Sorghum (Sorghum bicolor L.): Nutrients, bioactive compounds, and potential impact on human health

References

• Abdel-Aal, E.-S. M., Choo, T.-M., Dhillon, S. and Rabalski, I. (2012). Free and bound phenolic acids and total phenolics in black, blue, and yellow barley and their contribution to free radical scavenging capacity. Cereal Chem. J. 89:198–204.
   Web of Science ®Google Scholar
• Abdel-Rahman, I. E. and Osman, M. A. W. (2011). Effect of sorghum type (Sorghum bicolor) and traditional fermentation on tannins and phytic acid contents and trypsin inhibitor activity. Food Agr. Environ. 9:163–166.
   Web of Science ®Google Scholar
• Afify, A. E.-M. M. R., El-Beltagi, H. S., Abd El-Salam, S. M. and Omran, A. A. (2011). Bioavailability of iron, zinc, phytate and phytase activity during soaking and germination of white sorghum varieties. PLoS ONE 6:255–212.
   Web of Science ®Google Scholar
• Afify, A. E.-M. M. R., El-Beltagi, H. S., Abd El-Salam, S. M. and Omran, A. A. (2012a). Oil and fatty acid contents of white sorghum varieties under soaking, cooking, germination and fermentation processing for improving cereal quality. Not. Bot. Horti. Agrobo. 40:86–92.
   Web of Science ®Google Scholar
• Afify, A. E.-M. M. R., El-Beltagi, H. S., Abd El-Salam, S. M. and Omran, A. A. (2012b). Protein solubility, digestibility and fractionation after germination of sorghum varieties. PLoS ONE 7:e31154.
   PubMed Web of Science ®Google Scholar
• Afify, A. E.-M. M. R., El-Beltagi, H. S., El-Salam, S. M. A. and Omran, A. A. (2012c). Biochemical changes in phenols, flavonoids, tannins, vitamin E, β–carotene and antioxidant activity during soaking of three white sorghum varieties. Asian Pac. J. Trop. Biomed. 2:203–209.
   PubMedGoogle Scholar
• Al-Mamary, M., Molham, A.-H., Abdulwali, A.-A. and Al-Obeidi, A. (2001). In vivo effects of dietary sorghum tannins on rabbit digestive enzymes and mineral absorption. Nutrit. Res. 21:1393–1401.
   Web of Science ®Google Scholar
• Ali, N. M. M., El Tinay, A. H., Elkhalifa, A. E. O., Salih, O. A. and Yousif, N. E. (2009). Effect of alkaline pretreatment and cooking on protein fractions of a high-tannin sorghum cultivar. Food Chem. 114:646–648.
   Web of Science ®Google Scholar
• Amiot, M. J., Knol, D., Cardinault, N., Nowicki, M., Bott, R., Antona, C., Borel, P., Bernard, J.-P., Duchateau, G. and Lairon, D. (2011). Phytosterol ester processing in the small intestine: impact on cholesterol availability for absorption and chylomicron cholesterol incorporation in healthy humans. J. Lipid Res. 52:1256–1264.
   PubMed Web of Science ®Google Scholar
• Amiot, M. J., Knol, D., Cardinault, N., Nowicki, M., Bott, R., Antona, C., Borel, P., Bernard, J.-P., Duchateau, G. and Lairon, D. (2013). Comparable reduction in cholesterol absorption after two different ways of phytosterol administration in humans. Eur. J. Nutrit. 55:1–8.
   Google Scholar
• Ashok Kumar, A., Reddy, B. V. S., Ramaiah, B., Sahrawat, K. L. and Pfeiffer, W. H. (2013). Gene effects and heterosis for grain iron and zinc concentration in sorghum [Sorghum bicolor (L.) Moench]. Field Crop. Res. 146:86–95.
   Web of Science ®Google Scholar
• Awika, J. M. (2003). Antioxidant Properties of Sorghum. Texas A&M University, College Station, Texas.
   Google Scholar
• Awika, J. M. (2008). Behavior of 3-deoxyanthocyanidins in the presence of phenolic copigments. Food Res. Int. 41:532–538.
   Web of Science ®Google Scholar
• Awika, J. M., Dykes, L., Gu, L., Rooney, L. W. and Prior, R. L. (2003). Processing of sorghum (Sorghum bicolor) and sorghum products alters procyanidin oligomer and polymer distribution and content. J. Agr. Food Chem. 51:5516–5521.
   PubMed Web of Science ®Google Scholar
• Awika, J. M., McDonough, C. M. and Rooney, L. W. (2005). Decorticating sorghum to concentrate healthy phytochemicals. J. Agr. Food Chem. 53:6230–6234.
   PubMed Web of Science ®Google Scholar
• Awika, J. M. and Rooney, L. W. (2004). Sorghum phytochemicals and their potential impact on human health. PhytoChem. 65:1199–1221.
   PubMed Web of Science ®Google Scholar
• Awika, J. M., Rooney, L. W. and Waniska, R. D. (2004). Properties of 3-deoxyanthocyanins from sorghum. J. Agr. Food Chem. 52:4388–4394.
   PubMed Web of Science ®Google Scholar
• Awika, J. M., Yang, L., Browning, J. D. and Faraj, A. (2009). Comparative antioxidant, antiproliferative and phase II enzyme inducing potential of sorghum (Sorghum bicolor) varieties. LWT - Food Sci. Technol. 42:1041–1046.
   Web of Science ®Google Scholar
• Barros, F., Awika, J. and Rooney, L. W. (2013). Effect of molecular weight profile of sorghum proanthocyanidins on resistant starch formation. J. Sci. Food Agr. n/a-n/a.
   PubMed Web of Science ®Google Scholar
• Barros, F., Awika, J. M. and Rooney, L. W. (2012). Interaction of tannins and other sorghum phenolic compounds with starch and effects on in vitro starch digestibility. J. Agric. Food Chem. 60:11609–11617.
   PubMed Web of Science ®Google Scholar
• Beecher, G. R. (2004). Proanthocyanidins: Biological activities associated with human health. Pharm. Biol. 42:2–20.
   Web of Science ®Google Scholar
• Belton, P. S., Delgadillo, I., Halford, N. G. and Shewry, P. R. (2006). Kafirin structure and functionality. J. Cereal Sci. 44:272–286.
   Web of Science ®Google Scholar
• Bralley, E., Greenspan, P., Hargrove, J. L. and Hartle, D. K. (2008). Inhibition of hyaluronidase activity by select sorghum brans. J. Med. Med. Food 11:307–312.
   PubMed Web of Science ®Google Scholar
• Bröhan, M., Jerkovic, V. and Collin, S. (2011). Potentiality of red sorghum for producing stilbenoid-enriched beers with high antioxidant activity. J. Agric. Food Chem. 59:4088–4094.
   PubMed Web of Science ®Google Scholar
• Burdette, A., Garner, P. L., Mayer, E. P., Hargrove, J. L., Hartle, D. K. and Greenspan, P. (2010). Anti-inflammatory activity of select sorghum (Sorghum bicolor) brans. J. Med. Food 13:1–9.
