Volatile N-nitrosamines in meat products: Potential precursors, influence of processing, and mitigation strategies

References

• Ahn, H. J., Kim, J. H., Jo, C., Lee, C. H. and Byun, M. W. (2002a). Reduction of carcinogenic N-nitrosamines and residual nitrite in model system sausage by irradiation. Food Chem. Toxicol. 67:1370–1373.
   Google Scholar
• Ahn, H. J., Yook, H.-S., Rhee, M. S., Lee, C. H., Choi, Y. J. and Byun, M. W. (2002b). Application of gamma irradiation on breakdwon of hazardous volatile N-nitrosamines. Food Chem. Toxicol. 67:596–599.
   Google Scholar
• Ahn, H.-J., Kim, J.-H., Jo, C., Lee, J.-W., Yook, H.-S. and Byun, M.-W. (2004a). Effects of gamma irradiation on residual nitrite, residual ascorbate, color, and N-nitrosamines of cooked sausage during storage. Food Control 15:197–203.
   Web of Science ®Google Scholar
• Ahn, H.-J., Kim, J.-H., Jo, C., Lee, J.-W., Yook, H.-S., Kim, H.-Y. and Byun, M.-W. (2004b). Combined effects of gamma irradiation and a modified atmospheric packaging on the physicochemical characteristics of sausage. Radiat. Phys. Chem. 71:53–56.
   Web of Science ®Google Scholar
• Ahn, H.-J., Kim, J.-H., Jo, C., Yook, H.-S. and Byun, M.-W. (2003). Radiolytic characteristics of nitrite by gamma irradiation. Food Chem. 82:465–468.
   Web of Science ®Google Scholar
• Archer, M. C., Tannenbaum, S. R., Fan, T. Y. and Weisman, M. (1975). Reaction of nitrite with ascorbate and its relation to nitrosamine formation. J. Nat. Cancer I. 54:1203–1205.
   PubMed Web of Science ®Google Scholar
• Atawodi, S. E., Maduagwu, E. N., Preussmann, R. and Spiegelhalder, B. (1991). Potential of endogenous formation of volatile nitrosamines from Nigerian vegetables and spices. Cancer Lett. 57:219–222.
   PubMed Web of Science ®Google Scholar
• Ayanaba, A. and Alexander, M. (1973). Microbial formation of nitrosamines in vitro. Appl. Microbiol. 25:862–868.
   PubMedGoogle Scholar
• Aymerich, T., Picouet, P. A. and Monfort, J. M. (2008). Decontamination technologies for meat products. Meat Sci. 78:114–129.
   PubMed Web of Science ®Google Scholar
• Baliga, M. S., Jagetia, G. C., Rao, S. K. and Babu, K. (2003). Evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study. Food/Nahrung 47:261–264.
   PubMedGoogle Scholar
• Bartsch, H., Oshima, H. and Pignatelli, B. (1988). Inhibitors of endogenous nitrosation mechanisms and implications in human cancer prevention. Mutat. Res. 202:307–324.
   PubMed Web of Science ®Google Scholar
• Becker, M. E., Westermann, S., Hansson, M. and Skibsted, L. H. (2012). Parallel enzymatic and non-enzymatic formation of zinc protoporphyrin IX in pork. Food Chem. 130:832–840.
   Web of Science ®Google Scholar
• Behsnilian, D., Butz, P., Greiner, R. and Lautenschlaeger, R. (2014). Process-induced undesirable compounds: chances of non-thermal approaches. Meat Sci. 98:392–403.
   PubMed Web of Science ®Google Scholar
• Belitz, H. D., Grosch, W. and Schieberle, P. (2004). Food Chemistry. Springer-Verlag, New York.
   Google Scholar
• Bills, D. D., Hildrum, K. I., Scanlan, R. A. and Libbey, L. M. (1973). Potential precursors of N-nitrosopyrrolidine in Bacon and other fried foods. J. Agric. Food Chem. 21:876–877.
   PubMed Web of Science ®Google Scholar
• Byun, M.-W., Ahn, H.-J., Kim, J.-H., Lee, J.-W., Yook, H.-S. and Han, S.-B. (2004). Determination of volatile N-nitrosamines in irradiated fermented sausage by gas chromatography coupled to a thermal energy analyzer. J. Chromatogr. A 1054:403–407.
   PubMed Web of Science ®Google Scholar
• Cassens, R. G. (1997). Composition and safety of cured meats in the USA. Food Chem. 59:561–566.
