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Polyphenols and obesity prevention: critical insights on molecular regulation, bioavailability and dose in preclinical and clinical settings

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References

  • Agostini, M., E. Schoenmakers, C. Mitchell, I. Szatmari, D. Savage, A. Smith, O. Rajanayagam, R. Semple, J. Luan, L. Bath, et al. 2006. Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance. Cell Metabolism 4 (4):303–11. doi: 10.1016/j.cmet.2006.09.003.
  • Aguirre, L., A. Fernandez-Quintela, N. Arias, and M. P. Portillo. 2014. Resveratrol: Anti-obesity mechanisms of action. Molecules (Basel, Switzerland) 19 (11):18632–55. doi: 10.3390/molecules191118632.
  • Ahn, J., H. Lee, S. Kim, and T. Ha. 2010. Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/beta-catenin signaling. American Journal of Physiology. Cell Physiology 298 (6):C1510–6. doi: 10.1152/ajpcell.00369.2009.
  • Alberdi, G., V. M. Rodriguez, J. Miranda, M. T. Macarulla, N. Arias, C. Andres-Lacueva, and M. P. Portillo. 2011. Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutrition & Metabolism 8 (1):29doi: 10.1186/1743-7075-8-29.
  • Andrade, J. M., A. C. Frade, J. B. Guimaraes, K. M. Freitas, M. T. Lopes, A. L. Guimaraes, A. M. de Paula, C. C. Coimbra, and S. H. Santos. 2014. Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet. European Journal of Nutrition 53 (7):1503–10. doi: 10.1007/s00394-014-0655-6.
  • Andrade, J. M. O., A. S. Barcala-Jorge, G. C. Batista-Jorge, A. F. Paraíso, K. M. d Freitas, D. d F. Lelis, A. L. S. Guimarães, A. M. B. de Paula, and S. H. S. Santos. 2019. Effect of resveratrol on expression of genes involved thermogenesis in mice and humans. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 112:108634doi: 10.1016/j.biopha.2019.108634.
  • Anhe, F. F., T. V. Varin, M. L. Barz, Y. Desjardins, E. Levy, D. Roy, and A. Marette. 2015. Gut microbiota dysbiosis in obesity-linked metabolic diseases and prebiotic potential of polyphenol-rich extracts. Current Obesity Reports 4 (4):389–400. doi: 10.1007/s13679-015-0172-9.
  • Aragonès, G., F. Danesi, D. Del Rio, and P. Mena. 2017. The importance of studying cell metabolism when testing the bioactivity of phenolic compounds. Trends in Food Science & Technology the Technology 69:230–42. doi: 10.1016/j.tifs.2017.02.001.
  • Barathikannan, K., R. Chelliah, M. Rubab, E. B. Daliri, F. Elahi, D. H. Kim, P. Agastian, S. Y. Oh, and D. H. Oh. 2019. Gut microbiome modulation based on probiotic application for anti-obesity: A review on efficacy and validation. Microorganisms Gut Microorganisms 7 (10):456. doi: 10.3390/microorganisms7100456.
  • Barbera, M. J., A. Schluter, N. Pedraza, R. Iglesias, F. Villarroya, and M. Giralt. 2001. Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. The Journal of Biological Chemistry 276 (2):1486–93. doi: 10.1074/jbc.M006246200.
  • Barrera-Reyes, P. K., N. Hernandez-Ramirez, J. Cortes, L. Poquet, K. Redeuil, C. Rangel-Escareno, M. Kussmann, I. Silva-Zolezzi, and M. E. Tejero. 2019. Gene expression changes by high-polyphenols cocoa powder intake: A randomized crossover clinical study. European Journal of Nutrition 58 (5):1887–98. doi: 10.1007/s00394-018-1736-8.
  • Baur, J. A., and D. A. Sinclair. 2006. Therapeutic potential of resveratrol: The in vivo evidence. Nature Reviews. Drug Discovery 5 (6):493–506. doi: 10.1038/nrd2060.
  • Baur, J. A., D. Chen, E. N. Chini, K. Chua, H. Y. Cohen, R. de Cabo, C. Deng, S. Dimmeler, D. Gius, L. P. Guarente, et al. 2010. Dietary restriction: Standing up for sirtuins. Science (New York, N.Y.) 329 (5995):1012–3. author reply 1013-4. doi: 10.1126/science.329.5995.1012.
  • Bleich, S. N., J. Jones-Smith, J. A. Wolfson, X. Zhu, and M. Story. 2015. The complex relationship between diet and health. Health Affairs (Project Hope) 34 (11):1813–20. doi: 10.1377/hlthaff.2015.0606.
  • Bo, S., M. Fadda, D. Fedele, M. Pellegrini, E. Ghigo, and N. Pellegrini. 2020. A Critical Review on the Role of Food and Nutrition in the Energy Balance. Nutrients 12 (4):1161. doi: 10.3390/nu12041161.
  • Bost, F., M. Aouadi, L. Caron, and B. Binetruy. 2005. The role of MAPKs in adipocyte differentiation and obesity. Biochimie87 (1):51–6. doi: 10.1016/j.biochi.2004.10.018.
  • Bracale, R., M. L. Petroni, S. Davinelli, U. Bracale, G. Scapagnini, M. O. Carruba, and E. Nisoli. 2014. Muscle uncoupling protein 3 expression is unchanged by chronic ephedrine/caffeine treatment: Results of a double blind, randomised clinical trial in morbidly obese females. PLoS One 9 (6):e98244. doi: 10.1371/journal.pone.0098244.
  • Burcelin, R. 2016. Gut microbiota and immune crosstalk in metabolic disease. Molecular Metabolism 5 (9):771–81. doi: 10.1016/j.molmet.2016.05.016.
  • Burkholder-Cooley, N., S. Rajaram, E. Haddad, G. E. Fraser, and K. Jaceldo-Siegl. 2016. Comparison of polyphenol intakes according to distinct dietary patterns and food sources in the Adventist Health Study-2 cohort. The British Journal of Nutrition 115 (12):2162–9. doi: 10.1017/S0007114516001331.
