482
Views
4
CrossRef citations to date
0
Altmetric
Reviews

Total, dietary, and supplemental calcium intake and risk of all-cause cardiovascular, and cancer mortality: a systematic review and dose-response meta-analysis of prospective cohort studies

, , , , &

References

  • Al-Delaimy, W. K., E. Rimm, W. C. Willett, M. J. Stampfer, and F. B. Hu. 2003. A prospective study of calcium intake from diet and supplements and risk of ischemic heart disease among men. The American Journal of Clinical Nutrition 77 (4):814–8. doi: 10.1093/ajcn/77.4.814.
  • Andersson, C., and R. S. Vasan. 2018. Epidemiology of cardiovascular disease in young individuals. Nature Reviews. Cardiology 15 (4):230–40. doi: 10.1038/nrcardio.2017.154.
  • Asemi, Z., P. Saneei, S. S. Sabihi, A. Feizi, and A. Esmaillzadeh. 2015. Total, dietary, and supplemental calcium intake and mortality from all-causes, cardiovascular disease, and cancer: A meta-analysis of observational studies. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD 25 (7):623–34. doi: 10.1016/j.numecd.2015.03.008.
  • Aune, D., D. A. Navarro Rosenblatt, D. S. M. Chan, A. R. Vieira, R. Vieira, D. C. Greenwood, L. J. Vatten, and T. Norat. 2015. Dairy products, calcium, and prostate cancer risk: A systematic review and meta-analysis of cohort studies. The American Journal of Clinical Nutrition 101 (1):87–117. doi: 10.3945/ajcn.113.067157.
  • Bero, L., N. Chartres, J. Diong, A. Fabbri, D. Ghersi, J. Lam, A. Lau, S. McDonald, B. Mintzes, P. Sutton, et al. 2018. The risk of bias in observational studies of exposures (ROBINS-E) tool: Concerns arising from application to observational studies of exposures. Systematic Reviews 7 (1):242 doi: 10.1186/s13643-018-0915-2.
  • Bonthuis, M., M. C. Hughes, T. I. Ibiebele, A. C. Green, and J. C. van der Pols. 2010. Dairy consumption and patterns of mortality of Australian adults. European journal of clinical nutrition 64 (6):569–77. doi: 10.1038/ejcn.2010.45.
  • Chan, R., J. Leung, and J. Woo. 2013. A prospective cohort study examining the associations of dietary calcium intake with all-cause and cardiovascular mortality in older Chinese community-dwelling people. PLoS One 8 (11):e80895. doi: 10.1371/journal.pone.0080895.
  • Chen, F., M. Du, J. B. Blumberg, K. K. Ho Chui, M. Ruan, G. Rogers, Z. Shan, L. Zeng, and F. F. Zhang. 2019. Association among dietary supplement use, nutrient intake, and mortality among U.S. adults: A cohort study. Annals of Internal Medicine 170 (9):604–13. doi: 10.7326/m18-2478.
  • Chung, M., A. M. Tang, Z. Fu, D. D. Wang, and S. J. Newberry. 2016. Calcium intake and cardiovascular disease risk: An updated systematic review and meta-analysis. Annals of Internal Medicine 165 (12):856–66. doi: 10.7326/m16-1165.
  • Dai, Q., X.-O. Shu, X. Deng, Y.-B. Xiang, H. Li, G. Yang, M. J. Shrubsole, B. Ji, H. Cai, W.-H. Chow, et al. 2013. Modifying effect of calcium/magnesium intake ratio and mortality: A population-based cohort study. BMJ Open 3 (2):e002111. doi: 10.1136/bmjopen-2012-002111.
  • Del Valle, H. B., A. L. Yaktine, C. L. Taylor, and A. C. Ross. 2011. Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press.
  • Dickinson, H. O., D. J. Nicolson, J. V. Cook, F. Campbell, F. R. Beyer, G. A. Ford, and J. Mason. 2006. Calcium supplementation for the management of primary hypertension in adults. Cochrane Database Syst Rev 19 (2):1–50. doi: 10.1002/14651858.CD004639.pub2.
