Cucurmin, anticancer, & antitumor perspectives: A comprehensive review

References

• Abe, Y., Hashimoto, S. H. U. and Horie, T. (1999). Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol. Res. 39:41–47.
   PubMed Web of Science ®Google Scholar
• Adams, B. K., Cai, J., Armstrong, J., Herold, M., Lu, Y. J., Sun, A., Snyder, J. P., Liotta, D. C., Jones, D. P. and Shoji, M. (2005). EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anti-Cancer Drugs. 16:263–275.
   PubMed Web of Science ®Google Scholar
• Aggarwal, B. B., Banerjee, S., Bharadwaj, U., Sung, B., Shishodia, S. and Sethi, G. (2007). Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines. Biochem. Pharmacol. 73:1024–1032.
   PubMed Web of Science ®Google Scholar
• Aggarwal, B. B., Kumar, A. and Bharti, A. C. (2003). Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res. 23:363–398.
   PubMed Web of Science ®Google Scholar
• Aggarwal, B. B., Sethi, G., Ahn, K. S., Sandur, S. K., Pandey, M. K., Kunnumakkara, A. B., Sung, B. and Ichikawa, H. (2006). Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer. Ann. New York Acad. Sci. 1091:151–169.
   PubMed Web of Science ®Google Scholar
• Aggarwal, S., Takada, Y., Singh, S., Myers, J. N. and Aggarwal, B. B. (2004). Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling. Int. J. Cancer. 111:679–692.
   PubMed Web of Science ®Google Scholar
• Akkoç, Y., Berrak, Ö., Arısan, E. D., Obakan, P., Çoker-Gürkan, A. and Palavan-Ünsal, N. (2015). Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells. Biomed. Pharmacother. 71:161–171.
   PubMed Web of Science ®Google Scholar
• Al-Hujaily, E. M., Mohamed, A. G., Al-Sharif, I., Youssef, K. M., Manogaran, P. S., Al-Otaibi, B., Al-Haza'a, A., Al-Jammaz, I., Al-Hussein, K. and Aboussekhra, A. (2010). PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells. Breast Cancer Res. Treat. 128:97–107.
   PubMed Web of Science ®Google Scholar
• Amin, A. R. M. R., Haque, A., Rahman, M. A., Chen, Z. G., Khuri, F. R. and Shin, D. M. (2015). Curcumin induces apoptosis of upper aerodigestive tract cancer cells by targeting multiple pathways. PloS One. 10:e0124218.
   PubMed Web of Science ®Google Scholar
• Anto, R. J. (2002). Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: Its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis. 23:143–150.
   PubMed Web of Science ®Google Scholar
• Aoki, H., Takada, Y., Kondo, S., Sawaya, R., Aggarwal, B. B. and Kondo, Y. (2007). Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: Role of akt and extracellular signal-regulated kinase signaling pathways. Mol. Pharmacol. 72:29–39.
   PubMed Web of Science ®Google Scholar
• Baum, L., Lam, C. W. K., Cheung, S. K.-K., Kwok, T., Lui, V., Tsoh, J., Lam, L., Leung, V., Hui, E., Ng, C., Woo, J., Chiu, H. F. K., Goggins, W. B., Zee, B. C.-Y., Cheng, K. F., Fong, C. Y. S., Wong, A., Mok, H., Chow, M. S. S., Ho, P. C., Ip, S. P., Ho, C. S., Yu, X. W., Lai, C. Y. L., Chan, M.-H., Szeto, S., Chan, I. H. S. and Mok, V. (2008). Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer Disease. J. Clin. Psychopharmacol. 28:110–113.
   PubMed Web of Science ®Google Scholar
• Beattie, T. L., Zhou, W., Robinson, M. O. and Harrington, L. (1998). Reconstitution of human telomerase activity in vitro. Curr. Biol. 8:177–180.
   PubMed Web of Science ®Google Scholar
• Bimonte, S., Barbieri, A., Palma, G., Luciano, A., Rea, D. and Arra, C. (2013). Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer. BioMed. Res. Int. 2013, Article ID 810423, 8 pages. https://doi.org/10.1155/2013/810423.
   Web of Science ®Google Scholar
• Bisht, S., Feldmann, G., Soni, S., Ravi, R., Karikar, C., Maitra, A. and Maitra, A. (2007). Polymeric nanoparticle-encapsulated curcumin (“nanocurcumin”): A novel strategy for human cancer therapy. J. Nanobiotechnology. 5:3.
   PubMedGoogle Scholar
• Bisht, S., Mizuma, M., Feldmann, G., Ottenhof, N. A., Hong, S.-M., Pramanik, D., Chenna, V., Karikari, C., Sharma, R. and Goggins, M. G. (2010). Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol. Cancer Ther. 9:2255–2264.
   PubMed Web of Science ®Google Scholar
• Bowman, T., Garcia, R., Turkson, J. and Jove, R. (2000). STATs in oncogenesis. Oncogene. 19:2474–2488.
   PubMed Web of Science ®Google Scholar
• Bromberg, J. (2000). Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development. Breast Cancer Res. 2:86.
   PubMed Web of Science ®Google Scholar
• Burger, R. A., Sill, M. W., Monk, B. J., Greer, B. E. and Sorosky, J. I. (2007). Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A gynecologic oncology group study. J. Clin. Oncol. 25:5165–5171.
   PubMed Web of Science ®Google Scholar
• Buys, C. H. C. M. (2000). Telomeres, telomerase, and cancer. New England J. Med. 342:1282–1283.
   PubMed Web of Science ®Google Scholar
• Calaf, G. (2012). Effect of curcumin on irradiated and estrogen-transformed human breast cell lines. Int. J. Oncol. 40:436–442.
   PubMed Web of Science ®Google Scholar
• Calaf, G. M., Echiburu-Chau, C., Ror, D., Chai, Y., Wen, G. and Balajee, A. S. (2011). Protective role of curcumin in oxidative stress of breast cells. Oncol. Rep. 26:1029–1035.
   PubMed Web of Science ®Google Scholar
• Cao, A. L., Tang, Q. F., Zhou, W. C., Qiu, Y. Y., Hu, S. J. and Yin, P. H. (2014). Ras/ERK signaling pathway is involved in curcumin-induced cell cycle arrest and apoptosis in human gastric carcinoma AGS cells. J. Asian Nat. Prod. Res. 17:56–63.
   PubMed Web of Science ®Google Scholar
• Castedo, M., Perfettini, J.-L., Roumier, T., Andreau, K., Medema, R. and Kroemer, G. (2004). Cell death by mitotic catastrophe: A molecular definition. Oncogene. 23:2825–2837.
   PubMed Web of Science ®Google Scholar
• Chadalapaka, G., Jutooru, I., Chintharlapalli, S., Papineni, S., Smith, R., Li, X. and Safe, S. (2008). Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res. 68:5345–5354.
   PubMed Web of Science ®Google Scholar
• Chakravarti, N., Kadara, H., Yoon, D.-J., Shay, J. W., Myers, J. N., Lotan, D., Sonenberg, N. and Lotan, R. (2010). Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer Prev. Res. 3:331–338.
   PubMed Web of Science ®Google Scholar
• Chakravarti, N., Myers, J. N. and Aggarwal, B. B. (2006). Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane). Int. J. Cancer. 119:1268–1275.
   PubMed Web of Science ®Google Scholar
• Chan, M. M.-Y., Huang, H.-I., Fenton, M. R. and Fong, D. (1998). In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem. Pharmacol. 55:1955–1962.
   PubMed Web of Science ®Google Scholar
• Chang, K.-W., Hung, P.-S., Lin, I. Y., Hou, C.-P., Chen, L.-K., Tsai, Y.-M. and Lin, S.-C. (2010). Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPα during oral cancer suppression. Int. J. Cancer. 127:9–20.
   PubMed Web of Science ®Google Scholar
• Charpentier, M. S., Whipple, R. A., Vitolo, M. I., Boggs, A. E., Slovic, J., Thompson, K. N., Bhandary, L. and Martin, S. S. (2013). Curcumin targets breast cancer stem-like cells with microtentacles that persist in mammospheres and promote reattachment. Cancer Res. 74:1250–1260.
   PubMed Web of Science ®Google Scholar
• Chauhan, D. (2002). Chemotherapeutic potential of curcumin for colorectal cancer. CPD. 8:1695–1706.
   Web of Science ®Google Scholar
• Chearwae, W., Anuchapreeda, S., Nandigama, K., Ambudkar, S. V. and Limtrakul, P. (2004). Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder. Biochem. Pharmacol. 68:2043–2052.
   PubMed Web of Science ®Google Scholar
• Chen, B., Zhang, Y., Wang, Y., Rao, J., Jiang, X. and Xu, Z. (2014). Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression. J. Steroid Biochem. Mol. Biol. 143:11–18.
   PubMed Web of Science ®Google Scholar
• Cheng, A.-L., Hsu, C.-H., Lin, J.-K., Hsu, M.-M., Ho, Y.-F., Shen, T.-S., Ko, J.-Y., Lin, J.-T., Lin, B.-R. and Ming-Shiang, W. (2001). Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 21:2895–2900.
   PubMed Web of Science ®Google Scholar
• Chiablaem, K., Lirdprapamongkol, K., Keeratichamroen, S., Surarit, R. and Svasti, J. (2014). Curcumin suppresses vasculogenic mimicry capacity of hepatocellular carcinoma cells through STAT3 and PI3K/AKT inhibition. Anticancer Res. 34:1857–1864.
   PubMed Web of Science ®Google Scholar
• Chisholm, K., Bray, B. J. and Rosengren, R. J. (2004). Tamoxifen and epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells. Anti-Cancer Drugs. 15:889–897.
   PubMed Web of Science ®Google Scholar
• Choudhuri, T., Pal, S., Agwarwal, M. L., Das, T. and Sa, G. (2002). Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett. 512:334–340.
   PubMed Web of Science ®Google Scholar
• Chuang, S.-E., Cheng, A.-L., Lin, J.-K. and Kuo, M.-L. (2000). Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. Food Chem. Toxicol. 38:991–995.