  • Cai, S., W. Sun, Y. Fan, X. Guo, G. Xu, T. Xu, Y. Hou, B. Zhao, X. Feng, and T. Liu. 2016. Effect of mulberry leaf (Folium Mori) on insulin resistance via IRS-1/PI3K/Glut-4 signalling pathway in type 2 diabetes mellitus rats. Pharmaceutical Biology 54 (11):2685–91. doi: 10.1080/13880209.2016.1178779.
  • Camargo, A., J. Ruano, J. M. Fernandez, L. D. Parnell, A. Jimenez, M. Santos-Gonzalez, C. Marin, P. Perez-Martinez, M. Uceda, J. Lopez-Miranda, et al. 2010. Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. BMC Genomics11:253doi: 10.1186/1471-2164-11-253.
  • Camargo, A., O. A. Rangel-Zuniga, C. Haro, E. R. Meza-Miranda, P. Pena-Orihuela, M. E. Meneses, C. Marin, E. M. Yubero-Serrano, P. Perez-Martinez, J. Delgado-Lista, et al. 2014. Olive oil phenolic compounds decrease the postprandial inflammatory response by reducing postprandial plasma lipopolysaccharide levels. Food Chemistry 162:161–71. doi: 10.1016/j.foodchem.2014.04.047.
  • Canto, C.,. Z. Gerhart-Hines, J. N. Feige, M. Lagouge, L. Noriega, J. C. Milne, P. J. Elliott, P. Puigserver, and J. Auwerx. 2009. AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity. Nature458 (7241):1056–60. doi: 10.1038/nature07813.
  • Cao, H., J. Ou, L. Chen, Y. Zhang, T. Szkudelski, D. Delmas, M. Daglia, and J. Xiao. 2019. Dietary polyphenols and type 2 diabetes: Human study and clinical trial. Critical Reviews in Food Science and Nutrition 59 (20):3371–9. doi: 10.1080/10408398.2018.1492900.
  • Carpi, S., E. Scoditti, M. Massaro, B. Polini, C. Manera, M. Digiacomo, J. E. Salsano, G. Poli, T. Tuccinardi, S. Doccini, et al. 2019. The extra-virgin olive oil polyphenols oleocanthal and oleacein counteract inflammation-related gene and miRNA expression in adipocytes by attenuating NF-kappaB activation. Nutrients11 (12):2855. doi: 10.3390/nu11122855.
  • Castro-Barquero, S., R. M. Lamuela-Raventos, M. Domenech, and R. Estruch. 2018. Relationship between Mediterranean dietary polyphenol intake and obesity. Nutrients Relationship Nutrients 10 (10):1523. doi: 10.3390/nu10101523.
  • Chan, C. Y., L. Wei, F. Castro-Munozledo, and W. L. Koo. 2011. (–)-Epigallocatechin-3-gallate blocks 3T3-L1 adipose conversion by inhibition of cell proliferation and suppression of adipose phenotype expression. Life Sciences 89 (21–22):779–85. doi: 10.1016/j.lfs.2011.09.006.
  • Chen, N., R. Bezzina, E. Hinch, P. A. Lewandowski, D. Cameron-Smith, M. L. Mathai, M. Jois, A. J. Sinclair, D. P. Begg, J. D. Wark, et al. 2009. Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutrition Research 29 (11):784–93. doi: 10.1016/j.nutres.2009.10.003.
  • Chen, S., Z. Li, W. Li, Z. Shan, and W. Zhu. 2011. Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK. Canadian Journal of Physiology and Pharmacology 89 (11):793–9. doi: 10.1139/y11-077.
  • Chen, S., X. Xiao, X. Feng, W. Li, N. Zhou, L. Zheng, Y. Sun, Z. Zhang, and W. Zhu. 2012. Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression. The Journal of Nutritional Biochemistry 23 (9):1100–12. doi: 10.1016/j.jnutbio.2011.06.003.
  • Chiva-Blanch, G., and L. Badimon. 2017. Effects of polyphenol intake on metabolic syndrome: Current evidences from human trials. Oxidative Medicine and Cellular Longevity 2017:5812401doi: 10.1155/2017/5812401.
  • Cho, S. Y., P. J. Park, H. J. Shin, Y. K. Kim, D. W. Shin, E. S. Shin, H. H. Lee, B. G. Lee, J. H. Baik, and T. R. Lee. 2007. (–)-Catechin suppresses expression of Kruppel-like factor 7 and increases expression and secretion of adiponectin protein in 3T3-L1 cells. American Journal of Physiology. Endocrinology and Metabolism 292 (4):E1166–72. doi: 10.1152/ajpendo.00436.2006.
  • Chung, J. H., V. Manganiello, and J. R. Dyck. 2012. Resveratrol as a calorie restriction mimetic: Therapeutic implications. Trends in Cell Biology 22 (10):546–54. doi: 10.1016/j.tcb.2012.07.004.
  • Ciccone, M. M., M. F. Faienza, M. Altomare, C. Nacci, M. Montagnani, F. Valente, F. Cortese, M. Gesualdo, A. Zito, R. Mancarella, et al. 2016. Endothelial and metabolic function interactions in overweight/obese children. Journal of Atherosclerosis and Thrombosis 23 (8):950–9. doi: 10.5551/jat.31740.
  • Collaborators G. B. D. D. 2019. Health effects of dietary risks in 195 countries, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet 393:1958–72.
  • Corbo, F., G. Brunetti, P. Crupi, S. Bortolotti, G. Storlino, L. Piacente, A. Carocci, A. Catalano, G. Milani, G. Colaianni, et al. 2019. Effects of sweet cherry polyphenols on enhanced osteoclastogenesis associated with childhood obesity. Front Immunology 10:1001.
  • Cory, H., S. Passarelli, J. Szeto, M. Tamez, and J. Mattei. 2018. The role of polyphenols in human health and food systems: A mini-review. Frontiers in Nutrition 5:87doi: 10.3389/fnut.2018.00087.
