Management of hyperuricemia through dietary polyphenols as a natural medicament: A comprehensive review

References

• Aggarwal, B. B., A. Bhardwaj, R. S. Aggarwal, N. P. Seeram, S. Shishodia, and Y. Takada. 2004. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 24:2783–2840.
   PubMed Web of Science ®Google Scholar
• Ahmed, D., P. Dar, R. Chaudhery, and R. Masih. 2017. Chemical constituents of Lagenaria siceraria mesocarp and its xanthine oxidase and alpha-amylase inhibitory activities. Int. J. Fruit Sci. 17:310–322.
   Web of Science ®Google Scholar
• Aras, B., N. Kalfazade, V. Tuğcu, E. Kemahlı, B. Özbay, H. Polat, and A. İ. Taşçı. 2008. Can lemon juice be an alternative to potassium citrate in the treatment of urinary calcium stones in patients with hypocitraturia? A prospective randomized study. Urol. Res. 36:313.
   PubMedGoogle Scholar
• Arimboor, R., and C. Arumughan. 2012. Effect of polymerization on antioxidant and xanthine oxidase inhibitory potential of sea buckthorn (H. rhamnoides) proanthocyanidins. J. Food Sci. 77:1036–41.
   Web of Science ®Google Scholar
• Azmi, S. M. N., P. Jamal, and A. Amid 2012. Xanthine oxidase inhibitory activity from potential Malaysian medicinal plant as remedies for gout. Int. Food. Res. 19:159–165.
   Google Scholar
• Badimon, L., G. Vilahur, and T. Padro 2010. Nutraceuticals and atherosclerosis: human trials. Cardiovasc. Ther. 28:202–215.
   PubMed Web of Science ®Google Scholar
• Bakhiya, A., A. Bahn, G. Burckhardt, and N. Wolff. 2003. Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Cell. Physiol. Biochem. 13:249–256.
   PubMed Web of Science ®Google Scholar
• Baltas, N. 2017. Investigation of a wild pear species (Pyrus elaeagnifolia subsp. elaeagnifolia Pallas) from Antalya, Turkey: polyphenol oxidase properties and anti-xanthine oxidase, anti-urease and antioxidant activity. Int. J. Food Prop. 20:585–595.
   Web of Science ®Google Scholar
• Bell, P. G., D. C. Gaze, G. W. Davison, T. W. George, M. J. Scotter, and G. Howatson. 2014. Montmorency tart cherry (Prunus cerasus L.) concentrate lowers uric acid, independent of plasma cyanidin-3-O-glucosiderutinoside. J. Funct. Foods. 11:82–90.
   Web of Science ®Google Scholar
• Bhatti, S. K., J. H. O'Keefe, and C. J. Lavie. 2013. Coffee and tea: perks for health and longevity? Curr. Opin. Clin. Nutr. Metab. Care. 16:688–697.
   PubMed Web of Science ®Google Scholar
• Bhole, V., J. W. Choi, S. W. Kim, M. de Vera, and H. Choi. 2010. Serum Uric Acid Levels and the Risk of Type 2 Diabetes: A Prospective study. Am. J. Med. 123:957–961.
   PubMed Web of Science ®Google Scholar
• Blau, L. W. 1950. Cherry diet control for gout and arthritis. Tex. Rep. Biol. Med. 8:09e11.
   Google Scholar
• Bravo, L. 1998) Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr. Rev. 56:317–333.
   PubMed Web of Science ®Google Scholar
• Brook, R. A., A. Forsythe, J. E. Smeeding, and N. L. Edwards. 2010. Chronic gout: epidemiology, disease progression, treatment and disease burden. Curr. Med. Res. Opin. 26:2813–2821.
   PubMed Web of Science ®Google Scholar
• Brownlee, M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature. 414:813–820.
   PubMed Web of Science ®Google Scholar
• Calderon, C. S. J. P.E., M. G. S. Pedro, A. M. Reyes, P. J. Salom, A. R. Sanchez, H. Sandigan, et al. 2015. Antihyperuricemic and aephroprotective effects of carica papaya aqueous leaf extract in a murine model of hyperuricemia and acute renal tissue injury. DLSU Research Congress 2015 De La Salle University, Manila, Philippines March 2–4.
   Google Scholar
• Candan, F. 2003. Effect of Rhus coriaria L. (Anacardiaceae) on superoxide radical scavenging and xanthine oxidase activity. J. Enzyme Inhib. Med. Chem. 18:59–62.
   PubMed Web of Science ®Google Scholar
• Cecchini, T. 1992. Enciclopedia de las hierbas medicinales, Editorial D. Vecchi.
   Google Scholar
• Cheatham, C. L., I. Vazquez-Vidal, A. Medlin, and V. S. Voruganti. 2016. Blueberry consumption affects serum uric acid concentrations in older adults in a sex-specific manner. Antioxidants. 5:43.
   Web of Science ®Google Scholar
• Chen, G., M. L. Tan, K. K. Li, P. C. Leung, and C. H. Ko. 2015. Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice. J. Ethnopharmacol. 175:14–20.
   PubMed Web of Science ®Google Scholar
• Chen, L. X., and H. R. Schumacher 2008. Gout: an evidence-based review. J. Clin. Rheumatol. 14:S55–S62.
   PubMed Web of Science ®Google Scholar
• Chen, S. Y., C. L. Chen, M. L. Shen, and N. Kamatani. 2003) Trends in the manifestations of gout in Taiwan, Rheumatol. 42:1529–1533.
   PubMed Web of Science ®Google Scholar
• Chiang, H. C., and Y. Y. Chen. 1993. Xanthine oxidase inhibitors from the roots of eggplant (Solanum melongena L.). J. Enzyme Inhib. 7:225–235.
   Web of Science ®Google Scholar
• Choi, H. K., and G. Curhan. 2007. Coffee, tea, and caffeine consumption and serum uric acid level: the third national health and nutrition examination survey. Arthritis Care. Res. 57:816–821.
