Vitamin D supplementation and non-alcoholic fatty liver disease: A critical and systematic review of clinical trials

References

• Abenavoli, L., N. Milic, L. Di Renzo, T. Preveden, M. Medic-Stojanoska, and A. De Lorenzo. 2016. Metabolic aspects of adult patients with nonalcoholic fatty liver disease. World J Gastroenterol 22:7006–16. doi:10.3748/wjg.v22.i31.7006.
   PubMed Web of Science ®Google Scholar
• Adams, J. S., and M. Hewison 2010. Update in vitamin D. J Clin Endocrinol Metab 95:471–78. doi:10.1210/jc.2009-1773.
   PubMed Web of Science ®Google Scholar
• Alexandra, S.-G., D. C. Georgiana, C. Nicoleta, P. M. Daniela, S. Traian, and S. Veronica 2013. Apa I and Taq I polymorphisms of VDR (vitamin D receptor) gene in association with susceptibility to tuberculosis in the Romanian population. Rom Biotech Lett 18:7956.
   Web of Science ®Google Scholar
• Altieri, B., W. B. Grant, S. Della Casa, F. Orio, A. Pontecorvi, A. Colao, G. Sarno, and G. Muscogiuri 2017. Vitamin D and pancreas: The role of sunshine vitamin in the pathogenesis of diabetes mellitus and pancreatic cancer. Crit Rev Food Sci Nutr 57:3472–88. doi:10.1080/10408398.2015.1136922.
   PubMed Web of Science ®Google Scholar
• Barchetta, I., F. Angelico, M. Del Ben, M. G. Baroni, P. Pozzilli, S. Morini, and M. G. Cavallo 2011. Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes. BMC Med 9:85. doi:10.1186/1741-7015-9-85.
   PubMed Web of Science ®Google Scholar
• Barchetta, I., M. Del Ben, F. Angelico, M. Di Martino, A. Fraioli, G. La Torre, R. Saulle, L. Perri, S. Morini, C. Tiberti, L. Bertoccini, F. A. Cimini, F. Panimolle, C. Catalano, M. G. Baroni, and M. G. Cavallo 2016. No effects of oral vitamin D supplementation on non-alcoholic fatty liver disease in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. BMC Med 14:92. doi:10.1186/s12916-016-0638-y.
   PubMed Web of Science ®Google Scholar
• Beilfuss, J., V. Berg, M. Sneve, R. Jorde, and E. Kamycheva 2012. Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects. Cytokine 60 (3):870–74. doi:10.1016/j.cyto.2012.07.032.
   PubMed Web of Science ®Google Scholar
• Beilfuss, A., J.-P. Sowa, S. Sydor, M. Beste, L. P. Bechmann, M. Schlattjan, W.-K. Syn, I. Wedemeyer, Z. Mathé, C. Jochum, G. Gerken, R. K. Gieseler, and A. Canbay. 2014. Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently. Gut 64 (5):791–99. doi:10.1136/gutjnl-2014-307024.
   PubMed Web of Science ®Google Scholar
• Breitkopf, K., P. Godoy, L. Ciuclan, M. V. Singer, and S. Dooley. 2006. TGF-beta/Smad signaling in the injured liver. Z Gastroenterol 44:57–66. doi:10.1055/s-2005-858989.
   PubMed Web of Science ®Google Scholar
• Cani, P. D., R. Bibiloni, C. Knauf, A. Waget, A. M. Neyrinck, N. M. Delzenne, and R. Burcelin 2008. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57:1470–81. doi:10.2337/db07-1403.
   PubMed Web of Science ®Google Scholar
• Challoumas, D. 2014. Vitamin D supplementation and lipid profile: What does the best available evidence show?. Atherosclerosis 235:130–39. doi:10.1016/j.atherosclerosis.2014.04.024.
   PubMed Web of Science ®Google Scholar
• Cheah, M. C., A. J. McCullough, and G. B. Goh 2017. Current modalities of Fibrosis assessment in Non-alcoholic Fatty Liver Disease. J Clin Transl Hepatol 5:261–71.
