References
- Aharoni, A. , A. P. Giri , S. Deuerlein , F. Griepink , W. J. de Kogel , F. W. Verstappen , H. A. Verhoeven , M. A. Jongsma , W. Schwab , and H. J. Bouwmeester . 2003. Terpenoid metabolism in wild-type and transgenic Arabidopsis plants. The Plant Cell 15 (12):2866–84. doi: https://doi.org/10.1105/tpc.016253.
- Andre, C. M. , S. Legay , A. Deleruelle , N. Nieuwenhuizen , M. Punter , C. Brendolise , J. M. Cooney , M. Lateur , J.-F. Hausman , Y. Larondelle , et al. 2016. Multifunctional oxidosqualene cyclases and cytochrome P450 involved in the biosynthesis of apple fruit triterpenic acids. New Phytologist 211 (4):1279–94. doi: https://doi.org/10.1111/nph.13996.
- Antalick, G. , S. Tempere , K. Suklje , J. Blackman , A. Deloire , G. de Revel , and L. Schmidtke . 2016. 1, 4-cineole: A contributor to Australian Cabernet Sauvignon typicality. Wine & Viticulture Journal 31 (1):24–7.
- Arias-Pérez, I. , S. Ferrero-Del-Teso , M. P. Sáenz-Navajas , P. Fernández-Zurbano , B. Lacau , J. Astraín , C. Barón , V. Ferreira , and A. Escudero . 2020. Some clues about the changes in wine aroma composition associated to the maturation of “neutral” grapes. Food Chemistry 320:126610. doi: https://doi.org/10.1016/j.foodchem.2020.126610.
- Aubourg, S. , A. Lecharny , and J. Bohlmann . 2002. Genomic analysis of the terpenoid synthase (AtTPS) gene family of Arabidopsis thaliana . Molecular Genetics and Genomics 267 (6):730–45. doi: https://doi.org/10.1007/s00438-002-0709-y.
- Balint, G. , and A. G. Reynolds . 2017. Effects of fruit exposure on fruit composition (Abstract). American Journal of Enology and Viticulture 68 (3):310–24. doi: https://doi.org/10.5344/ajev.2017.16094.
- Balusamy, S. R. D. , S. Rahimi , Y. G. Cho , K. Senthil , and D. C. Yang . 2017. Overexpression of geraniol 10-hydroxylase from Panax ginseng conferred enhanced resistance to Pseudomonas syringae in Arabidopsis . Plant Growth Regulation 81 (2):305–16. doi: https://doi.org/10.1007/s10725-016-0207-6.
- Banerjee, A. , and B. Hamberger . 2018. P450s controlling metabolic bifurcations in plant terpene specialized metabolism. Phytochemistry Reviews 17 (1):81–111. doi: https://doi.org/10.1007/s11101-017-9530-4.
- Baron, M. , B. Prusova , L. Tomaskova , M. Kumsta , and J. Sochor . 2017. Terpene content of wine from the aromatic grape variety ‘Irsai Oliver’ (Vitis vinifera L.) depends on maceration time. Open Life Sciences 12 (1):42–50. doi: https://doi.org/10.1515/biol-2017-0005.
- Bartowsky, E. J. , P. A. Henschke , P. B. Høj , and I. S. Pretorius . 2004. Chasing wine aroma: Does Oenococcus oeni have the potential to release aroma compounds from authentic grape precursors. Australian and New Zealand Wine Industry 19:24–31.
- Battilana, J. , L. Costantini , F. Emanuelli , F. Sevini , C. Segala , S. Moser , R. Velasco , G. Versini , and M. S. Grando . 2009. The 1-deoxy-d-xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine. Theoretical and Applied Genetics 118 (4):653–69. doi: https://doi.org/10.1007/s00122-008-0927-8.
- Battilana, J. , F. Emanuelli , G. Gambino , I. Gribaudo , F. Gasperi , P. K. Boss , and M. S. Grando . 2011. Functional effect of grapevine 1-deoxy-D-xylulose 5-phosphate synthase substitution K284N on Muscat flavour formation. Journal of Experimental Botany 62 (15):5497–508. doi: https://doi.org/10.1093/jxb/err231.
- Baumes, R. , J. Wirth , S. Bureau , Y. Gunata , and A. Razungles . 2002. Biogeneration of C13-norisoprenoid compounds: Experiments supportive for an apo-carotenoid pathway in grapevines. Analytica Chimica Acta 458 (1):3–14. doi: https://doi.org/10.1016/S0003-2670(01)01589-6.
- Belda, I. , J. Ruiz , A. Esteban-Fernández , E. Navascués , D. Marquina , A. Santos , and M. Moreno-Arribas . 2017. Microbial contribution to wine aroma and its intended use for wine quality improvement. Molecules 22 (2):189–29. 20189. doi: https://doi.org/10.3390/molecules220.
- Bennetzen, J. L. , J. Ma , and K. M. Devos . 2005. Mechanisms of recent genome size variation in flowering plants. Annals of Botany 95 (1):127–32. doi: https://doi.org/10.1093/aob/mci008.
- Black, C. A. , M. Parker , T. E. Siebert , D. L. Capone , and I. L. Francis . 2015. Terpenoids and their role in wine flavour: Recent advances. Australian Journal of Grape and Wine Research 21:582–600. doi: https://doi.org/10.1111/ajgw.12186.
- Bönisch, F. , J. Frotscher , S. Stanitzek , E. Rühl , M. Wüst , O. Bitz , and W. Schwab . 2014. A UDP-glucose: Monoterpenol glucosyltransferase adds to the chemical diversity of the grapevine metabolome (Vitis vinifera L). Plant Physiology 165 (2):561–81. doi: https://doi.org/10.1104/pp.113.232470.
- Boutanaev, A. M. , T. Moses , J. Zi , D. R. Nelson , S. T. Mugford , R. J. Peters , and A. Osbourn . 2015. Investigation of terpene diversification across multiple sequenced plant genomes. Proceedings of the National Academy of Sciences of the United States of America 112 (1):E81–E88. doi: https://doi.org/10.1073/pnas.1419547112.
- Budić-Leto, I. , I. Humar , G. Zdunić , J. Hribar , and E. Zlatić . 2016. Volatile compounds in Prošek dessert wines produced from white and red grapes. Czech Journal of Food Sciences 33 (No. 4):354–60. doi: https://doi.org/10.17221/28/2015-CJFS.
- Caputi, L. , S. Carlin , I. Ghiglieno , M. Stefanini , L. Valenti , U. Vrhovsek , and F. Mattivi . 2011. Relationship of changes in rotundone content during grape ripening and winemaking to manipulation of the ‘peppery’ character of wine. Journal of Agricultural and Food Chemistry 59 (10):5565–71. doi: https://doi.org/10.1021/jf200786u.
- Carrau, F. M. , E. Boido , and E. Dellacassa . 2008. Terpenoids in grapes and wines: Origin and micrometabolism during the vinification process. Natural Product Communications 3 (4):1934578X0800300–592. doi: https://doi.org/10.1021/jf991047a.
- Castilla, P. , A. Dávalos , J. L. Teruel , F. Cerrato , M. Fernández-Lucas , J. L. Merino , C. C. SáNchez-Martín , J. Ortuño , and M. A. Lasunción . 2008. Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients. The American Journal of Clinical Nutrition 87 (4):1053–61. 1053. doi: https://doi.org/10.1093/ajcn/87.4.
- Chaïb, J. , L. Torregrosa , D. Mackenzie , P. Corena , A. Bouquet , and M. R. Thomas . 2010. The grape microvine–A model system for rapid forward and reverse genetics of grapevines. The Plant Journal 62 (6):1092. 04219.x. doi: https://doi.org/10.1111/j.1365-313X.2010.
