Herbal medicines and chemotherapy induced peripheral neuropathy (CIPN): A critical literature review

References

• Abad, A. N. A., Nouri, M. H. K., Gharjanie, A., and Tavakoli, F. (2011a). Effect of matricaria chamomilla hydroalcoholic extract on cisplatin-induced neuropathy in mice. Chinese J. Nat. Med. 9(2):126–131.
   Google Scholar
• Abad, A. N. A., Nouri, M. H. K, and Tavakkolia, F. (2011b). Effect of salvia officinalis hydroalcoholic extract on vincristine-induced neuropathy in mice. Chin J. Nat. Med. 9(5):354–358.
   Google Scholar
• Ahlemeyer, B. and Krieglstein, J. (2003). Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry. 36(1):8–14.
   Google Scholar
• Al Moundhri, M. S., Al-Salam, S., Al Mahrouqee, A., Beegam, S., and Ali, B. H. (2013). The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats: some behavioral, biochemical, and histopathological studies. J. Med. Toxicol. 9(1):25–33.
   PubMedGoogle Scholar
• Argyriou, A. A., Chroni, E., Koutras, A., Ellul, J., Papapetropoulos, S., Katsoulas, G., Iconomou, G., and Kalofonos, H. P. (2005). Vitamin E for prophylaxis against chemotherapy-induced neuropathy: A randomized controlled trial. Neurology. 64(1):26–31.
   PubMed Web of Science ®Google Scholar
• Argyriou, A. A., Chroni, E., Koutras, A., Iconomou, G., Papapetropoulos, S., Polychronopoulos, P., and Kalofonos, H. P. (2006). A randomized controlled trial evaluating the efficacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: final results. Support Care Cancer. 14(11):1134–1140.
   PubMed Web of Science ®Google Scholar
• Argyriou, A. A., and Kalofonos, H. P. (2011). Vitamin E for preventing chemotherapy-induced peripheral neuropathy. Support Care Cancer. 19(5):725–726.
   PubMed Web of Science ®Google Scholar
• Armstrong, T., Almadrones, L., and Gilbert, M. R. (2005). Chemotherapy-induced peripheral neuropathy. Oncol. Nurs. Forum. 32(2):305–311.
   PubMed Web of Science ®Google Scholar
• Bahar, A. M., Andoh, T., Ogura, K., Hayakawa, Y., Saiki, I., and Kuraishi, Y. (2013). Herbal medicine goshajinkigan prevents paclitaxel-induced mechanical allodynia without impairing antitumor activity of paclitaxel. Evid. Based Compl. Alternative Medicine. Dx.doi.org/10.1155/2013/849754
   PubMed Web of Science ®Google Scholar
• Berry, M. (1995). The chamomiles. Pharma. J. 254:191–193.
   Google Scholar
• Bhagra, A., and Rao, R. D. (2007). Chemotherapy-induced neuropathy. Curr. Oncol. Rep. 9(4):290–299.
   PubMedGoogle Scholar
• Biesbroeck, R., Bril, V., Hollander, P., Kabadi, U., Schwartz, S., Singh, S. P., Ward, W. K., and Bernstein, J. E. (1995). A double-blind comparison of topical capsaicin and oral amitriptyline in painful diabetic neuropathy. Adv. Ther. 12(2):111–120.
   PubMed Web of Science ®Google Scholar
• Brown, S., Simpson, D. M., Moyle, G., Brew, B. J., Schifitto, G., Larbalestier, N., Orkin, C., Fisher, M., Vanhove, G. F., and Tobias, J. K. (2013). NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials. AIDS Res. Ther. 10(1):5. Doi: 10.1186/1742-6405-10-5.
   PubMed Web of Science ®Google Scholar
• Cakil, B., Basar, F. S., Atmaca, S., Cengel, S. K., Tekat, A., and Tanyeri, Y. (2012). The protective effect of Ginkgo biloba extract against experimental cisplatin ototoxicity: animal research using distortion product otoacoustic emissions. J. Laryngol. Otol. 126(11):1097–1101.
   PubMed Web of Science ®Google Scholar
• Cavaletti, G., and Marmiroli, P. (2004). Chemotherapy-induced peripheral neurotoxicity. Expert. Opin. Drug. Saf. 3(6):535–546.