   Web of Science ®Google Scholar
• Cos, P., L. Ying, M. Calomme, J. P. Hu, K. Cimanga, B. Van Poel, and D. V. Berghe. 1998. Structure- activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers. J. Nat. Prod. 61:71–76.
   PubMed Web of Science ®Google Scholar
• Crittenden, D. B., and M. H. Pillinger. 2013. New therapies for gout. Annu. Rev. Med. 64:325–337.
   PubMed Web of Science ®Google Scholar
• Dalbeth, N., S. Kumar, L. Stamp, and P. Gow. 2006. Dose adjustment of allopurinol according to creatinine clearance does not provide adequate control of hyperuricemia in patients with gout. J. Rheumatol. 33:1646–1650.
   PubMed Web of Science ®Google Scholar
• de Oliveira, E. P., and R. C. Burini 2012. High plasma uric acid concentration: causes and consequences. Diabetol. Metab. Syndr. 4:12.
   PubMed Web of Science ®Google Scholar
• Dew, T. P., A. J. Day, and M. R. Morgan. 2005. Xanthine oxidase activity in vitro: effects of food extracts and components. J. Agric. Food. Chem. 53:6510–6515.
   PubMed Web of Science ®Google Scholar
• Dinour, D., N. K. Gray, S. Campbell, X. Shu, L. Sawyer, W. Richardson, G. Rechavi, N. Amariglio, L. Ganon, B. A. Sela, and H. Bahat 2010. “Homozygous SLC2A9 mutations cause severe renal hypouricemia.” J. Am. Soc. Nephrol. 21:64–72.
   PubMed Web of Science ®Google Scholar
• Domb, A. J., and N. Kumar (Eds.). 2011. Biodegradable polymers in clinical use and clinical development, John Wiley & Sons.
   Google Scholar
• Dong, Y., H. Huang, M. Zhao, D. Sun-Waterhouse, L. Lin, and C. Xiao. 2016. Mechanisms underlying the xanthine oxidase inhibitory effects of dietary flavonoids galangin and pinobanksin. J. Funct. Foods. 24:26–36.
   Web of Science ®Google Scholar
• El-Rahman, H. S. A., and N. A. Abd-Elhak 2015. Xanthine oxidase inhibitory activity and antigout of celery leek parsley and molokhia. Adv. Biochem. 3:40–50.
   Google Scholar
• Engerman, R. L., and T. S. Kern. 1993. Aldose reductase inhibition fails to prevent retinopathy in diabetic and galactosemic dogs. Diabetes. 42:820–825.
   PubMed Web of Science ®Google Scholar
• Eraly, S. A., V. Vallon, T. Rieg, J. A. Gangoiti, W. R. Wikoff, G. Siuzdak, B. A. Barshop, and S. K. Nigam. 2008. Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol. Genomics. 33:180–192.
   PubMed Web of Science ®Google Scholar
• Ewadh, M. J., M. F. Smaism, A. M. Jawad, S. Mkhlof, O. M. Aljubouri, and M. M. Ewadh. 2015. Using Soursop Extracts for Natural Gout Treatment. Am. J. Biosci. Bioeng. 3:37–39.
   Google Scholar
• Fam. 2002. Gout, diet and the insulin resistance syndrome. J. Rheumatol. 29:1350–1355.
   PubMed Web of Science ®Google Scholar
• Flemmig, J., K. Kuchta, J. Arnhold, and H. W. Rauwald. 2011. Olea europaea leaf (Ph. Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. Phytomedicine. 18:561–566.
   PubMed Web of Science ®Google Scholar
• Gawlik-Dziki, U., M. Świeca, and D. Sugier. 2012a. Enhancement of antioxidant abilities and the lipoxygenase and xanthine oxidase inhibitory activity of broccoli sprouts by biotic elicitors. Acta Sci. Pol. Hortorum Cultus. 11:13–25.
   Web of Science ®Google Scholar
• Gawlik-Dziki, U. 2012b. Dietary spices as a natural effectors of lipoxygenase, xanthine oxidase, peroxidase and antioxidant agents. Lebensm. Wiss. Technol. 47:138–146.
   Web of Science ®Google Scholar
• Gawlik-Dziki, U., D. Dziki, M. Świeca, and R. Nowak. 2017. Mechanism of action and interactions between xanthine oxidase inhibitors derived from natural sources of chlorogenic and ferulic acids. Food Chem. 225:138–145.
   PubMed Web of Science ®Google Scholar
• Gimeno, S. G. A., D. Rodrigues, E. N. Canó, E. E. S. Lima, M. Schaper, H. Pagliaro, M. M. Lafer, and R. G. Baruzzi. 2009. Cardiovascular risk factors among Brazilian Karib indigenous peoples: upper Xingu, Central Brazil, 2000–3. J. Epidemiol. Community Health. 63:299–304.
   PubMed Web of Science ®Google Scholar
• Gliozzi, M., N. Malara, S. Muscoli, and V. Mollace. 2016.The treatment of hyperuricemia. Int. J. Cardiol. 213:23–27.
   PubMed Web of Science ®Google Scholar
• González-Castejón, M., and A. Rodriguez-Casado. 2011. Dietary phytochemicals and their potential effects on obesity: a review. Pharmacol. Res. 64:438–455.
   PubMed Web of Science ®Google Scholar
• Gosling, A. L., E. Matisoo-Smith, and T. R. Merriman 2014.Hyperuricaemia in the Pacific: why the elevated serum urate levels? Rheumatol. Int. 34:743–757.
   PubMed Web of Science ®Google Scholar
• Guana, S., Z. Tanga, X. Fanga, X. Wua, H. Liua, C. Wang, and C. Hou. 2016. Prevalence of hyperuricemia among Beijing post-menopausal women in 10 years. Arch. Gerontol. Geriatr. 64:162–166.
   PubMed Web of Science ®Google Scholar
• Gustafsson, D., and R. Unwin 2013. The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality. BMC Nephrol. 14:164.
   PubMed Web of Science ®Google Scholar
• Haidari, F., S. A. Keshavarz, M. R. Rashidi, and M. M. Shahi 2009a. Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity. J. Clin. Biochem. Nutr. 45:285–291.