  • Dik, V. K., N. Murphy, P. D. Siersema, V. Fedirko, M. Jenab, S. Y. Kong, C. P. Hansen, K. Overvad, A. Tjønneland, A. Olsen, et al. 2014. Prediagnostic intake of dairy products and dietary calcium and colorectal cancer survival-results from the EPIC cohort study. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 23 (9):1813–23. doi: 10.1158/1055-9965.epi-14-0172.
  • Draznin, B. 1988. Intracellular calcium, insulin secretion, and action. The American Journal of Medicine 85 (5a):44–58. doi: 10.1016/0002-9343(88)90397-X.
  • Giovannucci, E., Y. Liu, E. A. Platz, M. J. Stampfer, and W. C. Willett. 2007. Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. International Journal of Cancer 121 (7):1571–8. doi: 10.1002/ijc.22788.
  • Govers, M. J., and R. Van der Meet. 1993. Effects of dietary calcium and phosphate on the intestinal interactions between calcium, phosphate, fatty acids, and bile acids. Gut 34 (3):365–70. doi: 10.1136/gut.34.3.365.
  • Greenland, S., and M. P. Longnecker. 1992. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. American Journal of Epidemiology 135 (11):1301–9. doi: 10.1093/oxfordjournals.aje.a116237.
  • Hidayat, K., G. C. Chen, R. Zhang, X. Du, S. Y. Zou, B. M. Shi, and L. Q. Qin. 2016. Calcium intake and breast cancer risk: Meta-analysis of prospective cohort studies. The British Journal of Nutrition 116 (1):158–66. doi: 10.1017/s0007114516001768.
  • Jung, A. Y., X. Cai, K. Thoene, N. Obi, S. Jaskulski, S. Behrens, D. Flesch-Janys, and J. Chang-Claude. 2019. Antioxidant supplementation and breast cancer prognosis in postmenopausal women undergoing chemotherapy and radiation therapy. The American Journal of Clinical Nutrition 109 (1):69–78. doi: 10.1093/ajcn/nqy223.
  • Kaluza, J., N. Orsini, E. B. Levitan, A. Brzozowska, W. Roszkowski, and A. Wolk. 2010. Dietary calcium and magnesium intake and mortality: A prospective study of men. American Journal of Epidemiology 171 (7):801–7. doi: 10.1093/aje/kwp467.
  • Kendrick, J., A. K. Cheung, J. S. Kaufman, T. Greene, W. L. Roberts, G. Smits, and M. Chonchol. 2011. FGF-23 associates with death, cardiovascular events, and initiation of chronic dialysis. Journal of the American Society of Nephrology: JASN 22 (10):1913–22. doi: 10.1681/asn.2010121224.
  • Keum, N., D. H. Lee, D. C. Greenwood, X. Zhang, and E. L. Giovannucci. 2015. Calcium intake and colorectal adenoma risk: Dose-response meta-analysis of prospective observational studies. International Journal of Cancer 136 (7):1680–7. doi: 10.1002/ijc.29164.
  • Koh, K. A., H. D. Sesso, R. S. Paffenbarger, Jr., and I. M. Lee. 2006. Dairy products, calcium and prostate cancer risk. British Journal of Cancer 95 (11):1582–5. doi: 10.1038/sj.bjc.6603475.
  • Kong, S. H., J. H. Kim, A. R. Hong, N. H. Cho, and C. S. Shin. 2017. Dietary calcium intake and risk of cardiovascular disease, stroke, and fracture in a population with low calcium intake. The American Journal of Clinical Nutrition 106 (1):27–34. doi: 10.3945/ajcn.116.148171.
  • Langsetmo, L., C. Berger, N. Kreiger, C. S. Kovacs, D. A. Hanley, S. A. Jamal, S. J. Whiting, J. Genest, S. N. Morin, A. Hodsman, et al. 2013. Calcium and vitamin D intake and mortality: Results from the Canadian Multicentre Osteoporosis Study (CaMos). The Journal of Clinical Endocrinology and Metabolism 98 (7):3010–8. doi: 10.1210/jc.2013-1516.
  • Levitan, E. B., J. M. Shikany, A. Ahmed, L. G. Snetselaar, L. W. Martin, J. D. Curb, and C. E. Lewis. 2013. Calcium, magnesium and potassium intake and mortality in women with heart failure: The Women's Health Initiative. The British Journal of Nutrition 110 (1):179–85. doi: 10.1017/s0007114512004667.
