The biological activities of postbiotics in gastrointestinal disorders

References

• Abbasi, A., A. Aghebati-Maleki, M. Yousefi, and L. Aghebati-Maleki. 2021. Probiotic intervention as a potential therapeutic for managing gestational disorders and improving pregnancy outcomes. Journal of Reproductive Immunology 143:103244. doi: 10.1016/j.jri.2020.103244.
   PubMed Web of Science ®Google Scholar
• Abbasi, A., N. Hajipour, P. Hasannezhad, A. Baghbanzadeh, and L. Aghebati-Maleki. 2020. Potential in vivo delivery routes of postbiotics. Critical Reviews in Food Science and Nutrition :1–39. doi: 10.1080/10408398.2020.1865260.
   PubMed Web of Science ®Google Scholar
• Aguilar-Toalá, J., R. Garcia-Varela, H. Garcia, V. Mata-Haro, A. González-Córdova, B. Vallejo-Cordoba, and A. Hernández-Mendoza. 2018. Postbiotics: An evolving term within the functional foods field. Trends in Food Science & Technology 75:105–14. doi: 10.1016/j.tifs.2018.03.009.
   Web of Science ®Google Scholar
• Aiba, Y., H. Ishikawa, M. Tokunaga, and Y. Komatsu. 2017. Anti-Helicobacter pylori activity of non-living, heat-killed form of lactobacilli including Lactobacillus johnsonii No.1088. FEMS Microbiology Letters 364 (11):1–5. doi: 10.1093/femsle/fnx102.
   Web of Science ®Google Scholar
• Al Nabhani, Z., S. Dulauroy, R. Marques, C. Cousu, S. Al Bounny, F. Déjardin, T. Sparwasser, M. Bérard, N. Cerf-Bensussan, and G. Eberl. 2019. A weaning reaction to microbiota is required for resistance to immunopathologies in the adult. Immunity 50 (5):1276–88. e1275. doi: 10.1016/j.immuni.2019.02.014.
   PubMed Web of Science ®Google Scholar
• Albarracin, L., H. Kobayashi, H. Iida, N. Sato, T. Nochi, H. Aso, S. Salva, S. Alvarez, H. Kitazawa, and J. Villena. 2017. Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells: Influence of immunobiotic Lactobacilli. Frontiers in Immunology 8:57. doi: 10.3389/fimmu.2017.00057.
   PubMed Web of Science ®Google Scholar
• Amaretti, A., M. di Nunzio, A. Pompei, S. Raimondi, M. Rossi, and A. Bordoni. 2013. Antioxidant properties of potentially probiotic bacteria: In vitro and in vivo activities. Applied Microbiology and Biotechnology 97 (2):809–17. doi: 10.1007/s00253-012-4241-7.
   PubMed Web of Science ®Google Scholar
• Anwar, F., H. N. Altayb, F. A. Al-Abbasi, A. L. Al-Malki, M. A. Kamal, andV. Kumar. 2020. Antiviral effects of probiotic metabolites on COVID-19. Journal of Biomolecular Structure and Dynamics 9:1–10. doi: 10.1080/07391102.2020.1775123. PMC: 32475223.
   Web of Science ®Google Scholar
• Appel-da-Silva, M. C., G. A. Narvaez, L. R. Perez, L. Drehmer, and J. Lewgoy. 2017. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. Medical Mycology Case Reports 18:15–7. doi: 10.1016/j.mmcr.2017.07.007.
   PubMed Web of Science ®Google Scholar
• Arai, S., N. Iwabuchi, S. Takahashi, J-z Xiao, F. Abe, and S. Hachimura. 2018. Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice. PloS One 13 (6):e0199018. doi: 10.1371/journal.pone.0199018.
   PubMed Web of Science ®Google Scholar
• Bali, V., P. S. Panesar, and M. B. Bera. 2016. Trends in utilization of agro-industrial byproducts for production of bacteriocins and their biopreservative applications. Critical Reviews in Biotechnology 36 (2):204–14. doi: 10.3109/07388551.2014.947916.
   PubMed Web of Science ®Google Scholar
• Barbosa, R. S., and M. A. Vieira-Coelho. 2020. Probiotics and prebiotics: Focus on psychiatric disorders–a systematic review. Nutrition Reviews 78 (6):437–50. doi: 10.1093/nutrit/nuz080.
   PubMed Web of Science ®Google Scholar
• Barros, C. P., J. T. Guimarães, E. A. Esmerino, M. C. K. Duarte, M. C. Silva, R. Silva, B. M. Ferreira, A. S. Sant’Ana, M. Q. Freitas, and A. G. Cruz. 2020. Paraprobiotics and postbiotics: Concepts and potential applications in dairy products. Current Opinion in Food Science 32:1–8. doi: 10.1016/j.cofs.2019.12.003.
   Web of Science ®Google Scholar
• Bermudez-Brito, M., J. Plaza-Díaz, S. Munoz-Quezada, C. Gomez-Llorente, and A. Gil. 2012. Probiotic mechanisms of action. Annals of Nutrition & Metabolism 61 (2):160–74. doi: 10.1159/000342079.
   PubMed Web of Science ®Google Scholar
• Bertelli, C., T. Pillonel, A. Torregrossa, G. Prod'hom, C. J. Fischer, G. Greub, and E. Giannoni. 2015. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America 60 (6):924–7. doi: 10.1093/cid/ciu946.
   PubMed Web of Science ®Google Scholar
• Bianchi, F., M. Dall’Asta, D. Del Rio, A. Mangia, M. Musci, and F. Scazzina. 2011. Development of a headspace solid-phase microextraction gas chromatography–mass spectrometric method for the determination of short-chain fatty acids from intestinal fermentation. Food Chemistry 129 (1):200–5. doi: 10.1016/j.foodchem.2011.04.022.
   Web of Science ®Google Scholar
• Bozzi Cionci, N., L. Baffoni, F. Gaggìa, and D. Di Gioia. 2018. Therapeutic microbiology: The Role of Bifidobacterium breve as food supplement for the prevention/treatment of paediatric diseases. Nutrients 10 (11):1723. doi: 10.3390/nu10111723.
   PubMed Web of Science ®Google Scholar
• Burta, O., C. Iacobescu, R. B. Mateescu, T. Nicolaie, N. Tiuca, and C. S. Pop. 2018. Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: A multicentre, randomised, double-blind, parallel group, clinical study. Translational Gastroenterology and Hepatology 3:72. doi: 10.21037/tgh.2018.09.11.
   PubMed Web of Science ®Google Scholar
• Burton, J. P., B. K. Drummond, C. N. Chilcott, J. R. Tagg, W. M. Thomson, J. D. Hale, and P. A. Wescombe. 2013. Influence of the probiotic Streptococcus salivarius strain M18 on indices of dental health in children: A randomized double-blind, placebo-controlled trial. Journal of Medical Microbiology 62 (Pt 6):875–884. doi: 10.1099/jmm.0.056663-0.
   PubMedGoogle Scholar
• Campeotto, F., A. Suau, N. Kapel, F. Magne, V. Viallon, L. Ferraris, A.-J. Waligora-Dupriet, P. Soulaines, B. Leroux, N. Kalach, et al. 2011. A fermented formula in pre-term infants: Clinical tolerance, gut microbiota, down-regulation of faecal calprotectin and up-regulation of faecal secretory IgA. The British Journal of Nutrition 105 (12):1843–1851. doi: 10.1017/S0007114510005702.
   PubMed Web of Science ®Google Scholar
• Campeotto, F., A. Suau, N. Kapel, F. Magne, V. Viallon, L. Ferraris, A.-J. Waligora-Dupriet, P. Soulaines, B. Leroux, N. Kalach, et al. 2011. A fermented formula in pre-term infants: Clinical tolerance, gut microbiota, down-regulation of faecal calprotectin and up-regulation of faecal secretory IgA. The British Journal of Nutrition 105 (12):1843–1851. doi: 10.1017/S0007114510005702.
   PubMed Web of Science ®Google Scholar
• Castro-Bravo, N., J. M. Wells, A. Margolles, andP. Ruas-Madiedo. 2018. Interactions of Surface Exopolysaccharides From Bifidobacterium and Lactobacillus Within the Intestinal Environment. Frontiers in Microbiology 9:2426. doi: 10.3389/fmicb.2018.02426. PMC: 30364185.
   PubMed Web of Science ®Google Scholar
• Chen, D., D. Jin, S. Huang, J. Wu, M. Xu, T. Liu, W. Dong, X. Liu, S. Wang, W. Zhong, et al. 2020. Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota. Cancer Letters 469:456–467. doi: 10.1016/j.canlet.2019.11.019.
   PubMed Web of Science ®Google Scholar
• Chen, C.-Y., H.-Y. Tsen, C.-L. Lin, C.-K. Lin, L.-T. Chuang, C.-S. Chen, and Y.-C. Chiang. 2013. Enhancement of the immune response against Salmonella infection of mice by heat-killed multispecies combinations of lactic acid bacteria. Journal of Medical Microbiology 62 (Pt 11):1657–1664. doi: 10.1099/jmm.0.061010-0.
