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A systematic review and meta-analysis of medium-chain triglycerides effects on acute satiety and food intake

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  • Ades, A. E., G. Lu, and J. P. T. Higgins. 2005. The interpretation of random-effects meta-analysis in decision models. Medical Decision Making 25 (6):646–54. doi:10.1177/0272989X05282643.
  • Bach, A. C., and V. K. Babayan. 1982. Medium-chain triglycerides: An update. American Journal of Clinical Nutrition 36 (5):950–962.
  • Barbera, R.. 2000. Sensations induced by medium and long chain triglycerides: Role of gastric tone and hormones. Gut 46 (1):32–6. doi:10.1136/gut.46.1.32.
  • Batterham, R. L., M. A. Cowley, C. J. Small, H. Herzog, M. A. Cohen, C. L. Dakin, A. M. Wren, A. E. Brynes, M. J. Low, M. A. Ghatei, et al. 2002. Gut hormone pyy3-36 physiologically inhibits food intake. Nature 418 (6898):650–4. doi:10.1038/nature00887.
  • Chambers, L., K. McCrickerd, and M. R. Yeomans. 2015. Optimising foods for satiety. Trends in Food Science & Technology 41 (2):149–60. doi:10.1016/j.tifs.2014.10.007.
  • Clegg, M. E. 2010. Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance. International Journal of Food Sciences and Nutrition 61 (7):653–79. doi:10.3109/09637481003702114.
  • Clegg, M. E. 2017. They say coconut oil can aid weight loss, but can it really? European Journal of Clinical Nutrition 71 (10):1139–43. doi:10.1038/ejcn.2017.86.
  • Clegg, M. E., M. Golsorkhi, and C. J. Henry. 2013. Combined medium-chain triglyceride and chilli feeding increases diet-induced thermogenesis in normal-weight humans. European Journal of Nutrition 52 (6):1579–85. doi:10.1007/s00394-012-0463-9.
  • Clegg, M. E., M. Pratt, O. Markey, A. Shafat, and C. J. K. Henry. 2012. Addition of different fats to a carbohydrate food: Impact on gastric emptying, glycaemic and satiety responses and comparison with in vitro digestion. Food Research International 48 (1):91–7. doi:10.1016/j.foodres.2012.02.019.
  • Cohen, J. 1992. A power primer. Psychological Bulletin 112 (1):155–9. doi:10.1037/0033-2909.112.1.155.
  • Coleman, H., P. Quinn, and M. E. Clegg. 2016. Medium chain triglycerides and conjugated linoleic acids in beverage form increase satiety and reduce food intake in humans. Nutrition Research 36 (6):526–33. doi:10.1016/j.nutres.2016.01.004.
  • Denke, M. A., and S. M. Grundy. 1992. Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins. The American Journal of Clinical Nutrition 56 (5):895–8. doi:10.1093/ajcn/56.5.895.
  • Elrick, H., L. Stimmler, C. J. Hlad, and Y. Arai. 1964. Plasma insulin response to oral and intravenous glucose administration. The Journal of Clinical Endocrinology & Metabolism 24 (10):1076–82. doi:10.1210/jcem-24-10-1076.
  • Feinle, C., T. Rades, B. Otto, and M. Fried. 2001. Fat digestion modulates gastrointestinal sensations induced by gastric distention and duodenal lipid in humans. Gastroenterology 120 (5):1100–1107. doi:10.1053/gast.2001.23232.
  • Feltrin, K. L., T. J. Little, J. H. Meyer, M. Horowitz, T. Rades, J. Wishart, and C. Feinle-Bisset. 2007. Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans. The Journal of Physiology 581 (2):767–77. doi:10.1113/jphysiol.2007.129650.
  • Feltrin, K. L., T. J. Little, J. H. Meyer, M. Horowitz, T. Rades, J. Wishart, and C. Feinle-Bisset. 2008. Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men. The American Journal of Clinical Nutrition 87 (5):1181–87. doi:10.1093/ajcn/87.5.1181.
  • Feltrin, K. L., T. J. Little, J. H. Meyer, M. Horowitz, A. J. P. M. Smout, J. Wishart, A. N. Pilichiewicz, T. Rades, I. M. Chapman, C. Feinle-Bisset, et al. 2004. Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 287 (3):R524–33. doi:10.1152/ajpregu.00039.2004.
  • Feltrin, K. L., M. Patterson, M. A. Ghatei, S. R. Bloom, J. H. Meyer, M. Horowitz, and C. Feinle-Bisset. 2006. Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men. Peptides 27 (7):1638–43. doi:10.1016/j.peptides.2006.01.023.
  • Flint, A., A. Raben, A. K. Ersbøll, J. J. Holst, and A. Astrup. 2001. The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity. International Journal of Obesity 25 (6):781–92. doi:10.1038/sj.ijo.0801627.
  • Franklin, J. C., B. C. Schiele, J. Brozek, and A. Keys. 1948. Observations on human behavior in experimental semi-starvation and rehabilitation. Journal of Clinical Psychology 4 (1):28–45. doi:10.1002/1097-4679(194801)4:1<28::AID-JCLP2270040103>3.0.CO;2-F.
