Mycotoxins in food: a review on liquid chromatographic methods coupled to mass spectrometry and their experimental designs

References

• Alcántara-Durán, J., D. Moreno-González, J. F. García-Reyes, and A. Molina-Díaz. 2019. Use of a modified QuEChERS method for the determination of mycotoxin residues in edible nuts by nano flow liquid chromatography high resolution mass spectrometry. Food Chemistry 279:144–9. doi: 10.1016/j.foodchem.2018.11.149.
   PubMed Web of Science ®Google Scholar
• Alsharif, A. M. A., Y. M. Choo, G. H. Tan, and L. B. Abdulra’uf. 2019. Determination of mycotoxins using hollow fiber dispersive liquid–liquid–microextraction (HF-DLLME) prior to high-performance liquid chromatography–tandem mass spectrometry (HPLC - MS/MS.). Analytical Letters 52 (12):1976–90. doi: 10.1080/00032719.2019.1587766.
   Web of Science ®Google Scholar
• Amirahmadi, M., S. Shoeibi, H. Rastegar, M. Elmi, and A. Mousavi Khaneghah. 2018. Simultaneous analysis of mycotoxins in corn flour using LC/MS-MS combined with a modified QuEChERS procedure. Toxin Reviews 37 (3):187–95. doi: 10.1080/15569543.2017.1354306.
   Web of Science ®Google Scholar
• Arroyo-Manzanares, N., A. M. García-Campaña, and L. Gámiz-Gracia. 2013. Multiclass mycotoxin analysis in Silybum marianum by ultra high performance liquid chromatography-tandem mass spectrometry using a procedure based on QuEChERS and dispersive liquid-liquid microextraction. Journal of Chromatography A 1282:11–19. doi: 10.1016/j.chroma.2013.01.072.
   PubMed Web of Science ®Google Scholar
• Arroyo-Manzanares, N., J. F. Huertas-Pérez, L. Gámiz-Gracia, and A. M. García-Campaña. 2013. A new approach in sample treatment combined with UHPLC-MS/MS for the determination of multiclass mycotoxins in edible nuts and seeds. Talanta 115:61–7. doi: 10.1016/j.talanta.2013.04.024.
   PubMed Web of Science ®Google Scholar
• Azaiez, I., F. Giusti, G. Sagratini, J. Mañes, and M. Fernández-Franzón. 2014. Multi-mycotoxins analysis in dried fruit by LC/MS/MS and a modified QuEChERS procedure. Food Analytical Methods 7 (4):935–45. doi: 10.1007/s12161-013-9785-3.
   Web of Science ®Google Scholar
• Barthel, J., C. Gottschalk, M. Rapp, M. Berger, J. Bauer, and K. Meyer. 2012. Occurrence of type A, B and D trichothecenes in barley and barley products from the Bavarian market. Mycotoxin Research (2)28:97–106. doi: 10.1007/s12550-012-0123-1.
   PubMedGoogle Scholar
• Beltrán, E., M. Ibáñez, J. V. Sancho, M. Á. Cortés, V. Yus, and F. Hernández. 2011. UHPLC-MS/MS highly sensitive determination of aflatoxins, the aflatoxin metabolite M1 and ochratoxin A in baby food and milk. Food Chemistry (2)126:737–44. doi: 10.1016/j.foodchem.2010.11.056.
   Web of Science ®Google Scholar
• Beltrán, E., M. Ibáñez, J. V. Sancho, and F. Hernández. 2014. Determination of patulin in apple and derived products by UHPLC-MS/MS. Study of matrix effects with atmospheric pressure ionisation sources. Food Chemistry 142:400–7. doi: 10.1016/j.foodchem.2013.07.069.
   PubMed Web of Science ®Google Scholar
• Berger, U., M. Oehme, and F. Kuhn. 1999. Quantitative determination and structure elucidation of type A- and B-trichothecenes by HPLC/ion trap multiple mass spectrometry. Journal of Agricultural and Food Chemistry 47 (10):4240–5. doi: 10.1021/jf9904012.
   PubMed Web of Science ®Google Scholar
• Berthiller, F., R. Schuhmacher, G. Buttinger, and R. Krska. 2005. Rapid simultaneous determination of major type A- and B-trichothecenes as well as zearalenone in maize by high performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography A (2)1062:209–16. doi: 10.1016/j.chroma.2004.11.011.
   PubMed Web of Science ®Google Scholar
• Biancardi, A., and A. Riberzani. 1996. Determination of ochratoxin A in cereals and feed by SAX-SPE clean up and LC fluorimetric detection. Journal of Liquid Chromatography and Related Technologies 19 (15):2395–407. doi: 10.1080/10826079608014025.
