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Rethinking the impact of RG-I mainly from fruits and vegetables on dietary health

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References

  • Abboud, K. Y., B. B. da Luz, J. L. Dallazen, M. F. d. P. Werner, C. B. B. Cazarin, M. R. Maróstica Junior, M. Iacomini, and L. M. C. Cordeiro. 2019. Gastroprotective effect of soluble dietary fibres from yellow passion fruit (Passiflora edulis f. flavicarpa) peel against ethanol-induced ulcer in rats. Journal of Functional Foods 54:552–8. doi: 10.1016/j.jff.2019.02.003.
  • Abdel-Massih, R. M., E. A. Baydoun, K. W. Waldron, and C. T. Brett. 2007. Effects of partial enzymic degradation of sugar beet pectin on oxidative coupling of pectin-linked ferulates in vitro. Phytochemistry 68 (13):1785–90. doi: 10.1016/j.phytochem.2007.04.007.
  • Adami, E. R., C. R. Corso, N. M. Turin-Oliveira, C. M. Galindo, L. Milani, M. C. Stipp, G. E. do Nascimento, A. Chequin, L. M. da Silva, and S. F. de Andrade. 2018. Antineoplastic effect of pectic polysaccharides from green sweet pepper (Capsicum annuum) on mammary tumor cells in vivo and in vitro. Carbohydrate Polymers 201:280–92. doi: 10.1016/j.carbpol.2018.08.071.
  • Aggarwal, P., and K. S. Sandhu. 2004. Effect of hydrocolloids on the quality of Kinnow squash. Journal of Food Science Technology 41 (2):149–54.
  • Ai, L., Y. C. Chung, S. Y. Lin, K. C. Lee, P. F. H. Lai, Y. Xia, G. Wang, and S. W. Cui. 2018. Active pectin fragments of high in vitro antiproliferation activities toward human Colon adenocarcinoma cells: Rhamnogalacturonan II. Food Hydrocolloids 83:239–45. doi: 10.1016/j.foodhyd.2018.05.017.
  • Alancay, M. M., M. O. Lobo, C. M. Quinzio, and L. B. Iturriaga. 2017. Extraction and physicochemical characterization of pectin from tomato processing waste. Journal of Food Measurement and Characterization 11 (4):2119–30. doi: 10.1007/s11694-017-9596-0.
  • Aspinall, G. O., I. W. Cottrell, S. V. Egan, M. Morrison, and J. N. C. Whyte. 1967. Polysaccharides of soy-beans. Part IV. Partial hydrolysis of the acidic polysaccharide complex from cotyledon meal. Journal of the Chemical Society C: Organic:1071–80. doi: 10.1039/j39670001071.
  • Aspinall, G. O., B. Gestetner, J. A. Molloy, and M. Uddin. 1968. Pectic substances from Lucerne (Medicago sativa). Part II. Acidic oligosaccharides from partial hydrolysis of leaf and stem pectic acids. Journal of the Chemical Society C: Organic:2554–9. doi: 10.1039/j39680002554.
  • Babbar, N., W. Dejonghe, M. Gatti, S. Sforza, and K. Elst. 2016. Pectic oligosaccharides from agricultural by-products: production, characterization and health benefits. Critical Reviews in Biotechnology 36 (4):594–606. doi: 10.3109/07388551.2014.996732.
  • Barbieri, S. F., S. da Costa Amaral, A. C. Ruthes, C. L. de Oliveira Petkowicz, N. C. Kerkhoven, E. R. A. da Silva, and J. L. M. Silveira. 2019. Pectins from the pulp of gabiroba (Campomanesia xanthocarpa Berg): Structural characterization and rheological behavior. Carbohydrate Polymers 214:250–8. doi: 10.1016/j.carbpol.2019.03.045.
  • Benítez, V., E. Mollá, M. A. Martín-Cabrejas, Y. Aguilera, and R. M. Esteban. 2017. Physicochemical properties and in vitro antidiabetic potential of fibre concentrates from onion by-products. Journal of Functional Foods 36:34–42. doi: 10.1016/j.jff.2017.06.045.
  • Bianchi, F., N. Larsen, T. de Mello Tieghi, M. A. T. Adorno, W. Kot, S. M. I. Saad, L. Jespersen, and K. Sivieri. 2018. Modulation of gut microbiota from obese individuals by in vitro fermentation of citrus pectin in combination with Bifidobacterium longum BB-46. Applied Microbiology and Biotechnology 102 (20):8827–40. doi: 10.1007/s00253-018-9234-8.
  • Birch, P. R. J., G. Bryan, B. Fenton, E. M. Gilroy, I. Hein, J. T. Jones, A. Prashar, M. A. Taylor, L. Torrance, and I. K. Toth. 2012. Crops that feed the world 8: Potato: are the trends of increased global production sustainable? Food Security 4 (4):477–508. doi: 10.1007/s12571-012-0220-1.
  • Broxterman, S. E., and H. A. Schols. 2018. Characterisation of pectin-xylan complexes in tomato primary plant cell walls. Carbohydrate Polymers 197:269–76. doi: 10.1016/j.carbpol.2018.06.003.
  • Cai, D., Y. Yao, Y. Tang, Z. Wang, W. Shi, W. Huang, and K. Ding. 2017. A concise synthesis of three branches derived from polysaccharide RN1 and anti-Pancreatic cancer activity study. Polymers 9 (12):536–10. (doi: 10.3390/polym9100536.
  • Cantu-Jungles, T. M., D. Maria-Ferreira, L. M. da Silva, C. H. Baggio, M. F. Werner, M. Iacomini, T. R. Cipriani, and L. M. Cordeiro. 2014. Polysaccharides from prunes: gastroprotective activity and structural elucidation of bioactive pectins. Food Chemistry 146:492–9. doi: 10.1016/j.foodchem.2013.09.093.
  • Cao, J., D. Tang, Y. Wang, X. Li, L. Hong, and C. Sun. 2018. Characteristics and immune-enhancing activity of pectic polysaccharides from sweet cherry (Prunus avium). Food Chemistry 254:47–54. doi: 10.1016/j.foodchem.2018.01.145.
  • Cardenas-Fernandez, M., C. Hamley-Bennett, D. J. Leak, and G. J. Lye. 2018. Continuous enzymatic hydrolysis of sugar beet pectin and l-arabinose recovery within an integrated biorefinery. Bioresource Technology 269:195–202. doi: 10.1016/j.biortech.2018.08.069.
  • Caroline, C. K., G. R. Healey, W. J. Kelly, M. L. Patchett, Z. Jordens, G. W. Tannock, I. M. Sims, T. J. Bell, D. Hedderley, and B. Henrissat. 2019. Genomic insights from Monoglobus pectinilyticus: a pectin-degrading specialist bacterium in the human Colon. The International Society for Microbial Ecology Journal 13:1437–56. doi: 10.1038/s41396-019-0363-6.
  • Cartmell, A., E. C. Lowe, A. Baslé, S. J. Firbank, D. A. Ndeh, H. Murray, N. Terrapon, V. Lombard, B. Henrissat, J. E. Turnbull, et al. 2017. How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. Proceedings of the National Academy of Sciences 114 (27):7037–42. doi: 10.1073/pnas.1704367114.
  • Chattopadhyay, N., G. Nosál’ová, S. Saha, S. S. Bandyopadhyay, D. Flešková, and B. Ray. 2011. Structural features and antitussive activity of water extracted polysaccharide from Adhatoda vasica. Carbohydrate Polymers 83 (4):1970–4. doi: 10.1016/j.carbpol.2010.11.002.
  • Chen, J., H. Cheng, D. Wu, R. J. Linhardt, Z. Zhi, L. Yan, S. Chen, and X. Ye. 2017. Green recovery of pectic polysaccharides from citrus canning processing water. Journal of Cleaner Production 144:459–69. doi: 10.1016/j.jclepro.2016.12.140.
  • Chen, H., H. Jiao, Y. Cheng, K. Xu, X. Jia, Q. Shi, S. Guo, M. Wang, L. Du, and F. Wang. 2016. In vitro and in vivo immunomodulatory activity of okra (Abelmoschus esculentus L.) polysaccharides. Journal of Medicinal Food 19 (3):253–65. doi: 10.1089/jmf.2015.3513.
  • Chen, J., R. H. Liang, W. Liu, T. Li, C. M. Liu, S. S. Wu, and Z. J. Wang. 2013. Pectic-oligosaccharides prepared by dynamic high-pressure microfluidization and their in vitro fermentation properties. Carbohydrate Polymers 91 (1):175–82. doi: 10.1016/j.carbpol.2012.08.021.
  • Chen, L., J. Liu, Y. Zhang, B. Dai, Y. An, and L. L. Yu. 2015. Structural, thermal, and anti-inflammatory properties of a novel pectic polysaccharide from alfalfa (Medicago sativa L.) stem. Journal of Agricultural and Food Chemistry 63 (12):3219–28. doi: 10.1021/acs.jafc.5b00494.