   PubMed Web of Science ®Google Scholar
• Haidari, F., M. R. Rashidi, M. R. Eshraghian, S. A. Mahboob, M. M. Shahi, and S. A. Keshavarz. 2008. Hyperuricemic and antioxidant activities of Alliul cepa Lilliaceac and quercetin in normal and hyperuricemic rats. Saudi Med. J. 29:1573–1579.
   PubMed Web of Science ®Google Scholar
• Haidari, F., M. M. Shahi, S. A. Keshavarz, and M. R. Rashidi. 2009b. Inhibitory effects of tart cherry (Prunus cerasus) juice on xanthine oxidoreductase Activity and its hypouricemic and antioxidant effects on rats. Malays. J. Nutr. 15:53–64.
   PubMedGoogle Scholar
• Harborne, J. B., and H. Baxter 1999. The handbook of natural flavonoids. Volume 1 and Volume 2, John Wiley and Sons.
   Google Scholar
• Harris, M. A. R. K., L. R. Bryant, P. A. T.R I C. K. Danaher, and J. E. F.F R E. Y. Alloway. 2000. Effect of low dose daily aspirin on serum urate levels and urinary excretion in patients receiving probenecid for gouty arthritis. J. Rheumatol. 27:2873–2876.
   PubMed Web of Science ®Google Scholar
• He, Y. H., J. Zhou, Y. S. Wang, C. Xiao, Y. Tong, J. C. O. Tang, A. S. C. Chan, and A. P. Lu. 2006. Anti‐inflammatory and anti‐oxidative effects of cherries on Freund's adjuvant‐induced arthritis in rats. Scand. J. Rheumatol. 35:356–358.
   PubMed Web of Science ®Google Scholar
• Honda, S., and T. Masuda. 2016. Identification of pyrogallol in the ethyl acetate-soluble part of coffee as the main contributor to its xanthine oxidase inhibitory activity. J. Agric. Food Chem. 64:7743–7749.
   PubMed Web of Science ®Google Scholar
• Honda, S., Y. Miura, A. Masuda, and T. Masuda 2014. Identification of crypto-and neochlorogenic lactones as potent xanthine oxidase inhibitors in roasted coffee beans. Biosci. Biotechnol. Biochem. 78:2110–2116.
   PubMed Web of Science ®Google Scholar
• Hosomi, A., T. Nakanishi, T. Fujita, and I. Tamai. 2012. Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. PLoS One. 7, 0030456.
   PubMed Web of Science ®Google Scholar
• Hou, C. W., Y. C. Lee, H. F. Hung, H. W. Fu, and K. C. Jeng 2012. Longan seed extract reduces hyperuricemia via modulating urate transporters and suppressing xanthine oxidase activity. Am. J. Chin. Med. 40:979–991.
   PubMed Web of Science ®Google Scholar
• Hu, Q. H., X. Zhang, X. Wang, R. Q. Jiao, and L. D. Kong. 2012. Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice. Eur. J. Clin. Nutr. 51:593–606.
   Google Scholar
• Huo, L. N., W. Wang, C. Y. Zhang, H. B. Shi, Y. Liu, X. H. Liu, B. H. Guo, D. M. Zhao, and H. Gao. 2015. Bioassay-guided isolation and identification of xanthine oxidase inhibitory constituents from the leaves of Perilla frutescens. Molecules. 20:17848–17859.
   PubMed Web of Science ®Google Scholar
• Hwa, K. S., D. M. Chung, Y. C. Chung, and H. K. Chun. 2011. Hypouricemic effects of anthocyanin extracts of purple sweet potato on potassium oxonate-induced hyperuricemia in mice. Phytother. Res. 2011, 25:1415–1417.
   Google Scholar
• Ichida, K., M. Hosoyamada, H. Kimura, M. Takeda, Y. Utsunomiya, T. Hosoya, and H. Endou. 2003. Urate transport via human PAH transporter hOAT1 and its gene structure. Kidney Int. 63:143–155.
   PubMed Web of Science ®Google Scholar
• Irondi, E. A., S. O. Agboola, G. Oboh, A. A. Boligon, and M. L. Athayde, Shode, and F. O. 2016a. Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in-vitro. J. Intercult. Ethnopharmacol. 5:122.
   PubMed Web of Science ®Google Scholar
• Irondi, E. A., G. Oboh, S. O. Agboola, A. A. Boligon, and M. L. Athayde. 2016b. Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidase and Fe 2+-induced lipid peroxidation in the kidney, liver, and lungs tissues of rat's in-vitro. Food Sci. Human Well. 5:17–23.
   Google Scholar
• Jacob, R. A., G. M. Spinozzi, V. A. Simon, D. S. Kelley, R. L. Prior, B. Hess-Pierce, and A. A. Kader. 2003. Consumption of cherries lowers plasma urate in healthy women. J. Nutr. 133:1826–1829.
   PubMed Web of Science ®Google Scholar
• Jhang, J. J., J. W. Ong, C. C. Lu, C. L. Hsu, J. H. Lin, J. W. Liao, and G. C. Yen. 2016. Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in-vitro and in-vivo. Food Funct. 7:4239–4246.
   PubMed Web of Science ®Google Scholar
• Jiang, Y., X. Y. You, K. L. Fu, and W. L. Yin. 2012. Effects of extract from Mangifera indica leaf on monosodium urate crystal-induced gouty arthritis in rats. J. Evid Based Complementary Altern Med. doi:10.1155/2012/967573.
   Google Scholar
• Kamatani, Y., K. Matsuda, Y. Okada, M. Kubo, N. Hosono, Y. Daigo, Y. Nakamura, and N. Kamatani. 2010. Genome-wide association study of hematological and biochemical traits in a Japanese population. Nat. Genet. 42:210–215.
   PubMed Web of Science ®Google Scholar
• Katrine, L. W., A. A. Riedel, N. Joseph-Ridge, and W. Robert. 2004. Increasing prevalence of gout and hyperuricemia over 10 years among older adult in a managed care population. J. Rheumatol. 31:1582–1587.