  • French, S. J., C. A. Conlon, S. T. Mutuma, M. Arnold, N. W. Read, G. Meijer, and J. Francis. 2000. The effects of intestinal infusion of long-chain fatty acids on food intake in humans. Gastroenterology 119 (4):943–48. doi:10.1053/gast.2000.18139.
  • Gibbs, J., R. C. Young, and G. P. Smith. 1973. Cholecystokinin elicits satiety in rats with open gastric fistulas. Nature 245 (5424):323–25. doi:10.1038/245323a0.
  • Goedecke, J. H., V. R. Clark, T. D. Noakes, and E. V. Lambert. 2005. The effects of medium-chain triacylglycerol and carbohydrate ingestion on ultra-endurance exercise performance. International Journal of Sport Nutrition and Exercise Metabolism 15 (1):15–27. doi:10.1123/ijsnem.15.1.15.
  • Hetherington, M. M., K. Cunningham, L. Dye, E. L. Gibson, N. T. Gregersen, J. C. G. Halford, C. L. Lawton, A. Lluch, D. J. Mela, H. C. M. Van Trijp, et al. 2013. Potential benefits of satiety to the consumer: Scientific considerations. Nutrition Research Reviews 26 (1):22–38. doi:10.1017/S0954422413000012.
  • Heymsfield, S. B., J. B. Harp, M. L. Reitman, J. W. Beetsch, D. A. Schoeller, N. Erondu, and A. Pietrobelli. 2007. Why do obese patients not lose more weight when treated with low-calorie diets? a mechanistic perspective. The American Journal of Clinical Nutrition 85 (2):346–54. doi:10.1093/ajcn/85.2.346.
  • Higgins, J. P. T., D. G. Altman, P. C. Gotzsche, P. Juni, D. Moher, A. D. Oxman, J. Savovic, K. F. Schulz, L. Weeks, J. A. C. Sterne, Cochrane Bias Methods Group, Cochrane Statistical Methods Group. 2011. The cochrane collaboration’s tool for assessing risk of bias in randomised trials. British Medical Journal 343:d5928–d5928. doi:10.1136/bmj.d5928.
  • Hill, J. O., H. R. Wyatt, and J. C. Peters. 2012. Energy balance and obesity. Circulation 126 (1):126–32. doi:10.1161/CIRCULATIONAHA.111.087213.
  • Jeukendrup, A. E., J. J. Thielen, A. J. Wagenmakers, F. Brouns, and W. H. Saris. 1998. Effect of medium-chain triacylglycerol and carbohydrate ingestion during exercise on substrate utilization and subsequent cycling performance. The American Journal of Clinical Nutrition 67 (3):397–404. doi:10.1093/ajcn/67.3.397.
  • Kinsella, R., T. Maher, and M. E. Clegg. 2017. Coconut oil has less satiating properties than medium chain triglyceride oil. Physiology & Behavior 179:422–26. doi:10.1016/j.physbeh.2017.07.007.
  • Kissileff, H. R., F. X. Pi-Sunyer, J. Thornton, and G. P. Smith. 1981. C-terminal octapeptide of cholecystokinin decreases food intake in man. The American Journal of Clinical Nutrition 34 (2):154–60. doi:10.1093/ajcn/34.2.154.
  • Krotkiewski, M. 2001. Value of VLCD supplementation with medium chain triglycerides. International Journal of Obesity 25 (9):1393–1400. doi:10.1038/sj.ijo.0801682.
  • Laeger, T., C. C. Metges, and B. Kuhla. 2010. Role of β-hydroxybutyric acid in the central regulation of energy balance. Appetite 54 (3):450–455. doi:10.1016/j.appet.2010.04.005.
  • Lindgren, O., R. D. Carr, C. F. Deacon, J. J. Holst, G. Pacini, A. Mari, and B. Ahrén. 2011. Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans. The Journal of Clinical Endocrinology & Metabolism 96 (8):2519–24. doi:10.1210/jc.2011-0266.
  • Maher, T., and M. E. Clegg. 2019. Dietary lipids with potential to affect satiety: Mechanisms and evidence. Critical Reviews in Food Science and Nutrition 59 (10):1619–44. doi:10.1080/10408398.2017.1423277.
  • Marten, B., M. Pfeuffer, and J. Schrezenmeir. 2006. Medium-chain triglycerides. International Dairy Journal 16 (11):1374–1382. doi:10.1016/j.idairyj.2006.06.015.
  • Matzinger, D. 2000. The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans. Gut 46 (5):689–93. doi:10.1136/gut.46.5.689.
  • McLaughlin, J., M. G. Lucà, M. N. Jones, M. D'Amato, G. J. Dockray, and D. G. Thompson. 1999. Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology 116 (1):46–53. doi:10.1016/S0016-5085(99)70227-1.
  • Moher, D., A. Liberati, J. Tetzlaff, D. G. Altman, and the PRISMA Group. 2009. Preferred reporting items for systematic reviews and meta-analyses: The prisma statement (reprinted from annals of internal medicine). Physical Therapy 89 (9):873–80. doi:10.1093/ptj/89.9.873.