   PubMedGoogle Scholar
• Chuah, L.-O., H. L. Foo, T. C. Loh, N. B. M. Alitheen, S. K. Yeap, N. E. A. Mutalib, R. A. Rahim, and K. Yusoff. 2019. Postbiotic metabolites produced by Lactobacillus plantarum strains exert selective cytotoxicity effects on cancer cells. BMC Complementary and Alternative Medicine 19 (1):114. doi: 10.1186/s12906-019-2528-2.
   PubMedGoogle Scholar
• Chuang, L., K.-G. Wu, C. Pai, P.-S. Hsieh, J.-J. Tsai, J.-H. Yen, and M.-Y. Lin. 2007. Heat-killed cells of lactobacilli skew the immune response toward T helper 1 polarization in mouse splenocytes and dendritic cell-treated T cells. Journal of Agricultural and Food Chemistry 55 (26):11080–11086. doi: 10.1021/jf071786o.
   PubMed Web of Science ®Google Scholar
• Cicenia, A., A. Scirocco, M. Carabotti, L. Pallotta, M. Marignani, and C. Severi. 2014. Postbiotic activities of lactobacilli-derived factors. Journal of Clinical Gastroenterology 48 (Supplement 1):S18–S22. doi: 10.1097/MCG.0000000000000231.
   PubMedGoogle Scholar
• Cohen, P. A. 2018. Probiotic safety-no guarantees. JAMA Internal Medicine 178 (12):1577–1578. doi: 10.1001/jamainternmed.2018.5403.
   PubMed Web of Science ®Google Scholar
• Compare, D., A. Rocco, P. Coccoli, D. Angrisani, C. Sgamato, B. Iovine, U. Salvatore, and G. Nardone. 2017. Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: An ex-vivo organ culture model of post-infectious irritable bowel syndrome. BMC Gastroenterology 17 (1):53. doi: 10.1186/s12876-017-0605-x.
   PubMedGoogle Scholar
• Corr, S. C., Y. Li, C. U. Riedel, P. W. O'Toole, C. Hill, and C. G. Gahan. 2007. Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118. Proceedings of the National Academy of Sciences 104 (18):7617–7621. doi: 10.1073/pnas.0700440104.
   PubMed Web of Science ®Google Scholar
• Cuevas-González, P., A. Liceaga, and J. Aguilar-Toalá. 2020. Postbiotics and Paraprobiotics: From concepts to applications. Food Research International 136:109502. doi: 10.1016/j.foodres.2020.109502.
   PubMed Web of Science ®Google Scholar
• Daelemans, S., L. Peeters, B. Hauser, and Y. Vandenplas. 2018. Recent advances in understanding and managing infantile colic. F1000Research 7:1426. doi: 10.12688/f1000research.14940.1.
   Google Scholar
• Davis, C. D., and J. A. Milner. 2009. Gastrointestinal microflora, food components and colon cancer prevention. Journal of Nutritional Biochemistry 20 (10):743–752. doi: 10.1016/j.jnutbio.2009.06.001.
   PubMed Web of Science ®Google Scholar
• de Almada, C. N., C. N. Almada, R. C. Martinez, and A. S. Sant'Ana. 2016. Paraprobiotics: Evidences on their ability to modify biological responses, inactivation methods and perspectives on their application in foods. Trends in Food Science & Technology 58:96–114. doi: 10.1016/j.tifs.2016.09.011.
   Web of Science ®Google Scholar
• De Marco, S., M. Sichetti, D. Muradyan, M. Piccioni, G. Traina, R. Pagiotti, and D. Pietrella. ( 2018. 2018). Probiotic cell-free supernatants exhibited anti-inflammatory and antioxidant activity on human gut epithelial cells and macrophages stimulated with LPS. Evidence-Based Complementary and Alternative Medicine 2018:1–12. doi: 10.1155/2018/1756308.
   Web of Science ®Google Scholar
• Decuypere, J. A., and N. A. Dierick. 2003. The combined use of triacylglycerols containing medium-chain fatty acids and exogenous lipolytic enzymes as an alternative to in-feed antibiotics in piglets: Concept, possibilities and limitations. An overview. Nutrition Research Reviews 16 (2):193–210. doi: 10.1079/NRR200369.
   PubMed Web of Science ®Google Scholar
• Denev, P., M. Kratchanova, M. Ciz, A. Lojek, O. Vasicek, P. Nedelcheva, D. Blazheva, R. Toshkova, E. Gardeva, L. Yossifova, et al. 2014. Biological activities of selected polyphenol-rich fruits related to immunity and gastrointestinal health. Food Chemistry 157:37–44. doi: 10.1016/j.foodchem.2014.02.022.
   PubMed Web of Science ®Google Scholar
• Desrouillères, K., M. Millette, M. Jamshidian, B. Maherani, O. Fortin, and M. Lacroix. 2016. Cancer preventive effect of a specific probiotic fermented milk components and cell walls extracted from a biomass containing L. acidophilus CL1285, L. casei LBC80R, and L. rhamnosus CLR2 on male F344 rats treated with 1,2-dimethylhydrazine. Journal of Functional Foods 26:373–384. doi: 10.1016/j.jff.2016.08.005.
   Web of Science ®Google Scholar
• Devirgiliis, C., P. Zinno, and G. Perozzi. 2013. Update on antibiotic resistance in foodborne Lactobacillus and Lactococcus species. Frontiers in Microbiology 4:301. doi: 10.3389/fmicb.2013.00301.
   PubMed Web of Science ®Google Scholar
• Di Cerbo, A., B. Palmieri, M. Aponte, J. C. Morales-Medina, and T. Iannitti. 2016. Mechanisms and therapeutic effectiveness of lactobacilli. Journal of Clinical Pathology 69 (3):187–203. doi: 10.1136/jclinpath-2015-202976.
   PubMed Web of Science ®Google Scholar
• Dinić, M., J. Lukić, J. Djokić, M. Milenković, I. Strahinić, N. Golić, and J. Begović. 2017. Lactobacillus fermentum postbiotic-induced autophagy as potential approach for treatment of acetaminophen hepatotoxicity. Frontiers in Microbiology 8:594. doi: 10.3389/fmicb.2017.00594.
   PubMed Web of Science ®Google Scholar
• do Carmo, M. S., C. Itapary dos Santos, M. C. Araújo, J. A. Girón, E. S. Fernandes, and V. Monteiro-Neto. 2018. Probiotics, mechanisms of action, and clinical perspectives for diarrhea management in children. Food & Function 9 (10):5074–5095. doi: 10.1039/c8fo00376a.
   PubMed Web of Science ®Google Scholar
• Doern, C. D., S. T. Nguyen, F. Afolabi, and C.-A D. Burnham. 2014. Probiotic-associated aspiration pneumonia due to Lactobacillus rhamnosus. Journal of Clinical Microbiology 52 (8):3124–3126. doi: 10.1128/JCM.01065-14.
   PubMed Web of Science ®Google Scholar
• Donohoe, D. R., L. B. Collins, A. Wali, R. Bigler, W. Sun, and S. J. Bultman. 2012. The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Molecular Cell 48 (4):612–626. doi: 10.1016/j.molcel.2012.08.033.
   PubMed Web of Science ®Google Scholar
• Doron, S., and D. R. Snydman. 2015. Risk and safety of probiotics. Clinical Infectious Diseases 60 (suppl_2):S129–S134. doi: 10.1093/cid/civ085.
   PubMedGoogle Scholar
• Dowdell, P., S. Chankhamhaengdecha, W. Panbangred, T. Janvilisri, and A. Aroonnual. 2020. Probiotic activity of Enterococcus faecium and Lactococcus lactis isolated from Thai fermented sausages and their protective effect against Clostridium difficile. Probiotics and Antimicrobial Proteins 12 (2):641–648. doi: 10.1007/s12602-019-09536-7.
   PubMedGoogle Scholar
• Encarnacion, C. O., A. M. Loranger, A. Bharatkumar, and G. H. Almassi. 2016. Bacterial endocarditis caused by Lactobacillus acidophilus leading to rupture of sinus of Valsalva aneurysm. Texas Heart Institute Journal 43 (2):161–164. doi: 10.14503/THIJ-15-5121.
   PubMed Web of Science ®Google Scholar
• Enko, D., and G. Kriegshäuser. 2017. Functional 13C-urea and glucose hydrogen/methane breath tests reveal significant association of small intestinal bacterial overgrowth in individuals with active Helicobacter pylori infection. Clinical Biochemistry 50 (1–2):46–49. doi: 10.1016/j.clinbiochem.2016.08.017.
   PubMed Web of Science ®Google Scholar
• Fanning, S., L. J. Hall, M. Cronin, A. Zomer, J. MacSharry, D. Goulding, M. O'Connell Motherway, F. Shanahan, K. Nally, G. Dougan, et al. 2012. Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection. Proceedings of the National Academy of Sciences 109 (6):2108–2113. doi: 10.1073/pnas.1115621109.
   PubMed Web of Science ®Google Scholar
• Fijan, S. 2014. Microorganisms with claimed probiotic properties: An overview of recent literature. International Journal of Environmental Research and Public Health 11 (5):4745–4767. doi: 10.3390/ijerph110504745.
   PubMed Web of Science ®Google Scholar
• Foley, A., R. Burgell, J. S. Barrett, and P. R. Gibson. 2014. Management strategies for abdominal bloating and distension. Gastroenterology & Hepatology 10 (9):561–571.
