1,626
Views
49
CrossRef citations to date
0
Altmetric
Articles

Metabolomics-assisted biotechnological interventions for developing plant-based functional foods and nutraceuticals

ORCID Icon, ORCID Icon, ORCID Icon, , , , & ORCID Icon show all

References

  • Afendi, F. M., Okada, T., Yamazaki, M., Hirai-Morita, A., Nakamura, Y., Nakamura, K., Ikeda, S., Takahashi, H., Altaf-Ul-Amin, M. and Darusman, L. K. (2012). KNApSAcK family databases: integrated metabolite–plant species databases for multifaceted plant research. Plant Cell Physiol. 53(2):e1–e1.
  • Ahn, J. H., Kim, E. S., Lee, C., Kim, S., Cho, S. H., Hwang, B. Y. and Lee, M. K. (2013). Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects. Bioorg. Med. Chem. Lett. 23(12):3604–3608.
  • Allwood, J. W. and Goodacre, R. (2010). An introduction to liquid chromatography–mass spectrometry instrumentation applied in plant metabolomic analyses. Phytochem. Anal. 21(1):33–47.
  • Al-Taweel, A. M., Perveen, S., El-Shafae, A. M., Fawzy, G. A., Malik, A., Afza, N., Iqbal, L. and Latif, M. (2012). Bioactive phenolic amides from Celtis africana. Molecules 17(3):2675–2682.
  • Asif, M. (2011). Health effects of omega-3, 6, 9 fatty acids: Perilla frutescens is a good example of plant oils. Orient. Pharm. Exp. Med. 11(1):51–59.
  • Atal, S., Agrawal, R. P., Vyas, S., Phadnis, P. and Rai, N. (2012). Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice. Acta Pol. Pharm. 69(5):965–969.
  • Azuma, A., Kobayashi, S., Mitani, N., Shiraishi, M., Yamada, M., Ueno, T., Kono, A., Yakushiji, H. and Koshita, Y. (2008). Genomic and genetic analysis of Myb-related genes that regulate anthocyanin biosynthesis in grape berry skin. Theor. Appl. Genet. 117(6):1009–1019.
  • Bagchi, D., Swaroop, A. and Bagchi, M. (2015). Genomics, proteomics and metabolomics in nutraceuticals and functional foods. In: pp. 3–338. Bagchi, D, Lau, FC and Bagchi, M, eds., Wiley-Blackwell. John Wiley & Sons, Ames.
  • Bailey, L. B., Rampersaud, G. C. and Kauwell, G. P. (2003). Folic acid supplements and fortification affect the risk for neural tube defects, vascular disease and cancer: evolving science. J. Nutr. 133(6):1961S–1968S.
  • Bailly, F. and Cotelle, P. (2005). Anti-HIV activities of natural antioxidant caffeic acid derivatives: toward an antiviral supplementation diet. Curr. Med. Chem. 12(15):1811–1818.
  • Beckman, C. H. (2000). Phenolic-storing cells: keys to programmed cell death and periderm formation in wilt disease resistance and in general defence responses in plants? Physiol. Mol. Plant P. 57(3):101–110.
  • Belury, M. A. (2002a). Dietary conjugated linoleic acid in health: Physiological effects and mechanisms of action. Annu. Rev. Nutr. 22(1):505–531.
  • Belury, M. A. (2002b). Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. J. Nutr. 132(10):2995–2998.
  • Bhargava, U. C. and Westfall, B. A. (1969). The mechanism of blood pressure depression by ellagic acid. Exp. Biol. Med. 132(2):754–756.
  • Biais, B., Beauvoit, B., Allwood, J. W., Deborde, C., Maucourt, M., Goodacre, R., Rolin, D. and Moing, A. (2010). Metabolic acclimation to hypoxia revealed by metabolite gradients in melon fruit. J. Plant Physiol. 167(3):242–245.
  • Bloedon, L. T., Balikai, S., Chittams, J., Cunnane, S. C., Berlin, J. A., Rader, D. J. and Szapary, P. O. (2008). Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. J. Am. Coll. Nutr. 27(1):65–74.
  • Boccard, J., Veuthey, J. L. and Rudaz, S. (2010). Knowledge discovery in metabolomics: an overview of MS data handling. J. Sep. Sci. 33(3):290–304.
  • Bollina, V., Kumaraswamy, G. K., Kushalappa, A. C., Choo, T. M., Dion, Y., Rioux, S., Faubert, D. and Hamzehzarghani, H. (2010). Mass spectrometry‐based metabolomics application to identify quantitative resistance‐related metabolites in barley against Fusarium head blight. Mol. Plant Pathol. 11(6):769–782.
  • Bonawitz, N. D., Soltau, W. L., Blatchley, M. R., Powers, B. L., Hurlock, A. K., Seals, L. A., Weng, J.-K., Stout, J. and Chapple, C. (2012). REF4 and RFR1, subunits of the transcriptional coregulatory complex mediator, are required for phenylpropanoid homeostasis in Arabidopsis. J. Biol. Chem. 287(8):5434–5445.
  • Borgeat, P., Hamberg, M. and Samuelsson, B. (1976). Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases. J. Biol. Chem. 251(24):7816–7820.
  • Boz, H. (2015). p‐Coumaric acid in cereals: presence, antioxidant and antimicrobial effects. Int. J. Food Sci. Tech. 50(11):2323–2328.
  • Bratt, K., Sunnerheim, K., Bryngelsson, S., Fagerlund, A., Engman, L., Andersson, R. E. and Dimberg, L. H. (2003). Avenanthramides in oats (Avena sativa L.) and structure-antioxidant activity relationships. J. Agric. Food Chem. 51(3):594–600.
  • Breitling, R., Pitt, A. R. and Barrett, M. P. (2006). Precision mapping of the metabolome. Trends Biotechnol. 24(12):543–548.
  • Brenna, J. T., Varamini, B., Jensen, R. G., Diersen-Schade, D. A., Boettcher, J. A. and Arterburn, L. M. (2007). Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am. J. Clin. Nutr. 85(6):1457–1464.