   Web of Science ®Google Scholar
• Campone, L., A. L. Piccinelli, R. Celano, M. Russo, A. Valdés, C. Ibáñez, and L. Rastrelli. 2015. A fully automated method for simultaneous determination of aflatoxins and ochratoxin A in dried fruits by pressurized liquid extraction and online solid-phase extraction cleanup coupled to ultra-high-pressure liquid chromatography – tandem mass spectromet. Analytical and Bioanalytical Chemistry (10)407:2899–911. doi: 10.1007/s00216-015-8518-4.
   PubMed Web of Science ®Google Scholar
• Cappiello, A., G. Famiglini, and B. Tirillini. 1995. Determination of aflatoxins in peanut meal by LC/MS with a particle beam interface. Chromatographia 40 (7–8):411–16. doi: 10.1007/BF02269904.
   Web of Science ®Google Scholar
• Caputo, D., G. D. Cesare, A. Nascetti, R. Scipinotti, F. Pavanello, and R. Arrigoni. 2014. DEMOCHEM : integrated system for mycotoxins detection. Procedia Engineering 87:1354–7. doi: 10.1016/j.proeng.2014.11.719.
   Google Scholar
• Cavaliere, C., P. Foglia, C. Guarino, M. Nazzari, R. Samperi, and A. Laganà. 2007. Determination of aflatoxins in olive oil by liquid chromatography-tandem mass spectrometry. Analytica Chimica Acta 596 (1):141–8. doi: 10.1016/j.aca.2007.05.055.
   PubMed Web of Science ®Google Scholar
• Cavaliere, C., P. Foglia, E. Pastorini, R., Samperi, and A. Laganà. 2006. Liquid chromatography/tandem mass spectrometric confirmatory method for determining aflatoxin M1 in cow milk: Comparison between electrospray and atmospheric pressure photoionization sources. Journal of Chromatography A (1–2)1101:69–78. doi: 10.1016/j.chroma.2005.09.060.
   PubMed Web of Science ®Google Scholar
• Commission Regulation (EC). 2006. Commission regulation (EC) no. 1881/2006. Official Journal of the European Union, L 364/5-24.
   Google Scholar
• Commission Regulation (EC). 2010. Commission regulation (EU) no. 105/2010. Official Journal of European Union, L 35/7-8.
   Google Scholar
• De Boevre, M., J. D. Di Mavungu, P. Maene, K. Audenaert, D. Deforce, G. Haesaert, M. Eeckhout, A. Callebaut, F. Berthiller, C. Van Peteghem, et al. 2012. Development and validation of an LC-MS/MS method for the simultaneous determination of deoxynivalenol, zearalenone, T-2-toxin and some masked metabolites in different cereals and cereal-derived food. Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure & Risk Assessment 29 (5):819–35. doi: 10.1080/19440049.2012.656707.
   PubMed Web of Science ®Google Scholar
• De Santis, B., F. Debegnach, E. Gregori, S. Russo, F. Marchegiani, G., Moracci, and C. Brera. 2017. Development of a LC-MS/MS method for the multi-mycotoxin determination in composite cereal-based samples. Toxins 9 (5):169. doi: 10.3390/toxins9050169.
   Web of Science ®Google Scholar
• Desmarchelier, A., S. Tessiot, T. Bessaire, L. Racault, E. Fiorese, A. Urbani, W.-C. Chan, P. Cheng, and P. Mottier. 2014. Combining the quick, easy, cheap, effective, rugged and safe approach and clean-up by immunoaffinity column for the analysis of 15 mycotoxins by isotope dilution liquid chromatography tandem mass spectrometry. Journal of Chromatography A 1337:75–84. doi: 10.1016/j.chroma.2014.02.025.
   PubMed Web of Science ®Google Scholar
• Diana Di Mavungu, J., S. Monbaliu, M.-L. Scippo, G. Maghuin-Rogister, Y.-J. Schneider, Y. Larondelle, A. Callebaut, J. Robbens, C. Van Peteghem, and S. De Saeger. 2009. LC-MS/MS multi-analyte method for mycotoxin determination in food supplements. Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure & Risk Assessment 26 (6):885–95. doi: 10.1080/02652030902774649.
   PubMed Web of Science ®Google Scholar
• Dias, J. V., R. C. da Silva, I. R. Pizzutti, I. D. dos Santos, M. Dassi, and C. D. Cardoso. 2019. Patulin in apple and apple juice: Method development, validation by liquid chromatography-tandem mass spectrometry and survey in Brazilian south supermarkets. Journal of Food Composition and Analysis 82:103242. doi: 10.1016/j.jfca.2019.103242.
   Web of Science ®Google Scholar
• Dong, H., Y. Xian, K. Xiao, Y. Wu, L. Zhu, and J. He. 2019. Development and comparison of single-step solid phase extraction and QuEChERS clean-up for the analysis of 7 mycotoxins in fruits and vegetables during storage by UHPLC-MS/MS. Food Chemistry 274:471–9. doi: 10.1016/j.foodchem.2018.09.035.
