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Anti-inflammatory effects of phytochemicals from fruits, vegetables, and food legumes: A review

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  • Ali, N. M., Mohd Yusof, H., Yeap, S. K., Ho, W. Y., Beh, B. K., Long, K., Koh, S. P., Abdullah, M. P., and Alitheen, N. B. (2014). Anti-inflammatory and antinociceptive activities of untreated, germinated, and fermented mung bean aqueous extract. Evid. Based Complement Alternat. Med. 2014:1–6.
  • Alencar, N. M., Teixeira, E. H., Assreuy, A. M., Cavada, B. S., Flores, C. A., and Ribeiro, R. A. (1999). Leguminous lectins as tools for studying the role of sugar residues in leukocyte recruitment. Mediators Inflamm. 8:107–113.
  • Alencar, N. M., Assreuy, A. M., Criddle, D. N., Souza, E. P., Soares, P. M., Havt, A., Aragão, K. S., Bezerra, D. P., Ribeiro, R. A., and Cavada, B. S. (2004). Vatairea macrocarpa lectin induces paw edema with leukocyte infiltration. Protein Pept. Lett. 11:195–200.
  • Araújo, T. S., Teixeira, C. S., Falcão, M. A., Junior, V. R., Santiago, M. Q., Benevides, R. G., Delatorre, P., Martins, J. L., Alexandre-Moreira, M. S., Cavada, B. S., Campesatto, E. A., and Rocha, B. A. (2013). Anti-inflammatory and antinociceptive activity of chitin-binding lectin from Canna limbata seeds. Appl. Biochem. Biotechnol. 171:1944–1955.
  • Assreuy, A. M., Shibuya, M. D., Martins, G. J., Souza, M. L., Cavada, B. S., Moreira, R. A., Oliveira, J. T. A., Ribeiro, R. A., and Flores, C. A. (1997). Anti-inflammatory effect of glucose-mannose binding lectins isolated from Brazilian beans. Mediators Inflamm. 6:201–210.
  • Assreuy, A. M., Martins, G. J., Moreira, M. E., Brito, G. A., Cavada, B. S., Ribeiro, R. A., and Flores, C. A. (1999). Prevention of cyclophosphamide-induced hemorrhagic cystitis by glucose-mannose binding plant lectins. J. Urol. 161:1988–1993.
  • Benjamin, C. F., Figueiredo, R. C., Henriques, M. G., and Barja-Fidalgo, C. (1997). Inflammatory and anti-inflammatory effects of soybean agglutinin. Braz. J. Med. Biol. Res. 30:873–881.
  • Bezerra, G. A., Viertlmayr, R., Moura, T. R., Delatorre, P., Rocha, B. A. M., do Nascimento, K. S., Figueiredo, J. G., Bezerra, I. G., Teixeira, C. S., Simoes, R. C., Nagano, C. S., de Alencar, N. M. N., Gruber, K., and Cavada, B. S. (2014). Structural studies of an anti-inflammatory lectin from Canavalia boliviana seeds in complex with dimannosides. PLoS ONE. 9:e97015.
  • Bodet, C., La, V. D., Epifano, F., and Grenier, D. (2008). Naringenin has antiinflammatory properties in macrophage andex vivo human whole-blood models. J. Periodontal Res. 43:400–407.
  • Boudjou, S., Oomah, B. D., Zaidi, F., and Hosseinian, F. (2013). Phenolics content and antioxidant and anti-inflammatory activities of legume fractions. Food Chem. 138:1543–1550.
  • Chen, L., Teng, H., Xie, Z. L., Cao, H., Cheang, W. S., Skalicka, W. K., Georgiey, M. I., and Xiao, J. B. (2016). Modifications of dietary flavonoids towards improved bioactivity: An update on structure-activity relationship. Crit Rev Food Sci. Nutr. DOI: 10.1080/10408398.2016.1196334.
  • Chien, T. Y., Chen, L. G., Lee, C. J., Lee, F. Y., and Wang, C. C. (2008). Anti-inflammatory constituents of Zingiber zerumbet. Food Chem. 110:584–589.
  • Christensen, L. P. (2009). Galactolipids as potential health promoting compounds in vegetable foods. Recent Pat. Food Nutr. Agric. 1:50–58.
  • Comalada, M., Ballester, I., Bailon, E., Sierra, S., Xaus, J., Galvez, J., de Medina, F. S., and Zarzuelo, A. (2006). Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: Analysis of the structure-activity relationship. Biochem. Pharmacol. 72:1010–1021.