  • Brown, C. (2005). Antioxidants in potato. Am. J. Potato Res. 82(2):163–172.
  • Butelli, E., Titta, L., Giorgio, M., Mock, H.-P., Matros, A., Peterek, S., Schijlen, E. G., Hall, R. D., Bovy, A. G. and Luo, J. (2008). Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nat. Biotechnol. 26(11):1301–1308.
  • Cao, Y. and Cao, R. (1999). Angiogenesis inhibited by drinking tea. Nature 398(6726):381–381.
  • Cartea, M. E. and Velasco, P. (2008). Glucosinolates in Brassica foods: bioavailability in food and significance for human health. Phytochem. Rev. 7(2):213–229.
  • Caspi, R., Altman, T., Dale, J. M., Dreher, K., Fulcher, C. A., Gilham, F., Kaipa, P., Karthikeyan, A. S., Kothari, A. and Krummenacker, M. (2010). The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases. Nucleic Acids Res. 38(suppl 1):D473–D479.
  • Chao, C. Y., Mong, M. C., Chan, K. C. and Yin, M. C (2010). Anti‐glycative and anti‐inflammatory effects of caffeic acid and ellagic acid in kidney of diabetic mice. Mol. Nutr. Food Res. 54(3):388–395.
  • Chung, K.-T., Wei, C.-I. and Johnson, M. G. (1998). Are tannins a double-edged sword in biology and health? Trends Food Sci. Technol. 9(4):168–175.
  • Cornish, S. M., Chilibeck, P. D., Paus-Jennsen, L., Biem, H. J., Khozani, T., Senanayake, V., Vatanparast, H., Little, J. P., Whiting, S. J. and Pahwa, P. (2009). A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults. Appl. Physiol. Nutr. Metab. 34(2):89–98.
  • Cotterchio, M., Boucher, B. A., Manno, M., Gallinger, S., Okey, A. and Harper, P. (2006). Dietary phytoestrogen intake is associated with reduced colorectal cancer risk. J. Nutr. 136(12):3046–3053.
  • Dai, J. and Mumper, R. J. (2010). Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 15(10):7313–7352.
  • Dang, T. T. T., Onoyovwi, A., Farrow, S. C. and Facchini, P. J. (2012). Biochemical genomics for gene discovery in benzylisoquinoline alkaloid biosynthesis in opium poppy and related species. Methods Enzymol. 515:231.
  • De Vos, R. C., Moco, S., Lommen, A., Keurentjes, J. J., Bino, R. J. and Hall, R. D. (2007). Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry. Nat. Protoc. 2(4):778–791.
  • DeFelice, S. L. (1995). The nutraceutical revolution: its impact on food industry R&D. Trends Food Sci. Technol. 6(2):59–61.
  • Dillard, C. J. and German, J. B. (2000). Phytochemicals: nutraceuticals and human health. J. Sci. Food Agric. 80(12):1744–1756.
  • Dobson, G., Shepherd, T., Verrall, S. R., Conner, S., McNicol, J. W., Ramsay, G., Shepherd, L. V. T., Davies, H. V. and Stewart, D. (2008). Phytochemical diversity in tubers of potato cultivars and landraces using a GC-MS metabolomics approach. J. Agric. Food Chem. 56(21):10280–10291. doi: 10.1021/jf801370b
  • Döring, A. S. and Petersen, M. (2014). Production of caffeic, chlorogenic and rosmarinic acids in plants and suspension cultures of Glechoma hederacea. Phytochem. Lett. 10:cxi–cxvii.
  • Dubouzet, J. G., Ishihara, A., Matsuda, F., Miyagawa, H., Iwata, H. and Wakasa, K. (2007). Integrated metabolomic and transcriptomic analyses of high-tryptophan rice expressing a mutant anthranilate synthase alpha subunit. J. Exp. Bot. 58(12):3309–3321.
  • Duthie, G. G., Duthie, S. J. and Kyle, J. A. (2000). Plant polyphenols in cancer and heart disease: Implications as nutritional antioxidants. Nutr. Res. Rev. 13(01):79–106.
  • Dykes, L. and Rooney, L. W. (2006). Sorghum and millet phenols and antioxidants. J. Cereal Sci. 44(3):236–251.
  • Eckardt, N. A. (2008). Heritability of the tomato fruit metabolome. Plant Cell 20(3):501–501.
  • Eliasson, M., Rannar, S. and Trygg, J. (2011). From data processing to multivariate validation-essential steps in extracting interpretable information from metabolomics data. Curr. Pharm. Biotechnol. 12(7):996–1004.
  • Ellis, D. I., Dunn, W. B., Griffin, J. L., Allwood, J. W. and Goodacre, R. (2007). Metabolic fingerprinting as a diagnostic tool. Pharmacogenomics 8(9):1243–1266.
  • Esvelt, K. M. and Wang, H. H. (2013). Genome-scale engineering for systems and synthetic biology. Mol. Syst. Biol. 9(1):641.
  • Fahey, J. W., Zhang, Y. and Talalay, P. (1997). Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. U. S. A. 94(19):10367–10372.
  • Fernie, A. R. and Schauer, N. (2009). Metabolomics-assisted breeding: A viable option for crop improvement? Trends Genet. 25(1):39–48.
  • Ferreyra, M. F., Rius, S. P. and Casati, P. (2012). Flavonoids: Biosynthesis, biological functions, and biotechnological applications. Front. Plant Sci. 3(222):1–15.
  • Fiehn, O. (2001). Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Comp. Funct. Genomics 2(3):155–168.
  • Fiehn, O. (2002). Metabolomics–the link between genotypes and phenotypes. Plant Mol. Biol. 48(1–2):155–171.
  • Fiehn, O., Wohlgemuth, G., Scholz, M., Kind, T., Lee, D. Y., Lu, Y., Moon, S. and Nikolau, B. (2008). Quality control for plant metabolomics: Reporting MSI‐compliant studies. Plant J. 53(4):691–704.
  • Finotti, E. and Di Majo, D. (2003). Influence of solvents on the antioxidant property of flavonoids. Food/Nahrung 47(3):186–187.
