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The future of nutrition: Nutrigenomics and nutrigenetics in obesity and cardiovascular diseases

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  • Alsaleh, A., O'Dell, S. D., Frost, G. S., Griffin, B. A., Lovegrove, J. A., Jebb, S. A., Sanders, T. A. and RISCK Study investigators. (2011). Interaction of PPARγ Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk. J. Lipid. Res. 52:2298–2303.
  • Alsaleh, A., Sanders, T. A. and O'Dell, S. D. (2012). Effect of interaction between PPARG, PPARA and ADIPOQ gene variants and dietary fatty acids on plasma lipid profile and adiponectin concentration in a large intervention study. Proc. Nutr. Soc. 71:141–153.
  • Antonarakis, S. E., Oettgen, P., Chakravarti, A., Halloran, S. L., Hudson, R. R., Feisee, L. and Karathanasis, S. K. (1988). DNA polymorphism haplotypes of the human APOlipoprotein APOA1-APOC3-APOA4 gene cluster. Hum. Genet. 80:265–273.
  • Apalasamy, Y. D., Moy, F. M., Rampal, S., Bulgiba, A. and Mohamed, Z. (2014). Genetic associations of the INSIG2 rs7566605 polymorphism with obesity-related metabolic traits in Malaysian Malays. Genet Mol. Res. 13:4904–4910.
  • Aouizerat, B. E., Kulkarni, M., Heilbron, D., Drown, D., Raskin, S., Pullinger, C. R., Malloy, M. J. and Kane, J. P. (2003). Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids. J. Lipid. Res. 44:1167–1173.
  • Attila, G., Acartürk, E., Eskandari, G., Akpinar, O., Tuli, A., KanadaşI, M. and Kayrin, L. (2001). Effects of apolipoprotein E genotypes and other risk factors on the development of coronary artery disease in Southern Turkey. Clin. Chim. Acta. 312:191–196.
  • Bewick, G. A., Gardiner, J. V., Dhillo, W. S., Kent, A. S., White, N. E., Webster, Z., Ghatei, M. A. and Bloom, S. R. (2005). Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype. FASEB J. 19:1680–1682.
  • Chen, Y. Y., Wang, B. N. and Yu, X. P. (2016). Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease. Genet. Mol. Res. 15.
  • Corella, D. and Ordovás, J. M. (2005). Integration of environment and disease into ‘omics’ analysis. Curr. Opin. Mol. Ther. 7:569–576.
  • Corella, D. and Ordovas, J. M. (2009). Nutrigenomics in cardiovascular medicine. Circ. Cardiovasc. Genet. 2:637–651.
  • Corella, D., Peloso, G., Arnett, D. K., Demissie, S., Cupples, L. A., Tucker, K., Lai, C. Q., Parnell, L. D., Coltell, O., Lee, Y. C. and Ordovás, J. M. (2009). APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations. Arch. Intern. Med. 169:1897–1906.
  • de Luis, D. A., Aller, R., Conde, R., Izaola, O., de la Fuente, B., González-Sagrado, M., Primo, D. and Ruiz-Mambrilla, M. (2012). Relation of the rs9939609 gene variant in FTO with cardiovascular risk factor and serum adipokine levels in morbid obese patients. Nutr. Hosp. 27:1184–1189.
  • de Luis, D. A., Izaola, O., Primo, D. and Pacheco, D. (2016). Effect of the rs10767664 variant of the brain-derived neurotrophic factor gene on weight change and cardiovascular risk factors in morbidly obese patients after biliopancreatic diversion surgery. J. Nutrigenet. Nutrigenomics. 9:116–122.
  • Domínguez-Reyes, T., Astudillo-López, C. C., Salgado-Goytia, L., Muñoz-Valle, J. F., Salgado-Bernabé, A. B., Guzmán-Guzmán, I. P., Castro-Alarcón, N., Moreno-Godínez, M. E. and Parra-Rojas, I. (2015). Interaction of dietary fat intake with APOA2, APOA5 and LEPR polymorphisms and its relationship with obesity and dyslipidemia in young subjects. Lipids Health Dis. 14:106–116.