   Web of Science ®Google Scholar
• Choi, S. Y., Chung, M. J., Lee, S.-J., Shin, J. H. and Sung, N. J. (2007). N-nitrosamine inhibition by strawberry, garlic, kale, and the effects of nitrite-scavenging and N-nitrosamine formation by functional compounds in strawberry and garlic. Food Control 18:485–491.
   Web of Science ®Google Scholar
• Combet, E., Preston, T. and Mccoll, K. E. (2010). Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. Rapid Commun. Mass Sp. 24:529–534.
   PubMed Web of Science ®Google Scholar
• De Maere, H., De Mey, E., Dewulf, L., Fraeye, I., Chollet, S. and Paelinck, H. (2014). Influence of pH on (zinc)protoporphyrin IX formation in dry fermented sausages assessed using a fast screening method. Proc. 60th ICOMST. Punte Del Este, Uruguay.
   Google Scholar
• De Mey, E., De Klerck, K., De Maere, H., Dewulf, L., Derdelinckx, G., Peeters, M.-C., Fraeye, I., Vander Heyden, Y., Paelinck, H. (2014a). The occurrence of N-nitrosamines, residual nitrite and biogenic amines in commercial dry fermented sausages and evaluation of their occasional relation. Meat Sci. 96:821–828.
   PubMed Web of Science ®Google Scholar
• De Mey, E., De Maere, H., Dewulf, L., Paelinck, H., Sajewicz, M., Fraeye, I. and Kowalska, T. (2014b). Assessment of the N-nitrosopiperidine formation risk from piperine and piperidine contained in spices used as meat product additives. Eur. Food Res. Technol. 238:477–484.
   Web of Science ®Google Scholar
• De Mey, E., De Maere, H., Goemaere, O., Steen, L., Peeters, M.-C., Derdelinckx, G., Paelinck, H. and Fraeye, I. (2014c). Evaluation of N-nitrosopiperidine formation from biogenic amines during the production of dry fermented sausages. Food Bioprocess Technol. 7:1269–1280.
   Web of Science ®Google Scholar
• De Mey, E., Viaene, J., Dejaegher, B., Maere, H., Dewulf, L., Paelinck, H., Vander Heyden, Y. and Fraeye, I. (2014d). A Study of the Effects of pH and Water Activity on the N-Nitrosopiperidine Formation in a Protein-Based Liquid System. Food Bioprocess Technol. 7:2978–2987.
   Web of Science ®Google Scholar
• Demasi, T., Grimes, L. and Dick, R. A. (1989). Nitrosoheme pigment formation and light effects on color properties of semidry, nonfermented and fermented sausages. J. Food Protect. 52:189–193.
   PubMed Web of Science ®Google Scholar
• Devik, O. G. (1967). Formation of N-nitrosamines by the Maillard reaction. Acta Chem. Scandinavica 21:2302–2303.
   PubMedGoogle Scholar
• Diehl, J. F. (2002). Food irradiation-Past, present and future. Radiat. Phys. Chem. 63:211–215.
   Web of Science ®Google Scholar
• Dineen, N., Kerry, L., Lynch, P., Buckley, D., Morrissey, P. and Arendt, E. (2000). Reduced nitrite levels and dietary alpha-tocopheryl acetate supplementation: Effects on the colour and oxidative stability of cooked hams. Meat Sci. 55:475–482.
   PubMed Web of Science ®Google Scholar
• Directive. (2006). Directive 2006/52/EC of the European Parliament and of the Council of 5 July 2006 amending Directive 95/2/EC on food additives other than colours and sweeteners and Directive 95/35/EC on sweeteners for use in foodstuffs. O.J., L204.
   Google Scholar
• Domańska, K. and Kowalski, B. (2002). Effect of different storage conditions on N-nitrosamine content in polish edible offals processed meat products. Bull. Vet. Inst. Pulawy 46:317–324.
   Web of Science ®Google Scholar
• Domanska, K. and Kowalski, B. (2003). Occurrence of volatile N-nitrosamines in polish processed meat products. Bull. Vet. Inst. Pulawy 47:507–514.
   Web of Science ®Google Scholar
• Domańska, K. and Różańska, H. (2003). Microbiological quality of polish edible offals processed meat productsduring storage: influence on N-nitrosamine content. Bull. Vet. Inst. Pulawy 47:217–223.
   Google Scholar
• Domanska-Blicharz, K., Michalski, M. and Kowalski, B. (2004). Effect of different storage conditions on nitrates and nitrites in polish edible offals processed meat products. Influence on N-nitrosamines content. Bull. Vet. Inst. Pulawy 48:63–68.
