Citrus flavonoids and their antioxidant evaluation

References

• Abdel-Raheem, I. T., and A. A. Abdel-Ghany. 2009. Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats. Journal of the Egyptian National Cancer Institute 21 (2):175–84.
   PubMedGoogle Scholar
• Abolaji, A. O., O. V. Babalola, A. K. Adegoke, and E. O. Farombi. 2017. Hesperidin, a citrus bioflavonoid, alleviates trichloroethylene-induced oxidative stress in Drosophila melanogaster. Environmental Toxicology and Pharmacology 55:202–7. doi: 10.1016/j.etap.2017.08.038.
   PubMed Web of Science ®Google Scholar
• Agir, M. S., and G. Eraslan. 2019. The effect of diosmin against liver damage caused by cadmium in rats. Journal of Food Biochemistry 43:e12966.
   PubMed Web of Science ®Google Scholar
• Ali, M. Y., S. Zaib, M. M. Rahman, S. Jannat, J. Iqbal, S. K. Park, and M. S. Chang. 2019. Didymin, a dietary citrus flavonoid exhibits anti-diabetic complications and promotes glucose uptake through the activation of PI3K/Akt signaling pathway in insulin-resistant HepG2 cells. Chemico-Biological Interactions 305:180–94. doi: 10.1016/j.cbi.2019.03.018.
   PubMed Web of Science ®Google Scholar
• Allawadhi, P., A. Khurana, N. Sayed, P. Kumari, and C. Godugu. 2018. Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention . Phytotherapy Research : PTR 32 (10):1908–32. doi: 10.1002/ptr.6152.
   PubMed Web of Science ®Google Scholar
• Al-Yahya, M. A., R. A. Mothana, M. S. Al-Said, K. E. El-Tahir, M. Al-Sohaibani, and S. Rafatullah. 2013. Citrus medica "Otroj": Attenuates oxidative stress and cardiac dysrhythmia in isoproterenol-induced cardiomyopathy in rats. Nutrients 5 (11):4269–83. doi: 10.3390/nu5114269.
   PubMed Web of Science ®Google Scholar
• Anandan, R., and P. Subramanian. 2012. Renal protective effect of hesperidin on gentamicin-induced acute nephrotoxicity in male Wistar albino rats. Redox Report : Communications in Free Radical Research 17 (5):219–26. doi: 10.1179/1351000212Y.0000000019.
   PubMed Web of Science ®Google Scholar
• Arab, H. H., S. A. Salama, H. A. Omar, E. S. A. Arafa, and I. A. Maghrabi. 2015. Diosmin protects against ethanol-induced gastric injury in rats: Novel anti-ulcer actions. PLoS One 10 (3):e0122417. doi: 10.1371/journal.pone.0122417.
   PubMed Web of Science ®Google Scholar
• Arafa, H. M., H. A. Aly, M. F. Abd-Ellah, and H. M. El-Refaey. 2009. Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance. Toxicology and Industrial Health 25 (6):417–27. doi: 10.1177/0748233709106624.
   PubMed Web of Science ®Google Scholar
• Assefa, A. D., E. Y. Ko, S. H. Moon, and Y. S. Keum. 2016. Antioxidant and antiplatelet activities of flavonoid-rich fractions of three citrus fruits from Korea. 3 Biotech 6 (1):109. doi: 10.1007/s13205-016-0424-8.
   PubMedGoogle Scholar
• Austin, M. B., and A. J. P. Noel. 2003. The chalcone synthase superfamily of type III polyketide synthases. Natural Product Reports 20 (1):79–110. doi: 10.1039/b100917f.
   PubMed Web of Science ®Google Scholar
• Barreca, D., E. Bellocco, C. Caristi, U. Leuzzi, and G. Gattuso. 2010. Flavonoid Composition and Antioxidant Activity of Juices from Chinotto ( Citrus x myrtifolia Raf.) fruits at different ripening stages. Journal of Agricultural and Food Chemistry 58 (5):3031–6. doi: 10.1021/jf9044809.
   PubMed Web of Science ®Google Scholar
• Barreca, D., E. Bellocco, C. Caristi, U. Leuzzi, and G. Gattuso. 2011. Flavonoid profile and radical-scavenging activity of Mediterranean sweet lemon (Citrus limetta Risso) juice. Food Chemistry 129 (2):417–22. doi: 10.1016/j.foodchem.2011.04.093.
   PubMed Web of Science ®Google Scholar
• Bastien, M., P. Poirier, I. Lemieux, and J.-P. Després. 2014. Overview of epidemiology and contribution of obesity to cardiovascular disease. Progress in Cardiovascular Diseases 56 (4):369–81. doi: 10.1016/j.pcad.2013.10.016.
   PubMed Web of Science ®Google Scholar
• Bayomy, N. A., S. H. Elshafhey, R. H. ElBakary, and E. Z. Abdelaziz. 2014. Protective effect of hesperidin against lung injury induced by intestinal ischemia/reperfusion in adult albino rats: Histological, immunohistochemical and biochemical study. Tissue & Cell 46 (5):304–10. doi: 10.1016/j.tice.2014.05.009.
   PubMed Web of Science ®Google Scholar
• Bentli, R., O. Ciftci, A. Cetin, M. Unlu, N. Basak, and M. Cay. 2013. Oral administration of hesperidin, a citrus flavonone, in rats counteracts the oxidative stress, the inflammatory cytokine production, and the hepatotoxicity induced by the ingestion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). European Cytokine Network 24 (2):91–6. doi: 10.1684/ecn.2013.0337.
   PubMed Web of Science ®Google Scholar
• Berim, A., and D. R. Gang. 2016. Methoxylated flavones: Occurrence, importance, biosynthesis. Phytochemistry Reviews 15 (3):363–90. doi: 10.1007/s11101-015-9426-0.
   Web of Science ®Google Scholar
• Bhargava, P., V. K. Verma, S. Malik, S. I. Khan, J. Bhatia, and D. S. Arya. 2019. Hesperidin regresses cardiac hypertrophy by virtue of PPAR-γ agonistic, anti-inflammatory, antiapoptotic, and antioxidant properties. Journal of Biochemical and Molecular Toxicology 33 (5):e22283. doi: 10.1002/jbt.22283.
   PubMed Web of Science ®Google Scholar
• Bhojwani, D., and C.-H. Pui. 2013. Relapsed childhood acute lymphoblastic leukaemia. The Lancet Oncology 14 (6):e205–e217. doi: 10.1016/S1470-2045(12)70580-6.
   PubMed Web of Science ®Google Scholar
• Bodduluru, L. N., E. R. Kasala, R. M. Madhana, C. C. Barua, M. I. Hussain, P. Haloi, and P. Borah. 2016. Naringenin ameliorates inflammation and cell proliferation in benzo(a)pyrene induced pulmonary carcinogenesis by modulating CYP1A1, NFκB and PCNA expression. International Immunopharmacology 30:102–10. doi: 10.1016/j.intimp.2015.11.036.
   PubMed Web of Science ®Google Scholar
• Bussmann, A. J. C., S. M. Borghi, T. H. Zaninelli, T. S. Dos Santos, C. F. S. Guazelli, V. Fattori, T. P. Domiciano, F. A. Pinho-Ribeiro, K. W. Ruiz-Miyazawa, A. M. B. Casella, et al. 2019. The citrus flavanone naringenin attenuates zymosan-induced mouse joint inflammation: Induction of Nrf2 expression in recruited CD45(+) hematopoietic cells. Inflammopharmacology 27 (6):1229–42., Jr. doi: 10.1007/s10787-018-00561-6.
   PubMed Web of Science ®Google Scholar
• Butryee, C., P. Sungpuag, and C. Chitchumroonchokchai. 2009. Effect of processing on the flavonoid content and antioxidant capacity of Citrus hystrix leaf. International Journal of Food Sciences and Nutrition 60 (sup2):162–74. doi: 10.1080/09637480903018816.
   PubMed Web of Science ®Google Scholar
• Carino-Cortes, R., I. Alvarez-Gonzalez, L. Martino-Roaro, and E. Madrigal-Bujaidar. 2010. Effect of naringin on the DNA damage induced by daunorubicin in mouse hepatocytes and cardiocytes. Biological & Pharmaceutical Bulletin 33 (4):697–701. doi: 10.1248/bpb.33.697.
   PubMed Web of Science ®Google Scholar
• Cases, J., C. Romain, C. Dallas, A. Gerbi, and J. M. Rouanet. 2015. A 12-week randomized double-blind parallel pilot trial of Sinetrol XPur on body weight, abdominal fat, waist circumference, and muscle metabolism in overweight men. International Journal of Food Sciences and Nutrition 66 (4):471–7. doi: 10.3109/09637486.2015.1042847.
   PubMed Web of Science ®Google Scholar
• Castro-Vazquez, L., Alanon, M. E., Rodriguez-Robledo, V., Perez-Coello, M. S., Hermosin-Gutierrez, I., Diaz-Maroto, M. C., Jordan, J., Galindo, M. F. and Arroyo-Jimenez Mdel, M. (2016). Bioactive flavonoids, antioxidant behaviour, and cytoprotective effects of dried grapefruit peels (Citrus paradisi Macf.). Oxidative Medicine and Cellular Longevity 2016:1–12. doi: 10.1155/2016/8915729.