   PubMed Web of Science ®Google Scholar
• Kelley, D. S., R. Rasooly, R. A. Jacob, A. A. Kader, and B. E. Mackey. 2006. Consumption of bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women. J. Nutr. 136:981–986.
   PubMed Web of Science ®Google Scholar
• Kelley, E. E., N. K. Khoo, N. J. Hundley, U. Z. Malik, B. A. Freeman, and M. M. Tarpey. 2010. Hydrogen peroxide is the major oxidant product of xanthine oxidase. Free Radic. Biol. Med. 48:493–498.
   PubMed Web of Science ®Google Scholar
• Kim, D. W., M. J. Curtis-Long, H. J. Yuk, Y. Wang, Y. H. Song, S. H. Jeong, and K. H. Park. 2014. Quantitative analysis of phenolic metabolites from different parts of Angelica keiskei by HPLC–ESI MS/MS and their xanthine oxidase inhibition. Food Chem. 153:20–27.
   PubMed Web of Science ®Google Scholar
• Kim, S., S. H. Park, H. N. Lee, and T. Park 2008. Prunus mume extract ameliorates exercise-induced fatigue in trained rats. J. Med Food. 2008, 11:460–468.
   PubMed Web of Science ®Google Scholar
• Kiyohara, C., S. Kono, S. Honjo, I. Todoroki, Y. Sakurai, M. Nishiwaki, H. Hamada, H. Nishikawa, H. Koga, S. Ogawa, and K. Nakagawa. 1999. Inverse association between coffee drinking and serum uric acid concentrations in middle-aged Japanese males. Br. J. Nutr. 82:125–130.
   PubMed Web of Science ®Google Scholar
• Kolz, M., T. Johnson, S. Sanna, A. Teumer, V. Vitart, M. Perola, and Å. Johansson. 2009. Meta- analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 5:98–111.
   Web of Science ®Google Scholar
• Kondo, M., Y. Hirano, M. Nishio, Y. Furuya, H. Nakamura, and T. Watanabe. 2013. Xanthine oxidase inhibitory activity and hypouricemic effect of aspalathin from unfermented rooibos. J. Food Sci. 78:H1935–9.
   PubMed Web of Science ®Google Scholar
• Kono, R., Y. Okuno, K. I. Inada, A. Tokuda, H. Hashizume, M. Yoshida, M. Nakamura, and H. Utsunomiya. 2011. A Prunus mume extract stimulated the proliferation and differentiation of osteoblastic MC3T3-E1 cells. BioSci. Biotechnol. Biochem. 75:1907–1911.
   PubMed Web of Science ®Google Scholar
• Krishnan, E. 2014. Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome: NHANES 2009–2010. J. Am. Heart Assoc. 3:e000157.
   PubMed Web of Science ®Google Scholar
• Kulaksızoğlu, S., M. Sofikerim, and C. Çevik. 2008. In-vitro effect of lemon and orange juices on calcium oxalate crystallization. Int. Urol. Nephrol. 40:589–594.
   PubMed Web of Science ®Google Scholar
• Kuo, C. Y., E. S. Kao, K. C. Chan, H. J. Lee, T. F. Huang, and C. J. Wang. 2012. Hibiscus sabdariffa L. extracts reduce serum uric acid levels in oxonate-induced rats. J. Funct Food. 4:375–381.
   Web of Science ®Google Scholar
• Kuo, C.-F., M. J. Grainge, W. Zhang, and M. Doherty. 2015. Global epidemiology of gout: prevalence, incidence and risk factors. Nat. Rev. Rheumatol. 11:649–662.
   PubMed Web of Science ®Google Scholar
• Lawrence, R. C., D. T. Felson, C. G. Helmick, L. M. Arnold, H. Choi, R. A. Deyo, S. Gabriel, R. Hirsch, M. C. Hochberg, and G. G. Hunder. 2008. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II. Arthritis Rheum. 58:26–35.
   PubMed Web of Science ®Google Scholar
• Lee, C. T., L. C. Chang, C. W. Liu, and P. F. Wu. 2017. Negative correlation between serum uric acid and kidney URAT1 mRNA expression caused by resveratrol in rats. Mol. Nutr. Food Res. 10.1002/mnfr.201601030.
   Web of Science ®Google Scholar
• Leporatti, M. L., E. Posocco, and A. Pavesi. 1985. Some new therapeutic uses of several medicinal plants in the province of Terni (Umbria, Central Italy). J. Ethnopharmacol. 14:65–68.
   PubMed Web of Science ®Google Scholar
• Les, F., J. M. Prieto, J. M. Arbonés-Mainar, M. S. Valero, and V. López. 2015. Bioactive properties of commercialised pomegranate (Punica granatum) juice: antioxidant, antiproliferative and enzyme inhibiting activities. Food Funct. 6, 2049–2057.
   PubMed Web of Science ®Google Scholar
• Lespade, L., and S. Bercion. 2009. Theoretical study of the mechanism of inhibition of xanthine oxidase by flavonoids and gallic acid derivatives. J. Phys. Chem. B. 114:921–928.
   Web of Science ®Google Scholar
• Li, X., P. Song, J. Li, P. Wang, and G. Li. 2015. Relationship between hyperuricemia and dietary risk factors in Chinese adults: a cross-sectional study. Rheumatol Int. 35:2079–2089.
   PubMed Web of Science ®Google Scholar
• Li, Y., P. Lai, J. Chen, H. Shen, B. Tang, L. Wu, and M. Weng. 2016. Extraction optimization of polyphenols, antioxidant and xanthine oxidase inhibitory activities from Prunus salicina Lindl. Food Sci. Technol (Campinas). 36:520–525.
   Google Scholar
• Lin, S., G. Zhang, Y. Liao, and J. Pan. 2015a. Inhibition of chrysin on xanthine oxidase activity and its inhibition mechanism. Int. J. Biol. Macromolec. 81:274–282.
   PubMed Web of Science ®Google Scholar
• Lin, S., G. Zhang, Y. Liao, J. Pan, and D. Gong. 2015 b. Dietary flavonoids as xanthine oxidase inhibitors: structure–affinity and structure–activity relationships. J. Agric. Food. Chem. 63:7784–7794.
