802
Views
8
CrossRef citations to date
0
Altmetric
Reviews

Could hop-derived bitter compounds improve glucose homeostasis by stimulating the secretion of GLP-1?

ORCID Icon, ORCID Icon, , ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon show all

References

  • Almaguer, C., C. Schönberger, M. Gastl, E. K. Arendt, and T. Becker. 2014. Humulus lupulus–a story that begs to be told. A review. J Inst Brew 120:289–314.
  • Andreozzi, P., G. Sarnelli, M. Pesce, F. P. Zito, A. D. Alessandro, V. Verlezza, I. Palumbo, F. Turco, K. Esposito, and R. Cuomo. 2015. The bitter taste receptor agonist quinine reduces calorie intake and increases the postprandial release of cholecystokinin in healthy subjects. J Neurogastroenterol Motil 21:511–9. doi:10.5056/jnm15028.
  • Arranz, S., G. Chiva-Blanch, P. Valderas-Martínez, A. Medina-Remón, R. M. Lamuela-Raventós, and R. Estruch. 2012. Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer. Nutrients 4:759–81. doi:10.3390/nu4070759.
  • Avau, B., and I. Depoortere. 2016. The bitter truth about bitter taste receptors: Beyond sensing bitter in the oral cavity. Acta Physiol (Oxf) 216:407–20. doi:10.1111/apha.12621.
  • Avau, B., A. Rotondo, T. Thijs, C. N. Andrews, P. Janssen, J. Tack, and I. Depoortere. 2015. Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation. Sci Rep 5:15985. doi:10.1038/srep15985.
  • Beulens, J. W., E. C. de Zoete, F. J. Kok, G. Schaafsma, and H. F. Hendriks. 2008. Effect of moderate alcohol consumption on adipokines and insulin sensitivity in lean and overweight men: A diet intervention study. Eur J Clin Nutr 62:1098–105. doi:10.1038/sj.ejcn.1602821.
  • Campbell, J. E., and D. J. Drucker. 2013. Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab 17:819–37. doi:10.1016/j.cmet.2013.04.008.
  • Champagne, A., and M. Boutry. 2017. A comprehensive proteome map of glandular trichomes of hop (Humulus lupulus L.) female cones: Identification of biosynthetic pathways of the major terpenoid-related compounds and possible transport proteins. Proteomics 17:1–10. doi:10.1002/pmic.201600411.
  • Chandrashekar, J., M. A. Hoon, N. J. Ryba, and C. S. Zuker. 2006. The receptors and cells for mammalian taste. Nature 444:288–94. doi:10.1038/nature05401.
  • Chang, W., L. Chen, and G. M. Hatch. 2015. Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies. Biochem Cell Biol 93:479–86. doi:10.1139/bcb-2014-0107.
  • Chiva-Blanch, G., S. Arranz, R. M. Lamuela-Raventos, and R. Estruch. 2013. Effects of wine, alcohol and polyphenols on cardiovascular disease risk factors: Evidences from human studies. Alcohol Alcohol 48:270–7. doi:10.1093/alcalc/agt007.
  • Costa, R., R. Negrão, I. Valente, Â. Castela, D. Duarte, L. Guardão, P. J. Magalhães, J. A. Rodrigues, J. T. Guimarães, P. Gomes, and R. Soares. 2013. Xanthohumol modulates inflammation, oxidative stress, and angiogenesis in type 1 diabetic rat skin wound healing. J Nat Prod 76:2047–53. doi:10.1021/np4002898.
  • Costa, R., I. Rodrigues, L. Guardão, S. Rocha-Rodrigues, C. Silva, J. Magalhães, M. Ferreira-de-Almeida, R. Negrão, and R. Soares. 2017. Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice. J Nutr Biochem 45:39–47. doi:10.1016/j.jnutbio.2017.03.006.
  • de Gaetano, G., S. Costanzo, A. Di Castelnuovo, L. Badimon, D. Bejko, A. Alkerwi, G. Chiva-Blanch, R. Estruch, C. La Vecchia, S. Panico, G. Pounis, F. Sofi, S. Stranges, M. Trevisan, F. Ursini, C. Cerletti, M. B. Donati, and L. Iacoviello. 2016. Effects of moderate beer consumption on health and disease: A consensus document. Nutr Metab Cardiovasc Dis 26:443–67. doi:10.1016/j.numecd.2016.03.007.
  • Depoortere, I. 2015. Taste receptors in the gut tune the release of peptides in response to nutrients. Peptides 66:9–12. doi:10.1016/j.peptides.2015.01.013.