  • Costa, C. d S., F. Rohden, T. O. Hammes, R. Margis, J. W. Bortolotto, A. V. Padoin, C. C. Mottin, and R. M. Guaragna. 2011. Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARgamma1-3 mRNA expression in human visceral adipocytes. Obesity Surgery 21 (3):356–61. doi: 10.1007/s11695-010-0251-7.
  • Cox, L. M., and M. J. Blaser. 2013. Pathways in microbe-induced obesity. Cell Metabolism 17 (6):883–94. doi: 10.1016/j.cmet.2013.05.004.
  • D'Amore, S., M. Vacca, M. Cariello, G. Graziano, A. D'Orazio, R. Salvia, R. C. Sasso, C. Sabba, G. Palasciano, and A. Moschetta. 2016. Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil. Biochimica et Biophysica Acta 1861 (11):1671–80. doi: 10.1016/j.bbalip.2016.07.003.
  • D'Archivio, M., C. Filesi, R. Di Benedetto, R. Gargiulo, C. Giovannini, and R. Masella. 2007. Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanita 43:348–61.
  • De Santis, S.,. V. Galleggiante, L. Scandiffio, M. Liso, E. Sommella, A. Sobolewski, V. Spilotro, A. Pinto, P. Campiglia, G. Serino, et al. 2017. Secretory leukoprotease inhibitor (Slpi) expression is required for educating murine dendritic cells inflammatory response following quercetin exposure. Nutrients 9 (7):706. doi: 10.3390/nu9070706.
  • De Santis, S.,. M. Cariello, E. Piccinin, C. Sabba, and A. Moschetta. 2019. Extra virgin olive oil: Lesson from nutrigenomics. Nutrients11 (9):2085. doi: 10.3390/nu11092085.
  • DeFronzo, R. A., E. Ferrannini, L. Groop, R. R. Henry, W. H. Herman, J. J. Holst, F. B. Hu, C. R. Kahn, I. Raz, G. I. Shulman, et al. 2015. Type 2 diabetes mellitus. Nature Reviews. Disease Primers 1:15019doi: 10.1038/nrdp.2015.19.
  • DeFuria J., G. Bennett, K. J. Strissel, J. W. Perfield, P. E. Milbury, A. S. Greenberg and M. S. Obin. 2009. Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. Journal of Nutrition Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae 139:1510–6.
  • Del Rio, D., A. Rodriguez-Mateos, J. P. Spencer, M. Tognolini, G. Borges, and A. Crozier. 2013. Dietary (poly)phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxidants & Redox Signaling 18 (14):1818–92. doi: 10.1089/ars.2012.4581.
  • Do, G. M., U. J. Jung, H. J. Park, E. Y. Kwon, S. M. Jeon, R. A. McGregor, and M. S. Choi. 2012. Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice. Molecular Nutrition & Food Research 56 (8):1282–91. doi: 10.1002/mnfr.201200067.
  • Donmez, G., and L. Guarente. 2010. Aging and disease: Connections to sirtuins. Aging Cell Aging Cell 9 (2):285–90. doi: 10.1111/j.1474-9726.2010.00548.x.
  • Doo, M., and Y. Kim. 2015. Obesity: Interactions of genome and nutrients intake. Preventive Nutrition and Food Science 20 (1):1–7. doi: 10.3746/pnf.2015.20.1.1.
  • Ducheix, S., C. Peres, J. Hardfeldt, C. Frau, G. Mocciaro, E. Piccinin, J. M. Lobaccaro, S. De Santis, M. Chieppa, J. Bertrand-Michel, et al. 2018. Deletion of stearoyl-CoA desaturase-1 from the intestinal epithelium promotes inflammation and tumorigenesis, reversed by dietary oleate. Gastroenterology 155 (5):1524–38 e9. doi: 10.1053/j.gastro.2018.07.032.
  • Ejaz, A., D. Wu, P. Kwan, and M. Meydani. 2009. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. The Journal of Nutrition 139 (5):919–25. doi: 10.3945/jn.108.100966.
  • EUActionPlan2014. EU Action Plan on Childhood Obesity 2014–2020. EU Action Plan on Childhood Obesity 2014–2020
  • Faienza, M. F., N. Santoro, R. Lauciello, R. Calabro, L. Giordani, G. D. Salvo, A. Ventura, M. Delvecchio, L. Perrone, E. M. Del Giudice, et al. 2010. IGF2 gene variants and risk of hypertension in obese children and adolescents. Pediatric Research 67 (4):340–4. doi: 10.1203/PDR.0b013e3181d22757.
  • Faienza, M. F., R. Francavilla, R. Goffredo, A. Ventura, F. Marzano, G. Panzarino, G. Marinelli, L. Cavallo, and G. D. Bitonto. 2012. Oxidative stress in obesity and metabolic syndrome in children and adolescents. Hormone Research in Paediatrics 78 (3):158–64. doi: 10.1159/000342642.
  • Faienza, M. F., A. Acquafredda, R. Tesse, V. Luce, A. Ventura, N. Maggialetti, M. Monteduro, P. Giordano, and L. Cavallo. 2013. Risk factors for subclinical atherosclerosis in diabetic and obese children. International Journal of Medical Sciences 10 (3):338–43. doi: 10.7150/ijms.5181.
  • Faienza, M. F., D. Q. Wang, G. Fruhbeck, G. Garruti, and P. Portincasa. 2016. The dangerous link between childhood and adulthood predictors of obesity and metabolic syndrome. Internal and Emergency Medicine 11 (2):175–82. doi: 10.1007/s11739-015-1382-6.
  • Faienza, M. F., A. Ventura, M. Delvecchio, A. Fusillo, L. Piacente, G. Aceto, G. Colaianni, S. Colucci, L. Cavallo, M. Grano, et al. 2017. High sclerostin and Dickkopf-1 (DKK-1) serum levels in children and adolescents with Type 1 diabetes mellitus. Journal of Clinical Endocrinology & Metabolism 102:1174–81.