   Google Scholar
• Foo, H. L., T. C. Loh, N. E. A. Mutalib, and R. A. Rahim. 2019. Chapter 21 the Myth and therapeutic potentials of postbiotics. In Microbiome and metabolome in diagnosis, therapy, and other strategic applications, ed. J. Faintuch and S. Faintuch, 201–211. Cambridge: Academic Press. doi: 10.1016/b978-0-12-815249-2.00021-x.
   Google Scholar
• Francescone, R., V. Hou, and S. I. Grivennikov. 2014. Microbiome, inflammation and cancer. The Cancer Journal 20 (3):181–189. doi: 10.1097/PPO.0000000000000048.
   PubMed Web of Science ®Google Scholar
• Franko, B., M. Vaillant, C. Recule, E. Vautrin, J. Brion, and P. Pavese. 2013. Lactobacillus paracasei endocarditis in a consumer of probiotics. Médecine et Maladies Infectieuses 43 (4):171–173. doi: 10.1016/j.medmal.2013.01.007.
   PubMed Web of Science ®Google Scholar
• Freitas, F., V. D. Alves, and M. A. Reis. 2011. Advances in bacterial exopolysaccharides: From production to biotechnological applications. Trends in Biotechnology 29 (8):388–398. doi: 10.1016/j.tibtech.2011.03.008.
   PubMed Web of Science ®Google Scholar
• Fujiki, T., Y. Hirose, Y. Yamamoto, and S. Murosaki. 2012. Enhanced immunomodulatory activity and stability in simulated digestive juices of Lactobacillus plantarum L-137 by heat treatment. Bioscience, Biotechnology, and Biochemistry 76 (5):918–922. doi: 10.1271/bbb.110919.
   PubMed Web of Science ®Google Scholar
• Galimberti, A., A. Bruno, V. Mezzasalma, F. De Mattia, I. Bruni, and M. Labra. 2015. Emerging DNA-based technologies to characterize food ecosystems. Food Research International 69:424–433. doi: 10.1016/j.foodres.2015.01.017.
   Web of Science ®Google Scholar
• Gao, J., Y. Li, Y. Wan, T. Hu, L. Liu, S. Yang, Z. Gong, Q. Zeng, Y. Wei, W. Yang, et al. 2019. A novel postbiotic from Lactobacillus rhamnosus GG with a beneficial effect on intestinal barrier function. Frontiers in Microbiology 10:477. doi: 10.3389/fmicb.2019.00477.
   PubMed Web of Science ®Google Scholar
• Gareau, M. G., P. M. Sherman, and W. A. Walker. 2010. Probiotics and the gut microbiota in intestinal health and disease. Nature Reviews Gastroenterology & Hepatology 7 (9):503–514. doi: 10.1038/nrgastro.2010.117.
   PubMed Web of Science ®Google Scholar
• Generoso, S. V., M. L. Viana, R. G. Santos, R. M. Arantes, F. S. Martins, J. R. Nicoli, J. A. Machado, M. I. T. Correia, and V. N. Cardoso. 2011. Protection against increased intestinal permeability and bacterial translocation induced by intestinal obstruction in mice treated with viable and heat-killed Saccharomyces boulardii. European Journal of Nutrition 50 (4):261–269. doi: 10.1007/s00394-010-0134-7.
   PubMed Web of Science ®Google Scholar
• Gezginc, Y., I. Akyol, E. Kuley, and F. Özogul. 2013. Biogenic amines formation in Streptococcus thermophilus isolated from home-made natural yogurt. Food Chemistry 138 (1):655–662. doi: 10.1016/j.foodchem.2012.10.138.
   PubMed Web of Science ®Google Scholar
• Gill, H., and K. Rutherfurd. 2001. Viability and dose–response studies on the effects of the immunoenhancing lactic acid bacterium Lactobacillus rhamnosus in mice. British Journal of Nutrition 86 (2):285–289. doi: 10.1079/BJN2001402.
   PubMed Web of Science ®Google Scholar
• Graspeuntner, S., S. Waschina, S. Künzel, N. Twisselmann, T. K. Rausch, K. Cloppenborg-Schmidt, J. Zimmermann, D. Viemann, E. Herting, W. Göpel, et al. 2019. Gut dysbiosis with Bacilli dominance and accumulation of fermentation products precedes late-onset sepsis in preterm infants. Clinical Infectious Diseases 69 (2):268–277. doi: 10.1093/cid/ciy882.
   PubMed Web of Science ®Google Scholar
• Guéniche, A., P. Bastien, J. M. Ovigne, M. Kermici, G. Courchay, V. Chevalier, L. Breton, and I. Castiel‐Higounenc. 2009. Bifidobacterium longum lysate, a new ingredient for reactive skin. Experimental Dermatology 19 (8):e1–e8. doi: 10.1111/j.1600-0625.2009.00932.x.
   Web of Science ®Google Scholar
• Haghshenas, B., M. Haghshenas, Y. Nami, A. Y. Khosroushahi, N. Abdullah, A. Barzegari, R. Rosli, and M. S. Hejazi. 2016. Probiotic assessment of Lactobacillus plantarum 15HN and Enterococcus mundtii 50H isolated from traditional dairies microbiota. Advanced Pharmaceutical Bulletin 6 (1):37–47. doi: 10.15171/apb.2016.007.
   PubMedGoogle Scholar
• Hamer, H. M., D. Jonkers, K. Venema, S. Vanhoutvin, F. Troost, and R. J. Brummer. 2008. Review article: The role of butyrate on colonic function. Alimentary Pharmacology & Therapeutics 27 (2):104–119. doi: 10.1111/j.1365-2036.2007.03562.x.
   PubMed Web of Science ®Google Scholar
• Hasan, A., B. A. Paray, A. Hussain, F. A. Qadir, F. Attar, F. M. Aziz, M. Sharifi, H. Derakhshankhah, B. Rasti, M. Mehrabi, et al. 2020. A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin. Journal of Biomolecular Structure & Dynamics. 1–9. doi: 10.1080/07391102.2020.1754293. PMC: 32274964.
   Web of Science ®Google Scholar
• Hoang, T. K., B. He, T. Wang, D. Q. Tran, J. M. Rhoads, and Y. Liu. 2018. Protective effect of Lactobacillus reuteri DSM 17938 against experimental necrotizing enterocolitis is mediated by Toll-like receptor 2. American Journal of Physiology. Gastrointestinal and Liver Physiology 315 (2):G231–G240. doi: 10.1152/ajpgi.00084.2017.
   PubMed Web of Science ®Google Scholar
• Hodzic, Z., A. M. Bolock, and M. Good. 2017. The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis. Frontiers in Pediatrics 5:40. doi: 10.3389/fped.2017.00040.
   PubMed Web of Science ®Google Scholar
• Homayouni-Rad, A., L. Aghebati Maleki, H. Samadi Kafil, and A. Abbasi. 2021. Postbiotics: A novel strategy in food allergy treatment. Critical Reviews in Food Science and Nutrition 61 (3):492–499. doi: 10.1080/10408398.2020.1738333.
   PubMed Web of Science ®Google Scholar
• Homayouni-Rad, A., H. Fathi-Zavoshti, N. Douroud, N. Shahbazi, and A. Abbasi. 2020. Evaluating the Role of Postbiotics as a New Generation of Probiotics in Health and Diseases. Journal of Ardabil University of Medical Sciences 19 (4):381–399. doi: 10.29252/jarums.19.4.381.
   Google Scholar
• Homayouni-Rad, A., H. Samadi Kafil, H. Fathi Zavoshti, N. Shahbazi, and A. Abbasi. 2020. Therapeutically Effects of Functional Postbiotic Foods. Clinical Excellence 10 (2):33–52.
   Google Scholar
• Hosseinian, S.-A., A. Haddad-Mashadrizeh, and S. Dolatabadi. 2018. Simulation and Stability Assessment of Anti-EpCAM Immunotoxin for Cancer Therapy. Advanced Pharmaceutical Bulletin 8 (3):447–455. doi: 10.15171/apb.2018.052.
   PubMed Web of Science ®Google Scholar
• Hou, Q., L. Ye, H. Liu, L. Huang, Q. Yang, J. Turner, and Q. Yu. 2018. Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22. Cell Death and Differentiation 25 (9):1657–1670. doi: 10.1038/s41418-018-0070-2.
   PubMed Web of Science ®Google Scholar
• Hsiao, W. W. L., C. Metz, D. P. Singh, and J. Roth. 2008. The microbes of the intestine: An introduction to their metabolic and signaling capabilities. Endocrinology and Metabolism Clinics of North America 37 (4):857–871. doi: 10.1016/j.ecl.2008.08.006.
   PubMed Web of Science ®Google Scholar
• Hynönen, U., and A. Palva. 2013. Lactobacillus surface layer proteins: Structure, function and applications. Applied Microbiology and Biotechnology 97 (12):5225–5243. doi: 10.1007/s00253-013-4962-2.
   PubMed Web of Science ®Google Scholar
• Iovino, P., C. Bucci, F. Tremolaterra, A. Santonicola, and G. Chiarioni. 2014. Bloating and functional gastro-intestinal disorders: Where are we and where are we going? World Journal of Gastroenterology 20 (39):14407–14419. doi: 10.3748/wjg.v20.i39.14407.