   PubMed Web of Science ®Google Scholar
• Chung, S. S. and Vadgama, J. V. (2015). Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3–NFκB signaling. Anticancer Res. 35:39–46.
   PubMed Web of Science ®Google Scholar
• Clark, L. C. (1996). Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. JAMA. 276:1957.
   PubMed Web of Science ®Google Scholar
• Clark, L. C., Combs, G. F., Turnbull, B. W., Slate, E. H., Chalker, D. K., Chow, J., Davis, L. S., Glover, R. A., Graham, G. F. and Gross, E. G. (1996). Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: A randomized controlled trial. JAMA. 276:1957–1963.
   PubMed Web of Science ®Google Scholar
• Cohen, A. N., Veena, M. S., Srivatsan, E. S. and Wang, M. B. (2009). Suppression of interleukin 6 and 8 production in head and neck cancer cells with curcumin via inhibition of Iκβ kinase. Arch. Otolaryngol. Head Neck Surg. 135:190.
   PubMedGoogle Scholar
• Da, W., Zhu, J., Wang, L. and Sun, Q. (2015). Curcumin suppresses lymphatic vessel density in an in vivo human gastric cancer model. Tumor Biol. 36:5215–5223.
   PubMed Web of Science ®Google Scholar
• Dang, Y.-P., Yuan, X.-Y., Tian, R., Li, D.-G. and Liu, W. (2015). Curcumin improves the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cells via the NF-Κb-p53-caspase-3 pathway. Exp. Ther. Med. 9:1470–1476.
   PubMed Web of Science ®Google Scholar
• Das, K. C. and Das, C. K. (2002). Curcumin (diferuloylmethane), a singlet oxygen quencher. Biochem. Biophys. Res. Commun. 295:62–66.
   PubMed Web of Science ®Google Scholar
• de Paiva Gonçalves, V., Ortega, A. A. C., Guimarães, M. R., Curylofo, F. A., Junior, C. R., Ribeiro, D. A. and Spolidorio, L. C. (2015). Chemopreventive activity of systemically administered curcumin on oral cancer in the 4-nitroquinoline 1‐oxide model. J. Cell. Biochem. 116:787–796.
   PubMed Web of Science ®Google Scholar
• Degterev, A. and Yuan, J. (2008). Expansion and evolution of cell death programmes. Nature Rev. Mol. Cell Biol. 9:378–390.
   PubMed Web of Science ®Google Scholar
• Deng, G., Yu, J., Ye, Z. and Hu, Z. (2008). Curcumin inhibits the expression of vascular endothelial growth factor and androgen-independent prostate cancer cell line PC-3 in vitro. Zhonghua Nan Ke Xue. 14:116–121.
   PubMedGoogle Scholar
• Devi, Y. S., DeVine, M., DeKuiper, J., Ferguson, S. and Fazleabas, A. T. (2015). Inhibition of IL-6 signaling pathway by curcumin in uterine decidual cells. PloS One. 10:e0125627.
   PubMed Web of Science ®Google Scholar
• Dhule, S. S., Penfornis, P., He, J., Harris, M. R., Terry, T., John, V. and Pochampally, R. (2014). The combined effect of encapsulating curcumin and C6 ceramide in liposomal nanoparticles against osteosarcoma. Mol. Pharmaceut. 11:417–427.
   PubMed Web of Science ®Google Scholar
• Divya, C. S. and Pillai, M. R. (2006). Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis. Mol. Carcinog. 45:320–332.
   PubMed Web of Science ®Google Scholar
• Dorai, T., Cao, Y. C., Dorai, B., Buttyan, R. and Katz, A. E. (2001). Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. The Prostate. 47:293–303.
   PubMed Web of Science ®Google Scholar
• Dorai, T., Diouri, J., O'Shea, O. and Doty, S. B. (2014). Curcumin inhibits prostate cancer bone metastasis by up-regulating bone morphogenic protein-7 in vivo. J. Cancer Ther. 05:369–386.
   Google Scholar
• Duan, W., Chang, Y., Li, R., Xu, Q., Lei, J., Yin, C., Li, T., Wu, Y., Ma, Q. and Li, X. (2014). Curcumin inhibits hypoxia inducible�factor-1α-induced epithelial-mesenchymal transition in HepG2 hepatocellular carcinoma cells. Mol. Med. Rep. 10:2505–2510.
   PubMed Web of Science ®Google Scholar
• Duarte, V. M., Han, E., Veena, M. S., Salvado, A., Suh, J. D., Liang, L. J., Faull, K. F., Srivatsan, E. S. and Wang, M. B. (2010). Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of IKK protein of the NF B pathway. Mol. Cancer Ther. 9:2665–2675.
   PubMed Web of Science ®Google Scholar
• Duvoix, A., Blasius, R., Delhalle, S., Schnekenburger, M., Morceau, F., Henry, E., Dicato, M. and Diederich, M. (2005). Chemopreventive and therapeutic effects of curcumin. Cancer Lett. 223:181–190.
   PubMed Web of Science ®Google Scholar
• Ejaz, A., Wu, D., Kwan, P. and Meydani, M. (2009). Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J. Nutrition. 139:919–925.
   PubMed Web of Science ®Google Scholar
• ElAttar, T. M. A. and Virji, A. S. (1999). Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. Anti-Cancer Drugs. 10:187–194.
   PubMed Web of Science ®Google Scholar
• Eom, D.-W., Lee, J. H., Kim, Y.-J., Hwang, G. S., Kim, S.-N., Kwak, J. H., Cheon, G. J., Kim, K. H., Jang, H.-J., Ham, J., Kang, K. S. and Yamabe, N. (2015). Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells. BMB Rep. 48:461–466.
   PubMed Web of Science ®Google Scholar
• Esmatabadi, M. D., Farhangi, B., Safari, Z., Kazerooni, H., Shirzad, H., Zolghadr, F. and Sadeghizadeh, M. (2015). Dendrosomal curcumin inhibits metastatic potential of human SW480 colon cancer cells through down-regulation of claudin1, zeb1 and hef1-1 gene expression. Asian Pac. J. Cancer Prev. 16:2473–2481.
   PubMedGoogle Scholar
• Faião-Flores, F., Quincoces Suarez, J. A., Fruet, A. C., Maria-Engler, S. S., Pardi, P. C. and Maria, D. A. (2015). Curcumin analog DM-1 in monotherapy or combinatory treatment with dacarbazine as a strategy to inhibit in vivo melanoma progression. PloS One. 10:e0118702.
   PubMed Web of Science ®Google Scholar
• Fan, Z., Duan, X., Cai, H., Wang, L., Li, M., Qu, J., Li, W., Wang, Y. and Wang, J. (2015). Curcumin inhibits the invasion of lung cancer cells by modulating the PKCα/Nox-2/ROS/ATF-2/MMP-9 signaling pathway. Oncol. Rep. 34:691–698.
   PubMed Web of Science ®Google Scholar
• Farhangi, B., Alizadeh, A. M., Khodayari, H., Khodayari, S., Dehghan, M. J., Khori, V., Heidarzadeh, A., Khaniki, M., Sadeghiezadeh, M. and Najafi, F. (2015). Protective effects of dendrosomal curcumin on an animal metastatic breast tumor. Eur. J. Pharmacol. 758:188–196.
   PubMed Web of Science ®Google Scholar
• Fiala, M. (2015). Curcumin and omega-3 fatty acids enhance NK cell-induced apoptosis of pancreatic cancer cells but curcumin inhibits interferon-γ production: Benefits of omega-3 with curcumin against cancer. Molecules. 20:3020–3026.
   PubMed Web of Science ®Google Scholar
• Fossey, S. L., Bear, M. D., Lin, J., Li, C., Schwartz, E. B., Li, P.-K., Fuchs, J. R., Fenger, J., Kisseberth, W. C. and London, C. A. (2011). The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. BMC Cancer. 11:112.
   PubMed Web of Science ®Google Scholar
• Friedman, L., Lin, L., Ball, S., Bekaii-Saab, T., Fuchs, J., Li, P.-K., Li, C. and Lin, J. (2009). Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells. Anti-Cancer Drugs. 20:444–449.
   PubMed Web of Science ®Google Scholar
• Fujimoto, K. and Takahashi, M. (1997). Telomerase activity in human leukemic cell lines is inhibited by antisense pentadecadeoxynucleotides targeted against c-myc mRNA. Biochem. Biophys. Res. Commun. 241:775–781.
   PubMed Web of Science ®Google Scholar
• Gandhi, P., Khan, Z. and Chakraverty, N. (2011). Soluble curcumin: A promising oral supplement for health management. J. Appl. Pharmaceut. Sci. 1:1–7.
   Google Scholar
• Gerson, S. J. (1990). Oral cancer. Crit. Rev. Oral Biol. Med. 1:153–166.
   PubMedGoogle Scholar
• Gescher, A., Pastorino, U., Plummer, S. M. and Manson, M. M. (1998). Suppression of tumour development by substances derived from the diet-mechanisms and clinical implications. Br. J. Clin. Pharmacol. 45:1–12.
   PubMed Web of Science ®Google Scholar
• Glienke, W., Maute, L., Wicht, J. and Bergmann, L. (2009). Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression. Cancer Invest. 28:166–171.
   Web of Science ®Google Scholar
• Goel, A., Kunnumakkara, A. B. and Aggarwal, B. B. (2008). Curcumin as “Curecumin”: From kitchen to clinic. Biochem. Pharmacol. 75:787–809.
   PubMed Web of Science ®Google Scholar
• Gomez-Bougie, P., Halliez, M., Maïga, S., Godon, C., Kervoëlen, C., Pellat-Deceunynck, C., Moreau, P. and Amiot, M. (2014). Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups. Cancer Biol. Therapy. 16:60–65.
   Web of Science ®Google Scholar
• Gonzales, A. M. and Orlando, R. A. (2008). Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutr. Metab. 5:17.
   Google Scholar
• Guo, F. and Xu, C. J. (2005). Progress on the study of mechanism of the direct action of TCM bioactive components on ovarian cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi. Chinese J. Integrated Traditional Western Med. 25:1140–1144.
