Effect of inositol and its derivatives on diabetes: a systematic review

References

• Adams, G. G., S. Imran, S. Wang, A. Mohammad, M. S. Kok, D. A. Gray, G. A. Channell, and S. E. Harding. 2014. The hypoglycemic effect of pumpkin seeds, trigonelline (TRG), nicotinic acid (NA), and D-Chiro-inositol (DCI) in controlling glycemic levels in diabetes mellitus. Critical Reviews in Food Science and Nutrition 54 (10):1322–9. doi:10.1080/10408398.2011.635816
   PubMed Web of Science ®Google Scholar
• Antony, P. J., G. R. Gandhi, A. Stalin, K. Balakrishna, E. Toppo, K. Sivasankaran, S. Ignacimuthu, and N. A. Al-Dhabi. 2017. Myoinositol ameliorates high-fat diet and streptozotocin-induced diabetes in rats through promoting insulin receptor signaling. Biomedicine & Pharmacotherapy 88:1098–113. doi:10.1016/j.biopha.2017.01.170.
   PubMed Web of Science ®Google Scholar
• Brownlee, M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature 414 (6865):813–20. doi:10.1038/414813a
   PubMed Web of Science ®Google Scholar
• Corrado, F., R. D’Anna, G. Di Vieste, D. Giordano, B. Pintaudi, A. Santamaria, and A. Di Benedetto. 2011. The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes. Diabetic Medicine 28 (8):972–5. doi:10.1111/j.1464-5491.2011.03284.x.
   PubMed Web of Science ®Google Scholar
• Croze, M. L., A. Geloen, and C. O. Soulage. 2015. Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation. British Journal of Nutrition 113 (12):1862–75. doi:10.1017/S000711451500121X.
   PubMed Web of Science ®Google Scholar
• Croze, M. L., and C. O. Soulage. 2013. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie 95 (10):1811–27. doi:10.1016/j.biochi.2013.05.011
   PubMed Web of Science ®Google Scholar
• D'Anna, R., A. Di Benedetto, A. Scilipoti, A. Santamaria, M. L. Interdonato, E. Petrella, I. Neri, B. Pintaudi, F. Corrado, and F. Facchinetti. 2015. Myo-inositol supplementation for prevention of gestational diabetes in obese pregnant women: A randomized controlled trial. Obstetrics & Gynecology 126:310–5. doi:10.1097/AOG.0000000000000958.
   PubMed Web of Science ®Google Scholar
• D'Anna, R., A. Scilipoti, D. Giordano, C. Caruso, M. L. Cannata, M. L. Interdonato, F. Corrado, and A. Di Benedetto. 2013. Myo-Inositol supplementation and onset of gestational diabetes mellitus in pregnant women with a family history of type 2 diabetes: A prospective, randomized, placebo-controlled study. Diabetes Care 36:854–7. doi:10.2337/dc12-1371.
   PubMed Web of Science ®Google Scholar
• Farias, V. X., F. H. P. Macêdo, M. B. Oquendo, A. R. Tomé, S. N. Báo, D. O. S. Cintra, C. F. Santos, A. A. C. Albuquerque, D. B. Heimark, J. Larner, et al. 2011. Chronic treatment with d‐chiro‐inositol prevents autonomic and somatic neuropathy in STZ‐induced diabetic mice. Diabetes, Obesity and Metabolism 13 (3):243–50., doi:10.1111/j.1463-1326.2010.01344.x.
   PubMed Web of Science ®Google Scholar
• Foster, S. R., F. O. Omoruyi, J. Bustamante, R. L. Lindo, and L. L. Dilworth. 2016. The effect of combined inositol hexakisphosphate and inositol supplement in streptozotocin-induced type 2 diabetic rats. International Journal of Experimental Pathology 97 (5):397–407. doi:10.1111/iep.12210.
   PubMed Web of Science ®Google Scholar
• Gao, Y. F., M. N. Zhang, T. X. Wang, T. C. Wu, R. D. Ai, and Z. S. Zhang. 2016. Hypoglycemic effect of D-chiro-inositol in type 2 diabetes mellitus rats through the PI3K/Akt signaling pathway. Molecular and Cellular Endocrinology 433:26–34. doi:10.1016/j.mce.2016.05.013.
   PubMed Web of Science ®Google Scholar
• Govindarajan, C., R. Pitchaipillai, B. Shanmugasundaram, S. Thangam, J. Arokiasamy, and M. S. Pillai. 2015. Myoinositol: A review of its use in patients with polycystic ovary syndrome. World Journal of Pharmaceutical Sciences 4:137–55.