   Google Scholar
• Drabik-Markiewicz, G., Dejaegher, B., De Mey, E., Impens, S., Kowalska, T., Paelinck, H. and Vander Heyden, Y. (2010). Evaluation of the influence of proline, hydroxyproline or pyrrolidine in the presence of sodium nitrite on N-nitrosamine formation when heating cured meat. Anal. Chim. Acta 657:123–130.
   PubMed Web of Science ®Google Scholar
• Drabik-Markiewicz, G., Dejaegher, B., De Mey, E., Kowalska, T., Paelinck, H. and Vander Heyden, Y. (2011). Influence of putrescine, cadaverine, spermidine or spermine on the formation of N-nitrosamine in heated cured pork meat. Food Chem. 126:1539–1545.
   PubMed Web of Science ®Google Scholar
• Drabik-Markiewicz, G., Van den Maagdenberg, K., De Mey, E., Deprez, S., Kowalska, T. and Paelinck, H. (2009). Role of proline and hydroxyproline in N-nitrosamine formation during heating in cured meat. Meat Sci. 81:479–486.
   PubMed Web of Science ®Google Scholar
• Ender, F. and Čeh, L. (1971). Conditions and chemical reaction mechanisms by which nitrosamines may be formed in biological products with reference to their possible occurrence in food products. Z. Lebensm. Unters. For. 145:133–142.
   Google Scholar
• Eskandari, M. H., Hosseinpour, S., Mesbahi, G. and Shekarforoush, S. (2013). New composite nitrite-free and low-nitrite meat-curing systems using natural colorants. Food Sci. Nutr. 1:392–401.
   PubMedGoogle Scholar
• Fan, T. Y. and Tannenbaum, S. R. (1973). Factors influencing the rate of formation of nitrosomorpholine from morpholine and nitrite. Acceleration by thiocyanate and other anions. J. Agric. Food Chem. 21:237–240.
   PubMed Web of Science ®Google Scholar
• Fernández-López, J., Viuda-Martos, M., Sendra, E., Sayas-Barberá, E., Navarro, C. and Pérez-Alvarez, J. A. (2006). Orange fibre as potential functional ingredient for dry-cured sausages. Eur. Food Res. Technol. 226:1–6.
   Web of Science ®Google Scholar
• Fiddler, W., Gates, R. A., Pensabene, J. W., Philips, J. G. and Wierbicki, E. (1981). Investigations on nitrosamines in irradiation-sterilized bacon. J. Agric. Food Chem. 29:551–554.
   PubMed Web of Science ®Google Scholar
• Fiddler, W., Pensabene, J. W., Piotrowski, E. G., Doerr, R. C. and Wasserman, A. E. (1973). Use of sodium ascorbate or erythorbate to inhibit formation of N‐nitrosodimethylamine in Frankfurters. J. Food Sci. 38:1084–1086.
   Web of Science ®Google Scholar
• Fiddler, W., Pensabene, J., Piotrowski, E., Phillips, J., Keating, J., Mergens, W. and Newmark, H. (1978). Inhibition of formation of volatile nitrosamines in fried bacon by the use of cure-solubilized alpha-tocopherol. J. Agric. Food Chem. 26:653–656.
   PubMed Web of Science ®Google Scholar
• Fridman, A. L., Mukhametshin, F. M. and Novikov, S. S. (1971). Advances in the chemistry of aliphatic N-Nitrosamines. Russian Chem. Rev. 40:34–50.
   Google Scholar
• Gough, T. A. and Goodhead, K. (1975). Occurrence of volatile nitrosamines in spice premixes. J. Sci. Food Agric. 26:1473–1478.
   Web of Science ®Google Scholar
• Gray, J. I. and Collins, M. E. (1977a). A comparison of proline and putrescine as precursors of N-nitrosopyrrolidine in nitrite-treated pork system. J. Food Sci. 42(4):1034–1037.
   Web of Science ®Google Scholar
• Gray, J. I. and Collins, M. E. (1977b). The development of free proline during the storage of green pork bellies. Can. I. Food Sc. Tech. J. 10:97–99.
   Web of Science ®Google Scholar
• Gray, J. I., Collins, M. E. and Russell, L. F. (1977c). Formation of N-nitrosohydroxypyrrolidine in model and cured meat systems. Can. I. Food Sc. Tech. J. 10:36–39.
   Web of Science ®Google Scholar
• Habermeyer, M. and Eisenbrand, G. (2009). N-nitrosamines, including N-nitrosoaminoacids and potential further nonvolatiles. In: Process-induced food toxicants: Occurrence, formation, mitigation, and health risks, 365–386. Stadler, R. H. and Lineback, D. R., Eds. John Wiley, Hoboken.