  • Chen, J., W. Pang, Y. Kan, L. Zhao, Z. He, W. Shi, B. Yan, H. Chen, and J. Hu. 2018. Structure of a pectic polysaccharide from Pseudostellaria heterophylla and stimulating insulin secretion of INS-1 cell and distributing in rats by oral. International Journal of Biological Macromolecules 106:456–63. doi: 10.1016/j.ijbiomac.2017.08.034.
  • Chen, G., M. Xie, P. Wan, D. Chen, H. Ye, L. Chen, X. Zeng, and Z. Liu. 2018. Digestion under saliva, simulated gastric and small intestinal conditions and fermentation in vitro by human intestinal microbiota of polysaccharides from Fuzhuan brick tea. Food Chemistry 244:331–9. doi: 10.1016/j.foodchem.2017.10.074.
  • Chen, L., Y. Zhou, Z. He, Q. Liu, S. Lai, and H. Yang. 2018. Effect of exogenous ATP on the postharvest properties and pectin degradation of mung bean sprouts (Vigna radiata). Food Chemistry 251:9–17. doi: 10.1016/j.foodchem.2018.01.061.
  • Chen, Q., L. Zhu, Y. Tang, Z. Zhao, T. Yi, and H. Chen. 2017. Preparation-related structural diversity and medical potential in the treatment of diabetes mellitus with ginseng pectins. Annals of the New York Academy of Sciences 1401 (1):75–89. doi: 10.1111/nyas.13424.
  • Cheng, K., H. Sorek, H. Zimmermann, D. E. Wemmer, and M. Pauly. 2013. Solution-state 2D NMR spectroscopy of plant cell walls enabled by a dimethylsulfoxide-d6/1-ethyl-3-methylimidazolium acetate solvent. Analytical Chemistry 85 (6):3213–21. doi: 10.1021/ac303529v.
  • Cho, E. H., H. T. Jung, B. H. Lee, H. S. Kim, J. K. Rhee, and S. H. Yoo. 2019. Green process development for apple-peel pectin production by organic acid extraction. Carbohydrate Polymers 204:97–103. doi: 10.1016/j.carbpol.2018.09.086.
  • Chung, W. S. F., M. Meijerink, B. Zeuner, J. Holck, P. Louis, A. S. Meyer, J. M. Wells, H. J. Flint, and S. H. Duncan. 2017. Prebiotic potential of pectin and pectic oligosaccharides to promote anti-inflammatory commensal bacteria in the human Colon. FEMS Microbiology Ecology 93 (11):1–9. doi: 10.1093/femsec/fix127.
  • Colodel, C., L. C. Vriesmann, R. F. Teofilo, and C. L. de Oliveira Petkowicz. 2018. Extraction of pectin from ponkan (Citrus reticulata Blanco cv. Ponkan) peel: Optimization and structural characterization. International Journal of Biological Macromolecules 117:385–91. doi: 10.1016/j.ijbiomac.2018.05.048.
  • Conti, S., A. Vexler, L. Hagoel, L. Kalich-Philosoph, B. W. Corn, N. Honig, N. Shtraus, Y. Meir, I. Ron, I. Eliaz, and S. Lev-Ari. 2018. Modified citrus pectin as a potential sensitizer for radiotherapy in prostate cancer. Integrative Cancer Therapies 17 (4):1225–34. doi: 10.1177/1534735418790382.
  • Conway, T., and P. S. Cohen. 2015. Commensal and pathogenic Escherichia coli metabolism in the gut. Microbiol Spectrum 3 (3):343–62.
  • Cornuault, V., S. Pose, and J. P. Knox. 2018. Disentangling pectic homogalacturonan and rhamnogalacturonan-I polysaccharides: Evidence for Sub-populations in fruit parenchyma systems. Food Chemistry 246:275–85. doi: 10.1016/j.foodchem.2017.11.025.
  • Correa-Ferreira, M. L., D. M. Ferreira, J. L. Dallazen, A. M. S. Silva, M. F. P. Werner, and C. L. O. Petkowicz. 2018. Gastroprotective effects and structural characterization of a pectic fraction isolated from Artemisia campestris subsp maritima. International Journal of Biological Macromolecules 107:2395–403. doi: 10.1016/j.ijbiomac.2017.10.127.
  • Cosgrove, D. J. 2014. Re-constructing our models of cellulose and primary cell wall assembly. Current Opinion in Plant Biology 22:122–31. doi: 10.1016/j.pbi.2014.11.001.
  • Cui, S. W., and Y. H. Chang. 2014. Emulsifying and structural properties of pectin enzymatically extracted from pumpkin. LWT - Food Science and Technology 58 (2):396–403. doi: 10.1016/j.lwt.2014.04.012.
  • Cui, L., J. Wang, R. Huang, Y. Tan, F. Zhang, Y. Zhou, and L. Sun. 2019. Analysis of pectin from Panax ginseng flower buds and their binding activities to galectin-3. International Journal of Biological Macromolecules 128:459–67. doi: 10.1016/j.ijbiomac.2019.01.129.
  • Dange, M. C., N. Srinivasan, S. K. More, S. M. Bane, A. Upadhya, A. D. Ingle, R. P. Gude, R. Mukhopadhyaya, and R. D. Kalraiya. 2014. Galectin-3 expressed on different lung compartments promotes organ specific metastasis by facilitating arrest, extravasation and organ colonization via high affinity ligands on melanoma cells. Clinical & Experimental Metastasis 31 (6):661–73. doi: 10.1007/s10585-014-9657-2.
  • Desai, M. S., A. M. Seekatz, N. M. Koropatkin, N. Kamada, C. A. Hickey, M. Wolter, N. A. Pudlo, S. Kitamoto, N. Terrapon, A. Muller, et al. 2016. A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility. Cell 167 (5):1339–53. doi: 10.1016/j.cell.2016.10.043.
  • Ding, Q., S. Nie, J. Hu, X. Zong, Q. Li, and M. Xie. 2017. In vitro and in vivo gastrointestinal digestion and fermentation of the polysaccharide from Ganoderma atrum. Food Hydrocolloids 63:646–55. doi: 10.1016/j.foodhyd.2016.10.018.
  • Ding, Y., Y. Yan, Y. Peng, D. Chen, J. Mi, L. Lu, Q. Luo, X. Li, X. Zeng, and Y. Cao. 2019. In vitro digestion under simulated saliva, gastric and small intestinal conditions and fermentation by human gut microbiota of polysaccharides from the fruits of Lycium barbarum. International Journal of Biological Macromolecules 125:751–60. doi: 10.1016/j.ijbiomac.2018.12.081.
  • Dong, Q., X. Liu, J. Yao, X. Dong, C. Ma, Y. Xu, J. Fang, and K. Ding. 2010. Structural characterization of a pectic polysaccharide from Nerium indicum flowers. Phytochemistry 71 (11–12):1430–7. doi: 10.1016/j.phytochem.2010.05.019.
  • Duan, J., V. L. Chen, Q. Dong, K. Ding, and J. Fang. 2010. Chemical structure and immunoinhibitory activity of a pectic polysaccharide containing glucuronic acid from the leaves of Diospyros kaki. International Journal of Biological Macromolecules 46 (5):465–70. doi: 10.1016/j.ijbiomac.2010.03.014.
  • Elst, K., N. Babbar, S. Van Roy, S. Baldassarre, W. Dejonghe, M. Maesen, and S. Sforza. 2018. Continuous production of pectic oligosaccharides from sugar beet pulp in a cross flow continuous enzyme membrane reactor. Bioprocess and Biosystems Engineering 41 (11):1717–29. doi: 10.1007/s00449-018-1995-z.
  • Eriksson, D., U. Carlson-Nilsson, R. Ortíz, and E. Andreasson. 2016. Overview and breeding strategies of table potato production in Sweden and the Fennoscandian region. Potato Research 59 (3):279–94. doi: 10.1007/s11540-016-9328-6.
  • Fan, Y., L. Sun, S. Yang, C. He, G. Tai, and Y. Zhou. 2018. The roles and mechanisms of homogalacturonan and rhamnogalacturonan I pectins on the inhibition of cell migration. International Journal of Biological Macromolecules 106:207–17. doi: 10.1016/j.ijbiomac.2017.08.004.
  • Fernandez, M. L., E. C. K. Lin, A. Trejo, and D. J. McNamara. 1994. Prickly pear (Opuntia sp.) pectin alters hepatic cholesterol metabolism without affecting cholesterol absorption in Guinea pigs fed a hypercholesterolemic diet. The Journal of Nutrition 124 (6):817–24. doi: 10.1093/jn/124.6.817.