  • Faienza, M. F., G. D'Amato, M. Chiarito, G. Colaianni, S. Colucci, M. Grano, F. Corbo, and G. Brunetti. 2019. Mechanisms involved in childhood obesity-related bone fragility. Frontiers in Endocrinology 10:269. doi: 10.3389/fendo.2019.00269.
  • Faienza, M. F., F. Corbo, A. Carocci, A. Catalano, M. L. Clodoveo, M. Grano, D. Q. H. Wang, G. D'Amato, M. Muraglia, C. Franchini, et al. 2020. Novel insights in health-promoting properties of sweet cherries. Journal of Functional Foods69:103945. doi: 10.1016/j.jff.2020.103945.
  • Floyd, Z. E., Z. Q. Wang, G. Kilroy, and W. T. Cefalu. 2008. Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol. Metabolism: Clinical and Experimental 57 (7 Suppl 1):S32–S8. doi: 10.1016/j.metabol.2008.04.006.
  • Fraga, C. G., K. D. Croft, D. O. Kennedy, and F. A. Tomas-Barberan. 2019. The effects of polyphenols and other bioactives on human health. Food & Function 10 (2):514–28. doi: 10.1039/c8fo01997e.
  • Frescas, D., L. Valenti, and D. Accili. 2005. Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. The Journal of Biological Chemistry 280 (21):20589–95. doi: 10.1074/jbc.M412357200.
  • Fulco, M., and V. Sartorelli. 2008. Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. Cell Cycle (Georgetown, Tex.) 7 (23):3669–79. doi: 10.4161/cc.7.23.7164.
  • Fullerton, M. D., and G. R. Steinberg. 2010. SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol. Diabetes 59 (3):551–3. doi: 10.2337/db09-1732.
  • Galleggiante, V., S. De Santis, M. Liso, G. Verna, E. Sommella, M. Mastronardi, P. Campiglia, M. Chieppa, and G. Serino. 2019. Quercetin-induced miR-369-3p suppresses chronic inflammatory response targeting C/EBP-β . Molecular Nutrition & Food Research 63 (19):e1801390doi: 10.1002/mnfr.201801390.
  • Gerhart-Hines, Z., J. T. Rodgers, O. Bare, C. Lerin, S. H. Kim, R. Mostoslavsky, F. W. Alt, Z. Wu, and P. Puigserver. 2007. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. The EMBO Journal 26 (7):1913–23. doi: 10.1038/sj.emboj.7601633.
  • Gonzales, A. M., and R. A. Orlando. 2008. Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutrition & Metabolism 5:17doi: 10.1186/1743-7075-5-17.
  • Han, X., T. Shen, and H. Lou. 2007. Dietary polyphenols and their biological significance. International Journal of Molecular Sciences 8 (9):950–88. doi: 10.3390/i8090950.
  • Hao, J., W. Shen, G. Yu, H. Jia, X. Li, Z. Feng, Y. Wang, P. Weber, K. Wertz, E. Sharman, et al. 2010. Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes. The Journal of Nutritional Biochemistry 21 (7):634–44. doi: 10.1016/j.jnutbio.2009.03.012.
  • Harp, J. B. 2004. New insights into inhibitors of adipogenesis. Current Opinion in Lipidology 15 (3):303–7. doi: 10.1097/00041433-200406000-00010.
  • He, W., Y. Barak, A. Hevener, P. Olson, D. Liao, J. Le, M. Nelson, E. Ong, J. M. Olefsky, and R. M. Evans. 2003. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proceedings of the National Academy of Sciences of the United States of America 100 (26):15712–7. doi: 10.1073/pnas.2536828100.
  • Hou, X., S. Xu, K. A. Maitland-Toolan, K. Sato, B. Jiang, Y. Ido, F. Lan, K. Walsh, M. Wierzbicki, T. J. Verbeuren, et al. 2008. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. The Journal of Biological Chemistry 283 (29):20015–26. doi: 10.1074/jbc.M802187200.
  • Huang, J., Y. Wang, Z. Xie, Y. Zhou, Y. Zhang, and X. Wan. 2014. The anti-obesity effects of green tea in human intervention and basic molecular studies. European Journal of Clinical Nutrition 68 (10):1075–87. doi: 10.1038/ejcn.2014.143.
  • Humbyrd, C. J. 2018. Complex Obesity: Multifactorial Etiologies and Multifaceted Responses. The American Journal of Bioethics: AJOB 18 (7):87–9. doi: 10.1080/15265161.2018.1478042.
  • Hung, P. F., B. T. Wu, H. C. Chen, Y. H. Chen, C. L. Chen, M. H. Wu, H. C. Liu, M. J. Lee, and Y. H. Kao. 2005. Antimitogenic effect of green tea (–)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the ERK and Cdk2 pathways. American Journal of Physiology. Cell Physiology 288 (5):C1094–108. doi: 10.1152/ajpcell.00569.2004.
  • Ivanov, V. N., M. A. Partridge, G. E. Johnson, S. X. Huang, H. Zhou, and T. K. Hei. 2008. Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Experimental Cell Research 314 (5):1163–76. doi: 10.1016/j.yexcr.2007.12.012.
  • Jaacks, L. M., S. Vandevijvere, A. Pan, C. J. McGowan, C. Wallace, F. Imamura, D. Mozaffarian, B. Swinburn, and M. Ezzati. 2019. The obesity transition: Stages of the global epidemic. The Lancet. Diabetes & Endocrinology 7 (3):231–40. doi: 10.1016/S2213-8587(19)30026-9.
  • Kalupahana, N. S., N. Moustaid-Moussa, and K. J. Claycombe. 2012. Immunity as a link between obesity and insulin resistance. Molecular Aspects of Medicine 33 (1):26–34. doi: 10.1016/j.mam.2011.10.011.
  • Kang, G. G., N. Francis, R. Hill, D. Waters, C. Blanchard, and A. B. Santhakumar. 2019. Dietary polyphenols and gene expression in molecular pathways associated with Type 2 diabetes mellitus: A review. International Journal of Molecular Sciences 21. doi: 10.3390/ijms21010140.