   Google Scholar
• Havery, D. C., Fazio, T. and Howard, H. W. (1978). Trend in levels of N-nitrosopyrrolidine in fried bacon. J. Assoc. Off. Anal. Chem. 61:1379–1382.
   PubMedGoogle Scholar
• Havre, G. N. and Ender, F. (1971). The formation of methyl substituted pyrazines in the Maillard reaction, and the interference by such compounds in the determination of N-nitrosamines in foodstuffs. Z. Lebensm. Unters. Forsch. 146:74–79.
   Google Scholar
• Herrmann, S. S. (2014). N-nitrosamines in processed meat products- analysis, occurrence, formation, mitigation and exposure. Soborg: Technical University of Denmark.
   Google Scholar
• Herrmann, S. S., Duedahl-Olesen, L. and Granby, K. (2015a). Occurrence of volatile and non-volatile N-nitrosamines in processed meat products and the role of heat treatment. Food Control 48:163–169.
   Web of Science ®Google Scholar
• Herrmann, S. S., Granby, K. and Duedahl-Olesen, L. (2015b). Formation and mitigation of N-nitrosamines in nitrite preserved sausages. Food Chem. 174:516–526.
   PubMed Web of Science ®Google Scholar
• Hildrum, K. I. (1975a). Formation of nitrosamines from the nitrosation of spermine and spermidine. Cornval: Oregon State University.
   Google Scholar
• Hildrum, K., Williams, J. and Scanlan, R. (1975b). Effect of sodium chloride concentration on the nitrosation of proline at different pH levels. J. Agric. Food Chem. 23:439–442.
   PubMed Web of Science ®Google Scholar
• Honikel, K. (2008). The use and control of nitrate and nitrite for the processing of meat products. Meat Sci. 78:68–76.
   PubMed Web of Science ®Google Scholar
• Hotchkiss, J. H. and Parker, R. S. (1990). Toxic compounds produced during cooking and meat processing. In: Meat and health, advances in meat research, pp. 105–134. Pearson, A. M. and Dutson, T. R., Eds., Elsevier Science Pub., Essex.
   Google Scholar
• Huxel, E., Scanlan, R. and Libbey, L. (1974). Formation of nitrosopyrrolidine from pyrrolidine ring containing compounds at elevated temperatures. J. Agric. Food Chem. 22:698–700.
   Web of Science ®Google Scholar
• IARC. (1998). Some N-nitroso compounds. In: IARC Monographs on the evaluation of risks to humans. 17., International Agency for Research on Cancer, Lyon.
   Google Scholar
• Jakszyn, P. and Gonzalez, C.-A. (2006). Nitrosamine and related food intake and gastric and oesophageal cancer risk: a systematic review of the epidemiological evidence. World J. Gastroenterol. 12:4296–4303.
   PubMed Web of Science ®Google Scholar
• Janzowski, C. E. (1978). Occurrence of N-nitrosamino acids in cured meat products and their effect on formation of N-nitrosamines during heating. Food Cosmet. Toxicol. 16:343–348.
   PubMedGoogle Scholar
• Jo, C., Ahn, H., Son, J., Lee, J. and Byun, M. (2003). Packaging and irradiation effect on lipid oxidation, color, residual nitrite content, and nitrosamine formation in cooked pork sausage. Food Control 14:7–12.
   Web of Science ®Google Scholar
• Juncher, D., Rønn, B., Beck Hansen, T., Henckel, P., Karlsson, A. H. S. L. and Bertelsen, G. (2003). Effect of pre-slaughter physiological conditions on the oxidative stability of colour and lipid during chill storage of sliced, retail packed roast ham. Meat Sci. 63:151–159.
   PubMed Web of Science ®Google Scholar
• Jurak, G., Bošnir, J., Puntarić, D., Pavlinić-Prokurica, I., Šmit, Z., Medić, H., Puntarić, I. and Puntarić, E. (2013). Effects of temperature, length of storage, and technological processes on the formation of N-nitrosamines in liver pâté. Acta Aliment. Hung 42:481–494.
   Web of Science ®Google Scholar
• Kataoka, H., Kurisu, M. and Shindoh, S. (1997). Determination of volatile N-nitrosamines in combustion smoke samples. B. Environ. Contam. Tox. 59:570–576.
   PubMed Web of Science ®Google Scholar
• Kato, H., Lee, I. E., Van Chuyen, N., Kim, S. B. and Hayase, F. (1987). Inhibition of nitrosamine formation by nondialyzable melanoidins. Agric. Biol. Chem. 51:1333–1338.