  • Depoortere, I. 2014. Taste receptors of the gut: Emerging roles in health and disease. Gut 63:179–90. doi:10.1136/gutjnl-2013-305112.
  • Desai, A., V. R. Konda, G. Darland, M. Austin, K. S. Prabhu, J. S. Bland, B. J. Carroll, and M. L. Tripp. 2009. META060 inhibits multiple kinases in the NF-kappaB pathway and suppresses LPS–mediated inflammation in vitro and ex vivo. Inflamm Res 58:229–34. doi:10.1007/s00011-008-8162-y.
  • Domínguez Avila, J. A., J. Rodrigo García, G. A. González Aguilar, and L. A. de la Rosa. 2017. The antidiabetic mechanisms of polyphenols related to increased Glucagon-like Peptide-1 (GLP1) and insulin signaling. Molecules 22:903. doi:10.3390/molecules22060903.
  • Dotson, C. D., L. Zhang, H. Xu, Y. K. Shin, S. Vigues, S. H. Ott, A. E. Elson, H. J. Choi, H. Shaw, J. M. Egan, B. D. Mitchell, X. Li, N. I. Steinle, and S. D. Munger. 2008. Bitter taste receptors influence glucose homeostasis. PLoS One 3:e3974. doi:10.1371/journal.pone.0003974.
  • Everard, A., L. Geurts, M. Van Roye, N. M. Delzenne, and P. D. Cani. 2012. Tetrahydro iso-alpha acids from hops improve glucose homeostasis and reduce body weight gain and metabolic endotoxemia in high-fat diet-fed mice. PLoS One 7:e33858. doi:10.1371/journal.pone.0033858.
  • Ezcurra, M., F. Reimann, F. M. Gribble, and E. Emery. 2013. Molecular mechanisms of incretin hormone secretion. Curr Opin Pharmacol 13:922–7. doi:10.1016/j.coph.2013.08.013.
  • Hätönen, K. A., J. Virtamo, J. G. Eriksson, M. M. Perälä, H. K. Sinkko, J. Leiviskä, and L. M. Valsta. 2012. Modifying effects of alcohol on the postprandial glucose and insulin responses in healthy subjects. Am J Clin Nutr 96:44–9. doi:10.3945/ajcn.111.031682.
  • Hosaka, S., M. Miyashita, J. Inoue, and K. Maruyama. 2008. The short-term effect of alcoholic beverage-intake on blood glucose levels in type 2 diabetic patients. Diabetes Res Clin Pract 79:183–4. doi:10.1016/j.diabres.2007.08.008.
  • Huang, J., X. Wang, and Y. Zhang. 2017. Specific types of alcoholic beverage consumption and risk of type 2 diabetes: A systematic review and meta-analysis. J Diabetes Investig 8:56–68. doi:10.1111/jdi.12537.
  • Imhof, A., I. Plamper, S. Maier, G. Trischler, and W. Koenig. 2009. Effect of drinking on adiponectin in healthy men and women: A randomized intervention study of water, ethanol, red wine, and beer with or without alcohol. Diabetes Care 32:1101–3. doi:10.2337/dc08-1723.
  • International Organization for Standardization. ISO 26642:2010. 2010. Food products–determination of the glycaemic index (GI) and recommendation for food classification. Geneva, Switzerland: International Organization for Standardization. https://www.iso.org/standard/43633.html
  • Jang, H. J., Z. Kokrashvili, M. J. Theodorakis, O. D. Carlson, B. J. Kim, J. Zhou, H. H. Kim, X. Xu, S. L. Chan, M. Juhaszova, M. Bernier, B. Mosinger, R. F. Margolskee, and J. M. Egan. 2007. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 104:15069–74. doi:10.1073/pnas.0706890104.
  • Kao, T. H., and G. Y. Wu. 2013. Simultaneous determination of prenylflavonoid and hop bitter acid in beer lee by HPLC-DAD-MS. Food Chem 141:1218–26. doi:10.1016/j.foodchem.2013.04.032.
  • Katz, D. B., M. A. Nicolelis, and S. A. Simon. 2000. Nutrient tasting and signaling mechanisms in the gut. IV. There is more to taste than meets the tongue. Am J Physiol Gastrointest Liver Physiol 278:G6–9.
  • Kim, K. S., J. M. Egan, and H. J. Jang. 2014. Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways. Diabetologia 57:2117–25. doi:10.1007/s00125-014-3326-5.
  • Konda, V. R., A. Desai, G. Darland, J. S. Bland, and M. L. Tripp. 2010. META060 inhibits osteoclastogenesis and matrix metalloproteinases in vitro and reduces bone and cartilage degradation in a mouse model of rheumatoid arthritis. Arthritis Rheum 62:1683–92. doi:10.1002/art.27441.