   Google Scholar
• Chen, J., H. Mo, R. Guo, Q. You, R. Huang, and K. Wu. 2014b. Inhibition of the leptin-induced activation of the p38 MAPK pathway contributes to the protective effects of naringin against high glucose-induced injury in H9c2 cardiac cells. International Journal of Molecular Medicine 33 (3):605–12. doi: 10.3892/ijmm.2014.1614.
   PubMed Web of Science ®Google Scholar
• Chen, J., R. Guo, H. Yan, L. Tian, Q. You, S. Li, R. Huang, and K. Wu. 2014a. Naringin inhibits ROS-activated MAPK pathway in high glucose-induced injuries in H9c2 cardiac cells. Basic & Clinical Pharmacology & Toxicology 114 (4):293–304. doi: 10.1111/bcpt.12153.
   PubMed Web of Science ®Google Scholar
• Chen, X. M., A. R. Tait, and D. D. Kitts. 2017. Flavonoid composition of orange peel and its association with antioxidant and anti-inflammatory activities. Food Chemistry 218:15–21. doi: 10.1016/j.foodchem.2016.09.016.
   PubMed Web of Science ®Google Scholar
• Cho, J. 2006. Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin. Archives of Pharmacal Research 29 (8):699–706. doi: 10.1007/BF02968255.
   PubMed Web of Science ®Google Scholar
• Choi, B. K., T. W. Kim, D. R. Lee, W. H. Jung, J. H. Lim, J. Y. Jung, S. H. Yang, and J. W. Suh. 2015. A polymethoxy flavonoids-rich Citrus aurantium extract ameliorates ethanol-induced liver injury through modulation of AMPK and Nrf2-related signals in a binge drinking mouse model. Phytotherapy Research : PTR 29 (10):1577–84. doi: 10.1002/ptr.5415.
   PubMed Web of Science ®Google Scholar
• Cimino, F., M. Cristani, A. Saija, F. P. Bonina, and F. Virgili. 2007. Protective effects of a red orange extract on UVB-induced damage in human keratinocytes. BioFactors (Oxford, England) 30 (2):129–38. doi: 10.1002/biof.5520300206.
   PubMed Web of Science ®Google Scholar
• Clavo, B., F. Rodríguez-Esparragón, D. Rodríguez-Abreu, G. Martínez-Sánchez, P. Llontop, D. Aguiar-Bujanda, L. Fernández-Pérez, and N. Santana-Rodríguez. 2019. Modulation of oxidative stress by ozone therapy in the prevention and treatment of chemotherapy-induced toxicity: Review and prospects. Antioxidants 8 (12):588. doi: 10.3390/antiox8120588.
   Web of Science ®Google Scholar
• Codoner-Franch, P., A. B. Lopez-Jaen, A. De La Mano-Hernandez, E. Sentandreu, R. Simo-Jorda, and V. Valls-Belles. 2010. Oxidative markers in children with severe obesity following low-calorie diets supplemented with mandarin juice. Acta Paediatrica 99 (12):1841–6. doi: 10.1111/j.1651-2227.2010.01903.x.
   PubMed Web of Science ®Google Scholar
• Constans, J., C. Bennetau-Pelissero, J. F. Martin, E. Rock, A. Mazur, A. Bedel, C. Morand, and A. M. Berard. 2015. Marked antioxidant effect of orange juice intake and its phytomicronutrients in a preliminary randomized cross-over trial on mild hypercholesterolemic men. Clinical Nutrition (Edinburgh, Scotland) 34 (6):1093–100. doi: 10.1016/j.clnu.2014.12.016.
   PubMed Web of Science ®Google Scholar
• Curro, M., R. Risitano, N. Ferlazzo, S. Cirmi, C. Gangemi, D. Caccamo, R. Ientile, and M. Navarra. 2016. Citrus bergamia juice extract attenuates β-amyloid-induced pro-inflammatory activation of THP-1 cells through MAPK and AP-1 pathways. Scientific Reports 6:20809. doi: 10.1038/srep20809.
   PubMed Web of Science ®Google Scholar
• Da Pozzo, E., B. Costa, C. Cavallini, L. Testai, A. Martelli, V. Calderone, and C. Martini. 2017. The citrus flavanone naringenin protects myocardial cells against age-associated damage. Oxidative Medicine and Cellular Longevity 2017:9536148. doi: 10.1155/2017/9536148.
   PubMed Web of Science ®Google Scholar
• Da Pozzo, E., M. De Leo, I. Faraone, L. Milella, C. Cavallini, E. Piragine, L. Testai, V. Calderone, L. Pistelli, A. Braca, et al. 2018. Antioxidant and antisenescence effects of bergamot juice. Oxidative Medicine and Cellular Longevity 2018:9395804. doi: 10.1155/2018/9395804.
   PubMed Web of Science ®Google Scholar
• da Silva, L. M., B. C. Pezzini, L. B. Somensi, L. N. Bolda Mariano, M. Mariott, T. Boeing, A. C. Dos Santos, B. Longo, V. Cechinel-Filho, P. de Souza, et al. 2019. Hesperidin, a citrus flavanone glycoside, accelerates the gastric healing process of acetic acid-induced ulcer in rats. Chemico-Biological Interactions 308:45–50. doi: 10.1016/j.cbi.2019.05.011.
   PubMed Web of Science ®Google Scholar
• Dabelea, D., E. J. Mayer-Davis, S. Saydah, G. Imperatore, B. Linder, J. Divers, R. Bell, A. Badaru, J. W. Talton, T. Crume, et al. 2014. Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. Jama 311 (17):1778–86., doi: 10.1001/jama.2014.3201.
   PubMed Web of Science ®Google Scholar
• De Leo, M., E. Piragine, A. Pirone, A. Braca, L. Pistelli, V. Calderone, V. Miragliotta, and L. Testai. 2020. Protective Effects of Bergamot (Citrus bergamia Risso & Poiteau) Juice in Rats Fed with High-Fat Diet. Planta Medica 86 (3):180–9. doi: 10.1055/a-1070-9325.
   PubMed Web of Science ®Google Scholar
• Degirmenci, H., and H. Erkurt. 2019. Relationship between volatile components, antimicrobial and antioxidant properties of the essential oil, hydrosol and extracts of Citrus aurantium L. flowers. Journal of Infection and Public Health 13 (1):58–67.
   PubMed Web of Science ®Google Scholar
• Doostdar, H., J. P. Shapiro, R. Niedz, M. D. Burke, T. G. Mccollum, R. E. Mcdonald, and R. T. Mayer. 1995. A cytochrome-P450 mediated naringenin 3′-hydroxylase from sweet orange cell-cultures. Plant and Cell Physiology 36:69–77.
   Web of Science ®Google Scholar
• Elavarasan, J., P. Velusamy, T. Ganesan, S. K. Ramakrishnan, D. Rajasekaran, and K. Periandavan. 2012. Hesperidin-mediated expression of Nrf2 and upregulation of antioxidant status in senescent rat heart. The Journal of Pharmacy and Pharmacology 64 (10):1472–82. doi: 10.1111/j.2042-7158.2012.01512.x.
   PubMed Web of Science ®Google Scholar
• Elshazly, S. M., D. M. Abd El Motteleb, and I. Ibrahim. 2018. Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats. Chemico-Biological Interactions 291:153–61. doi: 10.1016/j.cbi.2018.06.027.
   PubMed Web of Science ®Google Scholar
• Eltzschig, H. K., and T. Eckle. 2011. Ischemia and reperfusion-from mechanism to translation. Nature Medicine 17 (11):1391–401. doi: 10.1038/nm.2507.
   PubMed Web of Science ®Google Scholar
• Esmaeili, M. A., and M. Alilou. 2014. Naringenin attenuates CCl4 -induced hepatic inflammation by the activation of an Nrf2-mediated pathway in rats. Clinical and Experimental Pharmacology & Physiology 41 (6):416–22. doi: 10.1111/1440-1681.12230.
   PubMed Web of Science ®Google Scholar
• Ferreira, P. S., L. C. Spolidorio, J. A. Manthey, and T. B. Cesar. 2016. Citrus flavanones prevent systemic inflammation and ameliorate oxidative stress in C57BL/6J mice fed high-fat diet. Food & Function 7 (6):2675–81. doi: 10.1039/c5fo01541c.
   PubMed Web of Science ®Google Scholar
• Fouad, A. A., W. H. Albuali, A. Zahran, and W. Gomaa. 2014. Protective effect of naringenin against gentamicin-induced nephrotoxicity in rats. Environmental Toxicology and Pharmacology 38 (2):420–9. doi: 10.1016/j.etap.2014.07.015.
   PubMed Web of Science ®Google Scholar
• Friedman, G. D., A. Siegelaub, and C. C. Seltzer. 1974. Cigarettes, alcohol, coffee and peptic ulcer. The New England Journal of Medicine 290 (9):469–73. doi: 10.1056/NEJM197402282900901.