- Chakrabarti, M. , N. A. Zhang , C. Sauvage , S. Muños , J. Blanca , J. Cañizares , M. J. Diez , R. Schneider , M. Mazourek , J. McClead , et al. 2013. A cytochrome P450 regulates a domestication trait in cultivated tomato. Proceedings of the National Academy of Sciences of the United States of America 110 (42):17125–30. 1307313110. doi: https://doi.org/10.1073/pnas.1307313110.
- Chambon, C. , V. Ladeveze , A. Oulmouden , M. Servouse , and F. Karst . 1990. Isolation and properties of yeast mutants affected in farnesyl diphosphate synthetase. Current Genetics 18 (1):41–6. doi: https://doi.org/10.1007/BF00321113.
- Chapman, D. M. , G. Roby , S. E. Ebeler , J.-X. Guinard , and M. A. Matthews . 2005. Sensory attributes of Cabernet Sauvignon wines made from vines with different water status. Australian Journal of Grape and Wine Research 11 (3):339–47. doi: https://doi.org/10.1111/j.1755-0238.2005.tb00033.x.
- Chen, F. , D. Tholl , J. Bohlmann , and E. Pichersky . 2011. The family of terpene synthases in plants: A mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom. The Plant Journal 66 (1):212–29. doi: https://doi.org/10.1111/j.1365-313X.2011.04520.x.
- Cheng, D. W. , H. Lin , Y. Takahachi , A. M. Walker , E. L. Civerolo , and D. C. Stenger . 2010. Transcriptional regulation of the grape cytochrome P450 monooxygenase gene CYP736B expression in response to Xylella fastidiosa infection. BMC Plant Biology 10 (1):135–14. doi: https://doi.org/10.1186/1471-2229-10-135.
- Coelho, E. , M. A. Coimbra , J. M. F. Nogueira , and S. M. Rocha . 2009. Quantification approach for assessment of sparkling wine volatiles from different soils, ripening stages, and varieties by stir bar sorptive extraction with liquid desorption. Analytica Chimica Acta 635 (2):214–21. doi: https://doi.org/10.1016/j.aca.2009.01.013.
- Coelho, E. , S. M. Rocha , I. Delgadillo , and M. A. Coimbra . 2006. Headspace-SPME applied to varietal volatile components evolution during Vitis vinifera L. cv. ‘Baga’ ripening. Analytica Chimica Acta 563 (1–2):204–14. doi: https://doi.org/10.1016/j.aca.2005.11.018.
- Collu, G. , N. Unver , A. M. Peltenburg-Looman , R. van der Heijden , R. Verpoorte , and J. Memelink . 2001. Geraniol 10-hydroxylase1, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis. FEBS Letters 508 (2):215–20. doi: https://doi.org/10.1016/S0014-5793(01)03045-9.
- Dalla Costa, L. , F. Emanuelli , M. Trenti , P. Moreno-Sanz , S. Lorenzi , E. Coller , S. Moser , D. Slaghenaufi , A. Cestaro , R. Larcher , et al. 2018. Induction of terpene biosynthesis in berries of microvine transformed with VvDXS1 alleles. Frontiers in Plant Science 8:2244. doi: https://doi.org/10.3389/fpls.2017.02244.
- Davidovich-Rikanati, R. , Y. Sitrit , Y. Tadmor , Y. Iijima , N. Bilenko , E. Bar , B. Carmona , E. Fallik , N. Dudai , J. E. Simon , et al. 2007. Enrichment of tomato flavor by diversion of the early plastidial terpenoid pathway. Nature Biotechnology 25 (8):899–901. doi: https://doi.org/10.1038/nbt1312.
- Daviet, L. , and M. Schalk . 2010. Biotechnology in plant essential oil production: Progress and perspective in metabolic engineering of the terpene pathway. Flavour and Fragrance Journal 25 (3):123–7. doi: https://doi.org/10.1002/ffj.1981.
- Degenhardt, J. , T. G. Köllner , and J. Gershenzon . 2009. Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants. Phytochemistry 70 (15–16):1621–37. doi: https://doi.org/10.1016/j.phytochem.2009.07.030.
- Diab, A. A. , S. M. Khalil , and R. M. Ismail . 2011. Regeneration and micropropagation of grapevine (Vitis vinifera L.) through shoot tips and axillary buds. International Journal of Advanced Biotechnology and Research 2 (4):484–91.
- Diaz-Chavez, M. L. , J. Moniodis , L. L. Madilao , S. Jancsik , C. I. Keeling , E. L. Barbour , E. L. Ghisalberti , J. A. Plummer , C. G. Jones , and J. Bohlmann . 2013. Biosynthesis of sandalwood oil: Santalum album CYP76F cytochromes P450 produce santalols and bergamotol. PLoS One 8 (9):e75053. doi: https://doi.org/10.1371/journal.pone.0075053.
- D’Incecco, N. , E. Bartowsky , S. Kassara , A. Lante , P. Spettoli , and P. Henschke . 2004. Release of glycosidically bound flavour compounds of Chardonnay by Oenococcus oeni during malolactic fermentation. Food Microbiology 21 (3):257–65. doi: https://doi.org/10.1016/j.fm.2003.09.003.
- Drew, D. P. , T. B. Andersen , C. Sweetman , B. L. Møller , C. Ford , and H. T. Simonsen . 2016. Two key polymorphisms in a newly discovered allele of the Vitis vinifera TPS24 gene are responsible for the production of the rotundone precursor α-guaiene. Journal of Experimental Botany 67 (3):799–808. doi: https://doi.org/10.1093/jxb/erv491.[Mismatch]
- Duchêne, E. , G. Butterlin , P. Claudel , V. Dumas , N. Jaegli , and D. Merdinoglu . 2009. A grapevine (Vitis vinifera L.) deoxy-D-xylulose synthase gene colocates with a major quantitative trait locus for terpenol content. Theoretical and Applied Genetics 118 (3):541–52. doi: https://doi.org/10.1007/s00122-008-0919-8.
- Dueholm, B. , D. P. Drew , C. Sweetman , and H. T. Simonsen . 2019. In planta and in silico characterization of five sesquiterpene synthases from Vitis vinifera (cv. Shiraz) berries. Planta 249 (1):59–70. doi: https://doi.org/10.1007/s00425-018-2986-7.
- Dunlevy, J. D. , C. M. Kalua , R. A. Keyzers , and P. K. Boss . 2009. The production of flavour and aroma compounds in grape berries. In Grapevine molecular physiology and biotechnology , 293–340. 2nd ed. Dordrecht: Springer. doi: https://doi.org/10.1007/978-90-481-2305-6_11.
- Ebeler, S. E. 2001. Analytical chemistry: Unlocking the secrets of wine flavor. Food Reviews International 17 (1):45–64. doi: https://doi.org/10.1081/FRI-100000517.
- Ebeler, S. E. , and J. H. Thorngate . 2009. Wine chemistry and flavor: Looking into the crystal glass. Journal of Agricultural and Food Chemistry 57 (18):8098–108. doi: https://doi.org/10.1021/jf9000555.
- Emanuelli, F. , J. Battilana , L. Costantini , L. L. Cunff , J.-M. Boursiquot , P. This , and M. S. Grando . 2010. A candidate gene association study on Muscat flavor in grapevine (Vitis vinifera L.). BMC Plant Biology 10 (1):2411–7. doi: https://doi.org/10.1186/1471-2229-10-241.