  • Das, A., and Parida, S. K. (2014). Advances in biotechnological applications in three important food legumes. Plant Biotechnol. Rep. 8(2):83–99.
  • Devi, K. P., Malar, D. S., Nabavi, S. F., Sureda, A., Xiao, J., and Nabavi, S. M., et al. (2015). Kaempferol and inflammation: from chemistry to medicine. Pharmacol. Res. 99:1–10.
  • Djordjevic, T. M. (2011). Antioxidant activity and total phenolic content in some cereals and legumes. Int. J. Food Prop. 14(1):175–184.
  • Du, B., Lin, C. Y., Bian, Z. X., and Xu, B. J. (2015). An insight into anti-inflammatory effects of fungal beta-glucans. Trends Food Sci. Tech. 41:49–59.
  • Duranti, M. (2006). Grain legume proteins and nutraceutical properties. Fitoterapia. 77:67–82.
  • Etoh, T., Kim, Y. P., Hayashi, M., Suzawa, M., Li, S., Ho, C., and Komiyama, K. (2013). Inhibitory effect of a formulated extract from multiple citrus peels on LPS-induced inflammation in RAW 246.7 macrophages. Func. Food Health Disease. 3:242–253.
  • Fazio, A., Plastina, P., Meijerink, J., Witkamp, R. F., and Gabriele, B. (2013). Comparative analyses of seeds of wild fruits of Rubus and Sambucus species from Southern Italy: Fatty acid composition of the oil, total phenolic content, antioxidant and anti-inflammatory properties of the methanolic extracts. Food Chem. 140:817–824.
  • Frontela-Saseta, C., López-Nicolás, R., González-Bermúdez, C. A., Martínez-Graciá, C., and Ros-Berruezo, G. (2013). Anti-inflammatory properties of fruit juices enriched with pine bark extract in anin vitro model of inflamed human intestinal epithelium: The effect of gastrointestinal digestion. Food Chem. Toxicol. 53:94–99.
  • García-Lafuente, A., Moro, C., Manchón, N., Gonzalo-Ruiz, A., Villares, A., Guillamón, E., Rostagno, M., and Mateo-Vivaracho, L. (2014). In vitro anti-inflammatory activity of phenolic rich extracts from white and red common beans. Food Chem. 161:216–223.
  • García-Lafuente, A., Guillamón, E., Villares, A., Rostagno, M. A., and Martínez, J. A. (2009). Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm. Res. 58(9):537–552.
  • García-Mediavilla, V., Crespo, I., Collado, P. S., Esteller, A., Sánchez-Campos, S., Tuñón, M. J., and González-Gallego, J. (2007). The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappa B pathway in chang liver cells. Eur. J. Pharmacol. 557:221–229.
  • Guang, G., Chen, J., Sang, S. Y., and Cheng, S. Y. (2014). Biological functionality of soyasaponins and soyasapogenols. J. Agric. Food Chem. 62:8247–8255.
  • Ha, S K., Park, H. Y., Eom, H., Kim, Y., and Choi, I. (2012). Narirutin fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-κ;B and MAPKs activation. Food Chem. Toxicol. 50:3498–3504.
  • Hernández-Ledesma, B., Hsieh, C. C., and de Lumen, B. O. (2009). Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages. Biochem. Biophys. Res. Commun. 390:803–808.
  • Hou, C. C., Chen, Y. P., Wu, J. H., Huang, C. C., Wang, S. Y., Yang, N. S., and Shyur, L. F. A (2007). galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma. Cancer Res. 67:6907–6915.
  • Hsu, C., Tsai, T. H., Li, Y. Y., Wu, W. H., Huang, C. J., and Tsai, P. J. (2012). Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation. Food Chem. 135:976–984.
  • Ismail, T., Sestili, P., and Akhtar, S. (2012). Pomegranate peel and fruit extracts: A review of potential anti-inflammatory and anti-infective effects. J. Ethnopharmacol. 143:397–405.
  • Jiang, J., Kang, T. B., Shim, D. W., Oh, N. H., Kim, T. J., and Lee, K. H. (2013). Indole-3-carbinol inhibits LPS-induced inflammatory response by blocking TRIF-dependent signaling pathway in macrophages. Food Chem. Toxicol. 57:256–261.