   PubMedGoogle Scholar
• Guo, L. D., Shen, Y. Q., Zhao, X. H., Guo, L. J., Yu, Z. J., Wang, D., Liu, L. M. and Liu, J. Z. (2015). Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis. Phytother. Res. 29:357–365.
   PubMed Web of Science ®Google Scholar
• Gupta, S. C., Patchva, S., Koh, W. and Aggarwal, B. B. (2012). Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin. Exp. Pharmacol. Physiol. 39:283–299.
   PubMed Web of Science ®Google Scholar
• Halder, R. C., Almasi, A., Sagong, B., Leung, J., Jewett, A. and Fiala, M. (2015). Curcuminoids and ω-3 fatty acids with anti-oxidants potentiate cytotoxicity of natural killer cells against pancreatic ductal adenocarcinoma cells and inhibit interferon γ production. Front. Physiol. 6.
   PubMed Web of Science ®Google Scholar
• Herr, H. W. and Morales, A. (2008). History of bacillus calmette-guerin and bladder cancer: An immunotherapy success story. J. Urol. 179:53–56.
   PubMed Web of Science ®Google Scholar
• Hirose, Y. and Ohnishi, M. (1997). Chemoprevention by naturally occurring and synthetic agents in oral, liver, and large bowel carcinogenesis. J. Cell. Biochem. Suppl. 27:35–41.
   PubMedGoogle Scholar
• Hodgson, R. M., Wiessler, M. and Kleihues, P. (1980). Preferential methylation of target organ DNA by the oesophageal carcinogen N-nitrosomethylbenzylamine. Carcinogenesis. 1:861–866.
   PubMed Web of Science ®Google Scholar
• Holmäng, S. (2000). Follow-up of patients with noninvasive and superficially invasive bladder cancer. Semin. Urol. Oncol. 18:273–279.
   PubMedGoogle Scholar
• Holy, J. M. (2002). Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cells. Mutat. Res./Genetic Toxicol. Environ. Mutagenesis. 518:71–84.
   PubMed Web of Science ®Google Scholar
• Homesley, H. D., Filiaci, V., Markman, M., Bitterman, P., Eaton, L., Kilgore, L. C., Monk, B. J. and Ueland, F. R. (2007). Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: A gynecologic oncology group study. J. Clin. Oncol. 25:526–531.
   PubMed Web of Science ®Google Scholar
• Hong, R.-L., Spohn, W. H. and Hung, M.-C. (1999). Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu. Clin. Cancer Res. 5:1884–1891.
   PubMed Web of Science ®Google Scholar
• Hsu, C.-H. and Cheng, A.-L. Clinical studies with curcumin. In: Advances in Experimental Medicine and Biology, pp. 471–480. Springer Science, London.
   Google Scholar
• Huang, M.-T., Robertson, F. M., Lysz, T., Ferraro, T., Wang, Z. Y., Georgiadis, C. A., Laskin, J. D. and Conney, A. H. (1992). Inhibitory effects of curcumin on carcinogenesis in mouse epidermis. In: ACS Symposium Series, pp. 338–349. American Chemical Society (ACS).
   Google Scholar
• Inano, H. and Onoda, M. (2002). Prevention of radiation-induced mammary tumors. Int. J. Radiat. Oncol. Biol. Phys. 52:212–223.
   PubMed Web of Science ®Google Scholar
• Iqbal, M., Sharma, S. D., Okazaki, Y., Fujisawa, M. and Okada, S. (2003). Dietary Supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: Possible role in protection against chemical carcinogenesis and toxicity. Pharmacol. Toxicol. 92:33–38.
   PubMedGoogle Scholar
• Ireson, C., Orr, S., Jones, D. J., Verschoyle, R., Lim, C.-K., Luo, J.-L., Howells, L., Plummer, S., Jukes, R. and Williams, M. (2001). Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res. 61:1058–1064.
   PubMed Web of Science ®Google Scholar
• Ireson, C. R., Jones, D. J., Orr, S., Coughtrie, M. W., Boocock, D. J., Williams, M. L., Farmer, P. B., Steward, W. P. and Gescher, A. J. (2002). Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol. Biomarkers Prev. 11:105–111.
   PubMed Web of Science ®Google Scholar
• Ito, M., Niho, S., Nihei, K., Yoh, K., Ohmatsu, H. and Ohe, Y. (2012). Risk factors associated with fatal pulmonary hemorrhage in locally advanced non-small cell lung cancer treated with chemoradiotherapy. BMC Cancer. 12:27.
   PubMed Web of Science ®Google Scholar
• Jain, A., Samykutty, A., Jackson, C., Browning, D., Bollag, W. B., Thangaraju, M., Takahashi, S. and Singh, S. R. (2015). Curcumin inhibits PhIP induced cytotoxicity in breast epithelial cells through multiple molecular targets. Cancer Lett. 365:122–131.
   PubMed Web of Science ®Google Scholar
• Jana, N. R. (2004). Inhibition of proteasomal function by curcumin induces apoptosis through mitochondrial pathway. J. Biol. Chem. 279:11680–11685.
   PubMed Web of Science ®Google Scholar
• Jaruga, E., Salvioli, S., Dobrucki, J., Chrul, S., Bandorowicz-Pikuła, J., Sikora, E., Franceschi, C., Cossarizza, A. and Bartosz, G. (1998a). Apoptosis-like, reversible changes in plasma membrane asymmetry and permeability, and transient modifications in mitochondrial membrane potential induced by curcumin in rat thymocytes. FEBS Lett. 433:287–293.
   PubMed Web of Science ®Google Scholar
• Jaruga, E., Sokal, A., Chrul, S. and Bartosz, G. (1998b). Apoptosis-independent alterations in membrane dynamics induced by curcumin. Exp. Cell Res. 245:303–312.
   PubMed Web of Science ®Google Scholar
• Jee, S.-H., Shen, S.-C., Kuo, M.-L., Tseng, C.-R. and Chiu, H.-C. (1998). Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells. J. Inves. Dermatol. 111:656–661.
   PubMed Web of Science ®Google Scholar
• Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J. and Thun, M. J. (2007). Cancer statistics, 2007. CA: A Cancer J. Clin. 57:43–66.
   PubMed Web of Science ®Google Scholar
• Jemal, A., Thomas, A., Murray, T. and Thun, M. (2002). Cancer statistics, 2002. CA: A Cancer J. Clin. 52:23–47.
   PubMed Web of Science ®Google Scholar
• Jiang, A.-J., Jiang, G., Li, L.-T. and Zheng, J.-N. (2014). Curcumin induces apoptosis through mitochondrial pathway and caspases activation in human melanoma cells. Mol. Biol. Rep. 42:267–275.
   PubMed Web of Science ®Google Scholar
• Jiao, H., Berrada, K., Yang, W., Tabrizi, M., Platanias, L. C. and Yi, T. (1996). Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol. Cell. Biol. 16:6985–6992.
   PubMed Web of Science ®Google Scholar
• Jin, S., Xu, H.-G., Shen, J.-N., Chen, X.-W., Wang, H. and Zhou, J.-G. (2009). Apoptotic effects of curcumin on human osteosarcoma U2OS cells. Orthop. Surg. 1:144–152.
   PubMedGoogle Scholar
• Jobin, C., Bradham, C. A., Russo, M. P., Juma, B., Narula, A. S., Brenner, D. A. and Sartor, R. B. (1999). Curcumin blocks cytokine-mediated NF-κB activation and proinflammatory gene expression by inhibiting inhibitory factor I-κB kinase activity. J. Immunol. 163:3474–3483.
   PubMed Web of Science ®Google Scholar
• John, A. and Tuszynski, G. (2001). The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol. Oncol. Res. 7:14–23.
   PubMedGoogle Scholar
• Kamat, A. M., Tharakan, S. T., Sung, B. and Aggarwal, B. B. (2009a). Curcumin potentiates the antitumor effects of bacillus calmette-guerin against bladder cancer through the downregulation of NF- B and upregulation of TRAIL receptors. Cancer Res. 69:8958–8966.
   PubMed Web of Science ®Google Scholar
• Kamat, A. M., Tharakan, S. T., Sung, B. and Aggarwal, B. B. (2009b). Curcumin potentiates the antitumor effects of bacillus calmette-guerin against bladder cancer through the downregulation of NF-κB and upregulation of TRAIL receptors. Cancer Res. 69:8958–8966.
   PubMed Web of Science ®Google Scholar
• Kang, N., Wang, M.-M., Wang, Y.-H., Zhang, Z.-N., Cao, H.-R., Lv, Y.-H., Yang, Y., Fan, P.-H., Qiu, F. and Gao, X.-M. (2014). Tetrahydrocurcumin induces G2/M cell cycle arrest and apoptosis involving p38 MAPK activation in human breast cancer cells. Food Chem. Toxicol. 67:193–200.
   PubMed Web of Science ®Google Scholar
• Karin, M. and Ben-Neriah, Y. (2000). Phosphorylation meets ubiquitination: The control of NF-κB activity. Annu. Rev. Immunol. 18:621–663.
   PubMed Web of Science ®Google Scholar
• Karunagaran, D., Rashmi, R. and Kumar, T. (2005). Induction of apoptosis by curcumin and its implications for cancer therapy. Curr. Cancer Drug Targets. 5:117–129.
   PubMed Web of Science ®Google Scholar
• Kawamori, T., Lubet, R., Steele, V. E., Kelloff, G. J., Kaskey, R. B., Rao, C. V. and Reddy, B. S. (1999). Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res. 59:597–601.
   PubMed Web of Science ®Google Scholar
• Kelloff, G. J. (1999). Perspectives on cancer chemoprevention research and drug development. In: Advances in Cancer Research, pp. 199–334. Academic Press, Cambridge, Massachusetts, United States.
   Google Scholar
• Kesharwani, P., Banerjee, S., Padhye, S., Sarkar, F. H. and Iyer, A. K. (2015). Parenterally administrable nano-micelles of 3, 4-difluorobenzylidene curcumin for treating pancreatic cancer. Colloids Surf. B: Biointerfaces. 132:138–145.