   Google Scholar
• Haroon, E., K. Watari, A. Thomas, O. Ajilore, J. Mintz, V. Elderkin-Thompson, C. Darwin, S. Kumaran, and A. Kumar. 2009. Prefrontal myo-inositol concentration and visuospatial functioning among diabetic depressed patients. Psychiatry Research: Neuroimaging 171 (1):10–9. doi:10.1016/j.pscychresns.2008.03.006.
   Web of Science ®Google Scholar
• Heikkilä, O., N. Lundbom, M. Timonen, P. H. Groop, S. Heikkinen, and S. Mäkimattila. 2009. Hyperglycaemia is associated with changes in the regional concentrations of glucose and myo-inositol within the brain. Diabetologia 52 (3):534–40. doi:10.1007/s00125-008-1242-2
   PubMed Web of Science ®Google Scholar
• Hernández-Mijares, A., C. Bañuls, S. Rovira-Llopis, Á. Álvarez, S. Orden, O. Rubio-Puchol, V. M. Víctor, and M. Rocha. 2015. Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes. Journal of Functional Foods 18:598–607. doi:10.1016/j.jff.2015.08.025.
   Web of Science ®Google Scholar
• Hong, J. H., H. W. Jang, Y. E. Kang, J. H. Lee, K. S. Kim, H. J. Kim, K. R. Park, and B. J. Ku. 2012. Urinary chiro-and myo-inositol levels as a biological marker for type 2 diabetes mellitus. Disease Markers 33 (4):193–9. doi:10.1155/2012/734718.
   PubMed Web of Science ®Google Scholar
• Larner, J. 2002. D-chiro-inositol-its functional role in insulin action and its deficit in insulin resistance. International Journal of Experimental Diabetes Research 3 (1):47–60. doi:10.1080/15604280212528
   PubMedGoogle Scholar
• Lee, J. Y., Y. R. Kim, J. Park, and S. Kim. 2012. Inositol polyphosphate multikinase signaling in the regulation of metabolism. Annals of the New York Academy of Sciences 1271 (1):68–74. doi:10.1111/j.1749-6632.2012.06725.x.
   PubMed Web of Science ®Google Scholar
• Mancini, M., A. Andreassi, M. Salvioni, F. Pelliccione, G. Mantellassi, and G. Banderali. 2016. Myoinositol and D-Chiro inositol in improving insulin resistance in obese male children: Preliminary data. International Journal of Endocrinology 2016:8720342.
   PubMed Web of Science ®Google Scholar
• Croze, M. L., R. E. Vella, N. J. Pillon, H. A. Soula, L. Hadji, M. Guichardant, and C. O. Soulage. 2013. Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice. The Journal of Nutritional Biochemistry 24 (2):457–66. doi:10.1016/j.jnutbio.2012.01.008.
   PubMed Web of Science ®Google Scholar
• Matarrelli, B., E. Vitacolonna, M. D’angelo, G. Pavone, P. A. Mattei, M. Liberati, and C. Celentano. 2013. Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trial. Journal of Maternal-Fetal and Neonatal Medicine 26 (10):967–72. doi:10.3109/14767058.2013.766691.
   PubMed Web of Science ®Google Scholar
• Maurizi, A. R., M. Menduni, R. Del Toro, S. Kyanvash, D. Maggi, C. Guglielmi, A. L. Pantano, G. Defeudis, E. Fioriti, S. Manfrini, and P. Pozzilli. 2017. A pilot study of d-chiro-inositol plus folic acid in overweight patients with type 1 diabetes. Acta Diabetologica 54 (4):361–5. doi:10.1007/s00592-016-0954-x
   PubMed Web of Science ®Google Scholar
• Murphy, A., A. Shamshirsaz, D. Markovic, R. Ostlund, and B. Koos. 2016. Urinary excretion of Myo-Inositol and D-Chiro-Inositol in early pregnancy is enhanced in gravidas with gestational diabetes mellitus. Reproductive Sciences 23 (3):365–71. doi:10.1177/1933719115602767.
   PubMed Web of Science ®Google Scholar
• Muscogiuri, G., S. Palomba, A. S. Lagana, and F. Orio. 2016. Inositols in the treatment of Insulin-Mediated diseases. International Journal of Endocrinology 2016:3058393. doi:10.1155/2016/3058393.
   PubMed Web of Science ®Google Scholar
• Nissen, P. M., C. Nebel, N. Oksbjerg, and H. C. Bertram. 2010. Metabolomics reveals relationship between plasma inositols and birth weight: possible markers for fetal programming of type 2 diabetes. BioMed Research International 2011:8.