  • Fernandez, M. L., A. Trejo, and D. J. McNamara. 1990. Pectin isolated from prickly pear (Opuntia sp.) modifies low density lipoprotein metabolism in Cholesterol-Fed Guinea pigs. The Journal of Nutrition 120 (11):1283–90. doi: 10.1093/jn/120.11.1283.
  • Ferrari, S., D. V. Savatin, F. Sicilia, G. Gramegna, F. Cervone, and G. D. Lorenzo. 2013. Oligogalacturonides: plant damage-associated molecular patterns and regulators of growth and development. Frontiers in Plant Science 4:49. doi: 10.3389/fpls.2013.00049.
  • Ferreira-Lazarte, A., F. J. Moreno, C. Cueva, I. Gil-Sanchez, and M. Villamiel. 2019. Behaviour of citrus pectin during its gastrointestinal digestion and fermentation in a dynamic simulator (simgi(R)). Carbohydrate Polymers 207:382–90. doi: 10.1016/j.carbpol.2018.11.088.
  • Fishman, M. L., H. K. Chau, A. T. Hotchkiss, A. White, R. A. Garcia, and P. H. Cooke. 2019. Effect of long term cold storage and microwave extraction time on the physical and chemical properties of citrus pectin. Food Hydrocolloids 92:104–16. doi: 10.1016/j.foodhyd.2018.12.047.
  • Gao, H., W. Zhang, B. Wang, A. Hui, B. Du, T. Wang, L. Meng, H. Bian, and Z. Wu. 2018. Purification, characterization and anti-fatigue activity of polysaccharide fractions from okra (Abelmoschus esculentus (L.) Moench). Food & Function 9 (2):1088–101. doi: 10.1039/C7FO01821E.
  • Gao, X., Y. Zhi, L. Sun, X. Peng, T. Zhang, H. Xue, G. Tai, and Y. Zhou. 2013. The inhibitory effects of a rhamnogalacturonan I (RG-I) domain from ginseng pectin on galectin-3 and its structure-activity relationship. Journal of Biological Chemistry 288 (47):33953–65. doi: 10.1074/jbc.M113.482315.
  • Georgiev, Y. N., B. S. Paulsen, H. Kiyohara, M. Ciz, M. H. Ognyanov, O. Vasicek, F. Rise, P. N. Denev, A. Lojek, T. G. Batsalova, et al. 2017. Tilia tomentosa pectins exhibit dual mode of action on phagocytes as beta-glucuronic acid monomers are abundant in their rhamnogalacturonans I. Carbohydrate Polymers 175:178–91. doi: 10.1016/j.carbpol.2017.07.073.
  • Gibson, G. R., R. Hutkins, M. E. Sanders, S. L. Prescott, R. A. Reimer, S. J. Salminen, K. Scott, C. Stanton, K. S. Swanson, and P. D. Cani. 2017. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology 14 (8):491–502. doi: 10.1038/nrgastro.2017.75.
  • Golovchenko, V. V., D. S. Khramova, R. G. Ovodova, A. S. Shashkov, and Y. S. Ovodov. 2012. Structure of pectic polysaccharides isolated from onion Allium cepa L. using a simulated gastric medium and their effect on intestinal absorption. Food Chemistry 134 (4):1813–22. doi: 10.1016/j.foodchem.2012.03.087.
  • Grassino, A. N., M. Brncic, D. Vikic-Topic, S. Roca, M. Dent, and S. R. Brncic. 2016. Ultrasound assisted extraction and characterization of pectin from tomato waste. Food Chemistry 198:93–100. doi: 10.1016/j.foodchem.2015.11.095.
  • Guillon, F., A. Moise, B. Quemener, B. Bouchet, M. F. Devaux, C. Alvarado, and M. Lahaye. 2017. Remodeling of pectin and hemicelluloses in tomato pericarp during fruit growth. Plant Science 257:48–62. doi: 10.1016/j.plantsci.2017.01.008.
  • Gullon, B., G. Garrote, J. L. Alonso, and J. C. Parajo. 2007. Production of L-lactic acid and oligomeric compounds from apple pomace by simultaneous saccharification and fermentation: a response surface methodology assessment. Journal of Agricultural and Food Chemistry 55 (14):5580–7. doi: 10.1021/jf070442v.
  • Guo, L., H. Tao, B. Cui, and S. Janaswamy. 2019. The effects of sequential enzyme modifications on structural and physicochemical properties of sweet potato starch granules. Food Chemistry 277:504–14. doi: 10.1016/j.foodchem.2018.11.014.
  • Han, K., C. Jin, H. Chen, P. Wang, M. Yu, and K. Ding. 2018. Structural characterization and anti-A549 lung cancer cells bioactivity of a polysaccharide from Houttuynia cordata. International Journal of Biological Macromolecules 120 (Pt A):288–96. doi: 10.1016/j.ijbiomac.2018.08.061.
  • Harsha, M. R., S. V. C. Prakash, and S. M. Dharmesh. 2016. Modified pectic polysaccharide from turmeric (Curcuma longa): a potent dietary component against gastric ulcer. Carbohydrate Polymers 138:143–55. doi: 10.1016/j.carbpol.2015.11.043.
  • Heusschen, R., A. W. Griffioen, and V. L. Thijssen. 2013. Galectin-9 in tumor biology: a jack of multiple trades. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1836 (1):177–85. doi: 10.1016/j.bbcan.2013.04.006.
  • Ho, G. T., Y. F. Zou, H. Wangensteen, and H. Barsett. 2016. RG-I regions from elderflower pectins substituted on GalA are strong immunomodulators. International Journal of Biological Macromolecules 92:731–8. doi: 10.1016/j.ijbiomac.2016.07.090.
  • Hosseini, S. S., F. Khodaiyan, M. Kazemi, and Z. Najari. 2019. Optimization and characterization of pectin extracted from sour orange peel by ultrasound assisted method. International Journal of Biological Macromolecules 125:621–9. doi: 10.1016/j.ijbiomac.2018.12.096.
  • Houben, K., R. P. Jolie, I. Fraeye, A. M. Van Loey, and M. E. Hendrickx. 2011. Comparative study of the cell wall composition of broccoli, carrot, and tomato: structural characterization of the extractable pectins and hemicelluloses. Carbohydrate Research 346 (9):1105–11. doi: 10.1016/j.carres.2011.04.014.
  • Huang, C., X. Cao, X. Chen, Y. Fu, Y. Zhu, Z. Chen, Q. Luo, L. Li, X. Song, and R. Jia. 2017. A pectic polysaccharide from Ligusticum chuanxiong promotes intestine antioxidant defense in aged mice. Carbohydrate Polymers 174:915–22. doi: 10.1016/j.carbpol.2017.06.122.
  • Huang, J. H., R. Jiang, A. Kortstee, D. C. Dees, L. M. Trindade, H. Gruppen, and H. A. Schols. 2017. Transgenic modification of potato pectic polysaccharides also affects type and level of cell wall xyloglucan. Journal of the Science of Food and Agriculture 97 (10):3240–8. doi: 10.1002/jsfa.8172.
  • Ibarrola, J., V. Arrieta, R. Sadaba, E. Martinez-Martinez, A. Garcia-Pena, V. Alvarez, A. Fernandez-Celis, A. Gainza, E. Santamaria, and J. Fernandez-Irigoyen. 2018. Galectin-3 down-regulates antioxidant peroxiredoxin-4 in human cardiac fibroblasts: a new pathway to induce cardiac damage. Clinical Science 132 (13):1471–85. doi: 10.1042/CS20171389.
  • Jiang, Y., and J. Du. 2017. Properties of high-methoxyl pectin extracted from “Fuji” apple pomace in China. Journal of Food Process Engineering 40 (3):e12497. doi: 10.1111/jfpe.12497.
  • Jiao, L., X. Zhang, M. Wang, B. Li, Z. Liu, and S. Liu. 2014. Chemical and antihyperglycemic activity changes of ginseng pectin induced by heat processing. Carbohydrate Polymers 114:567–73. doi: 10.1016/j.carbpol.2014.08.018.
  • Jouini, M., A. Abdelhamid, M. A. Chaouch, D. Le Cerf, A. Bouraoui, H. Majdoub, and H. Ben Jannet. 2018. Physico-chemical characterization and pharmacological activities of polysaccharides from Opuntia microdasys var. rufida cladodes. International Journal of Biological Macromolecules 107:1330–8. doi: 10.1016/j.ijbiomac.2017.10.003.
  • Kapoor, S., and S. M. Dharmesh. 2017. Pectic Oligosaccharide from tomato exhibiting anticancer potential on a gastric cancer cell line: Structure-function relationship. Carbohydrate Polymers 160:52–61. doi: 10.1016/j.carbpol.2016.12.046.
  • Karnik, D., J. Jung, S. Hawking, and L. Wicker. 2016. Sugar beet pectin fractionated using isopropanol differs in galacturonic acid, protein, ferulic acid and surface hydrophobicity. Food Hydrocolloids 60:179–85. doi: 10.1016/j.foodhyd.2016.03.037.