- Falcao, L. D. , G. de Revel , M. C. Perello , L. Riquier , J. P. Rosier , A. A. A. Uberti , and M. T. Bordignon-Luiz . 2008. Volatile profile characterization of young Cabernet-Sauvignon wines from a new grape growing region in Brazil. Oeno One 42 (3):133–45. 3.814. doi: https://doi.org/10.20870/oeno-one.2008.42.
- Fernández-González, M. , R. D. Stefano , and A. Briones . 2003. Hydrolysis and transformation of terpene glycosides from Muscat must by different yeast species. Food Microbiology 20 (1):35–41. doi: https://doi.org/10.1016/S0740-0020(02)00105-3.
- Francis, I. L. , and J. L. Newton . 2005. Determining wine aroma from compositional data. Australian Journal of Grape and Wine Research 11 (2):114–26. doi: https://doi.org/10.1111/j.1755-0238.2005.tb00283.x.
- Fraser, P. D. , E. M. Enfissi , and P. M. Bramley . 2009. Genetic engineering of carotenoid formation in tomato fruit and the potential application of systems and synthetic biology approaches. Archives of Biochemistry and Biophysics 483 (2):196–204. doi: https://doi.org/10.1016/j.abb.2008.10.009.
- Freedman, J. E. , C. Parker , L. Li , J. A. Perlman , B. Frei , V. Ivanov , L. R. Deak , M. D. Iafrati , and J. D. Folts . 2001. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103 (23):2792–8. doi: https://doi.org/10.1161/01.CIR.103.23.2792.
- Fukushima, E. O. , H. Seki , K. Ohyama , E. Ono , N. Umemoto , M. Mizutani , K. Saito , and T. Muranaka . 2011. CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. Plant and Cell Physiology 52 (12):2050–61. doi: https://doi.org/10.1093/pcp/pcr146.
- Geffroy, O. , T. Dufourcq , D. Carcenac , T. Siebert , M. Herderich , and E. Serrano . 2014. Effect of ripeness and viticultural techniques on the rotundone concentration in red wine made from Vitis vinifera L. cv. Duras. Australian Journal of Grape and Wine Research 20 (3):401–8. doi: https://doi.org/10.1111/ajgw.12084.
- Gil-Sánchez, I. , B. B. Suáldea , and M. V. Moreno-Arribas . 2019. In Malolactic fermentation , ed. A. Morata , 85–98. Red Wine Technology, Academic Press. doi: https://doi.org/10.1016/B978-0-12-814399-5.00006-2.
- Ginglinger, J.-F. , B. Boachon , R. Hofer , C. Paetz , T. G. Kollner , L. Miesch , R. Lugan , R. Baltenweck , J. Mutterer , P. Ullmann , et al. 2013. Gene coexpression analysis reveals complex metabolism of the monoterpene alcohol linalool in Arabidopsis flowers. The Plant Cell 25 (11):4640–57. doi: https://doi.org/10.1105/tpc.113.117382.
- Goff, S. A. , D. Ricke , T. H. Lan , G. Presting , R. Wang , M. Dunn , and D. Hadley . 2002. A draft sequence of the rice genome (Oryza sativa L. ssp. japonica). Science 296 (5565):92–100. doi: https://doi.org/10.1126/science.1068275.
- Goff, S. A. , and H. J. Klee . 2006. Plant volatile compounds: Sensory cues for health and nutritional value. Science 311 (5762):815–9. doi: https://doi.org/10.1126/science.1112614.
- González-Barreiro, C. , R. Rial-Otero , B. Cancho-Grande , and J. Simal-Gándara . 2015. Wine aroma compounds in grapes: A critical review. Critical Reviews in Food Science and Nutrition 55 (2):202–18. doi: https://doi.org/10.1080/10408398.2011.650336.
- Gray, D. J. , Z. T. Li , and S. A. Dhekney . 2014. Precision breeding of grapevine (Vitis vinifera L.) for improved traits. Plant Science 228:3–10. 2014.03.023. doi: https://doi.org/10.1016/j.plantsci.
- Grazia, A. , A. Pietrafesa , A. Capece , R. Pietrafesa , G. Siesto , and P. Romano . 2019. Exploitation of technological variability among wild non-Saccharomyces yeasts to select mixed starters for the production of low alcohol wines. BIO Web of Conferences 15:02031. doi: https://doi.org/10.1051/bioconf/20191502031.
- Grimaldi, A. , E. Bartowsky , and V. Jiranek . 2005. A survey of glycosidase activities of commercial wine strains of Oenococcus oeni . International Journal of Food Microbiology 105 (2):233–44. doi: https://doi.org/10.1016/j.ijfoodmicro.2005.04.011.
- Grimplet, J. , J. Van Hemert , P. Carbonell-Bejerano , J. Díaz-Riquelme , J. Dickerson , A. Fennell , M. Pezzotti , and J. M. Martínez-Zapater . 2012. Comparative analysis of grapevine whole-genome gene predictions, functional annotation, categorization and integration of the predicted gene sequences. BMC Research Notes 5 (1):1–10. doi: https://doi.org/10.1186/1756-0500-5-213.
- Gunata, Z. , S. Bitteur , J. M. Brillouet , C. Bayonove , and R. Cordonnier . 1988. Sequential enzymic hydrolysis of potentially aromatic glycosides from grape. Carbohydrate Research 184:139–49. doi: https://doi.org/10.1016/0008-6215(88)80012-0.
- Guth, H. 1997. Identification of character impact odorants of different white wine varieties. Journal of Agricultural and Food Chemistry 45 (8):3022–6. doi: https://doi.org/10.1021/jf9608433.
- Haerizadeh, F. , C. E. Wong , P. L. Bhalla , P. M. Gresshoff , and M. B. Singh . 2009. Genomic expression profiling of mature soybean (Glycine max) pollen. BMC Plant Biology 9 (1):25–12. doi: https://doi.org/10.1186/1471-2229-9-25.
- Hamberger, B. , and S. Bak . 2013. Plant P450s as versatile drivers for evolution of species-specific chemical diversity. Philosophical Transactions of the Royal Society B: Biological Sciences 368 (1612):20120426. doi: https://doi.org/10.1098/rstb.2012.0426.
- Hamberger, B. , T. Ohnishi , B. Hamberger , A. Séguin , and J. Bohlmann . 2011. Evolution of diterpene metabolism: Sitka spruce CYP720B4 catalyses multiple oxidations in resin acid biosynthesis of conifer defense against insects. Plant Physiology 157 (4):1677–95. doi: https://doi.org/10.1104/pp.111.185843.
- Han, J. Y. , H. S. Hwang , S. W. Choi , H. J. Kim , and Y. E. Choi . 2012. Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng . Plant and Cell Physiology 53 (9):1535–45. doi: https://doi.org/10.1093/pcp/pcs106.
- Han, N. , and M. Bakovic . 2015. Biologically active triterpenoids and their cardioprotective and anti-inflammatory effects. Journal of Bioanalysis and Biomedicine 12 (005):1948–55. doi: https://doi.org/10.4172/1948-593X.S12-005.
- Helliwell, C. A. , P. M. Chandler , A. Poole , E. S. Dennis , and W. J. Peacock . 2001. The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway. Proceedings of the National Academy of Sciences of the United States of America 98 (4):2065–70. doi: https://doi.org/10.1073/pnas.98.4.2065.
- Herderich, M. J. , T. E. Siebert , M. Parker , D. L. Capone , D. W. Jeffery , P. Osidacz , and I. L. Francis . 2012. Spice up your life: Analysis of key aroma compounds in shiraz. In Flavor chemistry of wine and other alcoholic beverages , vol. 1 (1104), 3–13. American Chemical Society, Flavor Chemistry of Wine and Other Alcoholic Beverages. doi: https://doi.org/10.1021/bk-2012-1104.ch001.