   PubMed Web of Science ®Google Scholar
• Lin, S., G. Zhang, J. Pan, and D. Gong. 2015 c. Deciphering the inhibitory mechanism of genistein on xanthine oxidase in-vitro. J. Photochem. Photobiol. B. 153:463–472.
   PubMed Web of Science ®Google Scholar
• Liu, B., T. Wang, H. Zhao, W. Yue, H. Yu, C. Liu, J. Yin, R. Jia, and H. Nie. 2011. The prevalence of hyperuricemia in China: a meta-analysis. BMC public health. 11:832.
   PubMed Web of Science ®Google Scholar
• Liu, C. M., T. H. Tung, P. Chou, V. T. K. Chen, C. T. Hsu, W. S. Chien, Y. T. Lin, H. F. Lu, H. C. Shih, and J. H. Liu. 2006 Clinical correlation of gallstone disease in a Chinese population in Taiwan: experience at Cheng Hsin General Hospital. World J. Gastroenterol. 12:1281.
   PubMed Web of Science ®Google Scholar
• Liu, F., C. Deng, W. Cao, G. Zeng, X. Deng, and Y. Zhou. 2017. Phytochemicals of Pogostemon Cablin (Blanco) Benth. aqueous extract: their xanthine oxidase inhibitory activities. Biomed. Pharmacother. 89:544–548.
   PubMed Web of Science ®Google Scholar
• Liu, K., W. Wang, B. H. Guo, H. Gao, Y. Liu, X. H. Liu, et al. 2016a. Chemical evidence for potent xanthine oxidase inhibitory activity of ethyl acetate extract of Citrus aurantium l. dried immature fruits. Molecules, 21:302.
   PubMed Web of Science ®Google Scholar
• Liu, L., Y. F. Qing, and G. Zhou. 2016b. “Research progress about URAT1 in Gout/hyperuricemia medical recapitulate. Medical Recapitulate. 6:( Chinese).
   Google Scholar
• Liu, R., C. Han, D. Wu, X. Xia, J. Gu, H. Guan, Z. Shan, and W. Teng. 2015. Prevalence of Hyperuricemia and gout in mainland China from 2000 to 2014: A systematic review and meta-analysis. Bio. Med. Res. Inter. 762820.
   Google Scholar
• Lohsoonthorn, V., B. Dhanamun, and M. A. Williams. 2006. Prevalence of hyperuricemia and its relationship with metabolic syndrome in Thai adults receiving annual health exams. Arch. Med. Res. 37:883–889.
   PubMed Web of Science ®Google Scholar
• Matsuo, H., K. Yamamoto, H. Nakaoka, A. Nakayama, M. Sakiyama, T. Chiba, A. Takahashi, T. Nakamura, H. Nakashima, Y. Takada, and I. Danjoh. 2015. Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. Ann. Rheum. Dis. annrheumdis-2014–206191.
   PubMed Web of Science ®Google Scholar
• Mertz, D., and H. Loewer. 1992. First indications of decrease in the incidence of hyperuricemia in North Germany. Versicherungsmedizin. 44:211–214.
   PubMedGoogle Scholar
• Mittal, A., A. R. Phillips, B. Loveday, and J. A. Windsor. 2008. The potential role for xanthine oxidase inhibition in major intra-abdominal surgery. World J. Surg. 32:288–295.
   PubMed Web of Science ®Google Scholar
• Mo, S. F., F. Zhou, Y. Z. Lv, Q. H. Hu, D. M. Zhang, and L. D. Kong. 2007. Hypouricemic action of selected flavonoids in mice: structure–activity relationships. Biol. Pharm. Bull. 30:1551–1556.
   PubMed Web of Science ®Google Scholar
• Mohamed, D. A., and S. Y. Al-Okbi 2008. Evaluation of anti-gout activity of some plant food extracts. Pol. J. Food Nutr. 58:389–395.
   Google Scholar
• Moriwaki, Y., C. Okuda, A. Yamamoto, T. Ka, Z. Tsutsumi, S. Takahashi, T. Yamamoto, K. Kitadate, and K. Wakame. 2011. Effects of Oligonol®, an oligomerized polyphenol formulated from lychee fruit, on serum concentration and urinary excretion of uric acid. J. Funct. Foods. 3:13–16.
   Web of Science ®Google Scholar
• Mulvihill, E. E., and M. W. Huff. 2010. Antiatherogenic properties of flavonoids: implications for cardiovascular health, Can. J. Cardiol. 26:17A–21A.
   PubMed Web of Science ®Google Scholar
• Muthiah, P. L. 2012. In-vitro xanthine oxidase inhibitory activity of leaves, fruits and peel extract of Citrus aurantium, Citrus limetta and Citrus limon. Int. J. Phytopharm. 2:77–80.
   Google Scholar
• Nabipour, I., P. N. Sambrook, F. M. Blyth, M. R. Janu, L. M. Waite, V. Naganathan, D. G. Handelsman, D. G. Le Couteur, R. G. Cumming, and M. J. Seibel. 2011. Serum uric acid is associated with bone health in older men: a cross-sectional population-based study. J. Bone. Miner. Res. 26:955–964.
   PubMed Web of Science ®Google Scholar
• Nagahama, K., K. Iseki, T. Inoue, T. Touma, Y. Ikemiya, and S. Takishita 2004. Hyperuricemia and cardiovascular risk factor clustering in a screened cohort in Okinawa, Japan. Hypertens Res. 27:227–233.
   PubMed Web of Science ®Google Scholar
• Nakamura, K., M. Sakurai, K. Miura, Y. Morikawa, K. Yoshita, M. Ishizaki, T. Kido, Y. Naruse, Y. M. Suwazono, and H. Nakagawa. 2012. Alcohol intake and the risk of hyperuricaemia: a 6-year prospective study in Japanese men. Nutr. Metab. Cardiovasc. Dis. 22:989–996.