  • Kaya, M., A. G. Sousa, M. J. Crepeau, S. O. Sorensen, and M. C. Ralet. 2014. Characterization of citrus pectin samples extracted under different conditions: influence of acid type and pH of extraction. Annals of Botany 114 (6):1319–26. doi: 10.1093/aob/mcu150.
  • Kazemi, M., F. Khodaiyan, and S. S. Hosseini. 2019. Utilization of food processing wastes of eggplant as a high potential pectin source and characterization of extracted pectin. Food Chemistry 294:339–46. doi: 10.1016/j.foodchem.2019.05.063.
  • Kazemi, M., F. Khodaiyan, M. Labbafi, S. Saeid Hosseini, and M. Hojjati. 2019. Pistachio green hull pectin: Optimization of microwave-assisted extraction and evaluation of its physicochemical, structural and functional properties. Food Chemistry 271:663–72. doi: 10.1016/j.foodchem.2018.07.212.
  • Khodaei, N., B. Fernandez, I. Fliss, and S. Karboune. 2016. Digestibility and prebiotic properties of potato rhamnogalacturonan I polysaccharide and its galactose-rich oligosaccharides/oligomers. Carbohydrate Polymers 136:1074–84. doi: 10.1016/j.carbpol.2015.09.106.
  • Khodaei, N., and S. Karboune. 2013. Extraction and structural characterisation of rhamnogalacturonan I-type pectic polysaccharides from potato cell wall. Food Chemistry 139 (1–4):617–23. doi: 10.1016/j.foodchem.2013.01.110.
  • Khodaei, N., and S. Karboune. 2016. Enzymatic generation of galactose-rich oligosaccharides/oligomers from potato rhamnogalacturonan I pectic polysaccharides. Food Chemistry 197:406–14. doi: 10.1016/j.foodchem.2015.10.122.
  • Klosterhoff, R. R., L. K. S. Kanazawa, A. Furlanetto, J. V. C. Peixoto, C. R. Corso, E. R. Adami, M. Iacomini, R. T. H. Fogaca, A. Acco, S. Cadena, et al. 2018. Anti-fatigue activity of an arabinan-rich pectin from acerola (Malpighia emarginata). International Journal of Biological Macromolecules 109:1147–53. doi: 10.1016/j.ijbiomac.2017.11.105.
  • Komalavilas, P., and A. J. Mort. 1989. The acetylation of O-3 of galacturonic acid in the rhamnose-rich portion of pectins. Carbohydrate Research 189:261–72. doi: 10.1016/0008-6215(89)84102-3.
  • Koropatkin, N. M., E. A. Cameron, and E. C. Martens. 2012. How glycan metabolism shapes the human gut microbiota. Nature Reviews Microbiology 10 (5):323–35. doi: 10.1038/nrmicro2746.
  • Kostalova, Z., and Z. Hromadkova. 2019. Structural characterisation of polysaccharides from roasted hazelnut skins. Food Chemistry 286:179–84.
  • Košťálová, Z., M. Aguedo, and Z. Hromádková. 2016. Microwave-assisted extraction of pectin from unutilized pumpkin biomass. Chemical Engineering and Processing: Process Intensification 102:9–15. doi: 10.1016/j.cep.2015.12.009.
  • Košťálová, Z., Z. Hromadkova, and A. Ebringerova. 2013. Structural diversity of pectins isolated from the Styrian oil-pumpkin (Cucurbita pepo var. styriaca) fruit. Carbohydrate Polymers 93 (1):163–71. doi: 10.1016/j.carbpol.2012.05.017.
  • Kpodo, F. M., J. K. Agbenorhevi, K. Alba, R. J. Bingham, I. N. Oduro, G. A. Morris, and V. Kontogiorgos. 2017. Pectin isolation and characterization from six okra genotypes. Food Hydrocolloids 72:323–30. doi: 10.1016/j.foodhyd.2017.06.014.
  • Kumar, A., and G. S. Chauhan. 2010. Extraction and characterization of pectin from apple pomace and its evaluation as lipase (steapsin) inhibitor. Carbohydrate Polymers 82 (2):454–9. doi: 10.1016/j.carbpol.2010.05.001.
  • Laaf, D., P. Bojarová, L. Elling, and V. Křen. 2019. Galectin-carbohydrate interactions in biomedicine and biotechnology. Trends in Biotechnology 37 (4):402–15. doi: 10.1016/j.tibtech.2018.10.001.
  • Lama-Muñoz, A., G. Rodríguez-Gutiérrez, F. Rubio-Senent, and J. Fernández-Bolaños. 2012. Production, characterization and isolation of neutral and pectic oligosaccharides with low molecular weights from olive by-products thermally treated. Food Hydrocolloids 28 (1):92–104. doi: 10.1016/j.foodhyd.2011.11.008.
  • Le Normand, M., H. Melida, B. Holmbom, T. E. Michaelsen, M. Inngjerdingen, V. Bulone, B. S. Paulsen, and M. Ek. 2014. Hot-water extracts from the inner bark of Norway spruce with immunomodulating activities. Carbohydrate Polymers 101:699–704. doi: 10.1016/j.carbpol.2013.09.067.
  • Li, X., Y. Dong, Y. Guo, Z. Zhang, L. Jia, H. Gao, Z. Xing, and F. Duan. 2019. Okra polysaccharides reduced the gelling-required sucrose content in its synergistic gel with high-methoxyl pectin by microphase separation effect. Food Hydrocolloids 95:506–16. doi: 10.1016/j.foodhyd.2019.04.069.
  • Li, T., S. Li, L. Du, N. Wang, M. Guo, J. Zhang, F. Yan, and H. Zhang. 2010. Effects of haw pectic oligosaccharide on lipid metabolism and oxidative stress in experimental hyperlipidemia mice induced by high-fat diet. Food Chemistry 121 (4):1010–3. doi: 10.1016/j.foodchem.2010.01.039.
  • Li, S., S. Li, X. Hao, Y. Zhang, and W. Deng. 2019. Perindopril and a galectin-3 inhibitor improve ischemic heart failure in rabbits by reducing gal-3 expression and myocardial fibrosis. Frontiers in Physiology 10:267. doi: 10.3389/fphys.2019.00267.
  • Li, T., Y. Liu, Y. Dong, S. Li, and R. Zhu. 2014. Anti-fat deposition and antioxidant effects of haw pectic oligosaccharide in the liver of high-fat-fed mice. CyTA - Journal of Food 12 (1):27–31. doi: 10.1080/19476337.2013.783625.
  • Li, S., M. Li, H. Yue, L. Zhou, L. Huang, Z. Du, and K. Ding. 2018. Structural elucidation of a pectic polysaccharide from Fructus Mori and its bioactivity on intestinal bacteria strains. Carbohydrate Polymers 186:168–75. doi: 10.1016/j.carbpol.2018.01.026.
  • Lin, L., P. Wang, Z. Du, W. Wang, Q. Cong, C. Zheng, C. Jin, K. Ding, and C. Shao. 2016. Structural elucidation of a pectin from flowers of Lonicera japonica and its antipancreatic cancer activity. International Journal of Biological Macromolecules 88:130–7. doi: 10.1016/j.ijbiomac.2016.03.025.
  • Liu, Z., F. Pi, X. Guo, X. Guo, and S. Yu. 2019. Characterization of the structural and emulsifying properties of sugar beet pectins obtained by sequential extraction. Food Hydrocolloids 88:31–42. doi: 10.1016/j.foodhyd.2018.09.036.
  • Liu, J., Y. Zhao, Q. Wu, A. John, Y. Jiang, J. Yang, H. Liu, and B. Yang. 2018. Structure characterisation of polysaccharides in vegetable “okra” and evaluation of hypoglycemic activity. Food Chemistry 242:211–6. doi: 10.1016/j.foodchem.2017.09.051.
  • Li, H. Y., S. Yang, J. C. Li, and J. X. Feng. 2018. Galectin 3 inhibition attenuates renal injury progression in cisplatin-induced nephrotoxicity. Bioscience Reports 38 (6):BSR20181803. doi: 10.1042/BSR20181803.
  • Li, S., G. Yang, J. Yan, D. Wu, Y. Hou, Q. Diao, and Y. Zhou. 2018. Polysaccharide structure and immunological relationships of RG-I pectin from the bee pollen of Nelumbo nucifera. International Journal of Biological Macromolecules 111:660–6. doi: 10.1016/j.ijbiomac.2018.01.015.
  • Li, K., L. Zhu, H. Li, Y. Zhu, C. Pan, X. Gao, and W. Liu. 2019. Structural characterization and rheological properties of a pectin with anti-constipation activity from the roots of Arctium lappa L. Carbohydrate Polymers 215:119–29. doi: 10.1016/j.carbpol.2019.03.051.