   PubMed Web of Science ®Google Scholar
• Clark, J. M., F. L. Brancati, and A. M. Diehl 2002. Nonalcoholic fatty liver disease. Gastroenterology 122:1649–57. doi:10.1053/gast.2002.33573.
   PubMed Web of Science ®Google Scholar
• Cobbold, J. F., D. Patel, and S. D. Taylor-Robinson 2012. Assessment of inflammation and fibrosis in non-alcoholic fatty liver disease by imaging-based techniques. J Gastroenterol Hepatol 27:1281–92. doi:10.1111/j.1440-1746.2012.07127.x.
   PubMed Web of Science ®Google Scholar
• Consolo, M., A. Amoroso, D. Spandidos, and M. Mazzarino 2009. Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease. Int J Mol Med 24:143–52.
   PubMed Web of Science ®Google Scholar
• Dankers, W., E. M. Colin, J. P. van Hamburg, and E. Lubberts 2016. Vitamin D in Autoimmunity: Molecular mechanisms and Therapeutic potential. Front Immunol 7:697.
   PubMed Web of Science ®Google Scholar
• de Ledinghen, V., J. Vergniol, J. Foucher, F. El-Hajbi, W. Merrouche, and V. Rigalleau 2010. Feasibility of liver transient elastography with FibroScan using a new probe for obese patients. Liver Int 30:1043–48. doi:10.1111/j.1478-3231.2010.02258.x.
   PubMed Web of Science ®Google Scholar
• Dowman, J. K., J. W. Tomlinson, and P. N. Newsome 2010. Pathogenesis of non-alcoholic fatty liver disease. Qjm 103:71–83. doi:10.1093/qjmed/hcp158.
   PubMed Web of Science ®Google Scholar
• Dowman, J. K., J. W. Tomlinson, and P. N. Newsome 2011. Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment Pharmacol Ther 33:525–40. doi:10.1111/j.1365-2036.2010.04556.x.
   PubMed Web of Science ®Google Scholar
• Downs, S. H., and N. Black 1998. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 52:377–84. doi:10.1136/jech.52.6.377.
   PubMed Web of Science ®Google Scholar
• Eliades, M., E. Spyrou, N. Agrawal, M. Lazo, F. L. Brancati, J. J. Potter, A. A. Koteish, J. M. Clark, E. Guallar, and R. Hernaez 2013. Meta-analysis: vitamin D and non-alcoholic fatty liver disease. Aliment Pharmacol Ther 38:246–54. doi:10.1111/apt.12377.
   PubMed Web of Science ®Google Scholar
• Eliades, M., and E. Spyrou. 2015. Vitamin D: a new player in non-alcoholic fatty liver disease?. World J Gastroenterol 21:1718–27. doi:10.3748/wjg.v21.i6.1718.
   PubMed Web of Science ®Google Scholar
• Farrell, G. C., and C. Z. Larter 2006. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43:s99–112. doi:10.1002/hep.20973.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick, E., and A. Dhawan 2014. Noninvasive biomarkers in non-alcoholic fatty liver disease: current status and a glimpse of the future. World J Gastroenterol 20:10851–863. doi:10.3748/wjg.v20.i31.10851.
   PubMed Web of Science ®Google Scholar
• Foroughi, M., Z. Maghsoudi, R. Ghiasvand, B. Iraj, and G. Askari 2014. Effect of Vitamin D Supplementation on C-reactive protein in patients with Nonalcoholic Fatty Liver. Int J Prev Med 5:969–75.
   PubMedGoogle Scholar
• Geier, A. 2011. Shedding new light on vitamin D and fatty liver disease. J Hepatol 55:273–75. doi:10.1016/j.jhep.2010.12.026.
   PubMed Web of Science ®Google Scholar
• Hannon, T. S., S. E. Kahn, K. M. Utzschneider, T. A. Buchanan, K. J. Nadeau, P. S. Zeitler, D. A. Ehrmann, S. A. Arslanian, S. Caprio, S. L. Edelstein, P. J. Savage, and K. J. Mather 2017. Review of methods for measuring beta-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium. Diabetes Obes Metab. (In press): doi:10.1111/dom.13005.