  • Kang I., J. C. Espin, T. P. Carr, F. A. Tomas-Barberan and S. Chung. 2016. Raspberry seed flour attenuates high-sucrose diet-mediated hepatic stress and adipose tissue inflammation. Journal of Nutrition Biochem Raspberry seed flour attenuates high-sucrose diet-mediated hepatic stress and adipose tissue inflammation 32:64–72.
  • Kang, L., W. Heng, A. Yuan, L. Baolin, and H. Fang. 2010. Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes: Relative to inhibition of inflammatory responses. Biochimie 92 (7):789–96. doi: 10.1016/j.biochi.2010.02.024.
  • Kershaw, E. E., and J. S. Flier. 2004. Adipose tissue as an endocrine organ. The Journal of Clinical Endocrinology and Metabolism 89 (6):2548–56. doi: 10.1210/jc.2004-0395.
  • Kim, C. Y., T. T. Le, C. Chen, J. X. Cheng, and K. H. Kim. 2011a. Curcumin inhibits adipocyte differentiation through modulation of mitotic clonal expansion. The Journal of Nutritional Biochemistry 22 (10):910–20. doi: 10.1016/j.jnutbio.2010.08.003.
  • Kim, H., A. Hiraishi, K. Tsuchiya, and K. Sakamoto. 2010. (–) Epigallocatechin gallate suppresses the differentiation of 3T3-L1 preadipocytes through transcription factors FoxO1 and SREBP1c. Cytotechnology62 (3):245–55. doi: 10.1007/s10616-010-9285-x.
  • Kim, S., Y. Jin, Y. Choi, and T. Park. 2011b. Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice. Biochemical Pharmacology 81 (11):1343–51. doi: 10.1016/j.bcp.2011.03.012.
  • Klaus, S., S. Pultz, C. Thone-Reineke, and S. Wolfram. 2005. Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation. International Journal of Obesity (2005) 29 (6):615–23. doi: 10.1038/sj.ijo.0802926.
  • Kudo, N., Y. Arai, Y. Suhara, T. Ishii, T. Nakayama, and N. Osakabe. 2015. A single oral administration of theaflavins increases energy expenditure and the expression of metabolic genes. PLoS One 10 (9):e0137809doi: 10.1371/journal.pone.0137809.
  • Kumar Singh, A., C. Cabral, R. Kumar, R. Ganguly, H. Kumar Rana, A. Gupta, M. Rosaria Lauro, C. Carbone, F. Reis, and A. K. Pandey. 2019. Beneficial effects of dietary polyphenols on gut microbiota and strategies to improve delivery efficiency. Nutrients11 (9):2216. doi: 10.3390/nu11092216.
  • Kwon, J. Y., S. G. Seo, S. Yue, J. X. Cheng, K. W. Lee, and K. H. Kim. 2012. An inhibitory effect of resveratrol in the mitotic clonal expansion and insulin signaling pathway in the early phase of adipogenesis. Nutrition Research (New York, N.Y.) 32 (8):607–16. doi: 10.1016/j.nutres.2012.06.014.
  • Lagouge, M., C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, et al. 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell Resveratrol127 (6):1109–22. doi: 10.1016/j.cell.2006.11.013.
  • Lan, F., J. M. Cacicedo, N. Ruderman, and Y. Ido. 2008. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. The Journal of Biological Chemistry 283 (41):27628–35. doi: 10.1074/jbc.M805711200.
  • Lasa, A., M. Schweiger, P. Kotzbeck, I. Churruca, E. Simon, R. Zechner, and M. P. Portillo. 2012. Resveratrol regulates lipolysis via adipose triglyceride lipase. The Journal of Nutritional Biochemistry 23 (4):379–84. doi: 10.1016/j.jnutbio.2010.12.014.
  • Lee, M. S., C. T. Kim, I. H. Kim, and Y. Kim. 2009a. Inhibitory effects of green tea catechin on the lipid accumulation in 3T3-L1 adipocytes. Phytotherapy Research : PTR 23 (8):1088–91. doi: 10.1002/ptr.2737.
  • Lee, M. S., C. T. Kim, and Y. Kim. 2009b. Green tea (–)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice. Annals of Nutrition and Metabolism 54 (2):151–7. doi: 10.1159/000214834.
  • Lee, M. S., and Y. Kim. 2009c. (–)-Epigallocatechin-3-gallate enhances uncoupling protein 2 gene expression in 3T3-L1 adipocytes. Bioscience, Biotechnology, and Biochemistry 73 (2):434–6. doi: 10.1271/bbb.80563.
  • Lee, M. S., Y. Shin, S. Jung, and Y. Kim. 2017. Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of diet-induced obese mice. Food & Nutrition Research 61 (1):1325307doi: 10.1080/16546628.2017.1325307.
  • Lee, Y. K., W. S. Lee, J. T. Hwang, D. Y. Kwon, Y. J. Surh, and O. J. Park. 2009d. Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells. Journal of Agricultural and Food Chemistry 57 (1):305–10. doi: 10.1021/jf802737z.
  • Lee, Y. S., J. Wollam, and J. M. Olefsky. 2018. An integrated view of immunometabolism. Cell 172 (1-2):22–40. doi: 10.1016/j.cell.2017.12.025.
  • Lin, S. C., and D. G. Hardie. 2018. AMPK: Sensing glucose as well as cellular energy status. Cell Metabolism 27 (2):299–313. doi: 10.1016/j.cmet.2017.10.009.
  • Liu, H. S., Y. H. Chen, P. F. Hung, and Y. H. Kao. 2006. Inhibitory effect of green tea (–)-epigallocatechin gallate on resistin gene expression in 3T3-L1 adipocytes depends on the ERK pathway. American Journal of Physiology. Endocrinology and Metabolism 290 (2):E273–81. doi: 10.1152/ajpendo.00325.2005.
  • Liu, X., H. Zhao, Q. Jin, W. You, H. Cheng, Y. Liu, E. Song, G. Liu, X. Tan, X. Zhang, et al. 2018. Resveratrol induces apoptosis and inhibits adipogenesis by stimulating the SIRT1-AMPKα-FOXO1 signalling pathway in bovine intramuscular adipocytes . Molecular and Cellular Biochemistry 439 (1–2):213–23. doi: 10.1007/s11010-017-3149-z.