   PubMed Web of Science ®Google Scholar
• Cardona, F., Andrés-Lacueva, C., Tulipani, S., Tinahones, F. J. and Queipo-Ortuño, M. I. (2013). Benefits of polyphenols on gut microbiota and implications in human health. J. Nutr. Biochem. 24:1415–1422.
   PubMed Web of Science ®Google Scholar
• Cardoso, L. d. M., Montini, T. A., Pinheiro, S. S., Pinheiro Sant'Ana, H. M., Martino, H. S. D. and Moreira, A. V. B. (2014). Effects of processing with dry heat and wet heat on the antioxidant profile of sorghum (Sorghum bicolor L.). Food Chem. 152:201–217.
   Web of Science ®Google Scholar
• Carr, T. P., Weller, C. L., Schlegel, V. L., Cuppett, S. L., Guderian, D. M. and Johnson, K. R. (2005). Grain sorghum lipid extract reduces cholesterol absorption and plasma non-HDL cholesterol concentration in hamsters. J. Nutrit. 135:2236–2240.
   PubMed Web of Science ®Google Scholar
• Chiremba, C., Taylor, J. R. N., Rooney, L. W. and Beta, T. (2012). Phenolic acid content of sorghum and maize cultivars varying in hardness. Food Chem. 134:81–88.
   Web of Science ®Google Scholar
• Cho, S. H., Choi, Y. and Ha, T. Y. (2000). In vitro and in vivo effects of prosomillet, buckwheat and sorghum on cholesterol metabolism. FASEB J. 14:249–249.
   Web of Science ®Google Scholar
• Chong, J., Poutaraud, A. and Hugueney, P. (2009). Metabolism and roles of stilbenes in plants. Plant Sci. 177:143–155.
   Web of Science ®Google Scholar
• Chung, I.-M., Kim, E.-H., Yeo, M.-A., Kim, S.-J., Seo, M. C. and Moon, H.-I. (2011a). Antidiabetic effects of three Korean sorghum phenolic extracts in normal and streptozotocin-induced diabetic rats. Food Res. Int. 44:127–132.
   Web of Science ®Google Scholar
• Chung, I.-M., Yeo, M.-A., Kim, S.-J., Kim, M.-J., Park, D.-S. and Moon, H.-I. (2011b). Antilipidemic activity of organic solvent extract from Sorghum bicolor on rats with diet-induced obesity. Human Exp. Toxicol. 30:1865–1868.
   PubMed Web of Science ®Google Scholar
• Chung, I.-M., Yong, S.-J., Lee, J. and Kim, S.-H. (2013). Effect of genotype and cultivation location on β-sitosterol and α-, β-, γ-, and δ-tocopherols in sorghum. Food Res. Int. 51:971–976.
   Web of Science ®Google Scholar
• Ciacci, C., Maiuri, L., Caporaso, N., Bucci, C., Del Giudice, L., Rita Massardo, D., Pontieri, P., Di Fonzo, N., Bean, S. R., Ioerger, B. and Londei, M. (2007). Celiac disease: In vitro and in vivo safety and palatability of wheat-free sorghum food products. Clin. Nutr. 26:799–805.
   PubMed Web of Science ®Google Scholar
• Clemente, Jose.C., Ursell, Luke.K., Parfrey, Laura.W. and Knight, R. (2012). The impact of the gut microbiota on human health: an integrative view. Cell 148:1258–1270.
   PubMed Web of Science ®Google Scholar
• Correia, I., Nunes, A., Barros, A. S. and Delgadillo, I. (2008). Protein profile and malt activity during sorghum germination. J. Sci. Food Agr. 88:2598–2605.
   Web of Science ®Google Scholar
• Crozier, A., Del Rio, D. and Clifford, M. N. (2010). Bioavailability of dietary flavonoids and phenolic compounds. Mol. Aspect Med. 31:446–467.
   PubMed Web of Science ®Google Scholar
• Crozier, A., Jaganath, I. B. and Clifford, M. N. (2009). Dietary phenolics: chemistry, bioavailability and effects on health. Nat. Prod. Rep. 26:1001–1043.
   PubMed Web of Science ®Google Scholar
• D'Archivio, M., Filesi, C., Varì, R., Scazzocchio, B. and Masella, R. (2010). Bioavailability of the polyphenols: status and controversies. Int. J. Mol. Sci. 11:1321–1342.
   PubMed Web of Science ®Google Scholar
• da Silva, L. S., Jung, R., Zhao, Z.-y., Glassman, K., Taylor, J. and Taylor, J. R. N. (2011a). Effect of suppressing the synthesis of different kafirin sub-classes on grain endosperm texture, protein body structure and protein nutritional quality in improved sorghum lines. J. Cereal Sci. 54:160–167.
   Web of Science ®Google Scholar
• da Silva, L. S., Taylor, J. and Taylor, J. R. (2011b). Transgenic sorghum with altered kafirin synthesis: kafirin solubility, polymerization, and protein digestion. J. Agric. Food Chem. 59:9265–9270.
   PubMed Web of Science ®Google Scholar
• De Mesa-Stonestreet, N. J., Alavi, S. and Bean, S. R. (2010). Sorghum proteins: the concentration, isolation, modification, and food applications of kafirins. J. Food Sci. 75:90–104.
   PubMed Web of Science ®Google Scholar
• Delgado-Zamarreño, M., Bustamante-Rangel, M., Martínez-Pelarda, D. and Carabías-Martínez, R. (2009). Analysis of β-sitosterol in seeds and nuts using pressurized liquid extraction and liquid chromatography. Anal. Sci. 25:765–768.
   PubMed Web of Science ®Google Scholar
• Dicko, M. H., Gruppen, H., Barro, C., Traore, A. S., van Berkel, W. J. and Voragen, A. G. (2005). Impact of phenolic compounds and related enzymes in sorghum varieties for resistance and susceptibility to biotic and abiotic stresses. J. Chem. Ecol. 31:2671–2688.
   PubMed Web of Science ®Google Scholar
• Dillon, S. L., Shapter, F. M., Henry, R. J., Cordeiro, G., Izquierdo, L. and Lee, L. S. (2007). Domestication to crop improvement: genetic resources for sorghum and saccharum (Andropogoneae). Ann. Bot. 100:975–989.
   PubMed Web of Science ®Google Scholar
• Dixon, R. A., Xie, D.-Y. and Sharma, S. B. (2005). Proanthocyanidins—a final frontier in flavonoid research? New Phytol. 165:9–28.
   PubMed Web of Science ®Google Scholar
• Dolara, P., Luceri, C., Filippo, C. D., Femia, A. P., Giovannelli, L., Caderni, G., Cecchini, C., Silvi, S., Orpianesi, C. and Cresci, A. (2005). Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. Mutation Res./λατνϵμαδνυΦ σισϵνϵγατυμ φο σμσιναηχϵμ ραλυχϵλομ δνα 195:642–732.