  • Kondo, K. 2004. Beer and health: Preventive effects of beer components on lifestyle-related diseases. Biofactors 22:303–10. doi:10.1002/biof.5520220160.
  • Legette, L. L., A. Y. Luna, R. L. Reed, C. L. Miranda, G. Bobe, R. R. Proteau, and J. F. Stevens. 2013. Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats. Phytochemistry 91:236–41. doi:10.1016/j.phytochem.2012.04.018.
  • Li, J., J. Xu, R. Hou, X. Jin, J. Wang, N. Yang, L. Yang, L. Liu, F. Tao, and H. Lu. 2017. Qing-Hua granule induces GLP-1 secretion via bitter taste receptor in db/db mice. Biomed Pharmacother 89:10–17. doi:10.1016/j.biopha.2017.01.168.
  • Liu, M., P. E. Hansen, G. Wang, L. Qiu, J. Dong, H. Yin, Z. Qian, M. Yang, and J. Miao. 2015. Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus). Molecules 20:754–79. doi:10.3390/molecules20010754.
  • Lu, P., C. H. Zhang, L. M. Lifshitz, and R. ZhuGe. 2017. Extraoral bitter taste receptors in health and disease. J Gen Physiol 149:181–97. doi:10.1085/jgp.201611637.
  • Lu, S. S., Y. L. Yu, H. J. Zhu, X. D. Liu, L. Liu, Y. W. Liu, P. Wang, L. Xie, and G. J. Wang. 2009. Berberine promotes glucagon-like peptide-1 (7–36) amide secretion in streptozotocin-induced diabetic rats. J Endocrinol 200:159–65. doi:10.1677/JOE-08-0419.
  • Miranda, C. L., V. D. Elias, J. J. Hay, J. Choi, R. L. Reed, and J. F. Stevens. 2016. Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice. Arch Biochem Biophys 599:22–30. doi:10.1016/j.abb.2016.03.008.
  • Nogueira, L. C., R. F. do Rio, P. C. Lollo, and I. M. Ferreira. 2017. Moderate alcoholic beer consumption: The effects on the lipid profile and insulin sensitivity of adult men. J Food Sci 82:1720–5. doi:10.1111/1750-3841.13746.
  • Nozawa, H. 2005. Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice. Biochem Biophys Res Commun 336:754–61. doi:10.1016/j.bbrc.2005.08.159.
  • Obara, K., M. Mizutani, Y. Hitomi, H. Yajima, and K. Kondo. 2009. Isohumulones, the bitter component of beer, improve hyperglycemia and decrease body fat in Japanese subjects with prediabetes. Clin Nutr 28:278–84. doi:10.1016/j.clnu.2009.03.012.
  • Park, J., K. S. Kim, K. H. Kim, I. S. Lee, H. S. Jeong, Y. Kim, and H. J. Jang. 2015. GLP-1 secretion is stimulated by 1,10-phenanthroline via colocalized T2R5 signal transduction in human enteroendocrine L cell. Biochem Biophys Res Commun 468:306–11. doi:10.1016/j.bbrc.2015.10.107.
  • Pham, H., H. Hui, S. Morvaridi, J. Cai, S. Zhang, J. Tan, V. Wu, N. Levin, B. Knudsen, W. A. Goddard, S. J. Pandol, and R. Abrol. 2016. A bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells. Biochem Biophys Res Commun 475:295–300. doi:. doi:10.1016/j.bbrc.2016.04.149.
  • Rehfeld, J. F. 1998. The new biology of gastrointestinal hormones. Physiol Rev 78:1087–108.
  • Renaud, S., and M. de Lorgeril. 1992. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339:1523–6.
  • Rozengurt, N., S. V. Wu, M. C. Chen, C. Huang, C. Sternini, and E. Rozengurt. 2006. Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am J Physiol Gastrointest Liver Physiol 291:G792–802. doi:10.1152/ajpgi.00074.2006.
  • Shai, I., J. Wainstein, I. Harman-Boehm, I. Raz, D. Fraser, A. Rudich, and M. J. Stampfer. 2007. Glycemic effects of moderate alcohol intake among patients with type 2 diabetes: A multicenter, randomized, clinical intervention trial. Diabetes Care 30:3011–6. doi:10.2337/dc07-1103.
  • Shin, Y. K., B. Martin, E. Golden, C. D. Dotson, S. Maudsley, W. Kim, H. J. Jang, M. P. Mattson, D. J. Drucker, J. M. Egan, and S. D. Munger. 2008. Modulation of taste sensitivity by GLP-1 signaling. J Neurochem 106:455–63. doi:10.1111/j.1471-4159.2008.05397.x.