  • Lu C., W. Zhu, C. L. Shen and W. Gao. 2012. Green tea polyphenols reduce body weight in rats by modulating obesity-related genes. PLoS One Green tea polyphenols reduce body weight in rats by modulating obesity-related genes 7:e38332. doi: 10.1371/journal.pone.0038332.
  • Lumeng, C. N., J. L. Bodzin, and A. R. Saltiel. 2007. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. The Journal of Clinical Investigation 117 (1):175–84. doi: 10.1172/JCI29881.
  • Magrone, T., and E. Jirillo. 2015. Childhood obesity: Immune response and nutritional approaches. Frontiers in Immunology 6:76doi: 10.3389/fimmu.2015.00076.
  • Manach, C., G. Williamson, C. Morand, A. Scalbert, and C. Remesy. 2005. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. The American Journal of Clinical Nutrition 81 (1 Suppl):230S–42S. doi: 10.1093/ajcn/81.1.230S.
  • Marin, L., E. M. Miguelez, C. J. Villar, and F. Lombo. 2015. Bioavailability of dietary polyphenols and gut microbiota metabolism: Antimicrobial properties. BioMed Research International 2015:905215doi: 10.1155/2015/905215.
  • Marzano, F., M. F. Faienza, M. F. Caratozzolo, G. Brunetti, M. Chiara, D. S. Horner, A. Annese, A. M. D'Erchia, A. Consiglio, G. Pesole, et al. 2018. Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age. Pediatric Obesity 13 (12):803–11. doi: 10.1111/ijpo.12439.
  • Mathis, D. 2013. Immunological goings-on in visceral adipose tissue. Cell Metabolism 17 (6):851–9. doi: 10.1016/j.cmet.2013.05.008.
  • Mele, L., G. Bidault, P. Mena, A. Crozier, F. Brighenti, A. Vidal-Puig, and D. Del Rio. 2017. Dietary (poly)phenols, brown adipose tissue activation, and energy expenditure: A narrative review. Advances in Nutrition: An International Review Journal 8 (5):694–704. doi: 10.3945/an.117.015792.
  • Mennen, L. I., R. Walker, C. Bennetau-Pelissero, and A. Scalbert. 2005. Risks and safety of polyphenol consumption. The American Journal of Clinical Nutrition 81 (1 Suppl):326S–9S. doi: 10.1093/ajcn/81.1.326S.
  • Meydani, M., and S. T. Hasan. 2010. Dietary polyphenols and obesity. Nutrients 2 (7):737–51. doi: 10.3390/nu2070737.
  • Miniello, V. L., M. F. Faienza, P. Scicchitano, F. Cortese, M. Gesualdo, A. Zito, M. Basile, P. Recchia, D. Leogrande, D. Viola, et al. 2014. Insulin resistance and endothelial function in children and adolescents. International Journal of Cardiology 174 (2):343–7. doi: 10.1016/j.ijcard.2014.04.115.
  • Monika P. and A. Geetha. 2015. The modulating effect of Persea americana fruit extract on the level of expression of fatty acid synthase complex, lipoprotein lipase, fibroblast growth factor-21 and leptin – A biochemical study in rats subjected to experimental hyperlipidemia and obesity. Phytomedicine The modulating effect of Persea americana fruit extract on the level of expression of fatty acid synthase complex, lipoprotein lipase, fibroblast growth factor-21 and leptin – A biochemical study in rats subjected to experimental hyperlipidemia and obesity 22:939–45.
  • Most, J., I. Warnke, M. V. Boekschoten, J. W. E. Jocken, P. de Groot, A. Friedel, I. Bendik, G. H. Goossens, and E. E. Blaak. 2018. The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans. Adipocyte7 (3):190–6. doi: 10.1080/21623945.2018.1469942.
  • Nacci, C., V. Leo, L. De Benedictis, M. R. Carratu, N. Bartolomeo, M. Altomare, P. Giordano, M. F. Faienza, and M. Montagnani. 2013. Elevated endothelin-1 (ET-1) levels may contribute to hypoadiponectinemia in childhood obesity. The Journal of Clinical Endocrinology & Metabolism 98 (4):E683–93. doi: 10.1210/jc.2012-4119.
  • Nagao, K., T. Jinnouchi, S. Kai, and T. Yanagita. 2013. Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats. Lipids in Health and Disease 12:8doi: 10.1186/1476-511X-12-8.
  • O'Neill, H. M., G. P. Holloway, and G. R. Steinberg. 2013. AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity. Molecular and Cellular Endocrinology 366 (2):135–51. doi: 10.1016/j.mce.2012.06.019.
  • Odegaard, J. I., and A. Chawla. 2011. Alternative macrophage activation and metabolism. Annual Review of Pathology 6:275–97. doi: 10.1146/annurev-pathol-011110-130138.
  • Olholm, J., S. K. Paulsen, K. B. Cullberg, B. Richelsen, and S. B. Pedersen. 2010. Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants. International Journal of Obesity 34 (10):1546–53. doi: 10.1038/ijo.2010.98.
  • Ooi, J., H. A. Adamu, M. U. Imam, H. Ithnin, and M. Ismail. 2018. Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 98:125–33. doi: 10.1016/j.biopha.2017.12.002.
  • Ordovas, J. M., L. R. Ferguson, E. S. Tai, and J. C. Mathers. 2018. Personalised nutrition and health. British Medical Journal 361:2173. doi: 10.1136/bmj.k2173.
  • Ottaviani, J. I., G. Borges, T. Y. Momma, J. P. Spencer, C. L. Keen, A. Crozier, and H. Schroeter. 2016. The metabolome of [2-(14)C](–)-epicatechin in humans: Implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives. Scientific Reports 6 (1):29034. doi: 10.1038/srep29034.