   Google Scholar
• Donovan, J. L., Manach, C., Faulks, R. M. and Kroon, P. A. (2007). Absorption and metabolism of dietary plant secondary metabolites. In: Plant Secondary Metabolites, pp. 303–351. Blackwell Publishing Ltd.
   Google Scholar
• Dowsett, M., Cuzick, J., Ingle, J., Coates, A., Forbes, J., Bliss, J., Buyse, M., Baum, M., Buzdar, A. and Colleoni, M. (2010). Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. J. Clin. Oncol. 28:509–518.
   PubMed Web of Science ®Google Scholar
• Duarte, S., Gregoire, S., Singh, A. P., Vorsa, N., Schaich, K., Bowen, W. H. and Koo, H. (2006). Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms. FEMS Microbiol. Lett. 257:50–56.
   PubMed Web of Science ®Google Scholar
• Duodu, K. G., Nunes, A., Delgadillo, I., Parker, M. L., Mills, E. N. C., Belton, P. S. and Taylor, J. R. N. (2002). Effect of grain structure and cooking on sorghum and maize in vitro protein digestibility. J. Cereal Sci. 35:161–174.
   Web of Science ®Google Scholar
• Duodu, K. G., Taylor, J. R. N., Belton, P. S. and Hamaker, B. R. (2003). Factors affecting sorghum protein digestibility. J. Cereal Sci. 38:117–131.
   Web of Science ®Google Scholar
• Dykes, L., Peterson, G. C., Rooney, W. L. and Rooney, L. W. (2011). Flavonoid composition of lemon-yellow sorghum genotypes. Food Chem. 128:173–179.
   PubMed Web of Science ®Google Scholar
• Dykes, L. and Rooney, L. W. (2006). Sorghum and millet phenols and antioxidants. J. Cereal Sci. 44:236–251.
   Web of Science ®Google Scholar
• Dykes, L., Rooney, L. W., Waniska, R. D. and Rooney, W. L. (2005). Phenolic compounds and antioxidant activity of sorghum grains of varying genotypes. J. Agric. Food Chem. 53:6813–6818.
   PubMed Web of Science ®Google Scholar
• Dykes, L., Rooney, W. L. and Rooney, L. W. (2013). Evaluation of phenolics and antioxidant activity of black sorghum hybrids. J. Cereal Sci. 58:278–283.
   Web of Science ®Google Scholar
• Dykes, L., Seitz, L. M., Rooney, W. L. and Rooney, L. W. (2009). Flavonoid composition of red sorghum genotypes. Food Chem. 116:313–317.
   Web of Science ®Google Scholar
• Earp, C. F., McDonough, C. M. and Rooney, L. W. (2004). Microscopy of pericarp development in the caryopsis of Sorghum bicolor (L.) Moench. J. Cereal Sci. 39:21–27.
   Web of Science ®Google Scholar
• Elkhalifa, A. E. O., Schiffler, B. and Bernhardt, R. (2005). Effect of fermentation on the functional properties of sorghum flour. Food Chem. 92:1–5.
   Web of Science ®Google Scholar
• ELKhier, M. K. S. and Abd-ALRaheem, A. A. (2011). Effect of fermentation period on the chemical composition, in vitro protein digestibility and tannin content in two Sorghum cultivars (Dabar and Tabat) in Sudan. J. Appl. Biosci. 39:2602–2606.
   Google Scholar
• Ezeogu, L. I., Duodu, K. G., Emmambux, M. N. and Taylor, J. R. N. (2008). Influence of cooking conditions on the protein matrix of sorghum and maize endosperm flours. Cereal Chem. J. 85:397–402.
   Web of Science ®Google Scholar
• Ezeogu, L. I., Duodu, K. G. and Taylor, J. R. N. (2005). Effects of endosperm texture and cooking conditions on the in vitro starch digestibility of sorghum and maize flours. J. Cereal Sci. 42:33–44.
   Web of Science ®Google Scholar
• Faria, A., Fernandes, I., Mateus, N. and Calhau, C. (2013). Bioavailability of Anthocyanins. In: Natural Products, pp. 2465–2487. Ramawat, K. G. and Mérillon, J.-M., Eds., Springer, Berlin Heidelberg.
   Google Scholar
• Farrar, J. L., Hartle, D. K., Hargrove, J. L. and Greenspan, P. (2008). A novel nutraceutical property of select sorghum (Sorghum bicolor) brans: inhibition of protein glycation. Phytotherapy Res. 22:1052–1056.
   PubMed Web of Science ®Google Scholar
• Fernandes, I., Faria, A., Calhau, C., de Freitas, V. and Mateus, N. (2014). Bioavailability of anthocyanins and derivatives. J. Funct. Foods. 7:54–66.
   Web of Science ®Google Scholar
• Ferreira, S. M. R., Luparelli, P. C., Schieferdecker, M. E. M. and Vilela, R. M. (2009). Cookies sem glúten a partir da farinha de sorgo. Archivos Latinoamericanos Nutr. 59:433–440.
   PubMedGoogle Scholar
• Floegel, A., Kim, D.-O., Chung, S.-J., Song, W. O., Fernandez, M. L., Bruno, R. S., Koo, S. I. and Chun, O. K. (2010). Development and validation of an algorithm to establish a total antioxidant capacity database of the US diet. Int. J. Food Sci.s Nutr. 61:600–623.
   PubMed Web of Science ®Google Scholar
• Food and Agricultural Organization. (2010). FAOSTAT. In). Rome, Italy.
   Google Scholar
• Food Security Department. (1999). Sorghum: Post-harvest Operations. United Kingdom: Natural Resources Institute, United Kingdom.
   Google Scholar
• Frazier, R. A., Deaville, E. R., Green, R. J., Stringano, E., Willoughby, I., Plant, J. and Mueller-Harvey, I. (2010). Interactions of tea tannins and condensed tannins with proteins. J. Pharm. Biomed. Anal. 51:490–495.
   PubMed Web of Science ®Google Scholar
• Fuentes-Zaragoza, E., Riquelme-Navarrete, M. J., Sánchez-Zapata, E. and Pérez-Álvarez, J. A. (2010). Resistant starch as functional ingredient: A review. Food Res. Int. 43:931–942.
   Web of Science ®Google Scholar
• González-Montilla, F. M., Chávez-Santoscoy, R. A., Gutiérrez-Uribe, J. A. and Serna-Saldivar, S. O. (2012). Isolation and identification of phase II enzyme inductors obtained from black Shawaya sorghum [Sorghum bicolor (L.) Moench] bran. J. Cereal Sci. 55:126–131.
   Web of Science ®Google Scholar
• Goodall, M. A., Campanella, O. H., Ejeta, G. and Hamaker, B. R. (2012). Grain of high digestible, high lysine (HDHL) sorghum contains kafirins which enhance the protein network of composite dough and bread. J. Cereal Sci. 56:352–357.
   Web of Science ®Google Scholar
• Greenberg, A. S. and Obin, M. S. (2006). Obesity and the role of adipose tissue in inflammation and metabolism. Am. J. Clin. Nutr. 83:461–465.