  • Li, K., R. Kaaks, J. Linseisen, and S. Rohrmann. 2011. Dietary calcium and magnesium intake in relation to cancer incidence and mortality in a German prospective cohort (EPIC-Heidelberg). Cancer Causes & Control: CCC 22 (10):1375–82. doi: 10.1007/s10552-011-9810-z.
  • Li, K., R. Kaaks, J. Linseisen, and S. Rohrmann. 2012. Associations of dietary calcium intake and calcium supplementation with myocardial infarction and stroke risk and overall cardiovascular mortality in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition study (EPIC-Heidelberg).Heart (British Cardiac Society) 98 (12):920–5. doi: 10.1136/heartjnl-2011-301345.
  • Michaëlsson, K., H. Melhus, E. Warensjö Lemming, A. Wolk, and L. Byberg. 2013. Long term calcium intake and rates of all cause and cardiovascular mortality: Community based prospective longitudinal cohort study. BMJ 346 (feb12 4):f228–f228. doi: 10.1136/bmj.f228.
  • Moher, D., A. Liberati, J. Tetzlaff, and D. G. Altman. 2009. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. BMJ (Clinical Research ed.) 339:b2535. doi: 10.1136/bmj.b2535.
  • Orsini, N., R. Bellocco, and S. Greenland. 2006. Generalized least squares for trend estimation of summarized dose–response data. The Stata Journal: Promoting Communications on Statistics and Stata 6 (1):40–57. doi: 10.1177/1536867X0600600103.
  • Paik, J. M., G. C. Curhan, Q. Sun, K. M. Rexrode, J. E. Manson, E. B. Rimm, and E. N. Taylor. 2014. Calcium supplement intake and risk of cardiovascular disease in women. Osteoporosis International 25 (8):2047–56. doi: 10.1007/s00198-014-2732-3.
  • Park, Y., P. N. Mitrou, V. Kipnis, A. Hollenbeck, A. Schatzkin, and M. F. Leitzmann. 2007. Calcium, dairy foods, and risk of incident and fatal prostate cancer: The NIH-AARP Diet and Health Study. American Journal of Epidemiology 166 (11):1270–9. doi: 10.1093/aje/kwm268.
  • Pittas, A. G., J. Lau, F. B. Hu, and B. Dawson-Hughes. 2007. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. The Journal of Clinical Endocrinology and Metabolism 92 (6):2017–29. doi: 10.1210/jc.2007-0298.
  • Prentice, R. L., M. B. Pettinger, R. D. Jackson, J. Wactawski-Wende, A. Z. Lacroix, G. L. Anderson, R. T. Chlebowski, J. E. Manson, L. Van Horn, M. Z. Vitolins, et al. 2013. Health risks and benefits from calcium and vitamin D supplementation: Women's Health Initiative clinical trial and cohort study. Osteoporosis International: A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 24 (2):567–80. doi: 10.1007/s00198-012-2224-2.
  • Provan, S. A., I. C. Olsen, C. Austad, G. Haugeberg, T. K. Kvien, and T. Uhlig. 2017. Calcium supplementation and inflammation increase mortality in rheumatoid arthritis: A 15-year cohort study in 609 patients from the Oslo Rheumatoid Arthritis Register. Seminars in Arthritis and Rheumatism 46 (4):411–7. doi: 10.1016/j.semarthrit.2016.07.011.
  • Raffield, L. M., S. Agarwal, A. J. Cox, F.-C. Hsu, J. J. Carr, B. I. Freedman, J. Xu, D. W. Bowden, and M. Z. Vitolins. 2014. Cross-sectional analysis of calcium intake for associations with vascular calcification and mortality in individuals with type 2 diabetes from the Diabetes Heart Study. The American Journal of Clinical Nutrition 100 (4):1029–35. doi: 10.3945/ajcn.114.090365.
  • Rautiainen, S., L. Wang, J. E. Manson, and H. D. Sesso. 2013. The role of calcium in the prevention of cardiovascular disease-a review of observational studies and randomized clinical trials. Current Atherosclerosis Reports 15 (11):362. doi: 10.1007/s11883-013-0362-4.