  • Paipilla, A. T-d A. C., J. J. Cruz-Sanchez, H. Castro, E. Poveda-Espinosa, A. Camacho, and A. L. de la Garza. 2016. Effect of dietary interventions in the gene expression involved in molecular mechanisms of obesity: Evidence-based translational research from clinical trials. EC Nutrition 5:1255–65.
  • Park, H. J., D. A. DiNatale, M. Y. Chung, Y. K. Park, J. Y. Lee, S. I. Koo, M. O'Connor, J. E. Manautou, and R. S. Bruno. 2011. Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. The Journal of Nutritional Biochemistry 22 (4):393–400. doi: 10.1016/j.jnutbio.2010.03.009.
  • Pena-Romero, A. C., D. Navas-Carrillo, F. Marin, and E. Orenes-Pinero. 2018. The future of nutrition: Nutrigenomics and nutrigenetics in obesity and cardiovascular diseases. Critical Reviews in Food Science and Nutrition 58 (17):3030–41. doi: 10.1080/10408398.2017.1349731.
  • Peyrol, J., C. Riva, and M. J. Amiot. 2017. Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders. Nutrients9 (3):306. doi: 10.3390/nu9030306.
  • Pinto, P., and C. N. Santos. 2017. Worldwide (poly)phenol intake: Assessment methods and identified gaps. European Journal of Nutrition 56 (4):1393–408. doi: 10.1007/s00394-016-1354-2.
  • Poddar, K., S. Kolge, L. Bezman, G. E. Mullin, and L. J. Cheskin. 2011. Nutraceutical supplements for weight loss: A systematic review. Nutrition in Clinical Practice: Official Publication of the American Society for Parenteral and Enteral Nutrition 26 (5):539–52. doi: 10.1177/0884533611419859.
  • Qiao, L., and J. Shao. 2006. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. The Journal of Biological Chemistry 281 (52):39915–24. doi: 10.1074/jbc.M607215200.
  • Radler, U., H. Stangl, S. Lechner, G. Lienbacher, R. Krepp, E. Zeller, M. Brachinger, D. Eller-Berndl, A. Fischer, C. Anzur, et al. 2011. A combination of (omega-3) polyunsaturated fatty acids, polyphenols and L-carnitine reduces the plasma lipid levels and increases the expression of genes involved in fatty acid oxidation in human peripheral blood mononuclear cells and HepG2 cells. Annals of Nutrition and Metabolism 58 (2):133–40. doi: 10.1159/000327150.
  • Rayalam, S., J. Y. Yang, S. Ambati, M. A. Della-Fera, and C. A. Baile. 2008. Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. Phytotherapy Research 22 (10):1367–71. doi: 10.1002/ptr.2503.
  • Renaud, J., and M. G. Martinoli. 2019. Considerations for the use of polyphenols as therapies in neurodegenerative diseases. International Journal of Molecular Sciences 20. doi :10.3390/ijms20081883.
  • Ridaura, V. K., J. J. Faith, F. E. Rey, J. Cheng, A. E. Duncan, A. L. Kau, N. W. Griffin, V. Lombard, B. Henrissat, J. R. Bain, et al. 2013. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (New York, N.Y.) 341 (6150):1241214 doi: 10.1126/science.1241214.
  • Riva, A., F. Borgo, C. Lassandro, E. Verduci, G. Morace, E. Borghi, and D. Berry. 2017. Pediatric obesity is associated with an altered gut microbiota and discordant shifts in Firmicutes populations. Environmental Microbiology 19 (1):95–105. doi: 10.1111/1462-2920.13463.
  • Rodgers, J. T., C. Lerin, W. Haas, S. P. Gygi, B. M. Spiegelman, and P. Puigserver. 2005. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 (7029):113–8. doi: 10.1038/nature03354.
  • Roopchand, D. E., R. N. Carmody, P. Kuhn, K. Moskal, P. Rojas-Silva, P. J. Turnbaugh, and I. Raskin. 2015. Dietary polyphenols promote growth of the gut bacterium Akkermansia muciniphila and attenuate high-fat diet-induced metabolic syndrome. Diabetes64 (8):2847–58. doi: 10.2337/db14-1916.
  • Roth, C. L., M. Kratz, M. M. Ralston, and T. Reinehr. 2011. Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children. Metabolism 60 (4):445–52. doi: 10.1016/j.metabol.2010.03.023.
  • Sanchez, J.,. T. Priego, C. Pico, W. Ahrens, S. De Henauw, A. Fraterman, S. Marild, D. Molnar, L. A. Moreno, J. Peplies, et al. 2012. Blood cells as a source of transcriptional biomarkers of childhood obesity and its related metabolic alterations: Results of the IDEFICS study. The Journal of Clinical Endocrinology and Metabolism 97 (4):E648–52. doi: 10.1210/jc.2011-2209.
  • Scherer, P. E. 2006. Adipose tissue: From lipid storage compartment to endocrine organ. Diabetes55 (6):1537–45. doi: 10.2337/db06-0263.
  • Schilter, B.,. C. Andersson, R. Anton, A. Constable, J. Kleiner, J. O'Brien, A. G. Renwick, O. Korver, F. Smit, and R. Walker. 2003. Guidance for the safety assessment of botanicals and botanical preparations for use in food and food supplements. Food and Chemical Toxicology: Toxicology 41 (12):1625–49. doi: 10.1016/S0278-6915(03)00221-7.
  • Scoditti, E., S. Carpi, M. Massaro, M. Pellegrino, B. Polini, M. A. Carluccio, M. Wabitsch, T. Verri, P. Nieri, and R. D. Caterina. 2019. Hydroxytyrosol modulates adipocyte gene and miRNA expression under inflammatory condition. Nutrients 11 (10):2493. doi: 10.3390/nu11102493.
  • Serreli, G., and M. Deiana. 2019. In vivo formed metabolites of polyphenols and their biological efficacy. Food & Function 10 (11):6999–7021. doi: 10.1039/c9fo01733j.
  • Singer, K., and C. N. Lumeng. 2017. The initiation of metabolic inflammation in childhood obesity. The Journal of Clinical Investigation 127 (1):65–73. doi: 10.1172/JCI88882.