  • Jiang, Y., Zeng, K. W., David, B., and Massiot, G. (2014). Constituents of Vigna angularis and their in vitro anti-inflammatory activity. Phytochemistry. 107:111–118.
  • Kang, J., Xie, C., Li, Z., Nagarajan, S., Schauss, A. G., Wu, T., and Wu, X. L. (2011). Flavonoids from acai (Euterpe oleracea Mart.) pulp and their antioxidant and antiinflammatory activities. Food Chem. 128:152–157.
  • Kang, J. H., Sung, M. K., Kawada, T., Yoo, H., Kim, Y. K., Kim, J. S., and Yu, R. (2005). Soybean saponins suppress the release of proinflammatory mediators by LPS-stimulated peritoneal macrophages. Cancer Lett. 230:219–227.
  • Kim, H. P., Son, K. H., Chang, H. W., and Kang, S. S. (2004). Anti-inflammatory plant flavonoids and cellular action mechanisms. J. Pharmacol. Sci. 96(3):229–245.
  • Kim, K. M., Kwon, Y. G., Chung, H. T., Yun, Y. G., Pae, H. O., Han, J. A., Ha, K. S., Kim, T. W., and Kim, Y. M. (2003). Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-κ;B activation. Toxicol. Appl. Pharm. 190:1–8.
  • Lau, F. C., Bielinski, D. F., and Joseph, J. A. (2007). Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia. J. Neurosci. Res. 85:1010–1017.
  • Lee, I. A., Park, Y. J., Yeo, H. K., Han, M. J., and Kim, D. H. (2010). Soyasaponin I attenuates TNBS-Induced colitis in mice by inhibiting NF-κ;B pathway. J. Agric. Food Chem. 58:10929–10934.
  • Lee, S. I., Kim, B. S., Kim, K. S., Lee, S., Shin, K. S., and Lim, J. S. (2008). Immune-suppressive activity of punicalagin via inhibition of NFAT activation. Biochem. Biophys. Res. Commun. 371:799–803.
  • Leite, J. F., Assreuy, A. M., Mota, M. R., Bringel, P. H., Lacerda, R. R., Gomes Vde, M., Cajazeiras, J. B., Nascimento, K. S., Pessôa Hde, L., Gadelha, C. A., Delatorre, P., Cavada, B. S., and Santi-Gadelha, T. (2012). Antinociceptive and anti-inflammatory effects of a lectin-like substance from Clitoria fairchildiana R. Howard seeds. Molecules. 17:3277–3290.
  • Li, X., Zhang, J. Y., Gao, W. Y., and Wang, H. Y. (2012). Study on chemical composition, anti-inflammatory and anti-microbial activities of extracts from Chinese pear fruit (Pyrus bretschneideri Rehd.). Food Chem. Toxicol. 50:3673–3679.
  • Li, X., Wang, T., Zhou, B., Gao, W., Cao, J., and Huang, L. (2014). Chemical composition and antioxidant and anti-inflammatory potential of peels and flesh from 10 different pear varieties (Pyrus spp.). Food Chem. 152:531–538.
  • Lin, J. Y., and Tang, C. Y. (2008). Strawberry, loquat, mulberry, and bitter melon juices exhibit prophylactic effects on LPS-induced inflammation using murine peritoneal macrophages. Food Chem. 107:1587–1596.
  • Liu, C. J., and Lin, J. Y. (2013). Anti-inflammatory effects of phenolic extracts from strawberry and mulberry fruits on cytokine secretion profiles using mouse primary splenocytes and peritoneal macrophages. Int. Immunopharmacol. 16:165–170.
  • Luo, J. Q, Cai, W. C., Wu, T., and Xu, B. J. (2016). Phytochemical distribution in hull and cotyledon of adzuki bean and mung bean, and their contribution to antioxidant activities, anti-inflammatory, and anti-diabetic effects. Food Chemistry. 201:350–360.
  • Moise, J. A., Han, S., Gudynaite-Savitch, L., Johnson, D. A., and Miki, B. L. A. (2005). Seed coats: Structure, development, composition, biotechnology. In Vitro Cell Dev Pl. 41:620–644.
  • Mueller, D., Triebel, S., Rudakovski, O., and Richling, E. (2013). Influence of triterpenoids present in apple peel on inflammatory gene expression associated with inflammatory bowel disease (IBD). Food Chem. 139:339–346.