   PubMed Web of Science ®Google Scholar
• Gattuso, G., C. Caristi, C. Gargiulli, E. Bellocco, G. Toscano, and U. Leuzzi. 2006. Flavonoid glycosides in bergamot juice (Citrus bergamia risso). Journal of Agricultural and Food Chemistry 54 (11):3929–35. doi: 10.1021/jf060348z.
   PubMed Web of Science ®Google Scholar
• Ge, W. J., K. M. Zhao, X. W. Wang, H. Y. Li, M. Yu, M. M. He, X. T. Xue, Y. F. Zhu, C. Zhang, Y. W. Cheng, et al. 2017. iASPP is an antioxidative factor and drives cancer growth and drug resistance by competing with Nrf2 for Keap1 binding. Cancer Cell 32 (5):561–73.e6. doi: 10.1016/j.ccell.2017.09.008.
   PubMed Web of Science ®Google Scholar
• Ghanim, H., P. Mohanty, R. Pathak, A. Chaudhuri, C. L. Sia, and P. Dandona. 2007. Orange juice or fructose intake does not induce oxidative and inflammatory response. Diabetes Care 30 (6):1406–11. doi: 10.2337/dc06-1458.
   PubMed Web of Science ®Google Scholar
• Ghasemi, K., Y. Ghasemi, and M. A. Ebrahimzadeh. 2009. Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues. Pakistan Journal of Pharmaceutical Sciences 22 (3):277–81.
   PubMed Web of Science ®Google Scholar
• Golechha, M., U. Chaudhry, J. Bhatia, D. Saluja, and D. S. Arya. 2011. Naringin protects against kainic acid-induced status epilepticus in rats: Evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. Biological & Pharmaceutical Bulletin 34 (3):360–5. doi: 10.1248/bpb.34.360.
   PubMed Web of Science ®Google Scholar
• Goncalves, D., C. Lima, P. Ferreira, P. Costa, A. Costa, W. Figueiredo, and T. Cesar. 2017. Orange juice as dietary source of antioxidants for patients with hepatitis C under antiviral therapy. Food & Nutrition Research 61 (1):1296675 doi: 10.1080/16546628.2017.1296675.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Molina, E., D. A. Moreno, and C. Garcia-Viguera. 2008. Genotype and harvest time influence the phytochemical quality of Fino lemon juice (Citrus limon (L.) Burm. F.) for industrial use. Journal of Agricultural and Food Chemistry 56 (5):1669–75. doi: 10.1021/jf073282w.
   PubMed Web of Science ®Google Scholar
• Gopinath, K., and G. Sudhandiran. 2012. Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway. Neuroscience 227:134–43. doi: 10.1016/j.neuroscience.2012.07.060.
   PubMed Web of Science ®Google Scholar
• Guan, S., Q. Tang, W. Liu, R. Zhu, and B. Li. 2014. Nobiletin Inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration and attenuates neointimal hyperplasia in a rat carotid artery injury model. Drug Development Research 75 (8):489–96. doi: 10.1002/ddr.21230.
   PubMed Web of Science ®Google Scholar
• Guo, S., X. Wu, J. Zheng, N. Charoensinphon, P. Dong, P. Qiu, M. Song, Z. Tang, and H. Xiao. 2018. Anti-inflammatory effect of xanthomicrol, a major colonic metabolite of 5-demethyltangeretin. Food & Function 9 (6):3104–13. doi: 10.1039/c8fo00279g.
   PubMed Web of Science ®Google Scholar
• Habauzit, V., M. A. Verny, D. Milenkovic, N. Barber-Chamoux, A. Mazur, C. Dubray, and C. Morand. 2015. Flavanones protect from arterial stiffness in postmenopausal women consuming grapefruit juice for 6 mo: A randomized, controlled, crossover trial. The American Journal of Clinical Nutrition 102 (1):66–74. doi: 10.3945/ajcn.114.104646.
   PubMed Web of Science ®Google Scholar
• Hadi, H. E., R. Vettor, and M. Rossato. 2018. Vitamin E as a treatment for nonalcoholic fatty liver disease: Reality or myth? Antioxidants 7:12.
   Web of Science ®Google Scholar
• He, P., S. Yan, X. Wen, S. Zhang, Z. Liu, X. Liu, and C. Xiao. 2019. Eriodictyol alleviates lipopolysaccharide-triggered oxidative stress and synaptic dysfunctions in BV-2 microglial cells and mouse brain. Journal of Cellular Biochemistry 120 (9):14756–70. doi: 10.1002/jcb.28736.
   PubMed Web of Science ®Google Scholar
• Heo, H. J., D. O. Kim, S. C. Shin, M. J. Kim, B. G. Kim, and D. H. Shin. 2004. Effect of antioxidant flavanone, naringenin, from Citrus junoson neuroprotection. Journal of Agricultural and Food Chemistry 52 (6):1520–5. doi: 10.1021/jf035079g.
   PubMed Web of Science ®Google Scholar
• Heo, S. D., J. Kim, Y. Choi, P. Ekanayake, M. Ahn, and T. Shin. 2020. Hesperidin improves motor disability in rat spinal cord injury through anti-inflammatory and antioxidant mechanism via Nrf-2/HO-1 pathway. Neuroscience Letters 715:134619. doi: 10.1016/j.neulet.2019.134619.
   PubMed Web of Science ®Google Scholar
• Hermenean, A., A. Ardelean, M. Stan, N. Hadaruga, C. V. Mihali, M. Costache, and A. Dinischiotu. 2014. Antioxidant and hepatoprotective effects of naringenin and its β-cyclodextrin formulation in mice intoxicated with carbon tetrachloride: A comparative study . Journal of Medicinal Food 17 (6):670–7. doi: 10.1089/jmf.2013.0007.
   PubMed Web of Science ®Google Scholar
• Holditch, S. J., C. N. Brown, A. M. Lombardi, K. N. Nguyen, and C. L. Edelstein. 2019. Recent advances in models, mechanisms, biomarkers, and interventions in cisplatin-induced acute kidney injury. International Journal of Molecular Sciences 20 (12):3011. doi: 10.3390/ijms20123011.
   PubMed Web of Science ®Google Scholar
• Huang, D., X. Wang, Z. Z. Tang, Y. Yuan, Y. T. Xu, J. X. He, X. L. Jiang, S. A. Peng, L. Li, E. Butelli, et al. 2018. Subfunctionalization of the Ruby2-Ruby1 gene cluster during the domestication of citrus. Nature Plants 4 (11):930–41. +. doi: 10.1038/s41477-018-0287-6.
   PubMed Web of Science ®Google Scholar
• Hwang, S. L., and G. C. Yen. 2008. Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells. Journal of Agricultural and Food Chemistry 56 (3):859–64. doi: 10.1021/jf072826r.
   PubMed Web of Science ®Google Scholar
• Hwang, S. L., and G. C. Yen. 2009. Modulation of Akt, JNK, and p38 activation is involved in citrus flavonoid-mediated cytoprotection of PC12 cells challenged by hydrogen peroxide. Journal of Agricultural and Food Chemistry 57 (6):2576–82. doi: 10.1021/jf8033607.
   PubMed Web of Science ®Google Scholar
• Impellizzeri, D., M. Cordaro, M. Campolo, E. Gugliandolo, E. Esposito, F. Benedetto, S. Cuzzocrea, and M. Navarra. 2016. Anti-inflammatory and Antioxidant Effects of Flavonoid-Rich Fraction of Bergamot Juice (BJe) in a Mouse Model of Intestinal Ischemia/Reperfusion Injury. Frontiers in Pharmacology 7:203.
   PubMed Web of Science ®Google Scholar
• Ishii, T., K. Itoh, S. Takahashi, H. Sato, T. Yanagawa, Y. Katoh, S. Bannai, and M. Yamamoto. 2000. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. The Journal of Biological Chemistry 275 (21):16023–9. doi: 10.1074/jbc.275.21.16023.
   PubMed Web of Science ®Google Scholar
• Islam, J., A. Shree, S. M. Afzal, A. Vafa, and S. Sultana. 2020. Protective effect of Diosmin against benzo(a)pyrene-induced lung injury in Swiss Albino Mice. Environmental Toxicology 35 (7):747–57. doi: 10.1002/tox.22909.
   PubMed Web of Science ®Google Scholar
• Jain, D., M. K. Bansal, R. Dalvi, A. Upganlawar, and R. Somani. 2014. Protective effect of diosmin against diabetic neuropathy in experimental rats. Journal of Integrative Medicine 12 (1):35–41. doi: 10.1016/S2095-4964(14)60001-7.
   PubMedGoogle Scholar
• Jansen, E., and T. Ruskovska. 2015. Serum biomarkers of (Anti)Oxidant Status for Epidemiological Studies. International Journal of Molecular Sciences 16 (11):27378–90. doi: 10.3390/ijms161126032.
   PubMed Web of Science ®Google Scholar
• Jayakumar, T., K. C. Lin, W. J. Lu, C. Y. Lin, G. Pitchairaj, J. Y. Li, and J. R. Sheu. 2017. Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms. International Journal of Molecular Medicine 39 (1):174–82. doi: 10.3892/ijmm.2016.2822.