   Web of Science ®Google Scholar
• Kawahara, Y., Nakamura, M., Sakagami, I. and Suzuki, Y. (2006). Technical paper Bright Red Color Formation of Cooked Pork Loin Cured with Lactic Acid Bacteria Starter Culture without Adding Nitrite During Low-Temperature Storage. Food Sci. Technol. 12:101–107.
   Web of Science ®Google Scholar
• Kikugawa, K. and Kato, T. (1991). Prevention of nitrosamine formation. In: Mutagens in Food: Detection and Prevention, 205–214. Hayatsu, H., CRC Press, Boca Raton.
   Google Scholar
• Kim, J. H., Ahn, H. J., Jo, C., Park, H. J., Chung, Y. J. and Byun, M. W. (2004). Radiolysis of biogenic amines in model system by gamma irradiation. Food Control 15:405–408.
   Web of Science ®Google Scholar
• Kim, J.-H., Ahn, H.-J., Lee, J.-W., Park, H.-J., Ryu, G.-H., Kang, I.-J. and Byun, M.-W. (2005). Effects of gamma irradiation on the biogenic amines in pepperoni with different packaging conditions. Food Chem. 89:199–205.
   Web of Science ®Google Scholar
• Kocak, D., Ozel, M. Z., Gogus, F., Hamilton, J. F. and Lewis, A. C. (2012). Determination of volatile nitrosamines in grilled lamb and vegetables using comprehensive gas chromatography - nitrogen chemiluminescence detection. Food Chem. 135:2215–22120.
   PubMed Web of Science ®Google Scholar
• Krul, C., Zeilmaker, M., Schothorst, R. and Havenaar, R. (2004). Intragastric formation and modulation of N-nitrosodimethylamine in a dynamic in vitro gastrointestinal model under human physiological conditions. Food Chem. Toxicol. 42:51–63.
   PubMed Web of Science ®Google Scholar
• Kurechi, T., Kikugawa, K. and Ozawa, M. (1980). Effect of malondialdehyde on nitrosamine formation. Food Cosmet. Toxicol. 18:119–22.
   PubMedGoogle Scholar
• Lee, M. L., Gray, J., Pearson, A. M. and Kakuda, Y. (1983). Formation of N‐Nitrosopyrrolidine in Fried Bacon: Model System Studies. J. Food Sci. 48:820–824.
   Web of Science ®Google Scholar
• Li, L., Shao, J., Zhu, X., Zhou, G. and Xu, X. (2013a). Effect of plant polyphenols and ascorbic acid on lipid oxidation, residual nitrite and N-nitrosamines formation in dry-cured sausage. Int. J. Food Sci. Technol. 48:1157–1116.
   Web of Science ®Google Scholar
• Li, L., Wang, P., Xu, X. and Zhou, G. (2012). Influence of various cooking methods on the concentrations of volatile N-nitrosamines and biogenic amines in dry-cured sausages. J. Food Sci. 77:560–565.
   PubMed Web of Science ®Google Scholar
• Li, P., Kong, B., Chen, Q., Zheng, D. and Liu, N. (2013b). Formation and identification of nitrosylmyoglobin by Staphylococcus xylosus in raw meat batters: a potential solution for nitrite substitution in meat products. Meat Sci. 93:67–72.
   PubMed Web of Science ®Google Scholar
• Lijinsky, W. (1999). N-Nitroso compounds in the diet. Mut. Res. 443:129–138.
   PubMed Web of Science ®Google Scholar
• Lijinsky, W. and Epstein, S. S. (1970). Nitrosamines as environmental carcinogens. Nature 225:21–23.
   PubMed Web of Science ®Google Scholar
• Lin, H. and Sebranek, J. (1979). Effect of sodium nitrite concentration and packaging conditions on color stability and rancidity development in sliced bologna. J. Food Sci. 44:1451–1454.
   Web of Science ®Google Scholar
• Liu, R. H., Conboy, J. J. and Hotchkiss, J. H. (1988). Nitrosation by nitro-nitroso derivatives of olefins: a potential mechanism for N-nitrosamine formation in fried bacon. J. Agr. Food Chem. 36:984–987.
   Web of Science ®Google Scholar
• McCutcheon, J. W. (1984). Nitrosamines in bacon: a case study of balancing risks. Public Health Rep. 99:360–364.
   PubMed Web of Science ®Google Scholar
• Meineri, G., Medana, C., Giancotti, V., Visentin, S. and Peiretti, P. G. (2013). Effect of dietary supplementation of vitamin E in pigs to prevent the formation of carcinogenic substances in meat products. J. Food Compos. Anal. 30:67–72.