   PubMed Web of Science ®Google Scholar
• Nakanishi, T., M. Nishl, A. Inada, H. Obata, N. Tanabe, S. Abe, and M. Wakashiro 1990. Two new potent inhibitors of xanthine oxidase from leaves of Perilla frutescens Britton var. acuta Kudo. Chem. Pharm. Bull. 38:1772–1774.
   PubMed Web of Science ®Google Scholar
• Nan, H., Q. Qiao, Y. Dong, W. Gao, B. Tang, R. Qian, and T. Tuomilehto. 2006. The prevalence of hyperuricemia in a population of the coastal city of Qingdao. China. J. Rheumatol. 33:1346–1350.
   PubMed Web of Science ®Google Scholar
• Ngoc, T. M., N. M. Khoi, N. X. Nhiem, B. H. Tai, D. Van Don, H. Van Luong, D. C. Son, and K. Bae. 2012. Xanthine oxidase inhibitory activity of constituents of Cinnamomum cassia twigs. Bioorg. Med. Chem. Lett. 22:4625–4628.
   PubMed Web of Science ®Google Scholar
• Nile, S. H., and C. N. Khobragade. 2011. Phytochemical analysis, antioxidant and xanthine oxidase inhibitory activity of Tephrosia purpurea Linn root extract. Indian J. Nat. Prod. Resour. 2:52–58.
   Google Scholar
• Nile, S. H., and S. W. Park. 2013. Total phenolics, antioxidant and xanthine oxidase inhibitory activity of three colored onions (Allium cepa L.). Front. Biosci. 7:224–228.
   Google Scholar
• Nile, S. H., and S. W. Park. 2015. Chromatographic analysis, antioxidant, anti-inflammatory, and xanthine oxidase inhibitory activities of ginger extracts and its reference compounds. Ind. Crops Prod. 70:238–244.
   Web of Science ®Google Scholar
• Nile, S. H., A. S. Nile, Y. S. Keum, and K. Sharma. 2017. Utilization of quercetin and quercetin glycosides from onion (Allium cepa L.) solid waste as an antioxidant, urease and xanthine oxidase inhibitors. Food Chem. 235:119–126.
   PubMed Web of Science ®Google Scholar
• Nile, S. H., Park, and S. W. 2014. Antioxidant, α‐glucosidase and xanthine oxidase inhibitory activity of bioactive compounds from maize (Zea mays L.). Chem. Biol. Drug Des. 83:119–125.
   PubMed Web of Science ®Google Scholar
• Nobili, S., D. Lippi, E. Witort, M. Donnini, L. Bausi, E. Mini, and S. Capaccioli. 2009. Natural compounds for cancer treatment and prevention. Pharmacol. Res. 59:365–378.
   PubMed Web of Science ®Google Scholar
• Noor Hashim, N. H., F. Abas, K. Shaari, and N. H. Lajis. 2013. Antioxidant and xanthine oxidase inhibitory activities of Persicaria hydropiper. Int. J. Food Prop. 16:1028–1036.
   Web of Science ®Google Scholar
• Palu, A., S. Deng, B. West, and J. Jensen 2009. Xanthine oxidase inhibiting effects of noni (Morinda citrifolia) fruit juice. Phytother. Res. 23:1790–1791.
   PubMed Web of Science ®Google Scholar
• Perez-Ruiz, F., N. Dalbeth, and T. Bardin. 2015. A review of uric acid, crystal deposition disease, and gout. Adv. Ther. 32:31–41.
   PubMed Web of Science ®Google Scholar
• Pieroni, A., V. Janiak, C. M. Du¨rr, S. Lu¨deke, E. Trachsel, and M. Heinrich. 2002. In-vitro antioxidant activity of non-cultivated vegetables of ethnic albanians in southern Italy. Phytother. Res. 16:467–473.
   PubMed Web of Science ®Google Scholar
• Qian, Y. U., H. C. Shen, Y. C. Hu, Y. F. Chen, and T. H. Tung 2017. Prevalence and metabolic factors of hyperuricemia in an elderly agricultural and fishing population in Taiwan. Arch. Rheumatol. 32:149–157.
   PubMed Web of Science ®Google Scholar
• Qiu, L., X. Q. Cheng, J. Wu, J. T. Liu, T. Xu, H. T. Ding, Y. H. Liu, Z. M. Ge, Y. J. Wang, H. J. Han, and J. Liu. 2013. Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces. BMC public health. 13:664.
   PubMed Web of Science ®Google Scholar
• Ramassamy, C. 2006. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur. J. Pharmacol. 545:51–64.
   PubMed Web of Science ®Google Scholar
• Rees, F., M. Hui, and M. Doherty. 2014. Optimizing current treatment of gout. Nat. Rev. Rheumatol. 10:271–283.
   PubMed Web of Science ®Google Scholar
• Robinson, P. C., and S. Horsburgh 2014. Gout: joints and beyond, epidemiology, clinical features, treatment and co-morbidities. Maturitas. 78:245–251.
   PubMed Web of Science ®Google Scholar
• Robinson, T., W. Taylor, and T. Merriman. 2012 Systematic review of the prevalence of gout and hyperuricaemia in Australia. Intern. Med. 42:997–1007.
   Web of Science ®Google Scholar
• Roddy, E., and M. Doherty. 2010. Gout. Epidemiology of gout. Arthritis Res. Ther. 12:223.
   PubMed Web of Science ®Google Scholar
• Roozbeh, J., M. M. Sagheb, and E. Vafaie 2015.The association between blood pressure level and serum uric acid concentration in hemodialysis patients. J. Nephropathol. 4:85.
   PubMedGoogle Scholar
• Rummun, N., J. Somanah, S. Ramsaha, T. Bahorun, and V. S. Neergheen-Bhujun. 2013. Bioactivity of nonedible parts of Punica granatum L.: a potential source of functional ingredients. Int. J. Food Sci. 2013:1–12.
   Google Scholar
• Sarvaiya, V. N., K. A. Sadariya, P. G. Pancha, A. M. Thaker, A. C. Patel, and A. S. Prajapati. 2015. Evaluation of antigout activity of Phyllanthus emblica fruit extracts on potassium oxonate-induced gout rat model. Vet. World. 8:1230–1236.