   PubMed Web of Science ®Google Scholar
• Khafif, A., Lev-Ari, S., Vexler, A., Barnea, I., Starr, A., Karaush, V., Haif, S. and Ben-Yosef, R. (2009). Curcumin: A potential radio-enhancer in head and neck cancer. Laryngoscope. 119:2019–2026.
   PubMed Web of Science ®Google Scholar
• Khan, M., Akhtar, N., Sharma, V. and Pathak, K. (2015). Product development studies on sonocrystallized curcumin for the treatment of gastric cancer. Pharmaceutics. 7:43–63.
   PubMed Web of Science ®Google Scholar
• Kim, B., Kim, H. S., Jung, E.-J., Lee, J. Y., K. Tsang, B., Lim, J. M. and Song, Y. S. (2015). Curcumin induces ER stress-mediated apoptosis through selective generation of reactive oxygen species in cervical cancer cells. Mol. Carcinog. 55:918–928.
   PubMed Web of Science ®Google Scholar
• Kim, H., Park, J., Tak, K.-H., Bu, S. Y. and Kim, E. (2014). Chemopreventive effects of curcumin on chemically induced mouse skin carcinogenesis in BK5.insulin-like growth factor-1 transgenic mice. In Vitro Cell. Dev. Biol. Anim. 50:883–892.
   PubMed Web of Science ®Google Scholar
• Kim, S. G., Veena, M. S., Basak, S. K., Han, E., Tajima, T., Gjertson, D. W., Starr, J., Eidelman, O., Pollard, H. B. and Srivastava, M. (2011a). Curcumin treatment suppresses IKKβ kinase activity of salivary cells of patients with head and neck cancer: A pilot study. Clin. Cancer Res. 17:5953–5961.
   PubMed Web of Science ®Google Scholar
• Kim, S. G., Veena, M. S., Basak, S. K., Han, E., Tajima, T., Gjertson, D. W., Starr, J., Eidelman, O., Pollard, H. B., Srivastava, M., Srivatsan, E. S. and Wang, M. B. (2011b). Curcumin treatment suppresses IKK kinase activity of salivary cells of patients with head and neck cancer: A pilot study. Clin. Cancer Res. 17:5953–5961.
   PubMed Web of Science ®Google Scholar
• Kim, S.-R., Park, H.-J., Bae, Y.-H., Ahn, S.-C., Wee, H.-J., Yun, I., Jang, H.-O., Bae, M.-K. and Bae, S.-K. (2012). Curcumin down-regulates visfatin expression and inhibits breast cancer cell invasion. Endocrinology. 153:554–563.
   PubMed Web of Science ®Google Scholar
• Ko, Y.-C., Lien, J.-C., Liu, H.-C., Hsu, S.-C., Ji, B.-C., Yang, M.-D., Hsu, W.-H. and Chung, J.-G. (2015). Demethoxycurcumin induces the apoptosis of human lung cancer NCI-H460 cells through the mitochondrial-dependent pathway. Oncol. Rep. 2429–2437.
   PubMed Web of Science ®Google Scholar
• Kondo, A., Mogi, M., Koshihara, Y. and Togari, A. (2001). Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells. Biochem. Pharmacol. 61:319–326.
   PubMed Web of Science ®Google Scholar
• Kondo, A., Takeda, T., Li, B., Tsuiji, K., Kitamura, M., Wong, T. F. and Yaegashi, N. (2013). Epigallocatechin-3-gallate potentiates curcumin's ability to suppress uterine leiomyosarcoma cell growth and induce apoptosis. Int. J. Clin. Oncol. 18:380–388.
   PubMed Web of Science ®Google Scholar
• Korutla, L. and Kumar, R. (1994). Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim. Biophys. Acta (BBA) - Mol. Cell Res. 1224:597–600.
   PubMed Web of Science ®Google Scholar
• Kronski, E., Fiori, M. E., Barbieri, O., Astigiano, S., Mirisola, V., Killian, P. H., Bruno, A., Pagani, A., Rovera, F., Pfeffer, U., Sommerhoff, C. P., Noonan, D. M., Nerlich, A. G., Fontana, L. and Bachmeier, B. E. (2014). miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2. Mol. Oncol. 8:581–595.
   PubMed Web of Science ®Google Scholar
• Kumar, A., Dhawan, S., Hardegen, N. J. and Aggarwal, B. B. (1998). Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-κB activation. Biochem. Pharmacol. 55:775–783.
   PubMed Web of Science ®Google Scholar
• Kunnumakkara, A. B., Guha, S., Krishnan, S., Diagaradjane, P., Gelovani, J. and Aggarwal, B. B. (2007). Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor- B-Regulated gene products. Cancer Res. 67:3853–3861.
   PubMed Web of Science ®Google Scholar
• Kunnumakkara, A. B., Sung, B., Ravindran, J., Diagaradjane, P., Deorukhkar, A., Dey, S., Koca, C., Yadav, V. R., Tong, Z. and Gelovani, J. G. (2010). γ-Tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer Res. 70:8695–8705.
   PubMed Web of Science ®Google Scholar
• Kwak, H. J. (2006). Transforming growth factor- 1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells. Mol. Cancer Res. 4:209–220.
   PubMed Web of Science ®Google Scholar
• Labbozzetta, M., Notarbartolo, M., Poma, P., Maurici, A., Inguglia, L., Marchetti, P., Rizzi, M., Baruchello, R., Simoni, D. and D'Alessandro, N. (2009). Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer. Annal. New York Acad. Sci. 1155:278–283.
   PubMed Web of Science ®Google Scholar
• Le, X., Shi, Q., Wang, B., Xiong, Q., Qian, C., Peng, Z., Li, X.-C., Tang, H., Abbruzzese, J. L. and Xie, K. (2000). Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma. J. Interferon Cytokine Res. 20:935–946.
   PubMed Web of Science ®Google Scholar
• Lee, A. Y. L., Fan, C. C., Chen, Y. A., Cheng, C. W., Sung, Y. J., Hsu, C. P. and Kao, T. Y. (2015). Curcumin inhibits invasiveness and epithelial-mesenchymal transition in oral squamous cell carcinoma through reducing matrix metalloproteinase 2, 9 and modulating p53-E-cadherin pathway. Integr. Cancer Ther. 14:484–490.
   PubMed Web of Science ®Google Scholar
• Lee, D. S., Lee, M. K. and Kim, J. H. (2009). Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. Anticancer Res. 29:5039–5044.
   PubMed Web of Science ®Google Scholar
• Leite, K. R., Chade, D. C., Sanudo, A., Sakiyama, B. Y., Batocchio, G. and Srougi, M. (2009). Effects of curcumin in an orthotopic murine bladder tumor model. Int. Braz J. Urol. 35:599–607.
   PubMed Web of Science ®Google Scholar
• Lestari, M. L. A. D. and Indrayanto, G. (2014). Profiles of Drug Substances, Excipients and Related Methodology, pp. 113–204. Academic Press, Cambridge, Massachusetts, United States.
   Google Scholar
• Lev-Ari, S., Starr, A., Katzburg, S., Berkovich, L., Rimmon, A., Ben-Yosef, R., Vexler, A., Ron, I. and Earon, G. (2014). Curcumin induces apoptosis and inhibits growth of orthotopic human non-small cell lung cancer xenografts. J. Nutr. Biochem. 25:843–850.
   PubMed Web of Science ®Google Scholar
• Levy, D. E. and Darnell, J. E. (2002). Signalling: STATs: Transcriptional control and biological impact. Nature Rev. Mol. Cell Biol. 3:651–662.
   PubMed Web of Science ®Google Scholar
• Lewinska, A., Adamczyk, J., Pajak, J., Stoklosa, S., Kubis, B., Pastuszek, P., Slota, E. and Wnuk, M. (2014). Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells. Mutat. Res./Genetic Toxicol. Environ. Mutagen. 771:43–52.
   PubMed Web of Science ®Google Scholar
• Li-duan, Z., Qiang-song, T. and Cui-huan, W. (2006). Growth inhibition and apoptosis inducing mechanisms of curcumin on human ovarian cancer cell line A2780. Chin. J. Integr. Med. 12:126–131.
   PubMedGoogle Scholar
• Li, L., Braiteh, F. S. and Kurzrock, R. (2005). Liposome-encapsulated curcumin. Cancer. 104:1322–1331.
   PubMed Web of Science ®Google Scholar
• Li, S., Yuan, W., Deng, G., Wang, P., Yang, P. and Aggarwal, B. (2011a). Chemical composition and product quality control of turmeric (Curcuma longa L.). Faculty Publications. Paper 1. http://scholarworks.sfasu.edu/agriculture_facultypubs/1.
   Google Scholar
• Li, X., Xie, W., Xie, C., Huang, C., Zhu, J., Liang, Z., Deng, F., Zhu, M., Zhu, W., Wu, R., Wu, J., Geng, S. and Zhong, C. (2014). Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation. Phytother. Res. 28:1553–1560.
   PubMed Web of Science ®Google Scholar
• Li, Y., Zhang, T., Schwartz, S. J. and Sun, D. (2011b). Sulforaphane potentiates the efficacy of 17-Allylamino 17-Demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function. Nutr. Cancer. 63:1151–1159.
   PubMed Web of Science ®Google Scholar
• Liang, T., Zhang, X., Xue, W., Zhao, S., Zhang, X. and Pei, J. (2014). Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway. IJMS. 15:15754–15765.
   Web of Science ®Google Scholar
• Liduan, Z., Qiangsong, T. and Cuihuan, W. (2004). Growth-inhibitory effects of curcumin on ovary cancer cells and its mechanisms. J. Huazhong Univ. Sci. Technolog. Med. Sci. 24:55–58.
   PubMedGoogle Scholar
• Lim, G. P., Yang, F., Chu, T., Chen, P.-P., Beech, W. K., Ubeda, O. and Frautschy, S. A. (2000). Ibuprofen reduces inflammation and plaque pathology in a mouse model for Alzheimer's disease. Neurobiol. Aging. 21:17.