   Google Scholar
• Pintaudi, B., G. Di Vieste, and M. Bonomo. 2016. The effectiveness of Myo-Inositol and D-Chiro inositol treatment in type 2 diabetes. International Journal of Endocrinology 2016:9132052.
   PubMed Web of Science ®Google Scholar
• Plows, J. F., F. Budin, R. A. Andersson, V. J. Mills, K. Mace, S. T. Davidge, M. H. Vickers, P. N. Baker, I. Silva-Zolezzi, and J. L. Stanley. 2017. The effects of myo-inositol and B and D vitamin supplementation in the db/+ mouse model of gestational diabetes mellitus. Nutrients 9 (2):141.
   PubMed Web of Science ®Google Scholar
• Santamaria, A., F. Corrado, G. Baviera, G. Carlomagno, V. Unfer, and R. D’anna. 2016. Second trimester amniotic fluid myo-inositol concentrations in women later developing gestational diabetes mellitus or pregnancy-induced hypertension. Journal of Maternal-Fetal and Neonatal Medicine 29 (14):2245–7. doi:10.3109/14767058.2015.1081886
   PubMed Web of Science ®Google Scholar
• Santamaria, A., A. Di Benedetto, E. Petrella, B. Pintaudi, F. Corrado, R. D'Anna, I. Neri, and F. Facchinetti. 2016. Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial. Journal of Maternal-Fetal and Neonatal Medicine 29:3234–7. doi:10.3109/14767058.2015.1121478.
   PubMed Web of Science ®Google Scholar
• Şat, İ. G., and K. Keleş. 2004. Fitik Asit Ve Beslenmeye Etkisi. Gıda 29:405–9.
   Google Scholar
• Scioscia, M., S. Kunjara, K. Gumaa, P. McLean, C. H. Rodeck, and T. W. Rademacher. 2007. Urinary excretion of inositol phosphoglycan P-type in gestational diabetes mellitus. Diabetic Medicine 24 (11):1300–4. doi:10.1111/j.1464-5491.2007.02267.x.
   PubMed Web of Science ®Google Scholar
• Scioscia, M., S. Kunjara, K. Gumaa, A. M. Gomez Galan, P. McLean, C. H. Rodeck, and T. W. Rademacher. 2007. Altered urinary release of inositol phosphoglycan A-type in women with gestational diabetes mellitus. Gynecologic and Obstetric Investigation 64 (4):217–23. doi:10.1159/000106494.
   PubMed Web of Science ®Google Scholar
• Steinberg, H. O., M. Tarshoby, R. Monestel, G. Hook, J. Cronin, A. Johnson, B. Bayazeed, and A. D. Baron. 1997. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. Journal of Clinical Investigation 100 (5):1230. doi:10.1172/JCI119636.
   PubMed Web of Science ®Google Scholar
• Suzuki, S.,. H. Kawasaki, Y. Satoh, M. Ohtomo, M. Hirai, A. Hirai, S. Hirai, M. Onoda, M. Matsumoto, Y. Hinokio, et al. 1994. Urinary chiro-inositol excretion is an index marker of insulin sensitivity in Japanese type II diabetes. Diabetes Care 17 (12):1465–8., doi:10.2337/diacare.17.12.1465.
   PubMed Web of Science ®Google Scholar
• Suzuki, S.,. C. Suzuki, Y. Hinokio, Y. Ishigaki, H. Katagiri, M. Kanzaki, V. N. Azev, N. Chakraborty, and M. d'Alarcao. 2014. Insulin-mimicking bioactivities of acylated inositol glycans in several mouse models of diabetes with or without obesity. PloS One 9 (6):e100466. doi:10.1371/journal.pone.0100466
   PubMed Web of Science ®Google Scholar
• Unfer, V., J. E. Nestler, Z. A. Kamenov, N. Prapas, and F. Facchinetti. 2016. Effects of inositol(s) in women with PCOS: A systematic review of randomized controlled trials. International Journal of Endocrinology 2016:1. doi:10.1155/2016/1849162.
   Web of Science ®Google Scholar
• Yao, Y.,. F. Shan, J. Bian, F. Chen, M. Wang, and G. Ren. 2008. D-chiro-inositol-enriched tartary buckwheat bran extract lowers the blood glucose level in KK-Ay mice. Journal of Agricultural and Food Chemistry 56 (21):10027–31. doi:10.1021/jf801879m.
   PubMed Web of Science ®Google Scholar