  • Spencer, J. P., M. M. Abd El Mohsen, A. M. Minihane, and J. C. Mathers. 2008. Biomarkers of the intake of dietary polyphenols: Strengths, limitations and application in nutrition research. The British Journal of Nutrition 99 (1):12–22. doi: 10.1017/S0007114507798938.
  • Torabi, S., and N. M. DiMarco. 2016. Original research: Polyphenols extracted from grape powder induce lipogenesis and glucose uptake during differentiation of murine preadipocytes. Experimental Biology and Medicine (Maywood, N.J.) 241 (16):1776–85. doi: 10.1177/1535370216645213.
  • Tsao, R. 2010. Chemistry and biochemistry of dietary polyphenols. Nutrients 2 (12):1231–46. doi: 10.3390/nu2121231.
  • Tsuda, T.,. Y. Ueno, T. Yoshikawa, H. Kojo, and T. Osawa. 2006. Microarray profiling of gene expression in human adipocytes in response to anthocyanins. Biochemical Pharmacology 71 (8):1184–97. doi: 10.1016/j.bcp.2005.12.042.
  • Venkatakrishnan, K., H. F. Chiu, and C. K. Wang. 2019. Extensive review of popular functional foods and nutraceuticals against obesity and its related complications with a special focus on randomized clinical trials. Food & Function 10 (5):2313–29. doi: 10.1039/c9fo00293f.
  • Visioli, F., C. A. De La Lastra, C. Andres-Lacueva, M. Aviram, C. Calhau, A. Cassano, M. D'Archivio, A. Faria, G. Fave, V. Fogliano, et al. 2011. Polyphenols and human health: A prospectus. Critical Reviews in Food Science and Nutrition 51 (6):524–46. doi: 10.1080/10408391003698677.
  • Walker, C. G., M. G. Zariwala, M. J. Holness, and M. C. Sugden. 2007. Diet, obesity and diabetes: A current update. Clinical Science (London, England : 1979) 112 (2):93–111. doi: 10.1042/CS20060150.
  • Wang, S., N. Moustaid-Moussa, L. Chen, H. Mo, A. Shastri, R. Su, P. Bapat, I. Kwun, and C. L. Shen. 2014. Novel insights of dietary polyphenols and obesity. The Journal of Nutritional Biochemistry 25 (1):1–18. doi: 10.1016/j.jnutbio.2013.09.001.
  • Wang, S. L., Y. Li, Y. Wen, Y. F. Chen, L. X. Na, S. T. Li, and C. H. Sun. 2009. Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway. Biomedical and Environmental Sciences : BES 22 (1):32–9. doi: 10.1016/S0895-3988(09)60019-2.
  • Wang, Y., and L. V. Hooper. 2019. Immune control of the microbiota prevents obesity. Science (New York, N.Y.) 365 (6451):316–7. doi: 10.1126/science.aay2057.
  • Weihrauch-Bluher, S., P. Schwarz, and J. H. Klusmann. 2019. Childhood obesity: Increased risk for cardiometabolic disease and cancer in adulthood. Metabolism: clinical and Experimental 92:147–52. doi: 10.1016/j.metabol.2018.12.001.
  • Weisberg, S. P., R. Leibel, and D. V. Tortoriello. 2008. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology Dietary Endocrinology 149 (7):3549–58. doi: 10.1210/en.2008-0262.
  • WHO. 2018. Childhood overweight and obesity. Copenhagen, Denmark: WHO Regional Office for Europe UN City.
  • Wolfram, S., D. Raederstorff, Y. Wang, S. R. Teixeira, V. Elste, and P. Weber. 2005. TEAVIGO (epigallocatechin gallate) supplementation prevents obesity in rodents by reducing adipose tissue mass. Annals of Nutrition and Metabolism 49 (1):54–63. doi: 10.1159/000084178.
  • Wu, T., Q. Tang, Z. Gao, Z. Yu, H. Song, X. Zheng, and W. Chen. 2013. Blueberry and mulberry juice prevent obesity development in C57BL/6 mice. PLoS One 8 (10):e77585doi: 10.1371/journal.pone.0077585.
  • Yamaguchi, S., H. Katahira, S. Ozawa, Y. Nakamichi, T. Tanaka, T. Shimoyama, K. Takahashi, K. Yoshimoto, M. O. Imaizumi, S. Nagamatsu, et al. 2005. Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes. American Journal of Physiology. Endocrinology and Metabolism 289 (4):E643–9. doi: 10.1152/ajpendo.00456.2004.
  • Zhang, H. Y., Z. X. Du, and X. Meng. 2013. Resveratrol prevents TNFα-induced suppression of adiponectin expression via PPARγ activation in 3T3-L1 adipocytes. Clinical and Experimental Medicine 13 (3):193–9. doi: 10.1007/s10238-012-0189-2.
  • Zhang, X. H., B. Huang, S. K. Choi, and J. S. Seo. 2012. Anti-obesity effect of resveratrol-amplified grape skin extracts on 3T3-L1 adipocytes differentiation. Nutrition Research and Practice 6 (4):286–93. doi: 10.4162/nrp.2012.6.4.286.
  • Zhang, Z.,. H. Zhang, B. Li, X. Meng, J. Wang, Y. Zhang, S. Yao, Q. Ma, L. Jin, J. Yang, et al. 2014. Berberine activates thermogenesis in white and brown adipose tissue. Nature Communications 5:5493doi: 10.1038/ncomms6493.
  • Zhao, J., X. B. Sun, F. Ye, and W. X. Tian. 2011. Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin. Molecular and Cellular Biochemistry 351 (1-2):19–28. doi: 10.1007/s11010-010-0707-z.
  • Zhu, J., W. Yong, X. Wu, Y. Yu, J. Lv, C. Liu, X. Mao, Y. Zhu, K. Xu, X. Han, et al. 2008. Anti-inflammatory effect of resveratrol on TNF-alpha-induced MCP-1 expression in adipocytes. Biochemical and Biophysical Research Communications 369 (2):471–7. doi: 10.1016/j.bbrc.2008.02.034.

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