   PubMed Web of Science ®Google Scholar
• Ishikawa, H., E. Kutsukake, T. Fukui, I. Sato, T. Shirai, T. Kurihara, N. Okada, H. Danbara, M. Toba, N. Kohda, et al. 2010. Oral administration of heat-killed Lactobacillus plantarum strain b240 protected mice against Salmonella enterica Serovar Typhimurium. Bioscience, Biotechnology, and Biochemistry 74 (7):1338–1342. doi: 10.1271/bbb.90871.
   PubMed Web of Science ®Google Scholar
• Ismail, B. 2017. The use of probiotics as vaccine vectors to prevent viral infections. In New insights on antiviral probiotics, 47–60. Cham: Springer International Publishing. doi: 10.1007/978-3-319-49688-7-2.
   Google Scholar
• Jafari, B., R. A. K. Nejad, F. Vaziri, and S. D. Siadat. 2019. Evaluation of the effects of extracellular vesicles derived from Faecalibacterium prausnitzii on lung cancer cell line. Biologia 74 (7):889–898. doi: 10.2478/s11756-019-00229-8.
   Web of Science ®Google Scholar
• Jamalkandi, S. A., A. Ahmadi, I. Ahrari, J. Salimian, M. Karimi, andM. Ghanei. 2020. Oral and nasal probiotic administration for the prevention and alleviation of allergic diseases, asthma and chronic obstructive pulmonary disease. Nutrition Research Reviews. 1–16. doi: 10.1017/S0954422420000116. PMC: 32281536.
   PubMed Web of Science ®Google Scholar
• Jensen, G. S., K. F. Benson, S. G. Carter, and J. R. Endres. 2010. GanedenBC30™ cell wall and metabolites: Anti-inflammatory and immune modulating effects in vitro. BMC Immunology 11 (1):15. doi: 10.1186/1471-2172-11-15.
   PubMedGoogle Scholar
• Jiang, X., G. Locke, R. Choung, A. Zinsmeister, C. Schleck, and N. J. Talley. 2008. Prevalence and risk factors for abdominal bloating and visible distention: A population-based study. Gut 57 (6):756–763. doi: 10.1136/gut.2007.142810.
   PubMed Web of Science ®Google Scholar
• Johnson‐Henry, K. C., K. E. Hagen, M. Gordonpour, T. A. Tompkins, and P. M. Sherman. 2007. Surface-layer protein extracts from Lactobacillus helveticus inhibit enterohaemorrhagic Escherichia coli O157:H7 adhesion to epithelial cells . Cellular Microbiology 9 (2):356–367. doi: 10.1111/j.1462-5822.2006.00791.x.
   PubMed Web of Science ®Google Scholar
• Joint, F. A. O. 2002. WHO working group report on drafting guidelines for the evaluation of probiotics in food. London, 30.
   Google Scholar
• Juturu, V., and J. C. Wu. 2018. Microbial production of bacteriocins: Latest research development and applications. Biotechnology Advances 36 (8):2187–2200. doi: 10.1016/j.biotechadv.2018.10.007.
   PubMed Web of Science ®Google Scholar
• Kaila, M., E. Isolauri, M. Saxelin, H. Arvilommi, and T. Vesikari. 1995. Viable versus inactivated lactobacillus strain GG in acute rotavirus diarrhoea. Archives of Disease in Childhood 72 (1):51–53. doi: 10.1136/adc.72.1.51.
   PubMed Web of Science ®Google Scholar
• Kareem, K. Y., F. Hooi Ling, L. Teck Chwen, O. May Foong, and S. Anjas Asmara. 2014. Inhibitory activity of postbiotic produced by strains of Lactobacillus plantarum using reconstituted media supplemented with inulin. Gut Pathogens 6 (1):23. doi: 10.1186/1757-4749-6-23.
   PubMed Web of Science ®Google Scholar
• Karimi, N., V. Jabbari, A. Nazemi, K. Ganbarov, N. Karimi, A. Tanomand, S. Karimi, A. Abbasi, B. Yousefi, and E. Khodadadi. 2020. Thymol, cardamom and Lactobacillus plantarum nanoparticles as a functional candy with high protection against Streptococcus mutans and tooth decay. Microbial Pathogenesis 148:104481.
   PubMed Web of Science ®Google Scholar
• Kawase, M., F. He, K. Miyazawa, A. Kubota, K. Yoda, and M. Hiramatsu. 2012. Orally administered heat-killed Lactobacillus gasseri TMC0356 can upregulate cell-mediated immunity in senescence-accelerated mice. FEMS Microbiology Letters 326 (2):125–130. doi: 10.1111/j.1574-6968.2011.02440.x.
   PubMed Web of Science ®Google Scholar
• Khan, N., L. Mendonca, A. Dhariwal, G. Fontes, D. Menzies, J. Xia, M. Divangahi, and I. L. King. 2019. Intestinal dysbiosis compromises alveolar macrophage immunity to Mycobacterium tuberculosis. Mucosal Immunology 12 (3):772–783. doi: 10.1038/s41385-019-0147-3.
   PubMed Web of Science ®Google Scholar
• Khodaii, Z., S. M. H. Ghaderian, and M. M. Natanzi. 2017. Probiotic bacteria and their supernatants protect enterocyte cell lines from enteroinvasive Escherichia coli (EIEC) invasion. International Journal of Molecular and Cellular Medicine 6 (3):183–189. doi: 10.22088/acadpub.BUMS.6.3.183.
   PubMed Web of Science ®Google Scholar
• Kim, K. W., S.-S. Kang, S.-J. Woo, O.-J. Park, K. B. Ahn, K.-D. Song, H.-K. Lee, C.-H. Yun, and S. H. Han. 2017. Lipoteichoic acid of probiotic Lactobacillus plantarum attenuates poly I:C-Induced IL-8 Production in Porcine Intestinal Epithelial Cells . Frontiers in Microbiology 8:1827. doi: 10.3389/fmicb.2017.01827.
   PubMed Web of Science ®Google Scholar
• Kim, M. J., S. Ku, S. Y. Kim, H. H. Lee, H. Jin, S. Kang, R. Li, T. V. Johnston, M. S. Park, and G. E. Ji. 2018. Safety Evaluations of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI. International Journal of Molecular Sciences 19 (5):1422. doi: 10.3390/ijms19051422.
   PubMed Web of Science ®Google Scholar
• Kim, H. G., S. Y. Lee, N. R. Kim, H. Y. Lee, M. Y. Ko, B. J. Jung, C. M. Kim, J. M. Lee, J. H. Park, S. H. Han, et al. 2011. Lactobacillus plantarum lipoteichoic acid down-regulated Shigella flexneri peptidoglycan-induced inflammation. Molecular Immunology 48 (4):382–391. doi: 10.1016/j.molimm.2010.07.011.
   PubMed Web of Science ®Google Scholar
• Kolling, Y., S. Salva, J. Villena, and S. Alvarez. 2018. Are the immunomodulatory properties of Lactobacillus rhamnosus CRL1505 peptidoglycan common for all Lactobacilli during respiratory infection in malnourished mice? PloS One 13 (3):e0194034. doi: 10.1371/journal.pone.0194034.
   PubMed Web of Science ®Google Scholar
• Konishi, H., M. Fujiya, H. Tanaka, N. Ueno, K. Moriichi, J. Sasajima, K. Ikuta, H. Akutsu, H. Tanabe, and Y. Kohgo. 2016. Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis. Nature Communications 7 (1):1–12. doi: 10.1038/ncomms12365.
   Google Scholar
• Konrad, P., J. Chojnacki, A. Gąsiorowska, C. Rudnicki, A. Kaczka, and C. Chojnacki. 2018. Therapeutic efficacy of amoxicillin and rifaximin in patients with small intestinal bacterial overgrowth and Helicobacter pylori infection. Przeglad Gastroenterologiczny 13 (3):213.
   PubMed Web of Science ®Google Scholar
• Konstantinov, S. R., H. Smidt, W. M. de Vos, S. C. M. Bruijns, S. K. Singh, F. Valence, D. Molle, S. Lortal, E. Altermann, T. R. Klaenhammer, et al. 2008. S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions. Proceedings of the National Academy of Sciences of the United States of America 105 (49):19474–19479. doi: 10.1073/pnas.0810305105.
   PubMed Web of Science ®Google Scholar
• Kopp, M. 2008. Probiotika in der Prävention und Therapie von Atopien. Monatsschrift Kinderheilkunde 156 (11):1084–1092. doi: 10.1007/s00112-008-1832-6.
   Google Scholar
• Kuley, E., E. Balıkcı, İ. Özoğul, S. Gökdogan, and F. Özoğul. 2012. Stimulation of cadaverine production by foodborne pathogens in the presence of Lactobacillus, Lactococcus, and Streptococcus spp. Journal of Food Science 77 (12):M650–M658. doi: 10.1111/j.1750-3841.2012.02825.x.
   PubMed Web of Science ®Google Scholar
• Kulkarni, H. S., and C. C. Khoury. 2014. Sepsis associated with Lactobacillus bacteremia in a patient with ischemic colitis. Indian Journal of Critical Care Medicine: Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine 18 (9):606.
   PubMedGoogle Scholar
• Kumar, R., P. Bansal, J. Singh, and S. Dhanda. 2020. Purification, partial structural characterization and health benefits of exopolysaccharides from potential probiotic Pediococcus acidilactici NCDC 252. Process Biochemistry 99:79–86. doi: 10.1016/j.procbio.2020.08.028.