- Hernández, L. F. , J. C. Espinosa , M. Fernández-González , and A. Briones . 2003. β-Glucosidase activity in a Saccharomyces cerevisiae wine strain. International Journal of Food Microbiology 80 (2):171–6. doi: https://doi.org/10.1016/s0168-1605(02)00149-6.
- Höfer, R. , L. Dong , F. André , J. F. Ginglinger , R. Lugan , C. Gavira , S. Grec , G. Lang , J. Memelink , S. Van der Krol , et al. 2013. Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco) iridoid pathway. Metabolic Engineering 20:221–32. doi: https://doi.org/10.1016/j.ymben.2013.08.001.
- Holt, S. , A. G. Cordente , and C. Curtin . 2012. Saccharomyces cerevisiae STR3 and yeast cystathionine β-lyase enzymes: The potential for engineering increased flavor release. Bioengineered 3 (3):180–2. doi: https://doi.org/10.4161/bbug.19566.
- Huang, M. , C. Abel , R. Sohrabi , J. Petri , I. Haupt , J. Cosimano , J. Gershenzon , and D. Tholl . 2010. Variation of herbivore-induced volatile terpenes among Arabidopsis ecotypes depends on allelic differences and subcellular targeting of two terpene synthases, TPS02 and TPS03. Plant Physiology 153 (3):1293–310. doi: https://doi.org/10.1104/pp.110.154864.
- Hyma, K. E. , P. Barba , M. Wang , J. P. Londo , C. B. Acharya , S. E. Mitchell , Q. Sun , B. Reisch , and L. Cadle-Davidson . 2015. Heterozygous mapping strategy (HetMappS) for high resolution genotyping-by-sequencing markers: A case study in grapevine. PLoS One 10 (8):e0134880. doi: https://doi.org/10.1371/journal.pone.0134880.
- Ikezawa, N. , J. C. Göpfert , D. T. Nguyen , S.-U. Kim , P. E. O'Maille , O. Spring , and D.-K. Ro . 2011. Lettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio-and stereo-selective hydroxylations in sesquiterpene lactone metabolism. Journal of Biological Chemistry 286 (24):21601–11. doi: https://doi.org/10.1074/jbc.M110.216804.
- Ikram, N. K. B. K. , X. Zhan , X. W. Pan , B. C. King , and H. T. Simonsen . 2015. Stable heterologous expression of biologically active terpenoids in green plant cells. Frontiers in Plant Science 6:129. doi: https://doi.org/10.3389/fpls.2015.00129.
- Ilc, T. , D. Halter , L. Miesch , F. Lauvoisard , L. Kriegshauser , A. Ilg , R. Baltenweck , P. Hugueney , D. Werck-Reichhart , E. Duchêne , et al. 2017. A grapevine cytochrome P450 generates the precursor of wine lactone, a key odorant in wine. New Phytologist 213 (1):264–74. doi: https://doi.org/10.1111/nph.14139.
- Ilc, T. , D. Werck-Reichhart , and N. Navrot . 2016. Meta-analysis of the core aroma components of grape and wine aroma. Frontiers in Plant Science 7 (1472):1–15. doi: https://doi.org/10.3389/fpls.2016.01472.
- Ilc, T. , G. Arista , R. Tavares , N. Navrot , E. Duchêne , A. Velt , F. Choulet , E. Paux , M. Fischer , D. R. Nelson , et al. 2018. Annotation, classification, genomic organization and expression of the Vitis vinifera CYPome. PLoS One 13 (6):e0199902. doi: https://doi.org/10.1371/journal.pone.0199902.
- Iorizzo, M. , B. Testa , S. J. Lombardi , A. García-Ruiz , C. Muñoz-González , B. Bartolomé , and M. V. Moreno-Arribas . 2016. Selection and technological potential of Lactobacillus plantarum bacteria suitable for wine malolactic fermentation and grape aroma release. LWT 73:557–66. doi: https://doi.org/10.1016/j.lwt.2016.06.062.
- Jaillon, O. , J. M. Aury , B. Noel , A. Policriti , C. Clepet , A. Casagrande , N. Choisne , S. Aubourg , N. Vitulo , C. Jubin , et al. 2007. The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla. Nature 449 (7161):463–7. doi: https://doi.org/10.1038/nature06148.
- Ji, T. , and I. E. Dami . 2008. Characterization of free flavor compounds in traminette grape and their relationship to vineyard training system and location. Journal of Food Science 73 (4):C262–C267. doi: https://doi.org/10.1111/j.1750-3841.2008.00736.x.
- Jiang, B. , and Z. Zhang . 2010. Volatile compounds of young wines from Cabernet Sauvignon, Cabernet Gernischet and Chardonnay varieties grown in the Loess Plateau Region of China. Molecules 15 (12):9184–96. 29184. doi: https://doi.org/10.3390/molecules151.
- Kalua, C. M. , and P. K. Boss . 2009. Evolution of volatile compounds during the development of Cabernet Sauvignon grapes (Vitis vinifera L.). Journal of Agricultural and Food Chemistry 57 (9):3818–30. doi: https://doi.org/10.1021/jf803471n.
- Kappers, I. F. , A. Aharoni , T. W. Van Herpen , L. L. Luckerhoff , M. Dicke , and H. J. Bouwmeester . 2005. Genetic engineering of terpenoid metabolism attracts bodyguards to Arabidopsis . Science 309 (5743):2070–2. 16232. doi: https://doi.org/10.1126/science.11.
- Keilwagen, J. , H. Lehnert , T. Berner , H. Budahn , T. Nothnagel , D. Ulrich , and F. Dunemann . 2017. The terpene synthase gene family of carrot (Daucus carota L.): Identification of QTLs and candidate genes associated with terpenoid volatile compounds. Frontiers in Plant Science 8 (1930):1–18. doi: https://doi.org/10.3389/fpls.2017.01930.
- King, A. , and J. D. Richard . 2000. Biotransformation of monoterpene alcohols by Saccharomyces cerevisiae, Torulaspora delbrueckii and Kluyveromyces lactis . Yeast 16 (6):499–506. YEA548 > 3.0.CO;2-E. doi: https://doi.org/10.1002/(SICI)1097-0061(200004)16:6 < 499::AID-.
- Kuchen, B. , F. Vazquez , M. V. Mestre , M. E. Toro , and Y. P. Maturano . 2018. Influence of cold maceration time on chromatic and microbiological characteristics of Cabernet Sauvignon wines. South African Journal of Enology and Viticulture 39 (1):89–99. doi: https://doi.org/10.21548/39-1-2460.
- Lewinsohn, E. , F. Schalechet , J. Wilkinson , K. Matsui , Y. Tadmor , K.-H. Nam , O. Amar , E. Lastochkin , O. Larkov , U. Ravid , et al. 2001. Enhanced levels of the aroma and flavor compound S-linalool by metabolic engineering of the terpenoid pathway in tomato fruits. Plant Physiology 127 (3):1256–65. doi: https://doi.org/10.1104/pp.010293.
- Liu, J. , X.-L. Zhu , N. Ullah , and Y.-S. Tao . 2017. Aroma glycosides in grapes and wine. Journal of Food Science 82 (2):248–59. doi: https://doi.org/10.1111/1750-3841.13598.
- Liu, S. Q. 2002. Malolactic fermentation in wine–beyond deacidification. Journal of Applied Microbiology 92 (4):589–601. doi: https://doi.org/10.1046/j.1365-2672.2002.01589.x.