  • Duicu, C., Mărginean, C. O., Voidăzan, S., Tripon, F. and Bănescu, C. (2016). FTO rs 9939609 SNP is associated with adiponectin and leptin levels and the risk of obesity in a cohort of Romanian children population. Medicine (Baltimore) 2016; 95:e3709.
  • Eaton, D. L., Bammler, T. K. and Kelly, E. J. (2001). Interindividual differences in response to chemoprotection against aflatoxin-induced hepatocarcinogenesis: implications for human biotransformation enzyme polymorphisms. Adv. Exp. Med. Biol. 500:559–576.
  • Egert, S., Boesch-Saadatmandi, C., Wolffram, S., Rimbach, G. and Müller, M. J. (2010). Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. J. Nutr. 140:278–284.
  • Endo, K., Yanagi, H., Araki, J., Hirano, C., Yamakawa-Kobayashi, K. and Tomura, S. (2002). Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren. Hum. Genet. 111:570–572.
  • Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M. I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., Lamuela-Raventos, R. M., Serra-Majem, L., Pintó, X., Basora, J., Muñoz, M. A., Sorlí, J. V., Martínez, J. A., Martínez-González, M. A. and PREDIMED Study Investigators. (2013). Primary prevention of cardiovascular disease with a mediterranean diet. N. Engl. J. Med. 368:1279–1290.
  • Fekih-Mrissa, N., Mrad, M., Ibrahim, H., Akremi, I., Sayeh, A., Jaidane, A., Ouertani, H., Zidi, B. and Gritli, N. (2017). Methylenetetrahydrofolate reductase (MTHFR) (C677T and A1298C) polymorphisms and vascular complications in patients with type 2 diabetes. Can. J. Diabetes. 41:366–371.
  • Ferguson, J. F., Allayee, H., Gerszten, R. E., Ideraabdullah, F., Kris-Etherton, P. M., Ordovás, J. M., Rimm, E. B., Wang, T. J., Bennett, B. J. and American Heart Association Council on Functional Genomics and Translational Biology, Council on Epidemiology and Prevention, and Stroke Council. (2016). Nutrigenomics, the microbiome, and gene-environment interactions: New directions in cardiovascular disease research, prevention, and treatment: a scientific statement from the American heart association. Circ. Cardiovasc. Genet. 9:291–313.
  • Friedman, J. M. (2004). Modern science versus the stigma of obesity. Nat. Med. 10:563–569.
  • Fornage, M., Papanicolaou, G., Lewis, C. E., Boerwinkle, E. and Siscovick, D. S. (2010). Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age. Metabolism. 59:1084–1091.
  • García-Calzón, S., Martínez-González, M. A., Razquin, C., Corella, D., Salas-Salvadó, J., Martínez, J. A., Zalba, G. and Marti. A. (2015). Pro12Ala polymorphism of the PPARγ2 gene interacts with a mediterranean diet to prevent telomere shortening in the PREDIMED-NAVARRA randomized trial. Circ. Cardiovasc. Genet. 8:91–99.
  • Gearing, K. L., Göttlicher, M., Widmark, E., Banner, C. D., Tollet, P., Strömstedt, M., Rafter, J. J., Berge, R. K. and Gustafsson, J. A. (1994). Fatty acid activation of the peroxisome proliferator activated receptor, a member of the nuclear receptor gene superfamily. J. Nutr. 1994; 124:1284–1288.
  • Geller, F., Reichwald, K., Dempfle, A., Illig, T., Vollmert, C., Herpertz, S., Siffert, W., Platzer, M., Hess, C., Gudermann, T., Biebermann, H., Wichmann, H. E., Schäfer, H., Hinney, A. and Hebebrand, J. (2004). Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am. J. Hum. Genet. 74:572–581.
  • Ghiselli, G., Gregg, R. E., Zech, L. A., Schaefer, E. J. and Brewer, H. B. Jr. (1982). Phenotype study of Apolipoprotein E isoforms in hyperlipoproteinemic patients. Lancet. 2:405–407.
  • Goni, L., Cuervo, M., Milagro, F. I. and Martínez, J. A. (2016). Future perspectives of personalized weight loss interventions based on nutrigenetic, epigenetic, and metagenomic data. J. Nutr. 146(Suppl):905S–12S.