   Web of Science ®Google Scholar
• Kurata, N., N. Tokashiki, K. Fukushima, T. Misao, N. Hasuoka, K. Kitagawa, M. Mashimo, J. W. Regan, T. Murayama, and H. Fujino. 2019. Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells. European Journal of Pharmacology 853:308–315. doi: 10.1016/j.ejphar.2019.04.014.
   PubMed Web of Science ®Google Scholar
• Lai, H.-H., C.-H. Chiu, M.-S. Kong, C.-J. Chang, and C.-C. Chen. 2019. Probiotic Lactobacillus casei: Effective for Managing Childhood Diarrhea by Altering Gut Microbiota and Attenuating Fecal Inflammatory Markers. Nutrients 11 (5):1150. doi: 10.3390/nu11051150.
   PubMed Web of Science ®Google Scholar
• Lee, N. M. 2020. Epidermal growth factor as a reliable marker of necrotizing enterocolitis in preterm neonates. Clinical and Experimental Pediatrics 63 (2):1–2.
   PubMedGoogle Scholar
• Lee, I.-C., S. Tomita, M. Kleerebezem, and P. A. Bron. 2013. The quest for probiotic effector molecules-unraveling strain specificity at the molecular level. Pharmacological Research 69 (1):61–74. doi: 10.1016/j.phrs.2012.09.010.
   PubMed Web of Science ®Google Scholar
• Lee, M. J., Z. L. Zang, E. Y. Choi, H. K. Shin, and G. E. Ji. 2002. Cytoskeleton reorganization and cytokine production of macrophages by Bifidobacterial cells and cell-free extracts. Journal of Microbiology and Biotechnology 12:398–405.
   Web of Science ®Google Scholar
• Liévin-Le Moal, V., L. E. Sarrazin-Davila, and A. L. Servin. 2007. An experimental study and a randomized, double-blind, placebo-controlled clinical trial to evaluate the antisecretory activity of Lactobacillus acidophilus strain LB against nonrotavirus diarrhea. Pediatrics 120 (4):e795–e803. doi: 10.1542/peds.2006-2930.
   PubMed Web of Science ®Google Scholar
• Lim, H.-S., J.-E. Yeu, S.-P. Hong, and M.-S. Kang. 2018. Characterization of antibacterial cell-free supernatant from oral care probiotic Weissella cibaria. Molecules 23 (8):1984. doi: 10.3390/molecules23081984.
   Web of Science ®Google Scholar
• Linn, Y. H., K. K. Thu, and N. H. H. Win. 2019. Effect of probiotics for the prevention of acute radiation-induced diarrhoea among cervical cancer patients: A randomized double-blind placebo-controlled study. Probiotics and Antimicrobial Proteins 11 (2):638–647. doi: 10.1007/s12602-018-9408-9.
   PubMed Web of Science ®Google Scholar
• Liu, G., L. Ren, Z. Song, C. Wang, and B. Sun. 2015. Purification and characteristics of bifidocin A, a novel bacteriocin produced by Bifidobacterium animals BB04 from centenarians' intestine. Food Control. 50:889–895. doi: 10.1016/j.foodcont.2014.10.049.
   Web of Science ®Google Scholar
• Liu, Z., Z. Zhang, L. Qiu, F. Zhang, X. Xu, H. Wei, and X. Tao. 2017. Characterization and bioactivities of the exopolysaccharide from a probiotic strain of Lactobacillus plantarum WLPL04. Journal of Dairy Science 100 (9):6895–6905. doi: 10.3168/jds.2016-11944.
   PubMed Web of Science ®Google Scholar
• Loh, T., D. Choe, H. Foo, A. Sazili, and M. Bejo. 2014. Effects of feeding different postbiotic metabolite combinations produced by Lactobacillus plantarum strains on egg quality and production performance, faecal parameters and plasma cholesterol in laying hens. BMC Veterinary Research 10 (1):149. doi: 10.1186/1746-6148-10-149.
   PubMed Web of Science ®Google Scholar
• Lukic, J., V. Chen, I. Strahinic, J. Begovic, H. Lev‐Tov, S. C. Davis, M. Tomic‐Canic, and I. Pastar. 2017. Probiotics or pro-healers: The role of beneficial bacteria in tissue repair. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society 25 (6):912–922. doi: 10.1111/wrr.12607.
   PubMed Web of Science ®Google Scholar
• Maeda, N., R. Nakamura, Y. Hirose, S. Murosaki, Y. Yamamoto, T. Kase, and Y. Yoshikai. 2009. Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice. International Immunopharmacology 9 (9):1122–1125. doi: 10.1016/j.intimp.2009.04.015.
   PubMed Web of Science ®Google Scholar
• Maia, L. P., Y. L. D. A. S. Levi, R. L. do Prado, C. d S. Santinoni, and J. A. Marsicano. 2019. Effects of probiotic therapy on serum inflammatory markers: A systematic review and meta-analysis. Journal of Functional Foods 54:466–478. doi: 10.1016/j.jff.2019.01.051.
   Web of Science ®Google Scholar
• Malagón-Rojas, J. N., A. Mantziari, S. Salminen, and H. Szajewska. 2020. Postbiotics for preventing and treating common infectious diseases in children: A systematic review. Nutrients 12 (2):389. doi: 10.3390/nu12020389.
   PubMed Web of Science ®Google Scholar
• Manivasagan, P, and S.-K. Kim. 2014. Extracellular polysaccharides produced by marine bacteria. Advances in Food and Nutrition Research 72:79–94. doi: 10.1016/B978-0-12-800269-8.00005-1. PMC: 25081078.
   PubMedGoogle Scholar
• Martín, R., C. Chamignon, N. Mhedbi-Hajri, F. Chain, M. Derrien, U. Escribano-Vázquez, P. Garault, A. Cotillard, H. P. Pham, C. Chervaux, et al. 2019. The potential probiotic Lactobacillus rhamnosus CNCM I-3690 strain protects the intestinal barrier by stimulating both mucus production and cytoprotective response. Scientific Reports 9 (1):5398. doi: 10.1038/s41598-019-41738-5.
   PubMedGoogle Scholar
• Martinelli, M., D. Ummarino, F. P. Giugliano, E. Sciorio, C. Tortora, D. Bruzzese, D. De Giovanni, I. Rutigliano, S. Valenti, C. Romano, et al. 2017. Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA 122) in infantile colic: An open randomized controlled trial. Neurogastroenterology & Motility 29 (12):e13145. doi: 10.1111/nmo.13145.
   Web of Science ®Google Scholar
• Miyauchi, E., H. Morita, and S. Tanabe. 2009. Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo. Journal of Dairy Science 92 (6):2400–2408. doi: 10.3168/jds.2008-1698.
   PubMed Web of Science ®Google Scholar
• Miyazawa, K., F. He, M. Kawase, A. Kubota, K. Yoda, and M. Hiramatsu. 2011. Enhancement of immunoregulatory effects of Lactobacillus gasseri TMC0356 by heat treatment and culture medium. Letters in Applied Microbiology 53 (2):210–216. doi: 10.1111/j.1472-765X.2011.03093.x.
   PubMed Web of Science ®Google Scholar
• Moghaddas Kia, E., Z. Ghasempour, S. Ghanbari, R. Pirmohammadi, and A. Ehsani. 2018. Development of probiotic yogurt by incorporation of milk protein concentrate (MPC) and microencapsulated Lactobacillus paracasei in gellan-caseinate mixture. British Food Journal 120 (7):1516–1528. doi: 10.1108/BFJ-12-2017-0668.
   Web of Science ®Google Scholar
• Mohamadshahi, M., M. Veissi, F. Haidari, H. Shahbazian, G.-A. Kaydani, and F. Mohammadi. 2014. Effects of probiotic yogurt consumption on inflammatory biomarkers in patients with type 2 diabetes. BioImpacts: BI 4 (2):83.
   PubMedGoogle Scholar
• Moludi, J., M. Alizadeh, N. Lotfi Yagin, Y. Pasdar, S. M. Nachvak, H. Abdollahzad, and A. Sadeghpour Tabaei. 2018. New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota. Journal of Cardiovascular and Thoracic Research 10 (3):129–137. doi: 10.15171/jcvtr.2018.21.
   PubMed Web of Science ®Google Scholar
• Moradi, M., K. Mardani, and H. Tajik. 2019. Characterization and application of postbiotics of Lactobacillus spp. on Listeria monocytogenes in vitro and in food models. LWT 111:457–464. doi: 10.1016/j.lwt.2019.05.072.
   Web of Science ®Google Scholar
• Mosca, F., M. L. Gianni, and M. Rescigno. 2019. Can postbiotics represent a new strategy for NEC? In Probiotics and child gastrointestinal health: Advances in microbiology, infectious diseases and public health. Vol. 10, 37–45. Cham: Springer International Publishing. doi: 10.1007/5584_2018_314.
   Google Scholar
• Mujagic, Z., P. de Vos, M. V. Boekschoten, C. Govers, H.-J H. M. Pieters, N. J. W. de Wit, P. A. Bron, A. A. M. Masclee, and F. J. Troost. 2017. The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial. Scientific Reports 7 (1):40128. doi: 10.1038/srep40128.