   PubMed Web of Science ®Google Scholar
• Jayaraman, R., S. Subramani, S. H. Sheik Abdullah, and M. Udaiyar. 2018. Antihyperglycemic effect of hesperetin, a citrus flavonoid, extenuates hyperglycemia and exploring the potential role in antioxidant and antihyperlipidemic in streptozotocin-induced diabetic rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 97:98–106. doi: 10.1016/j.biopha.2017.10.102.
   PubMed Web of Science ®Google Scholar
• Jeon, S. M., S. H. Bok, M. K. Jang, M. K. Lee, K. T. Nam, Y. B. Park, S. J. Rhee, and M. S. Choi. 2001. Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. Life Sciences 69 (24):2855–66. doi: 10.1016/S0024-3205(01)01363-7.
   PubMed Web of Science ®Google Scholar
• Jeon, S. M., S. H. Bok, M. K. Jang, Y. H. Kim, K. T. Nam, T. S. Jeong, Y. B. Park, and M. S. Choi. 2002. Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits. Clinica Chimica Acta; International Journal of Clinical Chemistry 317 (1–2):181–90. doi: 10.1016/S0009-8981(01)00778-1.
   PubMed Web of Science ®Google Scholar
• Jiang, R., C. Lin, C. Jiang, Z. Huang, W. Gao, and D. Lin. 2020. Nobiletin enhances the survival of random pattern skin flaps: Involvement of enhancing angiogenesis and inhibiting oxidative stress. International Immunopharmacology 78:106010. doi: 10.1016/j.intimp.2019.106010.
   PubMed Web of Science ®Google Scholar
• Johnson, J., P. Maher, and A. Hanneken. 2009. The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression. Investigative Ophthalmology & Visual Science 50 (5):2398–406. doi: 10.1167/iovs.08-2088.
   PubMed Web of Science ®Google Scholar
• Justin Thenmozhi, A., T. R. William Raja, T. Manivasagam, U. Janakiraman, and M. M. Essa. 2017. Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer's disease. Nutritional Neuroscience 20 (6):360–8. doi: 10.1080/1028415X.2016.1144846.
   PubMed Web of Science ®Google Scholar
• Kamaraj, S., G. Ramakrishnan, P. Anandakumar, S. Jagan, and T. Devaki. 2009. Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice. Investigational New Drugs 27 (3):214–22. doi: 10.1007/s10637-008-9159-7.
   PubMed Web of Science ®Google Scholar
• Kamel, K. M., O. M. Abd El-Raouf, S. A. Metwally, H. A. Abd El-Latif, and M. E. El-Sayed. 2014. Hesperidin and rutin, antioxidant citrus flavonoids, attenuate cisplatin-induced nephrotoxicity in rats. Journal of Biochemical and Molecular Toxicology 28 (7):312–9. doi: 10.1002/jbt.21567.
   PubMed Web of Science ®Google Scholar
• Kamisli, S., O. Ciftci, K. Kaya, A. Cetin, O. Kamisli, and C. Ozcan. 2015. Hesperidin protects brain and sciatic nerve tissues against cisplatin-induced oxidative, histological and electromyographical side effects in rats. Toxicology and Industrial Health 31 (9):841–51. doi: 10.1177/0748233713483192.
   PubMed Web of Science ®Google Scholar
• Kanaze, F. I., A. Termentzi, C. Gabrieli, I. Niopas, M. Georgarakis, and E. Kokkalou. 2009. The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin. Biomedical Chromatography : BMC 23 (3):239–49. doi: 10.1002/bmc.1090.
   PubMed Web of Science ®Google Scholar
• Kang, M. I., A. Kobayashi, N. Wakabayashi, S. G. Kim, and M. Yamamoto. 2004. Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proceedings of the National Academy of Sciences of the United States of America 101 (7):2046–51. doi: 10.1073/pnas.0308347100.
   PubMed Web of Science ®Google Scholar
• Kanno, S., A. Shouji, K. Asou, and M. Ishikawa. 2003. Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. Journal of Pharmacological Sciences 92 (2):166–70. doi: 10.1254/jphs.92.166.
   PubMed Web of Science ®Google Scholar
• Karimi, E., E. Oskoueian, R. Hendra, A. Oskoueian, and H. Z. Jaafar. 2012. Phenolic compounds characterization and biological activities of Citrus aurantium bloom. Molecules (Basel, Switzerland) 17 (2):1203–18. doi: 10.3390/molecules17021203.
   PubMed Web of Science ®Google Scholar
• Kaur, G., N. Tirkey, and K. Chopra. 2006. Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity. Toxicology 226 (2–3):152–60. doi: 10.1016/j.tox.2006.06.018.
   PubMed Web of Science ®Google Scholar
• Khajevand-Khazaei, M. R., P. Ziaee, S. A. Motevalizadeh, M. Rohani, S. Afshin-Majd, T. Baluchnejadmojarad, and M. Roghani. 2018. Naringenin ameliorates learning and memory impairment following systemic lipopolysaccharide challenge in the rat. European Journal of Pharmacology 826:114–22. doi: 10.1016/j.ejphar.2018.03.001.
   PubMed Web of Science ®Google Scholar
• Kim, H. G., G. S. Kim, S. Park, J. H. Lee, O. N. Seo, S. J. Lee, J. H. Kim, J. H. Shim, A. M. Abd El-Aty, J. S. Jin, et al. 2012. Flavonoid profiling in three citrus varieties native to the Republic of Korea using liquid chromatography coupled with tandem mass spectrometry: Contribution to overall antioxidant activity. Biomedical Chromatography : BMC 26 (4):464–70. doi: 10.1002/bmc.1688.
   PubMed Web of Science ®Google Scholar
• Kim, T. W., D. R. Lee, B. K. Choi, H. K. Kang, J. Y. Jung, S. W. Lim, S. H. Yang, and J. W. Suh. 2016. Hepatoprotective effects of polymethoxyflavones against acute and chronic carbon tetrachloride intoxication. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 91:91–9. doi: 10.1016/j.fct.2016.03.004.
   PubMed Web of Science ®Google Scholar
• Kobayashi, A., M. I. Kang, H. Okawa, M. Ohtsuji, Y. Zenke, T. Chiba, K. Igarashi, and M. Yamamoto. 2004. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Molecular and Cellular Biology 24 (16):7130–9. doi: 10.1128/MCB.24.16.7130-7139.2004.
   PubMed Web of Science ®Google Scholar
• Krishna Chandran, A. M., H. Christina, S. Das, K. D. Mumbrekar, and B. S. Satish Rao. 2019. Neuroprotective role of naringenin against methylmercury induced cognitive impairment and mitochondrial damage in a mouse model. Environmental Toxicology and Pharmacology 71:103224. doi: 10.1016/j.etap.2019.103224.
   PubMed Web of Science ®Google Scholar
• Kulasekaran, G., and S. Ganapasam. 2015. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells. Molecular and Cellular Biochemistry 409 (1–2):199–211. doi: 10.1007/s11010-015-2525-9.
   PubMed Web of Science ®Google Scholar
• Kumar, A., S. Dogra, and A. Prakash. 2010. Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. Journal of Medicinal Food 13 (4):976–84. doi: 10.1089/jmf.2009.1251.
   PubMed Web of Science ®Google Scholar
• Kwak, M. K., N. Wakabayashi, and T. W. Kensler. 2004. Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutation Research-Fundamental and Molecular Mechanisms of. Mutation Research 555 (1–2):133–48. doi: 10.1016/j.mrfmmm.2004.06.041.
   PubMed Web of Science ®Google Scholar
• Lakshmi, A., and S. P. Subramanian. 2014b. Tangeretin ameliorates oxidative stress in the renal tissues of rats with experimental breast cancer induced by 7,12-dimethylbenz[a]anthracene. Toxicology Letters 229 (2):333–48. doi: 10.1016/j.toxlet.2014.06.845.
   PubMed Web of Science ®Google Scholar
• Lakshmi, A., and S. Subramanian. 2014a. Chemotherapeutic effect of tangeretin, a polymethoxylated flavone studied in 7, 12-dimethylbenz(a)anthracene induced mammary carcinoma in experimental rats. Biochimie 99:96–109. doi: 10.1016/j.biochi.2013.11.017.
   PubMed Web of Science ®Google Scholar
• Lee, S. E., H. Yang, G. W. Son, H. R. Park, C. S. Park, Y. H. Jin, and Y. S. Park. 2015. Eriodictyol protects endothelial cells against oxidative stress-induced cell death through modulating ERK/Nrf2/ARE-dependent heme oxygenase-1 expression. International Journal of Molecular Sciences 16 (7):14526–39. doi: 10.3390/ijms160714526.
   PubMed Web of Science ®Google Scholar
• Lee, Y. Y., E. J. Lee, J. S. Park, S. E. Jang, D. H. Kim, and H. S. Kim. 2016. Anti-inflammatory and antioxidant mechanism of tangeretin in activated microglia. Journal of Neuroimmune Pharmacology : The Official Journal of the Society on NeuroImmune Pharmacology 11 (2):294–305. doi: 10.1007/s11481-016-9657-x.