   Google Scholar
• Limtrakul, P., Chearwae, W., Shukla, S., Phisalphong, C. and Ambudkar, S. V. (2006). Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. Mol. Cell. Biochem. 296:85–95.
   PubMed Web of Science ®Google Scholar
• Lin, J.-K. and Lin-Shiau, S.-Y. (2001). Mechanisms of cancer chemoprevention by curcumin. Proc. Natl. Sci. Counc. Repub. China B. 25:59–66.
   PubMedGoogle Scholar
• Lin, L., Hutzen, B., Ball, S., Foust, E., Sobo, M., Deangelis, S., Pandit, B., Friedman, L., Li, C., Li, P.-K., Fuchs, J. and Lin, J. (2009). New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells. Cancer Sci. 100:1719–1727.
   PubMed Web of Science ®Google Scholar
• Lin, Y. G., Kunnumakkara, A. B., Nair, A., Merritt, W. M., Han, L. Y., Armaiz-Pena, G. N., Kamat, A. A., Spannuth, W. A., Gershenson, D. M., Lutgendorf, S. K., Aggarwal, B. B. and Sood, A. K. (2007). Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor- B pathway. Clin. Cancer Res. 13:3423–3430.
   PubMed Web of Science ®Google Scholar
• Liu, C., Chen, Z., Hu, X., Wang, L., Li, C., Xue, J., Zhang, P., Chen, W. and Jiang, A. (2015). MicroRNA-185 downregulates androgen receptor expression in the LNCaP prostate carcinoma cell line. Mol. Med. Rep. 11:4625–4632.
   PubMed Web of Science ®Google Scholar
• Liu, H.-S., Ke, C.-S., Cheng, H.-C., Huang, C.-Y. F. and Su, C.-L. (2011). Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A. Mol. Pharmacol. 80:638–646.
   PubMed Web of Science ®Google Scholar
• LoTempio, M. M. (2005). Curcumin suppresses growth of head and neck squamous cell carcinoma. Clin. Cancer Res. 11:6994–7002.
   PubMed Web of Science ®Google Scholar
• Lu, Y.-P., Cheng, L. R., Huang, M.-T. and H. Conney, A. (1993). Inhibitory effect of curcumin on 12- O -tetradecanoylphorbol-13-acetate-induced increase in ornithine decarboxylase mRNA in mouse epidermis. Carcinogenesis. 14:293–297.
   PubMed Web of Science ®Google Scholar
• Ma, J., Fang, B., Zeng, F., Pang, H., Zhang, J., Shi, Y., Wu, X., Cheng, L., Ma, C., Xia, J. and Wang, Z. (2014). Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells. Toxicol. Lett. 231:82–91.
   PubMed Web of Science ®Google Scholar
• Magalska, A., Sliwinska, M., Szczepanowska, J., Salvioli, S., Franceschi, C. and Sikora, E. (2006). Resistance to apoptosis of HCW-2 cells can be overcome by curcumin- or vincristine-induced mitotic catastrophe. Int. J. Cancer. 119:1811–1818.
   PubMed Web of Science ®Google Scholar
• Mahmoud, N. N. (2000). Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Carcinogenesis. 21:921–927.
   PubMed Web of Science ®Google Scholar
• Majid, S., Dar, A. A., Saini, S., Hirata, H., Shahryari, V., Tanaka, Y., Yamamura, S., Ueno, K., Zaman, M. S., Singh, K., Chang, I., Deng, G., Carroll, P. R. and Dahiya, R. (2011). MicroRNA-205 interdiction of Src-mediated oncogenic pathways in renal cancer. Cancer Res. 71:2936–2936.
   Web of Science ®Google Scholar
• Manjunatha, H. and Srinivasan, K. (2006). Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats. FEBS J. 273:4528–4537.
   PubMed Web of Science ®Google Scholar
• Marczylo, T. H., Verschoyle, R. D., Cooke, D. N., Morazzoni, P., Steward, W. P. and Gescher, A. J. (2006). Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother. Pharmacol. 60:171–177.
   PubMed Web of Science ®Google Scholar
• Marquardt, J. U., Gomez-Quiroz, L., Arreguin Camacho, L. O., Pinna, F., Lee, Y.-H., Kitade, M., Domínguez, M. P., Castven, D., Breuhahn, K., Conner, E. A., Galle, P. R., Andersen, J. B., Factor, V. M. and Thorgeirsson, S. S. (2015). Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer. J. Hepatology. 63:661–669.
   PubMed Web of Science ®Google Scholar
• Masuelli, L., Di Stefano, E., Fantini, M., Mattera, R., Benvenuto, M., Marzocchella, L., Sacchetti, P., Focaccetti, C., Bernardini, R., Tresoldi, I., Izzi, V., Mattei, M., Frajese, G. V., Lista, F., Modesti, A. and Bei, R. (2014). Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas. Oncotarget. 5:10745–10762.
   PubMed Web of Science ®Google Scholar
• Maute, L., Wicht, J. and Bergmann, L. (2009). Wilms' tumour gene 1 (WT1) as a target in curcumin treatment of pancreatic cancer cells. Eur. J. Cancer. 45:874–880.
   PubMed Web of Science ®Google Scholar
• Mehta, H. J., Patel, V. and Sadikot, R. T. (2014). Curcumin and lung cancer-a review. Targeted Oncol. 9:295–310.
   PubMed Web of Science ®Google Scholar
• Mezzanotte, L., An, N., Mol, I. M., Löwik, C. W. G. M. and Kaijzel, E. L. (2014). A new multicolor bioluminescence imaging platform to investigate NF-κB activity and apoptosis in human breast cancer cells. PloS One. 9:e85550.
   PubMed Web of Science ®Google Scholar
• Mishra, S., Tripathi, R., Srivastava, S., Dwivedi, S., Trivedi, P., Dhankher, O. and Khare, A. (2009). Thiol metabolism play significant role during cadmium detoxification by Ceratophyllum demersum L. Bioresour. Technol. 100:2155–2161.
   PubMed Web of Science ®Google Scholar
• Mohan Yallapu, M., Ray Dobberpuhl, M., Michele Maher, D., Jaggi, M. and Chand Chauhan, S. (2012). Design of curcumin loaded cellulose nanoparticles for prostate cancer. CDM. 13:120–128.
   Google Scholar
• Mohankumar, K., Pajaniradje, S., Sridharan, S., Singh, V. K., Ronsard, L., Banerjea, A. C., Benson, C. S., Coumar, M. S. and Rajagopalan, R. (2014). Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin – an in vitro and in silico approach. Chem. Biol. Interact. 210:51–63.
   PubMed Web of Science ®Google Scholar
• Morales, A., Eidinger, D. and Bruce, A. W. (2002). Intracavitary bacillus calmette-guerin in the treatment of superficial bladder tumors. J. Urology. 167:891–894.
   PubMed Web of Science ®Google Scholar
• Morin, D., Barthélémy, S., Zini, R., Labidalle, S. and Tillement, J.-P. (2001). Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation. FEBS Lett. 495:131–136.
   PubMed Web of Science ®Google Scholar
• Motilva, V., Martin, M. J., Luque, M. I. and Alarcön de la Lastra, C. (1996). Role of polymorphonuclear leukocytes and oxygen-derived free radicals in chronic gastric lesion induced by acetic acid in rat. Gen. Pharmacol. 27:545–550.
   PubMedGoogle Scholar
• Mukhopadhyay, A., Banerjee, S., Stafford, L. J., Xia, C., Liu, M. and Aggarwal, B. B. (2002). Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene. 21:8852–8861.
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay, A., Bueso-Ramos, C., Chatterjee, D., Pantazis, P. and Aggarwal, B. B. (2001). Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene. 20:7597–7609.
   PubMed Web of Science ®Google Scholar
• Nagaraju, G. P., Zhu, S., Ko, J. E., Ashritha, N., Kandimalla, R., Snyder, J. P., Shoji, M. and El-Rayes, B. F. (2015). Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer. Cancer Lett. 357:557–565.
   PubMed Web of Science ®Google Scholar
• Nakagawa-Goto, K., Yamada, K., Nakamura, S., Chen, T.-H., Chiang, P.-C., Bastow, K. F., Wang, S.-C., Spohn, B., Hung, M.-C., Lee, F.-Y., Lee, F.-C. and Lee, K.-H. (2007). Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant-taxoid conjugates as novel cytotoxic agents. Bioorg. Med. Chem. Lett. 17:5204–5209.
   PubMed Web of Science ®Google Scholar
• Nakamura, K., Yasunaga, Y., Segawa, T., Ko, D., Moul, J., Srivastava, S. and Rhim, J. (2002). Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. Int. J. Oncol. 21:825–830.
   PubMed Web of Science ®Google Scholar
• Nirmala, C. and Puvanakrishnan, R. (1996). Protective role of curcumin against isoproterenol induced myocardial infarction in rats. Mol. Cell. Biochem. 159:85–93.
   PubMed Web of Science ®Google Scholar
• Norris, I., Sriganth, P. and Premalatha, B. (1999). Dietary curcumin with cisplatin administration modulates tumour marker indices in experimental fibrosarcoma. Pharmacol. Res. 39:175–179.
   PubMed Web of Science ®Google Scholar
• Ogata, Y., Osaki, T., Naka, T., Iwahori, K., Furukawa, M., Nagatomo, I., Kijima, T., Kumagai, T., Yoshida, M., Tachibana, I. and Kawase, I. (2006). Overexpression of PIAS3 suppresses cell growth, restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt Inactivation. Neoplasia. 8:817–825.
   PubMed Web of Science ®Google Scholar
• Ohta, Y., Kobayashi, T. and Ishiguro, I. (1999). Role of endogenous serotonin and histamine in the pathogenesis of gastric mucosal lesions in unanaesthetised rats with a single treatment of compound 48/80, a mast cell degranulator. Pharmacol. Res. 39:261–267.
   PubMed Web of Science ®Google Scholar
• Onoda, M. and Inano, H. (2000). Effect of curcumin on the production of nitric oxide by cultured rat mammary gland. Nitric Oxide. 4:505–515.