   PubMed Web of Science ®Google Scholar
• Dong, M., W. Si, K. Jiang, D. Nie, Y. Wu, Z. Zhao, S. De Saeger, and Z. Han. 2015. Multi-walled carbon nanotubes as solid-phase extraction sorbents for simultaneous determination of type A trichothecenes in maize, wheat and rice by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 1423:177–82. doi: 10.1016/j.chroma.2015.10.068.
   PubMed Web of Science ®Google Scholar
• Eom, T., H.-D. Cho, J. Kim, M. Park, J. An, M. Kim, S.-H. Kim, and S. B. Han. 2017. Multiclass mycotoxin analysis in edible oils using a simple solvent extraction method and liquid chromatography with tandem mass spectrometry. Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure & Risk Assessment 34 (11):2011–22. doi: 10.1080/19440049.2017.1363416.
   PubMed Web of Science ®Google Scholar
• Fabregat-Cabello, N., P. Zomer, J. V. Sancho, A. F. Roig-Navarro, and H. G. J. Mol. 2016. Comparison of approaches to deal with matrix effects in LC-MS/MS based determinations of mycotoxins in food and feed. World Mycotoxin Journal 9 (2):149–61. doi: 10.3920/WMJ2014.1872.
   Web of Science ®Google Scholar
• Flores-Flores, M. E., and E. González-Peñas. 2017. An LC–MS/MS method for multi-mycotoxin quantification in cow milk. Food Chemistry 218:378–85. doi: 10.1016/j.foodchem.2016.09.101.
   PubMed Web of Science ®Google Scholar
• García-Moraleja, A., G. Font, J. Mañes, and E. Ferrer. 2015. Analysis of mycotoxins in coffee and risk assessment in Spanish adolescents and adults. Food and Chemical Toxicology 86:225–33. doi: 10.1016/j.fct.2015.10.014.
   PubMed Web of Science ®Google Scholar
• Gbashi, S., P. B. Njobeh, S. De Saeger, M. De Boevre, and N. E. Madala. 2020. Development, chemometric-assisted optimization and in-house validation of a modified pressurized hot water extraction methodology for multi-mycotoxins in maize. Food Chemistry 307:125526. doi: 10.1016/j.foodchem.2019.125526.
   PubMed Web of Science ®Google Scholar
• Herzallah, S. M. 2009. Determination of aflatoxins in eggs, milk, meat and meat products using HPLC fluorescent and UV detectors. Food Chemistry (3)114:1141–6. doi: 10.1016/j.foodchem.2008.10.077.
   Web of Science ®Google Scholar
• Hesseltine. 1976. Conditions leading to mycotoxin contamination of foods and feeds. In Mycotoxins and Other Fungal Related Food Problems, ed. J. Rodricks. Washington, DC: Advances in Chemistry; American Chemical Society.
   Google Scholar
• Hidalgo-Ruiz, J. L., R. Romero-González, J. L. Martínez Vidal, and A. Garrido Frenich. 2019a. A rapid method for the determination of mycotoxins in edible vegetable oils by ultra-high performance liquid chromatography-tandem mass spectrometry. Food Chemistry 288:22–8. doi: 10.1016/j.foodchem.2019.03.003.
   PubMed Web of Science ®Google Scholar
• Hidalgo-Ruiz, J. L., R. Romero-González, J. L. Martínez Vidal, and A. Garrido Frenich. 2019b. Determination of mycotoxins in nuts by ultra high-performance liquid chromatography-tandem mass spectrometry: Looking for a representative matrix. Journal of Food Composition and Analysis 82:103228. doi: 10.1016/j.jfca.2019.05.011.
   Web of Science ®Google Scholar
• Huertas-Pérez, J. F., N. Arroyo-Manzanares, D. Hitzler, F. G. Castro-Guerrero, L. Gámiz-Gracia, and A. M. García-Campaña. 2018. Simple determination of aflatoxins in rice by ultra-high performance liquid chromatography coupled to chemical post-column derivatization and fluorescence detection. Food Chemistry 245:189–95. doi: 10.1016/j.foodchem.2017.10.041.
   PubMed Web of Science ®Google Scholar
• Ibáñez-Vea, M., E. Lizarraga, and E. González-Peñas. 2011. Simultaneous determination of type-A and type-B trichothecenes in barley samples by GC-MS. Food Control 22 (8):1428–34. doi: 10.1016/j.foodcont.2011.03.004.
   Web of Science ®Google Scholar
• Jia, W., X. Chu, Y. Ling, J. Huang, and J. Chang. 2014. Multi-mycotoxin analysis in dairy products by liquid chromatography coupled to quadrupole orbitrap mass spectrometry. Journal of Chromatography A 1345:107–14. doi: 10.1016/j.chroma.2014.04.021.