  • Li, W. J., Z. G. Fan, Y. Y. Wu, Z. G. Jiang, and R. C. Shi. 2019. Eco-friendly extraction and physicochemical properties of pectin from jackfruit peel waste with subcritical water. Journal of the Science of Food and Agriculture 99 (12):5283–5292. doi: 10.1002/jsfa.9729.
  • Lopez-Siles, M., T. M. Khan, S. H. Duncan, H. J. Harmsen, L. J. Garcia-Gil, and H. J. Flint. 2012. Cultured representatives of two major phylogroups of human colonic Faecalibacterium prausnitzii can utilize pectin, uronic acids, and host-derived substrates for growth. Applied and Environmental Microbiology 78 (2):420–8. doi: 10.1128/AEM.06858-11.
  • Luis, A. S., J. Briggs, X. Zhang, B. Farnell, D. Ndeh, A. Labourel, A. Baslé, A. Cartmell, N. Terrapon, K. Stott, et al. 2018. Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides. Nature Microbiology 3 (2):210–9. doi: 10.1038/s41564-017-0079-1.
  • Luo, H., B. Liu, L. Zhao, J. He, T. Li, L. Zha, X. Li, Q. Qi, Y. Liu, and Z. Yu. 2017. Galectin-3 mediates pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension. Journal of the American Society of Hypertension 11 (10):673–83. doi: 10.1016/j.jash.2017.07.009.
  • Mallikarjuna, S. E., and S. M. Dharmesh. 2018. Swallow root (Decalepis hamiltonii) pectic oligosaccharide (SRO1) induces cancer cell death via modulation of galectin-3 and survivin. Carbohydrate Polymers 186:402–10. doi: 10.1016/j.carbpol.2018.01.053.
  • Maltby, R., M. P. Leatham-Jensen, T. Gibson, P. S. Cohen, and T. Conway. 2013. Nutritional basis for colonization resistance by human commensal Escherichia coli strains HS and Nissle 1917 against E. coli O157:H7 in the mouse intestine. PLos One 8 (1):e53957. doi: 10.1371/journal.pone.0053957.
  • Manjegowda, S. B., H. M. Rajagopal, and S. M. Dharmesh. 2017. Polysaccharide of black cumin (Nigella sativa) modulates molecular signaling Cascade of gastric ulcer pathogenesis. International Journal of Biological Macromolecules 101:823–36. doi: 10.1016/j.ijbiomac.2017.03.093.
  • Margolles, A., and C. G. de los Reyes-Gavilan. 2003. Purification and functional characterization of a novel alpha-L-arabinofuranosidase from Bifidobacterium longum B667. Applied and Environmental Microbiology 69 (9):5096–103. doi: 10.1128/AEM.69.9.5096-5103.2003.
  • Maria-Ferreira, D., L. M. da Silva, D. A. G. B. Mendes, D. de Almeida Cabrini, A. M. Nascimento, M. Lacomini, T. R. Cipriani, A. R. S. Santos, M. F. de Paula Werner, and C. H. Baggio. 2018. Rhamnogalacturonan from Acmella oleracea (L.) R.K. Jansen: Gastroprotective and ulcer healing properties in rats. PLos One 9 (1):e84762. doi: 10.1371/journal.pone.0084762.
  • Martens, E. C., E. C. Lowe, H. Chiang, N. A. Pudlo, M. Wu, N. P. McNulty, D. W. Abbott, B. Henrissat, H. J. Gilbert, D. N. Bolam, et al. 2011. Recognition and degradation of plant cell wall polysaccharides by two human gut symbionts. PLos Biology 9 (12):e1001221. doi: 10.1371/journal.pbio.1001221.
  • Martinez-Guryn, K., N. Hubert, K. Frazier, S. Urlass, M. W. Musch, P. Ojeda, J. F. Pierre, J. Miyoshi, T. J. Sontag, C. M. Cham, et al. 2018. Small intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids. Cell Host & Microbe 23 (4):458–69. doi: 10.1016/j.chom.2018.03.011.
  • Martinez-Martinez, E., N. Lopez-Andres, R. Jurado-Lopez, E. Rousseau, M. V. Bartolome, A. Fernandez-Celis, P. Rossignol, F. Islas, A. Antequera, S. Prieto, et al. 2015. Galectin-3 participates in cardiovascular remodeling associated with obesity. Hypertension 66 (5):961–9. doi: 10.1161/HYPERTENSIONAHA.115.06032.
  • Martínez-Romero, D., F. Guillén, S. Castillo, P. J. Zapata, D. Valero, and M. Serrano. 2009. Effect of ethylene concentration on quality parameters of fresh tomatoes stored using a carbon-heat hybrid ethylene scrubber. Postharvest Biology and Technology 51 (2):206–11. doi: 10.1016/j.postharvbio.2008.07.011.
  • Maxwell, E. G., I. J. Colquhoun, H. K. Chau, A. T. Hotchkiss, K. W. Waldron, V. J. Morris, and N. J. Belshaw. 2015. Rhamnogalacturonan I containing homogalacturonan inhibits Colon cancer cell proliferation by decreasing ICAM1 expression. Carbohydrate Polymers 132:546–53. doi: 10.1016/j.carbpol.2015.06.082.
  • Mcneil, M., A. G. Darvill, and P. Albersheim. 1980. Structure of plant cell walls: X. Rhamnogalacturonan I, a structurally complex pectic polysaccharide in the walls of suspension-cultured sycamore cells. Plant Physiology 66 (6):1128–34. doi: 10.1104/pp.66.6.1128.
  • Mcneil, M., A. G. Darvill, and P. Albersheim. 1982. Structure of plant cell walls: XII. Indetification of seven differently linked glycosyl residues attached to O-4 of the 2,4-linked L-rhamnosyl residues of rhamnogalaturonan I. Plant Physiology 70 (6):1586–91. doi: 10.1104/pp.70.6.1586.
  • Meijerink, M., C. Rosch, N. Taverne, K. Venema, H. Gruppen, H. A. Schols, and J. M. Wells. 2018. Structure Dependent-Immunomodulation by sugar beet arabinans via a SYK tyrosine Kinase-Dependent signaling pathway. Frontiers in Immunology 9:1972. doi: 10.3389/fimmu.2018.01972.
  • Meldrum, O. W., G. E. Yakubov, G. Gartaula, M. A. McGuckin, and M. J. Gidley. 2017. Mucoadhesive functionality of cell wall structures from fruits and grains: Electrostatic and polymer network interactions mediated by soluble dietary polysaccharides. Scientific Report 7 (1):15794.
  • Miao, M., H. Jiang, B. Jiang, S. W. Cui, Z. Jin, and T. Zhang. 2012. Functional characteristics of starches from the root of Cynanchum auriculatum Royle ex Wight grown in China. Carbohydrate Polymers 88 (2):568–75. doi: 10.1016/j.carbpol.2011.12.044.
  • Mohan, M., and K. K. Elyas. 2019. Anti-hyperglycemic properties of a purified proteinaceous protease inhibitor from macrotyloma uniflorum seeds. Current Topics in Medicinal Chemistry 18 (29):2502–10. doi: 10.2174/1568026619666181220110038.
  • Morales-Contreras, B. E., W. Rosas-Flores, J. C. Contreras-Esquivel, L. Wicker, and J. Morales-Castro. 2018. Pectin from husk tomato (Physalis ixocarpa Brot.): Rheological behavior at different extraction conditions. Carbohydrate Polymers 179:282–9. doi: 10.1016/j.carbpol.2017.09.097.
  • Motherway, M. O., G. F. Fitzgerald, and D. Van Sinderen. 2011. Metabolism of a plant derived galactose-containing polysaccharide by Bifidobacterium breve UCC2003. Microbial Biotechnology 4 (3):403–16. doi: 10.1111/j.1751-7915.2010.00218.x.
  • Namir, M., H. Siliha, and M. F. Ramadan. 2015. Fiber pectin from tomato pomace: characteristics, functional properties and application in low-fat beef burger. Journal of Food Measurement and Characterization 9 (3):305–12. doi: 10.1007/s11694-015-9236-5.
  • Ng, J. K., R. Schroder, D. A. Brummell, P. W. Sutherland, I. C. Hallett, B. G. Smith, L. D. Melton, and J. W. Johnston. 2015. Lower cell wall pectin solubilisation and galactose loss during early fruit development in apple (Malus x domestica) cultivar 'scifresh' are associated with slower softening rate. Journal of Plant Physiology 176:129–37. doi: 10.1016/j.jplph.2014.12.012.
  • Niu, J., Z. Pi, H. Yue, Y. Wang, Q. Yu, and S. Liu. 2012. Effect of ginseng polysaccharide on the urinary excretion of type 2 diabetic rats studied by liquid chromatography-mass spectrometry. Journal of Chromatography B 907:7–12. doi: 10.1016/j.jchromb.2012.08.012.