   PubMed Web of Science ®Google Scholar
• Gregor, M. F. and Hotamisligil, G. S. (2011). Inflammatory mechanisms in obesity. Ann. Rev. Immunol. 29:415–445.
   PubMed Web of Science ®Google Scholar
• Hadbaoui, Z., Djeridane, A., Yousfi, M., Saidi, M. and Nadjemi, B. (2010). Fatty acid, tocopherol composition and the antioxidant activity of the lipid extract from the sorghum grains growing in Algeria. Mediterr. J. Nutr. Met. 3:215–220.
   Google Scholar
• Hagerman, A. E., Riedl, K. M., Jones, G. A., Sovik, K. N., Ritchard, N. T., Hartzfeld, P. W. and Riechel, T. L. (1998). High molecular weight plant polyphenolics (tannins) as biological antioxidants. J. Agric. Food Chem. 46:1887–1892.
   PubMed Web of Science ®Google Scholar
• Hahn, D. and Rooney, L. (1986). Effect of genotype on tannins and phenols of sorghum. Cereal Chem. 63:4–8.
   Web of Science ®Google Scholar
• Hahn, D. H. and Rooney, L. W. (1986). Effect of genotype on tannins and phenols of sorghum. Cereal Chem. J. 63:4–8.
   Web of Science ®Google Scholar
• Hargrove, J. L., Greenspan, P., Hartle, D. K. and Dowd, C. (2011). Inhibition of aromatase and α-amylase by flavonoids and proanthocyanidins from Sorghum bicolor bran extracts. J. Med. Food 14:799–807.
   PubMed Web of Science ®Google Scholar
• Henley, E. C., Taylor, J. R. N. and Obukosia, S. D. (2010). The importance of dietary protein in human health: combating protein deficiency in sub-saharan africa through transgenic biofortified sorghum. In: Advances in Food and Nutrition Research, Vol. 60, pp. 21–52. Steve, L. T. ed., Academic Press.
   Google Scholar
• Hidalgo, M., Oruna-Concha, M. J., Kolida, S., Walton, G. E., Kallithraka, S., Spencer, J. P. E., Gibson, G. R. and de Pascual-Teresa, S. (2012). Metabolism of anthocyanins by human gut microflora and their influence on gut bacterial growth. J. Agric. Food Chem. 60:3882–3890.
   PubMed Web of Science ®Google Scholar
• Hill, H., Slade Lee, L. and Henry, R. J. (2012). Variation in sorghum starch synthesis genes associated with differences in starch phenotype. Food Chem. 131:175–183.
   Web of Science ®Google Scholar
• Hoi, J. T., Weller, C. L., Schlegel, V. L., Cuppett, S. L., Lee, J.-Y. and Carr, T. P. (2009). Sorghum distillers dried grain lipid extract increases cholesterol excretion and decreases plasma and liver cholesterol concentration in hamsters. J. Funct. Foods 1:381–386.
   Web of Science ®Google Scholar
• Hole, A. S., Rud, I., Grimmer, S., Sigl, S., Narvhus, J. and Sahlstrøm, S. (2012). Improved bioavailability of dietary phenolic acids in whole grain barley and oat groat following fermentation with probiotic Lactobacillus acidophilus, Lactobacillus johnsonii, and Lactobacillus reuteri. J. Agric. Food Chem. 60:6369–6375.
   PubMed Web of Science ®Google Scholar
• Holt, R. R., Lazarus, S. A., Sullards, M. C., Zhu, Q. Y., Schramm, D. D., Hammerstone, J. F., Fraga, C. G., Schmitz, H. H. and Keen, C. L. (2002). Procyanidin dimer B2 [epicatechin-(4β-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. Am. J. Clin. Nutr. 76:798–804.
   PubMed Web of Science ®Google Scholar
• Hotamisligil, G. S. (2006). Inflammation and metabolic disorders. Nature 444:860–867.
   PubMed Web of Science ®Google Scholar
• Huang, W.-Y., Cai, Y.-Z. and Zhang, Y. (2009). Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr. Cancer 62:1–20.
   Web of Science ®Google Scholar
• Hwang, J.-M., Choi, K.-C., Bang, S.-J., Son, Y.-O., Kim, B.-T., Kim, D.-H., Choi, G., Kim, D., Shi, X. and Lee, J.-C. (2013). Anti-oxidant and anti-inflammatory properties of methanol extracts from various crops. Food Sci. Biotechnol. 22:265–272.
   Web of Science ®Google Scholar
• Hwang, K. T., Kim, J. E. and Weller, C. L. (2005). Policosanol contents and compositions in wax-like materials extracted from selected cereals of Korean origin. Cereal Chem. 82:242–245.
   Web of Science ®Google Scholar
• Hwang, K. T., Weller, C. L., Cuppett, S. L. and Hanna, M. (2004). Policosanol contents and composition of grain sorghum kernels and dried distillers grains. Biol. Syst. Eng.: Papers Publ. 81:345–349.
   Google Scholar
• Isaacson, C. (2005). The change of the staple diet of black South Africans from sorghum to maize (corn) is the cause of the epidemic of squamous carcinoma of the oesophagus. Med. Hypotheses 64:658–660.
   PubMed Web of Science ®Google Scholar
• Jesch, E. D. and Carr, T. P. (2006). Sitosterol reduces micellar cholesterol solubility in model bile. Nutr. Res. 26:579–584.
   Web of Science ®Google Scholar
• Kamath, V., Niketh, S., Chandrashekar, A. and Rajini, P. S. (2007). Chymotryptic hydrolysates of α-kafirin, the storage protein of sorghum (Sorghum bicolor) exhibited angiotensin converting enzyme inhibitory activity. Food Chem. 100:306–311.
   Web of Science ®Google Scholar
• Kamath, V. G., Chandrashekar, A. and Rajini, P. S. (2004). Antiradical properties of sorghum (Sorghum bicolor L. Moench) flour extracts. J. Cereal Sci. 40:283–288.
   Web of Science ®Google Scholar
• Kangama, C. O. and Rumei, X. (2005). Introduction of sorghum (Sorghum bicolor (L.) Moench) into China. Afr. J. Biotechnol. 4:575–579.
   Web of Science ®Google Scholar
• Kaufman, R. C., Herald, T. J., Bean, S. R., Wilson, J. D. and Tuinstra, M. R. (2013). Variability in tannin content, chemistry and activity in a diverse group of tannin containing sorghum cultivars. J. Sci. Food Agric. 93:1233–1241.
   PubMed Web of Science ®Google Scholar
• Kim, J.-S., Hyun, T. K. and Kim, M.-J. (2011). The inhibitory effects of ethanol extracts from sorghum, foxtail millet and proso millet on α-glucosidase and α-amylase activities. Food Chem. 124:1647–1651.
   Web of Science ®Google Scholar
• Kim, J. and Park, Y. (2012). Anti-diabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats. Nutr. Metabol. 9:1–7.