  • Franceschi, S., Bidoli, E., Vecchia, C. L., Talamini, R., D'Avanzo, B. and Negri, E. (1994). Tomatoes and risk of digestive-tract cancers. Int. J. Cancer 59(2):181–184.
  • Frankel, E. N., Waterhouse, A. L. and Teissedre, P. L. (1995). Principal phenolic phytochemicals in selected California wines and their antioxidant activity in inhibiting oxidation of human low-density lipoproteins. J. Agric. Food Chem. 43(4):890–894.
  • Fridman, E., Carrari, F., Liu, Y.-S., Fernie, A. R. and Zamir, D. (2004). Zooming in on a quantitative trait for tomato yield using interspecific introgressions. Science 305(5691):1786–1789.
  • Garrait, G., Jarrige, J. F., Blanquet, S., Beyssac, E., Cardot, J. M. and Alric, M. (2006). Gastrointestinal absorption and urinary excretion of trans-cinnamic and p-coumaric acids in rats. J. Agric. Food Chem. 54:2944–2950.
  • Gentilli, M., Mazoit, J. X., Bouaziz, H., Fletcher, D., Casper, R. F., Benhamou, D. and Savouret, J. F. (2001). Resveratrol decreases hyperalgesia induced by carrageenan in the rat hind paw. Life Sci. 68(11):1317–1321.
  • Ghimire, B. K., Seong, E. S., Goh, E. J., Kang, E. Y., Ahn, J. K., Yu, C. Y. and Chung, I. M. (2011). Improving antioxidant activity in transgenic Codonopsis lanceolata plants via overexpression of the γ-tocopherol methyltransferase (γ-tmt) gene. Plant Growth Regul. 63(1):1–6.
  • Ghimire, B. K., Seong, E. S., Lee, C. O., Lee, J. G., Yu, C. Y., Kim, S. H. and Chung, I. M. (2015). Improved antioxidant activity in transgenic Perilla frutescens plants via overexpression of the γ-tocopherol methyltransferase (γ-tmt) gene. Protoplasma 252(5):1285–1290.
  • Gibon, Y. and Rolin, D. (2012). Aspects of experimental design for plant metabolomics experiments and guidelines for growth of plant material. Methods Mol. Biol. 13–30.
  • Giovannucci, E., Ascherio, A., Rimm, E. B., Stampfer, M. J., Colditz, G. A. and Willett, W. C. (1995). Intake of carotenoids and retino in relation to risk of prostate cancer. J. Natl. Cancer Inst. 87(23):1767–1776.
  • Gondim Junior, M. G. C., Barros, R., Silva, F. R. d. and Vasconcelos, G. J. N. d. (2005). Occurence and biological aspects of the clitoria tree psyllid in Brazil. Sci. Agric. 62(3):281–285.
  • Goossens, A., Mertens, J., Pollier, J., Bossche, R. V., López-Vidriero, I. and Franco-Zorrilla, J. M. (2015). The bHLH transcription factors TSAR1 and TSAR2 regulate triterpene saponin biosynthesis in medicago truncatula. Plant Physiol. 01645–02015.
  • Gorham, J. (1989). Stilbenes and phenanthrenes. In: Methods in Plant Biochemistry, vol. 1, pp. 159–196. Harborne, J. B. (ed.), plant phenolics. Academic Press, London.
  • Halket, J. M., Waterman, D., Przyborowska, A. M., Patel, R. K. P., Fraser, P. D. and Bramley, P. M. (2005). Chemical derivatization and mass spectral libraries in metabolic profiling by GC/MS and LC/MS/MS. J. Exp. Bot. 56(410):219–243.
  • Hall, R. D. (2006). Plant metabolomics: From holistic hope, to hype, to hot topic. New Phytol. 169(3):453–468. doi: 10.1111/j.1469-8137.2005.01632.x
  • Han, J., Wang, H., Lundgren, A. and Brodelius, P. E. (2014). Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plants. Phytochemistry 102:89–96.
  • Harborne, J. B. (1999). Classes and functions of secondary products from plants. In: Chemicals from Plants—Perspectives on Plant Secondary Products, pp. 1–25. Walton, J. N. and Brown, D. E., Eds., Imperial College Press, London.
  • Harborne, J. B. and Baxter, H. (1993). Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants, Taylor & Francis Limited, United Kingdom.
  • Harjes, C. E., Rocheford, T. R., Bai, L., Brutnell, T. P., Kandianis, C. B., Sowinski, S. G., Stapleton, A. E., Vallabhaneni, R., Williams, M. and Wurtzel, E. T. (2008). Natural genetic variation in lycopene epsilon cyclase tapped for maize biofortification. Science 319(5861):330–333.
  • Harrigan, G. (2002). Metabolic profiling: pathways in drug discovery. Drug Discov. Today 7(6):351–352.
  • HealthCanada. (1998a). Nutraceuticals/functional foods and health claims on foods. HealthCanada, Policy paper, Section 2.2(ed, Ottawa).
  • HealthCanada. (1998b). Nutraceuticals/functional foods and health claims on foods. HealthCanada, Policy paper, Section 2.2 (ed, Ottawa).
  • Heinonen, S., Nurmi, T., Liukkonen, K., Poutanen, K., Wahala, K., Deyama, T., Nishibe, S. and Adlercreutz, H. (2001). In vitro metabolism of plant lignans: New precursors of mammalian lignans enterolactone and enterodiol. J. Agric. Food Chem. 49(7):3178–3186.
  • Hendriks, M. M., van Eeuwijk, F. A., Jellema, R. H., Westerhuis, J. A., Reijmers, T. H., Hoefsloot, H. C. and Smilde, A. K. (2011). Data-processing strategies for metabolomics studies. TrAC, Trends Anal. Chem. 30(10):1685–1698.
  • Hertog, M. G., Feskens, E. J., Hollman, P. C., Katan, M. B. and Kromhout, D. (1994). Dietary flavonoids and cancer risk in the Zutphen Elderly Study. Nutr. Cancer 22:175–184.