   PubMed Web of Science ®Google Scholar
• Jiménez, M., J. J. Mateo, and R. Mateo. 2000. Determination of type A trichothecenes by high-performance liquid chromatography with coumarin-3-carbonyl chloride derivatisation and fluorescence detection. Journal of Chromatography A 870 (1–2):473–81. doi: 10.1016/S0021-9673(99)00890-0.
   PubMed Web of Science ®Google Scholar
• Juan, C., J. Mañes, G. Font, and A. Juan-García. 2017. Determination of mycotoxins in fruit berry by-products using QuEChERS extraction method. LWT 86:344–51. doi: 10.1016/j.lwt.2017.08.020.
   Web of Science ®Google Scholar
• Juan, C., A. Zinedine, J. C. Moltó, L. Idrissi, and J. Mañes. 2008. Aflatoxins levels in dried fruits and nuts from Rabat-Salé area. Food Control 19 (9):849–53. doi: 10.1016/j.foodcont.2007.08.010.
   Web of Science ®Google Scholar
• Khuri, A. I., and S. Mukhopadhyay. 2010. Response surface methodology. Wiley Interdisciplinary Reviews: Computational Statistics 2 (2):128–49. doi: 10.1002/wics.73.
   Google Scholar
• Koesukwiwat, U., K. Sanguankaew, and N. Leepipatpiboon. 2014. Evaluation of a modified QuEChERS method for analysis of mycotoxins in rice. Food Chemistry 153:44–51. doi: 10.1016/j.foodchem.2013.12.029.
   PubMed Web of Science ®Google Scholar
• Kokkonen, M., M. Jestoi, and A. Rizzo. 2005. Determination of selected mycotoxins in mould cheeses with liquid chromatography coupled to tandem with mass spectrometry. Food Additives and Contaminants 22 (5):449–56. doi: 10.1080/02652030500089861.
   PubMed Web of Science ®Google Scholar
• Kong, W., R. Wei, A. F. Logrieco, J. Wei, J. Wen, X. Xiao, and M. Yang. 2014. Occurrence of toxigenic fungi and determination of mycotoxins by HPLC-FLD in functional foods and spices in China markets. Food Chemistry 146:320–6. doi: 10.1016/j.foodchem.2013.09.005.
   PubMed Web of Science ®Google Scholar
• Kotal, F., K. Holadová, J. Hajšlová, J. Poustka, and Z. Radová. 1999. Determination of trichothecenes in cereals. Journal of Chromatography. A 830 (1):219–25. doi: 10.1016/S0021-9673(98)00720-1.
   PubMed Web of Science ®Google Scholar
• Lacina, O., M. Zachariasova, J. Urbanova, M. Vaclavikova, T. Cajka, and J. Hajslova. 2012. Critical assessment of extraction methods for the simultaneous determination of pesticide residues and mycotoxins in fruits, cereals, spices and oil seeds employing ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 1262:8–18. doi: 10.1016/j.chroma.2012.08.097.
   PubMed Web of Science ®Google Scholar
• Lattanzio, V. M. T., S. Gatta, M. Della Suman, and A. Visconti. 2011. Development and in-house validation of a robust and sensitive solid-phase extraction liquid chromatography/tandem mass spectrometry method for the quantitative determination of aflatoxins B1, B2, G1, G2, ochratoxin A, deoxynivalenol, zearalenone, T-2 and HT-2 toxins in cereal-based foods Rapid Communications Mass Spectrometry (13)25:1869–80. doi: 10.1002/rcm.5047.
   PubMed Web of Science ®Google Scholar
• Lattanzio, V. M. T., M. Solfrizzo, S. Powers, and A. Visconti. 2007. Simultaneous determination of aflatoxins, ochratoxin A and Fusarium toxins in maize by liquid chromatography/tandem mass spectrometry after multitoxin immunoaffinity cleanup. Rapid Communications Mass Spectrometry (20)21:3253–61. doi: 10.1002/rcm.
   PubMed Web of Science ®Google Scholar
• Leardi, R. 2009. Experimental design in chemistry: A tutorial. Analytica Chimica Acta 652 (1–2):161–72. doi: 10.1016/j.aca.2009.06.015.
   PubMed Web of Science ®Google Scholar
• Li, X., Liu, B. Wang, F. Ma, X. Li, Z. Guo, D. Wang, Y. Wan, F. Deng, L., and S. Zhang. 2018. Determination of 16 mycotoxins in maize by ultrahigh-performance liquid chromatography–tandem mass spectrometry. Analytical Letters 51 (5):702–16. doi: 10.1080/00032719.2017.1344246.
   Web of Science ®Google Scholar
• Liao, C.-D., J. W. Wong, K. Zhang, P. Yang, J. B. Wittenberg, M. W. Trucksess, D. G. Hayward, N. S. Lee, and J. S. Chang. 2015. Multi-mycotoxin analysis of finished grain and nut products using ultrahigh-performance liquid chromatography and positive electrospray ionization-quadrupole orbital ion trap high-resolution mass spectrometry. Journal of Agricultural and Food Chemistry 63 (37):8314–32. doi: 10.1021/jf505049a.