  • Gotoda, T., Scott, J. and Aitman, T. J. (1997). Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin. Diabetologia. 40:976–979.
  • Guclu-Geyik, F., Onat, A., Coban, N., Komurcu-Bayrak, E., Sansoy, V., Can, G. and Erginel-Unaltuna, N. (2012). Minor allele of the APOA4 gene T347S polymorphism predisposes to obesity in postmenopausal Turkish women. Mol. Biol. Rep. 39:10907–10914.
  • Heid, I. M., Vollmert, C., Kronenberg, F., Huth, C., Ankerst, D. P., Luchner, A., Hinney, A., Brönner, G., Wichmann, H. E., Illig, T., Döring, A. and Hebebrand, J. (2008). Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA study. Obesity. 16:369–376.
  • Heid, I. M., Huth, C., Loos, R. J., Kronenberg, F., Adamkova, V., Anand, S. S., Ardlie, K., Biebermann, H., Bjerregaard, P., Boeing, H., Bouchard, C., Ciullo, M., Cooper, J. A., Corella, D., Dina, C., Engert, J. C., Fisher, E., Francès, F., Froguel, P., Hebebrand, J., Hegele, R. A., Hinney, A., Hoehe, M. R., Hu, F. B., Hubacek, J. A., Humphries, S. E., Hunt, S. C., Illig, T., Järvelin, M. R., Kaakinen, M., Kollerits, B., Krude, H., Kumar, J., Lange, L. A., Langer, B., Li, S., Luchner, A., Lyon, H. N., Meyre, D., Mohlke, K. L., Mooser, V., Nebel, A., Nguyen, T. T., Paulweber, B., Perusse, L., Qi, L., Rankinen, T., Rosskopf, D., Schreiber, S., Sengupta, S., Sorice, R., Suk, A., Thorleifsson, G., Thorsteinsdottir, U., Völzke, H., Vimaleswaran, K. S., Wareham, N. J., Waterworth, D., Yusuf, S., Lindgren, C., McCarthy, M. I., Lange, C., Hirschhorn, J. N., Laird, N. and Wichmann, H. E. (2009). Meta-analysis of the INSIG2 association with obesity including 74 345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet. 5:e1000694.
  • Isaacs, A., Sayed-Tabatabaei, F. A., Njajou, O. T., Witteman, J. C. and van Duijn, C. M. (2004). The -514 C>T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis. J. Clin. Endocrinol. Metab. 89:3858–3863.
  • Juma, S., Imrhan, V., Vijayagopal, P. and Prasad, C. (2014). Prescribing personalized nutrition for cardiovascular health: are we ready? J. Nutrigenet. Nutrigenomics. 7:153–160.
  • Kaulfers, A. M., Deka, R., Dolan, L. and Martin, L. J. (2015). Association of INSIG2 polymorphism with overweight and LDL in children. PLoS One. 10:e0116340.
  • Knoblauch, H., Bauerfeind, A., Toliat, M. R., Becker, C., Luganskaja, T., Günther, U. P., Rohde, K., Schuster, H., Junghans, C., Luft, F. C., Nürnberg, P. and Reich, J. G. (2004). Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol. Hum. Mol. Genet. 13:993–1004.
  • Kolovou, G. D., Kolovou, V., Papadopoulou, A. and Watts, G. F. (2016). MTP gene variants and response to lomitapide in patients with homozygous familial hypercholesterolemia. J. Atheroscler. Thromb. 23:878–883.
  • Kussmann, M. and Van Bladeren, P. J. (2011). The extended nutrigenomics—understanding the interplay between the genomes of food, gut microbes, and human host. Front Genet. 2:1–13.
  • Latruffe, N. and Vamecq, J. (1997). Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie. 79:81–94.
  • Lehnert, T., Streltchenia, P., Konnopka, A., Riedel-Heller, S. G. and König, H. H. (2015). Health burden and costs of obesity and overweight in Germany: an update. Eur. J. Health Econ. 16:957–967.