   PubMedGoogle Scholar
• Muñoz-González, C., C. Cueva, M. Ángeles Pozo-Bayón, and M. Victoria Moreno-Arribas. 2015. Ability of human oral microbiota to produce wine odorant aglycones from odourless grape glycosidic aroma precursors. Food Chemistry 187:112–119. doi: 10.1016/j.foodchem.2015.04.068.
   PubMed Web of Science ®Google Scholar
• Nakamura, S., T. Kuda, C. An, T. Kanno, H. Takahashi, and B. Kimura. 2012. Inhibitory effects of Leuconostoc mesenteroides 1RM3 isolated from narezushi, a fermented fish with rice, on Listeria monocytogenes infection to Caco-2 cells and A/J mice. Anaerobe 18 (1):19–24. doi: 10.1016/j.anaerobe.2011.11.006.
   PubMed Web of Science ®Google Scholar
• Nowak, B., M. Śróttek, M. Ciszek-Lenda, A. Skałkowska, A. Gamian, S. Górska, and J. Marcinkiewicz. 2020. Exopolysaccharide from Lactobacillus rhamnosus KL37 inhibits T cell-dependent immune response in mice. Archivum Immunologiae et Therapiae Experimentalis 68 (3):1–11. doi: 10.1007/s00005-020-00581-7.
   PubMed Web of Science ®Google Scholar
• Ordóñez, J. L., A. M. Troncoso, M. D. C. García-Parrilla, and R. M. Callejón. 2016. Recent trends in the determination of biogenic amines in fermented beverages–A review. Analytica Chimica Acta 939:10–25. doi: 10.1016/j.aca.2016.07.045.
   PubMed Web of Science ®Google Scholar
• Österlund, P., T. Ruotsalainen, R. Korpela, M. Saxelin, A. Ollus, P. Valta, M. Kouri, I. Elomaa, and H. Joensuu. 2007. Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: A randomised study. British Journal of Cancer 97 (8):1028–1034. doi: 10.1038/sj.bjc.6603990.
   PubMed Web of Science ®Google Scholar
• Ou, J., F. Carbonero, E. G. Zoetendal, J. P. DeLany, M. Wang, K. Newton, H. R. Gaskins, and S. J. D. O'Keefe. 2013. Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans. The American Journal of Clinical Nutrition 98 (1):111–120. doi: 10.3945/ajcn.112.056689.
   PubMed Web of Science ®Google Scholar
• Ou, C. C., S. L. Lin, J. J. Tsai, and M. Y. Lin. 2011. Heat-killed lactic acid bacteria enhance immunomodulatory potential by skewing the immune response toward Th1 polarization . Journal of Food Science 76 (5):M260–M267. doi: 10.1111/j.1750-3841.2011.02161.x.
   PubMed Web of Science ®Google Scholar
• Papadimitriou, K., G. Zoumpopoulou, B. Foligné, V. Alexandraki, M. Kazou, B. Pot, and E. Tsakalidou. 2015. Discovering probiotic microorganisms: In vitro, in vivo, genetic and omics approaches. Frontiers in Microbiology 6:58. doi: 10.3389/fmicb.2015.00058.
   PubMed Web of Science ®Google Scholar
• Papillon, S. C., S. S. Short, and H. R. Ford. 2020. Necrotizing enterocolitis. In Pediatric surgery: General principles and newborn surgery, 963–971. Berlin: Springer International Publishing. doi: 10.1007/978-3-662-43588-5_70.
   Google Scholar
• Pararajasingam, A., and J. Uwagwu. 2017. Lactobacillus: The not so friendly bacteria. Case Reports 2017:bcr-2016.
   Google Scholar
• Parkin, J., and B. Cohen. 2001. An overview of the immune system. The Lancet 357 (9270):1777–1789. doi: 10.1016/S0140-6736(00)04904-7.
   PubMed Web of Science ®Google Scholar
• Patel, R. M., and M. A. Underwood. 2018. Probiotics and necrotizing enterocolitis. Seminars in Pediatric Surgery 27 (1): 39–46. doi: 10.1053/j.sempedsurg.2017.11.008.
   PubMed Web of Science ®Google Scholar
• Patten, D. A., S. Leivers, M. J. Chadha, M. Maqsood, P. N. Humphreys, A. P. Laws, and A. Collett. 2014. The structure and immunomodulatory activity on intestinal epithelial cells of the EPSs isolated from Lactobacillus helveticus sp. Rosyjski and Lactobacillus acidophilus sp. 5e2. Carbohydrate Research 384:119–127. doi: 10.1016/j.carres.2013.12.008.
   PubMed Web of Science ®Google Scholar
• Peng, M., Z. Tabashsum, M. Anderson, A. Truong, A. K. Houser, J. Padilla, A. Akmel, J. Bhatti, S. O. Rahaman, and D. Biswas. 2020. Effectiveness of probiotics, prebiotics, and prebiotic-like components in common functional foods . Comprehensive Reviews in Food Science and Food Safety 19 (4):1908–1933. doi: 10.1111/1541-4337.12565.
   PubMed Web of Science ®Google Scholar
• Piqué, N., M. Berlanga, and D. Miñana-Galbis. 2019. Health benefits of heat-killed (Tyndallized) probiotics: An overview. International Journal of Molecular Sciences 20 (10):2534. doi: 10.3390/ijms20102534.
   PubMed Web of Science ®Google Scholar
• Poli, A., G. Anzelmo, and B. Nicolaus. 2010. Bacterial exopolysaccharides from extreme marine habitats: Production, characterization and biological activities. Marine Drugs 8 (6):1779–1802. doi: 10.3390/md8061779.
   PubMed Web of Science ®Google Scholar
• Qi, S., Y. Cui, J. Liu, X. Luo, and H. Wang. 2020. Lactobacillus rhamnosus GG components, SLP, gDNA and CpG, exert protective effects on mouse macrophages upon lipopolysaccharide challenge. Letters in Applied Microbiology 70 (2):118–127. doi: 10.1111/lam.13255.
   PubMed Web of Science ®Google Scholar
• Rad, A., A. Abbasi, A. Javadi, H. Pourjafar, M. Javadi, and M. Khaleghi. 2020. Comparing the microbial quality of traditional and industrial yoghurts. Biointerface Research in Applied Chemistry 10 (4):6020–6025.
   Web of Science ®Google Scholar
• Rad, A., A. Abbasi, H. Kafil, and K. Ganbarov. 2020. Potential pharmaceutical and food applications of postbiotics: A review. Current Pharmaceutical Biotechnology 21 (15):1576–1587. doi: 10.2174/1389201021666200516154833.
   Web of Science ®Google Scholar
• Rad, A. H., L. Aghebati-Maleki, H. S. Kafil, and A. Abbasi. 2020. Molecular mechanisms of postbiotics in colorectal cancer prevention and treatment. Critical Reviews in Food Science and Nutrition 15:1–17. doi: 10.1080/10408398.2020.1765310.
   Web of Science ®Google Scholar
• Rad, A. H., L. A. Maleki, H. S. Kafil, H. F. Zavoshti, and A. Abbasi. 2020a. Postbiotics as novel health-promoting ingredients in functional foods. Health Promotion Perspectives 10 (1):3–4. doi: 10.15171/hpp.2020.02.
   PubMed Web of Science ®Google Scholar
• Rad, A. H., L. A. Maleki, H. S. Kafil, H. F. Zavoshti, and A. Abbasi. 2020b. Postbiotics as promising tools for cancer adjuvant therapy. Advanced Pharmaceutical Bulletin 11 (1):1–5. doi: 10.34172/apb.2021.007.
   Google Scholar
• Rahbar Saadat, Y., B. Pourghassem Gargari, A. Shahabi, Y. Nami, and A. Yari Khosroushahi. 2020. Prophylactic role of Lactobacillus Paracasei exopolysaccharides on colon cancer cells through apoptosis not ferroptosis. Pharmaceutical Sciences. doi: 10.34172/PS.2020.39. [Online ahead of print].
   Web of Science ®Google Scholar
• Rai, A. K., A. Pandey, and D. Sahoo. 2019. Biotechnological potential of yeasts in functional food industry. Trends in Food Science & Technology 83:129–137. doi: 10.1016/j.tifs.2018.11.016.
   Web of Science ®Google Scholar
• Rajoka, M. S. R., H. Zhao, H. M. Mehwish, N. Li, Y. Lu, Z. Lian, D. Shao, M. Jin, Q. Li, L. Zhao, et al. 2019. Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk. Food Research International 123:286–297. doi: 10.1016/j.foodres.2019.05.002.
   PubMed Web of Science ®Google Scholar
• Rossoni, R. D., M. dos Santos Velloso, P. P. de Barros, J. A. de Alvarenga, J. D. dos Santos, A. C. C. dos Santos Prado, F. de Camargo Ribeiro, A. L. Anbinder, and J. C. Junqueira. 2018. Inhibitory effect of probiotic Lactobacillus supernatants from the oral cavity on Streptococcus mutans biofilms. Microbial Pathogenesis 123:361–367. doi: 10.1016/j.micpath.2018.07.032.
   PubMed Web of Science ®Google Scholar
• Saadat, Y. R., A. Y. Khosroushahi, and B. P. Gargari. 2019. A comprehensive review of anticancer, immunomodulatory and health beneficial effects of the lactic acid bacteria exopolysaccharides. Carbohydrate Polymers 217:79–89.