- Luan, F. , A. Mosandl , A. Munch , and M. Wust . 2005. Metabolism of geraniol in grape berry mesocarp of Vitis vinifera L. cv. Scheurebe: Demonstration of stereoselective reduction, E/Z-isomerization, oxidation and glycosylation. Phytochemistry 66 (3):295–303. doi: https://doi.org/10.1016/j.phytochem.2004.12.017.
- Luan, F. , and M. Wüst . 2002. Differential incorporation of 1-deoxy-D-xylulose into (3S)-linalool and geraniol in grape berry exocarp and mesocarp. Phytochemistry 60 (5):451–9. doi: https://doi.org/10.1016/S0031-9422(02)00147-4.
- Lücker, J. , W. Schwab , B. van Hautum , J. Blaas , L. H. van der Plas , H. J. Bouwmeester , and H. A. Verhoeven . 2004. Increased and altered fragrance of tobacco plants after metabolic engineering using three monoterpene synthases from lemon. Plant Physiology 134 (1):510–9. doi: https://doi.org/10.1104/pp.103.030189.
- Luo, P. , Y. H. Wang , G. D. Wang , M. Essenberg , and X. Y. Chen . 2001. Molecular cloning and functional identification of (+) δ-cadinene-8-hydroxylase, a cytochrome P450mono-oxygenase (CYP706B1) of cotton sesquiterpene biosynthesis. The Plant Journal 28 (1):95–104. doi: https://doi.org/10.1046/j.1365-313X.2001.01133.x.
- Lupien, S. , F. Karp , M. Wildung , and R. Croteau . 1999. Regiospecific cytochrome P450 limonene hydroxylases from mint (Mentha) species: CDNA isolation, characterization, and functional expression of (−)-4S-limonene-3-hydroxylase and (−)-4S-limonene-6-hydroxylase. Archives of Biochemistry and Biophysics 368 (1):181–92. doi: https://doi.org/10.1006/abbi.1999.1298.
- Maicas, S. , and J. J. Mateo . 2005. Hydrolysis of terpenyl glycosides in grape juice and other fruit juices: A review. Applied Microbiology and Biotechnology 67 (3):322–35. doi: https://doi.org/10.1007/s00253-004-1806-0.
- Marais, J. 1983. Terpenes in the aroma of grapes and wines: A review. South African Journal of Enology and Viticulture 4 (2):49–58.
- Marais, J. , C. J. van Wyk , and A. Rapp . 1992. Effect of sunlight and shade on norisoprenoid levels in maturing Weisser Riesling and Chenin Blanc grapes and Weisser Riesling wines. South African Journal of Enology and Viticulture 13 (1):23–32. doi: https://doi.org/10.21548/13-1-2191.
- Martin, D. M. , A. Chiang , S. T. Lund , and J. Bohlmann . 2012. Biosynthesis of wine aroma: Transcript profiles of hydroxymethylbutenyl diphosphate reductase, geranyl diphosphate synthase, and linalool/nerolidol synthase parallel monoterpenol glycoside accumulation in Gewürztraminer grapes. Planta 236 (3):919–29. doi: https://doi.org/10.1007/s00425-012-1704-0.
- Martin, D. M. , S. Aubourg , M. B. Schouwey , L. Daviet , M. Schalk , O. Toub , S. T. Lund , and J. Bohlmann . 2010. Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. BMC Plant Biology 10 (1):226. doi: https://doi.org/10.1186/1471-2229-10-226.
- Martínez-Zapater, J. M. , M. J. Carmona , J. Dãaz-Riquelme , L. Fernãndez , and D. Lijavetzky . 2010. Grapevine genetics after the genome sequence: Challenges and limitations. Australian Journal of Grape and Wine Research 16:33–46. doi: https://doi.org/10.1111/j.1755-0238.2009.00073.x.
- Matarese, F. , A. Cuzzola , G. Scalabrelli , and C. D’Onofrio . 2014. Expression of terpene synthase genes associated with the formation of volatiles in different organs of Vitis vinifera . Phytochemistry 105:12–24. doi: https://doi.org/10.1016/j.phytochem.2014.06.007.
- Matarese, F. , G. Scalabrelli , and C. D'Onofrio . 2013. Analysis of the expression of terpene synthase genes in relation to aroma content in two aromatic Vitis vinifera varieties. Functional Plant Biology 40 (6):552–65. doi: https://doi.org/10.1071/FP12326.
- Mathieu, S. , N. Terrier , J. Procureur , F. Bigey , and Z. Günata . 2005. A carotenoid cleavage dioxygenase from Vitis vinifera L.: Functional characterization and expression during grape berry development in relation to C13-norisoprenoid accumulation. Journal of Experimental Botany 56 (420):2721–31. doi: https://doi.org/10.1093/jxb/eri265.
- Mau, C. J. , F. Karp , M. Ito , G. Honda , and R. B. Croteau . 2010. A candidate cDNA clone for (−) - limonene - 7 - hydroxylase from Perilla frutescens . Phytochemistry 71 (4):373–9. doi: https://doi.org/10.1016/j.phytochem.2009.12.002.
- May, B. , B. M. Lange , and M. Wüst . 2013. Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: Evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. Phytochemistry 95:135–44. doi: https://doi.org/https://doi.org/10.1016/j.phytochem.2013.07.021.
- Mayr, C. M. , M. Parker , G. A. Baldock , C. A. Black , K. H. Pardon , P. O. Williamson , M. J. Herderich , and I. L. Francis . 2014. Determination of the importance of in-mouth release of volatile phenol glycoconjugates to the flavor of smoke-tainted wines. Journal of Agricultural and Food Chemistry 62 (11):2327–36. doi: https://doi.org/10.1021/jf405327s.
- McKay, M. , F. F. Bauer , V. Panzeri , and A. Buica . 2020. Investigation of olfactory interactions of low levels of five off-flavour causing compounds in a red wine matrix. Food Research International 128:108878. doi: https://doi.org/10.1016/j.foodres.2019.108878.
- Meinke, D. W. , J. M. Cherry , C. Dean , S. D. Rounsley , and M. Koornneef . 1998. Arabidopsis thaliana: A model plant for genome analysis. Science 282 (5389):662–82. doi: https://doi.org/10.1126/science.282.5389.662.
- Mele, M. A. , M. Z. Islam , J. P. Baek , and H. M. Kang . 2017. Quality, storability, and essential oil content of Ligularia fischeri during modified atmosphere packaging storage. Journal of Food Science and Technology 54 (3):743–50. doi: https://doi.org/10.1007/s13197-017-2514-y.
- Meredith, C. P. 2001. Grapevine genetics: Probing the past and facing the future. Agriculturae Conspectus Scientificus 66 (1):21–5.
- Miettinen, K. , L. Dong , N. Navrot , T. Schneider , V. Burlat , J. Pollier , L. Woittiez , S. van der Krol , R. Lugan , T. Ilc , et al. 2014. The seco-iridoid pathway from Catharanthus roseus . Nature Communications 5 (1):3606. doi: https://doi.org/10.1038/ncomms4606.
- Minnaar, P. P. , H. W. Du Plessis , N. P. Jolly , M. van der Rijst , and M. Du Toit . 2019. Non-Saccharomyces yeast and lactic acid bacteria in Co-inoculated fermentations with two Saccharomyces cerevisiae yeast strains: A strategy to improve the phenolic content of Syrah wine. Food Chemistry: X 4:100070. doi: https://doi.org/10.1016/j.fochx.2019.100070.
- Mizutani, M. 2012. Impacts of diversification of cytochrome P450 on plant metabolism. Biological and Pharmaceutical Bulletin 35 (6):824–32. doi: https://doi.org/10.1248/bpb.35.824.