   PubMed Web of Science ®Google Scholar
• Meerpoel, C., A. Vidal, J. D. di Mavungu, B. Huybrechts, E. K. Tangni, M. Devreese, S. Croubels, and S. De Saeger. 2018. Development and validation of an LC–MS/MS method for the simultaneous determination of citrinin and ochratoxin a in a variety of feed and foodstuffs. Journal of Chromatography A 1580:100–9. doi: 10.1016/j.chroma.2018.10.039.
   PubMed Web of Science ®Google Scholar
• Ndube, N., L. van der Westhuizen, I. R. Green, and G. S. Shephard. 2011. HPLC determination of fumonisin mycotoxins in maize: A comparative study of naphthalene-2,3-dicarboxaldehyde and o-phthaldialdehyde derivatization reagents for fluorescence and diode array detection. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Science 879 (23):2239–43. doi: 10.1016/j.jchromb.2011.06.007.
   PubMed Web of Science ®Google Scholar
• Nielsen, K. F., A. F. Ngemela, L. B. Jensen, L. S. De Medeiros, and P. H. Rasmussen. 2015. UHPLC-MS/MS determination of ochratoxin a and fumonisins in coffee using QuEChERS extraction combined with mixed-mode SPE purification. Journal of Agricultural and Food Chemistry 63 (3):1029–34. doi: 10.1021/jf504254q.
   PubMed Web of Science ®Google Scholar
• Nonaka, Y., K. Saito, N. Hanioka, S. Narimatsu, and H. Kataoka. 2009. Determination of aflatoxins in food samples by automated on-line in-tube solid-phase microextraction coupled with liquid chromatography-mass spectrometry. Journal of Chromatography A (20)1216:4416–22. doi: 10.1016/j.chroma.2009.03.035.
   PubMed Web of Science ®Google Scholar
• Ellis, W. O., J. P. Smith, B. K. Simpson, and J. H. Oldham. 1991. Aflatoxins in food: Occurrence, biosynthesis, effects on organisms, detection, and methods of control. Critical Reviews in Food Science and Nutrition 30 (4):403–39. doi: 10.1080/10408399109527551.
   PubMed Web of Science ®Google Scholar
• Ouakhssase, A., A. Chahid, H. Choubbane, A. Aitmazirt, and E. A. Addi. 2019. Optimization and validation of a liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the determination of aflatoxins in maize. Heliyon 5 (5):e01565. doi: 10.1016/j.heliyon.2019.e01565.
   PubMed Web of Science ®Google Scholar
• Oueslati, S., H. Berrada, J. Mañes, and C. Juan. 2018. Presence of mycotoxins in Tunisian infant foods samples and subsequent risk assessment. Food Control 84:362–9. doi: 10.1016/j.foodcont.2017.08.021.
   Web of Science ®Google Scholar
• Park, J., D. H. Kim, J. Y. Moon, J. A. An, Y. W. Kim, S. H. Chung, and C. Lee. 2018. Distribution analysis of twelve mycotoxins in corn and corn-derived products by LC-MS/MS to evaluate the carry-over ratio during wet-milling. Toxins 10 (8):319–5. doi: 10.3390/toxins10080319.
   PubMed Web of Science ®Google Scholar
• Paschoal, F. N., S. Daniele de Azevedo Silva, S. Rafael von Sperling, M. S. de Oliveira, S. V. C. Pereira, and D. S. Scheilla Vitorino Carvalho. 2016. A rapid single-extraction method for the simultaneous determination of aflatoxins B1, B2, G1, G2, fumonisin B1 and zearalenone in corn meal by ultra performance liquid chromatography tandem mass spectrometry. Food Analytical Methods 10:1631–44. 10.1007/s12161-016-0712-2.
   Google Scholar
• Pereira, V. L., J. O. Fernandes, and S. C. Cunha. 2015. Comparative assessment of three cleanup procedures after QuEChERS extraction for determination of trichothecenes (type A and type B) in processed cereal-based baby foods by GC-MS. Food Chemistry 182:143–9. doi: 10.1016/j.foodchem.2015.01.047.
   PubMed Web of Science ®Google Scholar
• Poapolathep, S., P. Tanhan, O. Piasai, K. Imsilp, J. Hajslova, M. Giorgi, S. Kumagai, and A. Poapolathep. 2017. Occurrence and health risk of patulin and pyrethroids in fruit juices consumed in Bangkok, Thailand. Journal of Food Protection 80 (9):1415–21. doi: 10.4315/0362-028X.JFP-17-026.