   PubMed Web of Science ®Google Scholar
• Lewinska, A., J. Adamczyk-Grochala, E. Kwasniewicz, A. Deregowska, and M. Wnuk. 2017. Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity. Toxicology Letters 265:117–30. doi: 10.1016/j.toxlet.2016.11.018.
   PubMed Web of Science ®Google Scholar
• Li, M., X. F. Lin, J. Lu, B. R. Zhou, and D. Luo. 2016. Hesperidin ameliorates UV radiation-induced skin damage by abrogation of oxidative stress and inflammatory in HaCaT cells. Journal of Photochemistry and Photobiology B: Biology 165:240–5. doi: 10.1016/j.jphotobiol.2016.10.037.
   PubMed Web of Science ®Google Scholar
• Liang, F., Y. Fang, W. Cao, Z. Zhang, S. Pan, and X. Xu. 2018. Attenuation of tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in HepG2 cells by tangeretin: relevance of the Nrf2-ARE and MAPK signaling pathways. Journal of Agricultural and Food Chemistry 66 (25):6317–25. doi: 10.1021/acs.jafc.8b01875.
   PubMed Web of Science ®Google Scholar
• Liew, S. S., W. Y. Ho, S. K. Yeap, and S. A. B. Sharifudin. 2018. Phytochemical composition and in vitro antioxidant activities of Citrus sinensis peel extracts. PeerJ 6:e5331. doi: 10.7717/peerj.5331.
   PubMed Web of Science ®Google Scholar
• Lim, W., S. Park, F. W. Bazer, and G. Song. 2017. Naringenin-induced apoptotic cell death in prostate cancer cells is mediated via the PI3K/AKT and MAPK signaling pathways. Journal of Cellular Biochemistry 118 (5):1118–31. doi: 10.1002/jcb.25729.
   PubMed Web of Science ®Google Scholar
• Ling, Y., Z. Shi, X. Yang, Z. Cai, L. Wang, X. Wu, A. Ye, and J. Jiang. 2020. Hypolipidemic effect of pure total flavonoids from peel of Citrus (PTFC) on hamsters of hyperlipidemia and its potential mechanism. Experimental Gerontology 130:110786. doi: 10.1016/j.exger.2019.110786.
   PubMed Web of Science ®Google Scholar
• Liu, L., and X. W. Wu. 2018. Nobiletin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage. Journal of Biochemical and Molecular Toxicology 32 (5):e22052. doi: 10.1002/jbt.22052.
   PubMed Web of Science ®Google Scholar
• Liu, W. Y., S. S. Liou, T. Y. Hong, and I. M. Liu. 2017a. The benefits of the citrus flavonoid diosmin on human retinal pigment epithelial cells under high-glucose conditions. Molecules 22 (12):2251. doi: 10.3390/molecules22122251.
   Web of Science ®Google Scholar
• Liu, W. Y., S. S. Liou, T. Y. Hong, and I. M. Liu. 2017b. Protective effects of hesperidin (Citrus flavonone) on high glucose induced oxidative stress and apoptosis in a cellular model for diabetic retinopathy. Nutrients 9 (12):1312. doi: 10.3390/nu9121312.
   PubMed Web of Science ®Google Scholar
• Liu, X., C. Zhao, Q. Gong, Y. Wang, J. Cao, X. Li, D. Grierson, and C. Sun. 2020b. Characterization of a caffeoyl-CoA O-methyltransferase-like enzyme involved in biosynthesis of polymethoxylated flavones in Citrus reticulata. Journal of Experimental Botany 71 (10):3066–79. doi: 10.1093/jxb/eraa083.
   PubMed Web of Science ®Google Scholar
• Liu, X., Y. Wang, Y. Chen, S. Xu, Q. Gong, C. Zhao, J. Cao, and C. Sun. 2020a. Characterization of a flavonoid 3’/5’/7-O-methyltransferase from Citrus reticulata and evaluation of the in vitro cytotoxicity of its methylated products. Molecules 25 (4):858. doi: 10.3390/molecules25040858.
   Web of Science ®Google Scholar
• Lobstein, T., R. Jackson-Leach, M. L. Moodie, K. D. Hall, S. L. Gortmaker, B. A. Swinburn, W. P. T. James, Y. Wang, and K. McPherson. 2015. Child and adolescent obesity: Part of a bigger picture. The Lancet 385 (9986):2510–20. doi: 10.1016/S0140-6736(14)61746-3.
   PubMed Web of Science ®Google Scholar
• Loizzo, M. R., R. Tundis, M. Bonesi, F. Menichini, D. De Luca, C. Colica, and F. Menichini. 2012. Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities. Journal of the Science of Food and Agriculture 92 (15):2960–7. doi: 10.1002/jsfa.5708.
   PubMed Web of Science ®Google Scholar
• Lou, S. N., Y. C. Lai, J. D. Huang, C. T. Ho, L. H. Ferng, and Y. C. Chang. 2015. Drying effect on flavonoid composition and antioxidant activity of immature kumquat. Food Chemistry 171:356–63. doi: 10.1016/j.foodchem.2014.08.119.
   PubMed Web of Science ®Google Scholar
• Lu, Q., S. Y. Lv, Y. Peng, C. H. Zhu, and S. Y. Pan. 2018. Characterization of phenolics and antioxidant abilities of red navel orange "Cara Cara" harvested from five regions of China. International Journal of Food Properties 21 (1):1107–16. doi: 10.1080/10942912.2018.1485030.
   Web of Science ®Google Scholar
• Lu, Y. H., M. Y. Su, H. Y. Huang, L. Lin, and C. G. Yuan. 2010. Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide. Neuroscience Letters 484:6–11. doi: 10.1016/j.neulet.2010.07.078.
   PubMed Web of Science ®Google Scholar
• Malik, S., J. Bhatia, K. Suchal, N. Gamad, A. K. Dinda, Y. K. Gupta, and D. S. Arya. 2015. Nobiletin ameliorates cisplatin-induced acute kidney injury due to its anti-oxidant, anti-inflammatory and anti-apoptotic effects. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie 67 (7–8):427–33. doi: 10.1016/j.etp.2015.04.008.
   PubMedGoogle Scholar
• Mani, S., S. Sekar, R. Barathidasan, T. Manivasagam, A. J. Thenmozhi, M. Sevanan, S. B. Chidambaram, M. M. Essa, G. J. Guillemin, and M. K. Sakharkar. 2018. Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson's Disease Model in Mice . Neurotoxicity Research 33 (3):656–70. doi: 10.1007/s12640-018-9869-3.
   PubMed Web of Science ®Google Scholar
• Manthey, J. A. 2004. Fractionation of orange peel phenols in ultrafiltered molasses and mass balance studies of their antioxidant levels. Journal of Agricultural and Food Chemistry 52 (25):7586–92. doi: 10.1021/jf049083j.
   PubMed Web of Science ®Google Scholar
• Martens, S., and A. Mithofer. 2005. Flavones and flavone synthases. Phytochemistry 66 (20):2399–407. doi: 10.1016/j.phytochem.2005.07.013.
   PubMed Web of Science ®Google Scholar
• Mershiba, S. D., M. V. Dassprakash, and S. D. Saraswathy. 2013. Protective effect of naringenin on hepatic and renal dysfunction and oxidative stress in arsenic intoxicated rats. Molecular Biology Reports 40 (5):3681–91. doi: 10.1007/s11033-012-2444-8.
   PubMed Web of Science ®Google Scholar
• Milella, L., M. Caruso, F. Galgano, F. Favati, M. C. Padula, and G. Martelli. 2011. Role of the cultivar in choosing Clementine fruits with a high level of health-promoting compounds. Journal of Agricultural and Food Chemistry 59 (10):5293–8. doi: 10.1021/jf104991z.
   PubMed Web of Science ®Google Scholar
• Miler, M., J. Zivanovic, V. Ajdzanovic, Z. Orescanin-Dusic, D. Milenkovic, A. Konic-Ristic, D. Blagojevic, V. Milosevic, and B. Sosic-Jurjevic. 2016. Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. Experimental Gerontology 84:49–60. doi: 10.1016/j.exger.2016.08.014.
   PubMed Web of Science ®Google Scholar
• Miyashita, T., A. Adhikari-Devkota, K. Hori, M. Watanabe, T. Watanabe, and H. P. Devkota. 2018. Flavonoids from the flowers of Citrus 'Hebesu. Natural Product Communications 13 (7):1934578X1801300714. doi: 10.1177/1934578X1801300714.
   Web of Science ®Google Scholar
• Mo’men, Y. S., R. M. Hussein, and M. A. Kandeil. 2019. Involvement of PI3K/Akt pathway in the protective effect of hesperidin against a chemically induced liver cancer in rats. Journal of Biochemical and Molecular Toxicology 33 (6) doi: 10.1002/jbt.22305.
   PubMed Web of Science ®Google Scholar
• Morand, C., C. Dubray, D. Milenkovic, D. Lioger, J. F. Martin, A. Scalbert, and A. Mazur. 2011. Hesperidin contributes to the vascular protective effects of orange juice: A randomized crossover study in healthy volunteers. The American Journal of Clinical Nutrition 93 (1):73–80. doi: 10.3945/ajcn.110.004945.