   PubMedGoogle Scholar
• Cavaletti, G., Nicolini, G., and Marmiroli, P. (2008). Neurotoxic effects of antineoplastic drugs: the lesson of pre-clinical studies. Front Biosci. 13:3506–3524.
   PubMed Web of Science ®Google Scholar
• Cavaletti, G., Alberti, P., Frigeni, B., Piatti, M., and Susani, E. (2011). Chemotherapy-induced neuropathy. Curr. Treat Opt. Neurol. 13(2):180–190.
   PubMed Web of Science ®Google Scholar
• Chad, D. A., Aronin, N., Lundstrom, R., McKeon, P., Ross, D., Molitch, M., Schipper, H. M., Stall, G., Dyess, E., and Tarsy, D. (1990). Does capsaicin relieve the pain of diabetic neuropathy? Pain. 42(3):387–388.
   PubMed Web of Science ®Google Scholar
• Choi, Y. C., Kwon, K. R., and Choi, S. H. (2006). Purification of peptide components including melittin from bee venom using gel filtration chromotography and propionic acid/urea polyacrylamide gel electrophoresis. J. Korean Pharmacoacupun. Inst. 9:105–112.
   Google Scholar
• Clifford, D. B., Simpson, D. M., Brown, S., Moyle, G., Brew, B. J., Conway, B., Tobias, J. K., Vanhove, G. F.; NGX-4010 C119 Study Group. (2012). A randomized, double-blind, controlled study of NGX-4010, a capsaicin 8% dermal patch, for the treatment of painful HIV-associated distal sensory polyneuropathy. J. Acquir. Immune Defic. Syndr. 59(2):126–133.
   PubMed Web of Science ®Google Scholar
• Coleman, M. P., Forman, D., Bryant, H., Butler, J., Rachet, B., Maringe, C., Nur, U., Tracey, E., Coory, M., Hatcher, J., McGahan, C. E., Turner, D., Marrett, L., Gjerstorff, M. L., Johannesen, T. B., Adolfsson, J., Lambe, M., Lawrence, G., Meechan, D., Morris, E. J., Middleton, R., Steward, J., Richards, M. A., and the and I.M.W. Group*. Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995–2007 (the International Cancer Benchmarking Partnership). (2011). An analysis of population-based cancer registry data. Lancet. 377(9760):127–138.
   PubMed Web of Science ®Google Scholar
• Deng, J. H., and Zou, S. L. (2007). Observation on TCM treatment of 32 cases of chemotherapy-induced peripheral neuropathy. J. Pract. Trad. Chin. Int. Med. 21:2.
   Google Scholar
• Ferrier, J., Pereira, V., Busserolles, J., Authier, N., and Balayssac, D. (2013). Emerging trends in understanding chemotherapy-induced peripheral neuropathy. Curr. Pain Headache Rep. 17(10):364.
   PubMed Web of Science ®Google Scholar
• Fujii, K., Okamoto, S., Saitoh, K., Sasaki, N., Takano, M., Tanaka, S., Kudoh, K., Kita, T., Tode, T., and Kikuchi, Y. (2004). The efficacy of Shakuyaku-Kanzo-to for peripheral nerve dysfunction in paclitaxel combination chemotherapy for epithelial ovarian carcinoma. Gan To Kagaku Ryoho. 31(10):1537–1540.
   PubMedGoogle Scholar
• Ghoreishi, Z., E.A., Djazayeri, A., Djalali, M., Golestan, B., Ayromlou, H., Hashemzade, S., Asghari Jafarabadi M, Montazeri, V., Keshavarz, S. A., and Darabi, M. (2012). Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: A randomised double-blind placebo controlled trial. BMC Cancer. 12:355.
   PubMed Web of Science ®Google Scholar
• Hashimoto, K., Sakuma, Y., and Kotani, J. (2004). Histological study of a paclitaxel-induced peripheral neuropathy model treated with goshajinkigan. J. Osaka Dental Univ. 38(2):109–112.