- Mysore, K. S. , R. P. Tuori , and G. B. Martin . 2001. Arabidopsis genome sequence as a tool for functional genomics in tomato. Genome Biology 2 (1):reviews1003.1–4. doi: https://doi.org/10.1186/gb-2001-2-1-reviews1003.
- Nafisi, M. , S. Goregaoker , C. J. Botanga , E. Glawischnig , C. E. Olsen , B. A. Halkier , and J. Glazebrook . 2007. Arabidopsis cytochrome P450 monooxygenase 71A13 catalyzes the conversion of indole-3-acetaldoxime in camalexin synthesis. The Plant Cell 19 (6):2039–52. doi: https://doi.org/10.1105/tpc.107.051383.
- Nelson, D. , and D. Werck-Reichhart . 2011. A P450-centric view of plant evolution. The Plant Journal 66 (1):194–211. doi: https://doi.org/10.1111/j.1365-313X.2011.04529.x.
- Nelson, D. R. , R. Ming , M. Alam , and M. A. Schuler . 2008. Comparison of cytochrome P450 genes from six plant genomes. Tropical Plant Biology 1 (3–4):216–35. doi: https://doi.org/10.1007/s12042-008-9022-1.
- Ong, P. K. , and T. E. Acree . 1999. Similarities in the aroma chemistry of Gewürztraminer variety wines and lychee (Litchi chinesis Sonn.) fruit. Journal of Agricultural and Food Chemistry 47 (2):665–70. doi: https://doi.org/10.1021/jf980452j.
- Paddon, C. J. , P. J. Westfall , D. J. Pitera , K. Benjamin , K. Fisher , D. McPhee , M. D. Leavell , A. Tai , A. Main , D. Eng , et al. 2013. High-level semi-synthetic production of the potent antimalarial artemisinin. Nature 496 (7446):528–32. 12051. doi: https://doi.org/10.1038/nature.
- Paine, J. A. , C. A. Shipton , S. Chaggar , R. M. Howells , M. J. Kennedy , G. Vernon , S. Y. Wright , E. Hinchliffe , J. L. Adams , A. L. Silverstone , et al. 2005. Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nature Biotechnology 23 (4):482–7. doi: https://doi.org/10.1038/nbt1082.
- Park, S. K. , J. C. Morrison , D. O. Adams , and A. C. Noble . 1991. Distribution of free and glycosidically bound monoterpenes in the skin and mesocarp of Muscat of Alexandria grapes during development. Journal of Agricultural and Food Chemistry 39 (3):514–8. doi: https://doi.org/10.1021/jf00003a017.
- Parker, M. , A. P. Pollnitz , D. Cozzolino , I. L. Francis , and M. J. Herderich . 2007. Identification and quantification of a marker compound for ‘Pepper’ aroma and flavor in shiraz grape berries by combination of chemometrics and gas chromatography-mass spectrometry. Journal of Agricultural and Food Chemistry 55 (15):5948–55. doi: https://doi.org/10.1021/jf0705320.
- Pateraki, I. , A. M. Heskes , and B. Hamberger . 2015. Cytochromes P450 for terpene functionalisation and metabolic engineering. Biotechnology of Isoprenoids . In Advances in Biochemical Engineering/Biotechnology , 107–39. Cham: Springer. doi: https://doi.org/10.1007/10_2014_301.
- Pensec, F. , C. Pączkowski , M. Grabarczyk , A. Woźniak , M. Bénard-Gellon , C. Bertsch , J. Chong , and A. Szakiel . 2014. Changes in the triterpenoid content of cuticular waxes during fruit ripening of eight grape (Vitis vinifera) cultivars grown in the Upper Rhine Valley. Journal of Agricultural and Food Chemistry 62 (32):7998–8007. doi: https://doi.org/10.1021/jf502033s.
- Pinot, F. , and F. Beisson . 2011. Cytochrome P450 metabolizing fatty acids in plants: Characterization and physiological roles. FEBS Journal 278 (2):195–205. doi: https://doi.org/10.1111/j.1742-4658.2010.07948.x.
- Qian, M. C. , Y. Fang , and K. Shellie . 2009. Volatile composition of Merlot wine from different vine water status. Journal of Agricultural and Food Chemistry 57 (16):7459–63. doi: https://doi.org/10.1021/jf9009558.
- Ralston, L. , S. T. Kwon , M. Schoenbeck , J. Ralston , D. J. Schenk , R. M. Coates , and J. Chappell . 2001. Cloning, heterologous expression, and functional characterization of 5-epi-aristolochene-1, 3-dihydroxylase from tobacco (Nicotiana tabacum). Archives of Biochemistry and Biophysics 393 (2):222–35. doi: https://doi.org/10.1006/abbi.2001.2483.
- Rapp, A. , and H. Mandery . 1986. Wine aroma. Experientia 42 (8):873–84. doi: https://doi.org/10.1007/BF01941764.
- Reynolds, A. G. , and D. A. Wardle . 1989. Influence of fruit microclimate on monoterpene levels of Gewürztraminer. American Journal of Enology and Viticulture 40:149–54.
- Reynolds, A. G. , D. A. Wardle , and A. P. Naylor. 1996 . Impact of training system, vine spacing, and basal leaf removal on Riesling. Vine performance, berry composition, canopy microclimate, and vineyard labor requirements. American Journal of Enology and Viticulture 47:63–76.
- Reynolds, A. G. , D. A. Wardle , and M. Dever . 1996a. Vine performance, fruit composition, and wine sensory attributes of Ge¨urztraminer in response to vineyard location and canopy manipulation. American Journal of Enology and Viticulture 47:77–92.
- Reynolds, A. G. , D. A. Wardle , and M. Dever . 1996b. Vine performance, fruit composition, and wine sensory attributes of Gewürztraminer in response to vineyard location and canopy manipulation. American Journal of Enology and Viticulture 47 (1):77–92.
- Ribéreau-Gayon, P. , J. N. Boidron , and A. Terrier . 1975. Aroma of Muscat grape varieties. Journal of Agricultural and Food Chemistry 23 (6):1042–7. doi: https://doi.org/10.1021/jf60202a050.
- Río Segade, S. , M. Vilanova , S. Giacosa , I. Perrone , W. Chitarra , M. Pollon , F. Torchio , P. Boccacci , G. Gambino , V. Gerbi , et al. 2017. Ozone improves the aromatic fingerprint of white grapes. Scientific Reports 7 (1):1–16. doi: https://doi.org/10.1038/s41598-017-16529-5.
- Ro, D. K. , G. I. Arimura , S. Y. Lau , E. Piers , and J. Bohlmann . 2005. Loblolly pine abietadienol/abietadienal oxidase PtAO (CYP720B1) is a multifunctional, multisubstrate cytochrome P450 monooxygenase. Proceedings of the National Academy of Sciences of the United States of America 102 (22):8060–5. doi: https://doi.org/10.1073/pnas.0500825102.
- Robinson, A. L. , P. K. Boss , P. S. Solomon , R. D. Trengove , H. Heymann , and S. E. Ebeler . 2014. Origins of grape and wine aroma. Part 1. Chemical components and viticultural impacts. American Journal of Enology and Viticulture 65 (1):1–24. doi: https://doi.org/10.5344/ajev.2013.12070.
- Romano, P. , C. Fiore , M. Paraggio , M. Caruso , and A. Capece . 2003. Function of yeast species and strains in wine flavour. International Journal of Food Microbiology 86 (1–2):169–80. doi: https://doi.org/10.1016/S0168-1605(03)00290-3.
- Rosi, I. , M. Vinella , and P. Domizio . 1994. Characterization of β-glucosidase activity in yeasts of oenological origin. Journal of Applied Bacteriology 77 (5):519–27. doi: https://doi.org/10.1111/j.1365-2672.1994.tb04396.x.