  • Hertog, M. G., Kromhout, D., Aravanis, C., Blackburn, H., Buzina, R., Fidanza, F., Giampaoli, S., Jansen, A., Menotti, A. and Nedeljkovic, S. (1995). Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med. 155(4):381–386.
  • Hertog, M., Sweetnam, P. M., Fehily, A. M., Elwood, P. C. and Kromhout, D. (1997). Antioxidant flavonols and ischemic heart disease in a Welsh population of men: The Caerphilly Study. Am. J. Clin. Nutr. 65(5):1489–1494.
  • Hichri, I., Barrieu, F., Bogs, J., Kappel, C., Delrot, S. and Lauvergeat, V. (2011). Recent advances in the transcriptional regulation of the flavonoid biosynthetic pathway. J. Exp. Bot. erq442.
  • Hollman, P. C. H. and Katan, M. (1999). Dietary flavonoids: Intake, health effects and bioavailability. Food Chem. Toxicol. 37(9):937–942.
  • Hooper, L. and Cassidy, A. (2006). A review of the health care potential of bioactive compounds. J. Sci. Food Agric. 86(12):1805–1813.
  • Huang, S. S., Tsai, M. C., Chih, C. L., Hung, L. M. and Tsai, S. K. (2001). Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia. Life Sci. 69(9):1057–1065.
  • Hubner, R. and Houlston, R. (2008). Folate and colorectal cancer prevention. Br. J. Cancer 100(2):233–239.
  • Jaakola, L. (2013). New insights into the regulation of anthocyanin biosynthesis in fruits. Trends Plant Sci. 18(9):477–483.
  • Ji, L., Yogendra, K. N., Mosa, K. A., Kushalappa, A. C., Piñeros-Niño, C., Mosquera, T. and Narváez-Cuenca, C. E. (2016). Hydroxycinnamic acid functional ingredients and their biosynthetic genes in tubers of Solanum tuberosum Group Phureja. Cogent Food Agric. 2(1):1138595.
  • Jia, Q. and Chen, F. (2016). Catalytic functions of the isoprenyl diphosphate synthase superfamily in plants: A growing repertoire. Mol. Plant. 9(2):189–191.
  • Kadan, S., Saad, B., Sasson, Y. and Zaid, H. (2016). In vitro evaluation of anti-diabetic activity and cytotoxicity of chemically analysed Ocimum basilicum extracts. Food Chem. 196:1066–1074.
  • Kanani, H., Chrysanthopoulos, P. K. and Klapa, M. I. (2008). Standardizing GC–MS metabolomics. J. Chromatogr. B 871(2):191–201.
  • Kandaswami, C. and Middleton Jr, E. (1994). Free radical scavenging and antioxidant activity of plant flavonoids. In: Free Radicals in Diagnostic Medicine, pp. 351–376, Springer, US.
  • Kanehisa, M., Goto, S., Kawashima, S. and Nakaya, A. (2002). The KEGG databases at GenomeNet. Nucleic Acids Res. 30(1):42–46.
  • Karlsson, J., Emgard, M., Brundin, P. and Burkitt, M. J. (2000). Trans-resveratrol protects embryonic mesencephalic cells from tert-butyl hydroperoxide: Electron paramagnetic resonance spin trapping evidence for a radical scavenging mechanism. J. Neurochem. 75(1):141–150.
  • Katsuzaki, H., Kawakishi, S. and Osawa, T. (1994). Sesaminol glucosides in sesame seeds. Phytochemistry 35(3):773–776.
  • Kinoshita, T., Lepp, Z., Kawai, Y., Terao, J. and Chuman, H. (2006). An integrated database of flavonoids. BioFactors 26(3):179–188.
  • Kiziltepe, U., Turan, N. N., Han, U., Ulus, A. T. and Akar, F. (2004). Resveratrol, a red wine polyphenol, protects spinal cord from ischemia-reperfusion injury. J. Vasc. Surg. 40(1):138–145.
  • Kondratyuk, T. P. and Pezzuto, J. M. (2004). Natural product polyphenols of relevance to human health. Pharm. Biol. 42(sup1):46–63.
  • Kopka, J., Fernie, A., Weckwerth, W., Gibon, Y. and Stitt, M. (2004). Metabolite profiling in plant biology: Platforms and destinations. Genome Biol. 5(6):109.
  • Kumar, A., Kage, U., Mosa, K. and Dhokane, D. (2014). Metabolomics: A novel tool to bridge phenome to genome under changing climate to ensure food Security. Med. Aromat. Plants 3:e154.
  • Kumar, A., Yogendra, K. N., Karre, S., Kushalappa, A. C., Dion, Y. and Choo, T. M. (2016). WAX INDUCER1 (HvWIN1) transcription factor regulates free fatty acid biosynthetic genes to enforce cuticle to resist fusarium head blight in barley spikelets. J. Exp. Bot. erw187.
  • Kumaraswamy, G. K., Bollina, V., Kushalappa, A. C., Choo, T. M., Dion, Y., Rioux, S., Mamer, O. and Faubert, D. (2011). Metabolomics technology to phenotype resistance in barley against Gibberella zeae. Eur. J. Plant Pathol. 130(1):29–43.
  • Kuppusamy, U. R. and Das, N. P. (1993). Protective effects of tannic acid and related natural compounds on Crotalus adamenteus subcutaneous poisoning in mice. Pharmacol. Toxicol. 72(4–5):290–295.
  • Kusano, M., Redestig, H., Hirai, T., Oikawa, A., Matsuda, F., Fukushima, A., Arita, M., Watanabe, S., Yano, M. and Hiwasa-Tanase, K. (2011). Covering chemical diversity of genetically-modified tomatoes using metabolomics for objective substantial equivalence assessment. PLoS One 6(2):e16989.
  • Laaksonen, R., Katajamaa, M., Päivä, H., Sysi-Aho, M., Saarinen, L., Junni, P., Lütjohann, D., Smet, J., Van Coster, R. and Seppänen-Laakso, T. (2006). A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. PLoS One 1(1):e97.