   PubMed Web of Science ®Google Scholar
• Prelle, A., D. Spadaro, A. Garibaldi, and M. L. Gullino. 2013. A new method for detection of five alternaria toxins in food matrices based on LC-APCI-MS. Food Chemistry (1–2)140:161–7. doi: 10.1016/j.foodchem.2012.12.065.
   PubMed Web of Science ®Google Scholar
• Puntscher, H., M.-L. Kütt, P. Skrinjar, H. Mikula, J. Podlech, J. Fröhlich, D. Marko, and B. Warth. 2018. Tracking emerging mycotoxins in food: Development of an LC-MS/MS method for free and modified Alternaria toxins. Analytical and Bioanalytical Chemistry 410 (18):4481–94. doi: 10.1007/s00216-018-1105-8.
   PubMed Web of Science ®Google Scholar
• Qu, L.-L., Q. Jia, C. Liu, W. Wang, L. Duan, G. Yang, C.-Q. Han, and H. Li. 2018. Thin layer chromatography combined with surface-enhanced Raman spectroscopy for rapid sensing aflatoxins. Journal of Chromatography A 1579:115–20. doi: 10.1016/j.chroma.2018.10.024.
   PubMed Web of Science ®Google Scholar
• Razzazi-Fazeli, E., J. Böhm, and W. Luf. 1999. Determination of nivalenol and deoxynivalenol in wheat using liquid chromatography-mass spectrometry with negative ion atmospheric pressure chemical ionisation. Journal of Chromatography. A (1–2)854:45–55. doi: 10.1016/S0021-9673(99)00616-0.
   PubMed Web of Science ®Google Scholar
• Rubert, J., Z. Dzuman, M. Vaclavikova, M. Zachariasova, C. Soler, and J. Hajslova. 2012. Analysis of mycotoxins in barley using ultra high liquid chromatography high resolution mass spectrometry: Comparison of efficiency and efficacy of different extraction procedures. Talanta 99:712–19. doi: 10.1016/j.talanta.2012.07.010.
   PubMed Web of Science ®Google Scholar
• Saito, K., Ikeuchi, R. and H. Kataoka. 2012. Determination of ochratoxins in nuts and grain samples by in-tube solid-phase microextraction coupled with liquid chromatography-mass spectrometry. J Chromatogr A 1220:1–6. doi: 10.1016/j.chroma.2011.11.008.
   PubMed Web of Science ®Google Scholar
• Sangare-Tigori, B., S. Moukha, H. J. Kouadio, A. M. Betbeder, D. S. Dano, and E. E. Creppy. 2006. Co-occurrence of aflatoxin B1, fumonisin B1, ochratoxin A and zearalenone in cereals and peanuts from Côte d'Ivoire. Food Additives Contamination 23 (10):1000–7. doi: 10.1080/02652030500415686.
   PubMed Web of Science ®Google Scholar
• Scarpino, V., A. Reyneri, and M. Blandino. 2019. Development and comparison of two multiresidue methods for the determination of 17 Aspergillus and Fusarium mycotoxins in cereals using HPLC-ESI-TQ-MS/MS. Front Microbiology 10:361. doi: 10.3389/fmicb.2019.00361.
   PubMed Web of Science ®Google Scholar
• Schollenberger, M., U. Lauber, H. T. Jara, S. Suchy, W. Drochner, and H. M. Müller. 1998. Determination of eight trichothecenes by gas chromatography-mass spectrometry after sample clean-up by a two-stage solid-phase extraction. Journal of hromatography A (1)815:123–32. doi: 10.1016/S0021-9673(98)00454-3.
   PubMed Web of Science ®Google Scholar
• Sharmili, K., S. Jinap, and R. Sukor. 2016. Development, optimization and validation of QuEChERS based liquid chromatography tandem mass spectrometry method for determination of multimycotoxin in vegetable oil. Food Control 70:152–60. doi: 10.1016/j.foodcont.2016.04.035.
   Web of Science ®Google Scholar
• Silva, L., M. Fernández-Franzón, G. Font, A. Pena, I. Silveira, C. Lino, and J. Mañes. 2009. Analysis of fumonisins in corn-based food by liquid chromatography with fluorescence and mass spectrometry detectors. Food Chemistry 112 (4):1031–7. doi: 10.1016/j.foodchem.2008.06.080.
   Web of Science ®Google Scholar
• Sirhan, A. Y., G. H. Tan, and R. C. S. Wong. 2013. Determination of aflatoxins in food using liquid chromatography coupled with electrospray ionization quadrupole time of flight mass spectrometry (LC-ESI-QTOF-MS/MS). Food Control (1)31:35–44. doi: 10.1016/j.foodcont.2012.09.016.
   Web of Science ®Google Scholar
• Solfrizzo, M., L. Gambacorta, R. Bibi, M. Ciriaci, A. Paoloni, and I. Pecorelli. 2018. Multimycotoxin analysis by LC-MS/MS in cereal food and feed: Comparison of different approaches for extraction, purification, and calibration. Journal of AOAC International 101 (3):647–57. doi: 10.5740/jaoacint.17-0339.