   Google Scholar
• Hashimoto, K., Sakuma, Y., and Kotani, J. (2006). Goshajinkigan improves paclitaxel-induced peripheral neuropathy without affecting anti-tumour efficacy in rodents. J. Osaka Dental Univ. 40(1):47–52.
   Google Scholar
• Hidaka, T., Shima, T., Nagira, K., Ieki, M., Nakamura, T., Aono, Y., Kuraishi, Y., Arai, T., and Saito, S. (2009). Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice. Eur. J. Pain. 13(1):22–27.
   PubMed Web of Science ®Google Scholar
• Hosokawa, A., Ogawa, K., Ando, T., Suzuki, N., Ueda, A., Kajiura, S., Kobayashi, Y., Tsukioka, Y., Horikawa, N., Yabushita, K., Fukuoka, J., and Sugiyama, T. (2012). Preventative effect of traditional Japanese medicine on neurotoxicity of FOLFOX for metastatic colorectal cancer: A multicentre retrospective study. Ant. Res. 32(7):2545–2550.
   Google Scholar
• Howes, M. J., Perry, N. S., and Houghton, P. J. (2003). Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytother Res. 17(1):1–18.
   PubMed Web of Science ®Google Scholar
• Huang, X., Whitworth, C. A., and Rybak, L. P. (2007). Ginkgo biloba extract (Egb 761) protects against cisplatin-induced ototoxicity in rats. Otol. Neurotol. 28(6):828–833.
   PubMed Web of Science ®Google Scholar
• Japan Society of Oriental Medicine. (2005). Introduction of Kampo. Japanese Traditional Medicine. Elsevier, Tokyo, Japan.
   Google Scholar
• Kaku, H., Kumagai, S., Onoue, H., Takada, A., Shoji, T., Miura, F., Yoshizaki, A., Sato, S., Kigawa, J., Arai, T., Tsunoda, S., Tominaga, E., Aoki, D., and Sugiyama, T. (2012). Objective evaluation of the alleviating effects of Goshajinkigan on peripheral neuropathy induced by paclitaxel/carboplatin therapy: A multicentre collaborative study. Exp. Therapeut. Med. 3(1):60–65.
   PubMed Web of Science ®Google Scholar
• Kaley, T. J., and Deangelis, L. M. (2009). Therapy of chemotherapy-induced peripheral neuropathy. Br. J. Haematol. 145(1):3–14.
   PubMed Web of Science ®Google Scholar
• Kono, T., Mamiya, N., Chisato, N., Ebisawa, Y., Yamazaki, H., Watari, J., Yamamoto, Y., Suzuki, S., Asama, T., and Kamiya, K. (2011). Efficacy of Goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer. Evid. Based Complement. Alternat. Med. (418481):8.
   Google Scholar
• Kono, T., Hata, T., Morita, S., Munemoto, Y., Matsui, T., Kojima, H., Takemoto, H., Fukunaga, M., Nagata, N., Shimada, M., Sakamoto, J., and Mishima, H. (2013). Goshajinkigan oxaliplatin neurotoxicity evaluation (GONE): a phase 2, multicenter, randomized, double-blind, placebo-controlled trial of goshajinkigan to prevent oxaliplatin-induced neuropathy. Cancer Chemother. Pharmacol. October 72(6):1283–1290.
   PubMed Web of Science ®Google Scholar
• Kwon, K. R., Choi, S. H., and Cha, B. C. (2006). Component analysis of sweet BV and clinical trial on antibody titer and allergic reactions. J. Korean Pharmacoacupun. Inst. 9:79–86.
   Google Scholar
• Lee, J. S., Lee, J. Y., Kwon, K. R., and Lee, H. C. (2006). A study on allergic response between bee venom and sweet bee venom pharmacopuncture. J. Korean Pharmacoacupun. Inst. 9:61–77.
   Google Scholar
• Li, H. J., Jiang, Y., and Li, P. (2006). Chemistry, bioactivity and geographical diversity of steroidal alkaloids from the Liliaceae family. Nat. Prod. Rep. 23(5):735–752.