   PubMed Web of Science ®Google Scholar
• Schaffer, S., G. Eckert, S. Schmitt-Schillig, and W. Müller 2006. Local Mediterranean Food Plants and Nutraceuticals, pp-86–115. Karger Publishers. 59.
   Google Scholar
• Seyed, M. A., I. Jantan, S. N. A. Bukhari, and K. Vijayaraghavan. 2016. A comprehensive review on the chemotherapeutic potential of piceatannol for cancer treatment, with mechanistic insights. J. Agric. Food. Chem. 64:725–737.
   PubMed Web of Science ®Google Scholar
• Sharma, K., N. Mahato, S. H. Nile, E. T. Lee, and Y. R. Lee. 2016. Economical and environmentally-friendly approaches for usage of onion (Allium cepa L.) waste. Food Funct. 7:3354–3369.
   PubMed Web of Science ®Google Scholar
• Shipley, M. 2011. Hyperuricaemia and gout. J.R. Coll. Physicians Edinb. 41:229–333.
   PubMedGoogle Scholar
• Shishodia, S., and B. B. Aggarwal 2006. Resveratrol: a polyphenol for all seasons. Oxidative Stress Dise. 20:1.
   Google Scholar
• Soobrattee, M. A., V. S. Neergheen, A. Luximon-Ramma, O. I. Aruoma, and T. Bahorun. 2005. Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutat. Res. Fundam. Mol. Mech. Mutagen. 579:200–213.
   PubMed Web of Science ®Google Scholar
• Sturge, R. A., J. T. Scott, A. C. Kennedy, D. P. Hart, and W. W. Buchanan 1977. Serum uric acid in England and Scotland. Ann Rheum Dis. 36:420–427.
   PubMed Web of Science ®Google Scholar
• Sundy, J. S., H. S. Baraf, R. A. Yood, N. L. Edwards, S. R. Gutierrez-Urena, E. L. Treadwell, J. Vßzquez-Mellado, W. B. White, P. E. Lipsky, Z. Horowitz, and W. Huang. 2011. Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials. Jama. 306:711–720.
   PubMed Web of Science ®Google Scholar
• Touhami, M., A. Laroubi, K. Elhabazi, F. Loubna, I. Zrara, Y. Eljahiri, A. Oussama, F. Grases, and A. Chait. 2007. Lemon juice has protective activity in a rat urolithiasis model. BMC Urol. 7:18.
   PubMedGoogle Scholar
• Trifiro, G., P. Morabito, L. Cavagna, C. Ferrajolo, S. Pecchioli, M. Simonetti, and M. Mazzaglia 2013. Epidemiology of gout and hyperuricaemia in Italy during the years 2005–2009: a nationwide population-based study. Ann. Rheum. Dis. 72:694–700.
   PubMed Web of Science ®Google Scholar
• Uaratanawong, S., S. Suraamornkul, S. Angkeaw, and R. Uaratanawong. 2011. Prevalence of hyperuricemia in Bangkok population. Clin. Rheumatol. 30:887–893.
   PubMed Web of Science ®Google Scholar
• Ullah, M. F. 2017. Anti-oxidative and xanthine oxidase inhibitory activities and phytochemical screening of the hydro-alcoholic extract of mace, aril of Myristica fragrans: Implication as an adjuvant therapy in gout. Int. J. Food Prop. 20:694–703.
   Web of Science ®Google Scholar
• Umamaheswari, M., A. Madeswaran, and K. Asokkumar. 2013. Virtual screening analysis and in-vitro xanthine oxidase inhibitory activity of some commercially available flavonoids. Iran. J. Pharm. Res. 12:317.
   PubMed Web of Science ®Google Scholar
• Van Hoorn, D. E., R. J. Nijveldt, P. A. Van Leeuwen, Z. Hofman, L. M'Rabet, D. B. De Bont, and K. Van Norren. 2002. Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids. Eur. J. Pharmacol. 451:111–118.
   PubMed Web of Science ®Google Scholar
• Vayalil, P. K. 2012. Date fruits (Phoenix dactylifera Linn): an emerging medicinal food. Crit. Rev. Food Sci. Nutr. 52:249–271.
   PubMed Web of Science ®Google Scholar
• Vulić, J. J., T. N. Ćebović, J. M. Čanadanović-Brunet, G. S. Ćetković, V. M. Čanadanović, S. M. Djilas, and V. T. T. Šaponjac. 2014. In-vivo and in-vitro antioxidant effects of beetroot pomace extracts. J. Funct. Foods. 6:168–175.
   Web of Science ®Google Scholar
• Wang, C. P., Y. Wang, X. Wang, X. Zhang, J. F. Ye, L. S. Hu, and L. D. Kong. 2011. Mulberroside A possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Planta Med. 77:786–794.
   PubMed Web of Science ®Google Scholar
• Wang, H., L. Cheng, D. Lin, Z. Ma, and X. Deng 2017a. Lemon fruits lower the blood uric acid levels in humans and mice. Sci. Hortic. 220:4–10.
   Web of Science ®Google Scholar
• Wang, J., R. P. Chen, L. Lei, Q. Q. Song, R. Y. Zhang, Y. B. Li, C. Yang, S. D. Lin, L. S. Chen, and Y. L. Wang. 2013. Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China. Asia Pac. J. Clin. Nutr. 22:590–598.
   PubMed Web of Science ®Google Scholar
• Wang, X., M. Zhao, G. Su, M. Cai, D. Sun‐Waterhouse, C. Zhou, and L. Lin. 2016. Anti-hyperuricemic activities of an ethanolic and aqueous extract of walnut (Juglans regia L.) shell and a new aldehyde xanthine oxidase inhibitor. Int. J. Food Sci. Technol. 51:453–460.
   Web of Science ®Google Scholar
• Wang, X., M. Zhao, G. Su, M. Cai, C. Zhou, J. Huang, and L. Lin. 2015b. The antioxidant activities and the xanthine oxidase inhibition effects of walnut (Juglans regia L.) fruit, stem and leaf. Int. J. Food Sci. Technol. 50:233–239.