- Sabon, I. , G. De Revel , Y. Kotseridis , and A. Bertrand . 2002. Determination of volatile compounds in Grenache wines in relation with different terroirs in the Rhone Valley. Journal of Agricultural and Food Chemistry 50 (22):6341–5. doi: https://doi.org/10.1021/jf025611k.
- Salim, V. , B. Wiens , S. Masada-Atsumi , F. Yu , and V. De Luca . 2014. 7-deoxyloganetic acid synthase catalyzes a key 3 step oxidation to form 7-deoxyloganetic acid in Catharanthus roseus iridoid biosynthesis. Phytochemistry 101:23–31. doi: https://doi.org/10.1016/j.phytochem.2014.02.009.
- Sánchez-Mora, F. D. , L. Saifert , J. Zanghelini , W. T. Assumpção , C. A. Guginski-Piva , R. Giacometti , E. I. Novak , G. H. Klabunde , R. Eibach , L. Dal Vesco , et al. 2017. Behavior of grape breeding lines with distinct resistance alleles to downy mildew (Plasmopara viticola). Crop Breeding and Applied Biotechnology 17 (2):141–9. doi: https://doi.org/10.1590/1984-70332017v17n2a21.
- Scarlett, N. J. , R. G. V. Bramley , and T. E. Siebert . 2014. Within-vineyard variation in the ‘pepper’ compound rotundone is spatially structured and related to variation in the land underlying the vineyard. Australian Journal of Grape and Wine Research 20 (2):214–22. doi: https://doi.org/10.1111/ajgw.12075.
- Schalk, M. , and R. Croteau . 2000. A single amino acid substitution (F363I) converts the regiochemistry of the spearmint (−)-limonene hydroxylase from a C6-to a C3-hydroxylase. Proceedings of the National Academy of Sciences of the United States of America 97 (22):11948–53. doi: https://doi.org/10.1073/pnas.97.22.11948.
- Schwab, W. , T. C. Fischer , A. Giri , and M. Wüst . 2015. Potential applications of glucosyltransferases in terpene glucoside production: Impacts on the use of aroma and fragrance. Applied Microbiology and Biotechnology 99 (1):165–74. doi: https://doi.org/10.1007/s00253-014-6229-y.
- Seki, H. , K. Ohyama , S. Sawai , M. Mizutani , T. Ohnishi , H. Sudo , T. Akashi , T. Aoki , K. Saito , and T. Muranaka . 2008. Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin. Proceedings of the National Academy of Sciences of the United States of America 105 (37):14204–9. doi: https://doi.org/10.1073/pnas.0803876105.
- Seki, H. , S. Sawai , K. Ohyama , M. Mizutani , T. Ohnishi , H. Sudo , E. O. Fukushima , T. Akashi , T. Aoki , K. Saito , et al. 2011. Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. The Plant Cell 23 (11):4112–23. doi: https://doi.org/10.1105/tpc.110.082685.
- Shibuya, M. , M. Hoshino , Y. Katsube , H. Hayashi , T. Kushiro , and Y. Ebizuka . 2006. Identification of beta-amyrin and sophoradiol 24-hydroxylase by expressed sequence tag mining and functional expression assay. FEBS Journal 273 (5):948–59. doi: https://doi.org/10.1111/j.1742-4658.2006.05120.x.
- Siebert, T. E. , C. Wood , G. M. Elsey , and A. P. Pollnitz . 2008. Determination of rotundone, the pepper aroma impact compound, in grapes and wine. Journal of Agricultural and Food Chemistry 56 (10):3745–8. doi: https://doi.org/10.1007/s13205-014-0220-2.
- Singh, B. , and R. A. Sharma . 2015. Plant terpenes: Defense responses, phylogenetic analysis, regulation and clinical applications. 3 Biotech 5 (2):129–51. doi: https://doi.org/10.1007/s13205-014-0220-2.
- Slaghenaufi, D. , and M. Ugliano . 2018. Norisoprenoids, sesquiterpenes and terpenoids content of valpolicella wines during aging: Investigating aroma potential in relationship to evolution of tobacco and balsamic aroma in aged wine. Frontiers in Chemistry 6 (6):1–13. doi: https://doi.org/10.3389/fchem.2018.00066.
- Slegers, A. , P. Angers , É. Ouellet , T. Truchon , and K. Pedneault . 2015. Volatile compounds from grape skin, juice and wine from five interspecific hybrid grape cultivars grown in Québec (Canada) for wine production. Molecules 20 (6):10980–1016. doi: https://doi.org/10.3390/molecules200610980.
- Smith, S. , I. C. Codrington , M. Robertson , and R. Smart . 1988. Viticultural and oenological implications of leaf removal for New Zealand vineyards. In Proceedings of the 2nd International Symposium for Cool Climate Viticulture and Oenology , ed. R. E. Smart , 127–33. Auckland, New Zealand: New Zealand Society of Viticulture and Oenology.
- Steel, C. C. , and M. Keller . 2000. Influence of UV-B irradiation on the carotenoid content of Vitis vinifera tissues. Biochemical Society Transactions 28 (6):883–5. doi: https://doi.org/10.1042/bst0280883.
- Strauss, C. R. , B. Wilson , P. R. Gooley , and P. J. Williams . 1986. Role of monoterpenes in grape and wine flavor. ACS Symposium Series 317:222–42. doi: https://doi.org/10.1021/bk-1986-0317.ch018.
- Strauss, M. L. A. , N. P. Jolly , M. G. Lambrechts , and P. Van Rensburg . 2001. Screening for the production of extracellular hydrolytic enzymes by non-Saccharomyces wine yeasts. Journal of Applied Microbiology 91 (1):182–90. doi: https://doi.org/10.1046/j.1365-2672.2001.01379.x.
- Styger, G. , B. Prior , and F. F. Bauer . 2011. Wine flavour and aroma. Journal of Industrial Microbiology & Biotechnology 38 (9):1145–59. doi: https://doi.org/10.1007/s10295-011-1018-4.
- Taiz, L. , and E. Zeiger . 1991. Plant physiology. 3rd ed. United States of America and Canada (both): The Benjamin Publishing Company, Inc.
- Takahashi, S. , Y. Yeo , B. T. Greenhagen , T. McMullin , L. Song , J. Maurina-Brunker , R. Rosson , J. P. Noel , and J. Chappell . 2007. Metabolic engineering of sesquiterpene metabolism in yeast. Biotechnology and Bioengineering 97 (1):170–81. doi: https://doi.org/10.1002/bit.21216.
- Takase, H. , K. Sasaki , H. Shinmori , A. Shinohara , C. Mochizuki , H. Kobayashi , G. Ikoma , H. Saito , H. Matsuo , S. Suzuki , et al. 2016. Cytochrome P450 CYP71BE5 in grapevine (Vitis vinifera) catalyzes the formation of the spicy aroma compound (−)-rotundone. Journal of Experimental Botany 67 (3):787–98. doi: https://doi.org/10.1093/jxb/erv496.
- Tatman, D. , and H. Mo . 2002. Volatile isoprenoid constituents of fruits, vegetables and herbs cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia cells. Cancer Letters 175 (2):129–39. 00723-6. doi: https://doi.org/10.1016/s0304-3835(01).
- Tholl, D. 2006. Terpene synthases and the regulation, diversity and biological roles of terpene metabolism. Current Opinion in Plant Biology 9 (3):297–304. doi: https://doi.org/10.1016/j.pbi.2006.03.014.
- Töpfer, R. , L. Hausmann , M. Harst , E. Maul , E. Zyprian , and R. Eibach . 2011. New horizons for grapevine breeding. In Fruit, Vegetable and Cereal Science and Biotechnology 5 (1):79–100.