  • Lamuela-Raventos, R. M., Romero-Perez, A. I., Waterhouse, A. L. and de la Torre-Boronat, M. C. (1995). Direct HPLC analysis of cis and trans-resveratrol and piceid isomers in Spanish red Vitis vinifera wines. J. Agric. Food Chem. 43(2):281–283.
  • Larqué, E., Sabater-Molina, M. and Zamora, S. (2007). Biological significance of dietary polyamines. Nutrition 23(1):87–95.
  • Lau, F. C., Bagchi, D., Zafra-Stone, S. and Bagchi, M. (2010). Recent advances in nutraceuticals and functional foods. In: Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods, vol. 1. Bagchi, D., Lau, F.C. and Bagchi, M., Eds., Wiley-Blackwell, Oxford, UK.
  • Lempereur, I., Rouau, X. and Abecassis, J. (1997). Genetic and agronomic variation in arabinoxylan and ferulic acid contents of durum wheat (Triticum durum L.) grain and its milling fractions. J. Cereal Sci. 25(2):103–110.
  • Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. A., Ruscetti, F. W. and Wang, J. M. (2000). Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem. Biophys. Res. Commun. 276(2):534–538.
  • Li, H., Flachowsky, H., Fischer, T. C., Hanke, M.-V., Forkmann, G., Treutter, D., Schwab, W., Hoffmann, T. and Szankowski, I. (2007). Maize Lc transcription factor enhances biosynthesis of anthocyanins, distinct proanthocyanidins and phenylpropanoids in apple (Malus domestica Borkh.). Planta 226(5):1243–1254.
  • Li, Y., Lin, Z., Huang, C., Zhang, Y., Wang, Z., Tang, Y.-j., Chen, T. and Zhao, X. (2015). Metabolic engineering of Escherichia coli using CRISPR–Cas9 meditated genome editing. Metab. Eng. 31:13–21.
  • Liu, C., Long, J., Zhu, K., Liu, L., Yang, W., Zhang, H., Li, L., Xu, Q. and Deng, X. (2016). Characterization of a citrus R2R3-MYB transcription factor that regulates the flavonol and hydroxycinnamic acid biosynthesis. Sci. Rep. doi: 10.1038/srep25352
  • Liu, J. H. and Qiu, A. Y. (2003). Application and extraction, purifying technology of chlorogenic acid [J]. J. Cereals Oils 9:017.
  • Lu, W., Bennett, B. D. and Rabinowitz, J. D. (2008). Analytical strategies for LC–MS-based targeted metabolomics. J. Chromatogr. B. 871:236–242.
  • Luo, J., Butelli, E., Hill, L., Parr, A., Niggeweg, R., Bailey, P., Weisshaar, B. and Martin, C. (2008). AtMYB12 regulates caffeoyl quinic acid and flavonol synthesis in tomato: Expression in fruit results in very high levels of both types of polyphenol. Plant J. 56(2):316–326.
  • Macheix, J.-J., Fleuriet, A. and Billot, J. (1990). Fruit Phenolics. CRC Press, Boca Raton, FL.
  • Manach, C., Scalbert, A., Morand, C., Rémésy, C. and Jiménez, L. (2004). Polyphenols: Food sources and bioavailability. Am. J. Clin. Nutri. 79(5):727–747.
  • Manach, C., Scalbert, A., Morand, C., Rémésy, C. and Jiménez, L. (2004). Polyphenols: Food sources and bioavailability. Am. J. Clin. Nutr. 79(5):727–747.
  • Martens, S., Preuß, A. and Matern, U. (2010). Multifunctional flavonoid dioxygenases: Flavonol and anthocyanin biosynthesis in Arabidopsis thaliana L. Phytochemistry 71(10):1040–1049.
  • Matsuda, F., Yonekura-Sakakibara, K., Niida, R., Kuromori, T., Shinozaki, K. and Saito, K. (2009). MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites. Plant J. 57(3):555–577.
  • Middleton, E., Kandaswami, C. and Theoharides, T. C. (2000). The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 52(4):673–751.
  • Mielecki, M. and Lesyng, B. (2016). Cinnamic acid derivatives as inhibitors of oncogenic protein kinases–structure, mechanisms and biomedical effects. Curr. Med. Chem. 23(10):954–982.
  • Mills, P. K., Beeson, W. L., Phillips, R. L. and Fraser, G. E. (1989). Cohort study of diet, lifestyle, and prostate cancer in Adventist men. Cancer 64(3):598–604.
  • Mo, H. and Elson, C. E. (1999). Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids. J.Nutri. 129(4):804–813.
  • Naderi, G. A., Asgary, S., Sarraf-Zadegan, N. and Shirvany, H. (2003). Anti-oxidant effect of flavonoids on the susceptibility of LDL oxidation. Mol. Cell. Biochem. 246(1–2):193–196.
  • Nakaizumi, A., Baba, M., Uehara, H., Iishi, H. and Tatsuta, M. (1997). d-Limonene inhibits N-nitrosobis (2-oxopropyl) amine induced hamster pancreatic carcinogenesis. Cancer Lett. 117(1):99–103.
  • Nielsen, J. and Oliver, S. (2005). The next wave in metabolome analysis. Trends Biotechnol. 23(11):544–546.
  • Niggeweg, R., Michael, A. J. and Martin, C. (2004). Engineering plants with increased levels of the antioxidant chlorogenic acid. Nat. Biotechnol. 22(6):746–754.
  • Nordström, A., O'Maille, G., Qin, C. and Siuzdak, G. (2006). Nonlinear data alignment for UPLC-MS and HPLC-MS based metabolomics: Quantitative analysis of endogenous and exogenous metabolites in human serum. Anal. Chem. 78(10):3289–3295.
  • Ogo, Y., Ozawa, K., Ishimaru, T., Murayama, T. and Takaiwa, F. (2013). Transgenic rice seed synthesizing diverse flavonoids at high levels: A new platform for flavonoid production with associated health benefits. Plant Biotechnol. J. 11(6):734–746.