   PubMed Web of Science ®Google Scholar
• Heaney, R. P. 2008. Nutrients, endpoints, and the problem of proof. J Nutr 138:1591–95.
   PubMed Web of Science ®Google Scholar
• Heaney, R. P. 2012. Vitamin D–baseline status and effective dose. N Engl J Med 367:77–78. doi:10.1056/NEJMe1206858.
   PubMed Web of Science ®Google Scholar
• Higgins, J. P., S. G. Thompson, J. J. Deeks, and D. G. Altman 2003. Measuring inconsistency in meta-analyses. Bmj 327:557–60. doi:10.1136/bmj.327.7414.557.
   PubMed Web of Science ®Google Scholar
• Holick, M. F. 2007. Vitamin D deficiency. N Engl J Med 357:266–81. doi:10.1056/NEJMra070553.
   PubMed Web of Science ®Google Scholar
• Holick, M. F., N. C. Binkley, H. A. Bischoff-Ferrari, C. M. Gordon, D. A. Hanley, R. P. Heaney, M. H. Murad, and C. M. Weaver. 2011. Evaluation, treatment, and prevention of vitamin d deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 96:1911–30. doi:10.1210/jc.2011-0385.
   PubMed Web of Science ®Google Scholar
• Hyppönen, E., B. J. Boucher, D. J. Berry, and C. Power 2008. 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age. Diabetes 57:298–305. doi:10.2337/db07-1122.
   PubMed Web of Science ®Google Scholar
• Jou, J., S. S. Choi, and A. M. Diehl 2008. Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis 28:370–79. doi:10.1055/s-0028-1091981.
   PubMed Web of Science ®Google Scholar
• Kitson, M. T., A. Pham, A. Gordon, W. Kemp, and S. K. Roberts 2016. High-dose vitamin D supplementation and liver histology in NASH. Gut 65:717–18. doi:10.1136/gutjnl-2015-310417.
   PubMed Web of Science ®Google Scholar
• Liberati, A., D. G. Altman, J. Tetzlaff, C. Mulrow, P. C. Gotzsche, J. P. Ioannidis, M. Clarke, P. J. Devereaux, J. Kleijnen, and D. Moher 2009. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 6:e1000100. doi:10.1371/journal.pmed.1000100.
   PubMed Web of Science ®Google Scholar
• Lorvand Amiri, H., S. Agah, J. Tolouei Azar, S. Hosseini, F. Shidfar, and S. N. Mousavi 2016. Effect of daily calcitriol supplementation with and without calcium on disease regression in non-alcoholic fatty liver patients following an energy-restricted diet: Randomized, controlled, double-blind trial. Clin Nutr. (In Press); doi:10.1016/j.clnu.2016.09.020.
   PubMed Web of Science ®Google Scholar
• Maestro, B., S. Molero, S. Bajo, N. Dávila, and C. Calle. 2002. Transcriptional activation of the human insulin receptor gene by 1, 25‐dihydroxyvitamin D3. Cell Biochem Funct 20:227–32. doi:10.1002/cbf.951.
   PubMed Web of Science ®Google Scholar
• Maestro, B., N. Dávila, M. C. Carranza, and C. Calle. 2003. Identification of a Vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol 84:223–30. doi:10.1016/S0960-0760(03)00032-3.
   PubMed Web of Science ®Google Scholar
• Major, G. C., F. P. Alarie, J. Dore, and A. Tremblay 2009. Calcium plus vitamin D supplementation and fat mass loss in female very low-calcium consumers: potential link with a calcium-specific appetite control. Br J Nutr 101:659–63. doi:10.1017/S0007114508030808.
   PubMed Web of Science ®Google Scholar
• Miura, K., and H. Ohnishi. 2014. Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease. World J Gastroenterol 20:7381–91. doi:10.3748/wjg.v20.i23.7381.