  • Rodríguez, A. J., D. Scott, B. Khan, A. Hodge, D. R. English, G. G. Giles, B. Abrahamsen, and P. R. Ebeling. 2018. High calcium intake in men not women is associated with all-cause mortality risk: Melbourne Collaborative Cohort Study. Archives of Osteoporosis 13 (1):101. doi: 10.1007/s11657-018-0518-5.
  • Ross, A. C., J. E. Manson, S. A. Abrams, J. F. Aloia, P. M. Brannon, S. K. Clinton, R. A. Durazo-Arvizu, J. C. Gallagher, R. L. Gallo, G. Jones, et al. 2011. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know. The Journal of Clinical Endocrinology and Metabolism 96 (1):53–8. doi: 10.1210/jc.2010-2704.
  • Saquib, J., C. Rock, L. Natarajan, N. Saquib, V. Newman, R. Patterson, C. Thomson, W. Al-Delaimy, and J. Pierce. 2011. Dietary intake, supplement use, and survival among women diagnosed with early-stage breast cancer. Nutrition and Cancer 63 (3):327–33. doi: 10.1080/01635581.2011.535957.
  • Slob, I. C., J. L. Lambregts, A. J. Schuit, and F. J. Kok. 1993. Calcium intake and 28-year gastro-intestinal cancer mortality in Dutch civil servants. International Journal of Cancer 54 (1):20–5. doi: 10.1002/ijc.2910540105.
  • Soares, M. J., L. L. Murhadi, A. V. Kurpad, W. L. Chan She Ping-Delfos, and L. S. Piers. 2012. Mechanistic roles for calcium and vitamin D in the regulation of body weight. Obesity Reviews: An Official Journal of the International Association for the Study of Obesity 13 (7):592–605. doi: 10.1111/j.1467-789X.2012.00986.x.
  • Stasinopoulos, L. C., A. Zhou, and E. Hypponen. 2020. Association of supplemental calcium and dairy milk intake with all-cause and cause-specific mortality in the UK Biobank: A prospective cohort study. British Journal of Nutrition 123 (5):574–82. doi: 10.1017/S0007114519003076.
  • Talaei, M., W. P. Koh, J. M. Yuan, and R. M. van Dam. 2019. DASH dietary pattern, mediation by mineral intakes, and the risk of coronary artery disease and stroke mortality. Journal of the American Heart Association 8 (5):1–10. doi: 10.1161/JAHA.118.011054.
  • Tao, M.-H., Q. Dai, A. E. Millen, J. Nie, S. B. Edge, M. Trevisan, P. G. Shields, and J. L. Freudenheim. 2016. Associations of intakes of magnesium and calcium and survival among women with breast cancer: Results from Western New York Exposures and Breast Cancer (WEB) Study. American Journal of Cancer Research 6 (1):105–13.
  • Um, C. Y., S. E. Judd, W. D. Flanders, V. Fedirko, and R. M. Bostick. 2017. Associations of calcium and dairy products with all-cause and cause-specific mortality in the REasons for Geographic and Racial Differences in Stroke (REGARDS) prospective cohort study. Nutrition and Cancer 69 (8):1185–95. doi: 10.1080/01635581.2017.1367946.
  • Um, C. Y., A. Prizment, C. P. Hong, D. Lazovich, and R. M. Bostick. 2019. Associations of calcium and dairy product intakes with all-cause, all-cancer, colorectal cancer and CHD mortality among older women in the Iowa Women's Health Study. The British Journal of Nutrition 121 (10):1188–200. doi: 10.1017/s000711451900045x.
  • Umesawa, M., H. Iso, C. Date, A. Yamamoto, H. Toyoshima, Y. Watanabe, S. Kikuchi, A. Koizumi, T. Kondo, Y. Inaba, et al. 2006. Dietary intake of calcium in relation to mortality from cardiovascular disease: The JACC Study. Stroke 37 (1):20–6. doi: 10.1161/01.str.0000195155.21143.38.