  • Okazaki, Y. and Saito, K. (2012). Recent advances of metabolomics in plant biotechnology. Plant Biotechnol. Rep. 6(1):1–15.
  • Oksman-Caldentey, K.-M. and Saito, K. (2005). Integrating genomics and metabolomics for engineering plant metabolic pathways. Curr. Opin. Biotechnol. 16(2):174–179.
  • Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G. and Goldberg, D. M. (1995). The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease. Clin. Chim. Acta 235(2):207–219.
  • Pan, A., Yu, D., Demark-Wahnefried, W., Franco, O. H. and Lin, X. (2009). Meta-analysis of the effects of flaxseed interventions on blood lipids. Am. J. Clin. Nutr. 90(2):288–97.
  • Pandey, K. B. and Rizvi, S. I. (2009). Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell Longev. 2(5):270–278.
  • Park, N. I., Xu, H., Li, X., Kim, Y. S., Lee, M. Y. and Park, S. U. (2012). Overexpression of phenylalanine ammonia-lyase improves flavones production in transgenic hairy root cultures of Scutellaria baicalensis. Process Biochem. 47(12):2575–2580.
  • Pasikanti, K. K., Ho, P. and Chan, E. (2008). Gas chromatography/mass spectrometry in metabolic profiling of biological fluids. J. Chromatogr. B 871(2):202–211.
  • Patti, G. J., Yanes, O. and Siuzdak, G. (2012). Innovation: Metabolomics: The apogee of the omics trilogy. Nat. Rev. Mol. Cell Biol. 13(4):263–269.
  • Perez-Fons, L., Wells, T., Corol, D. I., Ward, J. L., Gerrish, C., Beale, M. H., Seymour, G. B., Bramley, P. M. and Fraser, P. D. (2014). A genome-wide metabolomic resource for tomato fruit from Solanum pennellii. Sci. Rep. 4.
  • Peterman, S. M., Duczak Jr, N., Kalgutkar, A. S., Lame, M. E. and Soglia, J. R. (2006). Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: Examination of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements. J. Am. Soc. Mass Spectrom. 17(3):363–375.
  • Peterson, J., Dwyer, J., Adlercreutz, H., Scalbert, A., Jacques, P. and McCullough, M. L. (2010). Dietary lignans: Physiology and potential for cardiovascular disease risk reduction. Nutrition Rev. 68(10):571–603.
  • Pool-Zobel, B., Bub, A., Schröder, N. and Rechkemmer, G. (1999). Anthocyanins are potent antioxidants in model systems but do not reduce endogenous oxidative DNA damage in human colon cells. Eur. J. Nutr. 38(5):227–234.
  • Prakash, D. and Sharma, G. (2014). Phytochemicals of Nutraceutical Importance, CABI, http://www.cabi.org/bookshop/book/9781780643632
  • Prakash, D., Upadhyay, G., Singh, B. N. and Singh, H. (2007). Antioxidant and free radical-scavenging activities of seeds and agri-wastes of some varieties of soybean (Glycine max). Food Chem. 104(2):783–790.
  • Pushpa, D., Yogendra, K. N., Gunnaiah, R., Kushalappa, A. C. and Murphy, A. (2014). Identification of late blight resistance-related metabolites and genes in potato through nontargeted metabolomics. Plant Mol. Biol. Rep. 32(2):584–595.
  • Puupponen-Pimiä, R., Nohynek, L., Meier, C., Kähkönen, M., Heinonen, M., Hopia, A. and Oksman-Caldentey, K. M. (2001). Antimicrobial properties of phenolic compounds from berries. J. Appl. Microbiol. 90(4):494–507.
  • Rai, R. K., Azim, A., Sinha, N., Sahoo, J. N., Singh, C., Ahmed, A., Saigal, S., Baronia, A. K., Gupta, D. and Gurjar, M. (2013). Metabolic profiling in human lung injuries by high-resolution nuclear magnetic resonance spectroscopy of bronchoalveolar lavage fluid (BALF). Metabolomics 9(3):667–676.
  • Rakshit, S., Mandal, L., Pal, B. C., Bagchi, J., Biswas, N., Chaudhuri, J., Chowdhury, A. A., Manna, A., Chaudhuri, U. and Konar, A. (2010). Involvement of ROS in chlorogenic acid-induced apoptosis of Bcr-Abl+ CML cells. Biochem. Pharmacol. 80(11):1662–1675.
  • Ratnoff, O. D. and Crum, J. D. (1964). Activation of Hageman factor by solutions of ellagic acid. J. Lab. Clin. Med. 63(3):359–377.
  • Ren, W., Qiao, Z., Wang, H., Zhu, L. and Zhang, L. (2003). Flavonoids: Promising anticancer agents. Med. Res. Rev. 23(4):519–534.
  • Roberfroid, M. B. (1999). Concepts in functional foods: The case of inulin and oligofructose. J. Nutri. 129(7 Suppl):1398S–1401S.
  • Romero-Perez, A. I., Ibern-Gomez, M., Lamuela-Raventos, R. M. and de la Torre-Boronat, M. C. (1999). Piceid, the major resveratrol derivative in grape juices. J. Agric. Food Chem. 47(4):1533–1536.
  • Romero-Perez, A. I., Lamuela-Raventos, R. M., Buxaderas, S. and de la Torre-Boronat, M. C. (1996b). Resveratrol and piceid as varietal markers of white wines. J. Agric. Food Chem. 44:1975–1978.
  • Romero-Perez, A. I., Lamuela-Raventos, R. M., Waterhouse, A. L. and de la Torre-Boronat, M. C. (1996a). Levels of cis- and trans resveratrol and piceid isomers in rose and white Vitis vinifera wines. J. Agric. Food Chem. 44:2124–2128.
  • Ross, A. B., Kamal-Eldin, A. and Åman, P. (2004). Dietary alkylresorcinols: Absorption, bioactivities, and possible use as biomarkers of whole-grain wheat–and rye–rich Foods. Nutr. Rev. 62(3):81–95.