   PubMed Web of Science ®Google Scholar
• Saber, A., B. Alipour, Z. Faghfoori, and A. Yari Khosroushahi. 2017. Cellular and molecular effects of yeast probiotics on cancer. Critical Reviews in Microbiology 43 (1):96–115. doi: 10.1080/1040841X.2016.1179622.
   PubMed Web of Science ®Google Scholar
• Sanders, M. E., L. M. A. Akkermans, D. Haller, C. Hammerman, J. Heimbach, G. Hörmannsperger, G. Huys, D. D. Levy, F. Lutgendorff, D. Mack, et al. 2010. Safety assessment of probiotics for human use. Gut Microbes 1 (3):164–185. doi: 10.4161/gmic.1.3.12127.
   PubMed Web of Science ®Google Scholar
• Sanders, M. E., F. Guarner, R. Guerrant, P. R. Holt, E. M. Quigley, R. B. Sartor, P. M. Sherman, and E. A. Mayer. 2013. An update on the use and investigation of probiotics in health and disease. Gut 62 (5):787–796. doi: 10.1136/gutjnl-2012-302504.
   PubMed Web of Science ®Google Scholar
• Sarkar, A., and S. Mandal. 2016. Bifidobacteria-Insight into clinical outcomes and mechanisms of its probiotic action. Microbiological Research 192:159–171. doi: 10.1016/j.micres.2016.07.001.
   PubMed Web of Science ®Google Scholar
• Schwartz, D. J., O. N. Rebeck, and G. Dantas. 2019. Complex interactions between the microbiome and cancer immune therapy. Critical Reviews in Clinical Laboratory Sciences 56 (8):567–585. doi: 10.1080/10408363.2019.1660303.
   PubMed Web of Science ®Google Scholar
• Schwendicke, F., K. Horb, S. Kneist, C. Dörfer, and S. Paris. 2014. Effects of heat-inactivated Bifidobacterium BB12 on cariogenicity of Streptococcus mutans in vitro. Archives of Oral Biology 59 (12):1384–1390. doi: 10.1016/j.archoralbio.2014.08.012.
   PubMed Web of Science ®Google Scholar
• Segawa, S., M. Fujiya, H. Konishi, N. Ueno, N. Kobayashi, T. Shigyo, and Y. Kohgo. 2011. Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway. PloS One 6 (8):e23278. doi: 10.1371/journal.pone.0023278.
   PubMed Web of Science ®Google Scholar
• Seo, A. Y., N. Kim, and D. H. Oh. 2013. Abdominal bloating: Pathophysiology and treatment. Journal of Neurogastroenterology and Motility 19 (4):433–453. doi: 10.5056/jnm.2013.19.4.433.
   PubMed Web of Science ®Google Scholar
• Sharma, M., D. Chandel, and G. Shukla. 2020. Antigenotoxicity and cytotoxic potentials of metabiotics extracted from isolated probiotic, Lactobacillus rhamnosus MD 14 on Caco-2 and HT-29 human colon cancer cells. Nutrition and Cancer 72 (1):110–119. doi: 10.1080/01635581.2019.1615514.
   PubMed Web of Science ®Google Scholar
• Sharma, M., and G. Shukla. 2016. Metabiotics: One step ahead of probiotics; an insight into mechanisms involved in anticancerous effect in colorectal cancer. Frontiers in Microbiology 7:1940. doi: 10.3389/fmicb.2016.01940.
   PubMed Web of Science ®Google Scholar
• Shenderov, B. A. 2013. Metabiotics: Novel idea or natural development of probiotic conception. Microbial Ecology in Health and Disease 24 (1):20399.
   PubMedGoogle Scholar
• Shigwedha, N., L. Sichel, L. Jia, and L. Zhang. 2014. Probiotical Cell Fragments (PCFs) as “Novel Nutraceutical Ingredients. Journal of Biosciences and Medicines 2 (3):43–55. doi: 10.4236/jbm.2014.23007.
   Google Scholar
• Siegel, R. L., K. D. Miller, and A. Jemal. 2020. Cancer statistics, 2020. CA: A Cancer Journal for Clinicians 70 (1):7–30. doi: 10.3322/caac.21590.
   PubMed Web of Science ®Google Scholar
• Sokol, H., B. Pigneur, L. Watterlot, O. Lakhdari, L. G. Bermúdez-Humarán, J. J. Gratadoux, S. Blugeon, C. Bridonneau, J. P. Furet, G. Corthier, et al. 2008. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proceedings of the National Academy of Sciences of the United States of America 105 (43):16731–16736. ]. https://f1000.com/1135879. doi: 10.1073/pnas.0804812105.
   PubMed Web of Science ®Google Scholar
• Sonnenburg, J. L., and F. Bäckhed. 2016. Diet-microbiota interactions as moderators of human metabolism. Nature 535 (7610):56–64. doi: 10.1038/nature18846.
   PubMed Web of Science ®Google Scholar
• Subramanian, S., S. Huq, T. Yatsunenko, R. Haque, M. Mahfuz, M. A. Alam, A. Benezra, J. DeStefano, M. F. Meier, B. D. Muegge, et al. 2014. Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature 510 (7505):417–421. doi: 10.1038/nature13421.
   PubMed Web of Science ®Google Scholar
• Sugahara, H., R. Yao, T. Odamaki, and J. Z. Xiao. 2017. Differences between live and heat-killed bifidobacteria in the regulation of immune function and the intestinal environment. Beneficial Microbes 8 (3):463–472. doi: 10.3920/BM2016.0158.
   PubMed Web of Science ®Google Scholar
• Sun, P., J. Wang, and Y. Jiang. 2010. Effects of Enterococcus faecium (SF68) on immune function in mice. Food Chemistry 123 (1):63–68. doi: 10.1016/j.foodchem.2010.03.128.
   Web of Science ®Google Scholar
• Sunmola, A. A., O. O. Ogbole, T. O. Faleye, A. Adetoye, J. A. Adeniji, and F. A. Ayeni. 2019. Antiviral potentials of Lactobacillus plantarum, Lactobacillus amylovorus, and Enterococcus hirae against selected Enterovirus. Folia Microbiologica 64 (2):257–264. doi: 10.1007/s12223-018-0648-6.
   PubMed Web of Science ®Google Scholar
• Suresh Kumar, A., K. Mody, and B. Jha. 2007. Bacterial exopolysaccharides–a perception. Journal of Basic Microbiology 47 (2):103–117. doi: 10.1002/jobm.200610203.
   PubMed Web of Science ®Google Scholar
• Sutherland, I. W. 1990. Biotechnology of microbial exopolysaccharides. Vol. 9. Cambridge: Cambridge University Press.
   Google Scholar
• Takeda, S., M. Takeshita, Y. Kikuchi, B. Dashnyam, S. Kawahara, H. Yoshida, W. Watanabe, M. Muguruma, and M. Kurokawa. 2011. Efficacy of oral administration of heat-killed probiotics from Mongolian dairy products against influenza infection in mice: Alleviation of influenza infection by its immunomodulatory activity through intestinal immunity. International Immunopharmacology 11 (12):1976–1983. doi: 10.1016/j.intimp.2011.08.007.
   PubMed Web of Science ®Google Scholar
• Tannock, G. W., J. B. Luchansky, L. Miller, H. Connell, S. Thode-Andersen, A. A. Mercer, and T. R. Klaenhammer. 1994. Molecular characterization of a plasmid-borne (pGT633) erythromycin resistance determinant (ermGT) from Lactobacillus reuteri 100-63. Plasmid 31 (1):60–71. doi: 10.1006/plas.1994.1007.
   PubMed Web of Science ®Google Scholar
• Tarrerias, A. L., V. Costil, F. Vicari, J. C. Létard, P. Adenis-Lamarre, A. Aisène, D. Batistelli, G. Bonnaud, S. Carpentier, P. Dalbiès, et al. 2011. The effect of inactivated Lactobacillus LB fermented culture medium on symptom severity: observational investigation in 297 patients with diarrhea-predominant irritable bowel syndrome. Digestive Diseases 29 (6):588–591. doi: 10.1159/000332987.
   PubMed Web of Science ®Google Scholar
• Taverniti, V., and S. Guglielmetti. 2011. The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: Proposal of paraprobiotic concept). Genes & Nutrition 6 (3):261–274. doi: 10.1007/s12263-011-0218-x.
   PubMed Web of Science ®Google Scholar
• Taylor, A. L., J. A. Dunstan, and S. L. Prescott. 2007. Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: A randomized controlled trial. Journal of Allergy and Clinical Immunology 119 (1):184–191. doi: 10.1016/j.jaci.2006.08.036.
   PubMed Web of Science ®Google Scholar
• Tejada-Simon, M. V., and J. J. Pestka. 1999. Proinflammatory cytokine and nitric oxide induction in murine macrophages by cell wall and cytoplasmic extracts of lactic acid bacteria. Journal of Food Protection 62 (12):1435–1444. doi: 10.4315/0362-028x-62.12.1435.
   PubMed Web of Science ®Google Scholar
• Tiptiri-Kourpeti, A., K. Spyridopoulou, V. Santarmaki, G. Aindelis, E. Tompoulidou, E. E. Lamprianidou, G. Saxami, P. Ypsilantis, E. S. Lampri, C. Simopoulos, et al. 2016. Lactobacillus casei exerts anti-proliferative effects accompanied by apoptotic cell death and up-regulation of TRAIL in colon carcinoma cells. PloS One 11 (2):e0147960. doi: 10.1371/journal.pone.0147960.