   PubMed Web of Science ®Google Scholar
• Sørensen, L. K. and T. H. Elbaek. 2005. Determination of mycotoxins in bovine milk by liquid chromatography tandem mass spectrometry. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Science 820 (2):183–96. doi: 10.1016/j.jchromb.2005.03.020.
   PubMed Web of Science ®Google Scholar
• Spanjer, M. C., P. M. Rensen, and J. M. Scholten. 2008. LC-MS/MS multi-method for mycotoxins after single extraction, with validation data for peanut, pistachio, wheat, maize, cornflakes, raisins and figs. Food Additives and Contaminants. Part A, Chemistry, Analysis, Control, Exposure and Risk Assessment 25 (4):472–89. doi: 10.1080/02652030701552964.
   Google Scholar
• Stoev, S. D. 2013. Food safety and increasing hazard of mycotoxin occurrence in foods and feeds. Critical Reviews in Food Science and Nutrition 53 (9):887–901. doi: 10.1080/10408398.2011.571800.
   PubMed Web of Science ®Google Scholar
• Sulyok, M., F. Berthiller, R. Krska, and R. Schuhmacher. 2006. Development and validation of a liquid chromatography/tandem mass spectrometric method for the determination of 39 mycotoxins in wheat and maize. Rapid Communications in Mass Spectrometry (18)20:2649–59. doi: 10.1002/rcm.
   PubMed Web of Science ®Google Scholar
• Sun, D., Qiu, N. Zhou, S. Lyu, B. Zhang, S. Li, J. Zhao, Y. and Y. Wu. 2019. Development of sensitive and reliable UPLC-MS/MS methods for food analysis of emerging mycotoxins in China Total Diet Study. Toxins (3)11:166. doi: 10.3390/toxins11030166.
   Web of Science ®Google Scholar
• Takino, M., T. Tanaka, K. Yamaguchi, and T. Nakahara. 2004. Atmospheric pressure photo-ionization liquid chromatography/mass spectrometric determination of aflatoxins in food. Food Additives Contamination 21 (1):76–84. doi: 10.1080/02652030310001632538.
   PubMed Web of Science ®Google Scholar
• Tanaka, H., M. Takino, Y. Sugita-Konishi, and T. Tanaka. 2006. Development of a liquid chromatography/time-of-flight mass spectrometric method for the simultaneous determination of trichothecenes, zearalenone and aflatoxins in foodstuffs. Rapid Communications Mass Spectrometry (9)20:1422–8. doi: 10.1002/rcm.
   PubMed Web of Science ®Google Scholar
• Tanaka, T., A. Yoneda, S. Inoue, Y. Sugiura, and Y. Ueno. 2000. Simultaneous determination of trichothecene mycotoxins and zearalenone in cereals by gas chromatography-mass spectrometry. Journal of Chromatography A (1–2)882:23–8. doi: 10.1016/S0021-9673(00)00063-7.
   PubMed Web of Science ®Google Scholar
• Tittlemier, S. A., B. Cramer, C. Dall’Asta, M. H. Iha, V. M. T. Lattanzio, C. Maragos, M. Solfrizzo, M. Stranska, J. Stroka, and M. Sumarah. 2020. Developments in mycotoxin analysis: An update for 2018-19. World Mycotoxin Journal 13 (1):3–24. doi: 10.3920/WMJ2019.2535.
   Web of Science ®Google Scholar
• Tsiplakou, E., C. Anagnostopoulos, K. Liapis, S. A. Haroutounian, and G. Zervas. 2014. Determination of mycotoxins in feedstuffs and ruminant's milk using an easy and simple LC-MS/MS multiresidue method. Talanta 130:8–19. doi: 10.1016/j.talanta.2014.06.018.
   PubMed Web of Science ®Google Scholar
• Vaclavikova, M., Z. Dzuman, O. Lacina, M. Fenclova, Z. Veprikova, M. Zachariasova, and J. Hajslova. 2015. Monitoring survey of patulin in a variety of fruit-based products using a sensitive UHPLC-MS/MS analytical procedure. Food Control 47:577–84. doi: 10.1016/j.foodcont.2014.07.064.
   Web of Science ®Google Scholar
• Valle-Algarra, F. M., A. Medina, J. V. Gimeno-Adelantado, A. Llorens, M. Jiménez, and R. Mateo. 2005. Comparative assessment of solid-phase extraction clean-up procedures, GC columns and perfluoroacylation reagents for determination of type B trichothecenes in wheat by GC-ECD. Talanta 66 (1):194–201. doi: 10.1016/j.talanta.2004.11.007.