  • Salunkhe, D., Jadhav, S., Kadam, S., Chavan, J. and Luh, B. (1983). Chemical, biochemical, and biological significance of polyphenols in cereals and legumes. Crit. Rev. Food Sci. Nutr. 17(3):277–305.
  • Sawai, S. and Saito, K. (2011). Triterpenoid biosynthesis and engineering in plants. Front. Plant. Sci. 2(25):1–8.
  • Saxena, A. and Cramer, C. S. (2013). Metabolomics: A potential tool for breeding nutraceutical vegetables. Adv. Crop Sci. Tech. 1(106):2.
  • Scalbert, A. and Williamson, G. (2000). Dietary intake and bioavailability of polyphenols. J. Nutri. 130(8):2073S–2085S.
  • Scalbert, A., Manach, C., Morand, C., Rémésy, C. and Jiménez, L. (2005). Dietary polyphenols and the prevention of diseases. Crit. Rev. Food Sci. Nutr. 45(4):287–306.
  • Schauer, N. and Fernie, A. R. (2006). Plant metabolomics: Towards biological function and mechanism. Trends Plant Sci. 11(10):508–516.
  • Schauer, N., Semel, Y., Roessner, U., Gur, A., Balbo, I., Carrari, F., Pleban, T., Perez-Melis, A., Bruedigam, C., Kopka, J. and Willmitzer, L. (2006). Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement. Nature Biotechnol. 24(4):447–454.
  • Seguin, P., Tremblay, G., Pageau, D., Liu, W. and Turcotte, P. (2011). Soybean lutein concentration: Impact of crop management and genotypes. Crop Sci. 51(3):1151–1160.
  • Serhan, C. N., Chiang, N. and Van Dyke, T. E. (2008). Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nat. Rev. Immunol. 8(5):349–361.
  • Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G. and Moussignac, R.-L. (2002). Resolvins a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J. Exp. Med. 196(8):1025–1037.
  • Shahidi, F. and Naczk, M. (1995). Food Phenolics, Sources, Chemistry, Effects, Applications. Technomic Publishing Co Inc, Lancaster, PA.
  • Shi, M., Luo, X., Ju, G., Yu, X., Hao, X., Huang, Q., Xiao, J., Cui, L. and Kai, G. (2014). Increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in Salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl CoA reductase and 1-deoxy-D-xylulose 5-phosphate reductoisomerase. Funct. Integr. Genomics 14(3):603–615.
  • Shi, Q., Hui, S., Zhang, A.-H., Hong-Ying, X., Guang-Li, Y., Ying, H. and Xi-Jun, W. (2014). Natural alkaloids: Basic aspects, biological roles, and future perspectives. Chin. J. Nat. Med. 12(6):401–406.
  • Shulaev, V. (2006). Metabolomics technology and bioinformatics. Brief. Bioinform. 7(2):128–139.
  • Sigler, K. and Ruch, R. J. (1993). Enhancement of gap junctional intercellular communication in tumor promoter-treated cells by components of green tea. Cancer Lett. 69(1):15–19.
  • Singh, M., Pal, M. and Sharma, R. (1999). Biological activity of the labdane diterpenes. Planta Med. 65(01):002–008.
  • Sinha, K., Chaudhary, G. and Gupta, Y. K. (2002). Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci. 71(6):655–665.
  • Smeds, A. I., Willfor, S. M., Pietarinen, S. P., Peltonen-Sainio, P. and Reunanen, M. H. (2007). Occurrence of “mammalian” lignans in plant and water sources. Planta 226(3):639–46.
  • Smith, C. A., O'Maille, G., Want, E. J., Qin, C., Trauger, S. A., Brandon, T. R., Custodio, D. E., Abagyan, R. and Siuzdak, G. (2005). METLIN: a metabolite mass spectral database. Ther. Drug Monit. 27:747–751.
  • Sova, M. (2012). Antioxidant and antimicrobial activities of cinnamic acid derivatives. Mini Rev. Med.Chem. 12(8):749–767.
  • Srinivasan, M., Sudheer, A. R. and Menon, V. P. (2007). Ferulic acid: Therapeutic potential through its antioxidant property. J. Clin. Biochem. Nutr. 40(2):92–100.
  • Stewart, D., McDougall, G. J., Sungurtas, J., Verrall, S., Graham, J. and Martinussen, I. (2007). Metabolomic approach to identifying bioactive compounds in berries: Advances toward fruit nutritional enhancement. Mol. Nutr. Food Res. 51(6):645–651.
  • Suttipanta, N., Pattanaik, S., Kulshrestha, M., Patra, B., Singh, S. K. and Yuan, L. (2011). The transcription factor CrWRKY1 positively regulates the terpenoid indole alkaloid biosynthesis in Catharanthus roseus. Plant Physiol. 157(4):2081–2093.
  • Telang, N. T., Katdare, M., Bradlow, H. L., Osborne, M. P. and Fishman, J. (1997). Inhibition of proliferation and modulation of estradiol metabolism: Novel mechanisms for breast cancer prevention by the phytochemical indole-3-carbinol. Proc. Soc. Exp. Biol. Med. 216(2):246–252.
  • Tian, J., Peng, Z., Zhang, J., Song, T., Wan, H., Zhang, M. and Yao, Y. (2015). McMYB10 regulates coloration via activating McF3′ H and later structural genes in ever‐red leaf crabapple. Plant Biotechnol. J. 13(7):948–961.
  • Tohge, T. and Fernie, A. R. (2010). Combining genetic diversity, informatics and metabolomics to facilitate annotation of plant gene function. Nat. Protoc. 5(6):1210–1227.
  • Tozawa, Y., Hasegawa, H., Terakawa, T. and Wakasa, K. (2001). Characterization of rice anthranilate synthase α-subunit genes OASA1 and OASA2. tryptophan accumulation in transgenic rice expressing a feedback-insensitive mutant of OASA1. Plant Physiol. 126(4):1493–1506.
  • Traka, M. and Mithen, R. (2009). Glucosinolates, isothiocyanates and human health. Phytochem. Rev. 8(1):269–282.