   PubMed Web of Science ®Google Scholar
• Tomasik, P., and P. Tomasik. 2020. Probiotics, non-dairy prebiotics and postbiotics in nutrition. Applied Sciences 10 (4):1470. doi: 10.3390/app10041470.
   Google Scholar
• Underwood, M. A. 2019. Probiotics and the prevention of necrotizing enterocolitis. Journal of Pediatric Surgery 54 (3):405–412. doi: 10.1016/j.jpedsurg.2018.08.055.
   PubMed Web of Science ®Google Scholar
• Vaghef-Mehrabany, E., L. Vaghef-Mehrabany, M. Asghari-Jafarabadi, A. Homayouni-Rad, K. Issazadeh, and B. Alipour. 2017. Effects of probiotic supplementation on lipid profile of women with rheumatoid arthritis: A randomized placebo-controlled clinical trial. Health Promotion Perspectives 7 (2):95–101. doi: 10.15171/hpp.2017.17.
   PubMed Web of Science ®Google Scholar
• Vahabnezhad, E., A. B. Mochon, L. J. Wozniak, and D. A. Ziring. 2013. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. Journal of Clinical Gastroenterology 47 (5):437–439. doi: 10.1097/MCG.0b013e318279abf0.
   PubMed Web of Science ®Google Scholar
• Vandenplas, Y., A. Bacarea, M. Marusteri, V. Bacarea, M. Constantin, and M. Manolache. 2017. Efficacy and safety of APT198K for the treatment of infantile colic: A pilot study. Journal of Comparative Effectiveness Research 6 (2):137–144. doi: 10.2217/cer-2016-0059.
   PubMed Web of Science ®Google Scholar
• Vanichanan, J., V. Chávez, A. Wanger, A. M. De Golovine, and K. J. Vigil. 2016. Carbapenem-resistant Lactobacillus intra-abdominal infection in a renal transplant recipient with a history of probiotic consumption. Infection 44 (6):793–796. doi: 10.1007/s15010-016-0903-1.
   PubMed Web of Science ®Google Scholar
• Venegas, D. P., K. Marjorie, G. Landskron, M. J. González, R. Quera, G. Dijkstra, H. J. Harmsen, K. N. Faber, and M. A. Hermoso. 2019. Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Frontiers in Immunology 10:277. doi: 10.3389/fimmu.2019.00277.
   PubMed Web of Science ®Google Scholar
• Vidal, K., A. Donnet-Hughes, and D. Granato. 2002. Lipoteichoic acids from Lactobacillus johnsonii strain La1 and Lactobacillus acidophilus strain La10 antagonize the responsiveness of human intestinal epithelial HT29 cells to lipopolysaccharide and gram-negative bacteria. Infection and Immunity 70 (4):2057–2064. doi: 10.1128/IAI.70.4.2057-2064.2002.
   PubMed Web of Science ®Google Scholar
• Vinogradov, E., I. Sadovskaya, T. Grard, and M.-P. Chapot-Chartier. 2016. Structural studies of the rhamnose-rich cell wall polysaccharide of Lactobacillus casei BL23. Carbohydrate Research 435:156–161. doi: 10.1016/j.carres.2016.10.002.
   PubMed Web of Science ®Google Scholar
• Wang, C., J. Chuprom, Y. Wang, and L. Fu. 2020. Beneficial bacteria for aquaculture: Nutrition, bacteriostasis and immunoregulation. Journal of Applied Microbiology 128 (1):28–40. doi: 10.1111/jam.14383.
   PubMed Web of Science ®Google Scholar
• Wang, K., W. Li, X. Rui, X. Chen, M. Jiang, and M. Dong. 2014. Characterization of a novel exopolysaccharide with antitumor activity from Lactobacillus plantarum 70810. International Journal of Biological Macromolecules 63:133–139. doi: 10.1016/j.ijbiomac.2013.10.036.
   PubMed Web of Science ®Google Scholar
• Wasilewska, E., D. Zlotkowska, and B. Wroblewska. 2019. Yogurt starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus ameliorate symptoms and modulate the immune response in a mouse model of dextran sulfate sodium-induced colitis. Journal of Dairy Science 102 (1):37–53. doi: 10.3168/jds.2018-14520.
   PubMed Web of Science ®Google Scholar
• Weber, E., Q. Reynaud, F. Suy, A. Gagneux-Brunon, A. Carricajo, A. Guillot, and E. Botelho-Nevers. 2015. Bifidobacterium species bacteremia: Risk factors in adults and infants. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America 61 (3):482–484. doi: 10.1093/cid/civ347.
   PubMed Web of Science ®Google Scholar
• Whitfield, G. B., L. S. Marmont, and P. L. Howell. 2015. Enzymatic modifications of exopolysaccharides enhance bacterial persistence. Frontiers in Microbiology 6:471. doi: 10.3389/fmicb.2015.00471.
   PubMed Web of Science ®Google Scholar
• Wu, Z., D. Pan, Y. Guo, Y. Sun, and X. Zeng. 2015. Peptidoglycan diversity and anti-inflammatory capacity in Lactobacillus strains. Carbohydrate Polymers 128:130–137. doi: 10.1016/j.carbpol.2015.04.026.
   PubMed Web of Science ®Google Scholar
• Wu, M.-H., T.-M. Pan, Y.-J. Wu, S.-J. Chang, M.-S. Chang, and C.-Y. Hu. 2010. Exopolysaccharide activities from probiotic bifidobacterium: Immunomodulatory effects (on J774A.1 macrophages) and antimicrobial properties. Int J Food Microbiol 144 (1):104–110. doi: 10.1016/j.ijfoodmicro.2010.09.003.
   PubMed Web of Science ®Google Scholar
• Xiao, S.-D., Z. De Zhang, H. Lu, S. H. Jiang, H. Y. Liu, G. S. Wang, G. M. Xu, Z. B. Zhang, G. J. Lin, and G. L. Wang. 2003. Multicenter, randomized, controlled trial of heat-killedLactobacillus acidophilus LB in patients with chronic diarrhea. Advances in Therapy 20 (5):253–260. doi: 10.1007/BF02849854.
   PubMed Web of Science ®Google Scholar
• Xiao, X., J. Kim, Q. Sun, D. Kim, C.-S. Park, T.-S. Lu, and Y. Park. 2015. Preventive effects of cranberry products on experimental colitis induced by dextran sulphate sodium in mice. Food Chemistry 167:438–446. doi: 10.1016/j.foodchem.2014.07.006.
   PubMed Web of Science ®Google Scholar
• Xiao, S. D., D. Z. Zhang, H. Lu, S. H. Jiang, H. Y. Liu, G. S. Wang, G. M. Xu, Z. B. Zhang, G. J. Lin, and G. L. Wang. 2002. Multicenter randomized controlled trial of heat‐killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Chinese Journal of Digestive Diseases 3 (4):167–171. doi: 10.1046/j.1443-9573.2002.00095.x.
   Google Scholar
• Yan, F., H. Cao, T. L. Cover, R. Whitehead, M. K. Washington, and D. B. Polk. 2007. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 132 (2):562–575. doi: 10.1053/j.gastro.2006.11.022.
   PubMed Web of Science ®Google Scholar
• Yan, F., and D. B. Polk. 2010. Disruption of NF-κB signalling by ancient microbial molecules: Novel therapies of the future? Gut 59 (4):421–426. doi: 10.1136/gut.2009.179614.
   Google Scholar
• Yu, B., Z. Wang, L. Almutairi, S. Huang, and M.-H. Kim. 2020. Harnessing iron-oxide nanoparticles towards the improved bactericidal activity of macrophage against Staphylococcus aureus. Nanomedicine: Nanotechnology, Biology and Medicine 24:102158. doi: 10.1016/j.nano.2020.102158.
   PubMed Web of Science ®Google Scholar
• Zeng, J., J. Jiang, W. Zhu, and Y. Chu. 2016. Heat-killed yogurt-containing lactic acid bacteria prevent cytokine-induced barrier disruption in human intestinal Caco-2 cells. Annals of Microbiology 66 (1):171–178. doi: 10.1007/s13213-015-1093-2.
   Web of Science ®Google Scholar
• Zhang, Z., R. Cai, W. Zhang, Y. Fu, and N. Jiao. 2017. A novel exopolysaccharide with metal adsorption capacity produced by a marine bacterium Alteromonas sp. Marine Drugs 15 (6):175. doi: 10.3390/md15060175.
   Web of Science ®Google Scholar
• Zheng, B., J. van Bergenhenegouwen, S. Overbeek, H. J. van de Kant, J. Garssen, G. Folkerts, P. Vos, M. E. Morgan, and A. D. Kraneveld. 2014. Bifidobacterium breve attenuates murine dextran sodium sulfate-induced colitis and increases regulatory T cell responses. PloS One 9 (5):e95441. doi: 10.1371/journal.pone.0095441.
   PubMed Web of Science ®Google Scholar
• Zheng, M., R. Zhang, X. Tian, X. Zhou, X. Pan, and A. Wong. 2017. Assessing the risk of probiotic dietary supplements in the context of antibiotic resistance. Frontiers in Microbiology 8:908. doi: 10.3389/fmicb.2017.00908.
   PubMed Web of Science ®Google Scholar