- Ugliano, M. , E. J. Bartowsky , J. McCarthy , L. Moio , and P. A. Henschke . 2006. Hydrolysis and transformation of grape glycosidically bound volatile compounds during fermentation with three Saccharomyces yeast strains. Journal of Agricultural and Food Chemistry 54 (17):6322–31. doi: https://doi.org/10.1021/jf0607718.
- Vaccaro, M. , N. Malafronte , M. Alfieri , N. D. Tommasi , and A. Leone . 2014. Enhanced biosynthesis of bioactive abietane diterpenes by overexpressing AtDXS or AtDXR genes in Salvia sclarea hairy roots. Plant Cell, Tissue and Organ Culture (PCTOC) 119 (1):65–77. doi: https://doi.org/10.1007/s11240-014-0514-4.
- Vilanova, M. , and J. M. Oliveira . 2012. Application of gas chromatography on the evaluation of grape and wine aroma in Atlantic viticulture (NW Iberian Peninsula). In Gas chromatography in plant science, wine technology, toxicology and some specific applications ,ed. B. Salih and Ö. Çelikbıçak , 109–46. Croatia: In Tech. ISBN: 978-953-51-0127-7.
- Vilanova, M. , M. Fandiño , S. Frutos-Puerto , and J. J. Cancela . 2019. Assessment fertigation effects on chemical composition of Vitis vinifera L. cv. Food Chemistry 278:636–43. doi: https://doi.org/10.1016/j.foodchem.2018.11.105.
- Vilanova, M. , Z. Genisheva , L. Bescansa , A. Masa , and J. M. Oliveira . 2012. Changes in free and bound fractions of aroma compounds of four Vitis vinifera cultivars at the last ripening stages. Phytochemistry 74:196–205. doi: https://doi.org/10.1016/j.phytochem.2011.10.004.
- Wang, H. , D. A. Nagegowda , R. Rawat , P. Bouvier‐Navé , D. Guo , T. J. Bach , and M. L. Chye . 2012. Overexpression of Brassica juncea wild-type and mutant HMG-CoA synthase 1 in Arabidopsis up-regulates genes in sterol biosynthesis and enhances sterol production and stress tolerance. Plant Biotechnology Journal 10 (1):31–42. doi: https://doi.org/10.1111/j.1467-7652.2011.00631.x.
- Wedler, H. , R. Pemberton , and D. Tantillo . 2015. Carbocations and the complex flavor and bouquet of wine: Mechanistic aspects of terpene biosynthesis in wine grapes. Molecules 20 (6):10781–92. doi: https://doi.org/10.3390/molecules200610781.
- Williams, P. J. , C. R. Strauss , B. Wilson , and R. A. Massy-Westropp . 1982. Studies on the hydrolysis of Vitis vinifera monoterpene precursor compounds and model monoterpene β; -d-glucosidesrationalizing the monoterpene composition of grapes. Journal of Agricultural and Food Chemistry 30 (6):1219–23. doi: https://doi.org/10.1021/jf00114a054.
- Williams, P. J. , C. R. Straws , B. Wilson , C. R. Strauss , and B. Wilson . 1980. Hydroxylated linalool derivatives as precursors of volatile monoterpenes of Muscat Grapes. Journal of Agricultural and Food Chemistry 28 (4):766–71. doi: https://doi.org/10.1021/jf60230a037.
- Winterhalter, P. , and P. Schreier . 1994. C13-Norisoprenoid glycosides in plant tissues: An overview on their occurrence, composition and role as flavour precursors. Flavour and Fragrance Journal 9 (6):281–7. 602. doi: https://doi.org/10.1002/ffj.2730090.
- Wood, C. , T. E. Siebert , M. Parker , D. L. Capone , G. M. Elsey , A. P. Pollnitz , M. Eggers , M. Meier , T. Vossing , S. Widder , et al. 2008. From wine to pepper: Rotundone an obscure sesquiterpene is a potent spicy aroma compound. Journal of Agricultural and Food Chemistry 56 (10):3738–44. doi: https://doi.org/10.1021/jf800183k.
- Wu, Y. , Q. Wang , M. L. Hillwig , and R. J. Peters . 2013. Picking sides: Distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis. Biochemical Journal 454 (2):209–16. doi: https://doi.org/10.1042/BJ20130574.
- Wu, Y. , S. Duan , L. Zhao , Z. Gao , M. Luo , S. Song , W. Xu , C. Zhang , C. Ma , and S. Wang . 2016. Aroma characterization based on aromatic series analysis in table grapes. Scientific Reports 6 (1):31116. doi: https://doi.org/10.1038/srep31116.
- Yuan, F. , and M. C. Qian . 2016. Development of C13-norisoprenoids, carotenoids and other volatile compounds in Vitis vinifera L. Cv. Pinot noir grapes. Food Chemistry 192:633–41. doi: https://doi.org/10.1016/j.foodchem.2015.07.050.
- Zern, T. L. , and M. L. Fernandez . 2005. Cardioprotective effects of dietary polyphenols. The Journal of Nutrition 135 (10):2291–4. 2291. doi: https://doi.org/10.1093/jn/135.10.
- Zhang, P. , S. Barlow , M. Krstic , M. Herderich , S. Fuentes , and K. Howell . 2015. Within-vineyard, within-vine, and within-bunch variability of the rotundone concentration in berries of Vitis vinifera L. cv. Shiraz. Journal of Agricultural and Food Chemistry 63 (17):4276–83. doi: https://doi.org/10.1021/acs.jafc.5b00590.
- Zhang, P. , S. Fuentes , T. Siebert , M. Krstic , M. Herderich , E. W. R. Barlow , and K. Howell . 2016. Terpene evolution during the development of Vitis vinifera L. cv. Shiraz grapes. Food Chemistry 204:463–74. doi: https://doi.org/10.1016/j.foodchem.2016.02.125.
- Zhang, P. , S. Fuentes , Y. Wang , R. Deng , M. Krstic , M. Herderich , E. W. R. Barlow , and K. Howell . 2016. Distribution of rotundone and possible translocation of related compounds amongst grapevine tissues in Vitis vinifera L. cv. Shiraz. Frontiers in Plant Science 7 (7):1–12. doi: https://doi.org/10.3389/fpls.2016.00859.
- Zhang, Y. , J. Nielsen , and Z. Liu . 2017. Engineering yeast metabolism for production of terpenoids for use as perfume ingredients, pharmaceuticals and biofuels. Federation of European Microbiological Society Yeast Research 17 (8):1–11. doi: https://doi.org/10.1093/femsyr/fox080.
- Zi, J. , and R. J. Peters . 2013. Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae. Organic & Biomolecular Chemistry 11 (44):7650–2. doi: https://doi.org/10.1039/c3ob41885e.
- Zietsman, A. J. , D. de Klerk , and P. van Rensburg . 2011. Coexpression of α-l-arabinofuranosidase and β-glucosidase in Saccharomyces cerevisiae . Federation of FEMS Yeast Research 11 (1):88–103. doi: https://doi.org/10.1111/j.1567-1364.2010.00694.x.
- Zoecklein, B. , K. C. Fugelsang , K. C. Gump , and F. S. Nury . 1999. Wine analysis and production . New York: Springer.
- Zoecklein, B. W. , T. K. Wolf , L. P´Elanne , M. K. Miller , and S. S. Birkenmaier . 2008. Effect of vertical shoot-positioned, Smart-Dyson, and Geneva double-curtain training systems on viognier grape and wine composition. American Journal of Enology and Viticulture 59 (1):11–21.