   PubMed Web of Science ®Google Scholar
• Lim, B. S., Moon, H., Li, D. X., Gil, M., Min, J. K., Lee, G., Bae, H., Kim, S. K., and Min, B. I. (2013). Effect of Bee venom acupuncture on oxaliplatin-induced cold allodynia in rats. Evid. Based Complement. Alternat. Med. 2013:369324.
   Web of Science ®Google Scholar
• Low, P. A., Opfer-Gehrking, T. L., Dyck, P. J., Litchy, W. J., and O'Brien, P. C. (1995). Double-blind, placebo-controlled study of the application of capsaicin cream in chronic distal painful polyneuropathy. Pain. 62(2):163–168.
   PubMed Web of Science ®Google Scholar
• Marshall, J., Zakari, A., Hwang, J. J., Papadopoulos, V., Rosenberg, A., Silver, C. (2004). Ginkgo Biloba (GB) extract as a neuroprotective agent in oxaliplatin (Ox)-induced neuropathy. American Society of Clinical Oncologists Annual Meeting Proceedings. J. Clin. Oncol. 22(14) abstract 3670
   Web of Science ®Google Scholar
• Mills, S. (1991). The Essential Book of Herbal Medicine. 2nd ed. Penguin Books Ltd., London
   Google Scholar
• Muthuraman, A., Singh, N., and Jaggi, A. S. (2011). Protective effect of Acorus calamus L. in rat model of vincristine induced painful neuropathy: An evidence of anti-inflammatory and anti-oxidative activity. Food Chem. Toxicol. 49(10):2557–2563.
   PubMed Web of Science ®Google Scholar
• NHMRC. (2009). National Health and Medical Research Council. NHMRC additional levels of evidence and grades for recommendations for developers of guidelines. Co., Australia.
   Google Scholar
• Nishioka, M., Shimada, M., Kurita, N., Iwata, T., Morimoto, S., Yoshikawa, K., Higashijima, J., Miyatani, T., and Kono, T. (2011). The Kampo medicine, Goshajinkigan, prevents neuropathy in patients treated by FOLFOX regimen. Int. J. Clin. Onc. 16(4):322–327.
   PubMed Web of Science ®Google Scholar
• No authors listed. (1991). Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle-controlled study. The Capsaicin Study Group. Arch. Intern. Med. 151(11):2225–2229.
   PubMedGoogle Scholar
• Oh, H., Kang, D. G., Lee, S., Lee, Y., and Lee, H. S. (2003). Angiotensin converting enzyme (ACE) inhibitory alkaloids from Fritillaria ussuriensis. Planta Med. 69(6):564–565.
   PubMed Web of Science ®Google Scholar
• Oztürk, G., Anlar, O., Erdoğan, E., Kösem, M., Ozbek, H., and Türker, A. (2004). The effect of Ginkgo extract Egb761 in cisplatin-induced peripheral neuropathy in mice. Toxicol. Appl. Pharmacol. 196(1):169–175.
   PubMed Web of Science ®Google Scholar
• Pace, A., Antonella, S., Mauro, P., Vittoria, M., Umberto, P., Girolamo Del, M., Annamaria, B., Carlo, L., Bruno, J., Francesco, C., and Loredana, B. (2003). Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy. Source J. Clin. Oncol. 21(5):927–931.
   PubMed Web of Science ®Google Scholar
• Pace, A., Giannarelli, D., Galie, E., Savarese, A., Carpano, S., Della Giula, M., Pozzi, A., Silvani, A., Gaviani, P., Scaioli, V., Jandolo, B., Bove, L., and Cognett, F. (2010). Vitamin E neuroprotection for cisplatin neuropathy: A randomized, placebo-controlled trial. Neurology. 74(9):762–766.
   PubMed Web of Science ®Google Scholar
• Pan, L., Gao, H., and Xing, X. R. (2012). Combined application of traditional Chinese medicine prevention of taxol chemotherapy-induced peripheral neuropathy; a clinical observation. Neimenggu Zhong Yi Yao. 3:28.
   Google Scholar
• Park, S. B., Krishnan, A. V., Lin, C. S. Y., Goldstein, D., Friedlander, M., and Kiernan, M. C. (2008). Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies. Curr. Med. Chem. 15(29):3081–3094.