   PubMed Web of Science ®Google Scholar
• Morrow, R., F. Deyhim, B. S. Patil, and B. J. Stoecker. 2009. Feeding orange pulp improved bone quality in a rat model of male osteoporosis. Journal of Medicinal Food 12 (2):298–303. doi: 10.1089/jmf.2008.0145.
   PubMed Web of Science ®Google Scholar
• Muhammad, T., M. Ikram, R. Ullah, S. U. Rehman, and M. O. Kim. 2019. Hesperetin, a citrus flavonoid, attenuates LPS-induced neuroinflammation, apoptosis and memory impairments by modulating TLR4/NF-kappaB signaling. Nutrients 11 (3):648. doi: 10.3390/nu11030648.
   PubMed Web of Science ®Google Scholar
• Murakami, A., Y. Nakamura, K. Torikai, T. Tanaka, T. Koshiba, K. Koshimizu, S. Kuwahara, Y. Takahashi, K. Ogawa, M. Yano, et al. 2000b. Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. Cancer Research 60:5059–66.
   PubMed Web of Science ®Google Scholar
• Murakami, A., Y. Nakamura, Y. Ohto, M. Yano, T. Koshiba, K. Koshimizu, H. Tokuda, H. Nishino, and H. Ohigashi. 2000a. Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid. BioFactors (Oxford, England) 12 (1–4):187–92. doi: 10.1002/biof.5520120130.
   PubMed Web of Science ®Google Scholar
• Nakajima, A., Y. Aoyama, E. J. Shin, Y. Nam, H. C. Kim, T. Nagai, A. Yokosuka, Y. Mimaki, T. Yokoi, Y. Ohizumi, et al. 2015. Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)). Behavioural Brain Research 289:69–77. doi: 10.1016/j.bbr.2015.04.028.
   PubMed Web of Science ®Google Scholar
• Nakajima, A., Y. Aoyama, T. T. Nguyen, E. J. Shin, H. C. Kim, S. Yamada, T. Nakai, T. Nagai, A. Yokosuka, Y. Mimaki, et al. 2013. Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse. Behavioural Brain Research 250:351–60. doi: 10.1016/j.bbr.2013.05.025.
   PubMed Web of Science ®Google Scholar
• Nioi, P., M. McMahon, K. Itoh, M. Yamamoto, and J. D. Hayes. 2003. Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: Reassessment of the ARE consensus sequence. The Biochemical Journal 374 (Pt 2):337–48. doi: 10.1042/BJ20030754.
   PubMedGoogle Scholar
• Nkpaa, K. W., and G. I. Onyeso. 2018. Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats. Neuroscience Letters 682:92–9. doi: 10.1016/j.neulet.2018.06.023.
   PubMed Web of Science ®Google Scholar
• Nogata, Y., K. Sakamoto, H. Shiratsuchi, T. Ishii, M. Yano, and H. Ohta. 2006. Flavonoid composition of fruit tissues of citrus species. Bioscience, Biotechnology, and Biochemistry 70 (1):178–92. doi: 10.1271/bbb.70.178.
   PubMed Web of Science ®Google Scholar
• Overdevest, E., J. A. Wouters, K. H. M. Wolfs, J. J. M. van Leeuwen, and S. Possemiers. 2018. Citrus flavonoid supplementation improves exercise performance in trained athletes. Journal of Sports Science and Medicine 17:24–30.
   PubMed Web of Science ®Google Scholar
• Papoutsis, K., P. Pristijono, J. B. Golding, C. E. Stathopoulos, C. J. Scarlett, M. C. Bowyer, and Q. V. Vuong. 2016. Impact of different solvents on the recovery of bioactive compounds and antioxidant properties from lemon (Citrus limon L.) pomace waste. Food Science and Biotechnology 25 (4):971–7. doi: 10.1007/s10068-016-0158-8.
   PubMed Web of Science ®Google Scholar
• Pari, L., and K. Shagirtha. 2012. Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats. Experimental and Toxicologic Pathology 64 (5):513–20. doi: 10.1016/j.etp.2010.11.007.
   PubMedGoogle Scholar
• Pari, L., and M. Gnanasoundari. 2006. Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver. Basic & Clinical Pharmacology & Toxicology 98 (5):456–61. doi: 10.1111/j.1742-7843.2006.pto_351.x.
   PubMed Web of Science ®Google Scholar
• Piero, A. R. L., I. Puglisi, and G. Petrone. 2006. Gene characterization, analysis of expression and in vitro synthesis of dihydroflavonol 4-reductase from [Citrus sinensis (L.) Osbeck]. Phytochemistry 67 (7):684–95. doi: 10.1016/j.phytochem.2006.01.025.
   PubMed Web of Science ®Google Scholar
• Poor, M., B. Veres, P. B. Jakus, C. Antus, G. Montsko, Z. Zrinyi, S. Vladimir-Knezevic, J. Petrik, and T. Koszegi. 2014. Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A. Journal of Photochemistry and Photobiology B, Biology 132:1–9. doi: 10.1016/j.jphotobiol.2014.01.016.
   PubMed Web of Science ®Google Scholar
• Prabu, S. M., K. Shagirtha, and J. Renugadevi. 2011. Naringenin in combination with vitamins C and E potentially protects oxidative stress-mediated hepatic injury in cadmium-intoxicated rats. Journal of Nutritional Science and Vitaminology 57 (2):177–85. doi: 10.3177/jnsv.57.177.
   PubMed Web of Science ®Google Scholar
• Pradeep, K., K. C. Ko, M. H. Choi, J. A. Kang, Y. J. Chung, and S. H. Park. 2012. Protective effect of hesperidin, a citrus flavanoglycone, against γ-radiation-induced tissue damage in Sprague-Dawley rats . Journal of Medicinal Food 15 (5):419–27. doi: 10.1089/jmf.2011.1737.
   PubMed Web of Science ®Google Scholar
• Pradeep, K., S. H. Park, and K. C. Ko. 2008. Hesperidin a flavanoglycone protects against gamma-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats. European Journal of Pharmacology 587 (1–3):273–80. doi: 10.1016/j.ejphar.2008.03.052.
   PubMed Web of Science ®Google Scholar
• Proteggente, A. R., A. Saija, A. De Pasquale, and C. A. Rice-Evans. 2003. The compositional characterisation and antioxidant activity of fresh juices from Sicilian sweet orange (Citrus sinensis L. Osbeck) varieties. Free Radical Research 37 (6):681–7. doi: 10.1080/1071576031000083198.
   PubMed Web of Science ®Google Scholar
• Qu, Y., Y. Liu, L. Chen, Y. Zhu, X. Xiao, D. Wang, and Y. Zhu. 2018. Nobiletin prevents cadmium-induced neuronal apoptosis by inhibiting reactive oxygen species and modulating JNK/ERK1/2 and Akt/mTOR networks in rats. Neurological Research 40 (3):211–20. doi: 10.1080/01616412.2018.1424685.
   PubMed Web of Science ®Google Scholar
• Ramful, D., T. Bahorun, E. Bourdon, E. Tarnus, and O. I. Aruoma. 2010. Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: Potential prophylactic ingredients for functional foods application. Toxicology 278 (1):75–87. doi: 10.1016/j.tox.2010.01.012.
   PubMed Web of Science ®Google Scholar
• Rangel-Huerta, O. D., C. M. Aguilera, M. V. Martin, M. J. Soto, M. C. Rico, F. Vallejo, F. Tomas-Barberan, A. J. Perez-de-la-Cruz, A. Gil, and M. D. Mesa. 2015. Normal or High Polyphenol Concentration in Orange Juice Affects Antioxidant Activity, Blood Pressure, and Body Weight in Obese or Overweight Adults. The Journal of Nutrition 145 (8):1808–16. doi: 10.3945/jn.115.213660.
   PubMed Web of Science ®Google Scholar
• Rapavi, E., I. Kocsis, E. Feher, K. Szentmihalyi, A. Lugasi, E. Szekely, and A. Blazovics. 2007. The effect of citrus flavonoids on the redox state of alimentary-induced fatty liver in rats. Natural Product Research 21 (3):274–81. doi: 10.1080/14786410500518545.
   PubMed Web of Science ®Google Scholar
• Renugadevi, J., and S. M. Prabu. 2009. Naringenin protects against cadmium-induced oxidative renal dysfunction in rats. Toxicology 256 (1–2):128–34. doi: 10.1016/j.tox.2008.11.012.
   PubMed Web of Science ®Google Scholar
• Renugadevi, J., and S. M. Prabu. 2010. Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie 62 (2):171–81. doi: 10.1016/j.etp.2009.03.010.
   PubMed Web of Science ®Google Scholar
• Ribeiro, C. B., F. M. Ramos, J. A. Manthey, and T. B. Cesar. 2019. Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: A double-blind, randomized, controlled study. Phytotherapy Research : PTR 33 (7):1921–33. doi: 10.1002/ptr.6386.
   PubMed Web of Science ®Google Scholar
• Risitano, R., M. Curro, S. Cirmi, N. Ferlazzo, P. Campiglia, D. Caccamo, R. Ientile, and M. Navarra. 2014. Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes . PLoS One 9 (9):e107431. doi: 10.1371/journal.pone.0107431.