   Google Scholar
• Kruger, J., Taylor, J. R. N., Du, X., De Moura, F. F., Lönnerdal, B. and Oelofse, A. (2013). Effect of phytate reduction of sorghum, through genetic modification, on iron and zinc availability as assessed by an in vitro dialysability bioaccessibility assay, Caco-2 cell uptake assay, and suckling rat pup absorption model. Food Chem. 141:1019–1025.
   PubMed Web of Science ®Google Scholar
• Kumar, T., Dweikat, I., Sato, S., Ge, Z., Nersesian, N., Chen, H., Elthon, T., Bean, S., Ioerger, B. P., Tilley, M. and Clemente, T. (2012). Modulation of kernel storage proteins in grain sorghum (Sorghum bicolor (L.) Moench). Plant Biotechnol. J. 10:533–544.
   PubMed Web of Science ®Google Scholar
• Lafay, S. and Gil-Izquierdo, A. (2008). Bioavailability of phenolic acids. PhytoChem. Rev. 7:301–311.
   Google Scholar
• Laparra, J. M. and Sanz, Y. (2010). Interactions of gut microbiota with functional food components and nutraceuticals. Pharm. Res. 61:219–225.
   Google Scholar
• Larrosa, M., Yañéz-Gascón, M. a. J., Selma, M. a. V., González-Sarrías, A., Toti, S., Cerón, J. J. n., Tomás-Barberán, F., Dolara, P. and Espín, J. C. (2009). Effect of a low dose of dietary resveratrol on colon microbiota, inflammation and tissue damage in a DSS-induced colitis rat model. J. Agric. Food Chem. 57:2211–2220.
   PubMed Web of Science ®Google Scholar
• Lee, H. C., Jenner, A. M., Low, C. S. and Lee, Y. K. (2006). Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota. Res. Microbiol. 157:876–884.
   PubMed Web of Science ®Google Scholar
• Lee, S., Park, Y., Zuidema, M. Y., Hannink, M. and Zhang, C. (2011). Effects of interventions on oxidative stress and inflammation of cardiovascular diseases. World J. Cardiol. 3:18–24.
   PubMedGoogle Scholar
• Leguizamón, C., Weller, C., Schlegel, V. and Carr, T. (2009). Plant sterol and policosanol characterization of hexane extracts from grain sorghum, corn and their DDGS. J. Am. Oil Chem. Soc. 86:707–716.
   Web of Science ®Google Scholar
• Lewis, J. B. (2008). Effects of Bran from Sorghum Grains Containing Different Classes and Levels of Bioactive Compounds in Colon Carcinogenesis. Texas A&M University, USA.
   Google Scholar
• Manach, C., Williamson, G., Morand, C., Scalbert, A. and Rémésy, C. (2005). Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 81:230S–242S.
   PubMed Web of Science ®Google Scholar
• Margareta Leeman, A., Karlsson, M. E., Eliasson, A.-C. and Björck, I. M. (2006). Resistant starch formation in temperature treated potato starches varying in amylose/amylopectin ratio. Carbohyd. Polym. 65:306–313.
   Web of Science ®Google Scholar
• Marinangeli, C. P. F., Jones, P. J. H., Kassis, A. N. and Eskin, M. N. A. (2010). Policosanols as nutraceuticals: fact or fiction. Crit. Rev. Food Sci. Nutr. 50:259–267.
   PubMed Web of Science ®Google Scholar
• Martínez, I., Kim, J., Duffy, P. R., Schlegel, V. L. and Walter, J. (2010). Resistant starches types 2 and 4 have differential effects on the composition of the fecal microbiota in human subjects. PLoS ONE 5:1–11.
   Web of Science ®Google Scholar
• Martínez, I., Wallace, G., Zhang, C., Legge, R., Benson, A. K., Carr, T. P., Moriyama, E. N. and Walter, J. (2009). Diet-induced metabolic improvements in a hamster model of hypercholesterolemia are strongly linked to alterations of the gut microbiota. Appl. Environ. Microbiol. 75:4175–4184.
   PubMed Web of Science ®Google Scholar
• Martino, H. S. D., Tomaz, P. A., Moraes, E. A., Conceição, L. L., Oliveira, D. S., Queiroz, V. A. V., Rodrigues, J. A. S., Pirozi, M. R., Pinheiro-Sant'Ana, H. M. and Ribeiro, M. R. (2012). Chemical characterization and size distribution of sorghum genotypes for human consumption. Rev. Inst. Adolfo. Lutz. 71:337–344.
   Google Scholar
• Maunder, B. (2005). Sorghum: The global grain of the future. National Grain Sorghum Producers, Lubbock, TX.
   Google Scholar
• McGhie, T. K., Ainge, G. D., Barnett, L. E., Cooney, J. M. and Jensen, D. J. (2003). Anthocyanin glycosides from berry fruit are absorbed and excreted unmetabolized by both humans and rats. J. Agric. Food Chem. 51:4539–4548.
   PubMed Web of Science ®Google Scholar
• Medugu, C., Kwari, I., Igwebuike, J., Nkama, I. and Mohammed, I. (2010). Performance and economics of production of broiler chickens fed sorghum or millet as replacement for maize in the semi-arid zone of Nigeria. Agric. Biol. J. North. Am. 1:321–325.
   Google Scholar
• Mehlo, L., Mbambo, Z., Bado, S., Lin, J., Moagi, S. M., Buthelezi, S., Stoychev, S. and Chikwamba, R. (2013). Induced protein polymorphisms and nutritional quality of gamma irradiation mutants of sorghum. Mutation Res./λατνϵμαδνυΦ σισϵνϵγατυμ φο σμσιναηχϵμ ραλυχϵλομ δνα 195:642–732.
   Google Scholar
• Mehmood, S., Orhan, I., Ahsan, Z., Aslan, S. and Gulfraz, M. (2008). Fatty acid composition of seed oil of different Sorghum bicolor varieties. Food Chem. 109:855–859.
   PubMed Web of Science ®Google Scholar
• Mkandawire, N. L., Kaufman, R. C., Bean, S. R., Weller, C. L., Jackson, D. S. and Rose, D. J. (2013). Effects of sorghum (Sorghum bicolor (L.) Moench) tannins on α-amylase activity and in vitro digestibility of starch in raw and processed flours. J. Agric. Food Chem. 61:4448–4454.
   PubMed Web of Science ®Google Scholar
• Mokrane, H., Amoura, H., Belhaneche-Bensemra, N., Courtin, C. M., Delcour, J. A. and Nadjemi, B. (2010). Assessment of Algerian sorghum protein quality [Sorghum bicolor (L.) Moench] using amino acid analysis and in vitro pepsin digestibility. Food Chem. 121:719–723.
   Web of Science ®Google Scholar
• Moraes, É. A., Natal, D. I. G., Queiroz, V. A. V., Schaffert, R. E., Cecon, P. R., de Paula, S. O., Benjamim, L. d. A., Ribeiro, S. M. R. and Martino, H. S. D. (2012a). Sorghum genotype may reduce low-grade inflammatory response and oxidative stress and maintains jejunum morphology of rats fed a hyperlipidic diet. Food Res. Int. 49:553–559.