  • Sluik, D., N. Jankovic, M. Hughes, M. G. O'Doherty, B. Schöttker, W. Drygas, O. Rolandsson, S. Männistö, J. M. Ordóñez-Mena, J. Ferrieres, C. Bamia, G. de Gaetano, J. C. Kiefte-De Jong, O. H. Franco, I. Sluijs, A. M. W. Spijkerman, S. Sans, S. Eriksson, D. Kromhout, A. Trichopoulou, T. Wilsgaard, H. Brenner, K. Kuulasmaa, T. Laatikainen, S. Söderberg, L. Iacoviello, P. Boffetta, F. Kee, and E. J. M. Feskens. 2017. Alcoholic beverage preference and diabetes incidence across Europe: The Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES) project. Eur J Clin Nutr 71:659–68. doi:10.1038/ejcn.2017.4.
  • Steenackers, B., L. De Cooman, and D. De Vos. 2015. Chemical transformations of characteristic hop secondary metabolites in relation to beer properties and the brewing process: A review. Food Chem 172:742–56. doi:10.1016/j.foodchem.2014.09.139.
  • Steinert, R. E., C. Beglinger, and W. Langhans. 2016. Intestinal GLP-1 and satiation: From man to rodents and back. Int J Obes (Lond) 40:198–205.
  • Stevens, J. F., A. W. Taylor, J. E. Clawson, and M. L. Deinzer. 1999a. Fate of xanthohumol and related prenylflavonoids from hops to beer. J Agric Food Chem 47:2421–8. doi:10.1021/jf990101k.
  • Stevens, J. F., A. W. Taylor, and M. L. Deinzer. 1999b. Quantitative analysis of xanthohumol and related prenylflavonoids in hops and beer by liquid chromatography-tandem mass spectrometry. J Chromatogr A 832:97–107. doi:10.1016/S0021-9673(98)01001-2.
  • Taniguchi, Y., Y. Matsukura, H. Taniguchi, H. Koizumi, and M. Katayama. 2015. Development of preparative and analytical methods of the hop bitter acid oxide fraction and chemical properties of its components. Biosci Biotechnol Biochem 79:1684–94. doi:10.1080/09168451.2015.1042832.
  • Traversy, G., and J. P. Chaput. 2015. Alcohol consumption and obesity: An update. Curr Obes Rep 4:122–30. doi:10.1007/s13679-014-0129-4.
  • Troke, R. C., T. M. Tan, and S. R. Bloom. 2014. The future role of gut hormones in the treatment of obesity. Ther Adv Chronic Dis 5:4–14. doi:10.1177/2040622313506730.
  • USDA National Nutrient Database for Standard Reference. 2017. Release 27. U.S. Department of Agriculture, Agricultural Research Service: 2017. http://ndb.nal.usda.gov/ndb/foods.
  • Wong, G. T., K. S. Gannon, and R. F. Margolskee. 1996. Transduction of bitter and sweet taste by gustducin. Nature 381:796–800. doi:10.1038/381796a0.
  • Yan, W., G. Sunavala, S. Rosenzweig, M. Dasso, J. G. Brand, and A. I. Spielman. 2001. Bitter taste transduced by PLC-beta(2)-dependent rise in IP(3) and alpha-gustducin-dependent fall in cyclic nucleotides. Am J Physiol Cell Physiol 280:C742–51.
  • Yu, Y., G. Hao, Q. Zhang, W. Hua, M. Wang, W. Zhou, S. Zong, M. Huang, and X. Wen. 2015. Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways. Biochem Pharmacol 97:173–7. doi:10.1016/j.bcp.2015.07.012.
  • Yu, Y., L. Liu, X. Wang, X. Liu, X. Liu, L. Xie, and G. Wang. 2010. Modulation of glucagon-like peptide-1 release by berberine: In vivo and in vitro studies. Biochem Pharmacol 79:1000–6. doi:10.1016/j.bcp.2009.11.017.
  • Zanchi, D., A. Depoorter, L. Egloff, S. Haller, L. Mählmann, U. E. Lang, J. Drewe, C. Beglinger, A. Schmidt, and S. Borgwardt. 2017. The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review. Neurosci Biobehav Rev 80:457–75. doi:10.1016/j.neubiorev.2017.06.013.
  • Zhang, X., X. Liang, H. Xiao, and Q. Xu. 2004. Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. J Am Soc Mass Spectrom 15:180–7. doi:10.1016/j.jasms.2003.09.014.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.