   Web of Science ®Google Scholar
• Mirvish, S. S. (1975). Formation of N-Nitroso Compounds: Chemistry, Kinetics, and in Vivo Occurrence. Toxicol. Appl. Pharma. 31:325–351.
   PubMed Web of Science ®Google Scholar
• Mottram, D. S., Patterson, R. L., Rhodes, D. N. and Gough, T. A. (1975). Influence of ascorbic acid and ph on the formation of n‐nitrosodimethylamine in cured pork containing added dimethylamine. J. Sci. Food Agric. 26:47–53.
   PubMed Web of Science ®Google Scholar
• Nakamura, M., Baba, N., Nakaoka, T., Wada, Y., Ishibashi, T. and Kawabata, T. (1976). Pathways of formation of N-nitrosopyrrolidine in fried bacon. J. Food Sci. 41:874–877.
   Web of Science ®Google Scholar
• Nakamura, M., Katoh, K. and Kawabata, T. (1981). Precursors to Nitrosopyrrolidine and nitrosopiperidine in black pepper treated with nitrous acid. Agr. Biol. Chem. Tokyo 45:1257–1259.
   Web of Science ®Google Scholar
• Nikolov, P. Y. and Yaylayan, V. A. (2010). Formation of Pent-4-en-1-amine, the counterpart of acrylamide from lysine and its conversion into piperidine in lysine/glucose reaction mixtures. J. Agric. Food Chem. 58:4456–4462.
   PubMed Web of Science ®Google Scholar
• Ordóñez, J. A., Hierro, E. M., Bruna, J. M. and Hoz, L. D. L. (1999). Changes in the components of dry-fermented sausages during ripening. Crit. Rev Food Sci. Nut. 39:329–367.
   PubMed Web of Science ®Google Scholar
• Osawa, T., Namiki, M. and Namiki, K. (1982). Mutagen formation in the nitrite-piperic acid [obtained from black pepper] reaction. Agric. Biol. Chem. Tokyo 46:3105–3108.
   Web of Science ®Google Scholar
• Özcan, M. M. and Akbulut, M. (2008). Estimation of minerals, nitrate and nitrite contents of medicinal and aromatic plants used as spices, condiments and herbal tea. Food Chem. 106:852–858.
   Web of Science ®Google Scholar
• Ozel, M. Z., Gogus, F., Yagci, S., Hamilton, J. F. and Lewis, A. C. (2010). Determination of volatile nitrosamines in various meat products using comprehensive gas chromatography-nitrogen chemiluminescence detection. Food Chem. Toxicol. 48:3268–3273.
   PubMed Web of Science ®Google Scholar
• Parolari, G., Benedini, R. and Toscani, T. (2009). Color formation in nitrite-free dried hams as related to Zn-protoporphyrin IX and Zn-chelatase activity. J. Food Sci. 74:C413–418.
   PubMed Web of Science ®Google Scholar
• Paul, K. T., Hull, T. R., Lebek, K. and Stec, A. A. (2008). Fire smoke toxicity: The effect of nitrogen oxides. Fire Safety J. 43:243–251.
   Web of Science ®Google Scholar
• Pensabene, J. W., Fiddler, W., Doerr, R. C., Lakritz, L. and Wasserman, A. E. (1975). Formation of dimethylnitrosamine from commercial lecithin and its components in a model system. J. Agric. Food Chem. 23:979–980.
   PubMed Web of Science ®Google Scholar
• Pensabene, J., Fiddler, W., Gates, R., Fagan, J. and Wasserman, A. (1974). Effect of frying and other conditions on nitrosopyrrolidine formation in bacon. J. Food Sci. 39:314–316.
   Web of Science ®Google Scholar
• Pourazrang, H., Moazzami, A. and Bazzaz, B. S. (2002). Inhibition of mutagenic N-nitroso compound formation in sausage samples by using l-ascorbic acid and α-tocopherol. Meat Sci. 62:479–483.
   PubMed Web of Science ®Google Scholar
• Rabie, M. a. and Toliba, A. O. (2013). Effect of irradiation and storage on biogenic amine contents in ripened Egyptian smoked cooked sausage. J. Food Sci. Technol. 50:1165–1171.
   PubMed Web of Science ®Google Scholar
• Rywotycki, R. (2002). The effect of selected functional additives and heat treatment on nitrosamine content in pasteurized pork ham. Meat Sci. 60:335–339.