   Web of Science ®Google Scholar
• Wang, Y., Z. Lin, B. Zhang, A. Nie, and M. Bian. 2017c. Cichorium intybus L. promotes intestinal uric acid excretion by modulating ABCG2 in experimental hyperuricemia. Nutr. Metab. 14:38.
   Google Scholar
• Wang, Y., G. Zhang, J. Pan, and D. Gong. 2015d. Novel insights into the inhibitory mechanism of kaempferol on xanthine oxidase. J. Agric. Food. Chem. 63:526–534.
   PubMed Web of Science ®Google Scholar
• Wang, Y., J. X. Zhu, L. D. Kong, C. Yang, C. H. K. Cheng, and X. Zhang. 2004. Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate‐treated mice. Basic Clin. Pharmacol. Toxicol. 94:232–237.
   PubMed Web of Science ®Google Scholar
• Wang, Z. H., C. C. Hsu, and M. C. Yin. 2009. Anti-oxidative characteristics of aqueous and ethanol extracts of glossy privet fruit. Food Chem. 112:914–918.
   Web of Science ®Google Scholar
• Wang, Z., S. H. Kwon, S. H. Hwang, Y.-H. Kang, J. Y. Lee, and S. S. Lim. 2017e Competitive binding experiments can reduce the false positive results of affinity-based ultrafiltration-HPLC: A case study for identification of potent xanthine oxidase inhibitors from Perilla frutescens extract. J. Chromatogr. B. 1048:30–37.
   PubMed Web of Science ®Google Scholar
• Williams, R. J., J. P. Spencer, and C. Rice-Evans. 2004. Flavonoids: antioxidants or signalling molecules? Free Radic. Biol. Med. 36:838–849.
   PubMed Web of Science ®Google Scholar
• Wong, R. C. N. Y.P., S. P. Chuah, R. Y. Koh, and A. P. K. Ling. 2014. Antioxidant and xanthine oxidase inhibitory activities of Swietenia macrophylla and Punica granatum. International conference on biological, environment and food Engineering. August 4–5.
   Google Scholar
• Yan, J., G. Zhang, Y. Hu, and Y. Ma 2013. Effect of luteolin on xanthine oxidase: Inhibition kinetics and interaction mechanism merging with docking simulation. Food Chem. 141:3766–3773.
   PubMed Web of Science ®Google Scholar
• Yano, H., Y. Tamura, K. Kobayashi, M. Tanemoto, and S. Uchida. 2014. Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease. Clin. Exp. Nephrol. 18:50–55.
   PubMed Web of Science ®Google Scholar
• Yi, L. T., J. Li, D. X. Su, J. F. Dong, and C. F. Li. 2012. Hypouricemic effect of the methanol extract from Prunus mume fruit in mice. Pharm. Biol. 50:1423–1427.
   PubMed Web of Science ®Google Scholar
• You, L., A. Liu, G. Wuyun, H. Wu, and P. Wang. 2014. Prevalence of hyperuricemia and the relationship between serum uric acid and metabolic syndrome in the Asian Mongolian area. J. Atheroscler Thromb. 21:355–365.
   PubMed Web of Science ®Google Scholar
• Zalokar, J., J. Lellouch, J. R. Claude, and D. Kuntz. 1972. Serum uric acid in 23,923 men and gout in a subsample of 4257 men in France. J. Chronic Dis. 25:305–312.
   PubMedGoogle Scholar
• Zgaga, L., E. Theodoratou, J. Kyle, S. M. Farrington, F. Agakov, A. Tenesa, M. Walker, G. McNeill, A. F. Wright, and I. Rudan. 2012. The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study. PloS One. 7:e38123.
   PubMed Web of Science ®Google Scholar
• Zhang, C., G. Zhang, J. Pan, and D. Gong. 2016. Galangin competitively inhibits xanthine oxidase by aping-pong mechanism. Food Res. Int. 89:152–160.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., T. Neogi, C. Chen, C. Chaisson, D. J. Hunter, and H. K. Choi. 2012. Cherry consumption and decreased risk of recurrent gout attacks. Arthritis Rheumatol. 64:4004–4011.
   PubMed Web of Science ®Google Scholar
• Zhang, Z. C., H. B. Wang, Q. Zhou, B. Hu, J. H. Wen, and J. L. Zhang. 2017. Screening of effective xanthine oxidase inhibitors in dietary anthocyanins from purple sweet potato (Ipomoea batatas L. Cultivar Eshu No. 8) and deciphering of the underlying mechanisms in-vitro. J. Funct. Foods. 36:102–111.
   Web of Science ®Google Scholar
• Zhang, Z. C., G. H. Su, C. L. Luo, Y. L. Pang, L. Wang, X. Li, J. H. Wen, and J. L. Zhang. 2015. Effects of anthocyanins from purple sweet potato (Ipomoea batatas L. cultivar Eshu No. 8) on the serum uric acid level and xanthine oxidase activity in hyperuricemic mice. Food Funct. 6:3045–3055.
   PubMed Web of Science ®Google Scholar
• Zhao, M., D. Zhu, D. Sun-Waterhouse, G. Su, L. Lin, X. Wang, and Y. Dong. 2014. In-vitro and in-vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects. J. Agric. Food. Chem. 62:7771–7778.
   PubMed Web of Science ®Google Scholar
• Zhao, R., D. Chen, and H. Wu. 2017. Pu-erh ripened tea resists to hyperuricemia through xanthine oxidase and renal urate transporters in hyperuricemic mice. J. Funct Food. 29:201–207.
   Web of Science ®Google Scholar
• Zhao, X., J. X. Zhu, S. F. Mo, Y. Pan, and L. D. Kong. 2006. Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. J. Ethnopharmacol. 103:357–365.
   PubMed Web of Science ®Google Scholar
• Zhu, Y., B. J. Pandya, and H. K. Choi. 2011. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007–2008. Arthritis Rheumatol. 63:3136–3141.
   PubMed Web of Science ®Google Scholar