   Web of Science ®Google Scholar
• Moraes, É. A., Queiroz, V. A. V., Shaffert, R. E., Costa, N. M. B., Nelson, J. D., Ribeiro, S. M. R. and Martino, H. S. D. (2012b). In vivo protein quality of new sorghum genotypes for human consumption. Food Chem. 134:1549–1555.
   PubMed Web of Science ®Google Scholar
• Muriu, J. I., Njoka-Njiru, E. N., Tuitoek, J. K. and Nanua, J. N. (2002). Evaluation of sorghum (Sorghum bicolor) as replacement for maize in the diet of growing rabbits (Oryctolagus cuniculus). Asian-Aust. J. Animal Sci. 15:565–569.
   Web of Science ®Google Scholar
• N'Dri, D., Mazzeo, T., Zaupa, M., Ferracane, R., Fogliano, V. and Pellegrini, N. (2013). Effect of cooking on the total antioxidant capacity and phenolic profile of some whole-meal African cereals. J. Sci. Food Agr. 93:29–36.
   PubMed Web of Science ®Google Scholar
• Neucere, J. N. (1982). Lectins in grain sorghum [Sorghum bicolor (L.) Moench]. J. Agr. Food Chem. 30:603–604.
   PubMed Web of Science ®Google Scholar
• Nyamambi, B., Ndlovu, L. R., Read, J. S. and Reed, J. D. (2000). The effects of sorghum proanthocyanidins on digestive enzyme activity in vitro and in the digestive tract of chicken. J. Sci. Food Agric. 80:2223–2231.
   Web of Science ®Google Scholar
• Ochanda, S. O., Onyango, C., Mwasaru, A., Ochieng, J. and Mathooko, F. (2010). Effects of malting and fermentation treatments on group B-vitamins of red sorghum, white sorghum and pearl millets in Kenya. J. Appl. Biosci. 34:2128–2134.
   Google Scholar
• Oria, M. P., Hamaker, B. R., Axtell, J. D. and Huang, C.-P. (2000). A highly digestible sorghum mutant cultivar exhibits a unique folded structure of endosperm protein bodies. Proc. Natl. Acad. Sci. USA 97:5065–5070.
   PubMed Web of Science ®Google Scholar
• Osman, M. A. (2004). Changes in sorghum enzyme inhibitors, phytic acid, tannins and in vitro protein digestibility occurring during Khamir (local bread) fermentation. Food Chem. 88:129–134.
   Web of Science ®Google Scholar
• Park, J. H., Darvin, P., Lim, E. J., Joung, Y. H., Hong, D. Y., Park, E. U., Park, S. H., Choi, S. K., Moon, E.-S., Cho, B. W., Park, K. D., Lee, H. K., Kim, M.-J., Park, D.-S., Chung, I.-M. and Yang, Y. M. (2012). Hwanggeumchal sorghum induces cell cycle arrest, and suppresses tumor growth and metastasis through Jak2/STAT pathways in breast cancer xenografts. PLoS ONE 7:40531–40531.
   PubMed Web of Science ®Google Scholar
• Park, J. H., Lee, S. H., Chung, I.-M. and Park, Y. (2012). Sorghum extract exerts an anti-diabetic effect by improving insulin sensitivity via PPAR-γ in mice fed a high-fat diet. Nutr. Res. Pract. 6:322–327.
   PubMed Web of Science ®Google Scholar
• Pontieri, P., Mamone, G., De Caro, S., Tuinstra, M. R., Roemer, E., Okot, J., De Vita, P., Ficco, D. B. M., Alifano, P., Pignone, D., Massardo, D. R. and Del Giudice, L. (2013). Sorghum, a healthy and gluten-free food for celiac patients as demonstrated by genome, biochemical, and immunochemical analyses. J. Agric. Food Chem. 61:2565–2571.
   PubMed Web of Science ®Google Scholar
• Pranoto, Y., Anggrahini, S. and Efendi, Z. (2013). Effect of natural and Lactobacillus plantarum fermentation on in-vitro protein and starch digestibilities of sorghum flour. Food BioSci. 2:46–52
   Google Scholar
• Price, M. L., Van Scoyoc, S. and Butler, L. G. (1978). A critical evaluation of the vanillin reaction as an assay for tannin in sorghum grain. J. Agric. Food Chem. 26:1214–1218.
   Web of Science ®Google Scholar
• Prior, R. L. and Wu, X. (2006). Anthocyanins: structural characteristics that result in unique metabolic patterns and biological activities. Free Radical Res. 40:1014–1028.
   PubMed Web of Science ®Google Scholar
• Ragaee, S., Abdel-Aal, E.-S. M. and Noaman, M. (2006). Antioxidant activity and nutrient composition of selected cereals for food use. Food Chem. 98:32–38.
   Web of Science ®Google Scholar
• Rahman, I. E. A. and Osman, M. A. W. (2011). Effect of sorghum type (Sorghum bicolor) and traditional fermentation on tannins and phytic acid contents and trypsin inhibitor activity. J. Food Agric. Environ. 9:163–166.
   Web of Science ®Google Scholar
• Raimi, O., Olaitan, S., Fajana, O. and Sanni, J. (2012). Effect of germination time on fat and protein contents, and α-amylase activity of Guinea Corn (Sorghum vulgare). Pakistan J. Food Sci. 22:86–89.
   Google Scholar
• Requena, T., Monagas, M., Pozo-Bayón, M. A., Martín-Álvarez, P. J., Bartolomé, B., del Campo, R., Ávila, M., Martínez-Cuesta, M. C., Peláez, C. and Moreno-Arribas, M. V. (2010). Perspectives of the potential implications of wine polyphenols on human oral and gut microbiota. Trend Food Sci. Technol. 21:332–344.
   Web of Science ®Google Scholar
• Rooney, L. and Pflugfelder, R. (1986). Factors affecting starch digestibility with special emphasis on sorghum and corn. J. Animal Sci. 63:1607–1623.
   Web of Science ®Google Scholar
• Sang, Y., Bean, S., Seib, P. A., Pedersen, J. and Shi, Y.-C. (2008). Structure and functional properties of sorghum starches differing in amylose content. J. Agric. Food Chem. 56:6680–6685.
   PubMed Web of Science ®Google Scholar
• Saura-Calixto, F. (2010). Dietary Fiber as a Carrier of Dietary Antioxidants: An Essential Physiological Function. J. Agric. Food Chem. 59:43–49.
   PubMed Web of Science ®Google Scholar
• Schober, T. J., Messerschmidt, M., Bean, S. R., Park, S.-H. and Arendt, E. K. (2005). Gluten-free bread from sorghum: quality differences among hybrids. Cereal Chem. J. 82:394–404.
   Web of Science ®Google Scholar
• Schons, P. F., Ries, E. F., Battestin, V. and Macedo, G. A. (2011). Effect of enzymatic treatment on tannins and phytate in sorghum (Sorghum bicolor) and its nutritional study in rats. Int. J. Food Sci. Technol. 46:1253–1258.