  • Mcinnes, I. B., and Georg, S. (2011). The pathogenesis of rheumatoid arthritis. N. Engl. J. Med. 365(5):2205–2219.
  • Mueller, M., Hobiger, S., and Jungbauer, A. (2010). Anti-inflammatory activity of extracts from fruits, herbs and spices. Food Chem. 122:987–996.
  • Murakami, A., Nakamura, Y., Koshimizu, K., and Ohigashi, H. (1995). Glyceroglycolipids from Citrus hystrix, a traditional herb in Thailand, potently inhibit the tumor-promoting activity of 12-O-tetradecanoylphorbol 13-acetate in mouse skin. J. Agric. Food Chem. 43:2779–2783.
  • Needleman, P., and Isakson, P. C. (1997). The discovery and function of COX-2. J. Rheumatol. 49:6–8.
  • Oliveira, T. M., Delatorre, P., Rocha, B. A. M., Souza, E. P., Nascimento, K. S., Bezerra, G. A., Moura, T. R., Benevides, R. G., Bezerra, E. H. S., Moreno, F. B., Freire, V. N., de Azevedo, W. F. Jr., and Cavada, B. S. (2008). Crystal structure of Dioclea rostrata: Insights into understanding the pH-dependent dimer-tetramer equilibrium and the structural basis for carbohydrate recognition in Diocleinae lectins. J. Struct. Biol. 164:177–182.
  • Oomah, B. D., Corbe, A., and Balasubramanian, P. (2010). Antioxidant and anti-inflammatory activities of bean (Phaseolus vulgaris L.) hulls. J. Agric. Food Chem. 58:8225–8230.
  • Ouachrif, A., Khalki, H., Chaib, S., Mountassir, M., Aboufatima, R., Farouk, L., Benharraf, A., and Chait, A. (2012). Comparative study of the anti-inflammatory and antinociceptiv eeffects of two varieties of Punica granatum. Pharma. Biol. 50:429–438.
  • Park, H. J., Kim, S. J., Park, S. J., Eom, S. H., Gu, G. J., Kim, S. H., and Youn, H. S. (2013). Phenethyl isothiocyanate regulates inflammation through suppression of the TRIF-dependent signaling pathway of Toll-like receptors. Life Sci. 92:793–798.
  • Park, S., Choi, K. C., Fang, M., Lim, Y. C., Jeon, Y. M., and Lee, J. C. (2011). Red bean extract reduces inflmmation and increases survival murine sepsis model. Food Sci. Biotechnol. 20:1125–1131.
  • Patto, M. C. V., Amarowicz, R., Aryee, A. N. A., Boye, J. I., and Chung, H. J. (2014). Achievements and challenges in improving the nutritional quality of food legumes. Crit. Rev. Plant Sci. 34(1):105–143.
  • Pereira, A., and Maraschin, M. (2015). Banana (Musa spp) from peel to pulp: Ethnopharmacology, source of bioactive compounds and its relevance for human health. J. Ethnopharmacol. 160:149–163.
  • Pitura, K. (2011). Evaluation of the antioxidant activity of extracts and flavonol glycosides isolated from the seed coats of colored beans (Phaseolus vulgaris L.). The University of Manitoba. Master Dissertation.
  • Rathee, P., Chaudhary, H., Rathee, S., Rathee, D., Kumar, V., and Kohli, K. (2009). Mechanism of action of flavonoids as anti-inflammatory agents: A review. Inflamm Allergy - Drug Targets. 8(3):229–235(7).
  • Rice-Evans, C. A., and Miller, N. J. (1996). Antioxidant activities of flavonoids as bioactive components of food. Biochem. Soc. Trans. 24:790–794.
  • Romier, B., Van De Walle, J., During, A., Larondelle, Y., and Schneider, Y. J. (2008). Modulation of signalling nuclear factor-kappaB activation pathway by polyphenols in human intestinal Caco-2 cells. Br. J. Nutr. 100:542–551.
  • Sohn, D. W., Bae, W. J., Kim, H. S., Kim, S. W., and Kim, S. W. (2014). The anti-inflammatory and antifibrosis effects of anthocyanin extracted from black soybean on a Peyronie disease rat model. Urology. 84:1112–1116.
  • Sreerama, Y. N., Takahashi, Y., and Yamaki, K. (2012). Phenolic antioxidants in some vigna species of legumes and their distinct inhibitory effects on α-glucosidase and pancreatic lipase activities. J Food Sci. 77(9):C927–C933.