   PubMed Web of Science ®Google Scholar
• Pahl, H. L. (1999). Activators and target genes of Rel/NF-κB transcription factors. Oncogene. 18:6853–6866.
   PubMed Web of Science ®Google Scholar
• Papież, M. A. (2012). The influence of curcumin and (−)-epicatechin on the genotoxicity and myelosuppression induced by etoposide in bone marrow cells of male rats. Drug Chem. Toxicol. 36:93–101.
   PubMed Web of Science ®Google Scholar
• Parkin, D. M., Bray, F., Ferlay, J. and Pisani, P. (2005). Global cancer statistics, 2002. CA: A Cancer J. Clin. 55:74–108.
   PubMed Web of Science ®Google Scholar
• Pendurthi, U. R., Williams, J. T. and Rao, L. V. M. (1997). Inhibition of Tissue factor gene activation in cultured endothelial cells by curcumin : suppression of activation of transcription factors Egr-1, AP-1, and NF- B. Arterioscler. Thromb. Vasc. Biol. 17:3406–3413.
   PubMed Web of Science ®Google Scholar
• Periyasamy, S. and Sánchez, E. R. (2002). Antagonism of glucocorticoid receptor transactivity and cell growth inhibition by transforming growth factor-β through AP-1-mediated transcriptional repression. Int. J. Biochem. Cell Biol. 34:1571–1585.
   PubMed Web of Science ®Google Scholar
• Phillips, J. M., Clark, C., Herman-Ferdinandez, L., Moore-Medlin, T., Rong, X., Gill, J. R., Clifford, J. L., Abreo, F. and Nathan, C. A. O. (2011). Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo. Otolaryngol. Head Neck Surg. 145:58–63.
   PubMed Web of Science ®Google Scholar
• Piguet, P. (1989a). Is“ tumor necrosis factor” the major effector of pulmonary fibrosis? Eur. Cytokine Netw. 1:257–258.
   Google Scholar
• Piguet, P. F. (1989b). Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J. Exp. Med. 170:655–663.
   PubMed Web of Science ®Google Scholar
• Piwocka, K., Zabłocki, K., Więckowski, M. R., Skierski, J., Feiga, I., Szopa, J., Drela, N., Wojtczak, L. and Sikora, E. (1999). A novel apoptosis-like pathway, independent of mitochondria and caspases, induced by curcumin in human lymphoblastoid T (Jurkat) cells. Exp. Cell Res. 249:299–307.
   PubMed Web of Science ®Google Scholar
• Radhakrishnan, V. M., Kojs, P., Young, G., Ramalingam, R., Jagadish, B., Mash, E. A., Martinez, J. D., Ghishan, F. K. and Kiela, P. R. (2014). pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: Involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1). PloS One. 9:e85796.
   PubMed Web of Science ®Google Scholar
• Rafatullah, S., Tariq, M., Al-Yahya, M. A., Mossa, J. S. and Ageel, A. M. (1990). Evaluation of turmeric (Curcuma longa) for gastric and duodenal antiulcer activity in rats. J. Ethnopharmacol. 29:25–34.
   PubMed Web of Science ®Google Scholar
• Rajasingh, J., Raikwar, H. P., Muthian, G., Johnson, C. and Bright, J. J. (2006). Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK–STAT pathway in T cell leukemia. Biochem. Biophys. Res. Commun. 340:359–368.
   PubMed Web of Science ®Google Scholar
• Ramachandran, C. and You, W. (1999). Differential sensitivity of human mammary epithelial and breast carcinoma cell lines to curcumin. Breast Cancer Res. Treatment. 54:269–278.
   PubMed Web of Science ®Google Scholar
• Ramamoorthi, G. and Sivalingam, N. (2014). Molecular mechanism of TGF-β signaling pathway in colon carcinogenesis and status of curcumin as chemopreventive strategy. Tumor Biol. 35:7295–7305.
   PubMed Web of Science ®Google Scholar
• Rana, C., Piplani, H., Vaish, V., Nehru, B. and Sanyal, S. N. (2015). Downregulation of PI3-K/Akt/PTEN pathway and activation of mitochondrial intrinsic apoptosis by Diclofenac and Curcumin in colon cancer. Mol. Cell. Biochem. 402:225–241.
   PubMed Web of Science ®Google Scholar
• Ranjan, D., Johnston, T. D., Reddy, K. S., Wu, G., Bondada, S. and Chen, C. (1999). Enhanced apoptosis mediates inhibition of EBV-transformed lymphoblastoid cell line proliferation by curcumin. J.Surg. Res. 87:1–5.
   PubMed Web of Science ®Google Scholar
• Rao, C. V., Simi, B. and Reddy, B. S. (1993). Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis. 14:2219–2225.
   PubMed Web of Science ®Google Scholar
• Rastogi, L., Patnaik, G. K. and Dikshit, M. (1998). Free radicals and antioxidant status following pylorus ligation induced gastric mucosal injury in rats. Pharmacolo. Res. 38:125–132.
   PubMed Web of Science ®Google Scholar
• Reddy, A. C. P. and Lokesh, B. R. (1994). Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Mol. Cell. Biochem. 137:1–8.
   PubMed Web of Science ®Google Scholar
• Roy, M., Chakraborty, S., Siddiqi, M. and Bhattacharya, R. K. (2002). Induction of apoptosis in tumor cells by natural phenolic compounds. Asian Pac. J. Cancer Prev. 3:61–67.
   PubMedGoogle Scholar
• Roy, M. and Mukherjee, S. (2014). Reversal of resistance towards cisplatin by curcumin in cervical cancer cells. Asian Pac. J. Cancer Prev. 15:1403–1410.
   PubMedGoogle Scholar
• Roy, M., Mukherjee, S., Sarkar, R. and Biswas, J. (2011). Curcumin sensitizes chemotherapeutic drugs via modulation of PKC, telomerase, NF-κB and HDAC in breast cancer. Ther. Deliv. 2:1275–1293.
   PubMedGoogle Scholar
• Sahu, R. P., Batra, S. and Srivastava, S. K. (2009). Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. Br. J. Cancer. 100:1425–1433.
   PubMed Web of Science ®Google Scholar
• Saini, S., Arora, S., Majid, S., Shahryari, V., Chen, Y., Deng, G., Yamamura, S., Ueno, K. and Dahiya, R. (2011). Curcumin modulates MicroRNA-203–mediated regulation of the Src-Akt Axis in bladder cancer. Cancer Prev. Res. 4:1698–1709.
   PubMed Web of Science ®Google Scholar
• Salvioli, S., Sikora, E., Cooper, E. L. and Franceschi, C. (2007). Curcumin in cell death processes: A challenge for CAM of age-related pathologies. Evidence-Based Complement. Alternat. Med. 4:181–190.
   PubMed Web of Science ®Google Scholar
• Samaha, H. S., Kelloff, G. J., Steele, V., Rao, C. V. and Reddy, B. S. (1997). Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: Apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res. 57:1301–1305.
   PubMed Web of Science ®Google Scholar
• Sandhya, B., Thomas, S., Isabel, W. and Shenbagarathai, R. (2005). Ethnomedicinal plants used by the valaiyan community of piranmalai hills (reserved forest), tamilnadu, India. A pilot study. Afr. J. Tradit. Complement. Altern. Med. 3:101–114.
   Google Scholar
• Sandur, S. K., Pandey, M. K., Sung, B., Ahn, K. S., Murakami, A., Sethi, G., Limtrakul, P., Badmaev, V. and Aggarwal, B. B. (2007). Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis. 28:1765–1773.
   PubMed Web of Science ®Google Scholar
• Saydmohammed, M., Joseph, D. and Syed, V. (2010). Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells. J. Cell. Biochem. 110:447–456.
   PubMed Web of Science ®Google Scholar
• Schmitz, M. L., Mattioli, I., Buss, H. and Kracht, M. (2004). NF-κB: A multifaceted transcription factor regulated at several levels. Chembiochem: A Eur. J. Chem. Biol. 5:1348–1358.
   PubMed Web of Science ®Google Scholar
• Sehgal, G., Hua, J., Bernhard, E. J., Sehgal, I., Thompson, T. C. and Muschel, R. J. (1998). Requirement for matrix metalloproteinase-9 (gelatinase B) expression in metastasis by murine prostate carcinoma. Am. J. Pathol. 152:591.
   PubMed Web of Science ®Google Scholar
• Shakibaei, M., Buhrmann, C., Kraehe, P., Shayan, P., Lueders, C. and Goel, A. (2014). Curcumin chemosensitizes 5-Fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures. PloS One. 9:e85397.
   PubMed Web of Science ®Google Scholar
• Shakor, A. B. A., Atia, M., Ismail, I. A., Alshehri, A., El-Refaey, H., Kwiatkowska, K. and Sobota, A. (2014). Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation. Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids. 1841:1672–1682.
   PubMed Web of Science ®Google Scholar
• Sharma, S., Chopra, K. and Kulkarni, S. K. (2007). Effect of insulin and its combination with resveratrol or curcumin in attenuation of diabetic neuropathic pain: Participation of nitric oxide and TNF-alpha. Phytother. Res. 21:278–283.
   PubMed Web of Science ®Google Scholar
• Shen, F., Cai, W.-S., Li, J.-L., Feng, Z., Liu, Q.-C., Xiao, H.-Q., Cao, J. and Xu, B. (2014). Synergism from the combination of ulinastatin and curcumin offers greater inhibition against colorectal cancer liver metastases via modulating matrix metalloproteinase-9 and E-cadherin expression. Onco Targets Ther. 7:305–314.
   PubMed Web of Science ®Google Scholar
• Shih, C.-A. and Lin, J.-K. (1993). Inhibition of 8-hydroxydeoxyguanosine formation by curcumin in mouse fibroblast cells. Carcinogenesis. 14:709–712.
   PubMed Web of Science ®Google Scholar
• Shiri, S., Alizadeh, A. M., Baradaran, B., Farhanghi, B., Shanehbandi, D., Khodayari, S., Khodayari, H. and Tavassoli, A. (2015). Dendrosomal curcumin suppresses metastatic breast cancer in mice by changing m1/m2 macrophage balance in the tumor microenvironment. Asian Pac. J. Cancer Prev. 16:3917–3922.