   PubMed Web of Science ®Google Scholar
• Park, J. W., Jeon, J. H., Yoon, J. W., Jung, T. Y., Kwon, K. R., Cho, C. K., Lee, Y. W., Sagar, S., Wong, R., and Yoo, H. S. (2011). Effects of sweet be venom pharmacopuncture for chemotherapy-induced peripheral neuropathy. Integr. Cancer Ther. 11(2):166–171.
   PubMed Web of Science ®Google Scholar
• Pirzada, N. A., Ali, I. I., and Dafer, R. M. (2000) Fluorouracil-induced neurotoxicity. Ann. Pharmacother. 34(1):35–38.
   PubMed Web of Science ®Google Scholar
• Rahn, E. J., Makriyannis, A., and Hohmann, A. G. (2007). Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats. Br. J. Pharmacol. 152(5):765–777
   PubMed Web of Science ®Google Scholar
• Rahn, E. J., Zvonok, A. M., Thakur, G. A., Khanolkar, A. D., Makriyannis, A., and Hohmann, A. G. (2008). Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats. J. Pharmacol. Exp. Ther. 327(2):584–591.
   PubMed Web of Science ®Google Scholar
• Schiff, D., Wen, P. Y., and van den Bent, M. J. (2009). Neurological adverse effects caused by cytotoxic and targeted therapies. Nat. Rev. Clin. Oncol. 6(10):596–603.
   PubMed Web of Science ®Google Scholar
• Schloss, J. M., Colosimo, M., Airey, C., Masci, P. P., Linnane, A. W., and Vitetta, L. (2013). Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): A systematic review. Clin. Nutr. 32(6):888–893
   PubMed Web of Science ®Google Scholar
• Schröder, S., Beckmann, K., Franconi, G., Meyer-Hamme, G., Friedemann, T., Greten, H. J., Rostock, M., and Efferth, T. (2013). Can medical herbs stimulate regeneration or neuroprotection and treat neuropathic pain in chemotherapy-induced peripheral neuropathy? Evid. Based Complement. Alternat. Med. 2013:423713.
   Web of Science ®Google Scholar
• Shindo, Y., Tenma, K., Imano, H., Hibino, M., Yoshino, K., Nakamura, M. (2008). Reduction of oxaliplatin-related neurotoxicity by Gosha-jinki-gan. Gan Tto Kagaku Ryoho. 35(5):863–865.
   PubMedGoogle Scholar
• Sima, L., Pan, L. (2009). Influence of Chinese herb on chemotherapy-induced peripheral neuropathy. Ann. Oncol. 20(3):iii45–iii46.
   Google Scholar
• Simpson, D. M., Brown, S., Tobias, J. K., Vanhove, G. F. For the NGX-4010 C107 Study Group. (2013). NGX-4010, a capsaicin 8% dermal patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: Results of a 52-week open-label study. Clin. J. Pain. 30(2):134–142.
   Web of Science ®Google Scholar
• Sindrup, S. H., Madsen, C., Bach, F. W., Gram, L. F., and Jensen, T. S. (2001). St. John's wort has no effect on pain in polyneuropathy. Pain. 91(3):361–365.
   PubMed Web of Science ®Google Scholar
• Smith, E. M., Pang, H., Cirrincione, C., Fleishman, S., Paskett, E. D., Ahles, T., Bressler, L. R., Fadul, C. E., Knox, C., Le-Lindqwister, N., Gilman, P. B., Shapiro, C. L.; Alliance for Clinical Trials in Oncology. (2013). Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 309(13):1359–1367.
   PubMed Web of Science ®Google Scholar
• Sun, Y. Y., Jia, Y. J., Huang, M. N., and Chen, J. (2008). Buyang huanwu decoction in prevention of peripheral neuropathy after chemotherapy: A clinical observation. Guang. J. Chin. Med. 23(7):958–959.
   Google Scholar
• Takenaka, M., Iida, H., Matsumoto, S., Yamaguchi, S., Yoshimura, N., and Miyamoto, M. (2014). Successful treatment by adding duloxetine to pregabalin for peripheral neuropathy induced by paclitaxel. Am. J. Hosp. Palliat. Care. 330(7):734–736.