   PubMed Web of Science ®Google Scholar
• Riso, P., F. Visioli, C. Gardana, S. Grande, A. Brusamolino, F. Galvano, G. Galvano, and M. Porrini. 2005. Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stress. Journal of Agricultural and Food Chemistry 53 (4):941–7. doi: 10.1021/jf0485234.
   PubMed Web of Science ®Google Scholar
• Roy, A., A. Das, R. Das, S. Haldar, S. Bhattacharya, and P. K. Haldar. 2014. Naringenin, a citrus flavonoid, ameliorates arsenic-induced toxicity in Swiss albino mice. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer 33 (3):195–204. doi: 10.1615/jenvironpatholtoxicoloncol.2014010317.
   PubMed Web of Science ®Google Scholar
• Said, U. Z., H. N. Saada, M. S. Abd-Alla, M. E. Elsayed, and A. M. Amin. 2012. Hesperidin attenuates brain biochemical changes of irradiated rats. International Journal of Radiation Biology 88 (8):613–8. doi: 10.3109/09553002.2012.694008.
   PubMed Web of Science ®Google Scholar
• Saigusa, D., M. Shibuya, D. Jinno, H. Yamakoshi, Y. Iwabuchi, A. Yokosuka, Y. Mimaki, A. Naganuma, Y. Ohizumi, Y. Tomioka, et al. 2011. High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound. Analytical and Bioanalytical Chemistry 400 (10):3635–41. doi: 10.1007/s00216-011-5031-2.
   PubMed Web of Science ®Google Scholar
• Salden, B. N., F. J. Troost, E. de Groot, Y. R. Stevens, M. Garces-Rimon, S. Possemiers, B. Winkens, and A. A. Masclee. 2016. Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals. The American Journal of Clinical Nutrition 104 (6):1523–33. doi: 10.3945/ajcn.116.136960.
   PubMed Web of Science ®Google Scholar
• Samie, A., R. Sedaghat, T. Baluchnejadmojarad, and M. Roghani. 2018. Hesperetin, a citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosis. Life Sciences 210:132–9. doi: 10.1016/j.lfs.2018.08.074.
   PubMed Web of Science ®Google Scholar
• Satarug, S., S. H. Garrett, M. A. Sens, and D. A. Sens. 2010. Cadmium, environmental exposure, and health outcomes. Environmental Health Perspectives 118 (2):182–90. doi: 10.1289/ehp.0901234.
   PubMed Web of Science ®Google Scholar
• Saunt, J. 1990. Citrus varieties of the world. An illustrated guide. Norwich: Sinclair International Ltd.
   Google Scholar
• Selmi, S., K. Rtibi, D. Grami, H. Sebai, and L. Marzouki. 2017. Protective effects of orange (Citrus sinensis L.) peel aqueous extract and hesperidin on oxidative stress and peptic ulcer induced by alcohol in rat. Lipids in Health and Disease 16 (1):152. doi: 10.1186/s12944-017-0546-y.
   PubMedGoogle Scholar
• Shagirtha, K., and L. Pari. 2011. Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats. Ecotoxicology and Environmental Safety 74 (7):2105–11. doi: 10.1016/j.ecoenv.2011.06.002.
   PubMed Web of Science ®Google Scholar
• Shaik, N., M. Zbidah, and F. Lang. 2012. Inhibition of Ca(2+) entry and suicidal erythrocyte death by naringin. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 30 (3):678–86. doi: 10.1159/000341448.
   PubMedGoogle Scholar
• Shaikh, S., L. K. Bhatt, and K. Barve. 2019. Attenuation of isoproterenol-induced cardiotoxicity in rats by Narirutin rich fraction from grape fruit. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology 55:222–8. doi: 10.1016/j.phymed.2018.06.037.
   PubMed Web of Science ®Google Scholar
• Shen, C. Y., L. Wan, T. X. Wang, and J. G. Jiang. 2019. Citrus aurantium L. var. amara Engl. inhibited lipid accumulation in 3T3-L1 cells and Caenorhabditis elegans and prevented obesity in high-fat diet-fed mice. Pharmacological Research 147:104347. doi: 10.1016/j.phrs.2019.104347.
   PubMed Web of Science ®Google Scholar
• Shukla, K., H. Sonowal, A. Saxena, and K. V. Ramana. 2018. Didymin prevents hyperglycemia-induced human umbilical endothelial cells dysfunction and death. Biochemical Pharmacology 152:1–10. doi: 10.1016/j.bcp.2018.03.012.
   PubMed Web of Science ®Google Scholar
• Sies, H., C. Berndt, and D. P. Jones. 2017. Oxidative Stress. Annual Review of Biochemistry 86:715–48. doi: 10.1146/annurev-biochem-061516-045037.
   PubMed Web of Science ®Google Scholar
• Snyder, S. M., J. D. Reber, B. L. Freeman, K. Orgad, D. L. Eggett, and T. L. Parker. 2011. Controlling for sugar and ascorbic acid, a mixture of flavonoids matching navel oranges significantly increases human postprandial serum antioxidant capacity. Nutrition Research (New York, N.Y.) 31 (7):519–26. doi: 10.1016/j.nutres.2011.06.006.
   PubMed Web of Science ®Google Scholar
• Sommella, E., F. Pagano, G. Pepe, C. Ostacolo, M. Manfra, M. Chieppa, R. Di Sanzo, S. Carabetta, P. Campiglia, and M. Russo. 2017. Flavonoid composition of tarocco (Citrus sinensis L. Osbeck) clone "lempso" and fast antioxidant activity screening by DPPH-UHPLC-PDA-IT-TOF. Phytochemical Analysis : PCA 28 (6):521–8. doi: 10.1002/pca.2701.
   PubMed Web of Science ®Google Scholar
• Srinivasan, S., and L. Pari. 2012. Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. Chemico-Biological Interactions 195 (1):43–51. doi: 10.1016/j.cbi.2011.10.003.
   PubMed Web of Science ®Google Scholar
• Stocker, R. 2016. Antioxidant defenses in human blood plasma and extra-cellular fluids. Archives of Biochemistry and Biophysics 595:136–9. doi: 10.1016/j.abb.2015.11.021.
   PubMed Web of Science ®Google Scholar
• Su, J. D., J. H. Yen, S. M. Li, C. Y. Weng, M. H. Lin, C. T. Ho, and M. J. Wu. 2012. 3′,4′-didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells . Free Radical Biology & Medicine 52 (1):126–41. doi: 10.1016/j.freeradbiomed.2011.10.002.
   PubMed Web of Science ®Google Scholar
• Tarozzi, A., S. Hrelia, C. Angeloni, F. Morroni, P. Biagi, M. Guardigli, G. Cantelli-Forti, and P. Hrelia. 2006. Antioxidant effectiveness of organically and non-organically grown red oranges in cell culture systems. European Journal of Nutrition 45 (3):152–8. doi: 10.1007/s00394-005-0575-6.
   PubMed Web of Science ®Google Scholar
• Tirkey, N., S. Pilkhwal, A. Kuhad, and K. Chopra. 2005. Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacology 5 (1):2. doi: 10.1186/1471-2210-5-2.
   PubMedGoogle Scholar
• Tonin, F. S., L. M. Steimbach, A. Wiens, C. M. Perlin, and R. Pontarolo. 2015. Impact of natural juice consumption on plasma antioxidant status: A systematic review and meta-analysis. Molecules (Basel, Switzerland) 20 (12):22146–56. doi: 10.3390/molecules201219834.
   PubMed Web of Science ®Google Scholar
• Trombetta, D., F. Cimino, M. Cristani, G. Mandalari, A. Saija, G. Ginestra, A. Speciale, J. Chirafisi, G. Bisignano, K. Waldron, et al. 2010. In vitro protective effects of two extracts from bergamot peels on human endothelial cells exposed to tumor necrosis factor-alpha (TNF-alpha). Journal of Agricultural and Food Chemistry 58 (14):8430–6. doi: 10.1021/jf1008605.
   PubMed Web of Science ®Google Scholar
• Wang, F., Y. Huang, W. Wu, C. Zhu, R. Zhang, J. Chen, and J. Zeng. 2020. Metabolomics analysis of the peels of different colored citrus fruits (Citrus reticulata cv. 'Shatangju') during the maturation period based on UHPLC-QQQ-MS. Molecules 25 (2):396. doi: 10.3390/molecules25020396.
   Web of Science ®Google Scholar
• Wang, J. J., and P. Cui. 2013. Neohesperidin attenuates cerebral ischemia-reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway. Journal of Asian Natural Products Research 15 (9):1023–37. doi: 10.1080/10286020.2013.827176.
   PubMed Web of Science ®Google Scholar
• Wang, Y., J. Qian, J. P. Cao, D. L. Wang, C. R. Liu, R. X. Yang, X. Li, and C. D. Sun. 2017. Antioxidant capacity, anticancer ability and flavonoids composition of 35 citrus (Citrus reticulata Blanco) varieties. Molecules 22 (7):1114. doi: 10.3390/molecules22071114.