  • Li, W. X., Liao, P., Hu, C. Y., Cheng, F., Zhang, T., Sun, Y. Y., Tang, L., Wang, M. M., Liu, K. S., Liu, D. and Liu, F. (2017). Interactions of methylenetetrahydrofolate reductase gene polymorphisms, folate, and homocysteine on blood pressure in a Chinese hypertensive population. Clin. Lab. 63:817–825.
  • Liu, G., Zhu, H., Dong, Y., Podolsky, R. H., Treiber, F. A. and Snieder, H. (2011). Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth. Eur. J. Epidemiol. 26:463–473.
  • Loos, R. J. and Bouchard, C. (2003). Obesity-is it a genetic disorder? J. Intern. Med. 254:401–425.
  • Mahley, R. W., Huang, Y. and Rall. S. C. Jr. (1999). Pathogenesis of type III Hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries and paradoxes. J. Lipid Res. 40:1933–1949.
  • Malzahn, D., Müller-Nurasyid, M., Heid, I. M., Wichmann, H. E., Bickeböller, H. and KORA study group. (2014). Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R. Eur. J. Hum. Genet. 22:1217–1224.
  • Martínez, J. A. (2014). Perspectives on personalized nutrition for obesity. J. Nutrigenet. Nutrigenomics. 7:I–III.
  • Masud, R. and Baqai, H. Z. (2017). The communal relation of MTHFR, MTR, ACE gene polymorphisms, and hyperhomocysteinemia as conceivable risk of coronary artery disease. Appl. Physiol. Nutr. Metab. [ Epub ahead of print].
  • Masud, R. and Qureshi, I. Z. (2011). Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease. Mol. Cell. Biochem. 355:289–297.
  • Miae, D. and Yangha, K. (2015). Obesity: Interactions of genome and nutrients intake. Prev. Nutr. Food Sci. 20:1–7.
  • Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J. P., Fullerton, H. J., Howard, V. J., Huffman, M. D., Isasi, C. R., Jiménez, M. C., Judd, S. E., Kissela, B. M., Lichtman, J. H., Lisabeth, L. D., Liu, S., Mackey, R. H., Magid, D. J., McGuire, D. K., Mohler, E. R. 3rd, Moy, C. S., Muntner, P., Mussolino, M. E., Nasir, K., Neumar, R. W., Nichol, G., Palaniappan, L., Pandey, D. K., Reeves, M. J., Rodriguez, C. J., Rosamond, W., Sorlie, P. D., Stein, J., Towfighi, A., Turan, T. N., Virani, S. S., Woo, D., Yeh, R. W., Turner, M. B., American Heart Association Statistics Committee and Stroke Statistics Subcommittee. (2016). Heart disease and stroke statistics-2016 update: a report from the American heart association. Circulation. 133:e38–360.
  • Mutch, D. M., Wahli, W. and Williamson, G. (2005). Nutrigenomics and nutrigenetics: the emerging faces of nutrition. Faseb. J. 19:1602–1616.
  • Narayanaswami, V. and Dwoskin, L. P. (2016). Obesity: current and potential pharmacotherapeutics and targets. Pharmacol. Ther. 170:116–147. [ Epub ahead of print].
  • Nishi, S., Kendall, C. W., Gascoyne, A. M., Bazinet, R. P., Bashyam, B., Lapsley, K. G., Augustin, L. S., Sievenpiper, J. L. and Jenkins, D. J. (2014). Effect of almond consumption on the serum fatty acid profile: a dose-response study. Br. J. Nutr. 112:1137–1146.
  • Ollmann, M. M., Wilson, B. D., Yang, Y. K., Kerns, J. A., Chen, Y., Gantz, I. and Barsh, G. S. (1997). Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science. 278:135–138.
  • Ordovas, J. M., Corella, D., Cupples, L. A., Demissie, S., Kelleher, A., Coltell, O., Wilson, P. W., Schaefer, E. J. and Tucker, K. (2002). Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study. Am. J. Clin. Nutr. 75:38–46.
  • Ordovás, J. M. and Corella, D. (2004). Nutritional genomics. Annu. Rev. Genomics Hum. Genet. 5:71–118.