   Web of Science ®Google Scholar
• Tandan, R., Lewis, G., Badger, G. B., and Fries, T. (1992). Topical capsaicin in painful diabetic neuropathy: Effect on sensory function. Diabet. Care. 15(1):15–18.
   PubMed Web of Science ®Google Scholar
• Tatsumi, T., Kishi, D., and Kogure, T. (2009). The efficacy of ogikeishigomotsuto on chronic cumulative sensory neuropathy induced by oxaliplatin—case report and literature view. J. Tradit. Med. 26(3):136–140.
   Google Scholar
• Ushio, S., Egashira, N., Sada, H., Kawashiri, T., Shirahama, M., Masuguchi, K., and Oishi, R. (2012). Goshajinkigan reduces oxaliplatin-induced peripheral neuropathy without affecting anti-tumour efficacy in rodents. Eur. J. Cancer. 48(9):1407–1413.
   PubMed Web of Science ®Google Scholar
• Visovsky, C., Meyer, R. R., Roller, J., and Poppas, M. (2008). Evaluation and management of peripheral neuropathy in diabetic patients with cancer. Clin. J. Oncol. Nurs. 12(2):243–247.
   PubMed Web of Science ®Google Scholar
• Wang, C. N., Chi, C. W., Lin, Y. L., Chen, C. F., and Shiao, Y. J. (2001). The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. J. Biol. Chem. 276(7):5287–5295
   PubMed Web of Science ®Google Scholar
• Wang, Q. R. (2007). Yi Lin Gai Guo: Correcting the Errors in the Forest of Medicine. Blue Poppy Press, Boulder, Colo, USA.
   Google Scholar
• Wolf, S., Barton, D., Kottschade, L., Grothey, A., and Loprinzi,  . (2008). Chemotherapy-induced Peripheral Neuropathy: prevention and treatment strategies. Eur. J. Cancer. 44(11):1507–1515
   PubMed Web of Science ®Google Scholar
• Xu, F., Xu, S., Wang, L., Chen, C., Zhou, X., Lu, Y., and Zhang, H. (2011). Antinociceptive efficacy of verticinone in murine models of inflammatory pain and paclitaxel induced neuropathic pain. Biol. Pharmaceut. Bull. 34(9):1377–1382.
   PubMed Web of Science ®Google Scholar
• Xu, O., Lu, H., Li, P. Q., Zhang, X., and Lu, Z. (2004). Effect of combination of Ginkgo leaf extract and deferoxamine in preventing and treating ototoxicity of cisplatin. Zhongguo Zhong Xi Yi Jie He Za Zhi. 24(10):915–918.
   PubMedGoogle Scholar
• Yamada, T., Kan, H., Matsumoto, S., Koizumi, M., Sasaki, J., Tani, A., Yokoi, K., and Uchida, E. (2012). Reduction in oxaliplatin-related neurotoxicity by the administration of Keishikajutsubuto (TJ-18) and powdered processed aconite root. Gan To Kagaku Ryoho. 39(11):1687–1691.
   PubMedGoogle Scholar
• Yamamoto, T., Murai, T., Ueda, M., Katsuura, M., Oishi, M., Miwa, Y., Okamoto, Y., Uejima, E., Taguchi, T., Noguchi, S., and Kurokawa, N. (2009). Clinical features of paclitaxel-induced peripheral neuropathy and role of Gosyajinki-gan. Gan To Kagaku Ryoho. 36(1):89–92.
   PubMedGoogle Scholar
• Yoon, J., Jeon, J. H., Lee, Y. W., Cho, C. K., Kwon, K. R., Shin, J. E., Sagar, S., Wong, R., and Yoo, H. S. (2012). Sweet bee venom pharmacopuncture for chemotherapy-induced peripheral neuropathy. J. Acupunct. Meridian. Stud. 5(4):156–165.
   PubMedGoogle Scholar
• Zhou, Y., Ji, H., Lin, B. Q., Jiang, Y., and Li, P. (2006). The effects of five alkaloids from Bulbus Fritillariae on the concentration of cAMP in HEK cells transfected with muscarinic M(2) receptor plasmid. Am. J. Chin. Med. 34(5):901–910.
   PubMed Web of Science ®Google Scholar