   PubMed Web of Science ®Google Scholar
• Wang, Y., S. Y. Ji, W. J. Zang, N. C. Wang, J. P. Cao, X. Li, and C. D. Sun. 2019. Identification of phenolic compounds from a unique citrus species, finger lime (Citrus australasica) and their inhibition of LPS-induced NO-releasing in BV-2 cell line. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 129:54–63. doi: 10.1016/j.fct.2019.04.006.
   PubMed Web of Science ®Google Scholar
• Wijesinghe, W. A., M. Senevirathne, M. C. Oh, and Y. J. Jeon. 2011. Protective effect of methanol extract from citrus press cakes prepared by far-infrared radiation drying on H(2)O(2)-mediated oxidative damage in Vero cells. Nutrition Research and Practice 5 (5):389–95. doi: 10.4162/nrp.2011.5.5.389.
   PubMed Web of Science ®Google Scholar
• Wilson, A. E., and L. Tian. 2019. Phylogenomic analysis of UDP-dependent glycosyltransferases provides insights into the evolutionary landscape of glycosylation in plant metabolism . The Plant Journal : For Cell and Molecular Biology 100 (6):1273–88. doi: 10.1111/tpj.14514.
   PubMed Web of Science ®Google Scholar
• Wojnar, W., M. Zych, and I. Kaczmarczyk-Sedlak. 2018. Antioxidative effect of flavonoid naringenin in the lenses of type 1 diabetic rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 108:974–84. doi: 10.1016/j.biopha.2018.09.092.
   PubMed Web of Science ®Google Scholar
• Wu, G. A., J. Terol, V. Ibanez, A. Lopez-Garcia, E. Perez-Roman, C. Borreda, C. Domingo, F. R. Tadeo, J. Carbonell-Caballero, R. Alonso, et al. 2018. Genomics of the origin and evolution of citrus. Nature 554 (7692):311–6. doi: 10.1038/nature25447.
   PubMed Web of Science ®Google Scholar
• Wunpathe, C., P. Potue, P. Maneesai, S. Bunbupha, P. Prachaney, U. Kukongviriyapan, V. Kukongviriyapan, and P. Pakdeechote. 2018. Hesperidin suppresses renin-angiotensin system mediated NOX2 over-expression and sympathoexcitation in 2K-1C hypertensive rats. The American Journal of Chinese Medicine 46 (4):751–67. doi: 10.1142/S0192415X18500398.
   PubMed Web of Science ®Google Scholar
• Xi, W., B. Fang, Q. Zhao, B. Jiao, and Z. Zhou. 2014. Flavonoid composition and antioxidant activities of Chinese local pummelo (Citrus grandis Osbeck.) varieties. Food Chemistry 161:230–8. doi: 10.1016/j.foodchem.2014.04.001.
   PubMed Web of Science ®Google Scholar
• Xi, W., G. Zhang, D. Jiang, and Z. Zhou. 2015. Phenolic compositions and antioxidant activities of grapefruit (Citrus paradisi Macfadyen) varieties cultivated in China. International Journal of Food Sciences and Nutrition 66 (8):858–66. doi: 10.3109/09637486.2015.1095864.
   PubMed Web of Science ®Google Scholar
• Xi, W., J. Lu, J. Qun, and B. Jiao. 2017. Characterization of phenolic profile and antioxidant capacity of different fruit part from lemon (Citrus limon Burm.) cultivars. Journal of Food Science and Technology 54 (5):1108–18. doi: 10.1007/s13197-017-2544-5.
   PubMed Web of Science ®Google Scholar
• Xie, G., X. Meng, F. Wang, Y. Bao, and J. Huo. 2017. Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2. Oncotarget 8 (40):68668–74. doi: 10.18632/oncotarget.19822.
   PubMedGoogle Scholar
• Xiong, Y., J. Qiu, C. Li, Y. Qiu, L. Guo, Y. Liu, J. Wan, Y. Li, G. Wu, L. Wang, et al. 2018. Fortunellin-induced modulation of phosphatase and tensin homolog by MicroRNA-374a decreases inflammation and maintains intestinal barrier function in colitis. Frontiers in Immunology 9:83. doi: 10.3389/fimmu.2018.00083.
   PubMed Web of Science ®Google Scholar
• Xu, C., J. Chen, J. Zhang, X. Hu, X. Zhou, Z. Lu, and H. Jiang. 2013. Naringenin inhibits angiotensin II-induced vascular smooth muscle cells proliferation and migration and decreases neointimal hyperplasia in balloon injured rat carotid arteries through suppressing oxidative stress. Biological and Pharmaceutical Bulletin 36 (10):1549–55. doi: 10.1248/bpb.b13-00247.
   PubMed Web of Science ®Google Scholar
• Yang, W. L., S. Y. Chen, C. Y. Ho, and G. C. Yen. 2020. Citrus flavonoids suppress IL-5 and ROS through distinct pathways in PMA/ionomycin-induced EL-4 cells. Food & Function 11 (1):824–33. doi: 10.1039/c9fo02815c.
   PubMed Web of Science ®Google Scholar
• Yilmaz, D., N. C. Aydemir, O. Vatan, E. Tuzun, and R. Bilaloglu. 2012. Influence of naringin on cadmium-induced genomic damage in human lymphocytes in vitro. Toxicology and Industrial Health 28 (2):114–21. doi: 10.1177/0748233711407241.
   PubMed Web of Science ®Google Scholar
• Yonekura-Sakakibara, K., Y. Higashi, and R. Nakabayashi. 2019. The Origin and Evolution of Plant Flavonoid Metabolism. Frontiers in Plant Science 10:943. doi: 10.3389/fpls.2019.00943.
   PubMed Web of Science ®Google Scholar
• Yoo, K. M., I. K. Hwang, J. H. Park, and B. Moon. 2009. Major phytochemical composition of 3 native Korean citrus varieties and bioactive activity on V79-4 cells induced by oxidative stress. Journal of Food Science 74 (6):C462–468. doi: 10.1111/j.1750-3841.2009.01229.x.
   PubMed Web of Science ®Google Scholar
• Yoon, J. H., T. G. Lim, K. M. Lee, A. J. Jeon, S. Y. Kim, and K. W. Lee. 2011. Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation. Journal of Agricultural and Food Chemistry 59 (1):222–8. doi: 10.1021/jf103204x.
   PubMed Web of Science ®Google Scholar
• Yu, E. A., G. S. Kim, J. E. Lee, S. Park, S. Yi, S. J. Lee, J. H. Kim, J. S. Jin, A. M. Abd El-Aty, J. H. Shim, et al. 2015. Flavonoid profiles of immature and mature fruit tissues of Citrus grandis Osbeck (Dangyuja) and overall contribution to the antioxidant effect. Biomedical Chromatography : BMC 29 (4):590–4. doi: 10.1002/bmc.3318.
   PubMed Web of Science ®Google Scholar
• Yu, L. M., X. Dong, J. Zhang, Z. Li, X. D. Xue, H. J. Wu, Z. L. Yang, Y. Yang, and H. S. Wang. 2019. Naringenin Attenuates Myocardial Ischemia-Reperfusion Injury via cGMP-PKGIα Signaling and In Vivo and In Vitro Studies . Oxidative Medicine and Cellular Longevity 2019:7670854. doi: 10.1155/2019/7670854.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Y. Sun, W. Xi, Y. Shen, L. Qiao, L. Zhong, X. Ye, and Z. Zhou. 2014. Phenolic compositions and antioxidant capacities of Chinese wild mandarin (Citrus reticulata Blanco) fruits. Food Chem 145:674–80. doi: 10.1016/j.foodchem.2013.08.012.
   PubMed Web of Science ®Google Scholar
• Zhao, C., X. Liu, Q. Gong, J. Cao, W. Shen, X. Yin, D. Grierson, B. Zhang, C. Xu, and X. Li. 2020. Three AP2/ERF family members modulate flavonoid synthesis by regulating type IV chalcone isomerase in citrus. Plant Biotechnology Journal 1–18. doi: 10.1111/pbi.13494.
   Web of Science ®Google Scholar
• Zhao, Z. Y., S. S. He, Y. Hu, Y. Yang, B. N. Jiao, Q. Fang, and Z. Q. Zhou. 2017. Fruit flavonoid variation between and within four cultivated Citrus species evaluated by UPLC-PDA system. Scientia Horticulturae 224:93–101. doi: 10.1016/j.scienta.2017.05.038.
   Web of Science ®Google Scholar
• Zheng, Y. Y., X. Zeng, W. Peng, Z. Wu, and W. W. Su. 2019. Characterisation and classification of Citri Reticulatae Pericarpium varieties based on UHPLC-Q-TOF-MS/MS combined with multivariate statistical analyses. Phytochemical Analysis : PCA 30 (3):278–91. doi: 10.1002/pca.2812.
   PubMed Web of Science ®Google Scholar
• Zielińska-Przyjemska, M., and E. Ignatowicz. 2008. Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism. Phytotherapy Research : PTR 22 (12):1557–62. doi: 10.1002/ptr.2449.
   PubMed Web of Science ®Google Scholar