  • Trujillo, E., Davis, C. and Milner, J. (2006). Nutrigenomics, proteomics, metabolomics, and the practice of dietetics. J. Am. Diet. Assoc. 106(3):403–413.
  • Tuan, P. A., Bai, S., Yaegaki, H., Tamura, T., Hihara, S., Moriguchi, T. and Oda, K. (2015). The crucial role of PpMYB10. 1 in anthocyanin accumulation in peach and relationships between its allelic type and skin color phenotype. BMC Plant Biol. 15(1):1.
  • Voytas, D. F. and Gao, C. (2014). Precision genome engineering and agriculture: Opportunities and regulatory challenges. PLoS Biol. 12(6):e1001877.
  • Wakasa, K., Hasegawa, H., Nemoto, H., Matsuda, F., Miyazawa, H., Tozawa, Y., Morino, K., Komatsu, A., Yamada, T. and Terakawa, T. (2006). High-level tryptophan accumulation in seeds of transgenic rice and its limited effects on agronomic traits and seed metabolite profile. J. Exp. Bot. 57(12):3069–3078.
  • Wang, C., Zeng, J., Li, Y., Hu, W., Chen, L., Miao, Y., Deng, P., Yuan, C., Ma, C. and Chen, X. (2014). Enrichment of provitamin A content in wheat (Triticum aestivum L.) by introduction of the bacterial carotenoid biosynthetic genes CrtB and CrtI. J. Exp. Bot. 65(9):2545–2556.
  • Wang, H. H., Isaacs, F. J., Carr, P. A., Sun, Z. Z., Xu, G., Forest, C. R. and Church, G. M. (2009). Programming cells by multiplex genome engineering and accelerated evolution. Nature 460(7257):894–898.
  • Watson, R. R. and Preedy, V. R. (2010). Bioactive Foods in Promoting Health: Probiotics and Prebiotics, Academic Press, USA.
  • Wells, D. B., Humphrey, H. D. and Coll, J. J. (1942). The relation of tannic acid to the liver necrosis occurring in burns. N. Engl. J. Med. 226(16):629–636.
  • Woodruff, L. B. and Gill, R. T. (2011). Engineering genomes in multiplex. Curr. Opin. Biotechnol. 22(4):576–583.
  • Xu, H., Kim, S., Sorek, H., Lee, Y., Jeong, D., Kim, J., Oh, E. J., Yun, E. J., Wemmer, D. E. and Kim, K. H. (2016). PHO13 deletion-induced transcriptional activation prevents sedoheptulose accumulation during xylose metabolism in engineered Saccharomyces cerevisiae. Metab. Eng. 34:88–96.
  • Yao, L. H., Jiang, Y., Shi, J., Tomas-Barberan, F., Datta, N., Singanusong, R. and Chen, S. (2004). Flavonoids in food and their health benefits. Plant Foods Hum. Nutr. 59(3):113–122.
  • Yeum, K.-J., Taylor, A., Tang, G. and Russell, R. M. (1995). Measurement of carotenoids, retinoids, and tocopherols in human lenses. Invest. Ophthalmol. Vis. Sci. 36(13):2756–2761.
  • Yogendra, K. N., Kumar, A., Sarkar, K., Li, Y., Pushpa, D., Mosa, K. A., Duggavathi, R. and Kushalappa, A. C. (2015). Transcription factor StWRKY1 regulates phenylpropanoid metabolites conferring late blight resistance in potato. J. Exp. Bot. 66(22):7377–7389.
  • Yogendra, K., Pushpa, D., Mosa, K., Kushalappa, A., Murphy, A. and Mosquera, T. (2014). Quantitative resistance in potato leaves to late blight associated with induced hydroxycinnamic acid amides. Funct. Integr. Genomics 14(2):285–298. doi: 10.1007/s10142-013-0358-8
  • Yu, W., Simmons-Menchaca, M., Gapor, A., Sanders, B. G. and Kline, K. (1999). Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr. Cancer 33(1):26–32.
  • Zalatan, J. G., Lee, M. E., Almeida, R., Gilbert, L. A., Whitehead, E. H., La Russa, M., Tsai, J. C., Weissman, J. S., Dueber, J. E. and Qi, L. S. (2015). Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell 160(1):339–350.
  • Zhang, F., Lu, X., Lv, Z., Zhang, L., Zhu, M., Jiang, W., Wang, G., Sun, X. and Tang, K. (2013b). Overexpression of the Artemisia orthologue of ABA receptor, AaPYL9, enhances ABA sensitivity and improves artemisinin content in Artemisia annua L. PLoS One 8(2):e56697.
  • Zhang, R., Zhang, B. L., Li, G. C., Xie, T., Hu, T. and Luo, Z. Y. (2015). Enhancement of ginsenoside Rg1 in Panax ginseng hairy root by overexpressing the α-l-rhamnosidase gene from Bifidobacterium breve. Biotechnol. Lett. 37(10):2091–2096.
  • Zhang, S., Ma, P., Yang, D., Li, W., Liang, Z., Liu, Y. and Liu, F. (2013a). Cloning and characterization of a putative R2R3 MYB transcriptional repressor of the rosmarinic acid biosynthetic pathway from Salvia miltiorrhiza. PLoS One 8(9):e73259.
  • Zhang, S., Tang, G., Russell, R. M., Mayzel, K. A., Stampfer, M. J., Willett, W. C. and Hunter, D. J. (1997). Measurement of retinoids and carotenoids in breast adipose tissue and a comparison of concentrations in breast cancer cases and control subjects. Am. J. Clin. Nutr. 66(3):626–632.
  • Zheng, P., Allen, W. B., Roesler, K., Williams, M. E., Zhang, S., Li, J., Glassman, K., Ranch, J., Nubel, D. and Solawetz, W. (2008). A phenylalanine in DGAT is a key determinant of oil content and composition in maize. Nat. Genet. 40(3):367–372.
  • Ziegler, R. G., Mayne, S. T. and Swanson, C. A. (1996). Nutrition and lung cancer. Cancer Causes Control 7(1):157–177.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.