hull, M. A. (2010). Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis. Gut 59:918–925.
   PubMed Web of Science ®Google Scholar
• Wu, M., Harvey, K. A., Ruzmetov, N., Welch, Z. R., Sech, L., Jackson, K., Stillwell, W., Zaloga, G. P. and Siddiqui, R. A. (2005). Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway. Int. J. Cancer 117:340–348.
   PubMed Web of Science ®Google Scholar
• Yee, L. D., Lester, J. L., Cole, R. M., Richardson, J. R., Hsu, J. C., Li, Y., Lehman, A., Belury, M. A. and Clinton, S. K. (2010). Omega-3 fatty acid supplements in women at high risk of breast cancer have dose-dependent effects on breast adipose tissue fatty acid composition. Am. J. Clin. Nutr. 91:1185–1194.
   PubMed Web of Science ®Google Scholar
• Yee, L. D., Young, D. C., Rosol, T. J., Vanbuskirk, A. M. and Clinton, S. K. (2005). Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazone. J. Nutr. 135:983–988.
   PubMed Web of Science ®Google Scholar
• Yuri, T., Danbara, N., Tsujita-Kyutoku, M., Fukunaga, K., Takada, H., Inoue, Y., Hada, T. and Tsubura, A. (2003). Dietary docosahexaenoic acid suppresses N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats more effectively than eicosapentaenoic acid. Nutr. Cancer 45:211–217.
   PubMed Web of Science ®Google Scholar
• Zhu, Z., Jiang, W., McGinley, J. N., Prokopczyk, B., Richie, J. P. Jr, El Bayoumy, K., Manni, A. and Thompson, H. J. (2011). Mammary gland density predicts the cancer inhibitory activity of the N-3 to N-6 ratio of dietary fat. Cancer Prev. Res. (Phila) 4:1675–1685.
   PubMed Web of Science ®Google Scholar