   PubMed Web of Science ®Google Scholar
• Rywotycki, R. (2003a). Meat nitrosamine contamination level depending on animal breeding factors. Meat Sci. 65:669–676.
   PubMed Web of Science ®Google Scholar
• Rywotycki, R. (2003b). The influence of environment, mode of nutrition and animal species on level of nitrosamine contamination in venison. Meat Sci. 65:1045–1053.
   PubMed Web of Science ®Google Scholar
• Rywotycki, R. (2007). The effect of baking of various kinds of raw meat from different animal species and meat with functional additives on nitrosamine contamination level. Food Chem. 101:540–548.
   Web of Science ®Google Scholar
• Sato, K. and Hegarty, G. R. (1971). Warmed-over flavor in cooked meats. J. Food Sci. 36:1098–1102.
   Web of Science ®Google Scholar
• Schuddeboom, L. J. (1993). Nitrates and nitrites in foodstuffs. Council of Europe Press, Publishing and Documentation Service.
   Google Scholar
• Schulz, H., Baranska, M., Quilitzsch, R., Schütze, W. and Lösing, G. (2005). Characterization of peppercorn, pepper oil, and pepper oleoresin by vibrational spectroscopy methods. J. Agric. Food Chem. 53:3358–3363.
   PubMed Web of Science ®Google Scholar
• Scotter, M. J. and Castle, L. (2004). Chemical interactions between additives in foodstuffs: a review. Food Addit. Contam. 21:93–124.
   PubMed Web of Science ®Google Scholar
• Sebranek, J. G. (1979). Advances in the technology of nitrite use and consideration of alternatives. Food Technol. 33:58–62.
   Web of Science ®Google Scholar
• Sebranek, J. G. and Bacus, J. N. (2007). Cured meat products without direct addition of nitrate or nitrite: what are the issues? Meat Sci. 77:136–147.
   PubMed Web of Science ®Google Scholar
• Sen, N. P. and Baddoo, P. A. (1986). Origin of N‐Nitrosomorpholine Contamination in Margarine. J. Food Sci. 51:216–217.
   Web of Science ®Google Scholar
• Sen, N. P., Baddoo, P. A. and Seaman, S. W. (1993). Nitrosamines in cured pork products packaged in elastic rubber nettings : An update. Food Chem. 47:387–390.
   Web of Science ®Google Scholar
• Sen, N. P., Donaldson, B., Seaman, S., Iyengar, J. R. and Miles, W. F. (1976). Inhibition of nitrosamine formation in fried bacon by propyl gallate and L-ascorbyl palmitate. J. Agr. Food Chem. 24:397–401.
   PubMed Web of Science ®Google Scholar
• Shahidi, F. and Pegg, R. B. (1992). Nitrite-free meat curing systems: Update and review. Food Chem. 43:185–191.
   Web of Science ®Google Scholar
• Silla Santos, M. H. (1996). Biogenic amines: Their importance in foods. Int. J. Food Microbiol. 29:213–231.
   PubMed Web of Science ®Google Scholar
• Sindelar, J. J. (2006). Investigating uncured no-nitrate-or-nitrite added processed meat products. Iowa Stae University, Ames.
   Google Scholar
• Skibsted, L. H. (2011). Nitric Oxide Nitric oxide and quality and safety of muscle based foods. Nitric Oxide 4:176–183.
   Web of Science ®Google Scholar
• Song, B.-S., Choi, S.-J., Jin, Y.-B., Park, J.-H., Kim, J.-K., Byun, E.-B., Kim, J. H., Lee, J. W., Kim, G. S., Marchioni, E. (2014). A critical review on toxicological safety of 2-alkylcyclobutanones. Radiat. Phys. Chem. 103:188–193.
   Web of Science ®Google Scholar
• Sun, W., Meng, P. and Ma, L. (2014). Relationship between N-nitrosodiethylamine formation and protein oxidation in pork protein extracts. Eur. Food Res. Technol. 239:679–686.
   Web of Science ®Google Scholar
• Suzzi, G. and Gardini, F. (2003). Biogenic amines in dry fermented sausages: a review. Int. J. Food Microbiol. 88:41–54.
   PubMed Web of Science ®Google Scholar
• Tanaka, K. H. (1998). Inhibition of N-nitrosation of secondary amines in vitro by tea extracts and catechins. Mutat. Res. 412:91–98.
   PubMed Web of Science ®Google Scholar
• Theiler, R., Sato, K., Aspelund, T. and Miller, A. (1981). Model system studies on N-nitrosamine formation in cured meats: The effect of curing solution ingredients. J. Food Sci. 46:996–998.