  • National Statistics. 2016. Statistics on obesity, physical activity and diet – England, 2016. UK: NHS Digital.
  • Nishi, Y., H. Hiejima, H. Hosoda, H. Kaiya, K. Mori, Y. Fukue, T. Yanase, H. Nawata, K. Kangawa, M. Kojima, et al. 2005. Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin. Endocrinology 146 (5):2255–64. doi:10.1210/en.2004-0695.
  • Page, K. A., A. Williamson, N. Yu, E. C. McNay, J. Dzuira, R. J. McCrimmon, and R. S. Sherwin. 2009. Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia. Diabetes 58 (5):1237–44. doi:10.2337/db08-1557.
  • Perry, B., and Y. Wang. 2012. Appetite regulation and weight control: The role of gut hormones. Nutrition & Diabetes 2:e26. doi:10.1038/nutd.2011.21.
  • Poppitt, S. D., C. M. Strik, A. K. H. MacGibbon, B. H. McArdle, S. C. Budgett, and A.-T. McGill. 2010. Fatty acid chain length, postprandial satiety and food intake in lean men. Physiology & Behavior 101 (1):161–67. doi:10.1016/j.physbeh.2010.04.036.
  • Rizzo, G., U. Masic, J. A. Harrold, J. E. Norton, and J. C. G. Halford. 2016. Coconut and sunflower oil ratios in ice cream influence subsequent food selection and intake. Physiology & Behavior 164:40–46. doi:10.1016/j.physbeh.2016.05.040.
  • Rolls, B. J., N. Gnizak, A. Summerfelt, and L. J. Laster. 1988. Food intake in dieters and nondieters after a liquid meal containing medium-chain triglycerides. The American Journal of Clinical Nutrition 48 (1):66–71. doi:10.1093/ajcn/48.1.66.
  • Rolls, B. J., L. S. Roe, J. S. Meengs, and D. E. Wall. 2004. Increasing the portion size of a sandwich increases energy intake. Journal of the American Dietetic Association 104 (3):367–72. doi:10.1016/j.jada.2003.12.013.
  • Scharrer, E. 1999. Control of food intake by fatty acid oxidation and ketogenesis. Nutrition 15 (9):704–14. doi:10.1016/S0899-9007(99)00125-2.
  • Sterne, J. A. C., M. Egger, and D. Moher. 2011. Addressing reporting biases. In Cochrane handbook for systematic reviews of interventions, ed. J. P. T. Higgins and S. Green, 5.1.0. The Cochrane Collaboration.
  • St-Onge, M.-P., and P. J. H. Jones. 2002. Physiological effects of medium-chain triglycerides: Potential agents in the prevention of obesity. The Journal of Nutrition 132 (3):329–32. doi:10.1093/jn/132.3.329.
  • St-Onge, M.-P., B. Mayrsohn, M. O'Keeffe, H. R. Kissileff, A. R. Choudhury, and B. Laferrère. 2014. Impact of medium and long chain triglycerides consumption on appetite and food intake in overweight men. European Journal of Clinical Nutrition 68 (10):1134–40. doi:10.1038/ejcn.2014.145.
  • Stubbs, R. J., and C. G. Harbron. 1996. Covert manipulation of the ratio of medium- to long-chain triglycerides in isoenergetically dense diets: Effect on food intake in ad libitum feeding men. International Journal of Obesity and Related Metabolic Disorders 20 (5):435–44.
  • Valente, F. X., F. G. Cândido, L. L. Lopes, D. M. Dias, S. D. L. Carvalho, P. F. Pereira, and J. Bressan. 2018. Effects of coconut oil consumption on energy metabolism, cardiometabolic risk markers, and appetitive responses in women with excess body fat. European Journal of Nutrition 57 (4):1627–37. doi:10.1007/s00394-017-1448-5.
  • World Health Organisation. 2018. Obesity and overweight. Accessed March 19, 2020. https://www.who.int/news-room/fact-sheets/detail/obesity-andoverweight.
  • Wren, A. M., C. J. Small, H. L. Ward, K. G. Murphy, C. L. Dakin, S. Taheri, A. R. Kennedy, G. H. Roberts, D. G. A. Morgan, M. A. Ghatei, et al. 2000. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141 (11):4325–28. doi:10.1210/endo.141.11.7873.
  • Wymelbeke, V. V., A. Himaya, J. Louis-Sylvestre, and M. Fantino. 1998. Influence of medium-chain and long-chain triacylglycerols on the control of food intake in men. The American Journal of Clinical Nutrition 68 (2):226–34. doi:10.1093/ajcn/68.2.226.
  • Wymelbeke, V. V., J. Louis-Sylvestre, and M. Fantino. 2001. Substrate oxidation and control of food intake in men after a fat-substitute meal compared with meals supplemented with an isoenergetic load of carbohydrate, long-chain triacylglycerols, or medium-chain triacylglycerols. The American Journal of Clinical Nutrition 74 (5):620–30. doi:10.1093/ajcn/74.5.620.

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