   PubMed Web of Science ®Google Scholar
• Van de Perre, E., N. Deschuyffeleer, L. Jacxsens, F. Vekeman, W. Van Der Hauwaert, S. Asam, M. Rychlik, F. Devlieghere, and B. De Meulenaer. 2014. Screening of moulds and mycotoxins in tomatoes, bell peppers, onions, soft red fruits and derived tomato products. Food Control 37 (1):165–70. doi: 10.1016/j.foodcont.2013.09.034.
   Google Scholar
• Vidal, A., S. Ouhibi, R. Ghali, A. Hedhili, S. De Saeger, and M. De Boevre. 2019. The mycotoxin patulin: An updated short review on occurrence, toxicity and analytical challenges. Food and Chemical Toxicology 129:249–56. doi: 10.1016/j.fct.2019.04.048.
   PubMed Web of Science ®Google Scholar
• Walravens, J., Mikula, H. Rychlik, M. Asam, S. Devos, T. Njumbe Ediage, E. Diana Di Mavungu, J. Jacxsens, L. Van Landschoot, A. Vanhaecke, L., et al. 2016. Validated UPLC-MS/MS methods to quantitate free and conjugated alternaria toxins in commercially available tomato products and fruit and vegetable juices in Belgium. Journal of Agricultural and Food Chemistry 64 (24):5101–9. doi: 10.1021/acs.jafc.6b01029.
   PubMed Web of Science ®Google Scholar
• Welke, J. E., M. Hoeltz, H. A. Dottori, and I. B. Noll. 2009. Quantitative analysis of patulin in apple juice by thin-layer chromatography using a charge coupled device detector. Food Additives Contamination Part A Chemistry, Analysis, Control, Exposure and Risk Assessment (5)26:754–8. doi: 10.1080/02652030802662746.
   Web of Science ®Google Scholar
• Wu, F. 2007. Measuring the economic impacts of Fusarium toxins in animal feeds. Animal Feed Science and Technology 137 (3–4):363–74. doi: 10.1016/j.anifeedsci.2007.06.010.
   Web of Science ®Google Scholar
• Yogendrarajah, P., C. Van Poucke, B. De Meulenaer, and S. De Saeger. 2013. Development and validation of a QuEChERS based liquid chromatography tandem mass spectrometry method for the determination of multiple mycotoxins in spices. Journal of Chromatography A 1297:1–11. doi: 10.1016/j.chroma.2013.04.075.
   PubMed Web of Science ®Google Scholar
• Zhao, H., X. Chen, C. Shen, and B. Qu. 2017. Determination of 16 mycotoxins in vegetable oils using a QuEChERS method combined with high-performance liquid chromatography-tandem mass spectrometry. Food Additives Contamination Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 34 (2):255–64. doi: 10.1080/19440049.2016.1266096.
   PubMed Web of Science ®Google Scholar
• Zhao, Y., J. Huang, L. Ma, and F. Wang. 2017. Development and validation of a simple and fast method for simultaneous determination of aflatoxin B1 and sterigmatocystin in grains. Food Chemistry 221:11–17. doi: 10.1016/j.foodchem.2016.10.036.
   PubMed Web of Science ®Google Scholar
• Zhao, Z., Yang, X. Zhao,X. Bai, B. Yao, C. Liu, N. Wang, J., and Zhou, C. 2017. Vortex-assisted dispersive liquid-liquid microextraction for the analysis of major Aspergillus and Penicillium mycotoxins in rice wine by liquid chromatography-tandem mass spectrometry. Food Control 73:862–8. doi: 10.1016/j.foodcont.2016.09.035.
   Web of Science ®Google Scholar
• Zhao, Z., X. Yang, X. Zhao, L. Chen, B. Bai, C. Zhou, and J. Wang. 2018. Method development and validation for the analysis of emerging and traditional fusarium mycotoxins in pepper, potato, tomato, and cucumber by UPLC-MS/MS. Food Analytical Methods 11 (6):1780–8. doi: 10.1007/s12161-018-1180-7.
   Web of Science ®Google Scholar
• Zhou, J., J. J. Xu, J. M. Cong, Z. X. Cai, J. S. Zhang, J. L. Wang, and Y. P. Ren. 2018. Optimization for quick, easy, cheap, effective, rugged and safe extraction of mycotoxins and veterinary drugs by response surface methodology for application to egg and milk. Journal of Chromatography A 1532:20–9. doi: 10.1016/j.chroma.2017.11.050.
   PubMed Web of Science ®Google Scholar
• Zhou, N.-Z., P. Liu, X.-C. Su, Y.-H. Liao, N.-S. Lei, Y.-H. Liang, S.-H. Zhou, W.-S. Lin, J. Chen, Y.-Q. Feng, et al. 2017. Low-cost humic acid-bonded silica as an effective solid-phase extraction sorbent for convenient determination of aflatoxins in edible oils. Analytica Chimica Acta 970:38–46. doi: 10.1016/j.aca.2017.02.029.
   PubMed Web of Science ®Google Scholar