  • Posadas-Sánchez, R., Ocampo-Arcos, W. A., López-Uribe, Á. R., Posadas-Romero, C., Villarreal-Molina, T., León, E. Á., Pérez-Hernández, N., Rodríguez-Pérez, J. M., Cardoso-Saldaña, G., Medina-Urrutia, A. and Vargas-Alarcón, G. (2015). Hepatic lipase (LIPC) C-514T gene polymorphism is associated with cardiometabolic parameters and cardiovascular risk factors but not with fatty liver in Mexican population. Exp. Mol. Pathol. 98:93–98.
  • Prentice, A. (1995). Le symposium Lavoisier. Proc. Nutr. Soc. 54:1–8.
  • Qi, Q., Kilpeläinen, T. O., Downer, M. K., Tanaka, T., Smith, C. E., Sluijs, I., Sonestedt, E., Chu, A. Y., Renström, F., Lin, X., Ängquist, L. H., Huang, J., Liu, Z., Li, Y., Asif Ali, M., Xu, M., Ahluwalia, T. S., Boer, J. M., Chen, P., Daimon, M., Eriksson, J., Perola, M., Friedlander, Y., Gao, Y. T., Heppe, D. H., Holloway, J. W., Houston, D. K., Kanoni, S., Kim, Y. M., Laaksonen, M. A., Jääskeläinen, T., Lee, N. R., Lehtimäki, T., Lemaitre, R. N., Lu, W., Luben, R. N., Manichaikul, A., Männistö, S., Marques-Vidal, P., Monda, K. L., Ngwa, J. S., Perusse, L., van Rooij, F. J., Xiang, Y. B., Wen, W., Wojczynski, M. K., Zhu, J., Borecki, I. B., Bouchard, C., Cai, Q., Cooper, C., Dedoussis, G. V., Deloukas, P., Ferrucci, L., Forouhi, N. G., Hansen, T., Christiansen, L., Hofman, A., Johansson, I., Jørgensen, T., Karasawa, S., Khaw, K. T., Kim, M. K., Kristiansson, K., Li, H., Lin, X., Liu, Y., Lohman, K. K., Long, J., Mikkilä, V., Mozaffarian, D., North, K., Pedersen, O., Raitakari, O., Rissanen, H., Tuomilehto, J., van der Schouw, Y. T., Uitterlinden, A. G., Zillikens, M. C., Franco, O. H., Shyong Tai, E., Ou Shu, X., Siscovick, D. S., Toft, U., Verschuren, W. M., Vollenweider, P., Wareham, N. J., Witteman, J. C., Zheng, W., Ridker, P. M., Kang, J. H., Liang, L., Jensen, M. K., Curhan, G. C., Pasquale, L. R., Hunter, D. J., Mohlke, K. L., Uusitupa, M., Cupples, L. A., Rankinen, T., Orho-Melander, M., Wang, T., Chasman, D. I., Franks, P. W., Sørensen, T. I., Hu, F. B., Loos, R. J., Nettleton, J. A. and Qi, L. (2014). FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. Hum. Mol. Genet. 23:6961–6972.
  • Raina, J. K., Sharma, M., Panjaliya, R. K., Bhagat, M., Sharma, R., Bakaya, A. and Kumar, P. (2016). Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms and associated risk of cardiovascular diseases: a study from Jammu region. Indian Heart J. 68:421–430.
  • Razquin, C., Alfredo-Martinez, J., Martinez-Gonzalez, M. A., Corella, D., Santos, J. M. and Marti, A. (2009). The Mediterranean diet protects against waist circumference enlargement in 12Ala carriers for the PPARgamma gene: 2 years' follow-up of 774 subjects at high cardiovascular risk. Br. J. Nutr. 102:672–679.
  • Sadeghirad, B., Duhaney, T., Motaghipisheh, S., Campbell, N. R. and Johnston, B. C. (2016). Influence of unhealthy food and beverage marketing on children's dietary intake and preference: a systematic review and meta-analysis of randomized trials. Obes. Rev. 17:945–959.
  • Santos, M. J. (2004). The genetic council's bioethic aspects in the human genome project's era. Acta Bioethica. 10:191–200.