   PubMedGoogle Scholar
• Shishodia, S. (2005). Curcumin: Getting back to the roots. Annal. New York Acad. Sci. 1056:206–217.
   PubMed Web of Science ®Google Scholar
• Shklar, G. and Schwartz, J. (1993). Oral cancer inhibition by micronutrients. The experimental basis for clinical trials. Eur. J. Cancer Part B: Oral Oncol. 29:9–16.
   Web of Science ®Google Scholar
• Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R. and Srinivas, P. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica. 64:353–356.
   PubMed Web of Science ®Google Scholar
• Shu, L., Khor, T. O., Lee, J.-H., Boyanapalli, S. S. S., Huang, Y., Wu, T.-Y., Saw, C. L. L., Cheung, K.-L. and Kong, A.-N. T. (2011). Epigenetic CpG demethylation of the promoter and reactivation of the expression of neurog1 by curcumin in prostate LNCaP cells. The AAPS J. 13:606–614.
   PubMed Web of Science ®Google Scholar
• Shuai, K. and Liu, B. (2005). Regulation of gene-activation pathways by PIAS proteins in the immune system. Nature Rev.: Immunol. 5:593–605.
   PubMed Web of Science ®Google Scholar
• Si, X., Wang, Y., Wong, J., Zhang, J., McManus, B. M. and Luo, H. (2007). Dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus B3 replication. J. Virol. 81:3142–3150.
   PubMed Web of Science ®Google Scholar
• Sidhu, G. S., Singh, A. K., Thaloor, D., Banaudha, K. K., Patnaik, G. K., Srimal, R. C. and Maheshwari, R. K. (1998). Enhancement of wound healing by curcumin in animals. Wound Repair Regen. 6:167–177.
   PubMedGoogle Scholar
• Sikora, E., Bielak-Zmijewska, A., Piwocka, K., Janusz, S. and Radziszewska, E. (1997). Inhibition of proliferation and apoptosis of human and rat T lymphocytes by curcumin, a curry pigment. Bioch. Pharmacol. 54:899–907.
   PubMed Web of Science ®Google Scholar
• Sindhwani, P., Hampton, J. A., Baig, M., Keck, R. and Selman, S. H. (2000). Curcumin: A food spice with cytotoxic activity against urinary bladder cancer. J. Am. College Surgeons. 191:S94–S95.
   Google Scholar
• Singh, M. and Singh, N. (2009). Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells. Mol. Cell. Biochem. 325:107–119.
   PubMed Web of Science ®Google Scholar
• Singh, M. and Singh, N. (2010). Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells. Mol. Cell. Biochem. 347:1–11.
   PubMed Web of Science ®Google Scholar
• Singh, R. P., Dhanalakshmi, S. and Agarwal, R. (2002). Phytochemicals as cell cycle modulators a less toxic approach in halting human cancers. Cell Cycle. 1:155–160.
   Web of Science ®Google Scholar
• Singh, S. and Aggarwal, B. B. (1995). Activation of transcription factor NF- B Is suppressed by Curcumin (Diferuloylmethane). J. Biol. Chem. 270:24995–25000.
   PubMed Web of Science ®Google Scholar
• Song, M., Zang, W., Zhang, B., Cao, J. and Yang, G. (2012). GCS overexpression is associated with multidrug resistance of human HCT-8 colon cancer cells. J. Exp. Clin. Cancer Res. 31:23.
   PubMed Web of Science ®Google Scholar
• Squires, M. S., Hudson, E. A., Howells, L., Sale, S., Houghton, C. E., Jones, J. L., Fox, L. H., Dickens, M., Prigent, S. A. and Manson, M. M. (2003). Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells. Biochem. Pharmacol. 65:361–376.
   PubMed Web of Science ®Google Scholar
• Sreejayan,   and Rao, M. N. A. (1997). Nitric oxide scavenging by curcuminoids. J. Pharm. Pharmacol. 49:105–107.
   PubMed Web of Science ®Google Scholar
• Sreekanth, C. N., Bava, S. V., Sreekumar, E. and Anto, R. J. (2011). Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer. Oncogene. 30:3139–3152.
   PubMed Web of Science ®Google Scholar
• Starr, R. and Hilton, D. J. (1999). Negative regulation of the JAK/STAT pathway. Bioessays. 21:47–52.
   PubMed Web of Science ®Google Scholar
• Sun, Y., Du, L., Liu, Y., Li, X., Li, M., Jin, Y. and Qian, X. (2014). Transdermal delivery of the in situ hydrogels of curcumin and its inclusion complexes of hydroxypropyl-β-cyclodextrin for melanoma treatment. Int. J. Pharmaceutics. 469:31–39.
   PubMed Web of Science ®Google Scholar
• Surh, Y.-J. (2003). Cancer chemoprevention with dietary phytochemicals. Nature Rev. Cancer. 3:768–780.
   PubMed Web of Science ®Google Scholar
• Syng-ai, C., Kumari, A. L. and Khar, A. (2004). Effect of curcumin on normal and tumor cells: Role of glutathione and bcl-2. Mol. Cancer Ther. 3:1101–1108.
   PubMed Web of Science ®Google Scholar
• Tanaka, J., Yuda, Y., Inouye, S. and Yamakawa, T. (2001). The role of nitric oxide in the gastric acid secretion induced by ischemia–reperfusion in the pylorus-ligated rat. Eur. J. Pharmacol. 424:69–74.
   PubMed Web of Science ®Google Scholar
• Thacker, P. C. and Karunagaran, D. (2015). Curcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells. PloS One. 10:e0120045.
   PubMed Web of Science ®Google Scholar
• Thangapazham, R. L., Singh, A. K., Sharma, A., Warren, J., Gaddipati, J. P. and Maheshwari, R. K. (2007). Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo. Cancer Lett. 245:232–241.
   PubMed Web of Science ®Google Scholar
• Tharakan, S. T., Inamoto, T., Sung, B., Aggarwal, B. B. and Kamat, A. M. (2010). RETRACTED: Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers. Biochem. Pharmacol. 79:218–228.
   PubMed Web of Science ®Google Scholar
• Tian, B., Wang, Z., Zhao, Y., Wang, D., Li, Y., Ma, L., Li, X., Li, J., Xiao, N., Tian, J. and Rodriguez, R. (2008). Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model. Cancer Lett. 264:299–308.
   PubMed Web of Science ®Google Scholar
• Tian, K.-L., Yu, W.-G., Ren, G.-J., Yuan, H.-Q., Xu, G., Xu, X. and Qi, X.-L. (2011). Preventive action of curcumin in experimental acute pancreatitis in mouse. Indian J. Med. Res. 134:717.
   PubMedGoogle Scholar
• Toden, S., Okugawa, Y., Jascur, T., Wodarz, D., Komarova, N. L., Buhrmann, C., Shakibaei, M., Boland, C. R. and Goel, A. (2015). Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis. 36:355–367.
   PubMed Web of Science ®Google Scholar
• Tønnesen, H. H., Másson, M. and Loftsson, T. (2002). Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: Solubility, chemical and photochemical stability. Int. J. Pharmaceutics. 244:127–135.
   PubMed Web of Science ®Google Scholar
• Trudel, D., Fradet, Y., Harel, F., Meyer, F. and Têtu, B. (2004). Corrélations entre la protéase MMP-2, l'activateur MT1-MMP et l'inhibiteur TIMP-2 dans le cancer de la prostate. Annal. Pathologie. 24:98.
   Google Scholar
• Uchida, K. and Kawakishi, S. (1990). Cimetidine anti-ulcer drug as a powerful hydroxyl radical scavenger. Agric. Biol. Chem. 54:24850–2487.
   Google Scholar
• Uehara, Y., Inoue, M., Fukuda, K., Yamakoshi, H., Hosoi, Y., Kanda, H., Oshima, M., Iwabuchi, Y. and Shibata, H. (2014). Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo. Gastric Cancer. 18:774–783.
   PubMed Web of Science ®Google Scholar
• Valentini, A., Conforti, F., Crispini, A., De Martino, A., Condello, R., Stellitano, C., Rotilio, G., Ghedini, M., Federici, G., Bernardini, S. and Pucci, D. (2009). Synthesis, oxidant properties, and antitumoral effects of a heteroleptic palladium(II) complex of curcumin on human prostate cancer cells. J. Med. Chem. 52:484–491.
   PubMed Web of Science ®Google Scholar
• Vishvakarma, N. K., Kumar, A., Kumar, A., Kant, S., Bharti, A. C. and Singh, S. M. (2012). Myelopotentiating effect of curcumin in tumor-bearing host: Role of bone marrow resident macrophages. Toxicol. Appl. Pharmacol. 263:111–121.
   PubMed Web of Science ®Google Scholar
• Waghela, B. N., Sharma, A., Dhumale, S., Pandey, S. M. and Pathak, C. (2015). Curcumin conjugated with PLGA potentiates sustainability, anti-proliferative activity and apoptosis in human colon carcinoma cells. PloS One. 10:e0117526.
   PubMed Web of Science ®Google Scholar
• Wahl, H., Tan, L., Griffith, K., Choi, M. and Liu, J. (2007). Curcumin enhances Apo2L/TRAIL-induced apoptosis in chemoresistant ovarian cancer cells. Gynecologic Oncol. 105:104–112.
   PubMed Web of Science ®Google Scholar
• Wang, K., Fan, H., Chen, Q., Ma, G., Zhu, M., Zhang, X., Zhang, Y. and Yu, J. (2015). Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro. Anti-Cancer Drugs. 26:15–24.
   PubMed Web of Science ®Google Scholar
• Watanabe, F. T., Chade, D. C., Reis, S. T., Piantino, C., Dall'Oglio, M. F., Srougi, M. and Leite, K. R. (2011). Curcumin, but not Prima-1, decreased tumor cell proliferation in the syngeneic murine orthotopic bladder tumor model. Clinics. 66:2121–2124.
   PubMed Web of Science ®Google Scholar
• Webster, T. J., Sun, L. and Chang, K. (2014). Short communication: Selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts. Int. J. Nanomedicine. 9:461.