  • Obro, J., J. Harholt, H. V. Scheller, and C. Orfila. 2004. Rhamnogalacturonan I in Solanum tuberosum tubers contains complex arabinogalactan structures. Phytochemistry 65 (10):1429–38. doi: 10.1016/j.phytochem.2004.05.002.
  • Ognyanov, M., C. Remoroza, H. A. Schols, Y. Georgiev, M. Kratchanova, and C. Kratchanov. 2016. Isolation and structure elucidation of pectic polysaccharide from rose hip fruits (Rosa canina L.). Carbohydrate Polymers 151:803–11. doi: 10.1016/j.carbpol.2016.06.031.
  • Ohtsubo, K., M. Z. Chen, J. M. Olefsky, and J. D. Marth. 2011. Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. Nature Medicine 17 (9):1067–75. doi: 10.1038/nm.2414.
  • Oosterveld, A., I. E. Pol, G. Beldman, and A. G. J. Voragen. 2001. Isolation of feruloylated arabinans and rhamnogalacturonans from sugar beet pulp and their gel forming ability by oxidative cross-linking. Carbohydrate Polymers 44 (1):9–17. doi: 10.1016/S0144-8617(00)00193-4.
  • Pacheco, M. T., M. Villamiel, R. Moreno, and F. J. Moreno. 2019. Structural and rheological properties of pectins extracted from industrial sugar beet by-Products. Molecules 24 (3):392. doi: 10.3390/molecules24030392.
  • Park, H. R., S. B. Park, H. D. Hong, H. J. Suh, and K. S. Shin. 2017. Structural elucidation of anti-metastatic rhamnogalacturonan II from the pectinase digest of citrus peels (Citrus unshiu). International Journal of Biological Macromolecules 94:161–9. doi: 10.1016/j.ijbiomac.2016.09.100.
  • Phyo, P., T. Wang, C. Xiao, C. T. Anderson, and M. Hong. 2017. Effects of pectin molecular weight changes on the structure, dynamics, and polysaccharide interactions of primary cell walls of Arabidopsis thaliana: Insights from Solid-State NMR. Biomacromolecules 18 (9):2937–50. doi: 10.1021/acs.biomac.7b00888.
  • Pi, F., Z. Liu, X. Guo, X. Guo, and H. Meng. 2019. Chicory root pulp pectin as an emulsifier as compared to sugar beet pectin. Part 1: Influence of structure, concentration, counterion concentration. Food Hydrocolloids 89:792–801. doi: 10.1016/j.foodhyd.2018.11.061.
  • Prabasari, I., F. Pettolino, M.-L. Liao, and A. Bacic. 2011. Pectic polysaccharides from mature orange (Citrus sinensis) fruit albedo cell walls: Sequential extraction and chemical characterization. Carbohydrate Polymers 84 (1):484–94. doi: 10.1016/j.carbpol.2010.12.012.
  • Prado, S., G. F. Ferreira, Y. Harazono, T. M. Shiga, A. Raz, N. C. Carpita, and J. P. Fabi. 2017. Ripening-induced chemical modifications of papaya pectin inhibit cancer cell proliferation. Scientific Report 7 (1):16564.
  • Ralet, M. C., M. J. Crepeau, J. Vigouroux, J. Tran, A. Berger, C. Salle, F. Granier, L. Botran, and H. M. North. 2016. Xylans provide the structural driving force for mucilage adhesion to the Arabidopsis seed coat. Plant Physiology 171 (1):165–78. doi: 10.1104/pp.16.00211.
  • Ramasubbu, N., V. Paloth, Y. Luo, G. D. Brayer, and M. J. Levine. 1996. Structure of human salivary a-Amylase at 1.6 a resolution: Implications for its role in the oral cavity. Acta Crystallographica Section D Biological Crystallography 52 (3):435–46. doi: 10.1107/S0907444995014119.
  • Ridley, B. L., M. A. O’Neill, and D. Mohnen. 2001. Pectins: Structure, biosynthesis, and oligogalacturonide-related signaling. Phytochemistry 57 (6):929–67. doi: 10.1016/S0031-9422(01)00113-3.
  • Rosenbaum, M., R. Knight, and R. L. Leibel. 2015. The gut microbiota in human energy homeostasis and obesity. Trends in Endocrinology and Metabolism: TEM 26 (9):493–501. doi: 10.1016/j.tem.2015.07.002.
  • Santiago, J. S. J., Z. Jamsazzadeh Kermani, F. Xu, A. M. Van Loey, and M. E. Hendrickx. 2017. The effect of high pressure homogenization and endogenous pectin-related enzymes on tomato purée consistency and serum pectin structure. Innovative Food Science & Emerging Technologies 43:35–44. doi: 10.1016/j.ifset.2017.07.028.
  • Schols, H. A., E. J. Bakx, D. Schipper, and A. G. J. Voragen. 1995. A xylogalacturonan subunit present in the modified hairy regions of apple pectin. Carbohydrate Research 279:265–79. doi: 10.1016/0008-6215(95)00287-1.
  • Shakhmatov, E. G., E. N. Makarova, and V. A. Belyy. 2019. Structural studies of biologically active pectin-containing polysaccharides of pomegranate. Punica granatum. International Journal of Biological Macromolecules 122:29–36. doi: 10.1016/j.ijbiomac.2018.10.146.
  • Sheng, X., J. Yan, Y. Meng, Y. Kang, Z. Han, G. Tai, Y. Zhou, and H. Cheng. 2017. Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology. Food & Function 8 (3):1020–7. doi: 10.1039/C7FO00071E.
  • Sheridan, P. O., J. C. Martin, T. D. Lawley, H. P. Browne, H. M. Harris, A. Bernalier-Donadille, S. H. Duncan, P. W. O'Toole, K. P. Scott, and H. J. Flint. 2016. Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic. Firmicutes. Microbial Genomics 2 (2):1–16. doi: 10.1099/mgen.0.000043.
  • Shi, H., L. Yu, Y. Shi, J. Lu, H. Teng, Y. Zhou, and L. Sun. 2017. Structural characterization of a Rhamnogalacturonan I domain from ginseng and its inhibitory effect on galectin-3. Molecules 22 (6):1016. (doi: 10.3390/molecules22061016.
  • Silva, I., R. M. F. Sousa, A. Oliveira, W. J. Oliveira, L. A. C. Motta, D. Pasquini, and H. Otaguro. 2018. Polymeric blends of hydrocolloid from chia seeds/apple pectin with potential antioxidant for food packaging applications. Carbohydrate Polymers 202:203–10. doi: 10.1016/j.carbpol.2018.08.061.
  • Sims, I. M., A. M. Smith, G. A. Morris, M. U. Ghori, and S. M. Carnachan. 2018. Structural and rheological studies of a polysaccharide mucilage from lacebark leaves (Hoheria populnea A. Cunn.). International Journal of Biological Macromolecules 111:839–47. doi: 10.1016/j.ijbiomac.2017.12.142.
  • Slavov, A., H. Kiyohara, and H. Yamada. 2013. Immunomodulating pectic polysaccharides from waste rose petals of Rosa damascena Mill. International Journal of Biological Macromolecules 59:192–200. doi: 10.1016/j.ijbiomac.2013.04.054.
  • Sousa, A. G., H. L. Nielsen, I. Armagan, J. Larsen, and S. O. Sørensen. 2015. The impact of rhamnogalacturonan-I side chain monosaccharides on the rheological properties of citrus pectin. Food Hydrocolloids 47:130–9. doi: 10.1016/j.foodhyd.2015.01.013.
  • Stoltze Gaborit, F., H. Bosselmann, C. Kistorp, K. Iversen, T. Kumler, F. Gustafsson, J. P. Goetze, G. Soletormos, N. Tonder, and M. Schou. 2016. Galectin 3: association to neurohumoral activity, echocardiographic parameters and renal function in outpatients with heart failure. BMC Cardiovascular Disorders 16 (1):117. doi: 10.1186/s12872-016-0290-7.
  • Strasser, G. R., and R. Amado. 2001. Pectic substances from red beet (Beta vulgaris conditiva). Part I. Structural analysis of rhamnogalacturonan I using enzymic degradation and methylation analysis. Carbohydrate Polymers 44 (1):63–70. doi: 10.1016/S0144-8617(00)00190-9.
  • Sun, C., Y. Chen, X. Li, G. Tai, Y. Fan, and Y. Zhou. 2014. Anti-hyperglycemic and anti-oxidative activities of ginseng polysaccharides in STZ-induced diabetic mice. Food & Function 5 (5):845–8. doi: 10.1039/c3fo60326a.
  • Sun, L., D. Ropartz, L. Cui, H. Shi, M. C. Ralet, and Y. Zhou. 2019. Structural characterization of rhamnogalacturonan domains from Panax ginseng C. A. Meyer. Carbohydrate Polymers 203:119–27. doi: 10.1016/j.carbpol.2018.09.045.