   Web of Science ®Google Scholar
• Scott, K. P., Duncan, S. H. and Flint, H. J. (2008). Dietary fibre and the gut microbiota. Nutr. Bull. 33:201–211.
   Google Scholar
• Selma, M. a. V., Espín, J. C. and Tomás-Barberán, F. A. (2009). Interaction between phenolics and gut microbiota: role in human health. J. Agric. Food Chem. 57:6485–6501.
   PubMed Web of Science ®Google Scholar
• Serrano, J., Puupponen‐Pimiä, R., Dauer, A., Aura, A. M. and Saura-Calixto, F. (2009). Tannins: current knowledge of food sources, intake, bioavailability and biological effects. Mol. Nutr. Food Res. 53:310–329.
   PubMed Web of Science ®Google Scholar
• Sharma, S., Kelly, T. K. and Jones, P. A. (2010). Epigenetics in cancer. Carcinogenesis 31:27–36.
   PubMed Web of Science ®Google Scholar
• Sharma, S. D., Meeran, S. M. and Katiyar, S. K. (2007). Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-κB signaling in in vivo SKH-1 hairless mice. Mol. Cancer Ther. 6:995–1005.
   PubMed Web of Science ®Google Scholar
• Shegro, A., Shargie, N., Biljon, A. and Labuschagne, M. (2012). Diversity in starch, protein and mineral composition of sorghum landrace accessions from Ethiopia. J. Crop Sci. Biotechnol. 15:275–280.
   Google Scholar
• Shewry, P. R. (2007). Improving the protein content and composition of cereal grain. J. Cereal Sci. 46:239–250.
   Web of Science ®Google Scholar
• Shih, C.-H., Siu Ng, R., Wong, E., Chiu, L. C. M., Chu, I. K. and Lo, C. (2007). Quantitative analysis of anticancer 3-deoxyanthocyanidins in infected sorghum seedlings. J. Agric. Food Chem. 55:254–259.
   PubMed Web of Science ®Google Scholar
• Shih, P.-H., Yeh, C.-T. and Yen, G.-C. (2007). Anthocyanins induce the activation of phase ii enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis. J. Agric. Food Chem. 55:9427–9435.
   PubMed Web of Science ®Google Scholar
• Shim, T., Kim, T., Jang, K., Ko, J. and Kim, D. (2013). Toxicological evaluation and anti-inflammatory activity of a golden gelatinous sorghum bran extract. Biosci. Biotechnol. Biochem. 77:697–705.
   PubMed Web of Science ®Google Scholar
• Silva, C. S. d., Queiroz, V. A. V., Simeone, M. L. F., Guimarães, C. d. C., Schaffert, R. E., Rodrigues, J. A. S. and Miguel, R. d. A. (2012). Teores de minerais em linhagens de sorgo para uso na alimentação humana. In XXIX Congresso Nacional de Milho e Sorgo, (pp.2776–2782). Água de Lindóia.
   Google Scholar
• Singh, H., Sodhi, N. S. and Singh, N. (2010). Characterisation of starches separated from sorghum cultivars grown in India. Food Chem. 119:95–100.
   Web of Science ®Google Scholar
• Singh, V., Moreau, R. A. and Hicks, K. B. (2003). Yield and phytosterol composition of oil extracted from grain sorghum and its wet-milled fractions. Cereal Chem. J. 80:126–129.
   Web of Science ®Google Scholar
• Slavin, J. (2004). Whole grains and human health. Nutr. Res. Rev. 17:99–110.
   PubMed Web of Science ®Google Scholar
• Spencer, J. P. and Crozier, A. (2012). Flavanoids and Related Compounds: Bioavailability and Function (Vol. 29): CRC Press, Boca Raton, FL, USA.
   Google Scholar
• Suganyadevia, P., Saravanakumara, K. M. and Mohandasb, S. (2011a). Evaluation of antiproliferative activity of red sorghum bran anthocyanin on a human breast cancer cell line (MCF-7). Int. J. Breast Cancer 2011:1–6.
   Google Scholar
• Suganyadevia, P., Saravanakumara, K. M. and Mohandasb, S. (2011b). Identification of 3- deoxyanthocyanins from red sorghum (Sorghum bicolor) bran and its biological properties. Afr. J. Pure Appl. Chem. 5:181–193.
   Google Scholar
• Suganyadevia, P., Saravanakumara, K. M. and Mohandasb, S. (2013). The antiproliferative activity of 3-deoxyanthocyanins extracted from red sorghum (Sorghum bicolor) bran through P53-dependent and Bcl-2 gene expression in breast cancer cell line. Life Sci. 92:379–382.
   PubMed Web of Science ®Google Scholar
• Svensson, L., Sekwati-Monang, B., Lutz, D. L., Schieber, A. and Gänzle, M. G. (2010). Phenolic acids and flavonoids in nonfermented and fermented red sorghum (Sorghum bicolor (L.) Moench). J. Agric. Food Chem. 58:9214–9220.
   PubMed Web of Science ®Google Scholar
• Takabe, W., Matsukawa, N., Kodama, T., Tanaka, K. and Noguchi, N. (2006). Chemical structure–dependent gene expression of proteasome subunits via regulation of the antioxidant response element. Free Radical Res. 40:21–30.
   PubMed Web of Science ®Google Scholar
• Taleon, V., Dykes, L., Rooney, W. L. and Rooney, L. W. (2012). Effect of genotype and environment on flavonoid concentration and profile of black sorghum grains. J. Cereal Sci. 56:470–475.
   Web of Science ®Google Scholar
• Taylor, J., Bean, S. R., Ioerger, B. P. and Taylor, J. R. N. (2007). Preferential binding of sorghum tannins with γ-kafirin and the influence of tannin binding on kafirin digestibility and biodegradation. J. Am. Coll. Nutr. 46:22–31.
   Google Scholar
• Taylor, J. and Taylor, J. R. N. (2011). Protein biofortified sorghum: effect of processing into traditional African foods on their protein quality. J. Agric. Food Chem. 59:2386–2392.
   PubMed Web of Science ®Google Scholar
• Taylor, J. R. N., Belton, P. S., Beta, T. and Duodu, K. G. (2014). Increasing the utilisation of sorghum, millets and pseudocereals: Developments in the science of their phenolic phytochemicals, biofortification and protein functionality. J. Cereal Sci. 59:257–275.
   Web of Science ®Google Scholar
• Taylor, J. R. N. and Emmambux, M. (2010). Developments in our understanding of sorghum polysaccharides and their health benefits. Cereal Chem. 87:263–271.
   Web of Science ®Google Scholar
• Towo, E., Matuschek, E. and Svanberg, U. (2006). Fermentation and enzyme treatment of tannin sorghum gruels: effects on phenolic compounds, phytate and in vitro accessible iron. Food Chem. 94:369–376.