  • Van der Vijver, L. P., M. A. van der Waal, K. G. Weterings, J. M. Dekker, E. G. Schouten, and F. J. Kok. 1992. Calcium intake and 28-year cardiovascular and coronary heart disease mortality in Dutch civil servants. International Journal of Epidemiology 21 (1):36–9. doi: 10.1093/ije/21.1.36.
  • Van Hemelrijck, M., K. Michaelsson, J. Linseisen, and S. Rohrmann. 2013. Calcium intake and serum concentration in relation to risk of cardiovascular death in NHANES III. PLoS One 8 (4):e61037. doi: 10.1371/journal.pone.0061037.
  • van Mierlo, L. A., L. R. Arends, M. T. Streppel, M. P. Zeegers, F. J. Kok, D. E. Grobbee, and J. M. Geleijnse. 2006. Blood pressure response to calcium supplementation: A meta-analysis of randomized controlled trials. Journal of Human Hypertension 20 (8):571–80. doi: 10.1038/sj.jhh.1002038.
  • Vervloet, M. G., F. J. van Ittersum, R. M. Büttler, A. C. Heijboer, M. A. Blankenstein, and P. M. ter Wee. 2011. Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. Clinical Journal of the American Society of Nephrology 6 (2):383–9. doi: 10.2215/CJN.04730510.
  • Wang, X., H. Chen, Y. Ouyang, J. Liu, G. Zhao, W. Bao, and M. Yan. 2014. Dietary calcium intake and mortality risk from cardiovascular disease and all causes: A meta-analysis of prospective cohort studies. BMC Medicine 12 (1):158. doi: 10.1186/s12916-014-0158-6.
  • Wesselink, E., D. E. Kok, M. J. L. Bours, J. H. W. de Wilt, H. van Baar, M. van Zutphen, A. M. J. R. Geijsen, E. T. P. Keulen, B. M. E. Hansson, J. van den Ouweland, et al. 2020. Vitamin D, magnesium, calcium, and their interaction in relation to colorectal cancer recurrence and all-cause mortality. The American Journal of Clinical Nutrition 111 (5):1007–17. doi: 10.1093/ajcn/nqaa049.
  • Wilson, K. M., I. M. Shui, L. A. Mucci, and E. Giovannucci. 2015. Calcium and phosphorus intake and prostate cancer risk: A 24-y follow-up study. The American Journal of Clinical Nutrition 101 (1):173–83. doi: 10.3945/ajcn.114.088716.
  • Xiao, Q., R. A. Murphy, D. K. Houston, T. B. Harris, W. H. Chow, and Y. Park. 2013. Dietary and supplemental calcium intake and cardiovascular disease mortality: The National Institutes of Health-AARP diet and health study. JAMA Internal Medicine 173 (8):639–46. doi: 10.1001/jamainternmed.2013.3283.
  • Yang, B., P. T. Campbell, S. M. Gapstur, E. J. Jacobs, R. M. Bostick, V. Fedirko, W. D. Flanders, and M. L. McCullough. 2016. Calcium intake and mortality from all causes, cancer, and cardiovascular disease: The Cancer Prevention Study II Nutrition Cohort. The American Journal of Clinical Nutrition 103 (3):886–94. doi: 10.3945/ajcn.115.117994.
  • Yang, W., Y. Ma, S. Smith-Warner, M. Song, K. Wu, M. Wang, A. T. Chan, S. Ogino, C. S. Fuchs, V. Poylin, et al. 2019. Calcium intake and survival after colorectal cancer diagnosis. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 25 (6):1980–8. doi: 10.1158/1078-0432.ccr-18-2965.
  • Yu, D., Y. Takata, S. A. Smith-Warner, W. Blot, N. Sawada, E. White, N. Freedman, K. Robien, E. Giovannucci, X. Zhang, et al. 2017. Prediagnostic calcium intake and lung cancer survival: A pooled analysis of 12 cohort studies. Cancer Epidemiology Biomarkers & Prevention 26 (7):1060–70. doi: 10.1158/1055-9965.EPI-16-0863.
  • Zemel, M. B. 1998. Nutritional and endocrine modulation of intracellular calcium: Implications in obesity, insulin resistance and hypertension. Molecular and Cellular Biochemistry 188 (1-2):129–36.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.