   PubMed Web of Science ®Google Scholar
• Nakano, T., Y. F. Cheng, C. Y. Lai, L. W. Hsu, Y. C. Chang, J. Y. Deng, Y. Z. Huang, H. Honda, K. D. Chen, and C. C. Wang. 2011. Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. J Hepatol 55:415–25. doi:10.1016/j.jhep.2010.11.028.
   PubMed Web of Science ®Google Scholar
• National Heart, Lung, and Blood Institute. Quality Assessment Tool for Before-After (Pre-Post) Studies with no Control Group [updated March, 2014]. Available from: https://www.nhlbi.nih.gov/health-pro/guidelines/in-develop/cardiovascularrisk-reduction/tools/before-after
   Google Scholar
• Nelson, J. E., C. L. Roth, L. A. Wilson, K. P. Yates, B. Aouizerat, V. Morgan-Stevenson, E. Whalen, A. Hoofnagle, M. Mason, V. Gersuk, M. M. Yeh, and K. V. Kowdley 2016. Vitamin D Deficiency is associated with increased risk of Non-alcoholic Steatohepatitis in adults with Non-alcoholic Fatty Liver Disease: Possible role for MAPK and NF-kappaB?. Am J Gastroenterol 111:852–63. doi:10.1038/ajg.2016.51.
   PubMed Web of Science ®Google Scholar
• Nosratabadi, R., M. K. Arababadi, and V. A. Salehabad 2015. Vitamin D receptor polymorphisms in type 2 diabetes in southeastern Iranian patients. Lab Med 42:32–34. doi:10.1309/LMW788XEEYVVLBUV.
   Web of Science ®Google Scholar
• Papapostoli, I., F. Lammert, and C. S. Stokes 2016. Effect of Short-Term Vitamin D correction on Hepatic Steatosis as quantified by Controlled Attenuation Parameter (CAP). J Gastrointestin Liver Dis 25:175–181.
   PubMed Web of Science ®Google Scholar
• Park, D., H. Kwon, S. W. Oh, H. K. Joh, S. S. Hwang, J. H. Park, J. M. Yun, H. Lee, G. E. Chung, S. Ze, J. H. Park, Y. Bae, and A. Lee 2017. Is Vitamin D an independent risk factor of Nonalcoholic Fatty Liver Disease?: A cross-sectional study of the healthy population. J Korean Med Sci 32:95–101. doi:10.3346/jkms.2017.32.1.95.
   PubMed Web of Science ®Google Scholar
• Picciano, M. F. 2010. Vitamin D status and health. Crit Rev Food Sci Nutr 50:24–25. doi:10.1080/10408398.2010.526858.
   Web of Science ®Google Scholar
• Pittas, A. G., J. Lau, F. B. Hu, and B. Dawson-Hughes 2007. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92:2017–29. doi:10.1210/jc.2007-0298.
   PubMed Web of Science ®Google Scholar
• Pittas, A. G., and B. Dawson-Hughes 2010. Vitamin D and diabetes. J Steroid Biochem Mol Biol 121:425–29. doi:10.1016/j.jsbmb.2010.03.042.
   PubMed Web of Science ®Google Scholar
• Poeta, M., L. Pierri, and P. Vajro 2017. Gut-Liver axis derangement in Non-Alcoholic Fatty Liver Disease. Children (Basel) 4:66. doi:10.3390/children4080066
   PubMedGoogle Scholar
• Prosser, D. E., and G. Jones 2004. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci 29:664–73. doi:10.1016/j.tibs.2004.10.005.
   PubMed Web of Science ®Google Scholar
• Saleh, H. A., and A. H. Abu-Rashed 2007. Liver biopsy remains the gold standard for evaluation of chronic hepatitis and fibrosis. J Gastrointestin Liver Dis 16:425–26.
   PubMed Web of Science ®Google Scholar
• Shab-Bidar, S., T. R. Neyestani, and A. Djazayery 2011. Efficacy of vitamin D3-fortified-yogurt drink on anthropometric, metabolic, inflammatory and oxidative stress biomarkers according to vitamin D receptor gene polymorphisms in type 2 diabetic patients: a study protocol for a randomized controlled clinical trial. BMC Endocr Disord 11:12.