   Web of Science ®Google Scholar
• Tripathi, B., Chetana,   and Platel, K. (2010). Fortification of sorghum (Sorghum vulgare) and pearl millet (Pennisetum glaucum) flour with zinc. J. Trace Elem. Med. Biol. 24:257–262.
   PubMed Web of Science ®Google Scholar
• Tripathi, B. and Platel, K. (2013). Feasibility in fortification of sorghum (Sorghum bicolor L. Moench) and pearl millet (Pennisetum glaucum) flour with iron. LWT—Food Sci. Technol. 50:220–225.
   Web of Science ®Google Scholar
• Tzounis, X., Rodriguez-Mateos, A., Vulevic, J., Gibson, G. R., Kwik-Uribe, C. and Spencer, J. P. (2011). Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. Am. J. Clin. Nutr. 93:62–72.
   PubMed Web of Science ®Google Scholar
• U.S. Department of Agriculture, A. R. S. (2012). USDA National Nutrient Database for Standard Reference (25th ed.). Washington, DC.
   Google Scholar
• U.S. Grains Council. (2004). Sorghum Handbook: White Sorghum, the New Food Grain. U.S. Grains Council, Washington, DC.
   Google Scholar
• Udachan, I. S., Sahu, A. K. and Hend, F. M. (2012). Extraction and characterization of sorghum (Sorghum bicolor L. Moench) starch. Int. Food Res. J. 19:315–319.
   Google Scholar
• Urpi-Sarda, M., Rothwell, J., Morand, C. and Manach, C. (2012). Bioavailability of flavanones. In: Flavanoids and Related Compounds: Bioavailability and Function, pp. 1–44. Spencer, J. P. E. and Crozier, A., Eds., CRC Press, London, U.K.
   Google Scholar
• Wang, L., Weller, C. L., Schlegel, V. L., Carr, T. P. and Cuppett, S. L. (2007). Comparison of supercritical CO2 and hexane extraction of lipids from sorghum distillers grains. Eur. J. Lipid Sci. Technol. 109:567–574.
   Web of Science ®Google Scholar
• Wang, L., Weller, C. L., Schlegel, V. L., Carr, T. P. and Cuppett, S. L. (2008). Supercritical CO2 extraction of lipids from grain sorghum dried distillers grains with solubles. Bioresource Technol. 99:1373–1382.
   PubMed Web of Science ®Google Scholar
• Waniska, R. D. and Rooney, L. W. (2000). Structure and chemistry of the sorghum caryopsis. In: Sorghum: Production, Agronomy, Chemistry and Utilization, pp. 649–688. Smith, W. and Frederiksen, R. A., eds., Wiley & Sons, New York.
   Google Scholar
• Wedad, H. A., El Tinay, A. H., Mustafa, A. I. and Babiker, E. E. (2008). Effect of fermentation, malt-pretreatment and cooking on antinutritional factors and protein digestibility of sorghum cultivars. Pakistan J. Nutr. 7:335–341.
   Google Scholar
• Williamson, G. and Clifford, M. N. (2010). Colonic metabolites of berry polyphenols: the missing link to biological activity? Br. J. Nutr. 104:48–66.
   PubMed Web of Science ®Google Scholar
• Wong, J. H., Lau, T., Cai, N., Singh, J., Pedersen, J. F., Vensel, W. H., Hurkman, W. J., Wilson, J. D., Lemaux, P. G. and Buchanan, B. B. (2009). Digestibility of protein and starch from sorghum (Sorghum bicolor) is linked to biochemical and structural features of grain endosperm. J. Cereal Sci. 49:73–82.
   Web of Science ®Google Scholar
• Woo, H. J., Oh, I. T., Lee, J. Y., Jun, D. Y., Seu, M. C., Woo, K. S., Nam, M. H. and Kim, Y. H. (2012). Apigeninidin induces apoptosis through activation of Bak and Bax and subsequent mediation of mitochondrial damage in human promyelocytic leukemia HL-60 cells. Process BioChem. 47:1861–1871.
   Web of Science ®Google Scholar
• Woodward, G., Kroon, P., Cassidy, A. and Kay, C. (2009). Anthocyanin stability and recovery: implications for the analysis of clinical and experimental samples. J. Agric. Food Chem. 57:5271–5278.
   PubMed Web of Science ®Google Scholar
• Wu, X., Pittman, H. E., Mckay, S. and Prior, R. L. (2005). Aglycones and sugar moieties alter anthocyanin absorption and metabolism after berry consumption in weanling pigs. J. Nutr. 135:2417–2424.
   PubMed Web of Science ®Google Scholar
• Wu, X. and Prior, R. L. (2005). Identification and characterization of anthocyanins by high-performance liquid chromatography—electrospray ionization—tandem mass spectrometry in common foods in the United States: vegetables, nuts, and grains. J. Agric. Food Chem. 53:3101–3113.
   PubMed Web of Science ®Google Scholar
• Wu, Y., Li, X., Xiang, W., Zhu, C., Lin, Z., Wu, Y., Li, J., Pandravada, S., Ridder, D. D., Bai, G., Wang, M. L., Trick, H. N., Bean, S. R., Tuinstra, M. R., Tesso, T. T. and Yu, J. (2012). Presence of tannins in sorghum grains is conditioned by different natural alleles of Tannin1. Proc. Natl. Acad. Sci. USA 109:10281–10286.
   Google Scholar
• Wu, Y., Yuan, L., Guo, X., Holding, D. R. and Messing, J. (2013). Mutation in the seed storage protein kafirin creates a high-value food trait in sorghum. Nature Commun. 4.
   Web of Science ®Google Scholar
• Yamagishi, S.-i. (2011). Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes. Exp. Gerontol. 46:217–224.
   PubMed Web of Science ®Google Scholar
• Yang, L., Allred, K. F., Geera, B., Allred, C. D. and Awika, J. M. (2012). Sorghum phenolics demonstrate estrogenic action and Induce apoptosis in nonmalignant colonocytes. Nutr. Cancer 64:419–427.
   PubMed Web of Science ®Google Scholar
• Yang, L., Browning, J. D. and Awika, J. M. (2009). Sorghum 3-deoxyanthocyanins possess strong phase II enzyme inducer activity and cancer cell growth inhibition properties. J. Agric. Food Chem. 57:1797–1804.
   PubMed Web of Science ®Google Scholar
• Yang, M., I Koo, S., O Song, W. and K Chun, O. (2011). Food matrix affecting anthocyanin bioavailability: review. Curr. Med. Chem. 18:291–300.
   PubMed Web of Science ®Google Scholar
• Ye, J.-C., Chang, W.-C., Hsieh, D. J.-Y. and Hsiao, M.-W. (2010). Extraction and analysis of β-sitosterol in herbal medicines. J. Med. Plants Res. 7:522–527.
   Google Scholar
• Zbasnik, R., Carr, T., Weller, C., Hwang, K. T., Wang, L., Cuppett, S. and Schlegel, V. (2009). Antiproliferation properties of grain sorghum dry distiller's grain lipids in caco. J. Agric. Food Chem. 57:10435–10441.
   PubMed Web of Science ®Google Scholar