  • Talmadge, K. W., K. Keegstra, W. D. Bauer, and P. Albersheim. 1973. The structure of plant cell walls: I. The macromolecular components of the walls of suspension-cultured sycamore cells with a detailed analysis of the pectic polysaccharides. Plant Physiology 51 (1):158–73. doi: 10.1104/pp.51.1.158.
  • Tan, L., S. Eberhard, S. Pattathil, C. Warder, J. Glushka, C. Yuan, Z. Hao, X. Zhu, U. Avci, J. S. Miller, et al. 2013. An Arabidopsis cell wall proteoglycan consists of pectin and arabinoxylan covalently linked to an arabinogalactan protein. The Plant Cell 25 (1):270–87. doi: 10.1105/tpc.112.107334.
  • Torkova, A. A., K. V. Lisitskaya, I. S. Filimonov, O. A. Glazunova, G. S. Kachalova, V. N. Golubev, and T. V. Fedorova. 2018. Physicochemical and functional properties of Cucurbita maxima pumpkin pectin and commercial citrus and apple pectins: a comparative evaluation. PLos One 13 (9):e0204261. doi: 10.1371/journal.pone.0204261.
  • Tvete Inngjerdingen, K., N. Ballo, B. Z. Zhang, K. E. Malterud, T. E. Michaelsen, D. Diallo, and B. S. Paulsen. 2013. A comparison of bioactive aqueous extracts and polysaccharide fractions from roots of wild and cultivated Cochlospermum tinctorium A. Rich. Phytochemistry 93:136–43. doi: 10.1016/j.phytochem.2013.03.012.
  • Ulvskov, P., H. Wium, D. Bruce, B. JorRgensen, K. B. Qvist, M. SkjoT, D. Hepworth, B. Borkhardt, and S. O. SorRensen. 2005. Biophysical consequences of remodeling the neutral side chains of rhamnogalacturonan I in tubers of transgenic potatoes. Planta 220 (4):609–20. doi: 10.1007/s00425-004-1373-8.
  • Valdés, A., N. Burgos, A. Jiménez, and M. Garrigós. 2015. Natural pectin polysaccharides as edible coatings. Coatings 5 (4):865–86. doi: 10.3390/coatings5040865.
  • Van Laere, K. M., R. Hartemink, M. Bosveld, H. A. Schols, and A. G. Voragen. 2000. Fermentation of plant cell wall derived polysaccharides and their corresponding oligosaccharides by intestinal bacteria. Journal of Agricultural and Food Chemistry 48 (5):1644–52. doi: 10.1021/jf990519i.
  • Vayssade, M., N. Sengkhamparn, R. Verhoef, C. Delaigue, O. Goundiam, P. Vigneron, A. G. Voragen, H. A. Schols, and M. D. Nagel. 2010. Antiproliferative and proapoptotic actions of okra pectin on B16F10 melanoma cells. Phytotherapy Research 24 (7):982–9. doi: 10.1002/ptr.3040.
  • Venkateshaiah, S. U., M. S. Eswaraiah, H. N. Annaiah, and S. M. Dharmesh. 2017. Antimetastatic pectic polysaccharide from Decalepis hamiltonii: galectin-3 inhibition and immune-modulation. Clinical & Experimental Metastasis 34 (2):141–54. doi: 10.1007/s10585-017-9836-z.
  • Vincken, J. P., H. A. Schols, R. J. F. J. Oomen, M. C. McCann, P. Ulvskov, A. G. J. Voragen, and R. G. F. Visser. 2003. If homogalacturonan were a side chain of Rhamnogalaturonan I. Implications for cell wall architecture. Plant Physiology 132 (4):1781–9. doi: 10.1104/pp.103.022350.
  • Voragen, A. G. J., G. J. Coenen, R. P. Verhoef, and H. A. Schols. 2009. Pectin, a versatile polysaccharide present in plant cell walls. Structural Chemistry 20 (2):263–75. doi: 10.1007/s11224-009-9442-z.
  • Wang, C., W. Li, Z. Chen, X. Gao, G. Yuan, Y. Pan, and H. Chen. 2018. Effects of simulated gastrointestinal digestion in vitro on the chemical properties, antioxidant activity, alpha-amylase and alpha-glucosidase inhibitory activity of polysaccharides from Inonotus obliquus. Food Research International 103:280–8. doi: 10.1016/j.foodres.2017.10.058.
  • Wang, L., F. Liu, A. Wang, Z. Yu, Y. Xu, and Y. Yang. 2017. Purification, characterization and bioactivity determination of a novel polysaccharide from pumpkin (Cucurbita moschata) seeds. Food Hydrocolloids 66:357–64. doi: 10.1016/j.foodhyd.2016.12.003.
  • Wang, T., Y. B. Park, D. J. Cosgrove, and M. Hong. 2015. Cellulose-pectin spatial contacts are inherent to never-dried Arabidopsis primary cell walls: Evidence from solid-state nuclear magnetic resonance. Plant Physiology 168 (3):871–84. doi: 10.1104/pp.15.00665.
  • Wang, W., X. Wu, T. Chantapakul, D. Wang, S. Zhang, X. Ma, T. Ding, X. Ye, and D. Liu. 2017. Acoustic cavitation assisted extraction of pectin from waste grapefruit peels: a green two-stage approach and its general mechanism. Food Research International 102:101. doi: 10.1016/j.foodres.2017.09.087.
  • Wegmann, U., P. Louis, A. Goesmann, B. Henrissat, S. H. Duncan, and H. J. Flint. 2014. Complete genome of a new Firmicutes species belonging to the dominant human colonic microbiota (“Ruminococcus bicirculans”) reveals two chromosomes and a selective capacity to utilize plant glucans. Environmental Microbiology 16 (9):2879–90. doi: 10.1111/1462-2920.12217.
  • Westereng, B., G. J. Coenen, T. E. Michaelsen, A. G. Voragen, A. B. Samuelsen, H. A. Schols, and S. H. Knutsen. 2009. Release and characterization of single side chains of white cabbage pectin and their complement-fixing activity. Molecular Nutrition & Food Research 53 (6):780–9. doi: 10.1002/mnfr.200800199.
  • Wikiera, A., M. Mika, A. Starzyńska-Janiszewska, and B. Stodolak. 2016. Endo-xylanase and endo-cellulase-assisted extraction of pectin from apple pomace. Carbohydrate Polymers 142:199–205. doi: 10.1016/j.carbpol.2016.01.063.
  • Wu, J., M. Chen, S. Shi, H. Wang, N. Li, J. Su, R. Liu, Z. Huang, H. Jin, X. Ji, and S. Wang. 2017. Hypoglycemic effect and mechanism of a pectic polysaccharide with hexenuronic acid from the fruits of Ficus pumila L. in C57BL/KsJ db/db mice. Carbohydrate Polymers 178:209–20. doi: 10.1016/j.carbpol.2017.09.050.
  • Xin, Y., F. Chen, H. Yang, P. Zhang, Y. Deng, and B. Yang. 2010. Morphology, profile and role of chelate-soluble pectin on tomato properties during ripening. Food Chemistry 121 (2):372–80. doi: 10.1016/j.foodchem.2009.12.038.
  • Xu, S. Y., J. P. Liu, X. Huang, L. P. Du, F. L. Shi, R. Dong, X. T. Huang, K. Zheng, Y. Liu, and K. L. Cheong. 2018. Ultrasonic-microwave assisted extraction, characterization and biological activity of pectin from jackfruit peel. LWT-Food Science and Technology 90:577–82. doi: 10.1016/j.lwt.2018.01.007.
  • Xue, H., Z. Zhao, Z. Lin, J. Geng, Y. Guan, C. Song, Y. Zhou, and G. Tai. 2019. Selective effects of ginseng pectins on galectin-3-mediated T cell activation and apoptosis. Carbohydrate Polymers 219:121–9. doi: 10.1016/j.carbpol.2019.05.023.
  • Yang, J. S., T. H. Mu, and M. M. Ma. 2018. Extraction, structure, and emulsifying properties of pectin from potato pulp. Food Chemistry 244:197–205. doi: 10.1016/j.foodchem.2017.10.059.
  • Yang, J. S., T. H. Mu, and M. M. Ma. 2019. Optimization of ultrasound-microwave assisted acid extraction of pectin from potato pulp by response surface methodology and its characterization. Food Chemistry 289:351–9. doi: 10.1016/j.foodchem.2019.03.027.
  • Yao, R., C. Huang, X. Chen, Z. Yin, Y. Fu, L. Li, B. Feng, X. Song, C. He, G. Yue, et al. 2018. Two complement fixing pectic polysaccharides from pedicel of Lycium barbarum L. promote cellular antioxidant defense. International Journal of Biological Macromolecules 112:356–63. doi: 10.1016/j.ijbiomac.2018.01.207.