   PubMed Web of Science ®Google Scholar
• Wei, S.-C., Lin, Y.-S., Tsao, P.-N., Wu-Tsai, J.-J., Wu, C. and Wong, J.-M. (2004). Comparison of the anti-proliferation and apoptosis-induction activities of sulindac, celecoxib, curcumin, and nifedipine in mismatch repair-deficient cell lines. J. Formos. Med. Assoc. 103:599–606.
   PubMed Web of Science ®Google Scholar
• Wible, B. A., Wang, L., Kuryshev, Y. A., Basu, A., Haldar, S. and Brown, A. M. (2002). Increased K+ efflux and apoptosis induced by the potassium channel modulatory protein KChAP/PIAS3 in prostate cancer cells. J. Biol. Chem. 277:17852–17862.
   PubMed Web of Science ®Google Scholar
• Wilken, R., Veena, M. S., Wang, M. B. and Srivatsan, E. S. (2011). Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol. Cancer. 10:12.
   PubMed Web of Science ®Google Scholar
• Willett, W. C. (2001). Diet and breast cancer. J. Internal Med. 249:395–411.
   Web of Science ®Google Scholar
• Wolanin, K. (2006). Curcumin affects components of the chromosomal passenger complex and induces mitotic catastrophe in apoptosis-resistant Bcr-Abl-Expressing cells. Mol. Cancer Res. 4:457–469.
   PubMed Web of Science ®Google Scholar
• Wong, T. F., Takeda, T., Li, B., Tsuiji, K., Kitamura, M., Kondo, A. and Yaegashi, N. (2011). Curcumin disrupts uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition. Gynecol. Oncol. 122:141–148.
   PubMed Web of Science ®Google Scholar
• Wu, J., Cai, Z., Wei, X., Chen, M., Ying, S., Shi, L., Xu, R.-A., He, F., Liang, G. and Zhang, X. (2015). Anti-lung cancer activity of the curcumin analog JZ534 in vitro. BioMed. Res. Int. 2015:1–10.
   Web of Science ®Google Scholar
• Xi, Y., Gao, H., Callaghan, M. U., Fribley, A. M., Garshott, D. M., Xu, Z.-X., Zeng, Q. and Li, Y.-L. (2015). Induction of BCL2-interacting killer, BIK, is mediated for anti-cancer activity of curcumin in human head and neck squamous cell carcinoma cells. J. Cancer. 6:327–332.
   PubMed Web of Science ®Google Scholar
• Xu, B., Shen, F., Cai, W.-S., Li, J.-L., Feng, Z., Liu, Q.-C., Xiao, H.-Q. and Cao, J. (2014). Synergism from the combination of ulinastatin and curcumin offers greater inhibition against colorectal cancer liver metastases via modulating matrix metalloproteinase-9 and E-cadherin expression. OncoTargets Therapy. 7:305–314.
   PubMed Web of Science ®Google Scholar
• Yallapu, M. M., Khan, S., Maher, D. M., Ebeling, M. C., Sundram, V., Chauhan, N., Ganju, A., Balakrishna, S., Gupta, B. K., Zafar, N., Jaggi, M. and Chauhan, S. C. (2014). Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer. Biomaterials. 35:8635–8648.
   PubMed Web of Science ®Google Scholar
• Yamaguchi, M., Zhu, S., Weitzmann, M. N., Snyder, J. P. and Shoji, M. (2014). Curcumin analog UBS109 prevents bone marrow osteoblastogenesis and osteoclastogenesis disordered by coculture with breast cancer MDA-MB-231 bone metastatic cells in vitro. Mol. Cell. Biochem. 401:1–10.
   PubMed Web of Science ®Google Scholar
• Yamazaki, C., Hoshino, J., Sekiguchi, T., Hori, Y., Miyauchi, S., Mizuno, S. and Horie, K. (1998). Production of superoxide and nitric oxide by alveolar macrophages in the bleomycin-induced interstitial pneumonia mice model. Japan. J. Pharmacol. 78:69–73.
   PubMedGoogle Scholar
• Yan, L. (2013). Abstract B77: Curcumin deteriorates trabecular and cortical bone in mice bearing metastatic Lewis lung carcinoma. Cancer Res. 73:B77–B77.
   Web of Science ®Google Scholar
• Yang, J.-S. (2013). Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway. Int. J. Oncol. 44 (1).
   Web of Science ®Google Scholar
• Ye, M., Zhang, J., Zhang, J., Miao, Q., Yao, L. and Zhang, J. (2015). Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer. Cancer Lett. 357:196–205.
   PubMed Web of Science ®Google Scholar
• Yip-Schneider, M. T. (2000). Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. Carcinogenesis. 21:139–146.
   PubMed Web of Science ®Google Scholar
• Yip, I., Heber, D. and Aronson, W. (1999). Nutrition and prostate cancer. Urologic Clinics North America. 26:403–411.
   PubMed Web of Science ®Google Scholar
• Young, N. A., Bruss, M. S., Gardner, M., Willis, W. L., Mo, X., Valiente, G. R., Cao, Y., Liu, Z., Jarjour, W. N. and Wu, L.-C. (2014). Oral administration of nano-emulsion curcumin in mice suppresses inflammatory-induced NFκB signaling and macrophage migration. PloS One. 9:e111559.
   PubMed Web of Science ®Google Scholar
• Youns, M. and Fathy, G. M. (2013). Upregulation of extrinsic apoptotic pathway in curcumin‐mediated antiproliferative effect on human pancreatic carcinogenesis. J. Cell. Biochem. 114:2654–2665.
   PubMed Web of Science ®Google Scholar
• Yoysungnoen, B., Bhattarakosol, P., Patumraj, S. and Changtam, C. (2015). Effects of tetrahydrocurcumin on hypoxia-inducible factor-1αand vascular endothelial growth factor expression in cervical cancer cell-induced angiogenesis in nude mice. BioMed. Res. Int. 2015:1–11.
   Web of Science ®Google Scholar
• Yu, A. E., Hewitt, R. E., Connor, E. W. and Stetler-Stevenson, W. G. (1997). Matrix Metalloproteinases. Drugs Aging. 11:229–244.
   PubMed Web of Science ®Google Scholar
• Yu, Z. and Shah, D. M. (2007). Curcumin down-regulates Ets-1 and Bcl-2 expression in human endometrial carcinoma HEC-1-A cells. Gynecol. Oncol. 106:541–548.
   PubMed Web of Science ®Google Scholar
• Zafar, S. S., Hampton, J., Keck, R. and Selman, S. (2003). Curcumin prevents AY27 bladder transitional cell tumor growth in Fisher 344 rats. J. Urology. 169:194–194.
   Web of Science ®Google Scholar
• Zaidi, S. F. H., Yamada, K., Kadowaki, M., Usmanghani, K. and Sugiyama, T. (2009). Bactericidal activity of medicinal plants, employed for the treatment of gastrointestinal ailments, against Helicobacter pylori. J. Ethnopharmacol. 121:286–291.
   PubMed Web of Science ®Google Scholar
• Zhan, Y., Chen, Y., Liu, R., Zhang, H. and Zhang, Y. (2013). Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling. Arch. Pharmacal Res. 37:1086–1095.
   PubMed Web of Science ®Google Scholar
• Zhang, L., Shi, J., Feng, J., Klocker, H., Lee, C. and Zhang, J. (2004). Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer. Prostate Cancer Prostatic Diseases. 7:327–332.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Lee, T. C., Guillemin, B., Yu, M.-C. and Rom, W. N. (1993). Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. J. Immunol. 150:4188–4196.
   PubMed Web of Science ®Google Scholar
• Zhao, Z., Li, C., Xi, H., Gao, Y. and Xu, D. (2015). Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathway. Mol. Med. Rep. 12:5415–5422.
   PubMed Web of Science ®Google Scholar
• Zhen, L., Fan, D., Yi, X., Cao, X., Chen, D. and Wang, L. (2014). Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways. Int. J. Clin. Exp. Pathol. 7:6438.
   PubMed Web of Science ®Google Scholar
• Zheng, L., Tong, Q. and Wu, C. (2002). Inhibitory effects of curcumin on apoptosis of human ovary cancer cell line A2780 and its molecular mechanism. Ai zheng= Aizheng= Chin. J. Cancer. 21:1296–1300.
   PubMedGoogle Scholar
• Zhou, G., Cao, F., Chang, J., Sun, G. and Chen, X. (2014). Mechanism of curcumin analog MHMD-induced cell death in A549 lung cancer cells. Eur. Rev. Med. Pharmacolo. Sci. 18:3134–3138.
   PubMed Web of Science ®Google Scholar
• Zhou, G.-Z., Cao, F.-K. and Du, S.-W. (2015). The apoptotic pathways in the curcumin analog MHMD-induced lung cancer cell death and the essential role of actin polymerization during apoptosis. Biomed. Pharmacother. 71:128–134.
   PubMed Web of Science ®Google Scholar
• Zhou, Q., Su, S., Zhang, H. and Lu, Y. (2009). Regulation of protein kinases on signal pathway in breast cancer cell MCF-7 by curcumin. Zhong yao cai= Zhongyaocai= J. Chin. Med. Mater. 32:728–732.
   PubMedGoogle Scholar
• Zhu, D.-J., Chen, X.-W., Wang, J.-Z., Ju, Y.-L., Ou Yang, M. and Zhang, W.-J. (2013). Proteomic analysis identifies proteins associated with curcumin-enhancing efficacy of irinotecan-induced apoptosis of colorectal cancer LOVO cell. Int. J. Clin. Exp. Pathol. 7:1–15.
   PubMed Web of Science ®Google Scholar
• Zou, P., Zhang, J., Xia, Y., Kanchana, K., Guo, G., Chen, W., Huang, Y., Wang, Z., Yang, S. and Liang, G. (2015). ROS generation mediates the anti-cancer effects of WZ35 via activating JNK and ER stress apoptotic pathways in gastric cancer. Oncotarget. 6:5860–5876.
   PubMed Web of Science ®Google Scholar