  • Schwartz, M. W., Woods, S. C., Porte, D., Jr., Seeley, R. J. and Baskin, D. G. (2000). Central nervous system control of food intake. Nature. 404:661–671.
  • Scuteri, A., Sanna, S., Chen, W. M., Uda, M., Albai, G., Strait, J., Najjar, S., Nagaraja, R., Orrú, M., Usala, G., Dei, M., Lai, S., Maschio, A., Busonero, F., Mulas, A., Ehret, G. B., Fink, A. A., Weder, A. B., Cooper, R. S., Galan, P., Chakravarti, A., Schlessinger, D., Cao, A., Lakatta, E. and Abecasis, G. R. (2007). Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 3:e115.
  • Singh, P. P., Singh, M. and Mastana, S. S. (2006). APOE distribution in world populations with new data from India and the UK. Ann. Hum. Biol. 33:279–308.
  • Staubach, S., Pekmez, M. and Hanisch, F. G. (2016). Differential proteomics of urinary exovesicles from classical galactosemic patients reveals subclinical kidney insufficiency. J. Proteome Res. 15:1754–1761.
  • Su, Q., Peng, M., Zhang, Y., Xu, W., Darko, K. O., Tao, T., Huang, Y., Tao, X. and Yang, X. (2016). Quercetin induces bladder cancer cells apoptosis by activation of AMPK signaling pathway. Am. J. Cancer Res. 6:498–508.
  • Tortosa-Caparrós, E., Navas-Carrillo, D., Marín, F. and Orenes-Piñero, E. (2017). Anti-inflammatory effects of omega 3 and omega 6 polyunsaturated fatty acids in cardiovascular disease and metabolic syndrome. Crit. Rev. Food Sci. Nutr. 57:3421–3429.
  • Verdier, C., Ruidavets, J. B., Bongard, V., Taraszkiewicz, D., Martinez, L. O., Elbaz, M., Ferrières, J. and Perret, B. (2013). Association of hepatic lipase -514T allele with coronary artery disease and ankle-brachial index, dependence on the lipoprotein phenotype: the GENES study. PLoS One. 8:e67805.
  • Wang, D., Ma, J., Zhang, S., Hinney, A., Hebebrand, J., Wang, Y. and Wang, H. J. (2010). Association of the MC4R V103I polymorphism with obesity: a Chinese case-control study and meta-analysis in 55,195 individuals. Obesity (Silver Spring). 18:573–579.
  • Wang, X., Ouyang, Y., Liu, J., Zhu, M., Zhao, G., Bao, W. and Hu, F. B. (2014). Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. BMJ. 349:g4490.
  • Wang, H., Zhang, D., Ling, J., Lu, W., Zhang, S., Zhu, Y. and Lai, M. (2015). Gender specific effect of LIPC C-514T polymorphism on obesity and relationship with plasma lipid levels in Chinese children. J. Cell. Mol. Med. 19:2296–2306.
  • Wu, A. C., Gillman, M. W., Taveras, E. M. and Litonjua, A. A. (2009). INSIG2 is associated with lower gain in weight-for-length between birth and age 6 months. Clin. Med. Pediatrics. 3:33–37.
  • Xiang, Z., Proneth, B., Dirain, M. L., Litherland, S. A. and Haskell-Luevano, C. (2010). Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist. Biochemistry. 49:4583–4600.
  • Yang, Y., Ruiz-Narvaez, E., Kraft, P. and Campos, H. (2007). Effect of apolipoprotein E genotype and saturated fat intake on plasma lipids and myocardial infarction in the Central Valley of Costa Rica. Hum. Biol. 79:637–647.
  • Young, E. H., Wareham, N. J., Farooqi, S., Hinney, A., Hebebrand, J., Scherag, A., O'rahilly, S., Barroso, I. and Sandhu, M. S. (2007). The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Int. J. Obes. 31:1437–1441.
  • Zhang, Y., Tang, H. Q., Peng, W. J., Zhang, B. B. and Liu, M. (2015). Meta-analysis for the Association of Apolipoprotein E ϵ2/ϵ3/ϵ4 Polymorphism with Coronary Heart Disease. Chin. Med. J. (Engl). 128:1391–1398.

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