   PubMed Web of Science ®Google Scholar
• Sharifi, N., R. Amani, E. Hajiani, and B. Cheraghian 2014. Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial. Endocrine 47:70–80.
   PubMed Web of Science ®Google Scholar
• Sharifi, N., R. Amani, E. Hajiani, and B. Cheraghian 2016. Women may respond different from men to vitamin D supplementation regarding cardiometabolic biomarkers. Exp Biol Med (Maywood) 241:830–38.
   PubMed Web of Science ®Google Scholar
• Tabrizi, R., M. Moosazadeh, K. B. Lankarani, M. Akbari, S. T. Heydari, F. Kolahdooz, M. Samimi, and Z. Asemi 2017. The effects of vitamin D supplementation on metabolic profiles and liver function in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Syndr. (In Press): doi:10.1016/j.dsx.2017.07.025
   PubMed Web of Science ®Google Scholar
• Takiishi, T., C. Gysemans, R. Bouillon, and C. Mathieu. 2012. Vitamin D and diabetes. Rheum Dis Clin North Am 38:179–206.
   PubMed Web of Science ®Google Scholar
• Targher, G., L. Bertolini, L. Scala, M. Cigolini, L. Zenari, G. Falezza, and G. Arcaro 2007. Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 17:517–24.
   PubMed Web of Science ®Google Scholar
• Wang, D., H. Lin, M. Xia, Q. Aleteng, X. Li, H. Ma, B. Pan, J. Gao, and X. Gao 2016a. Vitamin D Levels are inversely associated with Liver Fat Content and Risk of Non-Alcoholic Fatty Liver Disease in a Chinese middle-aged and elderly population: The Shanghai Changfeng study. PLoS One 11:e0157515.
   PubMedGoogle Scholar
• Wang, N., H. Zhai, C. Zhu, Q. Li, B. Han, Y. Chen, C. Zhu, Y. Chen, F. Xia, D. Lin, and Y. Lu 2016b. Combined association of Vitamin D and Sex Hormone Binding Globulin with Nonalcoholic Fatty Liver Disease in men and Postmenopausal women: A cross-sectional study. Medicine (Baltimore) 95:e2621.
   PubMed Web of Science ®Google Scholar
• Zhai, H. L., N. J. Wang, B. Han, Q. Li, Y. Chen, C. F. Zhu, Y. C. Chen, F. Z. Xia, Z. Cang, C. X. Zhu, M. Lu, and Y. L. Lu 2016. Low vitamin D levels and non-alcoholic fatty liver disease, evidence for their independent association in men in East China: a cross-sectional study (Survey on Prevalence in East China for Metabolic Diseases and Risk Factors (SPECT-China)). Br J Nutr 115:1352–59. doi:10.1017/S0007114516000386.
   PubMed Web of Science ®Google Scholar
• Zhu, C. G., Y. X. Liu, H. Wang, B. P. Wang, H. Q. Qu, B. L. Wang, and M. Zhu 2017. Active form of vitamin D ameliorates non-alcoholic fatty liver disease by alleviating oxidative stress in a high-fat diet rat model. Endocr J 64:663–73. doi:10.1507/endocrj.EJ16-0542.
   PubMed Web of Science ®Google Scholar
• Zittermann, A., S. Frisch, H. K. Berthold, C. Götting, J. Kuhn, K. Kleesiek, P. Stehle, H. Koertke, and R. Koerfer 2009. Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr 89:1321–27. doi:10.3945/ajcn.2008.27004.
   PubMed Web of Science ®Google Scholar
• Zúñiga, S., D. Firrincieli, C. Housset, and N. Chignard. 2011. Vitamin D and the vitamin D receptor in liver pathophysiology. Clin Res Hepatol Gastroenterol 35:295–302. doi:10.1016/j.clinre.2011.02.003.
   PubMed Web of Science ®Google Scholar