  • Terra, X., Valls, J., Vitrac, X., Mérrillon, J. M., Arola, L., Ardèvol, A., Bladé, C., Fernandez-Larrea, J., Pujadas, G., Salvadó, J., and Blay, M. (2007). Grape-seed procyanidins act as antiinflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signaling pathway. J. Agric. Food Chem. 55:4357–4365.
  • Vernaza, M. G., Dia, V. P., Mejia, E. G., and Chang, Y. K. (2012). Antioxidant and antiinflammatory properties of germinated and hydrolysed Brazilian soybean flours. Food Chem. 134:2217–2225.
  • Wang, B. S., Huang, G. J., Lu, Y. H., and Chang, L. W. (2013). Anti-inflammatory effects of an aqueous extract of Welsh onion green leaves in mice. Food Chem. 138:751–756.
  • Xiao, J. B. (2017). Dietary flavonoid aglycones and their glycosides: What show better biological benefits? Crit Rev Food Sci. Nutr. 57:1874–1905.
  • Xiao, J. B., Capanoglu, E., Jassbi, A. R., Miron, A. (2016). Advance on the flavonoid C-glycosides and health benefits. Crit. Rev Food Sci. Nutr. 56(S1):S29–S45.
  • Xu, B. J., and Chang, S. K. C. (2009). Total phenolic, phenolic acid, anthocyanin, flavan-3-ol, and flavonol profiles and antioxidant properties of pinto and black beans (Phaseolus vulgaris L.) as affected by thermal processing. J. Agric. Food Chem. 57:4754–4764.
  • Xu, B. J., and Chang, S. S. K. (2011). Reduction of antiproliferation capacities, cell-based- antioxidant capacities and phytochemical contents of common beans and soybeans upon thermal processing. Food Chemistry. 129:974–981.
  • Yamaguchi, K. K. L., Pereira, L. F. R., Lamarão, C. V., Lima, E. S., and da Veiga-Junior, V. F. (2015). Amazon acai: Chemistry and biological activities: A review. Food Chem. 179:137–151.
  • Yu, T., Ahn, H. M., Shen, T., Yoon, K., Jang, H. J., Lee, Y. J., Yang, H. M., Kim, J. H., Kim, C., Han, M. H., Cha, S. H., Kim, T. W., Kim, S. Y., Lee, J., and Cho, J. Y. (2011). Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans. J. Ethnopharmacol. 137:1197–1206.
  • Zha, L. Y., Mao, L. M., Lu, X. C., Deng, H., Ye, J. F., Chu, X. W., Sun, S. X., and Luo, H. J. (2011). Anti-inflammatory effect of soyasaponins through suppressing nitric oxide production in LPS-stimulated RAW 264.7 cells by attenuation of NF-κ;B-mediated nitric oxide synthase expression. Bioorg. Med. Chem. Lett. 21:2415–2418.
  • Zhang, X. W., Shang, P. P., Qin, F., Zhou, Q., Gao, B. Y., Huang, H. Q., Yang, H. S., Shi, H. M., and Yu, L. L. (2013). Chemical composition and antioxidative and anti-inflammatory properties of ten commercial mung bean samples. LWT - Food Sci.Technol. 54:171–178.
  • Zhang, C., Monk, J. M., Lu, J. T., Zarepoor, L., Wu, W., Liu, R., Pauls, K. P., Wood, G. A., Robinson, L., Tsao, R., and Power, K. A. (2014). Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis. Br. J. Nutr. 111:1549–1563.
  • Zhu, Q., Liao, C. L., Liu, Y. M., Wang, P. C., Guo, W., He, M. J., and Huang, Z. B. (2012a). Ethanolic extract and water-soluble polysaccharide from Chaenomeles speciosa fruit modulate lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. J. Ethnopharmacol. 144:441–447.
  • Zhu, S., Li, W., Li, J. H., Jundoria, A., Sama, A. E., and Wang, H. (2012b). It is not just folklore: The aqueous extract of mung bean coat is protective against sepsis. Evid. Based Complement Alternat. Med. 2012:1–10.
  • Zia-Ul-Haq, M., Landa, P., Kutil, Z., Qayum, M., and Ahmad, S. (2013). Evaluation of anti-inflammatory activity of selected legumes from Pakistan: In vitro inhibition of Cyclooxygenase-2. Pak. J. Pharm. Sci. 26:185–187.

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