   Web of Science ®Google Scholar
• Theiler, R., Sato, K., Aspelund, T. and Miller, A. (1984). Inhibition of N‐Nitrosamine Formation in a Cured Ground Pork Belly Model System. J. Food Sci. 49:341–344.
   Web of Science ®Google Scholar
• Tsai, P.-J., Tsai, T.-H., Yu, C.-H., & Ho, S.-C. (2007). Evaluation of NO-suppressing activity of several Mediterranean culinary spices. Food Chem. Toxicol. 45:440–447.
   PubMed Web of Science ®Google Scholar
• USDA. (2012). Code of Federal Regulation. Title 21 Food and Drugs, part 170 Food Additives. US Food and Drug administration. http://www.accessdata.fda.gov, accessed 20.3.2015.
   Google Scholar
• Viuda-Martos, M., Fernández-López, J., Sayas-Barbera, E., Sendra, E., Navarro, C. and Pérez-Alvarez, J. A. (2009). Citrus co-products as technological strategy to reduce residual nitrite content in meat products. J. Food Sci. 74:93–100.
   PubMed Web of Science ®Google Scholar
• Wakamatsu, J., Nishimura, T. and Hattori, A. (2004). A Zn-porphyrin complex contributes to bright red color in Parma ham. Meat Sci. 67:95–100.
   PubMed Web of Science ®Google Scholar
• Wang, Y., Li, F., Zhuang, H., Chen, X., Li, L., Qiao, W. and Zhang, J. (2015). Effects of plant polyphenols and α-tocopherol on lipid oxidation, residual nitrites, biogenic amines, and N-nitrosamines formation during ripening and storage of dry-cured bacon. LWT-Food Sci. Technol. 60:199–206.
   Web of Science ®Google Scholar
• Warthesen, J. J., Scanlan, R. A., Bills, D. D. and Libbey, L. M. (1975). Formation of heterocyclic N-nitrosamines from the reaction of nitrite and selected primary diamines and amino acids. J. Agric. Food Chem. 23:898–902.
   PubMed Web of Science ®Google Scholar
• Wei, F., Xu, X., Zhou, G., Zhao, G., Li, C., Zhang, Y., Chen, L. and Qi, J. (2009). Irradiated Chinese Rugao ham: Changes in volatile N-nitrosamine, biogenic amine and residual nitrite during ripening and post-ripening. Meat Sci. 81:451–455.
   PubMed Web of Science ®Google Scholar
• Weiss, J., Gibis, M., Schuh, V. and Salminen, H. (2010). Advances in ingredient and processing systems for meat and meat products. Meat Sci. 86:196–213.
   PubMed Web of Science ®Google Scholar
• Williams, R. L., Pace, R. J. and Jeacocke, G. J. (1964). Applications of solvent effects-I The spectra of secondary nitrosamines. Spectrochim. Acta 20:225–236.
   Web of Science ®Google Scholar
• Yang, H., Meng, P., Wang, R., Li, P. R., Li, P. W. and Ma, L. Z. (2012). Effect of oxidized myofibrils protein subjected to multiple freeze-thaw cycles on N-nitrosamine formation in in vitro model system. Adv. Mater. Res. 550:1590–1594.
   Google Scholar
• Yang, H., Meng, P., Xiong, Y. L., Ma, L., Wang, C. and Zhu, Y. (2013). Oxidation in HiOx-packaged pork Longissimus muscle predisposes myofibrillar and sarcoplasmic proteins to N-nitrosamine formation in nitrite-curing solution. Meat Sci. 95:465–471.
   PubMed Web of Science ®Google Scholar
• Yurchenko, S. and Mölder, U. (2007). The occurrence of volatile N-nitrosamines in Estonian meat products. Food Chem. 100:1713–1721.
   Web of Science ®Google Scholar
• Zhang, X., Kong, B. and Xiong, Y. L. (2007). Production of cured meat color in nitrite-free Harbin red sausage by Lactobacillus fermentum fermentation. Meat Sci. 77:593–598.
   PubMed Web of Science ®Google Scholar
• Zhou, J., Bai, R. and Zhu, Y. (2007). Determination of four tobacco-specific nitrosamines in mainstream cigarette smoke by gas chromatography/ion trap mass spectrometry. Rapid Commun. Mass Sp. 21:4086–4092.
   PubMed Web of Science ®Google Scholar
• Zink, D. L. (1997). The impact of consumer demands and trends on food processing. Emerg. Infect. Dis. 3:467–469.
   PubMed Web of Science ®Google Scholar