  • Yapo, B. M. 2009. Pineapple and banana pectins comprise fewer homogalacturonan building blocks with a smaller degree of polymerization as compared with yellow passion fruit and lemon pectins: Implication for gelling properties. Biomacromolecules 10 (4):717–21. doi: 10.1021/bm801490e.
  • Yapo, B. M., P. Lerouge, J. F. Thibault, and M. C. Ralet. 2007. Pectins from citrus peel cell walls contain homogalacturonans homogenous with respect to molar mass, rhamnogalacturonan I and rhamnogalacturonan II. Carbohydrate Polymers 69 (3):426–35. doi: 10.1016/j.carbpol.2006.12.024.
  • You, Q., M. Wan, X. Fang, X. Yin, C. Luo, and X. Zhang. 2019. Optimization of intermittent microwave extraction method for the determination of pectin from pomelo peels. Materials Research Express 6 (6):065405. doi: 10.1088/2053-1591/ab0d4a.
  • Yu, L., X. Zhang, S. Li, X. Liu, L. Sun, H. Liu, J. Iteku, Y. Zhou, and G. Tai. 2010. Rhamnogalacturonan I domains from ginseng pectin. Carbohydrate Polymers 79 (4):811–7. doi: 10.1016/j.carbpol.2009.08.028.
  • Yuan, Q., S. Lin, Y. Fu, X.-R. Nie, W. Liu, Y. Su, Q.-H. Han, L. Zhao, Q. Zhang, D.-R. Lin, et al. 2019. Effects of extraction methods on the physicochemical characteristics and biological activities of polysaccharides from okra (Abelmoschus esculentus). International Journal of Biological Macromolecules 127:178–86. doi: 10.1016/j.ijbiomac.2019.01.042.
  • Yuan, Y., C. Li, Q. Zheng, J. Wu, K. Zhu, X. Shen, and J. Cao. 2019. Effect of simulated gastrointestinal digestion in vitro on the antioxidant activity, molecular weight and microstructure of polysaccharides from a tropical sea cucumber (Holothuria leucospilota). Food Hydrocolloids 89:735–41. doi: 10.1016/j.foodhyd.2018.11.040.
  • Yuan, J.-J., F. Qin, J.-L. Tu, and B. Li. 2017. Preparation, characterization, and antioxidant activity evaluation of liposomes containing water-soluble hydroxytyrosol from olive. Molecules 22 (6):870. doi: 10.3390/molecules22060870.
  • Zeng, H., S. Miao, Y. Zhang, S. Lin, Y. Jian, Y. Tian, and B. Zheng. 2016. Isolation, preliminary structural characterization and hypolipidemic effect of polysaccharide fractions from Fortunella margarita (Lour.) Swingle. Food Hydrocolloids 52:126–36. doi: 10.1016/j.foodhyd.2015.05.028.
  • Zhang, H., J. Chen, J. Li, L. Yan, S. Li, X. Ye, D. Liu, T. Ding, R. J. Linhardt, C. Orfila, and S. Chen. 2018a. Extraction and characterization of RG-I enriched pectic polysaccharides from mandarin citrus peel. Food Hydrocolloids 79:579–86. doi: 10.1016/j.foodhyd.2017.12.002.
  • Zhang, H., J. Chen, J. Li, C. Wei, X. Ye, J. Shi, and S. Chen. 2018b. Pectin from citrus canning wastewater as potential fat replacer in ice cream. Molecules 23 (4):925. doi: 10.3390/molecules23040925.
  • Zhang, T., Y. Lan, Y. Zheng, F. Liu, D. Zhao, K. H. Mayo, Y. Zhou, and G. Tai. 2016. Identification of the bioactive components from pH-modified citrus pectin and their inhibitory effects on galectin-3 function. Food Hydrocolloids 58:113–9. doi: 10.1016/j.foodhyd.2016.02.020.
  • Zhang, B., W. K. Leung, Y. Zou, W. Mabusela, Q. Johnson, T. E. Michaelsen, and B. S. Paulsen. 2014. Immunomodulating polysaccharides from Lessertia frutescens leaves: isolation, characterization and structure activity relationship. Journal of Ethnopharmacology 152 (2):340–8. doi: 10.1016/j.jep.2014.01.017.
  • Zhang, X., S. Li, L. Sun, L. Ji, J. Zhu, Y. Fan, G. Tai, and Y. Zhou. 2012. Further analysis of the structure and immunological activity of an RG-I type pectin from Panax ginseng. Carbohydrate Polymers 89 (2):519–25. doi: 10.1016/j.carbpol.2012.03.039.
  • Zhang, T., M. C. Miller, Y. Zheng, Z. Zhang, H. Xue, D. Zhao, J. Su, K. H. Mayo, Y. Zhou, and G. Tai. 2017. Macromolecular assemblies of complex polysaccharides with galectin-3 and their synergistic effects on function. Biochemical Journal 474 (22):3849–68. doi: 10.1042/BCJ20170143.
  • Zhang, L., X. Ye, T. Ding, X. Sun, Y. Xu, and D. Liu. 2013. Ultrasound effects on the degradation kinetics, structure and rheological properties of apple pectin. Ultrasonic Sonochemistry 20 (1):222–31. doi: 10.1016/j.ultsonch.2012.07.021.
  • Zhang, X., L. Yu, H. Bi, X. Li, W. Ni, H. Han, N. Li, B. Wang, Y. Zhou, and G. Tai. 2009. Total fractionation and characterization of the water-soluble polysaccharides isolated from panax ginseng C. A. Meyer. Carbohydrate Polymers 77 (3):544–52. doi: 10.1016/j.carbpol.2009.01.034.
  • Zhang, Y., Y. Zhang, A. A. Taha, Y. Ying, X. Li, X. Chen, and C. Ma. 2018. Subcritical water extraction of bioactive components from ginseng roots (Panax ginseng C.A. Meyer). Industrial Crops and Products 117:118–27. doi: 10.1016/j.indcrop.2018.02.079.
  • Zhang, L., S. Zhao, S. Lai, F. Chen, and H. Yang. 2018. Combined effects of ultrasound and calcium on the chelate-soluble pectin and quality of strawberries during storage. Carbohydrate Polymers 200:427–35. doi: 10.1016/j.carbpol.2018.08.013.
  • Zhang, T., Y. Zheng, D. Zhao, J. Yan, C. Sun, Y. Zhou, and G. Tai. 2016. Multiple approaches to assess pectin binding to galectin-3. International Journal of Biological Macromolecules 91:994–1001. doi: 10.1016/j.ijbiomac.2016.06.058.
  • Zhao, X. H., L. Qian, D. L. Yin, and Y. Zhou. 2014. Hypolipidemic effect of the polysaccharides extracted from pumpkin by cellulase-assisted method on mice. International Journal of Biological Macromolecules 64:137–8. doi: 10.1016/j.ijbiomac.2013.12.001.
  • Zhao, J., F. Zhang, X. Liu, K. St Ange, A. Zhang, Q. Li, and R. J. Linhardt. 2017. Isolation of a lectin binding rhamnogalacturonan-I containing pectic polysaccharide from pumpkin. Carbohydrate Polymers 163:330–6. doi: 10.1016/j.carbpol.2017.01.067.
  • Zou, Y. F., H. Barsett, G. T. Ho, K. T. Inngjerdingen, D. Diallo, T. E. Michaelsen, and B. S. Paulsen. 2015. Immunomodulating pectins from root bark, stem bark, and leaves of the Malian medicinal tree Terminalia macroptera, structure activity relations. Carbohydrate Research 403:167–73. doi: 10.1016/j.carres.2014.05.004.
  • Zou, Y. F., X. F. Chen, K. E. Malterud, F. Rise, H. Barsett, K. T. Inngjerdingen, T. E. Michaelsen, and B. S. Paulsen. 2014. Structural features and complement fixing activity of polysaccharides from Codonopsis pilosula Nannf. var. modesta L.T.Shen roots. Carbohydrate Polymers 113:420–9. doi: 10.1016/j.carbpol.2014.07.036.
  • Zou, Y.-F., Y.-P. Fu, X.-F. Chen, I. Austarheim, K. T. Inngjerdingen, C. Huang, F.-Y. Lei, X. Song, L. Li, G. Ye, et al. 2017. Polysaccharides with immunomodulating activity from roots of Gentiana crassicaulis. Carbohydrate Polymers 172:306–14. doi: 10.1016/j.carbpol.2017.04.049.
  • Zou, Y. F., B. Z. Zhang, H. Barsett, K. T. Inngjerdingen, D. Diallo, T. E. Michaelsen, and B. S. Paulsen. 2014. Complement fixing polysaccharides from Terminalia macroptera root bark, stem bark and leaves. Molecules 19 (6):7440–58. doi: 10.3390/molecules19067440.

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